Critical factors in gene expression in postmortem human brain: Focus on studies in schizophrenia.
paper
Cited
Public
Unavailable
- Authors
- Lipska, Barbara K; Deep-Soboslay, Amy; Weickert, Cynthia Shannon; Hyde, Thomas M; Martin, Catherine E; Herman, Mary M; Kleinman, Joel E
- Year
- 2006
- Journal
- Biological psychiatry
- PMID
- 16997002
- DOI
- 10.1016/j.biopsych.2006.06.019
BACKGROUND: Studies of postmortem human brain are important for investigating underlying pathogenic molecular mechanisms of neuropsychiatric disorders. They are, however, confounded by pre- and postmortem factors. The purpose of this study was to identify sources of variation that will enable a better design of gene expression studies and higher reliability of gene expression data. METHODS: We assessed the contribution of multiple variables to messenger RNA (mRNA) expression of reference (housekeeping) genes measured by reverse transcriptase-polymerase chain reaction (RT-PCR) by multiple regression analysis in a large number (N = 143) of autopsy samples from the hippocampus and white and grey matter of the dorsolateral prefrontal cortex (DLPFC) of patients with schizophrenia and normal control subjects. RESULTS: The strongest predictor of gene expression was total RNA quality. Other significant factors included pH, postmortem interval, age and the duration of the agonal state, but the importance of these factors depended on transcript measured, brain region analyzed, and diagnosis. The quality of RNA obtained from the DLPFC white matter was also adversely affected by smoking. CONCLUSIONS: Our results show that normalization of expression data of target genes with a geometric mean of multiple housekeeping genes should be used to control for differences in RNA quality between samples. The results also suggest that accurate assessment of other confounding factors and their inclusion as regressors in the analysis is critical for obtaining reliable and accurate quantification of mRNA expression.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Associations Between Fatty Acid Levels in Human Blood and Trigeminovascular Tissues. | Zamora D et al. | β | 2026 | β |
| Postmortem tissue biomarkers of menopausal transition. | Tickerhoof M et al. | β | 2026 | β |
| Spatially resolved molecular sex differences at single-cell resolution in the adult human ventromedial and arcuate hypothalamus. | Mulvey B et al. | β | 2026 | β |
| A hexamer tandem repeat RNA embedded within an SVA retrotransposon drives R-loop formation and neurodegeneration. | D'Ignazio L et al. | β | 2025 | β |
| An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus. | Thompson JR et al. | β | 2025 | β |
| Brain transcriptomic signatures for mood disorders and suicide phenotypes: an anterior insula and subgenual ACC network postmortem study. | Arasappan D et al. | β | 2025 | β |
| Effects of disease severity on RNA integrity measures in necrotising soft tissue infection as a possible source of research bias: An observational cohort study. | Vinkel J et al. | β | 2025 | β |
| Efficient removal of naturally-occurring lipofuscin autofluorescence in human nervous tissue using high-intensity white light. | Sapio MR et al. | β | 2025 | β |
| Impact of Confounding Factors in Human Postmortem Brain Tissues on Gene Expression Profiles: A Comparison of Patients With Schizophrenia, Bipolar Disorder, and Nonpsychiatric Controls. | Hatano M et al. | β | 2025 | β |
| lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression. | Maden SK et al. | β | 2025 | β |
| Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward. | Brida KL et al. | β | 2025 | β |
| Spatiotemporal analysis of gene expression in the human dentate gyrus reveals age-associated changes in cellular maturation and neuroinflammation. | Ramnauth AD et al. | β | 2025 | β |
| Transcriptomic Analysis of the Human Habenula in Schizophrenia. | Yalcinbas EA et al. | β | 2025 | β |
