Calculating statistical power in Mendelian randomization studies.
paper
Cited
Public
Unavailable
- Authors
- Brion, Marie-Jo A; Shakhbazov, Konstantin; Visscher, Peter M
- Year
- 2013
- Journal
- International journal of epidemiology
- PMID
- 24159078
- DOI
- 10.1093/ije/dyt179
- PMCID
- PMC3807619
In Mendelian randomization (MR) studies, where genetic variants are used as proxy measures for an exposure trait of interest, obtaining adequate statistical power is frequently a concern due to the small amount of variation in a phenotypic trait that is typically explained by genetic variants. A range of power estimates based on simulations and specific parameters for two-stage least squares (2SLS) MR analyses based on continuous variables has previously been published. However there are presently no specific equations or software tools one can implement for calculating power of a given MR study. Using asymptotic theory, we show that in the case of continuous variables and a single instrument, for example a single-nucleotide polymorphism (SNP) or multiple SNP predictor, statistical power for a fixed sample size is a function of two parameters: the proportion of variation in the exposure variable explained by the genetic predictor and the true causal association between the exposure and outcome variable. We demonstrate that power for 2SLS MR can be derived using the non-centrality parameter (NCP) of the statistical test that is employed to test whether the 2SLS regression coefficient is zero. We show that the previously published power estimates from simulations can be represented theoretically using this NCP-based approach, with similar estimates observed when the simulation-based estimates are compared with our NCP-based approach. General equations for calculating statistical power for 2SLS MR using the NCP are provided in this note, and we implement the calculations in a web-based application.
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| Multi-omics insights of immune cells in the risk and prognosis of idiopathic membranous nephropathy. | Song X et al. | β | 2025 | β |
| Multiple thyroid disorders and risk of osteoporosis: a two-sample Mendelian randomization study. | Shi G et al. | β | 2025 | β |
| Narcolepsy as a potential risk factor for Schizophrenia. | Eghtedarian R et al. | β | 2025 | β |
| Neuroticism and asthma: Mendelian randomization analysis reveals causal link with mood swings and BMI mediation. | Wu DC et al. | β | 2025 | β |
| No Genetic Causal Relationship Between HIV Infection and Insulin Resistance, Diabetes: A Bidirectional Mendelian Randomization Analysis. | Liu P et al. | β | 2025 | β |
| No significant association between anesthetics administered during delivery and autism spectrum disorder: a Mendelian randomization study. | Zhou W et al. | β | 2025 | β |
| Nutritional interventions for preventing cognitive decline in patients with mild cognitive impairment and Alzheimer's disease: A comprehensive network meta-analysis and Mendelian Randomization study. | He Q et al. | β | 2025 | β |
| Observational and Genetic Evidence Reveals the Effect of Serum Lipid Levels on COPD Risk. | Jia G et al. | β | 2025 | β |
| Omega-3 Fatty Acids as Protective Factors for Age-Related Macular Degeneration: Prospective Cohort and Mendelian Randomization Analyses. | Xue CC et al. | β | 2025 | β |
| One-carbon metabolism and risk of PCOS: insights from Mendelian randomization. | Zhao Y et al. | β | 2025 | β |
| Perturbation of Circulating Inflammatory Proteins Mediates the Relationship Between Cholecystectomy and Nonalcoholic Fatty Liver Disease: A Multivariate and Mediation Mendelian Randomization Study. | Chen C et al. | β | 2025 | β |
| Plasma tissue factor as a promising marker in multiple sclerosis: Evidence from a two-sample Mendelian randomization study. | Pan R et al. | β | 2025 | β |
| Polygenic overlap between subjective well-being and psychiatric disorders and cross-ancestry validation. | Jung JY et al. | β | 2025 | β |
| Preeclampsia, gestational hypertension, and cardiovascular disease risk: a genetic epidemiological study. | Taageby Nielsen S et al. | β | 2025 | β |
| Protective Effect of Ethoxyquin and N-acetylcysteine on Biochemical and Pathological Changes Induced by Chronic Exposure to Aflatoxins in Laying Hens. | de-Luna-LΓ³pez MC et al. | β | 2025 | β |
| Proteome-wide Mendelian randomization and colocalization analysis identify CD5 as a plasma protein associated with cerebral palsy. | Bai C et al. | β | 2025 | β |
| Proteome-wide mendelian randomization reveals circulating proteins causally associated with childhood body mass index. | Avocegamou R et al. | β | 2025 | β |
| Psychological, social factors, and smoking behavior mediated the effects of cannabis use on personality disorders: A Mendelian randomization study. | Ni Y et al. | β | 2025 | β |
| PsyRiskMR: A Comprehensive Resource for Identifying Psychiatric Disorder Risk Factors Through Mendelian Randomization. | Li X et al. | β | 2025 | β |
| Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study. | Morales Berstein F et al. | β | 2025 | β |
| Relationships among immune cells, metabolites, and non-small cell lung cancer: a mediation Mendelian randomization study. | Chen Y et al. | β | 2025 | β |
| Reply to: "Reassessing the causal association between frailty and chronic liver disease: Evidence from genetic analyses". | Zhong Q et al. | β | 2025 | β |
| Revisiting the causal impact of lipid traits on metabolic dysfunction-associated fatty liver disease: Insights from a multidimensional plasma lipid profile. | Xie F et al. | β | 2025 | β |
| Rheumatoid Arthritis, Circulating Inflammatory Proteins, and Hypertension: A Mendelian Randomization Study. | Jia G et al. | β | 2025 | β |
| Serum Urate and Atrial Fibrillation: A Bidirectional Mendelian Randomization Study. | Yu S et al. | β | 2025 | β |
| Smoking, alcohol and risk of sarcopenia: a Mendelian randomisation study. | Sha T et al. | β | 2025 | β |
| Snoring as a Possible Protective Factor for Temporomandibular Joint Disorders. | Wu Y et al. | β | 2025 | β |
| Specific plasma lipid species in children are causally associated with kawasaki disease: a mendelian randomization analysis. | Zhen C et al. | β | 2025 | β |
| Sphingolipid metabolism-related genes for the diagnosis of metabolic syndrome by integrated bioinformatics analysis and Mendelian randomization identification. | Li W et al. | β | 2025 | β |
| Strengthening the reporting of observational studies in epidemiology using Mendelian randomization (STROBE-MR): a Korean translation of explanation and elaboration. | Skrivankova VW et al. | β | 2025 | β |
| Systematic genetic investigation on relative macronutrient intake, circulating metabolic biomarkers and the risk of autoimmune diseases. | Zheng S et al. | β | 2025 | β |
| The association between basal metabolic rate and ischemic stroke: a Mendelian randomization study. | Chen Y et al. | β | 2025 | β |
| The causal association between liver diseases and vascular dementia: A two-sample Mendelian randomization study. | Zhang X et al. | β | 2025 | β |
| The causal relationship between body mass index and perianal abscess: a Mendelian randomization study. | Wu L et al. | β | 2025 | β |
| The causal relationships between gut microbiota and venous thromboembolism: a Mendelian randomization study. | Huang P et al. | β | 2025 | β |
| The causal role of male pubertal timing for the development of externalizing and internalizing traits: results from Mendelian randomization studies. | Dinkelbach L et al. | β | 2025 | β |
| The "double-edged sword" effect of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of endometriosis (EMS). | Shi Z et al. | β | 2025 | β |
| The Effects of Specific Gut Microbiota on Hyperuricemia - A Mendelian Randomization Analysis and Clinical Validation. | Aikepa D et al. | β | 2025 | β |
| The impact of cannabis use on erectile dysfunction and sex hormones: a Mendelian randomization analysis. | Zhang Y et al. | β | 2025 | β |
| The impact of metabolic syndrome on hepatocellular carcinoma: a mendelian randomization study. | Yuan C et al. | β | 2025 | β |
| Therapeutic targets for venous thromboemblism: proteome-wide mendelian randomization and colocalization analyses. | Li X et al. | β | 2025 | β |
| The relationship between cathepsins and nasopharyngeal carcinoma: a Mendelian randomization analysis. | Hu J et al. | β | 2025 | β |
| The relationship between smoking and recurrent aphthous stomatitis: A Mendelian randomization study. | Hu Y et al. | β | 2025 | β |
| The role of gut microbiota and plasma metabolites in osteoporosis: Insights from Mendelian randomization analysis. | Zhu W et al. | β | 2025 | β |
| The role of gut microbiota and plasma metabolites in ulcerative colitis: Insights from Mendelian randomization analysis. | Zheng X et al. | β | 2025 | β |
| UDP-Glucose Ceramide Glucosyltransferase Inhibition, Immune Cell Mediation, and Endometriosis Risk: A Mendelian Randomization Study. | Xue L et al. | β | 2025 | β |
| Unraveling the causal association between inflammatory bowel diseases and uveitis through mendelian randomization analysis. | Zhong M et al. | β | 2025 | β |
| Unveiling new insights into migraine risk stratification using machine learning models of adjustable risk factors. | Liu YC et al. | β | 2025 | β |
| Unveiling the Causal Relationship between Thyroid and Kidney Function: A Multivariable Mendelian Randomization. | Tsao HM et al. | β | 2025 | β |
| Unveiling the crucial role of glycosylation modification in lung adenocarcinoma metastasis through artificial neural network-based spatial multi-omics single-cell analysis and Mendelian randomization. | Zhang P et al. | β | 2025 | β |
| White blood cell traits and lung cancer risk: a two-sample mendelian randomization analysis. | Long K et al. | β | 2025 | β |
| Adiposity and Functional Outcome After Ischemic Stroke: A Mendelian Randomization Study | Wang M et al. | β | 2024 | β |
| A genetically informed study reveals modifiable pathways in skin cancer. | Qian H et al. | β | 2024 | β |
| Alzheimer's disease as a causal risk factor for diabetic retinopathy: a Mendelian randomization study. | Ouyang F et al. | β | 2024 | β |
| Alzheimer's disease increases the risk of erectile dysfunction independent of cardiovascular diseases: A mendelian randomization study. | Liao K et al. | β | 2024 | β |
| A Mendelian randomization study of genetic liability to cutaneous melanoma and sunburns. | Lu F et al. | β | 2024 | β |
| A Mendelian randomization study on the association of bone mineral density with periodontitis. | Yu Y et al. | β | 2024 | β |
| Aminotransferases as causal factors for metabolic syndrome: A bidirectional Mendelian randomization study. | Lingyu M et al. | β | 2024 | β |
| A multi-level investigation of the genetic relationship between gastroesophageal reflux disease and lung cancer. | Wu D et al. | β | 2024 | β |
| Anorexia and bulimia in relation to ulcerative colitis: a Mendelian randomization study. | Su Q et al. | β | 2024 | β |
| A Note on Modelling Bidirectional Feedback Loops in Mendelian Randomization Studies. | Hwang LD et al. | β | 2024 | β |
| Apolipoproteins, lipids, lipid-lowering drugs and risk of amyotrophic lateral sclerosis and frontotemporal dementia: a meta-analysis and Mendelian randomisation study. | Chalitsios CV et al. | β | 2024 | β |
| Assessing causality between chronic obstructive pulmonary disease with depression: A bidirectional Mendelian randomization study. | Liu A et al. | β | 2024 | β |
| Assessing causal links between age at menarche and adolescent mental health: a Mendelian randomisation study. | Askelund AD et al. | β | 2024 | β |
| Assessing the association between age at first sexual intercourse and migraine: a Mendelian randomization study. | Zhu G et al. | β | 2024 | β |
| Assessment of bidirectional relationships between frailty and acute respiratory distress syndrome: a bidirectional Mendelian Randomization study. | Chen Y et al. | β | 2024 | β |
| Assessment of circulating proteins in thyroid cancer: Proteome-wide Mendelian randomization and colocalization analysis. | Fan Q et al. | β | 2024 | β |
| Association between BMD and coronary artery calcification: an observational and Mendelian randomization study. | Lu H et al. | β | 2024 | β |
| Association between body fat distribution and age at menarche: a two sample Mendelian randomization study. | Xue P et al. | β | 2024 | β |
| Association between common chronic pulmonary diseases and lung cancer: Mendelian randomization analysis. | Zhang W et al. | β | 2024 | β |
| Association between dietary tea consumption and non-alcoholic fatty liver disease: a study based on Mendelian randomisation and National Health and Nutrition Examination Survey (2005-2018) association between tea and non-alcoholic fatty liver disease. | Liu S et al. | β | 2024 | β |
| Association between gastroesophageal reflux disease and metabolic syndrome: a bidirectional two-sample Mendelian randomization analysis. | He T et al. | β | 2024 | β |
| Association between gut microbiota and central retinal artery occlusion: A two-sample Mendelian randomization study. | Chen J et al. | β | 2024 | β |
| Association between gut microbiota and male infertility: a two-sample Mendelian randomization study. | Deng R et al. | β | 2024 | β |
| Association between idiopathic normal pressure hydrocephalus and Alzheimer's disease: a bidirectional Mendelian randomization study. | Hu Y et al. | β | 2024 | β |
| Association between levels of sex hormones and risk of multiple sclerosis: a mendelian randomization study. | Geng C et al. | β | 2024 | β |
| Association between migraine and venous thromboembolism: a Mendelian randomization and genetic correlation study. | Wu XP et al. | β | 2024 | β |
| Association between nonalcoholic fatty liver disease and bone mineral density: Mendelian randomization and mediation analysis. | Zheng M et al. | β | 2024 | β |
| Association between pulp and periapical disease with type 2 diabetes: A bidirectional Mendelian randomization. | Wang Y et al. | β | 2024 | β |
| Association Between Serum Galectin-3 and Parkinson's Disease: A Two-Sample Mendelian Randomization Study. | Pan R et al. | β | 2024 | β |
| Association between serum uric acid and deep venous thrombosis in European populations: A two-sample Mendelian randomization study. | Liu Y et al. | β | 2024 | β |
| Association of B cells and the risk of Esophageal cancer: a bidirectional two-sample mendelian randomization study. | Guo J et al. | β | 2024 | β |
| Association of birth weight with type 2 diabetes mellitus and the mediating role of fatty acids traits: a two-step mendelian randomization study. | Cao L et al. | β | 2024 | β |
