Phosphatidylinositol 3-kinase is required for the expression but not for the induction or the maintenance of long-term potentiation in the hippocampal CA1 region.
paper
Cited
Public
Unavailable
- Authors
- Sanna, Pietro Paolo; Cammalleri, Maurizio; Berton, Fulvia; Simpson, Cindy; Lutjens, Robert; Bloom, Floyd E; Francesconi, Walter
- Year
- 2002
- Journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- PMID
- 11978812
- DOI
- 10.1523/JNEUROSCI.22-09-03359.2002
- PMCID
- PMC6758361
Several signal transduction pathways have been implicated in the induction of long-term potentiation (LTP), yet the signal transduction mechanisms behind the maintenance-expression phase of LTP are still poorly understood. We investigated the role of phosphatidylinositol 3-kinase (PI3-kinase) in LTP at Schaffer collateral/commissural fiber-CA1 synapses in rat hippocampal slices using biochemical approaches and extracellular electrophysiological recordings. We observed that PI3-kinase activity was induced in the CA1 region during LTP of field EPSPs (fEPSPs) and that two structurally unrelated PI3-kinase inhibitors, LY294002 and wortmannin, abated established LTP, suggesting that PI3-kinase is involved in the maintenance-expression phase of LTP. However, LTP recovered after washout of the reversible PI3-kinase inhibitor LY294002, confirming that LTP maintenance and expression are distinct events and indicating that PI3-kinase activity is required for LTP expression rather than for its maintenance. Interestingly, preincubation with LY294002 did not prevent LTP induction. In fact, if LY294002 was withdrawn 5 min after high-frequency stimulation, an LTP of fEPSP was seen. Last, a voltage-dependent calcium channel-dependent form of LTP in the CA1 could also be reversibly abated by LY294002, raising the possibility that PI3-kinase could be required for the expression of multiple forms of synaptic potentiation.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Regulation of synaptic function and lipid metabolism. | Zhang T et al. | β | 2026 | β |
| Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives. | Incontro S et al. | β | 2025 | β |
| Modulatory Action of Insulin-like Growth Factor I (IGF-I) on Cortical Activity: Entrainment of Metabolic and Brain Functions. | GarcΓa-Magro N et al. | β | 2025 | β |
| Serotonin signaling in the rat prefrontal cortex is required for Retrieval-Induced Forgetting | Zanoni MB et al. | β | 2025 | β |
| Impairment of synaptic plasticity in the primary somatosensory cortex in a model of diabetic mice. | GarcΓa-Magro N et al. | β | 2024 | β |
| Metabolic and Immune System Dysregulation: Unraveling the Connections between Alzheimer's Disease, Diabetes, Inflammatory Bowel Diseases, and Rheumatoid Arthritis. | Doroszkiewicz J et al. | β | 2024 | β |
| PI3K couples long-term synaptic potentiation with cofilin recruitment and actin polymerization in dendritic spines via its regulatory subunit p85Ξ±. | LΓ³pez-GarcΓa S et al. | β | 2024 | β |
| Activation of the PI3K/AKT/mTOR Pathway in Cajal-Retzius Cells Leads to Their Survival and Increases Susceptibility to Kainate-Induced Seizures. | Ramezanidoraki N et al. | β | 2023 | β |
| Effects of GHRH Deficiency and GHRH Antagonism on Emotional Disorders in Mice. | Recinella L et al. | β | 2023 | β |
| 5-HT-dependent synaptic plasticity of the prefrontal cortex in postnatal development. | Higa GSV et al. | β | 2022 | β |
| Functional specialization of different PI3K isoforms for the control of neuronal architecture, synaptic plasticity, and cognition. | SΓ‘nchez-Castillo C et al. | β | 2022 | β |
| Molecular and Biochemical Pathways Encompassing Diabetes Mellitus and Dementia. | Behl T et al. | β | 2022 | β |
| Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway. | Mutti V et al. | β | 2022 | β |