| Transcriptomic characterization of human lateral septum neurons reveals conserved and divergent marker genes across species. | Phillips RA et al. | β | 2025 | β |
| Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates. | Totty MS et al. | β | 2025 | β |
| When the Stars Misfire: Astrocytic Dysfunctions in Major Depressive Disorder. | GonzΓ‘lez-Arias C et al. | β | 2025 | β |
| A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex. | Huuki-Myers LA et al. | β | 2024 | β |
| Alcohol Use Disorder-Associated DNA Methylation in the Nucleus Accumbens and Dorsolateral Prefrontal Cortex. | White JD et al. | β | 2024 | β |
| Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders. | Luo J et al. | β | 2024 | β |
| Identification of a specific APOE transcript and functional elements associated with Alzheimer's disease. | Chen Q et al. | β | 2024 | β |
| Integrating gene expression and imaging data across Visium capture areas with visiumStitched. | Eagles NJ et al. | β | 2024 | β |
| Modeling common and rare genetic risk factors of neuropsychiatric disorders in human induced pluripotent stem cells. | Muhtaseb AW et al. | β | 2024 | β |
| Schizophrenia risk-associated SNPs affect expression of microRNA 137 host gene: a postmortem study. | Feng N et al. | β | 2024 | β |
| The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics. | Weber LM et al. | β | 2024 | β |
| Use of Post-mortem Brain Tissue in Investigations of Obsessive- Compulsive Disorder: A Systematic Review. | Lochner C et al. | β | 2024 | β |
| Cellular Diversity in Human Subgenual Anterior Cingulate and Dorsolateral Prefrontal Cortex by Single-Nucleus RNA-Sequencing. | Kim B et al. | β | 2023 | β |
| Challenges and opportunities to computationally deconvolve heterogeneous tissue with varying cell sizes using single-cell RNA-sequencing datasets. | Maden SK et al. | β | 2023 | β |
| Consistency and Variation in Doublecortin and Ki67 Antigen Detection in the Brain Tissue of Different Mammals, including Humans. | Ghibaudi M et al. | β | 2023 | β |
| Data-driven identification of total RNA expression genes for estimation of RNA abundance in heterogeneous cell types highlighted in brain tissue. | Huuki-Myers LA et al. | β | 2023 | β |
| Influence of Alzheimer's disease related neuropathology on local microenvironment gene expression in the human inferior temporal cortex. | Kwon SH et al. | β | 2023 | β |
| <i>VistoSeg</i>: Processing utilities for high-resolution images for spatially resolved transcriptomics data. | Tippani M et al. | β | 2023 | β |
| Orthogonal approaches required to measure proteasome composition and activity in mammalian brain tissue. | TΓΌrker F et al. | β | 2023 | β |
| Polygenic scores for psychiatric disorders in a diverse postmortem brain tissue cohort. | Duncan L et al. | β | 2023 | β |
| Region-Specific Transcriptional Signatures of Brain Aging in the Absence of Neuropathology at the Single-cell Level | Mesecar ME et al. | β | 2023 | β |
| Relationships between neurotransmitter receptor densities and expression levels of their corresponding genes in the human hippocampus. | Zhao L et al. | β | 2023 | β |
| SUFI: an automated approach to spectral unmixing of fluorescent multiplex images captured in mouse and post-mortem human brain tissues. | Sadashivaiah V et al. | β | 2023 | β |
| The influence of tissue pH and RNA integrity number on gene expression of human postmortem brain. | Miyahara K et al. | β | 2023 | β |
| The miR-124-AMPAR pathway connects polygenic risks with behavioral changes shared between schizophrenia and bipolar disorder. | Namkung H et al. | β | 2023 | β |
| Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways. | Zandi PP et al. | β | 2022 | β |
| Analysis of the caudate nucleus transcriptome in individuals with schizophrenia highlights effects of antipsychotics and new risk genes. | Benjamin KJM et al. | β | 2022 | β |
| Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders. | Sadeghi I et al. | β | 2022 | β |
| Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders. | Zhou J et al. | β | 2022 | β |