| Association of Body Mass Index and Parkinson Disease: A Bidirectional Mendelian Randomization Study. | Domenighetti C et al. | β | 2024 | β |
| Association of congenital iodine deficiency syndrome and differentiated thyroid cancer: a Mendelian randomization study. | Liang K et al. | β | 2024 | β |
| Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19. | Rontogianni MO et al. | β | 2024 | β |
| Association of periodontitis with gastrointestinal tract disorders: A bidirectional Mendelian randomization study. | Wang Y et al. | β | 2024 | β |
| Association of Smoking with Chronic Kidney Disease Stages 3 to 5: A Mendelian Randomization Study. | Zhang Z et al. | β | 2024 | β |
| Associations between artificial sweetener intake from cereals, coffee, and tea and the risk of type 2 diabetes mellitus: A genetic correlation, mediation, and mendelian randomization analysis. | Zhang Y et al. | β | 2024 | β |
| Associations between chronic obstructive pulmonary disease and ten common cancers: novel insights from Mendelian randomization analyses. | Liao S et al. | β | 2024 | β |
| Associations between daytime napping, sleep duration, and depression and 15 cardiovascular diseases: a Mendelian randomization study. | Li Y et al. | β | 2024 | β |
| Associations Between Genetically Predicted Iron Status and Cardiovascular Disease Risk: A Mendelian Randomization Study. | Barad A et al. | β | 2024 | β |
| Associations between modifiable risk factors and hepatocellular carcinoma: a trans-ancestry Mendelian randomization study. | Wei X et al. | β | 2024 | β |
| Associations between type 2 diabetes mellitus and chronic liver diseases: evidence from a Mendelian randomization study in Europeans and East Asians. | Zhao Y et al. | β | 2024 | β |
| Associations of computer gaming with incident dementia, cognitive functions, and brain structure: a prospective cohort study and Mendelian randomization analysis. | Jia Y et al. | β | 2024 | β |
| Associations of lipids and lipid-modifying drug target genes with atrial fibrillation risk based on genomic data. | Tao Y et al. | β | 2024 | β |
| Associations of modifiable factors with risk of irritable bowel syndrome. | Chen Y et al. | β | 2024 | β |
| Asthma and risk of adverse pregnancy outcomes: A Mendelian randomization study. | Han X et al. | β | 2024 | β |
| Autoimmune diseases and their genetic link to bronchiectasis: insights from a genetic correlation and Mendelian randomization study. | Su Y et al. | β | 2024 | β |
| Bidirectional two-sample mendelian randomization analysis identifies causal associations of MRI-based cortical thickness and surface area relation to NAFLD. | Mao Z et al. | β | 2024 | β |
| Bi-directional two-sample Mendelian randomization identifies causal association of depression with temporomandibular disorders. | Que H et al. | β | 2024 | β |
| Blood metabolites mediate effects of breakfast skipping on heart failure via Mendelian randomization analysis. | Lv L et al. | β | 2024 | β |
| Body mass index, smoking behavior, and depression mediated the effects of schizophrenia on chronic obstructive pulmonary disease: trans-ethnic Mendelian-randomization analysis. | Ni Y et al. | β | 2024 | β |
| Body size and risk of colorectal cancer molecular defined subtypes and pathways: Mendelian randomization analyses. | Papadimitriou N et al. | β | 2024 | β |
| Causal association between 637 human metabolites and ovarian cancer: a mendelian randomization study. | Huang Y et al. | β | 2024 | β |
| Causal association between blood leukocyte counts and vascular dementia: a two-sample bidirectional Mendelian randomization study. | Liu S et al. | β | 2024 | β |
| Causal association between blood metabolites and abdominal aortic calcification: A bidirectional Mendelian randomization study. | Yang H et al. | β | 2024 | β |
| Causal association between blood metabolites and risk of hypertension: a Mendelian randomization study. | Cheng T et al. | β | 2024 | β |
| Causal Association Between Heart Failure and Sepsis: Insights from Mendelian Randomization and Observational Studies. | Liu L et al. | β | 2024 | β |
| Causal association between major depressive disorder and venous thromboembolism: a bidirectional mendelian randomization study. | Li HY et al. | β | 2024 | β |
| Causal association between pregnancy disorders and neonatal jaundice: a two-sample Mendelian randomization study. | Wang Y et al. | β | 2024 | β |
| Causal Association of Golgi Protein 73 With Coronary Artery Disease: Evidence from Proteomics and Mendelian Randomization. | Lin YF et al. | β | 2024 | β |
| Causal association of metabolic syndrome with chronic kidney disease progression: A Mendelian randomization study. | Guo Q et al. | β | 2024 | β |
| Causal association of plasma <i>n</i>-3 PUFA with peptic ulcer disease: a two-sample Mendelian randomisation study. | Dai Z et al. | β | 2024 | β |
| Causal associations between circulating inflammatory cytokines and blinding eye diseases: a bidirectional Mendelian randomization analysis. | Teng M et al. | β | 2024 | β |
| Causal Associations Between Lifestyle Habits and Risk of Benign Prostatic Hyperplasia: A Two-Sample Mendelian Randomization Study. | Jia F et al. | β | 2024 | β |
| Causal associations between liver enzymes and diabetic microvascular complications: A univariable and multivariable Mendelian randomization. | Li Y et al. | β | 2024 | β |
| Causal associations between osteoporosis and HBV infection across Asian and European populations: evidence from Mendelian randomization and colocalization analysis. | Li Z et al. | β | 2024 | β |
| Causal associations between rheumatoid arthritis, cataract and glaucoma in European and East Asian populations: A bidirectional two-sample mendelian randomization study. | Teng M et al. | β | 2024 | β |
| Causal associations between severe mental illness and sepsis: a Mendelian randomization study. | Yang R et al. | β | 2024 | β |
| Causal associations between systemic lupus erythematosus and primary biliary cholangitis: A bidirectional Mendelian randomization study. | Zhong M et al. | β | 2024 | β |
| Causal associations of particulate matter 2.5 and cardiovascular disease: A two-sample mendelian randomization study. | Cao Y et al. | β | 2024 | β |
| Causal effect of gut microbiota on the risk of prostatitis: a two-sample Mendelian randomization study. | Liu D et al. | β | 2024 | β |
| Causal Effect of Lipoprotein-Associated Phospholipase A2 Activity on Ischemic Stroke: A Mendelian Randomization Study. | Zhang Y et al. | β | 2024 | β |
| Causal Effects of Basal Metabolic Rate on Cardiovascular Disease: A Bidirectional Mendelian Randomization Study. | Zhao P et al. | β | 2024 | β |
| Causal effects of body mass index, education, and lifestyle behaviors on intervertebral disc disorders: Mendelian randomization study. | Liu C et al. | β | 2024 | β |
| Causal effects of genetically determined circulating metabolites on endometriosis: A Mendelian randomization study. | Liu L et al. | β | 2024 | β |
| Causal effects of genetic birth weight and gestational age on adult esophageal diseases: Mendelian randomization study. | Ruan LC et al. | β | 2024 | β |
| Causality Assessment Between Idiopathic Inflammatory Myopathies and Lung Cancer: A Bidirectional 2-Sample Mendelian Randomization. | Li H et al. | β | 2024 | β |
| Causality between alcohol usually taken with meals and Meniere disease: A 2-sample Mendelian randomization study. | Liu S et al. | β | 2024 | β |
| Causality between autoimmune diseases and breast cancer: a two-sample Mendelian randomization study in a European population. | Zhang H et al. | β | 2024 | β |
| Causality of inflammatory bowel disease and seborrheic keratosis: A bidirectional two-sample Mendelian randomization study. | Lin Z et al. | β | 2024 | β |
| Causal linkage of Graves' disease with aging: Mendelian randomization analysis of telomere length and age-related phenotypes. | Hu J et al. | β | 2024 | β |
| Causal link between gut microbiome and schizophrenia: a Mendelian randomization study. | Zeng Q et al. | β | 2024 | β |
| Causal Metabolomic and Lipidomic Analysis of Circulating Plasma Metabolites in Autism: A Comprehensive Mendelian Randomization Study with Independent Cohort Validation. | Li Z et al. | β | 2024 | β |
| Causal Relationship between Aging and Anorexia Nervosa: A White-Matter-Microstructure-Mediated Mendelian Randomization Analysis. | Qiu H et al. | β | 2024 | β |
| Causal relationship between blood traits and severe influenza A(H1N1)pdm09 infection in East Asian: A Mendelian randomization study. | Wang F et al. | β | 2024 | β |
| Causal relationship between coffee intake and neurological diseases: a Mendelian randomization study. | Zhang J et al. | β | 2024 | β |
| Causal relationship between dietary salt intake and dementia risk: Mendelian randomization study. | Shi K et al. | β | 2024 | β |
| Causal Relationship Between Ferritin and Neuropsychiatric Disorders: A Two-Sample Mendelian Randomization Study. | Sun W et al. | β | 2024 | β |
| Causal relationship between gut microbiota and risk of gastroesophageal reflux disease: a genetic correlation and bidirectional Mendelian randomization study. | Wang K et al. | β | 2024 | β |
| Causal relationship between inflammatory bowel disease and erythema nodosum: A two-sample bidirectional Mendelian randomization study. | Zhu H et al. | β | 2024 | β |
| Causal relationship between intervertebral disc degeneration and osteoporosis: a bidirectional two-sample Mendelian randomization study. | Liu G et al. | β | 2024 | β |
| Causal relationship between narcolepsy and anxiety: A two-sample Mendelian randomization study. | Geng C et al. | β | 2024 | β |
| Causal relationship between neuroticism and bone mineral density: A univariable and multivariable Mendelian randomization study. | Chen S et al. | β | 2024 | β |
| Causal relationship between the immune phenotype of monocytes and myasthenia gravis: A Mendelian randomization study. | Dong J et al. | β | 2024 | β |
| Causal relationship between type 2 diabetes and common respiratory system diseases: a two-sample Mendelian randomization analysis. | Chen J et al. | β | 2024 | β |
| Causal relationships between coffee intake, apolipoprotein B and gastric, colorectal, and esophageal cancers: univariable and multivariable Mendelian randomization. | Liu X et al. | β | 2024 | β |
| Causal relationships between dietary antioxidant vitamin intake and atopic dermatitis: A two-sample Mendelian randomization study. | Wang S et al. | β | 2024 | β |
| Causal relationships between dyslexia and the risk of eight dementias. | Zhu P et al. | β | 2024 | β |
| Causal relationships between gut microbiota, immune cell, and Non-small cell lung cancer: a two-step, two-sample Mendelian randomization study. | Chen J et al. | β | 2024 | β |
| Causal relationships between lung cancer and sepsis: a genetic correlation and multivariate mendelian randomization analysis. | Zhou J et al. | β | 2024 | β |
| Causal relationships between mitochondrial proteins and different pathological types of lung cancer: a bidirectional mendelian randomization study. | Ji T et al. | β | 2024 | β |
| Causal relationships between plasma lipidome and diabetic neuropathy: a Mendelian randomization study. | Wang Z et al. | β | 2024 | β |
| Causal relationships exist between polycystic ovary syndrome and adverse pregnancy and perinatal outcomes: a Mendelian randomization study. | Ma Y et al. | β | 2024 | β |
| Causal relationships of familial hypercholesterolemia with the risk of multiple vitamin deficiencies: a Mendelian randomization study. | Zhang C et al. | β | 2024 | β |
| Causal role of immune cells on risk of Parkinson's disease: a Mendelian randomization study. | Gu J et al. | β | 2024 | β |
| Celiac disease and attention-deficit/hyperactivity disorder: a bidirectional Mendelian randomization analysis. | Chen J et al. | β | 2024 | β |
| Circulating 25-hydroxyvitamin D and survival outcomes of colorectal cancer: evidence from population-based prospective cohorts and Mendelian randomisation. | Zhang X et al. | β | 2024 | β |
| Circulating inflammatory biomarkers and risk of intracranial aneurysm: a Mendelian randomization study. | Fang J et al. | β | 2024 | β |
| Circulating levels of cytokines and risk of urologic cancers: a two-sample Mendelian randomization study. | Song J et al. | β | 2024 | β |
| Circulating Levels of T-Cell Traits and the Risk of Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study. | Lu T et al. | β | 2024 | β |
| Circulating micronutrient levels and their association with sepsis susceptibility and severity: a Mendelian randomization study. | Wei Z et al. | β | 2024 | β |
| Commentary: Causal relationship between particulate matter 2.5 and diabetes: two sample Mendelian randomization. | Ni Y et al. | β | 2024 | β |
| Commentary: "No Genetic Causality between Tobacco Smoking and Venous Thromboembolism: A Two-Sample Mendelian Randomization Study". | Liu J et al. | β | 2024 | β |
| Commentary: The causal effect of hypertension, intraocular pressure, and diabetic retinopathy: a Mendelian randomization study. | Zhang Y et al. | β | 2024 | β |
| Comment on "Cholesterol and low-density lipoprotein as a cause of psoriasis: Results from bidirectional Mendelian randomization". | Ni Y et al. | β | 2024 | β |
| COVID-19 and Parkinson's disease: a single-center study and Mendelian randomization study. | Yin J et al. | β | 2024 | β |
| Critically-ill COVID-19 susceptibility gene CCR3 shows natural selection in sub-Saharan Africans. | Sun Z et al. | β | 2024 | β |
| CRP, IL-1Ξ±, IL-1Ξ², and IL-6 levels and the risk of breast cancer: a two-sample Mendelian randomization study. | Cui Y et al. | β | 2024 | β |
| CYP2A6 Activity and Cigarette Consumption Interact in Smoking-Related Lung Cancer Susceptibility. | Du M et al. | β | 2024 | β |
| Dark chocolate intake and cardiovascular diseases: a Mendelian randomization study. | Yang J et al. | β | 2024 | β |
| Defining predictors of responsiveness to advanced therapies in Crohn's disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine. | Wyatt NJ et al. | β | 2024 | β |
| Depression and risk of infectious diseases: A mendelian randomization study. | Shi L et al. | β | 2024 | β |
| Dietary habit and risk of rheumatoid arthritis: a mendelian randomization study identifying protective and risk factors. | Li J et al. | β | 2024 | β |
| Dissecting causal links between gut microbiota, inflammatory cytokines, and DLBCL: a Mendelian randomization study. | Jiang P et al. | β | 2024 | β |
| Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study. | Xue K et al. | β | 2024 | β |
| Dissecting the causal relationship between moderate to vigorous physical activity levels and cognitive performance: a bidirectional two-sample Mendelian randomization study. | Fang Q et al. | β | 2024 | β |
| Does gestational diabetes mellitus increase the risk of cardiovascular disease? A Mendelian randomization study. | Liang W et al. | β | 2024 | β |
| Drug repurposing opportunities for chronic kidney disease. | Chen X et al. | β | 2024 | β |
| Effect of the Blood Pressure and Antihypertensive Drugs on Cerebral Small Vessel Disease: A Mendelian Randomization Study. | Ma Y et al. | β | 2024 | β |
| Effects of circulating inflammatory proteins on osteoporosis and fractures: evidence from genetic correlation and Mendelian randomization study. | Zheng Q et al. | β | 2024 | β |
| Elevated serum LDL-C increases the risk of Lewy body dementia: a two-sample mendelian randomization study. | Liu P et al. | β | 2024 | β |
| Evaluating causal influence of maternal educational attainment on offspring birthweight via observational study and Mendelian randomization analyses. | Zhu Y et al. | β | 2024 | β |
| Evaluating causal influence of serum uric acid on psoriasis via observational study and transethnic Mendelian randomization analyses. | Zhao D et al. | β | 2024 | β |
| Evaluating the relationship between glycemic control and bone fragility within the UK Biobank: observational and one-sample Mendelian randomization analyses. | Ghatan S et al. | β | 2024 | β |
| Evaluation of the causal effects of blood metabolites on irritable bowel syndrome: Mendelian randomization. | Zeng Y et al. | β | 2024 | β |
| Exploring biomarkers of Alzheimer's disease based on multi-omics and Mendelian randomisation analysis. | Tu K et al. | β | 2024 | β |
| Exploring correlations between immune cell phenotypes and the risk of epilepsy: A bidirectional Mendelian randomization study. | Chen Z et al. | β | 2024 | β |
| Exploring genetic links between blood metabolites and gout susceptibility. | Zeng W et al. | β | 2024 | β |
| Exploring Sex Differences in Pain Manifestation of Coronary Artery Disease through Mendelian Randomization. | Methorst R et al. | β | 2024 | β |
| Exploring Stroke Risk through Mendelian Randomization: A Comprehensive Study Integrating Genetics and Metabolic Traits in the Korean Population. | Ban HJ et al. | β | 2024 | β |
| Exploring the Causal Association between Morning Diurnal Preference and Psychiatric Disorders: A Bidirectional Two-Sample Mendelian Randomization Analysis. | Chen M et al. | β | 2024 | β |
| Exploring the causal effect between lipid-modifying drugs and idiopathic pulmonary fibrosis: a drug-target Mendelian randomization study. | Cai G et al. | β | 2024 | β |
| Exploring the causal effect of omega-3 polyunsaturated fatty acid levels on the risk of type 1 diabetes: a Mendelian randomization study. | Abolo L et al. | β | 2024 | β |
| Exploring the causality of appendectomy and ischaemic heart disease: a Mendelian randomization study and meta-analysis. | Wang S et al. | β | 2024 | β |
| Exploring the causal relationship between Takayasu arteritis and inflammatory bowel disease using Mendelian randomization. | Pang X et al. | β | 2024 | β |
| Exploring the contribution of lifestyle to the impact of education on the risk of cancer through Mendelian randomization analysis. | Zagkos L et al. | β | 2024 | β |
| Exploring the cross-cancer effect of circulating proteins and discovering potential intervention targets for 13 site-specific cancers. | Sun J et al. | β | 2024 | β |
| Exploring the potential causal effects of food preferences on irritable bowel syndrome risk: A two-sample Mendelian randomization study. | Zhang T et al. | β | 2024 | β |
| Exploring the potential link between gut microbiota and chronic kidney disease in causality: A 2-sample Mendelian randomization study. | Zhang WW et al. | β | 2024 | β |
| Exploring the relationship between anal fistula and colorectal cancer based on Mendelian randomization and bioinformatics. | Liu Y et al. | β | 2024 | β |
| Exploring the therapeutic potential of interleukin-6 receptor blockade in autoimmune diseases using drug target mendelian randomization. | Li J et al. | β | 2024 | β |
| Fibroblast growth factor 23-mediated regulation of osteoporosis: Assessed via Mendelian randomization and inΒ vitro study. | Zhang X et al. | β | 2024 | β |
| Gastroesophageal Reflux Disease and Preterm Birth: Univariate and Multivariate Mendelian Randomization. | Han X et al. | β | 2024 | β |
| Gastroesophageal reflux disease increases the risk of essential hypertension: results from the Nationwide Readmission Database and Mendelian randomization analysis. | Yao Z et al. | β | 2024 | β |
| Gastroesophageal reflux disease increases the risk of rheumatoid arthritis: a bidirectional two-sample Mendelian randomization study. | Yuan Q et al. | β | 2024 | β |
| Gastroesophageal reflux disease may causally associate with the increased atrial fibrillation risk: evidence from two-sample Mendelian randomization analyses. | Wang L et al. | β | 2024 | β |
| Gene prediction of the causal relationship between immune cells and IgA nephropathy: A bidirectional Mendelian randomization study. | Zhang Y et al. | β | 2024 | β |
| Genetically determined circulating micronutrients and the risk of nonalcoholic fatty liver disease. | Liu K et al. | β | 2024 | β |
| Genetically Determined Plasma Hepatocyte Growth Factor Levels Are Associated With the Risk and Prognosis of Ischemic Stroke. | Xu Q et al. | β | 2024 | β |
| Genetically identification of endometriosis and cancers risk in women through a two-sample Mendelian randomization study. | Zhang L et al. | β | 2024 | β |
| Genetically predicted blood metabolites mediate relationships between gut microbiota and ovarian cancer: a Mendelian randomization study. | Zhang L et al. | β | 2024 | β |
| Genetically predicted causality between gut microbiota, blood metabolites, and intracerebral hemorrhage: a bidirectional Mendelian randomization study. | Zhang T et al. | β | 2024 | β |
| Genetically predicted high serum sex hormone-binding globulin levels are associated with lower ischemic stroke risk: A sex-stratified Mendelian randomization study. | Sun W et al. | β | 2024 | β |
| Genetically predicted plasma cortisol and common chronic diseases: A Mendelian randomization study. | Lee WH et al. | β | 2024 | β |
| Genetically Proxied Antidiabetic Drug Target and Primary Open-Angle Glaucoma: A Mendelian Randomization Study. | Tang K et al. | β | 2024 | β |
| Genetically proxied appendicular lean mass and stroke risk: A two-step mendelian randomization study. | Li Z et al. | β | 2024 | β |
| Genetic analyses identify brain imaging-derived phenotypes associated with the risk of amyotrophic lateral sclerosis. | Wang Y et al. | β | 2024 | β |
| Genetic analyses identify brain imaging-derived phenotypes associated with the risk of intracerebral hemorrhage. | Liu Y et al. | β | 2024 | β |
| Genetic analyses identify evidence for a causal relationship between Ewing sarcoma and hernias. | Yang T et al. | β | 2024 | β |
| Genetic association of serum lipids and lipid-modifying targets with endometriosis: Trans-ethnic Mendelian-randomization and mediation analysis. | Zhang H et al. | β | 2024 | β |
| Genetic association of type 2 diabetes and antidiabetic drug target with skin cancer. | Zhao J et al. | β | 2024 | β |
| Genetic correlation and causal associations between circulating C-reactive protein levels and lung cancer risk. | Shi J et al. | β | 2024 | β |
| Genetic Evidence for a Causal Relationship Between Innate Leukocytes and the Risk of Digestive System Cancers in East Asians and Europeans. | Zhu JH et al. | β | 2024 | β |
| Genetic evidence for causal association between migraine and dementia: a mendelian randomization study. | Chen Q et al. | β | 2024 | β |
| Genetic evidence strengthens the bidirectional connection between gut microbiota and <i>Shigella</i> infection: insights from a two-sample Mendelian randomization study. | Peng J et al. | β | 2024 | β |
| Genetic evidence strengthens the connection between gut microbiota and gingivitis: a two-sample Mendelian randomization study. | Hang Z et al. | β | 2024 | β |
| Genetic insights into repurposing statins for hyperthyroidism prevention: a drug-target Mendelian randomization study. | Huang A et al. | β | 2024 | β |
| Genetic liability to frailty in relation to functional outcome after ischemic stroke. | Cai H et al. | β | 2024 | β |
| Genetic prediction of blood metabolites mediating the relationship between gut microbiota and Alzheimer's disease: a Mendelian randomization study. | Chen G et al. | β | 2024 | β |
| Genetic prediction of micronutrient levels and the risk of colorectal polyps: A mendelian randomization study. | Lv S et al. | β | 2024 | β |
| Genetic prediction of the relationship between metabolic syndrome and colorectal cancer risk: a Mendelian randomization study. | Yuan C et al. | β | 2024 | β |
| Genetic Risk of Ankylosing Spondylitis and Second-Line Therapy Need in Crohn's Disease: A Mendelian Randomization Study. | Omar M et al. | β | 2024 | β |
| Genetic susceptibility and causal pathway analysis of eye disorders coexisting in multiple sclerosis. | Qiu X et al. | β | 2024 | β |
| Genome-wide association and Mendelian randomisation analysis among 30,699 Chinese pregnant women identifies novel genetic and molecular risk factors for gestational diabetes and glycaemic traits. | Zhen J et al. | β | 2024 | β |
| Gestational diabetes and future cardiovascular diseases: associations by sex-specific genetic data. | Zhang Y et al. | β | 2024 | β |
| Glycemic traits and colorectal cancer survival in a cohort of South Korean patients: A Mendelian randomization analysis. | Jun SY et al. | β | 2024 | β |
| Gut Microbiome and Stroke: a Bidirectional Mendelian Randomisation Study in East Asian and European Populations. | Cheng S et al. | β | 2024 | β |
| Gut microbiota influence on lung cancer risk through blood metabolite mediation: from a comprehensive Mendelian randomization analysis and genetic analysis. | Du Y et al. | β | 2024 | β |
| High SHBG and Low Bioavailable Testosterone are Strongly Causally Associated with Increased Forearm Fracture Risk in Women: An MR Study Leveraging Novel Female-Specific Data. | Quester J et al. | β | 2024 | β |
| Human Papillomavirus Infection and Autoimmune Diseases: A Two-Sample Bidirectional Mendelian Randomization Study. | He T et al. | β | 2024 | β |
| Hyperglycaemia, diabetes and risk of fragility fractures: observational and Mendelian randomisation studies. | Emanuelsson F et al. | β | 2024 | β |
| Hypothyroidism is a causal determinant of age-related cataract risk in European population: a Mendelian randomization study. | Liu S et al. | β | 2024 | β |
| Identification of the VLDLR locus associated with giant cell arteritis and the possible causal role of low-density lipoprotein cholesterol in its pathogenesis. | Iwasaki T et al. | β | 2024 | β |
| Identifying depression's genetic role as a precursor to sepsis and increased mortality risk: Comprehensive insights from mendelian randomization analysis. | Zhou Q et al. | β | 2024 | β |
| Identifying Potential Causal Effects of Telomere Length on Health Outcomes: A Phenome-Wide Investigation and Mendelian Randomization Study. | Wang W et al. | β | 2024 | β |
| Identifying potential repurposable medications for Parkinson's disease through Mendelian randomization analysis. | Wang Q et al. | β | 2024 | β |
| Identifying the association between depression and constipation: An observational study and Mendelian randomization analysis. | Wu S et al. | β | 2024 | β |
| IL-20RA is Associated with the Risk of Diabetic Microangiopathy: A Bidirectional Mendelian Randomization Analysis and Clinical Validation. | Li J et al. | β | 2024 | β |
| Inflammatory bowel disease and allergic diseases: A Mendelian randomization study. | Li J et al. | β | 2024 | β |
| Inflammatory Conditions During Pregnancy and Risk of Autism and Other Neurodevelopmental Disorders. | Croen LA et al. | β | 2024 | β |
| Integration of QTL and comprehensive analysis in the circulating inflammatory cytokines for pan-cancer. | Lin H et al. | β | 2024 | β |
| Intestinal flora and inflammatory bowel disease: Causal relationships and predictive models. | Bi GW et al. | β | 2024 | β |
| Investigating causal associations between pneumonia and lung cancer using a bidirectional mendelian randomization framework. | Song L et al. | β | 2024 | β |
| Investigating Causal Effects of Hematologic Traits on Lung Cancer: A Mendelian Randomization Study. | Yang Z et al. | β | 2024 | β |
| Investigating the association of the effect of genetically proxied PCSK9i with mood disorders using cis-pQTLs: A drug-target Mendelian randomization study. | Aman A et al. | β | 2024 | β |
| Investigating the Bidirectional Association of Rheumatoid Arthritis and Thyroid Function: A Methodologic Assessment of Mendelian Randomization. | Tan Y et al. | β | 2024 | β |
| Investigating the causal associations between five anthropometric indicators and nonalcoholic fatty liver disease: Mendelian randomization study. | Xiao XP et al. | β | 2024 | β |
| Investigating the causal relationship between major depressive disorder and benign prostatic hyperplasia: a bidirectional Mendelian randomisation study. | Zheng G et al. | β | 2024 | β |
| Investigating the uncertain causal link between gut microbiota and glaucoma: A genetic correlation and Mendelian randomisation study. | Li J et al. | β | 2024 | β |
| Investigation of causal effects of blood metabolites on insomnia and circadian rhythm sleep wake disorders. | Lv Z et al. | β | 2024 | β |
| Investigation of the Association between Air Pollution and Non-Alcoholic Fatty Liver Disease in the European Population: A Mendelian Randomization Study. | Yang J et al. | β | 2024 | β |
| Iron status and sarcopenia-related traits: a bi-directional Mendelian randomization study. | Chen H et al. | β | 2024 | β |
| Is there a causal association between gestational diabetes mellitus and immune mediators? A bidirectional Mendelian randomization analysis. | Ji Z et al. | β | 2024 | β |
| <i>Toxoplasma gondii</i> infection and brain inflammation: A two-sample mendelian randomization analysis. | Yao Y et al. | β | 2024 | β |
| Lactobacillaceae-mediated eye-brain-gut axis regulates high myopia-related anxiety: from the perspective of predictive, preventive, and personalized medicine. | Mi Y et al. | β | 2024 | β |
| Large-scale bidirectional Mendelian randomization study identifies new gut microbiome significantly associated with immune thrombocytopenic purpura. | Li J et al. | β | 2024 | β |
