ZNF804A genetic variation (rs1344706) affects brain grey but not white matter in schizophrenia and healthy subjects.
- Authors
- Nenadic, I; Maitra, R; Basmanav, F B; Schultz, C C; Lorenz, C; Schachtzabel, C; Smesny, S; Nöthen, M M; Cichon, S; Reichenbach, J R; Sauer, H; Schlösser, R G M; Gaser, C
- Year
- 2015
- Journal
- Psychological medicine
- PMID
- 25065377
- DOI
- 10.1017/S0033291714001159
BACKGROUND: Genetic variation in the gene encoding ZNF804A, a risk gene for schizophrenia, has been shown to affect brain functional endophenotypes of the disorder, while studies of white matter structure have been inconclusive. METHOD: We analysed effects of ZNF804A single nucleotide polymorphism rs1344706 on grey and white matter using voxel-based morphometry (VBM) in high-resolution T1-weighted magnetic resonance imaging scans of 62 schizophrenia patients and 54 matched healthy controls. RESULTS: We found a significant (p < 0.05, family-wise error corrected for multiple comparisons) interaction effect of diagnostic group x genotype for local grey matter in the left orbitofrontal and right and left lateral temporal cortices, where patients and controls showed diverging effects of genotype. Analysing the groups separately (at p < 0.001, uncorrected), variation in rs1344706 showed effects on brain structure within the schizophrenia patients in several areas including the left and right inferior temporal, right supramarginal/superior temporal, right and left inferior frontal, left frontopolar, right and left dorsolateral/ventrolateral prefrontal cortices, and the right thalamus, as well as effects within the healthy controls in left lateral temporal, right anterior insula and left orbitofrontal cortical areas. We did not find effects of genotype of regional white matter in either of the two cohorts. CONCLUSIONS: Our findings demonstrate effects of ZNF804A genetic variation on brain structure, with diverging regional effects in schizophrenia patients and healthy controls in frontal and temporal brain areas. These effects, however, might be dependent on the impact of other (genetic or non-genetic) disease factors.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Replication of ZNF804A gene variant associations with risk of heroin addiction. | 2015 | 26382569 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Impact of <i>ZNF804A</i> rs1344706 or <i>CACNA1C</i> rs1006737 polymorphisms on cognition in patients with severe mental disorders: A systematic review and meta-analysis. | Novaes de Oliveira Roldan AC et al. | — | 2023 | → |
| Polymorphism in the ZNF804A Gene and Variation in D<sub>1</sub> and D<sub>2</sub>/D<sub>3</sub> Dopamine Receptor Availability in the Healthy Human Brain: A Dual Positron Emission Tomography Study. | Hegarty CE et al. | — | 2023 | → |
| Enhanced Prefrontal Regional Homogeneity and Its Correlations With Cognitive Dysfunction/Psychopathology in Patients With First-Diagnosed and Drug-Naive Schizophrenia. | Gao S et al. | — | 2020 | → |
| Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies. | Wang S et al. | — | 2019 | → |
| Common variation in ZNF804A (rs1344706) is not associated with brain morphometry in schizophrenia or healthy participants. | Quidé Y et al. | — | 2018 | → |
| Effect of rs1344706 in the <i>ZNF804A</i> gene on the brain network. | Chen X et al. | — | 2018 | → |
| Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment. | Zhou Y et al. | — | 2018 | → |
| Using coordinate-based meta-analyses to explore structural imaging genetics. | Janouschek H et al. | — | 2018 | → |
| Association between RGS4 variants and psychotic-like experiences in nonclinical individuals. | de Castro-Catala M et al. | — | 2017 | → |
| Abnormally increased and incoherent resting-state activity is shared between patients with schizophrenia and their unaffected siblings. | Liu C et al. | — | 2016 | → |
| Frontal lobe alterations in schizophrenia: a review. | Mubarik A et al. | — | 2016 | → |
| Molecular anatomy of the thalamic complex and the underlying transcription factors. | Nagalski A et al. | — | 2016 | → |
| ZNF804A variants confer risk for heroin addiction and affect decision making and gray matter volume in heroin abusers. | Sun Y et al. | — | 2016 | → |
| Genetics, sleep and memory: a recall-by-genotype study of ZNF804A variants and sleep neurophysiology. | Hellmich C et al. | — | 2015 | → |
| Replication of ZNF804A gene variant associations with risk of heroin addiction. | Hancock DB et al. | — | 2015 | → |
| ZNF804A rs1344706 is associated with cortical thickness, surface area, and cortical volume of the unmedicated first episode schizophrenia and healthy controls. | Wei Q et al. | — | 2015 | → |