Imaging dopamine's role in drug abuse and addiction.
paper
Cited
Public
Unavailable
- Authors
- Volkow, N D; Fowler, J S; Wang, G J; Baler, R; Telang, F
- Year
- 2009
- Journal
- Neuropharmacology
- PMID
- 18617195
- DOI
- 10.1016/j.neuropharm.2008.05.022
- PMCID
- PMC2696819
Dopamine is involved in drug reinforcement but its role in addiction is less clear. Here we describe PET imaging studies that investigate dopamine's involvement in drug abuse in the human brain. In humans the reinforcing effects of drugs are associated with large and fast increases in extracellular dopamine, which mimic those induced by physiological dopamine cell firing but are more intense and protracted. Since dopamine cells fire in response to salient stimuli, supraphysiological activation by drugs is experienced as highly salient (driving attention, arousal, conditioned learning and motivation) and with repeated drug use may raise the thresholds required for dopamine cell activation and signaling. Indeed, imaging studies show that drug abusers have marked decreases in dopamine D2 receptors and in dopamine release. This decrease in dopamine function is associated with reduced regional activity in orbitofrontal cortex (involved in salience attribution; its disruption results in compulsive behaviors), cingulate gyrus (involved in inhibitory control; its disruption results in impulsivity) and dorsolateral prefrontal cortex (involved in executive function; its disruption results in impaired regulation of intentional actions). In parallel, conditioning triggered by drugs leads to enhanced dopamine signaling when exposed to conditioned cues, which then drives the motivation to procure the drug in part by activation of prefrontal and striatal regions. These findings implicate deficits in dopamine activity-inked with prefrontal and striatal deregulation-in the loss of control and compulsive drug intake that results when the addicted person takes the drugs or is exposed to conditioned cues. The decreased dopamine function in addicted individuals also reduces their sensitivity to natural reinforcers. Therapeutic interventions aimed at restoring brain dopaminergic tone and activity of cortical projection regions could improve prefrontal function, enhance inhibitory control and interfere with impulsivity and compulsive drug administration while helping to motivate the addicted person to engage in non-drug related behaviors.
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| Deletion of the type 2 metabotropic glutamate receptor increases heroin abuse vulnerability in transgenic rats. | Gao JT et al. | — | 2018 | → |
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| Dopamine-endocannabinoid interactions mediate spike-timing-dependent potentiation in the striatum. | Xu H et al. | — | 2018 | → |
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| High and low doses of cocaine intake are differentially regulated by dopamine D2 receptors in the ventral tegmental area and the nucleus accumbens. | Chen R et al. | — | 2018 | → |
| Human Abuse Potential of the New Opioid Analgesic Molecule NKTR-181 Compared with Oxycodone. | Webster L et al. | — | 2018 | → |
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| Pro-dopamine regulator, KB220Z, attenuates hoarding and shopping behavior in a female, diagnosed with SUD and ADHD. | McLaughlin T et al. | — | 2018 | → |
| Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder. | Bachi K et al. | — | 2018 | → |
| Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens. | Marcott PF et al. | — | 2018 | → |
| Resting State Functional Connectivity of the Lateral and Medial Hypothalamus in Cocaine Dependence: An Exploratory Study. | Zhang S et al. | — | 2018 | → |
| Role of Frontostriatal Connectivity in Adolescents With Excessive Smartphone Use. | Chun JW et al. | — | 2018 | → |
| Roux-en-Y gastric bypass surgery normalizes dopamine D1, D2, and DAT levels. | Hamilton J et al. | — | 2018 | → |
| Striatal dopamine D1-type receptor availability: no difference from control but association with cortical thickness in methamphetamine users. | Okita K et al. | — | 2018 | → |
| Structural and Functional Brain Connectivity Changes Between People With Abdominal and Non-abdominal Obesity and Their Association With Behaviors of Eating Disorders. | Park BY et al. | — | 2018 | → |
| Sugar addiction: is it real? A narrative review. | DiNicolantonio JJ et al. | — | 2018 | → |
| The Effect of Treatment with Guanfacine, an Alpha2 Adrenergic Agonist, on Dopaminergic Tone in Tobacco Smokers: An [<sup>11</sup>C]FLB457 PET Study. | Sandiego CM et al. | — | 2018 | → |
| The neural mechanisms and circuitry of the pair bond. | Walum H et al. | — | 2018 | → |
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| Transcranial magnetic stimulation for the treatment of cocaine addiction: evidence to date. | Bolloni C et al. | — | 2018 | → |
| Understanding the implications of the biobehavioral basis of nicotine addiction and its impact on the efficacy of treatment. | Bozinoff N et al. | — | 2018 | → |