| Leisure time television watching, computer use and risks of breast, colorectal and prostate cancer: A Mendelian randomisation analysis. | Papadimitriou N et al. | β | 2024 | β |
| Letter to the Editor on "Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study". | Zhang Y et al. | β | 2024 | β |
| Limited Clinical Impact of Genetic Associations between Celiac Disease and Type 2 Inflammatory Diseases: Insights from Mendelian Randomization. | Omar M et al. | β | 2024 | β |
| Lipids and Statin Medication With Sensorineural Hearing Loss: A Mendelian Randomization Study. | Wu H et al. | β | 2024 | β |
| Lipoprotein lipids and apolipoproteins in primary immune thrombocytopenia: Results from a clinical characteristics and causal relationship verification, potential drug target identification by Mendelian randomization analyses. | Ou Y et al. | β | 2024 | β |
| Low-density lipoprotein cholesterol and the risk of hyperemesis gravidarum: a Mendelian randomization study. | Liu X et al. | β | 2024 | β |
| Mediating role of circulating inflammatory proteins in the effect of immune cells on esophageal cancer risk: A Mendelian randomization study. | Guo J et al. | β | 2024 | β |
| Mendelian randomization analyses clarify the effects of height on cardiovascular diseases. | Hui D et al. | β | 2024 | β |
| Mendelian randomization analyses reveal no genetic causal effects of major adipokines on systemic lupus erythematosus. | Duan P et al. | β | 2024 | β |
| Mendelian randomization analysis reveals causality of inflammatory bowel disease on risks of Henoch-SchΓΆnlein purpura and immune thrombocytopenia. | Li H et al. | β | 2024 | β |
| Mendelian randomization: causal inference leveraging genetic data. | Chen LG et al. | β | 2024 | β |
| Mendelian randomization identifies circulating proteins as biomarkers for age at menarche and age at natural menopause. | Yazdanpanah N et al. | β | 2024 | β |
| Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease. | Ramadan FA et al. | β | 2024 | β |
| Mendelian randomization of circulating proteome identifies IFN-Ξ³ as a druggable target in aplastic anemia. | Qin S et al. | β | 2024 | β |
| Mendelian randomization study of urolithiasis: exploration of risk factors using human blood metabolites. | Hu D et al. | β | 2024 | β |
| Metabolic-dysfunction associated steatotic liver disease-related diseases, cognition and dementia: A two-sample mendelian randomization study. | Li YS et al. | β | 2024 | β |
| Metabolic Traits and Risk of Ischemic Stroke in Japanese and European Populations: A Two-Sample Mendelian Randomization Study. | Zhang J et al. | β | 2024 | β |
| Metabolomics signature of blood pressure salt sensitivity and its link to cardiovascular disease: A dietary salt-intervention trial. | Lin Z et al. | β | 2024 | β |
| Micronutrients and Major Depression: A Mendelian Randomisation Study. | Carnegie RE et al. | β | 2024 | β |
| Migraine and gastroesophageal reflux disease: Disentangling the complex connection with depression as a mediator. | Shen Z et al. | β | 2024 | β |
| Navigating Mendelian Randomization in Sleep Medicine: Challenges, Opportunities, and Best Practices. | BaHammam AS et al. | β | 2024 | β |
| No bidirectional relationship between sleep phenotypes and risk of proliferative diabetic retinopathy: a two-sample Mendelian randomization study. | Liu H et al. | β | 2024 | β |
| Non-targeted metabolomics revealed novel links between serum metabolites and primary ovarian insufficiency: a Mendelian randomization study. | Chen S et al. | β | 2024 | β |
| Obesity and risk for liver disease: a two-sample Mendelian randomisation study. | An W et al. | β | 2024 | β |
| Observational and genetic analyses of the bidirectional relationship between depression and hypertension. | Xu Z et al. | β | 2024 | β |
| Obstructive sleep apnea and mental disorders: a bidirectional mendelian randomization study. | Liu H et al. | β | 2024 | β |
| Periodontitis and Sjogren's syndrome: a bidirectional two-sample mendelian randomization study. | Liu Y et al. | β | 2024 | β |
| Peripheral blood indicators and COVID-19: anΒ observationalΒ andΒ bidirectional MendelianΒ randomizationΒ study. | Chang Z et al. | β | 2024 | β |
| Phenome-wide Mendelian randomisation analysis of 378,142 cases reveals risk factors for eight common cancers. | Went M et al. | β | 2024 | β |
| Plasma fatty acids and attention deficit hyperactivity disorder: a Mendelian randomization investigation. | Zhou K et al. | β | 2024 | β |
| Plasma homocysteine level, estradiol level, and brain atrophy: a Mendelian randomization study. | Gao W et al. | β | 2024 | β |
| Plasma metabolites and risk of seven cancers: a two-sample Mendelian randomization study among European descendants. | Chen Y et al. | β | 2024 | β |
| Plasma metabolome mediates the causal relationship between immune cells and heart failure: a two-step bidirectional Mendelian randomization study. | Li T et al. | β | 2024 | β |
| Plasma Proteomic Signature Predicts Myeloid Neoplasm Risk. | Tran D et al. | β | 2024 | β |
| PM2.5 associates with blood pressure: a Mendelian randomization analysis. | Bao M et al. | β | 2024 | β |
| Polyunsaturated fatty acids and diabetic microvascular complications: a Mendelian randomization study. | Liu B et al. | β | 2024 | β |
| Prescription glucocorticoid medication and iridocyclitis are associated with an increased risk of senile cataract occurrence: a Mendelian randomization study. | Wen R et al. | β | 2024 | β |
| Prospective study on the association between 36 human blood cell traits and pan-cancer outcomes: a mendelian randomization analysis. | Liang J et al. | β | 2024 | β |
| Proteome-wide Mendelian randomization and therapeutic targets for bladder cancer. | Wu MH et al. | β | 2024 | β |
| Relationship between socioeconomic status and stroke: An observational and network Mendelian randomization study. | Zhang R et al. | β | 2024 | β |
| Relationships between heart failure, depression, and anxiety: A Mendelian randomization study. | Chen X et al. | β | 2024 | β |
| Repurposing antihypertensive drugs for pain disorders: a drug-target mendelian randomization study. | Du K et al. | β | 2024 | β |
| Risk of Parkinson's disease and depression severity in different populations: A two-sample Mendelian randomization analysis. | Qin Y et al. | β | 2024 | β |
| Roles of gut microbiota in androgenetic alopecia: insights from Mendelian randomization analysis. | Fu H et al. | β | 2024 | β |
| S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure. | Ma J et al. | β | 2024 | β |
| SGLT2 inhibition, blood lipids, and cardiovascular disease: A Mendelian randomization study. | Li J et al. | β | 2024 | β |
| Smoking behaviors, physical activities, pulmonary diseases and COVID-19 severity: A Mendelian randomization study. | Zheng X et al. | β | 2024 | β |
| Strengthening the Evidence for a Causal Link between Type 2 Diabetes Mellitus and Pancreatic Cancer: Insights from Two-Sample and Multivariable Mendelian Randomization. | Ke TM et al. | β | 2024 | β |
| The association between METS-IR, an indirect index for insulin resistance, and lung cancer risk. | Wang G et al. | β | 2024 | β |
| The association between the basal metabolic rate and cardiovascular disease: A two-sample Mendelian randomization study. | Chen K et al. | β | 2024 | β |
| The Associations Among Gut Microbiota, Branched Chain Amino Acids, and Parkinson's Disease: Mendelian Randomization Study. | Yan Z et al. | β | 2024 | β |
| The associations between dysregulation of human blood metabolites and lung cancer risk: evidence from genetic data. | Wu G et al. | β | 2024 | β |
| The causal association between circulating cytokines with the risk of frailty and sarcopenia under the perspective of geroscience. | Wang C et al. | β | 2024 | β |
| The causal association between serum metabolites and lung cancer based on multivariate Mendelian randomization. | Sun T et al. | β | 2024 | β |
| The Causal Associations between Adipokines and Alzheimer's Disease: A Two-Sample Mendelian Randomization Study. | Cai X et al. | β | 2024 | β |
| The causal associations of circulating lipids with Barrett's Esophagus and Esophageal Cancer: a bi-directional, two sample mendelian randomization analysis. | Li B et al. | β | 2024 | β |
| The causal effect of obesity on concomitant exotropia: A lifecourse Mendelian randomization study. | Liu C et al. | β | 2024 | β |
| The causal effect of telomere length on the risk of malignant lymphoma: A Mendelian randomization study. | Song T et al. | β | 2024 | β |
| The causal effects of genetically predicted alcohol consumption on endometrial cancer risk from a Mendelian randomization study. | Yang J et al. | β | 2024 | β |
| The causality between use of glucocorticoids and risk of pancreatitis: a Mendelian randomization study. | Lin W et al. | β | 2024 | β |
| The causal relationship between gut microbiota and biliary tract cancer: comprehensive bidirectional Mendelian randomization analysis. | Wang K et al. | β | 2024 | β |
| The causal relationship between human blood metabolites and the risk of visceral obesity: a mendelian randomization analysis. | Wang Z et al. | β | 2024 | β |
| The causal relationship between immune cells and diabetic retinopathy: a Mendelian randomization study. | Ye Y et al. | β | 2024 | β |
| The causal relationship between major depression disorder and thyroid diseases: A Mendelian randomization study and mediation analysis. | Zhang X et al. | β | 2024 | β |
| The causal relationship between type 2 diabetes mellitus and isolated REM sleep behavior disorder: results from multivariable and network Mendelian randomization analysis. | Zhang RY et al. | β | 2024 | β |
| The Causal Role of Thyroid Hormones in Bipolar Disorders: A Two-Sample Mendelian Randomization Study. | Li JL | β | 2024 | β |
| The effect of coffee consumption on three main bone disorders: a Mendelian randomization trial. | Zhang X et al. | β | 2024 | β |
| The effect of metabolism-related lifestyle and clinical risk factors on digestive system cancers in East Asian populations: a two-sample Mendelian randomization analysis. | Cai X et al. | β | 2024 | β |
| The effect of metformin on urate metabolism: Findings from observational and Mendelian randomization analyses. | Dai H et al. | β | 2024 | β |
| The Effect of Rheumatoid Arthritis on Features Associated with Sarcopenia: A Mendelian Randomization Study. | Ding K et al. | β | 2024 | β |
| The genetic causal association between hip or knee osteoarthritis and frailty: a two-sample Mendelian randomization analysis. | Zhou J et al. | β | 2024 | β |
| The gut-lung axis: Mendelian randomization identifies a causal association between inflammatory bowel disease and interstitial lung disease. | Zhang Y et al. | β | 2024 | β |
| The impact of bone mineral density on the risk of falling: evidence from genetic correlation and Mendelian randomization analysis. | Mao R et al. | β | 2024 | β |
| The impact of serum uric acid on psoriasis: NHANES 2005-2014 and Mendelian randomization. | Hu M et al. | β | 2024 | β |
| The Influence of Autoimmune Thyroid Diseases on Viral Pneumonia Development, Including COVID-19: A Two-Sample Mendelian Randomization Study. | Yi K et al. | β | 2024 | β |
| The Potential Causal Association of Apolipoprotein A and B and Age-Related Macular Degeneration: A Mendelian Randomisation Study. | Lee Y et al. | β | 2024 | β |
| The potential protective role of peripheral immunophenotypes in Alzheimer's disease: a Mendelian randomization study. | Zuo CY et al. | β | 2024 | β |
| The protective role of oily fish intake against type 2 diabetes: insights from a genetic correlation and Mendelian randomization study. | Zhang Y et al. | β | 2024 | β |
| The protective role of water intake in age-related eye diseases: insights from a Mendelian randomization study. | Mi Y et al. | β | 2024 | β |
| The relationship between human blood metabolites and preeclampsia-eclampsia: A Mendelian randomization study. | Wei J et al. | β | 2024 | β |
| The risk of Alzheimer's disease and cognitive impairment characteristics in eight mental disorders: A UK Biobank observational study and Mendelian randomization analysis. | Liu Y et al. | β | 2024 | β |
| Unraveling the connection between Hashimoto's Thyroiditis and non-alcoholic fatty liver disease: exploring the role of CD4<sup>+</sup>central memory T cells through integrated genetic approaches. | Li D et al. | β | 2024 | β |
| Unraveling the mechanisms of NK cell dysfunction in aging and Alzheimer's disease: insights from GWAS and single-cell transcriptomics. | Li J et al. | β | 2024 | β |
| Unravel the distinct effects of adiposity at different life stages on COVID-19 susceptibility and severity: A life-course Mendelian randomization study. | Xiao P et al. | β | 2024 | β |
| Unveiling Atherosclerotic Plaque Heterogeneity and SPP1<sup>+</sup>/VCAN<sup>+</sup> Macrophage Subtype Prognostic Significance Through Integrative Single-Cell and Bulk-Seq Analysis. | Xu X et al. | β | 2024 | β |
| Unveiling genetic links between gut microbiota and asthma: a Mendelian randomization. | Zheng X et al. | β | 2024 | β |
| Using genetic variations to reveal the complex relationships between vegetarianism and well-being, depressive symptoms and neuroticism. | Chen K et al. | β | 2024 | β |
| Visceral and ectopic fat are more predictively associated with primary liver cancer than overall obesity from genetic sights: A Mendelian randomization study. | Xu FQ et al. | β | 2024 | β |
| Absence of causal relationship between Parkinson's disease and subsequent prostate cancer: evidence from meta-analysis and Mendelian randomization studies. | Wang L et al. | β | 2023 | β |
| A Causal Atlas on Comorbidities in Idiopathic Pulmonary Fibrosis: A Bidirectional Mendelian Randomization Study. | Zhu J et al. | β | 2023 | β |
| A genome-wide cross-trait analysis identifies genomic correlation, pleiotropic loci, and causal relationship between sex hormone-binding globulin and rheumatoid arthritis. | Jiang Y et al. | β | 2023 | β |
| A large-scale genome-wide cross-trait analysis for the effect of COVID-19 on female-specific cancers. | Zhao X et al. | β | 2023 | β |
| A large-scale plasma proteome Mendelian randomization study identifies novel causal plasma proteins related to primary biliary cholangitis. | Yang H et al. | β | 2023 | β |
| Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism: a Mendelian randomisation study. | de Klerk JA et al. | β | 2023 | β |
| A Mendelian randomization study on causal effects of 25(OH) vitamin D levels on diabetic nephropathy. | He M et al. | β | 2023 | β |
