Neurobiology of the Caenorhabditis elegans genome.
paper
Cited
Public
Unavailable
- Authors
- Bargmann, C I
- Year
- 1998
- Journal
- Science (New York, N.Y.)
- PMID
- 9851919
- DOI
- 10.1126/science.282.5396.2028
Neurotransmitter receptors, neurotransmitter synthesis and release pathways, and heterotrimeric GTP-binding protein (G protein)-coupled second messenger pathways are highly conserved between Caenorhabditis elegans and mammals, but gap junctions and chemosensory receptors have independent origins in vertebrates and nematodes. Most ion channels are similar to vertebrate channels but there are no predicted voltage-activated sodium channels. The C. elegans genome encodes at least 80 potassium channels, 90 neurotransmitter-gated ion channels, 50 peptide receptors, and up to 1000 orphan receptors that may be chemoreceptors. For many gene families, C. elegans has both conventional members and divergent outliers with weak homology to known genes; these outliers may provide insights into previously unknown functions of conserved protein families.
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| Progress in methodology. Improved reporter gene assays used to identify ligands acting on orphan seven-transmembrane receptors. | Kotarsky K et al. | β | 2003 | β |
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| Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. | Blackhall WJ et al. | β | 2003 | β |
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| sup-9, sup-10, and unc-93 may encode components of a two-pore K+ channel that coordinates muscle contraction in Caenorhabditis elegans. | de la Cruz IP et al. | β | 2003 | β |
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| The sodium-activated potassium channel is encoded by a member of the Slo gene family. | Yuan A et al. | β | 2003 | β |
| 4-aminopyridine- and dendrotoxin-sensitive potassium channels influence excitability of vagal mechano-sensitive endings in guinea-pig oesophagus. | Zagorodnyuk VP et al. | β | 2002 | β |
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| Expression pattern in the antennae of a newly isolated lepidopteran Gq protein alpha subunit cDNA. | Jacquin-Joly E et al. | β | 2002 | β |
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| The L-type voltage-dependent Ca2+ channel EGL-19 controls body wall muscle function in Caenorhabditis elegans. | Jospin M et al. | β | 2002 | β |
| The synaptic vesicle cycle: exocytosis and endocytosis in Drosophila and C. elegans. | Richmond JE et al. | β | 2002 | β |
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| A cGMP-dependent protein kinase is implicated in wild-type motility in C. elegans. | Stansberry J et al. | β | 2001 | β |
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| Cellular and subcellular localization, N-terminal acylation, and calcium binding of Caenorhabditis elegans protein phosphatase with EF-hands. | Ramulu P et al. | β | 2001 | β |
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| Characterization of the deg-3/des-2 receptor: a nicotinic acetylcholine receptor that mutates to cause neuronal degeneration. | Yassin L et al. | β | 2001 | β |
| Chemotaxis of the nematode Caenorhabditis elegans toward cycloheximide and quinine hydrochloride. | Tajima T et al. | β | 2001 | β |
| Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain. | Cikos S et al. | β | 2001 | β |
| DAF-7/TGF-beta expression required for the normal larval development in C. elegans is controlled by a presumed guanylyl cyclase DAF-11. | Murakami M et al. | β | 2001 | β |
| Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and periphery. | Medhurst AD et al. | β | 2001 | β |
| DLG-1 is a MAGUK similar to SAP97 and is required for adherens junction formation. | Firestein BL et al. | β | 2001 | β |
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| Expression of a CIC chloride channel in Caenorhabditis elegans gamma-aminobutyric acid-ergic neurons. | Bianchi L et al. | β | 2001 | β |
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| Genetic variations and polymorphisms of G protein-coupled receptors: functional and therapeutic implications. | Rana BK et al. | β | 2001 | β |
| Genomic analysis of synaptotagmin genes. | Craxton M | β | 2001 | β |
| GLC-3: a novel fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit from Caenorhabditis elegans. | Horoszok L et al. | β | 2001 | β |
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| G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin. | Ballesteros J et al. | β | 2001 | β |
| GYGD pore motifs in neighbouring potassium channel subunits interact to determine ion selectivity. | Chapman ML et al. | β | 2001 | β |
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| Regulation of distinct attractive and aversive mechanisms mediating benzaldehyde chemotaxis in Caenorhabditis elegans. | Nuttley WM et al. | β | 2001 | β |
| Regulation of distinct muscle behaviors controls the C. elegans male's copulatory spicules during mating. | Garcia LR et al. | β | 2001 | β |
| Stability of membrane proteins: relevance for the selection of appropriate methods for high-resolution structure determinations. | Rosenbusch JP | β | 2001 | β |
