Structural and functional diversity of native brain neuronal nicotinic receptors.
paper
Cited
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- Authors
- Gotti, Cecilia; Clementi, Francesco; Fornari, Alice; Gaimarri, Annalisa; Guiducci, Stefania; Manfredi, Irene; Moretti, Milena; Pedrazzi, Patrizia; Pucci, Luca; Zoli, Michele
- Year
- 2009
- Journal
- Biochemical pharmacology
- PMID
- 19481063
- DOI
- 10.1016/j.bcp.2009.05.024
Neuronal nicotinic acetylcholine receptors (nAChRs) are a family of ligand-gated ion channels present in the central and peripheral nervous systems, that are permeable to mono- and divalent cations. They share a common basic structure but their pharmacological and functional properties arise from the wide range of different subunit combinations making up distinctive subtypes. nAChRs are involved in many physiological functions in the central and peripheral nervous systems, and are the targets of the widely used drug of abuse nicotine. In addition to tobacco dependence, changes in their number and/or function are associated with neuropsychiatric disorders, ranging from epilepsy to dementia. Although some of the neural circuits involved in the acute and chronic effects of nicotine have been identified, much less is known about which native nAChR subtypes are involved in specific physiological functions and pathophysiological conditions. We briefly review some recent findings concerning the structure and function of native nAChRs, focusing on the subtypes identified in the mesostriatal and habenulo-interpeduncular pathways, two systems involved in nicotine reinforcement and withdrawal. We also discuss recent findings concerning the effect of chronic nicotine on the expression of native subtypes.
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| Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration. | Eskildsen J et al. | β | 2014 | β |
| Diverse strategies targeting Ξ±7 homomeric and Ξ±6Ξ²2* heteromeric nicotinic acetylcholine receptors for smoking cessation. | Brunzell DH et al. | β | 2014 | β |
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| Ginseng ginsenoside pharmacology in the nervous system: involvement in the regulation of ion channels and receptors. | Nah SY | β | 2014 | β |
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| Lynx1 shifts Ξ±4Ξ²2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum. | Nichols WA et al. | β | 2014 | β |
| Merging old and new perspectives on nicotinic acetylcholine receptors. | Papke RL | β | 2014 | β |
| Neuropharmacological modulation of the P3-like event-related potential in a rat two-tone auditory discrimination task with modafinil and NS9283, a positive allosteric modulator of Ξ±4Ξ²2 nAChRs. | Grupe M et al. | β | 2014 | β |
| Nicotine consumption is regulated by a human polymorphism in dopamine neurons. | Morel C et al. | β | 2014 | β |
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| Possible role of the Ξ±7 nicotinic receptors in mediating nicotine's effect on developing lung - implications in unexplained human perinatal death. | Lavezzi AM et al. | β | 2014 | β |
| Presence of multiple binding sites on Ξ±9Ξ±10 nAChR receptors alludes to stoichiometric-dependent action of the Ξ±-conotoxin, Vc1.1. | Indurthi DC et al. | β | 2014 | β |
| Presynaptic GABAB autoreceptor regulation of nicotinic acetylcholine receptor mediated [(3)H]-GABA release from mouse synaptosomes. | McClure-Begley TD et al. | β | 2014 | β |
| Recent developments in novel antidepressants targeting Ξ±4Ξ²2-nicotinic acetylcholine receptors. | Yu LF et al. | β | 2014 | β |
| Regulatory effect of nicotine on collagen-induced arthritis and on the induction and function of in vitro-cultured Th17 cells. | Yang Y et al. | β | 2014 | β |
| Scientific overview: 2013 BBC plenary symposium on tobacco addiction. | De Biasi M et al. | β | 2014 | β |
| Single dose varenicline may trigger epileptic activity. | Erken HA et al. | β | 2014 | β |