| Among men, androgens are associated with a decrease in Alzheimer's disease risk. | Kusters CDJ et al. | β | 2023 | β |
| Amyotrophic lateral sclerosis and osteoporosis: a two-sample Mendelian randomization study. | Li J et al. | β | 2023 | β |
| An atlas of associations between 14 micronutrients and 22 cancer outcomes: Mendelian randomization analyses. | Kim JY et al. | β | 2023 | β |
| An atlas of genetic determinants of forearm fracture. | Nethander M et al. | β | 2023 | β |
| Ankylosing spondylitis: acute/subacute vs. chronic iridocyclitis - a bidirectional two-sample Mendelian randomization study. | Li H et al. | β | 2023 | β |
| Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study. | Chen J et al. | β | 2023 | β |
| Assessing causal relationships between gut microbiota and asthma: evidence from two sample Mendelian randomization analysis. | Li R et al. | β | 2023 | β |
| Assessing the causal relationship between genetically determined inflammatory biomarkers and low back pain risk: a bidirectional two-sample Mendelian randomization study. | Li W et al. | β | 2023 | β |
| Assessing the genetic relationship between gastroesophageal reflux disease and chronic respiratory diseases: a mendelian randomization study. | Cheng X et al. | β | 2023 | β |
| Assessment of bidirectional relationships between circulating cytokines and periodontitis: Insights from a mendelian randomization analysis. | Huang SJ et al. | β | 2023 | β |
| Assessment of causal associations among gut microbiota, metabolites, and celiac disease: a bidirectional Mendelian randomization study. | Li T et al. | β | 2023 | β |
| Assessment of the bidirectional causal association between frailty and depression: A Mendelian randomization study. | Zhu J et al. | β | 2023 | β |
| Association between allergic rhinitis and hypertension risk: A bidirectional 2-sample mendelian randomization study. | Zhang Y et al. | β | 2023 | β |
| Association between circulating 25-hydroxyvitamin D metabolites and periodontitis: Results from the NHANES 2009-2012 and Mendelian randomization study. | Li W et al. | β | 2023 | β |
| Association between circulating fatty acid metabolites and asthma risk: a two-sample bidirectional Mendelian randomization study. | Huang T et al. | β | 2023 | β |
| Association between COVID-19 and myasthenia gravis (MG): A genetic correlation and Mendelian randomization study. | Sun D et al. | β | 2023 | β |
| Association between genetically predicted rheumatoid arthritis and alopecia areata: a two-sample Mendelian randomization study. | Zhong S et al. | β | 2023 | β |
| Association Between Glycemic Traits and Primary Open-Angle Glaucoma: A Mendelian Randomization Study in the Japanese Population. | Hanyuda A et al. | β | 2023 | β |
| Association between gut microbiota and sensorineural hearing loss: a Mendelian randomization study. | Yin Q et al. | β | 2023 | β |
| Association between homocysteine and nonalcoholic fatty liver disease: Mendelian randomisation study. | Fu L et al. | β | 2023 | β |
| Association between human blood metabolome and the risk of breast cancer. | Wang Y et al. | β | 2023 | β |
| Association Between Human Blood Metabolome and the Risk of Psychiatric Disorders. | Jia Y et al. | β | 2023 | β |
| Association between Liver MRI Proton Density Fat Fraction and Liver Disease Risk. | Xia T et al. | β | 2023 | β |
| Association between myeloperoxidase and the risks of ischemic stroke, heart failure, and atrial fibrillation: A Mendelian randomization study. | Wang Y et al. | β | 2023 | β |
| Association Between Plasma Homocysteine Level and Mortality: A Mendelian Randomization Study. | Choi CK et al. | β | 2023 | β |
| Association Between Prekallikrein and Stroke: A Mendelian Randomization Study. | Wang Y et al. | β | 2023 | β |
| Association between psoriasis and lung cancer: two-sample Mendelian randomization analyses. | Wang X et al. | β | 2023 | β |
| Association Between Serum Bilirubin and Atrial Fibrillation: A Mendelian Randomization Study. | Kim SW et al. | β | 2023 | β |
| Association between serum uric acid and prostate cancer risk in East Asian populations: a Mendelian randomization study. | Deng Y et al. | β | 2023 | β |
| Association between total body bone mineral density and periodontitis: A Mendelian randomization study. | Alayash Z et al. | β | 2023 | β |
| Association of birth weight with cancer risk: a dose-response meta-analysis and Mendelian randomization study. | Chen C et al. | β | 2023 | β |
| Association of Hypertensive Disorders of Pregnancy With Future Cardiovascular Disease. | Rayes B et al. | β | 2023 | β |
| Association of leisure sedentary behavior and physical activity with the risk of nonalcoholic fatty liver disease: a two-sample Mendelian randomization study. | Zhang X et al. | β | 2023 | β |
| Associations between diet and incidence risk of lung cancer: A Mendelian randomization study. | Yan H et al. | β | 2023 | β |
| Associations between health behaviours, fertility and reproductive outcomes: triangulation of evidence in the Norwegian Mother, Father and Child Cohort Study (MoBa). | Wootton RE et al. | β | 2023 | β |
| Associations between modifiable risk factors and frailty: a Mendelian randomisation study. | Zhang N et al. | β | 2023 | β |
| Associations between polyunsaturated fatty acid concentrations and Parkinson's disease: A two-sample Mendelian randomization study. | Zhu X et al. | β | 2023 | β |
| Associations of 10 dietary habits with breast cancer: a Mendelian randomization study. | Wang X et al. | β | 2023 | β |
| Associations of alcohol and coffee with colorectal cancer risk in East Asian populations: a Mendelian randomization study. | Deng Y et al. | β | 2023 | β |
| Associations of cholecystectomy with the risk of colorectal cancer: a Mendelian randomization study. | Chen L et al. | β | 2023 | β |
| [Associations of circulating leptin levels with colorectal adenoma and colorectal cancer: a case-control and Mendelian randomization study]. | Zhao H et al. | β | 2023 | β |
| Asthma subtypes and risk of cardiovascular disease: A Mendelian randomization study. | Ng NYT et al. | β | 2023 | β |
| Atopic dermatitis and risk of 14 site-specific cancers: A Mendelian randomization study. | Liu Q et al. | β | 2023 | β |
| A two-sample mendelian randomization analysis excludes causal relationships between non-alcoholic fatty liver disease and kidney stones. | Li X et al. | β | 2023 | β |
| Birth weight, childhood obesity, adulthood obesity and body composition, and gastrointestinal diseases: a Mendelian randomization study. | Yuan S et al. | β | 2023 | β |
| BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep. | Rojo D et al. | β | 2023 | β |
| Cannabis Use and CKD: Epidemiological Associations and Mendelian Randomization. | Dellepiane S et al. | β | 2023 | β |
| Causal association between basal metabolic rate and risk of cardiovascular diseases: a univariable and multivariable Mendelian randomization study. | Li Y et al. | β | 2023 | β |
| Causal association between serum 25-Hydroxyvitamin D levels and cutaneous melanoma: a two-sample Mendelian randomization study. | Cai B et al. | β | 2023 | β |
| Causal association of genetically determined circulating vitamin D metabolites and calcium with multiple sclerosis in participants of European descent. | Zhang Y et al. | β | 2023 | β |
| Causal association of serum biomarkers with oral cavity and oropharyngeal cancer: a mendelian randomization study. | Liu W et al. | β | 2023 | β |
| Causal Associations Between Basal Metabolic Rate and COVID-19. | Baranova A et al. | β | 2023 | β |
| Causal associations between circulation Ξ²-carotene and cardiovascular disease: A Mendelian randomization study. | Liu S et al. | β | 2023 | β |
| Causal associations between hand grip strength and pulmonary function: a two-sample Mendelian randomization study. | Zhao X et al. | β | 2023 | β |
| Causal associations between obstructive sleep apnea and COVID-19: A bidirectional Mendelian randomization study. | Gao X et al. | β | 2023 | β |
| Causal associations between prodromal infection and neuromyelitis optica spectrum disorder: A Mendelian randomization study. | Wang L et al. | β | 2023 | β |
| Causal associations of SjΓΆgren's syndrome with cancers: a two-sample Mendelian randomization study. | Jia Y et al. | β | 2023 | β |
| Causal atlas between inflammatory bowel disease and mental disorders: a bi-directional 2-sample Mendelian randomization study. | Yang X et al. | β | 2023 | β |
| Causal effect of adiposity on the risk of 19 gastrointestinal diseases: a Mendelian randomization study. | Kim MS et al. | β | 2023 | β |
| Causal effect of beta-blockers on the risk of lung cancer: a Mendelian randomization study. | Lu Y et al. | β | 2023 | β |
| Causal Effect of Higher Glycated Hemoglobin (HbA1c) Levels on Knee Osteoarthritis Risk: A Mendelian Randomization Study. | Chen L et al. | β | 2023 | β |
| Causal Effect of the 25-Hydroxyvitamin D Concentration on Cerebral Small Vessel Disease: A Mendelian Randomization Study. | Lee KJ et al. | β | 2023 | β |
| Causal effects of genetically determined blood metabolites on multiple myeloma: a Mendelian randomization study. | Ren J et al. | β | 2023 | β |
| Causal effects of gut microbiome on autoimmune liver disease: a two-sample Mendelian randomization study. | Fu Y et al. | β | 2023 | β |
| Causal effects of gut microbiota on erectile dysfunction: a two-sample Mendelian randomization study. | Zhang Y et al. | β | 2023 | β |
| Causal effects of gut microbiota on sepsis: a two-sample Mendelian randomization study. | Chen JH et al. | β | 2023 | β |
| Causal effects of modifiable risk factors on kidney stones: a bidirectional mendelian randomization study. | Liu W et al. | β | 2023 | β |
| Causal effects of time-varying body size on selected autoimmune disorders: a life course Mendelian randomisation study. | Freuer D et al. | β | 2023 | β |
| Causal Inference of Central Nervous System-Regulated Hormones in COVID-19: A Bidirectional Two-Sample Mendelian Randomization Study. | Sun Y et al. | β | 2023 | β |
| Causality assessment of circulating Vitamin D level on venous thromboembolism: A Mendelian randomization study. | Zhang X et al. | β | 2023 | β |
| Causal link between thyroid function and schizophrenia: a two-sample Mendelian randomization study. | Freuer D et al. | β | 2023 | β |
| Causal links of Ξ±-thalassemia indices and cardiometabolic traits and diabetes: MR study. | Hsu LA et al. | β | 2023 | β |
| Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian randomization. | Hu G et al. | β | 2023 | β |
| Causal relationship between gastro-esophageal reflux disease and risk of lung cancer: insights from multivariable Mendelian randomization and mediation analysis. | Liu Y et al. | β | 2023 | β |
| Causal relationship between gastroesophageal reflux disease, Barrett's esophagus, and epilepsy: A bidirectional Mendelian randomization study. | Liu X et al. | β | 2023 | β |
| Causal relationship between Type 1 diabetes and osteoporosis and fracture occurrence: a two-sample Mendelian randomization analysis. | Tang Y et al. | β | 2023 | β |
| Causal Relationships between Air Pollutant Exposure and Bone Mineral Density and the Risk of Bone Fractures: Evidence from a Two-Stage Mendelian Randomization Analysis. | Hu X et al. | β | 2023 | β |
| Causal relationships between birth weight, childhood obesity and age at menarche: A two-sample Mendelian randomization analysis. | Wang L et al. | β | 2023 | β |
| Causal relationships of neonatal jaundice, direct bilirubin and indirect bilirubin with autism spectrum disorder: A two-sample Mendelian randomization analysis. | Chen LW et al. | β | 2023 | β |
| Celiac Disease Is a Risk Factor for Mature T and NK Cell Lymphoma: A Mendelian Randomization Study. | MartΓn-Masot R et al. | β | 2023 | β |
| Circulating Inflammatory Cytokines and Female Reproductive Diseases: A Mendelian Randomization Analysis. | Lin Y et al. | β | 2023 | β |
| Circulating levels of cytokines and risk of cardiovascular disease: a Mendelian randomization study. | Wei T et al. | β | 2023 | β |
| Circulating levels of micronutrients and risk of infections: a Mendelian randomization study. | Flatby HM et al. | β | 2023 | β |
| Constipation and cardiovascular disease: A two-sample Mendelian randomization analysis. | Dong Q et al. | β | 2023 | β |
| Contribution of Telomere Length to Systemic Sclerosis Onset: A Mendelian Randomization Study. | Rodriguez-Martin I et al. | β | 2023 | β |
| Cross-phenotype relationship between opioid use disorder and suicide attempts: new evidence from polygenic association and Mendelian randomization analyses. | Huang Y et al. | β | 2023 | β |
| Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country. | Boekstegers F et al. | β | 2023 | β |
| Dietary Factors and Endometrial Cancer Risk: A Mendelian Randomization Study. | Wang X et al. | β | 2023 | β |
| Diet-derived circulating antioxidants and risk of knee osteoarthritis, hip osteoarthritis and rheumatoid arthritis: a two-sample Mendelian randomization study. | Huang L et al. | β | 2023 | β |
| Dissecting Causal Associations of Diet-Derived Circulating Antioxidants with Six Major Mental Disorders: A Mendelian Randomization Study. | Zhao H et al. | β | 2023 | β |
| Dissecting shared genetic architecture between obesity and multiple sclerosis. | Zeng R et al. | β | 2023 | β |
| Dissecting the Association between Gut Microbiota and Brain Structure Change Rate: A Two-Sample Bidirectional Mendelian Randomization Study. | Huang H et al. | β | 2023 | β |
| Dissecting the mediating and moderating effects of depression on the associations between traits and coronary artery disease: A two-step Mendelian randomization and phenome-wide interaction study. | Zheng X et al. | β | 2023 | β |
| Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk. | Zhou X et al. | β | 2023 | β |
| Does inflammatory bowel disease promote kidney diseases: a mendelian randomization study with populations of European ancestry. | Lian X et al. | β | 2023 | β |
| Does proton pump inhibitors use increase risk of digestive tumors?: A 2-sample Mendelian randomization study. | Zhao R et al. | β | 2023 | β |
| Effect of bilirubin and Gilbert syndrome on health: cohort analysis of observational, genetic, and Mendelian randomisation associations. | Hamilton FW et al. | β | 2023 | β |
| Effects of 25-Hydroxyvitamin D Levels on Renal Function: A Bidirectional Mendelian Randomization Study. | Adi M et al. | β | 2023 | β |
| Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study. | Pan Y et al. | β | 2023 | β |