| Transcriptome and chromatin alterations in social fear indicate association of MEG3 with successful extinction of fear. | Royer M et al. | β | 2022 | β |
| Insulin and Insulin Resistance in Alzheimer's Disease. | SΔdzikowska A et al. | β | 2021 | β |
| GSK-3Ξ² activation is required for ZIP-induced disruption of learned fear. | Song S et al. | β | 2020 | β |
| Akt3 deletion in mice impairs spatial cognition and hippocampal CA1 long long-term potentiation through downregulation of mTOR. | Zhang T et al. | β | 2019 | β |
| Baicalin ameliorates chronic mild stress-induced depression-like behaviors in mice and attenuates inflammatory cytokines and oxidative stress. | Zhong J et al. | β | 2019 | β |
| Enhanced Expression of Secreted Ξ±-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice. | Li D et al. | β | 2019 | β |
| Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases. | Batista AF et al. | β | 2019 | β |
| Tau, Diabetes and Insulin. | Gratuze M et al. | β | 2019 | β |
| Brain STAT5 signaling modulates learning and memory formation. | Furigo IC et al. | β | 2018 | β |
| Dysregulation of PI3K-Akt-mTOR pathway in brain of streptozotocin-induced type 2 diabetes mellitus in Wistar rats. | Bathina S et al. | β | 2018 | β |
| Mutual Relationship between Tau and Central Insulin Signalling: Consequences for AD and Tauopathies? | Gratuze M et al. | β | 2018 | β |
| Physiological and Pathological Roles of 15-Deoxy-Ξ<sup>12,14</sup>-Prostaglandin J<sub>2</sub> in the Central Nervous System and Neurological Diseases. | Yagami T et al. | β | 2018 | β |
| rTMS Ameliorates PTSD Symptoms in Rats by Enhancing Glutamate Transmission and Synaptic Plasticity in the ACC via the PTEN/Akt Signalling Pathway. | Liu G et al. | β | 2018 | β |
| 15-deoxy-Ξ12,14-prostaglandin J2 in neurodegenerative diseases and cancers. | Yagami T et al. | β | 2017 | β |
| 15-Deoxy-Ξ<sup>12,14</sup>-prostaglandin J<sub>2</sub> induced neurotoxicity via suppressing phosphoinositide 3-kinase. | Koma H et al. | β | 2017 | β |
| Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling. | Lao-PeregrΓn C et al. | β | 2017 | β |
| Dynamic Akt/mTOR Signaling in Children with Autism Spectrum Disorder. | Onore C et al. | β | 2017 | β |
| Mice Deficient in <i>lysophosphatidic acid acyltransferase delta</i> (<i>Lpaat</i>Ξ΄)/<i>acylglycerophosphate acyltransferase 4</i> (<i>Agpat4</i>) Have Impaired Learning and Memory. | Bradley RM et al. | β | 2017 | β |
| Neuroinflammatory challenges compromise neuronal function in the aging brain: Postoperative cognitive delirium and Alzheimer's disease. | Cortese GP et al. | β | 2017 | β |
| Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways. | Pirbhoy PS et al. | β | 2017 | β |
| The Activity-Induced Long Non-Coding RNA <i>Meg3</i> Modulates AMPA Receptor Surface Expression in Primary Cortical Neurons. | Tan MC et al. | β | 2017 | β |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
| APPL1 gates long-term potentiation through its plekstrin homology domain. | FernΓ‘ndez-Monreal M et al. | β | 2016 | β |
| Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity. | Wang H et al. | β | 2016 | β |
| Membrane-tethered AKT kinase regulates basal synaptic transmission and early phase LTP expression by modulation of post-synaptic AMPA receptor level. | Pen Y et al. | β | 2016 | β |
| Peripheral Administration of GSK-3Ξ² Antisense Oligonucleotide Improves Learning and Memory in SAMP8 andΒ Tg2576 Mouse Models of Alzheimer's Disease. | Farr SA et al. | β | 2016 | β |
| PI3-kinase cascade has a differential role in acquisition and extinction of conditioned fear memory in juvenile and adult rats. | Slouzkey I et al. | β | 2016 | β |
