Localizing epileptic seizure onsets with Granger causality.
- Authors
- Adhikari, Bhim M; Epstein, Charles M; Dhamala, Mukesh
- Year
- 2013
- Journal
- Physical review. E, Statistical, nonlinear, and soft matter physics
- PMID
- 24125204
- DOI
- 10.1103/PhysRevE.88.030701
Accurate localization of the epileptic seizure onset zones (SOZs) is crucial for successful surgery, which usually depends on the information obtained from intracranial electroencephalography (IEEG) recordings. The visual criteria and univariate methods of analyzing IEEG recordings have not always produced clarity on the SOZs for resection and ultimate seizure freedom for patients. Here, to contribute to improving the localization of the SOZs and to understanding the mechanism of seizure propagation over the brain, we applied spectral interdependency methods to IEEG time series recorded from patients during seizures. We found that the high-frequency (>80 Hz) Granger causality (GC) occurs before the onset of any visible ictal activity and causal relationships involve the recording electrodes where clinically identifiable seizures later develop. These results suggest that high-frequency oscillatory network activities precede and underlie epileptic seizures, and that GC spectral measures derived from IEEG can assist in precise delineation of seizure onset times and SOZs.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| AI-Driven Electrographic Seizure Classification and Seizure Onset Detection Using Image- and Time-Series-Based Approaches. | Afzal MF et al. | — | 2026 | → |
| Explosive transition in adaptive Stuart-Landau oscillators with higher-order interactions. | Verma UK | — | 2025 | → |
| Lag-mediated control of explosive synchronization transitions in adaptive multilayer networks with higher-order interactions. | Ghosh R et al. | — | 2025 | → |
| Noninvasive Seizure Onset Zone Localization Using Janashia-Lagvilava Algorithm-Based Spectral Factorization in Granger Causality. | Kasradze S et al. | — | 2025 | → |
| A Stable EEG Epilepsy Network Spans From Infraslow to Ripple and From Interictal to Ictus. | Ghimire S et al. | — | 2024 | → |
| Explosive transitions in coupled Lorenz oscillators. | Muthanna YA et al. | — | 2024 | → |
| Seizure onset zone (SOZ) identification using effective brain connectivity of epileptogenic networks. | Balaji SS et al. | — | 2024 | → |
| Tiered synchronization in Kuramoto oscillators with adaptive higher-order interactions. | Rajwani P et al. | — | 2023 | → |
| Catalytic feed-forward explosive synchronization in multilayer networks. | Rathore V et al. | — | 2021 | → |
| Inhibition-induced explosive synchronization in multiplex networks. | Jalan S et al. | — | 2019 | → |
| Synchronization transition in Sakaguchi-Kuramoto model on complex networks with partial degree-frequency correlation. | Kundu P et al. | — | 2019 | → |
| Exact explosive synchronization transitions in Kuramoto oscillators with time-delayed coupling. | Wu H et al. | — | 2018 | → |
| A small change in neuronal network topology can induce explosive synchronization transition and activity propagation in the entire network. | Wang Z et al. | — | 2017 | → |
| Reliability of EEG Interactions Differs between Measures and Is Specific for Neurological Diseases. | Höller Y et al. | — | 2017 | → |
| When two wrongs make a right: synchronized neuronal bursting from combined electrical and inhibitory coupling. | Reimbayev R et al. | — | 2017 | → |
| Noninvasive Electromagnetic Source Imaging and Granger Causality Analysis: An Electrophysiological Connectome (eConnectome) Approach. | Sohrabpour A et al. | — | 2016 | → |
| The salience network dynamics in perceptual decision-making. | Chand GB et al. | — | 2016 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Dynamic directed interictal connectivity in left and right temporal lobe epilepsy. | Coito A et al. | — | 2015 | → |
| Explosive synchronization in adaptive and multilayer networks. | Zhang X et al. | — | 2015 | → |
| Self-organized correlations lead to explosive synchronization. | Chen Y et al. | — | 2015 | → |
| Explosive synchronization as a process of explosive percolation in dynamical phase space. | Zhang X et al. | — | 2014 | → |
| Functional brain connectivity from EEG in epilepsy: seizure prediction and epileptogenic focus localization. | van Mierlo P et al. | — | 2014 | → |
| Ictal propagation of high frequency activity is recapitulated in interictal recordings: effective connectivity of epileptogenic networks recorded with intracranial EEG. | Korzeniewska A et al. | — | 2014 | → |