| Effects of gut microbiota on prostatic cancer: a two-sample Mendelian randomization study. | Xie Q et al. | β | 2023 | β |
| Endometriosis Increases the Risk of Stroke: A Mendelian Randomization Study. | Zheng M et al. | β | 2023 | β |
| Evaluating the Causal Association between Inflammatory Bowel Disease and Risk of Atherosclerotic Cardiovascular Disease: Univariable and Multivariable Mendelian Randomization Study. | Liu B et al. | β | 2023 | β |
| Evaluating the causality between skin tanning, radiated disorders, and basal cell carcinoma: a multivariable Mendelian randomization analysis. | Chen C et al. | β | 2023 | β |
| Evaluating the causal relationship between five modifiable factors and the risk of spinal stenosis: a multivariable Mendelian randomization analysis. | Wan B et al. | β | 2023 | β |
| Evaluating the effect of childhood sunburn on the risk of cutaneous melanoma through Mendelian randomization. | Zhong S et al. | β | 2023 | β |
| Evaluating the effect of metabolic traits on oral and oropharyngeal cancer risk using Mendelian randomization. | Gormley M et al. | β | 2023 | β |
| Evaluation for causal effects of socioeconomic traits on risk of female genital prolapse (FGP): a multivariable Mendelian randomization analysis. | Zhang W et al. | β | 2023 | β |
| Evidence of causality of low body mass index on risk of adolescent idiopathic scoliosis: a Mendelian randomization study. | Otomo N et al. | β | 2023 | β |
| Exploration of the causal effects of leukocyte telomere length and four gastrointestinal diseases: a two-sample bidirectional Mendelian randomization study. | Wang H et al. | β | 2023 | β |
| Exploring causal effects of smoking and alcohol related lifestyle factors on self-report tiredness: A Mendelian randomization study. | Li H et al. | β | 2023 | β |
| Exploring the Causality Between Body Mass Index and Sepsis: A Two-Sample Mendelian Randomization Study. | Wang J et al. | β | 2023 | β |
| Exploring the causality between educational attainment and gastroesophageal reflux disease: A Mendelian randomization study. | Chen G et al. | β | 2023 | β |
| Extra cup of tea intake associated with increased risk of Alzheimer's disease: Genetic insights from Mendelian randomization. | Sun Y et al. | β | 2023 | β |
| Four modifiable factors that mediate the effect of educational time on major depressive disorder risk: A network Mendelian randomization study. | Wan B et al. | β | 2023 | β |
| Gallbladder Cancer Risk and Indigenous South American Mapuche Ancestry: Instrumental Variable Analysis Using Ancestry-Informative Markers. | Zollner L et al. | β | 2023 | β |
| Genetically determined circulating resistin concentrations and risk of colorectal cancer: a two-sample Mendelian randomization study. | Pham TT et al. | β | 2023 | β |
| Genetically Determined Metabolites in Graves Disease: Insight From a Mendelian Randomization Study. | Tan Y et al. | β | 2023 | β |
| Genetically predicted 486 blood metabolites in relation to risk of colorectal cancer: A Mendelian randomization study. | Yun Z et al. | β | 2023 | β |
| Genetically predicted basal metabolic rate and venous thromboembolism risk: a Mendelian randomization study. | Huang J et al. | β | 2023 | β |
| Genetically predicted childhood body mass index and lung cancer susceptibility: A two-sample Mendelian randomization study. | Wu D et al. | β | 2023 | β |
| Genetically predicted levels of circulating cytokines and the risk of six immune skin diseases: a two-sample Mendelian randomization study. | Luo Q et al. | β | 2023 | β |
| Genetically predicted tobacco consumption and risk of intracranial aneurysm: a Mendelian randomization study. | Zeng C et al. | β | 2023 | β |
| Genetic association and causal inference between lung function and venous thromboembolism. | Zhang Q et al. | β | 2023 | β |
| Genetic associations of leisure sedentary behaviors and the risk of 15 site-specific cancers: A Mendelian randomization study. | Chen J et al. | β | 2023 | β |
| Genetic evidence for causal relationships between age at natural menopause and the risk of ageing-associated adverse health outcomes. | Lankester J et al. | β | 2023 | β |
| Genetic evidence for the causal linkage between telomere length and aortic aneurysm risk: A Mendelian randomisation study. | Zhang R et al. | β | 2023 | β |
| Genetic evidence strengthens the bidirectional connection between gut microbiota and periodontitis: insights from a two-sample Mendelian randomization study. | Ye X et al. | β | 2023 | β |
| Genetic Insights into Obesity and Brain: Combine Mendelian Randomization Study and Gene Expression Analysis. | Chen L et al. | β | 2023 | β |
| Genetic liability to multiple factors and uterine leiomyoma risk: a Mendelian randomization study. | Qu Y et al. | β | 2023 | β |
| Genetic Predisposition to a Higher Whole Body Water Mass May Increase the Risk of Atrial Fibrillation: A Mendelian Randomization Study. | Zhu Q et al. | β | 2023 | β |
| Genetic predisposition to white blood cells in relation to the risk of frailty. | Wu L et al. | β | 2023 | β |
| Genome-Wide Association and Two-Sample Mendelian Randomization Analyses of Plasma Ghrelin and Gastrointestinal Cancer Risk. | Larsson SC et al. | β | 2023 | β |
| Glycoprotein acetyls and depression: Testing for directionality and potential causality using longitudinal data and Mendelian randomization analyses. | Crick DCP et al. | β | 2023 | β |
| Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study. | Pettit RW et al. | β | 2023 | β |
| Identification of host gene-microbiome associations in colorectal cancer patients using mendelian randomization. | Xiang Y et al. | β | 2023 | β |
| Identifying effects of genetic obesity exposure on leukocyte telomere length using Mendelian randomization. | Wan B et al. | β | 2023 | β |
| Identifying Suitable Targets for Alzheimer's Disease and Other Eight Common Neurological Disorders Using the Human Plasma Proteome: A Mendelian Randomization Study. | Wei T et al. | β | 2023 | β |
| Impairment of kidney function and kidney cancer: A bidirectional Mendelian randomization study. | Lin Y et al. | β | 2023 | β |
| Inflammatory bowel disease and bladder cancer risk: based on a Mendelian randomization study. | Wang L et al. | β | 2023 | β |
| Inflammatory bowel disease and prostate cancer risk: a two-sample Mendelian randomization analysis. | Cheng W et al. | β | 2023 | β |
| Inflammatory bowel disease is causally related to irritable bowel syndrome: a bidirectional two-sample Mendelian randomization study. | Ke H et al. | β | 2023 | β |
| Insight into the causality between basal metabolic rate and endometrial and ovarian cancers: Analysis utilizing systematic Mendelian randomization and genetic association data from over 331,000 UK biobank participants. | Zhang H et al. | β | 2023 | β |
| Integrating genetics and metabolomics from multi-ethnic and multi-fluid data reveals putative mechanisms for age-related macular degeneration. | Han X et al. | β | 2023 | β |
| Integrating plasma proteomes with genome-wide association data for causal protein identification in multiple myeloma. | Wang Q et al. | β | 2023 | β |
| Integrative analysis of Mendelian randomization and gene expression profiles reveals a null causal relationship between adiponectin and diabetic retinopathy. | Zhang A et al. | β | 2023 | β |
| Intercellular adhesion molecule 4 and ischemic stroke: a two-sample Mendelian randomization study. | Sun L et al. | β | 2023 | β |
| Interleukin-17 and inflammatory bowel disease: a 2-sample Mendelian randomization study. | Cai Y et al. | β | 2023 | β |
| Interrogating Causal Effects of Body Composition and Puberty-Related Risk Factors on Adolescent Idiopathic Scoliosis: A Two-Sample Mendelian Randomization Study. | Ghanbari F et al. | β | 2023 | β |
| Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: a Mendelian randomization study. | Decina CS et al. | β | 2023 | β |
| Investigating the association between serum ADAM/ADAMTS levels and bone mineral density by mendelian randomization study. | Lv X et al. | β | 2023 | β |
| Investigating the Impact of Sun/UV Protection and Ease of Skin Tanning on the Risk of Pseudoexfoliation Glaucoma: A Mendelian Randomization Study. | Dai J et al. | β | 2023 | β |
| Investigation of the causal relationship between osteocalcin and dementia: A Mendelian randomization study. | Liu W et al. | β | 2023 | β |
| Ischemic Stroke and Cerebral Microbleeds: A Two-Sample Bidirectional Mendelian Randomization Study. | Liu R et al. | β | 2023 | β |
| Leisure sedentary behaviour increases the risk of venous thromboembolism: a Mendelian randomisation study. | Chen L et al. | β | 2023 | β |
| Leisure time sedentary behaviour and risks of breast, colorectal, and prostate cancer: A Mendelian randomization analysis | Papadimitriou N et al. | β | 2023 | β |
| Leukocyte telomere length and bipolar disorder risk: evidence from Mendelian randomization analysis. | Lu L et al. | β | 2023 | β |
| Leukocyte telomere length is associated with increased risk of endometriosis: a bidirectional two-sample Mendelian randomization study. | Bai C et al. | β | 2023 | β |
| Lipid-induced transcriptomic changes in blood link to lipid metabolism and allergic response. | Dekkers KF et al. | β | 2023 | β |
| Major depression disorder may causally associate with the increased atrial fibrillation risk: evidence from two-sample mendelian randomization analyses. | Wang L et al. | β | 2023 | β |
| Major depression disorder may causally associate with the increased breast cancer risk: Evidence from two-sample mendelian randomization analyses. | Ren Q et al. | β | 2023 | β |
| Major depressive disorder and chronic gastritis: A bidirectional two-sample Mendelian randomization study. | Li J et al. | β | 2023 | β |
| Mendelian Randomization Analyses of Chronic Immune-Mediated Diseases, Circulating Inflammatory Biomarkers, and Cytokines in Relation to Liver Cancer. | Yin Q et al. | β | 2023 | β |
| Mendelian randomization analyses suggest a causal role for circulating GIP and IL-1RA levels in homeostatic model assessment-derived measures of Ξ²-cell function and insulin sensitivity in Africans without type 2 diabetes. | Meeks KAC et al. | β | 2023 | β |
| Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis. | Lin Y et al. | β | 2023 | β |
| Mendelian randomization analysis to elucidate the causal relationship between small molecule metabolites and ovarian cancer risk. | Chang X et al. | β | 2023 | β |
| Mendelian randomization eradicates the causal relationship between educational attainment, household income, and oropharyngeal cancer. | Qi L et al. | β | 2023 | β |
| Mendelian randomization identifies age at menarche as an independent causal effect factor for gestational diabetes mellitus. | Lu L et al. | β | 2023 | β |
| Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes. | Lu F et al. | β | 2023 | β |
| Mendelian randomization investigation highlights different roles of selenium status in mental disorders. | Guo X et al. | β | 2023 | β |
| Mendelian randomization reveals no associations of genetically-predicted obstructive sleep apnea with the risk of type 2 diabetes, nonalcoholic fatty liver disease, and coronary heart disease. | Ding X et al. | β | 2023 | β |
| Mendelian randomization reveals no correlations between herpesvirus infection and idiopathic pulmonary fibrosis. | Yan H et al. | β | 2023 | β |
| Mendelian randomization study of gastroesophageal reflux disease and major depression. | Zheng X et al. | β | 2023 | β |
| Mendelian randomization study of maternal coffee consumption and its influence on birthweight, stillbirth, miscarriage, gestational age and pre-term birth. | Brito Nunes C et al. | β | 2023 | β |
| Metabolic drivers of dysglycemia in pregnancy: ethnic-specific GWAS of 146 metabolites and 1-sample Mendelian randomization analyses in a UK multi-ethnic birth cohort. | Fuller H et al. | β | 2023 | β |
| Micronutrients and risks of three main urologic cancers: A mendelian randomization study. | Lu Y et al. | β | 2023 | β |
| Mid-life leukocyte telomere length and dementia risk: An observational and mendelian randomization study of 435,046 UK Biobank participants. | Liu R et al. | β | 2023 | β |
| Modifiable risk factors of major depressive disorder: A Mendelian randomization study. | Zheng X et al. | β | 2023 | β |
| Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study. | Wan B et al. | β | 2023 | β |
| Multiomic approach and Mendelian randomization analysis identify causal associations between blood biomarkers and subcortical brain structure volumes. | Jain PR et al. | β | 2023 | β |
| Native American ancestry and breast cancer risk in Colombian and Mexican women: ruling out potential confounding through ancestry-informative markers. | Zollner L et al. | β | 2023 | β |
| No association between genetically predicted C-reactive protein levels and colorectal cancer survival in Korean: two-sample Mendelian randomization analysis. | Choi CK et al. | β | 2023 | β |
| No evident causal association between Helicobacter pylori infection and colorectal cancer: a bidirectional mendelian randomization study. | Luo F et al. | β | 2023 | β |
| Noncausal effects between tea intake and migraine risk: a Mendelian randomization study. | Jin C et al. | β | 2023 | β |
| Obesity and risk of gestational diabetes mellitus: A two-sample Mendelian randomization study. | Song X et al. | β | 2023 | β |
| Osteoarthritis and risk of type 2 diabetes: A two-sample Mendelian randomization analysis. | Xing X et al. | β | 2023 | β |
| Phenotypic but not genetically predicted heart rate variability associated with all-cause mortality. | Tegegne BS et al. | β | 2023 | β |
| Physical Activity, Sedentary Behavior, and Osteoarthritis: A Two-Sample Mendelian Randomization Analysis. | Wang Y et al. | β | 2023 | β |
| Plasma homocysteine levels and risk of congestive heart failure or cardiomyopathy: A Mendelian randomization study. | Wang X et al. | β | 2023 | β |
| Plasma proteins and onset of type 2 diabetes and diabetic complications: Proteome-wide Mendelian randomization and colocalization analyses. | Yuan S et al. | β | 2023 | β |
| Positive association between omega-3/6 polyunsaturated fatty acids and idiopathic normal pressure hydrocephalus: a mendelian randomization study. | Li J et al. | β | 2023 | β |
| Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer. | Nimptsch K et al. | β | 2023 | β |
| Protective effect of uridine on atrial fibrillation: a Mendelian randomisation study. | Xu X et al. | β | 2023 | β |
| Proteomic insights into the associations between obesity, lifestyle factors, and coronary artery disease. | Yang F et al. | β | 2023 | β |