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| Would induction of dopamine homeostasis via coupling genetic addiction risk score (GARS®) and pro-dopamine regulation benefit benzodiazepine use disorder (BUD)? | Blum K et al. | — | 2018 | → |
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| A single-scan protocol for absolute D<sub>2/3</sub> receptor quantification with [<sup>123</sup>I]IBZM SPECT. | Tsartsalis S et al. | — | 2017 | → |
| Caffeine Induces a Stimulant Effect and Increases Dopamine Release in the Nucleus Accumbens Shell Through the Pulmonary Inhalation Route of Administration in Rats. | Galvalisi M et al. | — | 2017 | → |
| Can cleanerfish overcome temptation? A selective role for dopamine influence on cooperative-based decision making. | Soares MC et al. | — | 2017 | → |
| Challenges in the development of therapeutics for narcolepsy. | Black SW et al. | — | 2017 | → |
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| Deletion of Type 2 Metabotropic Glutamate Receptor Decreases Sensitivity to Cocaine Reward in Rats. | Yang HJ et al. | — | 2017 | → |
| Dopamine D1 receptor agonist treatment attenuates extinction of morphine conditioned place preference while increasing dendritic complexity in the nucleus accumbens core. | Kobrin KL et al. | — | 2017 | → |
| Dopamine Increases CD14<sup>+</sup>CD16<sup>+</sup> Monocyte Transmigration across the Blood Brain Barrier: Implications for Substance Abuse and HIV Neuropathogenesis. | Calderon TM et al. | — | 2017 | → |
| Dopamine Receptors Differentially Control Binge Alcohol Drinking-Mediated Synaptic Plasticity of the Core Nucleus Accumbens Direct and Indirect Pathways. | Ji X et al. | — | 2017 | → |
| Drug abusers have impaired cerebral oxygenation and cognition during exercise. | Grandjean da Costa K et al. | — | 2017 | → |
| Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z. | Febo M et al. | — | 2017 | → |
| Exercise training reduces alcohol consumption but does not affect HPA-axis activity in heavy drinkers. | Georgakouli K et al. | — | 2017 | → |
| Functional expression of dopamine D2 receptor is regulated by tetraspanin 7-mediated postendocytic trafficking. | Lee SA et al. | — | 2017 | → |
| Glial and neuroinflammatory targets for treating substance use disorders. | Bachtell RK et al. | — | 2017 | → |
| Imaging Sex Differences in Regional Brain Metabolism during Acute Opioid Withdrawal. | Santoro GC et al. | — | 2017 | → |
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| Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats. | Du Y et al. | — | 2017 | → |
| Maternal impulse control disability and developmental disorder traits are risk factors for child maltreatment. | Tachibana Y et al. | — | 2017 | → |
| Measuring inhibition of monoamine reuptake transporters by new psychoactive substances (NPS) in real-time using a high-throughput, fluorescence-based assay. | Zwartsen A et al. | — | 2017 | → |
| New Insights Into the Roles of Retinoic Acid Signaling in Nervous System Development and the Establishment of Neurotransmitter Systems. | Zieger E et al. | — | 2017 | → |
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| The research domain criteria framework: The case for anterior cingulate cortex. | Holroyd CB et al. | — | 2016 | → |
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| Dopamine modulates hemocyte phagocytosis via a D1-like receptor in the rice stem borer, Chilo suppressalis. | Wu SF et al. | — | 2015 | → |
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| Morphine regulates Argonaute 2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons. | García-Pérez D et al. | — | 2015 | → |
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| Opposing role for Egr3 in nucleus accumbens cell subtypes in cocaine action. | Chandra R et al. | — | 2015 | → |
| Reduced insulin sensitivity is related to less endogenous dopamine at D2/3 receptors in the ventral striatum of healthy nonobese humans. | Caravaggio F et al. | — | 2015 | → |
| Resting state connectivity in alcohol dependent patients and the effect of repetitive transcranial magnetic stimulation. | Jansen JM et al. | — | 2015 | → |
| Selective inhibition of dopamine-beta-hydroxylase enhances dopamine release from noradrenergic terminals in the medial prefrontal cortex. | Devoto P et al. | — | 2015 | → |
| Smaller amygdala and medial prefrontal cortex predict escalating stimulant use. | Becker B et al. | — | 2015 | → |
| Striatal dopamine type 2 receptor availability in anorexia nervosa. | Broft A et al. | — | 2015 | → |
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| Synthesis and evaluation in rats of homologous series of [(18)F]-labeled dopamine D 2/3 receptor agonists based on the 2-aminomethylchroman scaffold as potential PET tracers. | Shalgunov V et al. | — | 2015 | → |
| Synthesis and evaluation in rats of the dopamine D2/3 receptor agonist 18F-AMC20 as a potential radioligand for PET. | Shalgunov V et al. | — | 2015 | → |
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| The brain disease model of addiction: is it supported by the evidence and has it delivered on its promises? | Hall W et al. | — | 2015 | → |