| Genetics and Brain Transcriptomics of Completed Suicide. | Punzi G et al. | β | 2022 | β |
| Immune-Related Genomic Schizophrenic Subtyping Identified in DLPFC Transcriptome. | Childers E et al. | β | 2022 | β |
| MCP-1/CCR2 axis inhibition sensitizes the brain microenvironment against melanoma brain metastasis progression. | Pozzi S et al. | β | 2022 | β |
| The role of mitochondria in the pathophysiology of schizophrenia: A critical review of the evidence focusing on mitochondrial complex one. | Whitehurst T et al. | β | 2022 | β |
| Variation in TAF1 Expression in Female Carrier-Induced Pluripotent Stem Cells and Human Brain Ontogeny Has Implications for Adult Neostriatum Vulnerability in X-Linked Dystonia Parkinsonism. | D'Ignazio L et al. | β | 2022 | β |
| Cortical expression of the RAPGEF1 gene in schizophrenia: investigating regional differences and suicide. | Gogos A et al. | β | 2021 | β |
| Developmental Profile of Psychiatric Risk Associated With Voltage-Gated Cation Channel Activity. | Clifton NE et al. | β | 2021 | β |
| Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk. | Perzel Mandell KA et al. | β | 2021 | β |
| Network modules linking expression and methylation in prefrontal cortex of schizophrenia. | Lin D et al. | β | 2021 | β |
| P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression. | Yeini E et al. | β | 2021 | β |
| Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain. | Tran MN et al. | β | 2021 | β |
| Transcription Factor Motifs Associated with Anterior Insula Gene Expression Underlying Mood Disorder Phenotypes. | Arasappan D et al. | β | 2021 | β |
| Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex. | Maynard KR et al. | β | 2021 | β |
| Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia. | Tao R et al. | β | 2020 | β |
| Characterizing the nuclear and cytoplasmic transcriptomes in developing and mature human cortex uncovers new insight into psychiatric disease gene regulation. | Price AJ et al. | β | 2020 | β |
| dotdotdot: an automated approach to quantify multiplex single molecule fluorescent in situ hybridization (smFISH) images in complex tissues. | Maynard KR et al. | β | 2020 | β |
| Neuro-transcriptomic signatures for mood disorder morbidity and suicide mortality. | Jabbi M et al. | β | 2020 | β |
| Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk. | Jaffe AE et al. | β | 2020 | β |
| Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19). | Ma L et al. | β | 2020 | β |
| Association of a Noncoding RNA Postmortem With Suicide by Violent Means and InΒ Vivo With Aggressive Phenotypes. | Punzi G et al. | β | 2019 | β |
| Astrocyte, a Promising Target for Mood Disorder Interventions. | Zhou X et al. | β | 2019 | β |
| Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia. | Meiklejohn H et al. | β | 2019 | β |
| Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation. | Price AJ et al. | β | 2019 | β |
| DLPFC transcriptome defines two molecular subtypes of schizophrenia. | Bowen EFW et al. | β | 2019 | β |
| From Schizophrenia Genetics to Disease Biology: Harnessing New Concepts and Technologies. | Duan J et al. | β | 2019 | β |
| Increased Protein Insolubility in Brains From a Subset of Patients With Schizophrenia. | Nucifora LG et al. | β | 2019 | β |
| Integrated Analysis of Brain Transcriptome Reveals Convergent Molecular Pathways in Autism Spectrum Disorder. | Li X et al. | β | 2019 | β |
| Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease. | Semick SA et al. | β | 2019 | β |
| Postmortem brain tissue as an underutilized resource to study the molecular pathology of neuropsychiatric disorders across different ethnic populations. | Vornholt E et al. | β | 2019 | β |
| Rate of brain aging and <i>APOE Ξ΅4</i> are synergistic risk factors for Alzheimer's disease. | Glorioso CA et al. | β | 2019 | β |
| Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia. | Collado-Torres L et al. | β | 2019 | β |