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| The guanine protein coupled receptor rhodopsin is developmentally regulated in the free-living stages of Schistosoma mansoni. | Hoffmann KF et al. | β | 2001 | β |
| The role of cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines in manipulation of and evasion from the immune system. | Vink C et al. | β | 2001 | β |
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| What does a worm want with 20,000 genes? | Hodgkin J | β | 2001 | β |
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| A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. | Tissenbaum HA et al. | β | 2000 | β |
| Activation of MAPK cascades by G-protein-coupled receptors: the case of gonadotropin-releasing hormone receptor. | Naor Z et al. | β | 2000 | β |
| A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons. | Millar JA et al. | β | 2000 | β |
| Analysis of the expressed genome of the lone star tick, Amblyomma americanum (Acari: Ixodidae) using an expressed sequence tag approach. | Hill CA et al. | β | 2000 | β |
| An oxygen-, acid- and anaesthetic-sensitive TASK-like background potassium channel in rat arterial chemoreceptor cells. | Buckler KJ et al. | β | 2000 | β |
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| Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. | Kawasawa Y et al. | β | 2000 | β |
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| Classification of transmembrane protein families in the Caenorhabditis elegans genome and identification of human orthologs. | Remm M et al. | β | 2000 | β |
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| Conservation and novelty in the evolution of cell adhesion and extracellular matrix genes. | Hutter H et al. | β | 2000 | β |
| Dauer formation induced by high temperatures in Caenorhabditis elegans. | Ailion M et al. | β | 2000 | β |
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| Group I, II, and III mGluR compounds affect rhythm generation in the gastric circuit of the crustacean stomatogastric ganglion. | Krenz WD et al. | β | 2000 | β |
| Guanylin peptides: renal actions mediated by cyclic GMP. | Forte LR et al. | β | 2000 | β |
| Localization of nAChR subunit mRNAs in the brain of Macaca mulatta. | Han ZY et al. | β | 2000 | β |
| Localization of the tandem pore domain K+ channel TASK-1 in the rat central nervous system. | Kindler CH et al. | β | 2000 | β |
| Long-term nicotine adaptation in Caenorhabditis elegans involves PKC-dependent changes in nicotinic receptor abundance. | Waggoner LE et al. | β | 2000 | β |
| Mechanisms of guanylin action via cyclic GMP in the kidney. | Forte LR et al. | β | 2000 | β |
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| Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system. | Bibel M et al. | β | 2000 | β |
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| Protein interaction mapping in C. elegans using proteins involved in vulval development. | Walhout AJ et al. | β | 2000 | β |
| Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors. | Gutkind JS | β | 2000 | β |
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| Serotonin transporter polymorphism and response to SSRIs in major depression and relevance to anxiety disorders and substance abuse. | Weizman A et al. | β | 2000 | β |
| TASK-3, a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor. | Rajan S et al. | β | 2000 | β |
| The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31. | Hellebrand S et al. | β | 2000 | β |
| The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains. | Fujishige K et al. | β | 2000 | β |
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| The molecular biology of invertebrate voltage-gated Ca(2+) channels. | Jeziorski MC et al. | β | 2000 | β |
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| Using green fluorescent proteins to study G-protein-coupled receptor localization and trafficking. | Kallal L et al. | β | 2000 | β |
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| Ca(2+)/Calmodulin-dependent protein kinase cascade in Caenorhabditis elegans. Implication in transcriptional activation. | Eto K et al. | β | 1999 | β |
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| Disruption of clh-1, a chloride channel gene, results in a wider body of Caenorhabditis elegans. | Petalcorin MI et al. | β | 1999 | β |
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| Fluoxetine-resistant mutants in C. elegans define a novel family of transmembrane proteins. | Choy RK et al. | β | 1999 | β |
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| How do antidepressants work? Prospects for genetic analysis of drug mechanisms. | Schafer WR | β | 1999 | β |
| Identification and characterization of a putative C. elegans potassium channel gene (Ce-slo-2) distantly related to Ca(2+)-activated K(+) channels. | Lim HH et al. | β | 1999 | β |
| Imaging synaptic activity in intact brain and slices with FM1-43 in C. elegans, lamprey, and rat. | Kay AR et al. | β | 1999 | β |
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