Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse.
paper
Cited
Public
Unavailable
- Authors
- Albertson, Dawn N; Schmidt, Carl J; Kapatos, Gregory; Bannon, Michael J
- Year
- 2006
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 16710320
- DOI
- 10.1038/sj.npp.1301089
- PMCID
- PMC2239258
Drug abuse is thought to induce long-term cellular and behavioral adaptations as a result of alterations in gene expression. Understanding the molecular consequences of addiction may contribute to the development of better treatment strategies. This study utilized high-throughput Affymetrix microarrays to identify gene expression changes in the post-mortem nucleus accumbens of chronic heroin abusers. These data were analyzed independently and in relation to our previously reported data involving human cocaine abusers, in order to determine which expression changes were drug specific and which may be common to the phenomenon of addiction. A significant decrease in the expression of numerous genes encoding proteins involved in presynaptic release of neurotransmitter was seen in heroin abusers, a finding not seen in the cocaine-abusing cohort. Conversely, the striking decrease in myelin-related genes observed in cocaine abusers was not evident in our cohort of heroin subjects. Overall, little overlap in gene expression profiles was seen between the two drug-abusing cohorts: out of the approximately 39,000 transcripts investigated, the abundance of only 25 was significantly changed in both cocaine and heroin abusers, with nearly one-half of these being altered in opposite directions. These data suggest that the profiles of nucleus accumbens gene expression associated with chronic heroin or cocaine abuse are largely unique, despite what are thought to be common effects of these drugs on dopamine neurotransmission in this brain region. A re-examination of our current assumptions about the commonality of molecular mechanisms associated with substance abuse seems warranted.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Cocaine and morphine induce shared and divergent transcriptional regulation in nucleus accumbens D1 and D2 medium spiny neurons. | Browne CJ et al. | β | 2025 | β |
| Identification of variants from gene expression data of opioid-addicted patients. | Ajmeriya S et al. | β | 2025 | β |
| Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction. | Sullivan KA et al. | β | 2025 | β |
| Drug addiction and treatment: An epigenetic perspective. | Koijam AS et al. | β | 2024 | β |
| Identification of novel genetic loci and candidate genes for progressive ethanol consumption in diversity outbred mice. | Mignogna KM et al. | β | 2024 | β |
| A glutamatergic DRN-VTA pathway modulates neuropathic pain and comorbid anhedonia-like behavior in mice. | Wang XY et al. | β | 2023 | β |
| An approach for prioritizing candidate genes from RNA-seq using preclinical cocaine self-administration datasets as a test case. | Vannan A et al. | β | 2023 | β |
| Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies. | Falconnier C et al. | β | 2023 | β |
| Single-cell profiling of glial cells from the mouse amygdala under opioid dependent and withdrawal states. | Yan Y et al. | β | 2023 | β |
| Differential expression of <i>NPAS4</i> in the dorsolateral prefrontal cortex following opioid overdose. | Sosnowski DW et al. | β | 2022 | β |
| Epigenetic Modulation of Opioid Receptors by Drugs of Abuse. | Reid KZ et al. | β | 2022 | β |
| Histone H3 dopaminylation in ventral tegmental area underlies heroin-induced transcriptional and behavioral plasticity in male rats. | Fulton SL et al. | β | 2022 | β |
| Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder. | Xue X et al. | β | 2022 | β |
| Mysterious long noncoding RNAs and their relationships to human disease. | Li W et al. | β | 2022 | β |
| Single nucleus transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine intake. | Reiner BC et al. | β | 2022 | β |
| Analysis of genetic and clinical factors associated with buprenorphine response. | Crist RC et al. | β | 2021 | β |
| A Review on the Expression Pattern of Non-coding RNAs in Patients With Schizophrenia: With a Special Focus on Peripheral Blood as a Source of Expression Analysis. | Ghafouri-Fard S et al. | β | 2021 | β |