| Technical considerations in detection of HERV-K in amyotrophic lateral sclerosis: selection of controls and the perils of qPCR. | Garcia-Montojo M et al. | β | 2019 | β |
| The effect of body mass index on glucagon-like peptide receptor gene expression in the post mortem brain from individuals with mood and psychotic disorders. | Mansur RB et al. | β | 2019 | β |
| Ξ-actin does not show the characteristics of a reference protein in human cortex. | Parkin GM et al. | β | 2019 | β |
| Cell-Specific RNA Quantification in Human SN DA Neurons from Heterogeneous Post-mortem Midbrain Samples by UV-Laser Microdissection and RT-qPCR. | Duda J et al. | β | 2018 | β |
| Changed frontal pole gene expression suggest altered interplay between neurotransmitter, developmental, and inflammatory pathways in schizophrenia. | Scarr E et al. | β | 2018 | β |
| Considerations for optimal use of postmortem human brains for molecular psychiatry: lessons from schizophrenia. | Weickert CS et al. | β | 2018 | β |
| Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders. | Hagihara H et al. | β | 2018 | β |
| Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis. | Jaffe AE et al. | β | 2018 | β |
| DNA methylation age is not accelerated in brain or blood of subjects with schizophrenia. | McKinney BC et al. | β | 2018 | β |
| Effect of Postmortem Interval and Years in Storage on RNA Quality of Tissue at a Repository of the NIH NeuroBioBank. | White K et al. | β | 2018 | β |
| Effects on gene expression and behavior of untagged short tandem repeats: the case of arginine vasopressin receptor 1a (AVPR1a) and externalizing behaviors. | Landefeld CC et al. | β | 2018 | β |
| Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes. | Mansur RB et al. | β | 2018 | β |
| Genetic risk mechanisms of posttraumatic stress disorder in the human brain. | Bharadwaj RA et al. | β | 2018 | β |
| Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia. | Boks MP et al. | β | 2018 | β |
| High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development. | Hefti MM et al. | β | 2018 | β |
| Investigating the neuroimmunogenic architecture of schizophrenia. | Birnbaum R et al. | β | 2018 | β |
| Laser microdissection and gene expression profiling in the human postmortem brain. | Sonntag KC et al. | β | 2018 | β |
| Neuronal life after death: electrophysiologic recordings from neurons in adult human brain tissue obtained through surgical resection or postmortem. | Kramvis I et al. | β | 2018 | β |
| Overexpression of LINE-1 Retrotransposons in Autism Brain. | Shpyleva S et al. | β | 2018 | β |
| Oxytocin receptor mRNA expression in dorsolateral prefrontal cortex in major psychiatric disorders: A human post-mortem study. | Lee MR et al. | β | 2018 | β |
| Altered expression of histamine signaling genes in autism spectrum disorder. | Wright C et al. | β | 2017 | β |
| Association of functional genetic variation in PP2A with prefrontal working memory processing. | Rampino A et al. | β | 2017 | β |
| A Study of TNF Pathway Activation in Schizophrenia and Bipolar Disorder in Plasma and Brain Tissue. | Hoseth EZ et al. | β | 2017 | β |
| Deficits in the activity of presynaptic Ξ³-aminobutyric acid type B receptors contribute to altered neuronal excitability in fragile X syndrome. | Kang JY et al. | β | 2017 | β |
| Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia. | Schroeder FA et al. | β | 2017 | β |
| Gene expression profiling in the human alcoholic brain. | Warden AS et al. | β | 2017 | β |
| Mechanism and properties of positive allosteric modulation of N-methyl-d-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives. | Sapkota K et al. | β | 2017 | β |
| Open Chromatin Profiling in hiPSC-Derived Neurons Prioritizes Functional Noncoding Psychiatric Risk Variants and Highlights Neurodevelopmental Loci. | Forrest MP et al. | β | 2017 | β |
| Postsynaptic Density-95 Isoform Abnormalities in Schizophrenia. | Funk AJ et al. | β | 2017 | β |
| Putative presynaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain. | Purves-Tyson TD et al. | β | 2017 | β |