| Relationship between genetically proxied vitamin D andΒ psoriasis risk: a Mendelian randomization study. | Bohmann P et al. | β | 2023 | β |
| Risk of second primary cancers after a diagnosis of first primary cancer: A pan-cancer analysis and Mendelian randomization study. | Ruan X et al. | β | 2023 | β |
| RNA alternative splicing impacts the risk for alcohol use disorder. | Li R et al. | β | 2023 | β |
| Selection of genetic instruments in Mendelian randomisation studies of sleep traits. | Paz V et al. | β | 2023 | β |
| Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study. | Papadimitriou N et al. | β | 2023 | β |
| Serum 25-Hydroxyvitamin D Levels and Youth-Onset Type 2 Diabetes: A Two-Sample Mendelian Randomization Study. | De La Barrera B et al. | β | 2023 | β |
| Serum uric acid and risk of diabetic neuropathy: a genetic correlation and mendelian randomization study. | Zhang Y et al. | β | 2023 | β |
| Serum vitamin D levels and Sjogren's syndrome: bi-directional Mendelian randomization analysis. | Zhao M et al. | β | 2023 | β |
| Severe mental illness and the risk of breast cancer: A two-sample, two-step multivariable Mendelian randomization study. | Cui Y et al. | β | 2023 | β |
| Sex hormone-binding globulin exerts sex-related causal effects on lower extremity varicose veins: evidence from gender-stratified Mendelian randomization. | Fan Q et al. | β | 2023 | β |
| Sex hormones in the risk of breast cancer: a two-sample Mendelian randomization study. | Ke B et al. | β | 2023 | β |
| Sexual behavior and cardiovascular diseases: univariable and multivariable Mendelian randomization. | Zhu K et al. | β | 2023 | β |
| Shared genetic loci and causal relations between schizophrenia and obsessive-compulsive disorder. | Chen Y et al. | β | 2023 | β |
| Shared Genetics and Comorbid Genes of Amyotrophic Lateral Sclerosis and Parkinson's Disease. | Tian Y et al. | β | 2023 | β |
| Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis. | Yuan S et al. | β | 2023 | β |
| ST2 and CSF-1 as potential druggable targets of inflammatory bowel diseases: Results from two-sample Mendelian randomization study. | Mi J et al. | β | 2023 | β |
| Systemic evaluation of the relationship between asthma and osteoarthritis: Evidence from a meta-analysis and Mendelian randomization study. | Nie Y et al. | β | 2023 | β |
| The association between basal metabolic rate and osteoarthritis: a Mendelian randomization study. | Zhou J et al. | β | 2023 | β |
| The association between epilepsy and COVID-19: analysis based on Mendelian randomization and FUMA. | You M et al. | β | 2023 | β |
| The association between gut microbiome and PCOS: evidence from meta-analysis and two-sample mendelian randomization. | Min Q et al. | β | 2023 | β |
| The association of alanine aminotransferase and diabetic microvascular complications: A Mendelian randomization study. | Bi Y et al. | β | 2023 | β |
| The association of psychological stress with metabolic syndrome and its components: cross-sectional and bidirectional two-sample Mendelian randomization analyses. | Li C et al. | β | 2023 | β |
| The association of vitamin D and digestive system cancers: a comprehensive Mendelian randomization study. | Chen B et al. | β | 2023 | β |
| The causal association between polycystic ovary syndrome and susceptibility and severity of COVID-19: a bidirectional Mendelian randomization study using genetic data. | Si Y et al. | β | 2023 | β |
| The causal association between smoking, alcohol consumption and risk of upper urinary calculi: insights from a Mendelian randomization study. | Wang L et al. | β | 2023 | β |
| The causal effect of life course adiposity on periodontitis: A Mendelian randomization study. | Li W et al. | β | 2023 | β |
| The causal effect of physical activity intensity on COVID-19 susceptibility, hospitalization, and severity: Evidence from a mendelian randomization study. | Zhang X et al. | β | 2023 | β |
| The causal effect of two occupational factors on osteoarthritis and rheumatoid arthritis: a Mendelian randomization study. | Huang J | β | 2023 | β |
| The causal effects of genetically determined human blood metabolites on the risk of atrial fibrillation. | Cheng T et al. | β | 2023 | β |
| The causal effects of lipid traits on kidney function in Africans: bidirectional and multivariable Mendelian-randomization study. | Kintu C et al. | β | 2023 | β |
| The genetic associations of COVID-19 on genitourinary symptoms. | Chang Z et al. | β | 2023 | β |
| The impact of immunoglobulin G N-glycosylation level on COVID-19 outcome: evidence from a Mendelian randomization study. | Long F et al. | β | 2023 | β |
| The relationship between major depression and delirium: A two-sample Mendelian randomization analysis. | Li J et al. | β | 2023 | β |
| The relationship between the serum lipid profile and hepatocellular carcinoma in east Asian population: A mendelian randomization study. | Pan GQ et al. | β | 2023 | β |
| The serum lipid profiles in immune thrombocytopenia: Mendelian randomization analysis and a retrospective study. | Xu P et al. | β | 2023 | β |
| Trans-ethnic Mendelian randomization study of systemic lupus erythematosus and common female hormone-dependent malignancies. | Zhu T et al. | β | 2023 | β |
| Triangulating evidence for the causal impact of single-intervention zinc supplement on glycaemic control for type 2 diabetes: systematic review and meta-analysis of randomised controlled trial and two-sample Mendelian randomisation. | Wang Z et al. | β | 2023 | β |
| Two-sample mendelian randomization reveals a causal association between membranous nephropathy and lung cancer. | Yang K et al. | β | 2023 | β |
| Uncovering a causal connection between the <i>Lachnoclostridium</i> genus in fecal microbiota and non-alcoholic fatty liver disease: a two-sample Mendelian randomization analysis. | Dai W et al. | β | 2023 | β |
| Univariable and multivariable Mendelian randomization investigating the effects of telomere length on the risk of adverse pregnancy outcomes. | Han X et al. | β | 2023 | β |
| Unravelling the genetic causality of immunoglobulin G N-glycans in ischemic stroke. | Wang B et al. | β | 2023 | β |
| Using genetic association data to guide drug discovery and development: Review of methods and applications. | Burgess S et al. | β | 2023 | β |
| Varicella-zoster virus infection and primary membranous nephropathy: a Mendelian randomization study. | Li L et al. | β | 2023 | β |
| Visceral adipose tissue and osteoarthritis, a two-sample Mendelian randomized study. | Zhang Y et al. | β | 2023 | β |
| Vitamin D and suicidality: a Chinese early adolescent cohort and Mendelian randomization study. | Yuan M et al. | β | 2023 | β |
| A Bidirectional Mendelian Randomization Study of Selenium Levels and Ischemic Stroke. | Fang H et al. | β | 2022 | β |
| Absence of causal association between Vitamin D and bone mineral density across the lifespan: a Mendelian randomization study. | Tang Y et al. | β | 2022 | β |
| ADHD and its neurocognitive substrates: A two sample Mendelian randomization study. | Ahn K et al. | β | 2022 | β |
| Adiponectin and the risk of gastrointestinal cancers in East Asians: Mendelian randomization analysis. | Jiang H et al. | β | 2022 | β |
| Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study. | Yuan S et al. | β | 2022 | β |
| Alcohol consumption, blood DNA methylation and breast cancer: a Mendelian randomisation study. | Zhou X et al. | β | 2022 | β |
| A Mendelian randomization study investigating the causal role of inflammation on Parkinson's disease. | Bottigliengo D et al. | β | 2022 | β |
| A Mendelian randomization study of the effect of tea intake on breast cancer. | Deng Y et al. | β | 2022 | β |
| A Mendelian Randomization Study of the Effect of Tea Intake on Type 2 Diabetes. | Zhang Y et al. | β | 2022 | β |
| A Mendelian randomization study on the effect of 25-hydroxyvitamin D levels on periodontitis. | Baumeister SE et al. | β | 2022 | β |
| A Mild Causal Relationship Between Tea Consumption and Obesity in General Population: A Two-Sample Mendelian Randomization Study. | Li C et al. | β | 2022 | β |
| Assessing Causal Associations of Atopic Dermatitis With Heart Failure and Other Cardiovascular Outcomes: A Mendelian Randomization Study. | Chen H et al. | β | 2022 | β |
| Assessing causal relationships between sarcopenia and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study. | Zhao ZH et al. | β | 2022 | β |
| Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study. | Zhuo C et al. | β | 2022 | β |
| Assessment of the causal association between celiac disease and cardiovascular diseases. | Huang J | β | 2022 | β |
| Assessment of the genetic and clinical determinants of hip fracture risk: Genome-wide association and Mendelian randomization study. | Nethander M et al. | β | 2022 | β |
| Association between circulating vitamin E and ten common cancers: evidence from large-scale Mendelian randomization analysis and a longitudinal cohort study. | Xin J et al. | β | 2022 | β |
| Association Between C-Reactive Protein and Risk of Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study. | Zhu Y et al. | β | 2022 | β |
| Association between Human Blood Metabolome and the Risk of Alzheimer's Disease. | Sun L et al. | β | 2022 | β |
| Association between inflammatory bowel disease and Parkinson's disease: A Mendelian randomization study. | Freuer D et al. | β | 2022 | β |
| Association between plasma proteome and childhood neurodevelopmental disorders: A two-sample Mendelian randomization analysis. | Yang J et al. | β | 2022 | β |
| Association of Atopic Dermatitis with Depression and Suicide: A Two-Sample Mendelian Randomization Study. | Qi HJ et al. | β | 2022 | β |
| Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis. | Murphy N et al. | β | 2022 | β |
| Associations between serum urate and telomere length and inflammation markers: Evidence from UK Biobank cohort. | Lv Z et al. | β | 2022 | β |
| Associations between six dietary habits and risk of hepatocellular carcinoma: A Mendelian randomization study. | Deng Y et al. | β | 2022 | β |
| Associations of genetically proxied inhibition of HMG-CoA reductase, NPC1L1, and PCSK9 with breast cancer and prostate cancer. | Sun L et al. | β | 2022 | β |
| Basal metabolic rate and risk of multiple sclerosis: a Mendelian randomization study. | Liu C et al. | β | 2022 | β |
| Beef intake and risk of rheumatoid arthritis: Insights from a cross-sectional study and two-sample Mendelian randomization. | Chen W et al. | β | 2022 | β |
| Bidirectional Association between Major Depressive Disorder and Gastroesophageal Reflux Disease: Mendelian Randomization Study. | Miao Y et al. | β | 2022 | β |
| Blood Lipids and the Risk of Colorectal Cancer: Mendelian Randomization Analyses in the Japanese Consortium of Genetic Epidemiology Studies. | Iwagami M et al. | β | 2022 | β |
| Body mass index and healthcare costs: using genetic variants from the HUNT study as instrumental variables. | Edwards CH et al. | β | 2022 | β |
| Body Mass Index and Risk of Diabetic Nephropathy: A Mendelian Randomization Study. | Lu J et al. | β | 2022 | β |
| Cardiac Troponin I and Risk of Stroke: A Mendelian Randomization Study. | Chen H et al. | β | 2022 | β |
| Cardiovascular Risk Factors and MRI Markers of Cerebral Small Vessel Disease: A Mendelian Randomization Study. | Taylor-Bateman V et al. | β | 2022 | β |
| Causal Association between Chronic Kidney Disease and Risk of 19 Site-Specific Cancers: A Mendelian Randomization Study. | Tang L et al. | β | 2022 | β |
| Causal association between inflammatory bowel disease and IgA nephropathy: A bidirectional two-sample Mendelian randomization study. | Xiao M et al. | β | 2022 | β |
| Causal Association between Whole-Body Water Mass and Sleep Apnea: A Mendelian Randomization Study. | Zhou T et al. | β | 2022 | β |
| Causal association of diet-derived circulating antioxidants with the risk of rheumatoid arthritis: A Mendelian randomization study. | Zhou X et al. | β | 2022 | β |
| Causal Associations Between Circulating Adipokines and Cardiovascular Disease: A Mendelian Randomization Study. | Chen D et al. | β | 2022 | β |
| Causal associations between dietary antioxidant vitamin intake and lung cancer: A Mendelian randomization study. | Zhao H et al. | β | 2022 | β |
| Causal Associations between Vitamin D Levels and Psoriasis, Atopic Dermatitis, and Vitiligo: A Bidirectional Two-Sample Mendelian Randomization Analysis. | Ren Y et al. | β | 2022 | β |
| Causal Associations of Circulating Lipids with Osteoarthritis: A Bidirectional Mendelian Randomization Study. | Meng H et al. | β | 2022 | β |
| Causal associations of iron status and back pain risk: A Mendelian randomization study. | Tang Y et al. | β | 2022 | β |
| Causal Associations of Obesity With Achilles Tendinopathy: A Two-Sample Mendelian Randomization Study. | He L et al. | β | 2022 | β |
| Causal Effect of Age at Menarche on the Risk for Depression: Results From a Two-Sample Multivariable Mendelian Randomization Study. | Hirtz R et al. | β | 2022 | β |
| Causal effects of B vitamins and homocysteine on obesity and musculoskeletal diseases: A Mendelian randomization study. | Fu L et al. | β | 2022 | β |
| Causality of telomere length associated with calcific aortic valvular stenosis: A Mendelian randomization study. | Wang J et al. | β | 2022 | β |
| Causal relationship between genetically predicted depression and cancer risk: a two-sample bi-directional mendelian randomization. | Zhu GL et al. | β | 2022 | β |
| Causal relationship between gut microbiota and serum vitamin D: evidence from genetic correlation and Mendelian randomization study. | Yang X et al. | β | 2022 | β |
| Causal relationship between obesity, lifestyle factors and risk of benign prostatic hyperplasia: a univariable and multivariable Mendelian randomization study. | Wang YB et al. | β | 2022 | β |
| Causal relationships between blood calcium, iron, magnesium, zinc, selenium, phosphorus, copper, and lead levels and multisystem disease outcomes in over 400,000 Caucasian participants. | Huang L et al. | β | 2022 | β |
| Circulating Concentrations of Nutrition-Related Factors Are Not Causally Associated With Atrial Fibrillation: A Mendelian Randomization Study. | Huang J | β | 2022 | β |
| Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis. | Bouras E et al. | β | 2022 | β |
| Circulating Insulin-Like Growth FactorΒ 1 Levels and Migraine Risk: A Mendelian Randomization Study. | Abuduxukuer R et al. | β | 2022 | β |
| Circulating Vitamin D Concentrations and Risk of Atrial Fibrillation: A Mendelian Randomization Study Using Non-deficient Range Summary Statistics. | Zhang N et al. | β | 2022 | β |