| Stromal Cell-Derived Factor 1 Increases Tetrodotoxin-Resistant Sodium Currents Nav1.8 and Nav1.9 in Rat Dorsal Root Ganglion Neurons via Different Mechanisms. | Qiu F et al. | β | 2016 | β |
| The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia. | Enriquez-Barreto L et al. | β | 2016 | β |
| Asiaticoside attenuates diabetes-induced cognition deficits by regulating PI3K/Akt/NF-ΞΊB pathway. | Yin Z et al. | β | 2015 | β |
| Dynamical properties of gene regulatory networks involved in long-term potentiation. | Nido GS et al. | β | 2015 | β |
| Function of insulin in snail brain in associative learning. | Kojima S et al. | β | 2015 | β |
| Inhibition of Protein Kinases AKT and ERK1/2 Reduce the Carotid Body Chemoreceptor Response to Hypoxia in Adult Rats. | Iturri P et al. | β | 2015 | β |
| Molecular and biochemical trajectories from diabetes to Alzheimer's disease: A critical appraisal. | Sandhir R et al. | β | 2015 | β |
| Phosphoinositide dynamics in the postsynaptic membrane compartment: Mechanisms and experimental approach. | Leitner MG et al. | β | 2015 | β |
| Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes. | Laedermann CJ et al. | β | 2015 | β |
| Does autophagy work in synaptic plasticity and memory? | Shehata M et al. | β | 2014 | β |
| Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. | Repunte-Canonigo V et al. | β | 2014 | β |
| Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus. | Ribeiro LF et al. | β | 2014 | β |
| Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor. | Nakai T et al. | β | 2014 | β |
| Learning improvement after PI3K activation correlates with de novo formation of functional small spines. | Enriquez-Barreto L et al. | β | 2014 | β |
| Modulation of BK channels contributes to activity-dependent increase of excitability through MTORC1 activity in CA1 pyramidal cells of mouse hippocampus. | Springer SJ et al. | β | 2014 | β |
| Neuron-specific regulation of class I PI3K catalytic subunits and their dysfunction in brain disorders. | Gross C et al. | β | 2014 | β |
| PTEN: A master regulator of neuronal structure, function, and plasticity. | Garcia-Junco-Clemente P et al. | β | 2014 | β |
| PTEN counteracts PIP3 upregulation in spines during NMDA-receptor-dependent long-term depression. | Arendt KL et al. | β | 2014 | β |
| Signaling mechanisms involved in the acute effects of estradiol on 5-HT clearance. | Benmansour S et al. | β | 2014 | β |
| Structural basis of PI(4,5)P2-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A). | Seebohm G et al. | β | 2014 | β |
| The role of phosphoinositides in synapse function. | Ueda Y | β | 2014 | β |
| Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis. | Briz V et al. | β | 2013 | β |
| Elevated RalA activity in the hippocampus of PI3KΞ³ knock-out mice lacking NMDAR-dependent long-term depression. | Sim SE et al. | β | 2013 | β |
| Fluoxetine upregulates phosphorylated-AKT and phosphorylated-ERK1/2 proteins in neural stem cells: evidence for a crosstalk between AKT and ERK1/2 pathways. | Huang W et al. | β | 2013 | β |
| Involvement of insulin-like peptide in long-term synaptic plasticity and long-term memory of the pond snail Lymnaea stagnalis. | Murakami J et al. | β | 2013 | β |
| Neurotoxicity of developmental hypothyroxinemia and hypothyroidism in rats: Impairments of long-term potentiation are mediated by phosphatidylinositol 3-kinase signaling pathway. | Wang Y et al. | β | 2013 | β |
| NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia. | Snyder MA et al. | β | 2013 | β |
| PKCΞ» is critical in AMPA receptor phosphorylation and synaptic incorporation during LTP. | Ren SQ et al. | β | 2013 | β |
| Protein kinase B/Akt is required for complete Freund's adjuvant-induced upregulation of Nav1.7 and Nav1.8 in primary sensory neurons. | Liang L et al. | β | 2013 | β |