| Residues in the GluN1 C-terminal domain control kinetics and pharmacology of GluN1/GluN3A N-methyl-d-aspartate receptors. | Cummings KA et al. | β | 2017 | β |
| Spatial and temporal expression patterns of genes around nine neuroticism-associated loci. | Ohi K et al. | β | 2017 | β |
| The impact of genetics on future drug discovery in schizophrenia. | Matsumoto M et al. | β | 2017 | β |
| A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus. | Li M et al. | β | 2016 | β |
| Assessment of genetic risk for distribution of total interstitial white matter neurons in dorsolateral prefrontal cortex: role in schizophrenia. | McFadden WC et al. | β | 2016 | β |
| Complex Sources of Variation in Tissue Expression Data: Analysis of the GTEx Lung Transcriptome. | McCall MN et al. | β | 2016 | β |
| GAD2 Alternative Transcripts in the Human Prefrontal Cortex, and in Schizophrenia and Affective Disorders. | Davis KN et al. | β | 2016 | β |
| Genomic structure and expression of the human serotonin 2A receptor gene (HTR2A) locus: identification of novel HTR2A and antisense (HTR2A-AS1) exons. | Ruble CL et al. | β | 2016 | β |
| Increased cortical expression of the zinc transporter SLC39A12 suggests a breakdown in zinc cellular homeostasis as part of the pathophysiology of schizophrenia. | Scarr E et al. | β | 2016 | β |
| KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex. | Johnson EO et al. | β | 2016 | β |
| Limited predictability of postmortem human brain tissue quality by RNA integrity numbers. | Sonntag KC et al. | β | 2016 | β |
| Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex. | Jaffe AE et al. | β | 2016 | β |
| Metabotropic glutamate receptor 3 (mGlu3; mGluR3; GRM3) in schizophrenia: Antibody characterisation and a semi-quantitative western blot study. | GarcΓa-Bea A et al. | β | 2016 | β |
| Protons Potentiate GluN1/GluN3A Currents by Attenuating Their Desensitisation. | Cummings KA et al. | β | 2016 | β |
| Validating reference genes using minimally transformed qpcr data: findings in human cortex and outcomes in schizophrenia. | Dean B et al. | β | 2016 | β |
| A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. | Hancock DB et al. | β | 2015 | β |
| CHRNA7 and CHRFAM7A mRNAs: co-localized and their expression levels altered in the postmortem dorsolateral prefrontal cortex in major psychiatric disorders. | Kunii Y et al. | β | 2015 | β |
| Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1. | Hancock DB et al. | β | 2015 | β |
| Developmental regulation of human cortex transcription and its clinical relevance at single base resolution. | Jaffe AE et al. | β | 2015 | β |
| Human Obesity Associated with an Intronic SNP in the Brain-Derived Neurotrophic Factor Locus. | Mou Z et al. | β | 2015 | β |
| Path from schizophrenia genomics to biology: gene regulation and perturbation in neurons derived from induced pluripotent stem cells and genome editing. | Duan J | β | 2015 | β |
| Sex differences in glutamate receptor gene expression in major depression and suicide. | Gray AL et al. | β | 2015 | β |
| Systematic noise degrades gene co-expression signals but can be corrected. | Freytag S et al. | β | 2015 | β |
| Characteristics of the cation cotransporter NKCC1 in human brain: alternate transcripts, expression in development, and potential relationships to brain function and schizophrenia. | Morita Y et al. | β | 2014 | β |
| Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain. | Kaalund SS et al. | β | 2014 | β |
| DNA methylation changes in the postmortem dorsolateral prefrontal cortex of patients with schizophrenia. | Numata S et al. | β | 2014 | β |
| Effects of schizophrenia risk variation in the NRG1 gene on NRG1-IV splicing during fetal and early postnatal human neocortical development. | Paterson C et al. | β | 2014 | β |
| Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706. | Tao R et al. | β | 2014 | β |
| Genetic neuropathology of obsessive psychiatric syndromes. | Jaffe AE et al. | β | 2014 | β |