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| The role of prolactin in andrology: what is new? | Rastrelli G et al. | — | 2015 | → |
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| Alcohol challenge responses predict future alcohol use disorder symptoms: a 6-year prospective study. | King AC et al. | — | 2014 | → |
| Associations between childhood adversity, adult stressful life events, and past-year drug use disorders in the National Epidemiological Study of Alcohol and Related Conditions (NESARC). | Myers B et al. | — | 2014 | → |
| Baseline frontostriatal-limbic connectivity predicts reward-based memory formation. | Hamann JM et al. | — | 2014 | → |
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| Dissecting impulsivity and its relationships to drug addictions. | Jentsch JD et al. | — | 2014 | → |
| Does human presynaptic striatal dopamine function predict social conformity? | Stokes PR et al. | — | 2014 | → |
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| Dopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administration. | Yan Y et al. | — | 2014 | → |
| Dopamine D3 receptor is necessary for ethanol consumption: an approach with buspirone. | Leggio GM et al. | — | 2014 | → |
| Dopamine D3 receptor ligands for drug addiction treatment: update on recent findings. | Le Foll B et al. | — | 2014 | → |
| Dysfunctions of decision-making and cognitive control as transdiagnostic mechanisms of mental disorders: advances, gaps, and needs in current research. | Goschke T | — | 2014 | → |
| Effects of estrogen on higher-order cognitive functions in unstressed human females may depend on individual variation in dopamine baseline levels. | Colzato LS et al. | — | 2014 | → |
| Effects of genetic deletion of endogenous opioid system components on the reinstatement of cocaine-seeking behavior in mice. | Gutiérrez-Cuesta J et al. | — | 2014 | → |
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| Excessive state switching underlies reversal learning deficits in cocaine users. | Patzelt EH et al. | — | 2014 | → |
| Functional status of the serotonin 5-HT2C receptor (5-HT2CR) drives interlocked phenotypes that precipitate relapse-like behaviors in cocaine dependence. | Anastasio NC et al. | — | 2014 | → |
| Gut-brain peptides in corticostriatal-limbic circuitry and alcohol use disorders. | Vadnie CA et al. | — | 2014 | → |
| Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. | Baldan LC et al. | — | 2014 | → |
| Increased impulsivity retards the transition to dorsolateral striatal dopamine control of cocaine seeking. | Murray JE et al. | — | 2014 | → |
| In vivo activity of modafinil on dopamine transporter measured with positron emission tomography and [¹⁸F]FE-PE2I. | Kim W et al. | — | 2014 | → |
| In vivo evidence for greater amphetamine-induced dopamine release in pathological gambling: a positron emission tomography study with [(11)C]-(+)-PHNO. | Boileau I et al. | — | 2014 | → |
| Involvement of dopamine D2 receptors in addictive-like behaviour for acetaldehyde. | Brancato A et al. | — | 2014 | → |
| Machine learning classification of resting state functional connectivity predicts smoking status. | Pariyadath V et al. | — | 2014 | → |
| Methamphetamine self-administration in mice decreases GIRK channel-mediated currents in midbrain dopamine neurons. | Sharpe AL et al. | — | 2014 | → |
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| Moving beyond energy homeostasis: new roles for glucagon-like peptide-1 in food and drug reward. | Reddy IA et al. | — | 2014 | → |
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| Neural circuit modulation during deep brain stimulation at the subthalamic nucleus for Parkinson's disease: what have we learned from neuroimaging studies? | Albaugh DL et al. | — | 2014 | → |
| New perspectives on using brain imaging to study CNS stimulants. | Lukas SE | — | 2014 | → |
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| People are different: tyrosine's modulating effect on cognitive control in healthy humans may depend on individual differences related to dopamine function. | Jongkees BJ et al. | — | 2014 | → |
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| Pharmacologically, are smokers the same as non-smokers? | Bani M et al. | — | 2014 | → |
| Phasic dopamine release drives rapid activation of striatal D2-receptors. | Marcott PF et al. | — | 2014 | → |
| Pilot randomized trial demonstrating reversal of obesity-related abnormalities in reward system responsivity to food cues with a behavioral intervention. | Deckersbach T et al. | — | 2014 | → |
| Poor ability to resist tempting calorie rich food is linked to altered balance between neural systems involved in urge and self-control. | He Q et al. | — | 2014 | → |
| Prefrontal response and frontostriatal functional connectivity to monetary reward in abstinent alcohol-dependent young adults. | Forbes EE et al. | — | 2014 | → |
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