| The molecular events involved in oligodendrocyte precursor cell proliferation induced by the conditioned medium from b104 neuroblastoma cells. | Hu JG et al. | β | 2013 | β |
| The role of Ξ³-secretase in hippocampal synaptic transmission and activity-dependent synaptic plasticity. | Chen Y et al. | β | 2013 | β |
| Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin. | Rosales-Corral SA et al. | β | 2012 | β |
| Berberine ameliorates Ξ²-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model. | Durairajan SS et al. | β | 2012 | β |
| Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity. | Costello DA et al. | β | 2012 | β |
| Brain-derived neurotrophic factor-dependent synaptic plasticity is suppressed by interleukin-1Ξ² via p38 mitogen-activated protein kinase. | Tong L et al. | β | 2012 | β |
| Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase. | Wildburger NC et al. | β | 2012 | β |
| Estradiol acts via estrogen receptors alpha and beta on pathways important for synaptic plasticity in the mouse hippocampal formation. | Spencer-Segal JL et al. | β | 2012 | β |
| Insulin and memory in Lymnaea. | Ito E et al. | β | 2012 | β |
| PI3K/Akt signaling pathway in the basolateral amygdala mediates the rapid antidepressant-like effects of trefoil factor 3. | Shi HS et al. | β | 2012 | β |
| PI 3-kinase and PKCΞΆ mediate insulin-induced potentiation of NMDA receptor currents in Xenopus oocytes. | Jones ML et al. | β | 2012 | β |
| Role of phosphoinositides at the neuronal synapse. | Frere SG et al. | β | 2012 | β |
| AKT signaling pathway in the nucleus accumbens mediates excessive alcohol drinking behaviors. | Neasta J et al. | β | 2011 | β |
| Effects of estrogen and aging on the synaptic distribution of phosphorylated Akt-immunoreactivity in the CA1 region of the female rat hippocampus. | Yildirim M et al. | β | 2011 | β |
| Expression profiling reveals differential gene induction underlying specific and non-specific memory for pheromones in mice. | Upadhya SC et al. | β | 2011 | β |
| Genetic enhancement of behavioral itch responses in mice lacking phosphoinositide 3-kinase-Ξ³ (PI3KΞ³). | Lee B et al. | β | 2011 | β |
| GSK3 Function in the Brain during Development, Neuronal Plasticity, and Neurodegeneration. | Salcedo-Tello P et al. | β | 2011 | β |
| Modulation of fear memory by retrieval and extinction: a clue for memory deconsolidation. | Hong I et al. | β | 2011 | β |
| NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. | Yokoyama K et al. | β | 2011 | β |
| Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons. | Cuesto G et al. | β | 2011 | β |
| PI3KΞ³ is required for NMDA receptor-dependent long-term depression and behavioral flexibility. | Kim JI et al. | β | 2011 | β |
| PIKE-mediated PI3-kinase activity is required for AMPA receptor surface expression. | Chan CB et al. | β | 2011 | β |
| Signalling pathways underlying structural plasticity of dendritic spines. | Patterson M et al. | β | 2011 | β |
| A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake. | Repunte-Canonigo V et al. | β | 2010 | β |
| BDNF variant Val66Met interacts with estrous cycle in the control of hippocampal function. | Spencer JL et al. | β | 2010 | β |
| Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. | Jackson C et al. | β | 2010 | β |
| Early growth response-1 induction by fibroblast growth factor-1 via increase of mitogen-activated protein kinase and inhibition of protein kinase B in hippocampal neurons. | Benz AH et al. | β | 2010 | β |
| Extracellular signal-regulated kinase and phosphatidylinositol-3-kinase/AKT signalling pathways in the human carotid body and peripheral ganglia. | Porzionato A et al. | β | 2010 | β |