| Postmortem brain: an underutilized substrate for studying severe mental illness. | McCullumsmith RE et al. | β | 2014 | β |
| Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression. | Kunii Y et al. | β | 2014 | β |
| RNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms and GTPase binding in bipolar disorder. | Akula N et al. | β | 2014 | β |
| The SORL1 gene and convergent neural risk for Alzheimer's disease across the human lifespan. | Felsky D et al. | β | 2014 | β |
| ABCA8 stimulates sphingomyelin production in oligodendrocytes. | Kim WS et al. | β | 2013 | β |
| A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflammation. | Kreisl WC et al. | β | 2013 | β |
| Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy. | Morgan RA et al. | β | 2013 | β |
| Different changes in cortical tumor necrosis factor-Ξ±-related pathways in schizophrenia and mood disorders. | Dean B et al. | β | 2013 | β |
| Differential effect of lithium on spermidine/spermine N1-acetyltransferase expression in suicidal behaviour. | Squassina A et al. | β | 2013 | β |
| Increases in two truncated TrkB isoforms in the prefrontal cortex of people with schizophrenia. | Wong J et al. | β | 2013 | β |
| Microstructural grey matter parcellation and its relevance for connectome analyses. | Caspers S et al. | β | 2013 | β |
| Pharmacogenomics of bipolar disorder. | Severino G et al. | β | 2013 | β |
| Analysis of copy number variations in brain DNA from patients with schizophrenia and other psychiatric disorders. | Ye T et al. | β | 2012 | β |
| Association of ApoE and LRP mRNA levels with dementia and AD neuropathology. | Akram A et al. | β | 2012 | β |
| Binding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophrenia. | Jenko KJ et al. | β | 2012 | β |
| Defective dentate nucleus GABA receptors in essential tremor. | Paris-Robidas S et al. | β | 2012 | β |
| DNA methylation signatures in development and aging of the human prefrontal cortex. | Numata S et al. | β | 2012 | β |
| Expression pattern of the cannabinoid receptor genes in the frontal cortex ofΒ mood disorder patients and mice selectively bred for high and low fear. | Choi K et al. | β | 2012 | β |
| Gender-specific reduction of estrogen-sensitive small RNA, miR-30b, in subjects with schizophrenia. | Mellios N et al. | β | 2012 | β |
| Gene expression profiling and therapeutic interventions in neurodegenerative diseases: a comprehensive study on potentiality and limits. | Benetti F et al. | β | 2012 | β |
| Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures. | Zeng H et al. | β | 2012 | β |
| Reduced myelin basic protein and actin-related gene expression in visual cortex in schizophrenia. | Matthews PR et al. | β | 2012 | β |
| RNA quality assessment: a view from plant qPCR studies. | Die JV et al. | β | 2012 | β |
| Transcript-specific associations of SLC12A5 (KCC2) in human prefrontal cortex with development, schizophrenia, and affective disorders. | Tao R et al. | β | 2012 | β |
| Use of postmortem human dura mater and scalp for deriving human fibroblast cultures. | Bliss LA et al. | β | 2012 | β |
| Using genome-wide expression profiling to define gene networks relevant to the study of complex traits: from RNA integrity to network topology. | O'Brien MA et al. | β | 2012 | β |
| Aberrant NF-kappaB expression in autism spectrum condition: a mechanism for neuroinflammation. | Young AM et al. | β | 2011 | β |
| Changed relative to what? Housekeeping genes and normalization strategies in human brain gene expression studies. | Tunbridge EM et al. | β | 2011 | β |
| Development of patient-specific neurons in schizophrenia using induced pluripotent stem cells. | Pedrosa E et al. | β | 2011 | β |
| Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes. | Wonodi I et al. | β | 2011 | β |
| Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia. | Hyde TM et al. | β | 2011 | β |
| Genetic neuropathology of schizophrenia: new approaches to an old question and new uses for postmortem human brains. | Kleinman JE et al. | β | 2011 | β |
