Functional, molecular and pharmacological advances in 5-HT7 receptor research.
paper
Cited
Public
Unavailable
- Authors
- Hedlund, Peter B; Sutcliffe, J Gregor
- Year
- 2004
- Journal
- Trends in pharmacological sciences
- PMID
- 15559250
- DOI
- 10.1016/j.tips.2004.07.002
The 5-HT7 receptor was among a group of 5-HT receptors that were discovered using targeted cloning strategies 12 years ago. This receptor is a seven-transmembrane-domain G-protein-coupled receptor that is positively linked to adenylyl cyclase. The distributions of 5-HT7 receptor mRNA, immunolabeling and radioligand binding exhibit strong similarities, with the highest receptor densities present in the thalamus and hypothalamus and significant densities present in the hippocampus and cortex. The recent availability of selective antagonists and knockout mice strains has dramatically increased our knowledge about this receptor. Together with unselective agonists, these new tools have helped to reveal the 5-HT7 receptor distribution in more detail. Important functional roles for the 5-HT7 receptor in thermoregulation, circadian rhythm, learning and memory, hippocampal signaling and sleep have also been established. Hypotheses driving current research indicate that this receptor might be involved in mood regulation, suggesting that the 5-HT7 receptor is a putative target in the treatment of depression.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. | 2011 | 21184583 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Distribution of Metabotropic Serotonin Receptors in GABAergic and Glutamatergic Neurons in the Auditory Midbrain. | Galindo KL et al. | β | 2026 | β |
| Impact of 5-HT7 receptor gene deletion on memory and affective behaviors in young and aged mice. | Rodriguez G et al. | β | 2026 | β |
| Conformational Signatures of Preassembled and Active Complexes of 5-HT<sub>7</sub> with the G<sub>s</sub> Protein. | Zara Z et al. | β | 2025 | β |
| Context-dependent roles of 5-HT and its receptors in tumor growth and wound healing: Mechanisms and therapeutic implications. | Zeng Q et al. | β | 2025 | β |
| Distribution of metabotropic serotonergic receptors in GABAergic and glutamatergic neurons in the auditory midbrain | Galindo KL et al. | β | 2025 | β |
| Dual-Selective Terahertz-Nanodisc Metasurfaces for Exploring Neurotransmitter Dynamics beyond Spectral Limitations. | Kim T et al. | β | 2025 | β |
| Elevated 5-HTR7 deteriorates dysregulated megakaryocytopoiesis in immune thrombocytopenic purpura via upregulating the PKA/Orai1/ERK1/2 pathway. | Zhou M et al. | β | 2025 | β |
| Investigation of neuromodulation of the endbulb of Held synapse in the cochlear nucleus by serotonin and norepinephrine. | Groshkova M et al. | β | 2025 | β |
| Involvement of the basolateral amygdaloid nucleus anterior part 5-HT<sub>7</sub> receptors in the regulation of anxiety-like behaviors in hemiparkinsonian rats. | Yang J et al. | β | 2025 | β |
| Serotonin (5-Hydroxytryptamine): Metabolism, Signaling, Biological Functions, Diseases, and Emerging Therapeutic Opportunities. | Zhang Y et al. | β | 2025 | β |
| Therapeutic Effects of Pharmacological Modulation of Serotonin Brain System in Human Patients and Animal Models of Fragile X Syndrome. | Ciranna L et al. | β | 2025 | β |
| Neuroprotective and Neurite Outgrowth Stimulating Effects of New Low-Basicity 5-HT<sub>7</sub> Receptor Agonists: In Vitro Study in Human Neuroblastoma SH-SY5Y Cells. | Jakubowska K et al. | β | 2024 | β |
| An adult Drosophila glioma model to highlight metabolic dysfunctions and evaluate the role of the serotonin 5-HT<sub>7</sub> receptor as a potential therapeutic target. | Bertrand M et al. | β | 2023 | β |
| Development and challenges in the discovery of 5-HT<sub>1A</sub> and 5-HT<sub>7</sub> receptor ligands. | Singh D et al. | β | 2023 | β |
| Enantiomeric Separation, Absolute Configuration by X-ray Crystallographic Analysis, and Functional Evaluation of Enantiomers of the Dual Ligand, SYA0340 at 5-HT<sub>1A</sub> and 5-HT<sub>7A</sub> Receptors. | Bricker BA et al. | β | 2023 | β |
| Mesenchymal stem cell-derived conditioned medium and Methysergide give rise to crosstalk inhibition of 5-HT2A and 5-HT7 receptors in neuroblastoma cells. | Salkin H et al. | β | 2023 | β |
| Studying the Brain Monoaminergic Systems and Neurotrophic Factors in Minipigs with High and Low Tolerance to the Presence of Human. | Bazovkina D et al. | β | 2023 | β |
| Synthesis, computational simulations and biological evaluation of new dual 5HT<sub>1A</sub>/5HT<sub>7</sub> receptor ligands based on purine-2,6-dione scaffold. | ZagΓ³rska A et al. | β | 2023 | β |
| Systematic Review of the Serotonergic System in the Pathophysiology of Severe Dengue: The Theory of Thrombocytopenia and Vascular Extravasation. | Corzo-GΓ³mez J et al. | β | 2023 | β |
| Benefits of Black Cohosh (<i>Cimicifuga racemosa</i>) for Women Health: An Up-Close and In-Depth Review. | Mohapatra S et al. | β | 2022 | β |