| Comparing the Relationships of Genetically Proxied PCSK9 Inhibition With Mood Disorders, Cognition, and Dementia Between Men and Women: A Drug-Target Mendelian Randomization Study. | Bell AS et al. | β | 2022 | β |
| Considering strategies for SNP selection in genetic and polygenic risk scores. | St-Pierre J et al. | β | 2022 | β |
| Contribution of metabolic risk factors and lifestyle behaviors to cardiovascular disease: A mendelian randomization study. | Jia Y et al. | β | 2022 | β |
| COVID-19 and risk of neurodegenerative disorders: A Mendelian randomization study. | Li C et al. | β | 2022 | β |
| COVID-19 and the risk of Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis. | Zhang H et al. | β | 2022 | β |
| Depression and Inflammatory Bowel Disease: A Bidirectional Two-sample Mendelian Randomization Study. | Luo J et al. | β | 2022 | β |
| Diet-Derived Circulating Antioxidants and Risk of Digestive System Tumors: A Mendelian Randomization Study. | Yin L et al. | β | 2022 | β |
| Diet, Lifestyle Behaviours and Other Risk Factors Associated With TypeΒ 2 Diabetes Beyond Body Mass Index: A Mendelian Randomization Study. | Jia Y et al. | β | 2022 | β |
| Dissecting causal relationships between nonalcoholic fatty liver disease proxied by chronically elevated alanine transaminase levels and 34 extrahepatic diseases. | Liu Z et al. | β | 2022 | β |
| Dissecting the association between psychiatric disorders and neurological proteins: a genetic correlation and two-sample bidirectional Mendelian randomization study. | Huang H et al. | β | 2022 | β |
| Does smoking protect against developing osteoarthritis? Evidence from a genetically informed perspective. | Ni J et al. | β | 2022 | β |
| Educational attainment and endometrial cancer: A Mendelian randomization study. | Wang Q et al. | β | 2022 | β |
| Educational attainment could be a protective factor against obstructive sleep apnea: a study based on Mendelian randomization. | Song L et al. | β | 2022 | β |
| Effects of Selenium on Chronic Kidney Disease: A Mendelian Randomization Study. | Fu S et al. | β | 2022 | β |
| Effects of ulcerative colitis and Crohn's disease on neurodegenerative diseases: A Mendelian randomization study. | Li H et al. | β | 2022 | β |
| Endogenous DHEAS Is Causally Linked With Lumbar Spine Bone Mineral Density and Forearm Fractures in Women. | Quester J et al. | β | 2022 | β |
| Estimation of the bidirectional relationship between schizophrenia and inflammatory bowel disease using the mendelian randomization approach. | Qian L et al. | β | 2022 | β |
| Examination on the risk factors of cholangiocarcinoma: A Mendelian randomization study. | Chen L et al. | β | 2022 | β |
| Exploring the association between birthweight and breast cancer using summary statistics from a perspective of genetic correlation, mediation, and causality. | Zhang M et al. | β | 2022 | β |
| Exploring the causal effect of maternal pregnancy adiposity on offspring adiposity: Mendelian randomisation using polygenic risk scores. | Bond TA et al. | β | 2022 | β |
| Exploring the causality between ankylosing spondylitis and atrial fibrillation: A two-sample Mendelian randomization study. | Chen S et al. | β | 2022 | β |
| Family Socioeconomic Position and Lung Cancer Risk: A Meta-Analysis and a Mendelian Randomization Study. | Zou X et al. | β | 2022 | β |
| Fibrinogen in Alzheimer's Disease, Parkinson's Disease and Lewy Body Dementia: A Mendelian Randomization Study. | Zhang H et al. | β | 2022 | β |
| Frailty index and risk of cardiovascular diseases: a mendelian randomization study. | Li J et al. | β | 2022 | β |
| Genetically Predicted Circulating Concentrations of Micronutrients and COVID-19 Susceptibility and Severity: A Mendelian Randomization Study. | Daniel N et al. | β | 2022 | β |
| Genetically predicted cortisol levels and risk of venous thromboembolism. | Allara E et al. | β | 2022 | β |
| Genetically predicted higher educational attainment decreases the risk of stroke: a multivariable Mendelian randomization study. | Zhang W et al. | β | 2022 | β |
| Genetically predicted iron status was associated with the risk of prostate cancer. | Ying J et al. | β | 2022 | β |
| Genetic effects of iron levels on liver injury and risk of liver diseases: A two-sample Mendelian randomization analysis. | Wang K et al. | β | 2022 | β |
| Genetic estimation of correlations and causalities between multifaceted modifiable factors and gastro-oesophageal reflux disease. | Sun Y et al. | β | 2022 | β |
| Genetic evidence suggests that depression increases the risk of erectile dysfunction: A Mendelian randomization study. | Ma K et al. | β | 2022 | β |
| Genetic liability to obesity and peptic ulcer disease: a Mendelian randomization study. | Li Z et al. | β | 2022 | β |
| Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans. | Yang W et al. | β | 2022 | β |
| Health effects of high serum calcium levels: Updated phenome-wide Mendelian randomisation investigation and review of Mendelian randomisation studies. | Yuan S et al. | β | 2022 | β |
| High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study. | Plotnikov D et al. | β | 2022 | β |
| Homocysteine, folate, and nonalcoholic fatty liver disease: a systematic review with meta-analysis and Mendelian randomization investigation. | Yuan S et al. | β | 2022 | β |
| Hyperhomocysteinemia and intracranial aneurysm: A mendelian randomization study. | Ma C et al. | β | 2022 | β |
| Hypothyroidism has a protective causal association with hepatocellular carcinoma: A two-sample Mendelian randomization study. | Lu L et al. | β | 2022 | β |
| Inferring causal effects of homocysteine and B-vitamin concentrations on bone mineral density and fractures: Mendelian randomization analyses. | Fu L et al. | β | 2022 | β |
| Insomnia, sleep duration, and risk of anxiety: A two-sample Mendelian randomization study. | Zhou F et al. | β | 2022 | β |
| Interleukin-6 Receptor Blockade can Increase the Risk of Nonalcoholic Fatty Liver Disease: Indications From Mendelian Randomization. | Li S et al. | β | 2022 | β |
| Investigating Casual Associations Among Gut Microbiota, Metabolites, and Neurodegenerative Diseases: A Mendelian Randomization Study. | Ning J et al. | β | 2022 | β |
| Investigating Causal Associations of Circulating Micronutrients Concentrations with the Risk of Lung Cancer: A Mendelian Randomization Study. | Yan H et al. | β | 2022 | β |
| Investigating Causal Relations between Genetic-Related Intermediate Endophenotype and Risk of Chronic Prostatitis: Mendelian Randomization Study. | Zhang S et al. | β | 2022 | β |
| Investigating the association of atopic dermatitis with ischemic stroke and coronary heart disease: A mendelian randomization study. | Huang J et al. | β | 2022 | β |
| Investigating the potential impact of PCSK9-inhibitors on mood disorders using eQTL-based Mendelian randomization. | Aman A et al. | β | 2022 | β |
| Lifestyle and metabolic factors for nonalcoholic fatty liver disease: Mendelian randomization study. | Yuan S et al. | β | 2022 | β |
| Linear and nonlinear analyses of the association between low-density lipoprotein cholesterol and diabetes: The spurious U-curve in observational study. | Ma Y et al. | β | 2022 | β |
| Low vitamin D concentrations and BMI are causal factors for primary biliary cholangitis: A mendelian randomization study. | Xu H et al. | β | 2022 | β |
| Maternal Hypertension Increases Risk of Preeclampsia and Low Fetal Birthweight: Genetic Evidence From a Mendelian Randomization Study. | Ardissino M et al. | β | 2022 | β |
| Mendelian randomization. | Sanderson E et al. | β | 2022 | β |
| Mendelian randomization analysis of the causal association of bone mineral density and fracture with multiple sclerosis. | Yao Y et al. | β | 2022 | β |
| Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19. | Li J et al. | β | 2022 | β |
| Mendelian Randomization: Concepts and Scope. | Richmond RC et al. | β | 2022 | β |
| Mendelian randomization highlights the causal association of obesity with periodontal diseases. | Dong J et al. | β | 2022 | β |
| Mendelian randomization study indicates lack of causal associations between iron status and lung cancer. | Qin H et al. | β | 2022 | β |
| Mendelian randomization study of circulating lipids and biliary tract cancer among East Asians. | Wang J et al. | β | 2022 | β |
| Mendelian randomization study of the genetic interaction between psoriasis and celiac disease. | Li L et al. | β | 2022 | β |
| Mendelian randomization study supports the causal association between serum cystatin C and risk of diabetic nephropathy. | Feng B et al. | β | 2022 | β |
| Mendelian randomization supports the causal role of fasting glucose on periodontitis. | Wang Y et al. | β | 2022 | β |
| Multiple Sclerosis and the Risk of Cardiovascular Diseases: A Mendelian Randomization Study. | Yang F et al. | β | 2022 | β |
| No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study. | Nolde M et al. | β | 2022 | β |
| No Causal Association Between Coffee Consumption and Risk of Migraine: A Mendelian Randomization Study. | Chen H et al. | β | 2022 | β |
| No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis. | Yin KJ et al. | β | 2022 | β |
| Nonalcoholic fatty liver disease and cardiovascular diseases: A Mendelian randomization study. | Peng H et al. | β | 2022 | β |
| Obesity and risk of female reproductive conditions: A Mendelian randomisation study. | Venkatesh SS et al. | β | 2022 | β |
| Obstructive sleep apnea and the risk of Alzheimer's disease and Parkinson disease: A Mendelian randomization study OSA, Alzheimer's disease and Parkinson disease. | Li J et al. | β | 2022 | β |
| Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study. | Dixon-Suen SC et al. | β | 2022 | β |
| Plasma Circulating Vitamin C Levels and Risk of Endometrial Cancer: A Bi-Directional Mendelian Randomization Analysis. | Peng H et al. | β | 2022 | β |
| Plasma Phospholipid Fatty Acids and Risk of Venous Thromboembolism: Mendelian Randomization Investigation. | Yuan S et al. | β | 2022 | β |
| Predicted leukocyte telomere length and risk of germ cell tumours. | Cigan SS et al. | β | 2022 | β |
| Protective Effects of Circulating TIMP3 on Coronary Artery Disease and Myocardial Infarction: A Mendelian Randomization Study. | Chen H et al. | β | 2022 | β |
| Relationship between periodontitis and psoriasis: A two-sample Mendelian randomization study. | Baurecht H et al. | β | 2022 | β |
| Rheumatoid arthritis and risk of site-specific cancers: Mendelian randomization study in European and East Asian populations. | Yuan S et al. | β | 2022 | β |
| Roles of 21 Genera of Human Gut Microbiota in Barrett's Esophagus Risk: A Mendelian Randomization Study. | Yang Z et al. | β | 2022 | β |
| Self-reported daytime napping, daytime sleepiness, and other sleep phenotypes in the development of cardiometabolic diseases: a Mendelian randomization study. | Jia Y et al. | β | 2022 | β |
| Serum lipoprotein (a) associates with the risk of renal function damage in the CHCN-BTH Study: Cross-sectional and Mendelian randomization analyses. | Xie Y et al. | β | 2022 | β |
| Serum urate and heart failure: a bidirectional Mendelian randomization study. | Yang F et al. | β | 2022 | β |
| Sex-specific effect of serum urate levels on coronary heart disease and myocardial infarction prevention: A Mendelian randomization study. | Yang F et al. | β | 2022 | β |
| Shared Genetic Basis and Causal Relationship Between Television Watching, Breakfast Skipping and Type 2 Diabetes: Evidence From a Comprehensive Genetic Analysis. | Chen D et al. | β | 2022 | β |
| Shared genetic links between frontotemporal dementia and psychiatric disorders. | Li C et al. | β | 2022 | β |
| Sleep Disordered Breathing, Obesity and Atrial Fibrillation: A Mendelian Randomisation Study. | Ardissino M et al. | β | 2022 | β |
| Socioeconomic status, individual behaviors and risk for mental disorders: A Mendelian randomization study. | Cai J et al. | β | 2022 | β |
| Statistical power of transcriptome-wide association studies. | He R et al. | β | 2022 | β |
| Systematic review of Mendelian randomization studies on Parkinson's disease. | Kappen S et al. | β | 2022 | β |
| Systemic lupus erythematosus and the risk of cardiovascular diseases: A two-sample Mendelian randomization study. | Huang S et al. | β | 2022 | β |
| Target Discovery for Drug Development Using Mendelian Randomization. | Evans DS | β | 2022 | β |
| Telomere Length and Hearing Loss: A Two-Sample Mendelian Randomization. | Liu Y et al. | β | 2022 | β |
| The association between circulating docosahexaenoic acid and lung cancer: A Mendelian randomization study. | Zhao H et al. | β | 2022 | β |
| The association between mitochondrial DNA abundance and stroke: A combination of multivariable-adjusted survival and Mendelian randomization analyses. | Martens LG et al. | β | 2022 | β |
| The association of arterial stiffness index with cerebrovascular and cardiometabolic disease: A Mendelian randomization study. | Liu W et al. | β | 2022 | β |
| The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study. | Shi X et al. | β | 2022 | β |
| The causal association between iron status and the risk of autism: A Mendelian randomization study. | Chen L et al. | β | 2022 | β |
| The Effect of Body Fat Distribution on Systemic Sclerosis. | Villanueva-Martin G et al. | β | 2022 | β |
| The Effect of Circulating Zinc, Selenium, Copper and Vitamin K<sub>1</sub> on COVID-19 Outcomes: A Mendelian Randomization Study. | Sobczyk MK et al. | β | 2022 | β |
| The role of smoking and alcohol in mediating the effect of gastroesophageal reflux disease on lung cancer: A Mendelian randomization study. | Yang J et al. | β | 2022 | β |
| Type 2 Diabetes, Fasting Glucose, Hemoglobin A1c Levels and Risk of Primary Open-Angle Glaucoma: A Mendelian Randomization Study. | Hu Z et al. | β | 2022 | β |
| Visceral Adiposity and Risk of Stroke: A Mendelian Randomization Study. | Xu R et al. | β | 2022 | β |
| Vitamin D and Multiple Health Outcomes: An Umbrella Review of Observational Studies, Randomized Controlled Trials, and Mendelian Randomization Studies. | Liu D et al. | β | 2022 | β |
| Causal Association Between Periodontitis and Type 2 Diabetes: A Bidirectional Two-Sample Mendelian Randomization Analysis. | Wang YB et al. | β | 2021 | β |
| Educational Attainment and Ischemic Stroke: A Mendelian Randomization Study. | Gao L et al. | β | 2021 | β |
| Non-Causal Effects of Asthma on COVID-19 Susceptibility and Severity. | Qiu LJ et al. | β | 2021 | β |