| Phosphorylation changes of CaMKII, ERK1/2, PKB/Akt kinases and CREB activation during early long-term potentiation at Schaffer collateral-CA1 mouse hippocampal synapses. | Racaniello M et al. | β | 2010 | β |
| PIP3 controls synaptic function by maintaining AMPA receptor clustering at the postsynaptic membrane. | Arendt KL et al. | β | 2010 | β |
| Protein degradation by the proteasome is required for synaptic tagging and the heterosynaptic stabilization of hippocampal late-phase long-term potentiation. | Cai F et al. | β | 2010 | β |
| PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. | Jurado S et al. | β | 2010 | β |
| Simvastatin enhances hippocampal long-term potentiation in C57BL/6 mice. | Mans RA et al. | β | 2010 | β |
| Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins. | Ye X et al. | β | 2010 | β |
| Tumour necrosis factor alpha induces rapid reduction in AMPA receptor-mediated calcium entry in motor neurones by increasing cell surface expression of the GluR2 subunit: relevance to neurodegeneration. | Rainey-Smith SR et al. | β | 2010 | β |
| Ca(2+) permeable AMPA receptor induced long-term potentiation requires PI3/MAP kinases but not Ca/CaM-dependent kinase II. | Asrar S et al. | β | 2009 | β |
| DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. | Kim JY et al. | β | 2009 | β |
| GSK3beta, a centre-staged kinase in neuropsychiatric disorders, modulates long term memory by inhibitory phosphorylation at serine-9. | Dewachter I et al. | β | 2009 | β |
| Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus. | Welsby PJ et al. | β | 2009 | β |
| Phosphoinositide 3-kinase is required for bombesin-induced enhancement of fear memory consolidation in the hippocampus. | Roesler R et al. | β | 2009 | β |
| Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis. | Francesconi W et al. | β | 2009 | β |
| Abeta(1-42) modulation of Akt phosphorylation via alpha7 nAChR and NMDA receptors. | Abbott JJ et al. | β | 2008 | β |
| Administration of triiodo-L-thyronine into dorsal hippocampus alters phosphorylation of Akt, mammalian target of rapamycin, p70S6 kinase and 4E-BP1 in rats. | Sui L et al. | β | 2008 | β |
| AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. | Krishnan V et al. | β | 2008 | β |
| An analysis of the stimulus requirements for setting the molecular switch reveals a lower threshold for metaplasticity than synaptic plasticity. | Bortolotto ZA et al. | β | 2008 | β |
| Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling. | Nakamura A et al. | β | 2008 | β |
| Homocysteine activates calcium-mediated cell signaling mechanisms targeting the cytoskeleton in rat hippocampus. | Loureiro SO et al. | β | 2008 | β |
| Hormonal regulation of hippocampal dendritic morphology and synaptic plasticity. | Moult PR et al. | β | 2008 | β |
| Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescents. | DesriviΓ¨res S et al. | β | 2008 | β |
| Phosphatidylinositol 3-kinase activation is required for stress protocol-induced modification of hippocampal synaptic plasticity. | Yang PC et al. | β | 2008 | β |
| Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions. | Pezet S et al. | β | 2008 | β |
| PKMzeta, LTP maintenance, and the dynamic molecular biology of memory storage. | Sacktor TC | β | 2008 | β |
| Platelet-derived growth factor-AA mediates oligodendrocyte lineage differentiation through activation of extracellular signal-regulated kinase signaling pathway. | Hu JG et al. | β | 2008 | β |
| Regulation of psychostimulant-induced signaling and gene expression in the striatum. | McGinty JF et al. | β | 2008 | β |
| Removal of S6K1 and S6K2 leads to divergent alterations in learning, memory, and synaptic plasticity. | Antion MD et al. | β | 2008 | β |