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| Targeting the interaction between fatty acid ethanolamides and nicotinic receptors: therapeutic perspectives. | Melis M et al. | β | 2014 | β |
| The cytisine derivatives, CC4 and CC26, reduce nicotine-induced conditioned place preference in zebrafish by acting on heteromeric neuronal nicotinic acetylcholine receptors. | Ponzoni L et al. | β | 2014 | β |
| The potent and selective Ξ±4Ξ²2*/Ξ±6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile. | Yu LF et al. | β | 2014 | β |
| The role of nicotinic receptors in shaping and functioning of the glutamatergic system: a window into cognitive pathology. | Molas S et al. | β | 2014 | β |
| The unique Ξ±4+/-Ξ±4 agonist binding site in (Ξ±4)3(Ξ²2)2 subtype nicotinic acetylcholine receptors permits differential agonist desensitization pharmacology versus the (Ξ±4)2(Ξ²2)3 subtype. | Eaton JB et al. | β | 2014 | β |
| Activation of Ξ±7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses. | Wang X et al. | β | 2013 | β |
| Acute activation, desensitization and smoldering activation of human acetylcholine receptors. | Campling BG et al. | β | 2013 | β |
| A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target. | Saur T et al. | β | 2013 | β |
| Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia. | Wallace TL et al. | β | 2013 | β |
| Alternative CHRNB4 3'-UTRs mediate the allelic effects of SNP rs1948 on gene expression. | Gallego X et al. | β | 2013 | β |
| Biogenesis, trafficking and up-regulation of nicotinic ACh receptors. | Colombo SF et al. | β | 2013 | β |
| CC4, a dimer of cytisine, is a selective partial agonist at Ξ±4Ξ²2/Ξ±6Ξ²2 nAChR with improved selectivity for tobacco smoking cessation. | Sala M et al. | β | 2013 | β |
| Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective Ξ±4Ξ²2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II. | Zhang HK et al. | β | 2013 | β |
| Cross-species analysis of nicotine-induced proteomic alterations in pancreatic cells. | Paulo JA et al. | β | 2013 | β |
| Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of Ξ±7 nicotinic acetylcholine receptors. | Hogenkamp DJ et al. | β | 2013 | β |
| Design, synthesis and discovery of picomolar selective Ξ±4Ξ²2 nicotinic acetylcholine receptor ligands. | Yenugonda VM et al. | β | 2013 | β |
| Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of Ξ±7 nicotinic acetylcholine receptors. | Thakur GA et al. | β | 2013 | β |
| Exploring the nicotinic acetylcholine receptor-associated proteome with iTRAQ and transgenic mice. | McClure-Begley TD et al. | β | 2013 | β |
| Human neuromodulator SLURP-1: bacterial expression, binding to muscle-type nicotinic acetylcholine receptor, secondary structure, and conformational heterogeneity in solution. | Shulepko MA et al. | β | 2013 | β |
| (+)-Laburnamine, a natural selective ligand and partial agonist for the Ξ±4Ξ²2 nicotinic receptor subtype. | Tasso B et al. | β | 2013 | β |
| Lidocaine effects on acetylcholine-elicited currents from mouse superior cervical ganglion neurons. | Alberola-Die A et al. | β | 2013 | β |
| Neuronal nicotinic receptor agonists ameliorate spontaneous motor asymmetries and motor discoordination in a unilateral mouse model of Parkinson's disease. | Kucinski A et al. | β | 2013 | β |
| Nicotine-mediated improvement in L-dopa-induced dyskinesias in MPTP-lesioned monkeys is dependent on dopamine nerve terminal function. | Quik M et al. | β | 2013 | β |
| Nicotine-modulated subunit stoichiometry affects stability and trafficking of Ξ±3Ξ²4 nicotinic receptor. | Mazzo F et al. | β | 2013 | β |
| Nicotine reduces established levodopa-induced dyskinesias in a monkey model of Parkinson's disease. | Quik M et al. | β | 2013 | β |
| Nicotinic acetylcholine receptors controlling attention: behavior, circuits and sensitivity to disruption by nicotine. | Poorthuis RB et al. | β | 2013 | β |
| Nicotinic acetylcholine receptors: from basic science to therapeutics. | Hurst R et al. | β | 2013 | β |
| Nicotinic receptor agonists reduce L-DOPA-induced dyskinesias in a monkey model of Parkinson's disease. | Zhang D et al. | β | 2013 | β |