| Interactions of human truncated DISC1 proteins: implications for schizophrenia. | Newburn EN et al. | β | 2011 | β |
| Novel approaches to the study of postmortem brain in psychiatric illness: old limitations and new challenges. | McCullumsmith RE et al. | β | 2011 | β |
| Psychiatric brain banking: three perspectives on current trends and future directions. | Deep-Soboslay A et al. | β | 2011 | β |
| RNA integrity in post mortem human variant Creutzfeldt-Jakob disease (vCJD) and control brain tissue. | Sherwood KR et al. | β | 2011 | β |
| RNA-Seq of human neurons derived from iPS cells reveals candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders. | Lin M et al. | β | 2011 | β |
| RT-qPCR study on post-mortem brain samples from patients with major psychiatric disorders: reference genes and specimen characteristics. | Abasolo N et al. | β | 2011 | β |
| Temporal dynamics and genetic control of transcription in the human prefrontal cortex. | Colantuoni C et al. | β | 2011 | β |
| Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia. | Yuan P et al. | β | 2010 | β |
| Analysis of whole genome biomarker expression in blood and brain. | Rollins B et al. | β | 2010 | β |
| Blood mononuclear cell gene expression signature of postpartum depression. | Segman RH et al. | β | 2010 | β |
| Effects of antemortem and postmortem variables on human brain mRNA quality: a BrainNet Europe study. | Durrenberger PF et al. | β | 2010 | β |
| Gene expression of neuregulin-1 isoforms in different brain regions of elderly schizophrenia patients. | Parlapani E et al. | β | 2010 | β |
| Genetic variation in FGF20 modulates hippocampal biology. | Lemaitre H et al. | β | 2010 | β |
| Human brain weight is correlated with expression of the 'housekeeping genes' beta-2-microglobulin (Ξ²2M) and TATA-binding protein (TBP). | Harrison PJ et al. | β | 2010 | β |
| Increased expression of cholesterol transporter ABCA1 is highly correlated with severity of dementia in AD hippocampus. | Akram A et al. | β | 2010 | β |
| Increased expression of RXRΞ± in dementia: an early harbinger for the cholesterol dyshomeostasis? | Akram A et al. | β | 2010 | β |
| Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder. | Eastwood SL et al. | β | 2010 | β |
| N-methyl-D-aspartate receptor expression in parvalbumin-containing inhibitory neurons in the prefrontal cortex in bipolar disorder. | Bitanihirwe BK et al. | β | 2010 | β |
| Promoter specific alterations of brain-derived neurotrophic factor mRNA in schizophrenia. | Wong J et al. | β | 2010 | β |
| RPP25 is developmentally regulated in prefrontal cortex and expressed at decreased levels in autism spectrum disorder. | Huang HS et al. | β | 2010 | β |
| Selection of reference gene expression in a schizophrenia brain cohort. | Weickert CS et al. | β | 2010 | β |
| A comparison of human brain dissection by drill versus saw on nucleic acid quality. | Buerlein RC et al. | β | 2009 | β |
| Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function. | Maycox PR et al. | β | 2009 | β |
| Apolipoprotein-D expression is increased during development and maturation of the human prefrontal cortex. | Kim WS et al. | β | 2009 | β |
| Changes in alternative brain-derived neurotrophic factor transcript expression in the developing human prefrontal cortex. | Wong J et al. | β | 2009 | β |
| Detection of stable reference genes for real-time PCR analysis in schizophrenia and bipolar disorder. | Silberberg G et al. | β | 2009 | β |
| DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. | Nakata K et al. | β | 2009 | β |
| Dopamine transporter polymorphism modulates oculomotor function and DAT1 mRNA expression in schizophrenia. | Wonodi I et al. | β | 2009 | β |
| Expression of kinase interacting with stathmin (KIS, UHMK1) in human brain and lymphoblasts: Effects of schizophrenia and genotype. | Bristow GC et al. | β | 2009 | β |