| Role of the phosphoinositide 3-kinase-Akt-mammalian target of the rapamycin signaling pathway in long-term potentiation and trace fear conditioning memory in rat medial prefrontal cortex. | Sui L et al. | β | 2008 | β |
| Temporal correlation of the memory deficit with Alzheimer-like lesions induced by activation of glycogen synthase kinase-3. | Wang Y et al. | β | 2008 | β |
| The GSK3 hypothesis of Alzheimer's disease. | Hooper C et al. | β | 2008 | β |
| Activation of phosphatidylinositol 3-kinase and protein kinase B/Akt in dorsal root ganglia and spinal cord contributes to the neuropathic pain induced by spinal nerve ligation in rats. | Xu JT et al. | β | 2007 | β |
| Activation of protein kinase B/Akt in the periphery contributes to pain behavior induced by capsaicin in rats. | Sun R et al. | β | 2007 | β |
| Brain-derived neurotrophic factor and its intracellular signaling pathways in cocaine addiction. | Corominas M et al. | β | 2007 | β |
| Effects of relative hypoglycemia on LTP and NADH imaging in rat hippocampal slices. | Sadgrove MP et al. | β | 2007 | β |
| Glycogen synthase kinase-3 inhibition is integral to long-term potentiation. | Hooper C et al. | β | 2007 | β |
| LTP forms 1, 2 and 3: different mechanisms for the "long" in long-term potentiation. | Raymond CR | β | 2007 | β |
| Mitogen-activated protein kinase upregulates the dendritic translation machinery in long-term potentiation by controlling the mammalian target of rapamycin pathway. | Tsokas P et al. | β | 2007 | β |
| Polyphosphoinositol lipids: under-PPInning synaptic function in health and disease. | Hammond GR et al. | β | 2007 | β |
| Pyrrolidine dithiocarbamate activates Akt and improves spatial learning in APP/PS1 mice without affecting beta-amyloid burden. | Malm TM et al. | β | 2007 | β |
| Regulation of protein kinase Mzeta synthesis by multiple kinases in long-term potentiation. | Kelly MT et al. | β | 2007 | β |
| Restored plasticity in a mouse model of neurofibromatosis type 1 via inhibition of hyperactive ERK and CREB. | Guilding C et al. | β | 2007 | β |
| Reversal of synaptic memory by Ca2+/calmodulin-dependent protein kinase II inhibitor. | Sanhueza M et al. | β | 2007 | β |
| The different roles of cyclinD1-CDK4 in STP and mGluR-LTD during the postnatal development in mice hippocampus area CA1. | Li C et al. | β | 2007 | β |
| The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. | Brandt N et al. | β | 2007 | β |
| Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensitivity induced by capsaicin. | Sun RQ et al. | β | 2006 | β |
| Activity- and mTOR-dependent suppression of Kv1.1 channel mRNA translation in dendrites. | Raab-Graham KF et al. | β | 2006 | β |
| Altered signaling pathways underlying abnormal hippocampal synaptic plasticity in the Ts65Dn mouse model of Down syndrome. | Siarey RJ et al. | β | 2006 | β |
| A model of the roles of essential kinases in the induction and expression of late long-term potentiation. | Smolen P et al. | β | 2006 | β |
| Differential reelin-induced enhancement of NMDA and AMPA receptor activity in the adult hippocampus. | Qiu S et al. | β | 2006 | β |
| Estrogen receptor protein interaction with phosphatidylinositol 3-kinase leads to activation of phosphorylated Akt and extracellular signal-regulated kinase 1/2 in the same population of cortical neurons: a unified mechanism of estrogen action. | Mannella P et al. | β | 2006 | β |
| Extinction training in conjunction with a partial agonist of the glycine site on the NMDA receptor erases memory trace. | Mao SC et al. | β | 2006 | β |
| Inhibition of the spinal phosphoinositide 3-kinase exacerbates morphine withdrawal response. | Yang L et al. | β | 2006 | β |
| Insulin receptor deficits in schizophrenia and in cellular and animal models of insulin receptor dysfunction. | Zhao Z et al. | β | 2006 | β |