| Epigenetic Alterations in Prescription Opioid Misuse: New Strategies for Precision Pain Management. | Gerra MC et al. | β | 2021 | β |
| Facilitating mGluR4 activity reverses the long-term deleterious consequences of chronic morphine exposure in male mice. | Becker JAJ et al. | β | 2021 | β |
| Long non-coding RNAs in motor neuron development and disease. | Vangoor VR et al. | β | 2021 | β |
| Non-Syndromic Intellectual Disability and Its Pathways: A Long Noncoding RNA Perspective. | Barros II et al. | β | 2021 | β |
| Transcriptional Alterations in Dorsolateral Prefrontal Cortex and Nucleus Accumbens Implicate Neuroinflammation and Synaptic Remodeling in Opioid Use Disorder. | Seney ML et al. | β | 2021 | β |
| Convergent functional genomics of cocaine misuse in humans and animal models. | Forero DA et al. | β | 2020 | β |
| Epigenetic Mechanisms of Opioid Addiction. | Browne CJ et al. | β | 2020 | β |
| Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci. | Marees AT et al. | β | 2020 | β |
| A 3' UTR SNP rs885863, a cis-eQTL for the circadian gene VIPR2 and lincRNA 689, is associated with opioid addiction. | Levran O et al. | β | 2019 | β |
| Construction and Analysis of Protein-Protein Interaction Network of Heroin Use Disorder. | Chen SJ et al. | β | 2019 | β |
| Differentially expressed gene networks, biomarkers, long noncoding RNAs, and shared responses with cocaine identified in the midbrains of human opioid abusers. | Saad MH et al. | β | 2019 | β |
| Molecular windows into the human brain for psychiatric disorders. | Egervari G et al. | β | 2019 | β |
| Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol. | Park HM et al. | β | 2019 | β |
| SSS-test: a novel test for detecting positive selection on RNA secondary structure. | Walter Costa MB et al. | β | 2019 | β |
| A Potential Role for the Noncoding Transcriptome in Psychiatric Disorders. | Klengel T | β | 2018 | β |
| Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia. | Avey D et al. | β | 2018 | β |
| Single cell RNAseq uncovers a robust transcriptional response to morphine by oligodendrocytes | Avey D et al. | β | 2018 | β |
| Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability. | Miller ML et al. | β | 2018 | β |
| BLOC-1 deficiency causes alterations in amino acid profile and in phospholipid and adenosine metabolism in the postnatal mouse hippocampus. | van Liempd SM et al. | β | 2017 | β |
| Effects of an acute cannabidiol treatment on cocaine self-administration and cue-induced cocaine seeking in male rats. | Mahmud A et al. | β | 2017 | β |
| The effect of morphine upon DNA methylation in ten regions of the rat brain. | Barrow TM et al. | β | 2017 | β |
| Epigenetics of Stress, Addiction, and Resilience: Therapeutic Implications. | Cadet JL | β | 2016 | β |
| Gomafu lncRNA knockout mice exhibit mild hyperactivity with enhanced responsiveness to the psychostimulant methamphetamine. | Ip JY et al. | β | 2016 | β |
| High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model. | Lo CL et al. | β | 2016 | β |
| Investigating long noncoding RNAs using animal models. | Feyder M et al. | β | 2016 | β |
| Regulatory landscape and clinical implication of MBD3 in human malignant glioma. | Cui Y et al. | β | 2016 | β |
| Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel. | Dickson PE et al. | β | 2016 | β |
| Associating schizophrenia, long non-coding RNAs and neurostructural dynamics. | Merelo V et al. | β | 2015 | β |
| Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions. | Kovacs GG et al. | β | 2015 | β |
| Identification of long noncoding RNAs dysregulated in the midbrain of human cocaine abusers. | Bannon MJ et al. | β | 2015 | β |
| Investigating the potential influence of cause of death and cocaine levels on the differential expression of genes associated with cocaine abuse. | Bannon MJ et al. | β | 2015 | β |
| KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction. | Padula AE et al. | β | 2015 | β |
| Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse. | Korpi ER et al. | β | 2015 | β |
| Mechanisms of Long Non-coding RNAs in Mammalian Nervous System Development, Plasticity, Disease, and Evolution. | Briggs JA et al. | β | 2015 | β |
| Overlapping dopaminergic pathway genetic susceptibility to heroin and cocaine addictions in African Americans. | Levran O et al. | β | 2015 | β |