| Nicotinic receptors in neurodegeneration. | Posadas I et al. | β | 2013 | β |
| Plant toxins that affect nicotinic acetylcholine receptors: a review. | Green BT et al. | β | 2013 | β |
| Regulation of glutamate release by heteromeric nicotinic receptors in layer V of the secondary motor region (Fr2) in the dorsomedial shoulder of prefrontal cortex in mouse. | Aracri P et al. | β | 2013 | β |
| Selective potentiation of (Ξ±4)3(Ξ²2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal acetylcholine- and nicotine-evoked glutamatergic transients in rats. | Grupe M et al. | β | 2013 | β |
| Similar activity of mecamylamine stereoisomers in vitro and in vivo. | Papke RL et al. | β | 2013 | β |
| The Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels. | Alexander SP et al. | β | 2013 | β |
| The potential of nicotinic enhancement of cognitive remediation training in schizophrenia. | Hahn B et al. | β | 2013 | β |
| The Ξ±5 neuronal nicotinic acetylcholine receptor subunit plays an important role in the sedative effects of ethanol but does not modulate consumption in mice. | Santos N et al. | β | 2013 | β |
| The Ξ±5 subunit regulates the expression and function of Ξ±4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area. | Chatterjee S et al. | β | 2013 | β |
| Tobacco nitrosamine N-nitrosonornicotine as inhibitor of neuronal nicotinic acetylcholine receptors. | Nunes-Alves A et al. | β | 2013 | β |
| Unraveling the neurobiology of nicotine dependence using genetically engineered mice. | Stoker AK et al. | β | 2013 | β |
| Ξ±4Ξ²2 Nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats. | Quik M et al. | β | 2013 | β |
| Ξ±7-Containing nicotinic acetylcholine receptors on interneurons of the basolateral amygdala and their role in the regulation of the network excitability. | Pidoplichko VI et al. | β | 2013 | β |
| [Β³H]Chiba-1001(methyl-SSR180711) has low in vitro binding affinity and poor in vivo selectivity to nicotinic alpha-7 receptor in rodent brain. | Ding M et al. | β | 2012 | β |
| A novel Ξ±-conotoxin MII-sensitive nicotinic acetylcholine receptor modulates [(3) H]-GABA release in the superficial layers of the mouse superior colliculus. | McClure-Begley TD et al. | β | 2012 | β |
| Bimodal effects of fluoxetine on cerebral nitrergic neurogenic vasodilation in porcine large cerebral arteries. | Chen MF et al. | β | 2012 | β |
| Chemistry and behavioral studies identify chiral cyclopropanes as selective Ξ±4Ξ²2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. | Zhang H et al. | β | 2012 | β |
| Discovery of highly potent and selective Ξ±4Ξ²2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II. | Yu LF et al. | β | 2012 | β |
| Efficient binding of 4/7 Ξ±-conotoxins to nicotinic Ξ±4Ξ²2 receptors is prevented by Arg185 and Pro195 in the Ξ±4 subunit. | Beissner M et al. | β | 2012 | β |
| Exercise and melatonin in humans: reciprocal benefits. | Escames G et al. | β | 2012 | β |
| Function of human Ξ±3Ξ²4Ξ±5 nicotinic acetylcholine receptors is reduced by the Ξ±5(D398N) variant. | George AA et al. | β | 2012 | β |
| Glutamatergic synapse formation is promoted by Ξ±7-containing nicotinic acetylcholine receptors. | Lozada AF et al. | β | 2012 | β |
| Identification of novel Ξ±4Ξ²2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity. | Yu LF et al. | β | 2012 | β |
| Induction of dendritic spines by Ξ²2-containing nicotinic receptors. | Lozada AF et al. | β | 2012 | β |
| Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to Ξ±4Ξ²2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands. | Zhang HK et al. | β | 2012 | β |
| Ion channels and schizophrenia: a gene set-based analytic approach to GWAS data for biological hypothesis testing. | Askland K et al. | β | 2012 | β |
| Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions. | Feduccia AA et al. | β | 2012 | β |
| Neuronal nicotinic receptors in sleep-related epilepsy: studies in integrative biology. | Becchetti A | β | 2012 | β |
| Nicotine reduces antipsychotic-induced orofacial dyskinesia in rats. | Bordia T et al. | β | 2012 | β |