| Insulin signaling in the central nervous system: learning to survive. | van der Heide LP et al. | β | 2006 | β |
| Interaction between interferon gamma and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation. | Maher FO et al. | β | 2006 | β |
| Involvement of multiple phosphatidylinositol 3-kinase-dependent pathways in the persistence of late-phase long term potentiation expression. | Karpova A et al. | β | 2006 | β |
| Phosphatidylinositol 3 kinase activation and AMPA receptor subunit trafficking underlie the potentiation of miniature EPSC amplitudes triggered by the activation of L-type calcium channels. | Baxter AW et al. | β | 2006 | β |
| PI3 kinase is involved in cocaine behavioral sensitization and its reversal with brain area specificity. | Zhang X et al. | β | 2006 | β |
| SGK protein kinase facilitates the expression of long-term potentiation in hippocampal neurons. | Ma YL et al. | β | 2006 | β |
| Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat. | Horwood JM et al. | β | 2006 | β |
| Simvastatin enhances learning and memory independent of amyloid load in mice. | Li L et al. | β | 2006 | β |
| Synaptic incorporation of AMPA receptors during LTP is controlled by a PKC phosphorylation site on GluR1. | Boehm J et al. | β | 2006 | β |
| Synaptic Ras GTPase activating protein regulates pattern formation in the trigeminal system of mice. | Barnett MW et al. | β | 2006 | β |
| The growing role of mTOR in neuronal development and plasticity. | Jaworski J et al. | β | 2006 | β |
| The PTEN phosphatase is essential for long-term depression of hippocampal synapses. | Wang Y et al. | β | 2006 | β |
| Activity-dependent phosphorylation of Akt/PKB in adult DRG neurons. | Pezet S et al. | β | 2005 | β |
| Cascade models of synaptically stored memories. | Fusi S et al. | β | 2005 | β |
| Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway. | Jaworski J et al. | β | 2005 | β |
| Differential translation and fragile X syndrome. | Vanderklish PW et al. | β | 2005 | β |
| Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. | Tschopp O et al. | β | 2005 | β |
| Functional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus. | Ramsey MM et al. | β | 2005 | β |
| Glutamatergic regulation of the p70S6 kinase in primary mouse neurons. | Lenz G et al. | β | 2005 | β |
| Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner. | van der Heide LP et al. | β | 2005 | β |
| Intraneuronal beta-amyloid expression downregulates the Akt survival pathway and blunts the stress response. | MagranΓ© J et al. | β | 2005 | β |
| Leptin induces a novel form of NMDA receptor-dependent long-term depression. | Durakoglugil M et al. | β | 2005 | β |
| Neurodevelopment, neuroplasticity, and new genes for schizophrenia. | Arnold SE et al. | β | 2005 | β |
| Norepinephrine triggers release of glial ATP to increase postsynaptic efficacy. | Gordon GR et al. | β | 2005 | β |
| PI3 kinase signaling is required for retrieval and extinction of contextual memory. | Chen X et al. | β | 2005 | β |
| Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3. | Strutz-Seebohm N et al. | β | 2005 | β |
| State-dependent Ras signaling and AMPA receptor trafficking. | Qin Y et al. | β | 2005 | β |
| The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines. | Tolias KF et al. | β | 2005 | β |
| The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors. | Bortolotto ZA et al. | β | 2005 | β |
| Two distinct regulatory mechanisms of neurotransmitter release by phosphatidylinositol 3-kinase. | Itakura M et al. | β | 2005 | β |
| Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. | Hou L et al. | β | 2004 | β |