| Reduced volume of the nucleus accumbens in heroin addiction. | Seifert CL et al. | β | 2015 | β |
| Vitamin D receptor and epigenetics in HIV infection and drug abuse. | Chandel N et al. | β | 2015 | β |
| A molecular profile of cocaine abuse includes the differential expression of genes that regulate transcription, chromatin, and dopamine cell phenotype. | Bannon MJ et al. | β | 2014 | β |
| Developmental changes in the transcriptome of human cerebral cortex tissue: long noncoding RNA transcripts. | Lipovich L et al. | β | 2014 | β |
| Gene expression in the addicted brain. | Zhou Z et al. | β | 2014 | β |
| Loss of BDNF signaling in D1R-expressing NAc neurons enhances morphine reward by reducing GABA inhibition. | Koo JW et al. | β | 2014 | β |
| Molecular mechanisms of long ncRNAs in neurological disorders. | VuΔiΔeviΔ D et al. | β | 2014 | β |
| On finding bicliques in bipartite graphs: a novel algorithm and its application to the integration of diverse biological data types. | Zhang Y et al. | β | 2014 | β |
| The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. | Barry G et al. | β | 2014 | β |
| The neural rejuvenation hypothesis of cocaine addiction. | Dong Y et al. | β | 2014 | β |
| Whole-genome expression profile in zebrafish embryos after chronic exposure to morphine: identification of new genes associated with neuronal function and mu opioid receptor expression. | Herrero-TurriΓ³n MJ et al. | β | 2014 | β |
| Cellular basis of memory for addiction. | Nestler EJ | β | 2013 | β |
| Dopamine receptor D1 and postsynaptic density gene variants associate with opiate abuse and striatal expression levels. | Jacobs MM et al. | β | 2013 | β |
| Comparative peptidomics analysis of neural adaptations in rats repeatedly exposed to amphetamine. | Romanova EV et al. | β | 2012 | β |
| Drug specificity in extended access cocaine and heroin self-administration. | Lenoir M et al. | β | 2012 | β |
| Increased heat shock protein 70 gene expression in the brains of cocaine-related fatalities may be reflective of postdrug survival and intervention rather than excited delirium. | Johnson MM et al. | β | 2012 | β |
| Transcriptome analysis of long non-coding RNAs of the nucleus accumbens in cocaine-conditioned mice. | Bu Q et al. | β | 2012 | β |
| White matter microstructure in opiate addiction. | Bora E et al. | β | 2012 | β |
| Mining Affymetrix microarray data for long non-coding RNAs: altered expression in the nucleus accumbens of heroin abusers. | Michelhaugh SK et al. | β | 2011 | β |
| Neurogenetics and clinical evidence for the putative activation of the brain reward circuitry by a neuroadaptagen: proposing an addiction candidate gene panel map. | Chen TJ et al. | β | 2011 | β |
| Opiate versus psychostimulant addiction: the differences do matter. | Badiani A et al. | β | 2011 | β |
| Association of a polyadenylation polymorphism in the serotonin transporter and panic disorder. | Gyawali S et al. | β | 2010 | β |
| MacroRNA underdogs in a microRNA world: evolutionary, regulatory, and biomedical significance of mammalian long non-protein-coding RNA. | Lipovich L et al. | β | 2010 | β |
| Mass spectrometry screening reveals peptides modulated differentially in the medial prefrontal cortex of rats with disparate initial sensitivity to cocaine. | Romanova EV et al. | β | 2010 | β |
| Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. | Kristiansen LV et al. | β | 2009 | β |
| Convergence and divergence in the etiology of myelin impairment in psychiatric disorders and drug addiction. | Feng Y | β | 2008 | β |
| Correlating human and animal studies of cocaine abuse and gene expression. | Lull ME et al. | β | 2008 | β |
| Effects of chronic morphine and morphine withdrawal on gene expression in rat peripheral blood mononuclear cells. | Desjardins S et al. | β | 2008 | β |
| Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. | Le-Niculescu H et al. | β | 2008 | β |
| Transcriptional correlates of human substance use. | Lehrmann E et al. | β | 2008 | β |
| A perspective on microarrays: current applications, pitfalls, and potential uses. | Jaluria P et al. | β | 2007 | β |
| CNS proteomes in alcohol and drug abuse and dependence. | Matsumoto I et al. | β | 2007 | β |