| Nocturnal frontal lobe epilepsy and the acetylcholine receptor. | Ferini-Strambi L et al. | β | 2012 | β |
| Overexpression of the CHRNA5/A3/B4 genomic cluster in mice increases the sensitivity to nicotine and modifies its reinforcing effects. | Gallego X et al. | β | 2012 | β |
| Prenatal nicotine exposure alters lung function and airway geometry through Ξ±7 nicotinic receptors. | Wongtrakool C et al. | β | 2012 | β |
| Replication of association of CHRNA4 rare variants with sporadic amyotrophic lateral sclerosis: the Italian multicentre study. | Sabatelli M et al. | β | 2012 | β |
| Role of Ξ±7- and Ξ²4-containing nicotinic acetylcholine receptors in the affective and somatic aspects of nicotine withdrawal: studies in knockout mice. | Stoker AK et al. | β | 2012 | β |
| Smoking, quitting, and psychiatric disease: a review. | Aubin HJ et al. | β | 2012 | β |
| Specificity determinants of allosteric modulation in the neuronal nicotinic acetylcholine receptor: a fine line between inhibition and potentiation. | Cesa LC et al. | β | 2012 | β |
| The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses. | Lubke GH et al. | β | 2012 | β |
| Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases. | Bencherif M et al. | β | 2011 | β |
| Anatomical differences and network characteristics underlying smoking cue reactivity. | Zhang X et al. | β | 2011 | β |
| An autoradiographic survey of mouse brain nicotinic acetylcholine receptors defined by null mutants. | Baddick CG et al. | β | 2011 | β |
| An unusual phospholipase Aβ from puff adder Bitis arietans venom--a novel blocker of nicotinic acetylcholine receptors. | Vulfius CA et al. | β | 2011 | β |
| Assembly of nicotinic and other Cys-loop receptors. | Tsetlin V et al. | β | 2011 | β |
| Aversion to nicotine is regulated by the balanced activity of Ξ²4 and Ξ±5 nicotinic receptor subunits in the medial habenula. | Frahm S et al. | β | 2011 | β |
| Discovery of isoxazole analogues of sazetidine-A as selective Ξ±4Ξ²2-nicotinic acetylcholine receptor partial agonists for the treatment of depression. | Liu J et al. | β | 2011 | β |
| Dopamine signaling in dorsal versus ventral striatum: the dynamic role of cholinergic interneurons. | Threlfell S et al. | β | 2011 | β |
| Emergent pharmacology of conscious experience: new perspectives in substance addiction. | Changeux JP et al. | β | 2011 | β |
| Endogenously expressed muscarinic receptors in HEK293 cells augment up-regulation of stably expressed Ξ±4Ξ²2 nicotinic receptors. | Hussmann GP et al. | β | 2011 | β |
| Identification of a negative allosteric site on human Ξ±4Ξ²2 and Ξ±3Ξ²4 neuronal nicotinic acetylcholine receptors. | Pavlovicz RE et al. | β | 2011 | β |
| Inactivity-induced increase in nAChRs upregulates Shal K(+) channels to stabilize synaptic potentials. | Ping Y et al. | β | 2011 | β |
| Interaction of bupropion and zinc with neuronal nicotinic acetylcholine receptors. | GarcΓa-Colunga J et al. | β | 2011 | β |
| Mechanistic insights into nicotine withdrawal. | Paolini M et al. | β | 2011 | β |
| Mutant human Ξ²4 subunit identified in amyotrophic lateral sclerosis patients impairs nicotinic receptor function. | Moriconi C et al. | β | 2011 | β |
| Nicotine and endogenous opioids: neurochemical and pharmacological evidence. | Hadjiconstantinou M et al. | β | 2011 | β |
| Nicotinergic impact on focal and non-focal neuroplasticity induced by non-invasive brain stimulation in non-smoking humans. | Thirugnanasambandam N et al. | β | 2011 | β |
| Nicotinic acetylcholine receptor ligands, a patent review (2006-2011). | GΓΌndisch D et al. | β | 2011 | β |
| Nicotinic receptor agonists decrease L-dopa-induced dyskinesias most effectively in partially lesioned parkinsonian rats. | Huang LZ et al. | β | 2011 | β |
| Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations. | Williams DK et al. | β | 2011 | β |
| Pre-clinical validation of a novel alpha-7 nicotinic receptor radiotracer, [(3)H]AZ11637326: target localization, biodistribution and ligand occupancy in the rat brain. | Maier DL et al. | β | 2011 | β |