| AMPA-receptor activation regulates the diffusion of a membrane marker in parallel with dendritic spine motility in the mouse hippocampus. | Richards DA et al. | β | 2004 | β |
| Biochemical mechanisms for translational regulation in synaptic plasticity. | Klann E et al. | β | 2004 | β |
| Inhibiting Src family tyrosine kinase activity blocks glutamate signalling to ERK1/2 and Akt/PKB but not JNK in cultured striatal neurones. | Crossthwaite AJ et al. | β | 2004 | β |
| Insulin and the insulin receptor in experimental models of learning and memory. | Zhao WQ et al. | β | 2004 | β |
| Long-term potentiation and memory. | Lynch MA | β | 2004 | β |
| MAPK cascade signalling and synaptic plasticity. | Thomas GM et al. | β | 2004 | β |
| Neuronal roles of the integrin-associated protein (IAP/CD47) in developing cortical neurons. | Numakawa T et al. | β | 2004 | β |
| Performance in long-term memory tasks is augmented by a phosphorylated growth factor receptor fragment. | Dash PK et al. | β | 2004 | β |
| Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. | Zhuang ZY et al. | β | 2004 | β |
| Removal of G(ialpha1) constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formation. | Pineda VV et al. | β | 2004 | β |
| Synaptic plasticity and translation initiation. | Klann E et al. | β | 2004 | β |
| The involvement of PTEN in sleep deprivation-induced memory impairment in rats. | Su CL et al. | β | 2004 | β |
| The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region. | Francesconi W et al. | β | 2004 | β |
| Transient phosphatidylinositol 3-kinase inhibition protects immature primary cortical neurons from oxidative toxicity via suppression of extracellular signal-regulated kinase activation. | Levinthal DJ et al. | β | 2004 | β |
| 6-Ethyl-N,N'-bis(3-hydroxyphenyl)[1,3,5]triazine-2,4-diamine (RS-0466) enhances the protective effect of brain-derived neurotrophic factor on amyloid beta-induced cytotoxicity in cortical neurones. | Kubo T et al. | β | 2003 | β |
| Activation of PI3-kinase is required for AMPA receptor insertion during LTP of mEPSCs in cultured hippocampal neurons. | Man HY et al. | β | 2003 | β |
| Control of synaptic strength, a novel function of Akt. | Wang Q et al. | β | 2003 | β |
| Focal adhesion kinase is required, but not sufficient, for the induction of long-term potentiation in dentate gyrus neurons in vivo. | Yang YC et al. | β | 2003 | β |
| Hippocampal gene expression profiling in spatial discrimination learning. | Robles Y et al. | β | 2003 | β |
| Long-term potentiation: outstanding questions and attempted synthesis. | Lisman J | β | 2003 | β |
| Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death. | Mattson MP et al. | β | 2003 | β |
| Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular signal-related kinase-independent mechanisms. | Opazo P et al. | β | 2003 | β |
| Polymorphism screening of PIP5K2A: a candidate gene for chromosome 10p-linked psychiatric disorders. | Stopkova P et al. | β | 2003 | β |
| Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1. | Cammalleri M et al. | β | 2003 | β |
| A novel compound RS-0466 reverses beta-amyloid-induced cytotoxicity through the Akt signaling pathway in vitro. | Nakagami Y et al. | β | 2002 | β |
| Intrahippocampal wortmannin infusion enhances long-term spatial and contextual memories. | Dash PK et al. | β | 2002 | β |
| Neural plasticity and addiction: PI3-kinase and cocaine behavioral sensitization. | Izzo E et al. | β | 2002 | β |
| Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression. | Daw MI et al. | β | 2002 | β |
| Postsynaptic signaling and plasticity mechanisms. | Sheng M et al. | β | 2002 | β |
| SynGAP regulates ERK/MAPK signaling, synaptic plasticity, and learning in the complex with postsynaptic density 95 and NMDA receptor. | Komiyama NH et al. | β | 2002 | β |