| Expression profiles of schizophrenia susceptibility genes during human prefrontal cortical development. | Choi KH et al. | β | 2009 | β |
| Functional and anatomical connectivity abnormalities in left inferior frontal gyrus in schizophrenia. | Jeong B et al. | β | 2009 | β |
| Identification of brain transcriptional variation reproduced in peripheral blood: an approach for mapping brain expression traits. | Jasinska AJ et al. | β | 2009 | β |
| Improved RNA preservation for immunolabeling and laser microdissection. | Brown AL et al. | β | 2009 | β |
| Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia. | Mellios N et al. | β | 2009 | β |
| The importance of brain banks for molecular neuropathological research: The New South Wales Tissue Resource Centre experience. | Dedova I et al. | β | 2009 | β |
| Twenty-one-base-pair insertion polymorphism creates an enhancer element and potentiates SLC6A1 GABA transporter promoter activity. | Hirunsatit R et al. | β | 2009 | β |
| Assessing RNA quality in postmortem human brain tissue. | Chevyreva Ia et al. | β | 2008 | β |
| Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. | Hashimoto T et al. | β | 2008 | β |
| Decreased mRNA expression of netrin-G1 and netrin-G2 in the temporal lobe in schizophrenia and bipolar disorder. | Eastwood SL et al. | β | 2008 | β |
| Effect of RNA quality on transcript intensity levels in microarray analysis of human post-mortem brain tissues. | Popova T et al. | β | 2008 | β |
| Evaluation of tissue collection for postmortem studies of bipolar disorder. | Deep-Soboslay A et al. | β | 2008 | β |
| Expression of a GRM3 splice variant is increased in the dorsolateral prefrontal cortex of individuals carrying a schizophrenia risk SNP. | Sartorius LJ et al. | β | 2008 | β |
| Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia. | Mitkus SN et al. | β | 2008 | β |
| Identification of valid reference genes for the normalization of RT qPCR gene expression data in human brain tissue. | Coulson DT et al. | β | 2008 | β |
| Increased lactate levels and reduced pH in postmortem brains of schizophrenics: medication confounds. | Halim ND et al. | β | 2008 | β |
| Isolation of neuronal chromatin from brain tissue. | Jiang Y et al. | β | 2008 | β |
| Putative psychosis genes in the prefrontal cortex: combined analysis of gene expression microarrays. | Choi KH et al. | β | 2008 | β |
| Specific developmental reductions in subventricular zone ErbB1 and ErbB4 mRNA in the human brain. | Chong VZ et al. | β | 2008 | β |
| The utility of SELENBP1 gene expression as a biomarker for major psychotic disorders: replication in schizophrenia and extension to bipolar disorder with psychosis. | Kanazawa T et al. | β | 2008 | β |
| Transcriptional correlates of human substance use. | Lehrmann E et al. | β | 2008 | β |
| Variants in the estrogen receptor alpha gene and its mRNA contribute to risk for schizophrenia. | Weickert CS et al. | β | 2008 | β |
| Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression. | Straub RE et al. | β | 2007 | β |
| Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1. | Mathew SV et al. | β | 2007 | β |
| Autism brain tissue banking. | Haroutunian V et al. | β | 2007 | β |
| DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. | Siegmund KD et al. | β | 2007 | β |
| Genetic evidence implicating DARPP-32 in human frontostriatal structure, function, and cognition. | Meyer-Lindenberg A et al. | β | 2007 | β |
| Methodological considerations for gene expression profiling of human brain. | Atz M et al. | β | 2007 | β |
| Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. | Huang HS et al. | β | 2007 | β |
| Quality control for microarray analysis of human brain samples: The impact of postmortem factors, RNA characteristics, and histopathology. | Weis S et al. | β | 2007 | β |
| Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. | Lehrmann E et al. | β | 2006 | β |
| New insights into the role of thyroid hormone in the CNS: the microglial track. | Mallat M et al. | β | 2002 | β |