| Presynaptic nicotinic Ξ±7 and non-Ξ±7 receptors stimulate endogenous GABA release from rat hippocampal synaptosomes through two mechanisms of action. | Zappettini S et al. | β | 2011 | β |
| Progress and challenges in the study of Ξ±6-containing nicotinic acetylcholine receptors. | Letchworth SR et al. | β | 2011 | β |
| Recent advances in gene manipulation and nicotinic acetylcholine receptor biology. | TammimΓ€ki A et al. | β | 2011 | β |
| Resistance of male Sprague-Dawley rats to sucrose-induced obesity: effects of 18-methoxycoronaridine. | Taraschenko OD et al. | β | 2011 | β |
| Role of Ξ±6 nicotinic receptors in CNS dopaminergic function: relevance to addiction and neurological disorders. | Quik M et al. | β | 2011 | β |
| Selective nicotinic receptor antagonists: effects on attention and nicotine-induced attentional enhancement. | Hahn B et al. | β | 2011 | β |
| Structure-activity studies of diazabicyclo[3.3.0]octane-substituted pyrazines and pyridines as potent Ξ±4Ξ²2 nicotinic acetylcholine receptor ligands. | Scanio MJ et al. | β | 2011 | β |
| Targeting nicotinic receptors for Parkinson's disease therapy. | Quik M et al. | β | 2011 | β |
| The effects of aging vs. Ξ±7 nAChR subunit deficiency on the mouse brain transcriptome: aging beats the deficiency. | Kedmi M et al. | β | 2011 | β |
| The effects of galantamine on nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6 mice. | Wilkinson DS et al. | β | 2011 | β |
| The necessity of Ξ±4* nicotinic receptors in nicotine-driven behaviors: dissociation between reinforcing and motor effects of nicotine. | Cahir E et al. | β | 2011 | β |
| Unichiral 2-(2'-pyrrolidinyl)-1,4-benzodioxanes: the 2R,2'S diastereomer of the N-methyl-7-hydroxy analogue is a potent Ξ±4Ξ²2- and Ξ±6Ξ²2-nicotinic acetylcholine receptor partial agonist. | Bolchi C et al. | β | 2011 | β |
| Zebrafish for the study of the biological effects of nicotine. | Klee EW et al. | β | 2011 | β |
| A comparative study of the effects of the intravenous self-administration or subcutaneous minipump infusion of nicotine on the expression of brain neuronal nicotinic receptor subtypes. | Moretti M et al. | β | 2010 | β |
| Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as Ξ±4Ξ²2-nicotinic acetylcholine receptor-selective partial agonists. | Liu J et al. | β | 2010 | β |
| Cortico-thalamic connectivity is vulnerable to nicotine exposure during early postnatal development through Ξ±4/Ξ²2/Ξ±5 nicotinic acetylcholine receptors. | Heath CJ et al. | β | 2010 | β |
| Early exposure to nicotine during critical periods of brain development: Mechanisms and consequences. | Smith AM et al. | β | 2010 | β |
| Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs? | Markus RP et al. | β | 2010 | β |
| Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders. | Chatterjee S et al. | β | 2010 | β |
| Nicotine addiction and nicotinic receptors: lessons from genetically modified mice. | Changeux JP | β | 2010 | β |
| Nicotinic acetylcholine receptors in the mesolimbic pathway: primary role of ventral tegmental area alpha6beta2* receptors in mediating systemic nicotine effects on dopamine release, locomotion, and reinforcement. | Gotti C et al. | β | 2010 | β |
| Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitization. | Bordia T et al. | β | 2010 | β |
| Novel Ξ±3Ξ²4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. | Zaveri N et al. | β | 2010 | β |
| The nicotinic acetylcholine receptor alpha5 subunit plays a key role in attention circuitry and accuracy. | Bailey CD et al. | β | 2010 | β |
| Varenicline in smoking cessation. | Tonstad S et al. | β | 2010 | β |
| Ξ±6Γ2* and Ξ±4Γ2* nicotinic receptors both regulate dopamine signaling with increased nigrostriatal damage: relevance to Parkinson's disease. | Perez XA et al. | β | 2010 | β |
| Ξ±-Conotoxin BuIA[T5A;P6O]: a novel ligand that discriminates between Ξ±6Γ4 and Ξ±6Γ2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release. | Azam L et al. | β | 2010 | β |