Gene-environment interactions in psychiatry: joining forces with neuroscience.
paper
Cited
Public
Unavailable
- Authors
- Caspi, Avshalom; Moffitt, Terrie E
- Year
- 2006
- Journal
- Nature reviews. Neuroscience
- PMID
- 16791147
- DOI
- 10.1038/nrn1925
Gene-environment interaction research in psychiatry is new, and is a natural ally of neuroscience. Mental disorders have known environmental causes, but there is heterogeneity in the response to each causal factor, which gene-environment findings attribute to genetic differences at the DNA sequence level. Such findings come from epidemiology, an ideal branch of science for showing that a gene-environment interactions exist in nature and affect a significant fraction of disease cases. The complementary discipline of epidemiology, experimental neuroscience, fuels gene-environment hypotheses and investigates underlying neural mechanisms. This article discusses opportunities and challenges in the collaboration between psychiatry, epidemiology and neuroscience in studying gene-environment interactions.
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