| Expression of the Human Serotonin 5-HT<sub>7</sub> Receptor Rescues Phenotype Profile and Restores Dysregulated Biomarkers in a <i>Drosophila melanogaster</i> Glioma Model. | Courant F et al. | β | 2022 | β |
| Hyperthermia and Serotonin: The Quest for a "Better Cyproheptadine". | Petroianu GA | β | 2022 | β |
| Participation of Hippocampal 5-HT<sub>5A</sub>, 5-HT<sub>6</sub> and 5-HT<sub>7</sub> Serotonin Receptors on the Consolidation of Social Recognition Memory. | Schmidt SD et al. | β | 2022 | β |
| Serotonergic mechanisms associated with experimental models of hypoxia: A systematic review. | Carneiro IBC et al. | β | 2022 | β |
| The Implication of 5-HT Receptor Family Members in Aggression, Depression and Suicide: Similarity and Difference. | Popova NK et al. | β | 2022 | β |
| 5-HT Receptors and Temperature Homeostasis. | Voronova IP | β | 2021 | β |
| 5-HT Receptors and the Development of New Antidepressants. | Εlifirski G et al. | β | 2021 | β |
| Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders. | Hopkins SC et al. | β | 2021 | β |
| Impact of specific serotonin receptor modulation on behavioral flexibility. | Alvarez BD et al. | β | 2021 | β |
| Investigation of the Role of Stimulation and Blockade of 5-HT<sub>7</sub> Receptors in Ketamine Anesthesia. | Dincer B et al. | β | 2021 | β |
| New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263. | Ofori E et al. | β | 2021 | β |
| Rewiring of the Serotonin System in Major Depression. | Vahid-Ansari F et al. | β | 2021 | β |
| 5-HT7 Receptor Inhibition Transiently Improves Respiratory Function Following Daily Acute Intermittent Hypercapnic-Hypoxia in Rats With Chronic Midcervical Spinal Cord Contusion. | Wu MJ et al. | β | 2020 | β |
| 5-HT7 receptorsare over-expressed in patients with nasal polyps. | Yayla M et al. | β | 2020 | β |
| Serotonin Type 6 and 7 Receptors as a Novel Therapeutic Target for the Treatment of Schizophrenia. | Tsegay EW et al. | β | 2020 | β |
| Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT<sub>1A</sub>-Mediated cAMP Signaling. | Li J et al. | β | 2020 | β |
| Towards selective CNS PET imaging of the 5-HT<sub>7</sub> receptor system: Past, present and future. | L'Estrade ET et al. | β | 2020 | β |
| Allopregnanolone reversion of estrogen and progesterone memory impairment: interplay with serotonin release. | Escudero C et al. | β | 2019 | β |
| An Association of Serotonin with Pain Disorders and Its Modulation by Estrogens. | Paredes S et al. | β | 2019 | β |
| A new indole alkaloid from <i>Cimicifuga heracleifolia</i>. | Lu J et al. | β | 2019 | β |
| Asenapine for the treatment of bipolar disorder. | Marazziti D et al. | β | 2019 | β |
| Enantioseparation of 5-chloro-2-{2-[3,4-dihydroisoquinoline-2(1H)-yl]ethyl}-2-methyl-2,3-dihydro-1H-inden-1-one (SYA 40247), a high-affinity 5-HT<sub>7</sub> receptor ligand, by HPLC-PDA using amylose tris-(3, 5- dimethylphenylcarbamate) as a chiral stationary phase. | Onyameh EK et al. | β | 2019 | β |
| Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies. | Pham TH et al. | β | 2019 | β |
| Psychotropic Drugs for the Management of Chronic Pain and Itch. | Belinskaia DA et al. | β | 2019 | β |
| Role of 5-HT<sub>7</sub> receptors in the immune system in health and disease. | Quintero-Villegas A et al. | β | 2019 | β |
| 5-HT<sub>1A</sub> parital agonism and 5-HT<sub>7</sub> antagonism restore episodic memory in subchronic phencyclidine-treated mice: role of brain glutamate, dopamine, acetylcholine and GABA. | Huang M et al. | β | 2018 | β |
| Involvement of prelimbic 5-HT<sub>7</sub> receptors in the regulation of anxiety-like behaviors in hemiparkinsonian rats. | Du CX et al. | β | 2018 | β |
| MF-8, a novel promising arylpiperazine-hydantoin based 5-HT<sub>7</sub> receptor antagonist: In vitro drug-likeness studies and in vivo pharmacological evaluation. | Latacz G et al. | β | 2018 | β |
| Review: 5-HT1, 5-HT2, 5-HT3 and 5-HT7 Receptors and their Role in the Modulation of Pain Response in the Central Nervous System. | Cortes-Altamirano JL et al. | β | 2018 | β |
| Serotonin Receptor Binding Characteristics of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook. | Ikarashi Y et al. | β | 2018 | β |
| Spotlight on once-monthly long-acting injectable aripiprazole and its potential as maintenance treatment for bipolar I disorder in adult patients. | Torres-Llenza V et al. | β | 2018 | β |
| Asenapine modulates mood-related behaviors and 5-HT<sub>1A/7</sub> receptors-mediated neurotransmission. | Delcourte S et al. | β | 2017 | β |
| How serotonin receptors regulate morphogenic signalling in neurons. | Wirth A et al. | β | 2017 | β |
| In the search for a lead structure among series of potent and selective hydantoin 5-HT<sub>7</sub> R agents: The drug-likeness in vitro study. | Latacz G et al. | β | 2017 | β |
| In Vivo Effect of a 5-HT<sub>7</sub> Receptor Agonist on 5-HT Neurons and GABA Interneurons in the Dorsal Raphe Nuclei of Sham and PD Rats. | Wang S et al. | β | 2017 | β |
| Low-basicity 5-HT<sub>7</sub> Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol. | Hogendorf AS et al. | β | 2017 | β |
| The effect of sertraline and 8-OH-DPAT on the PTZ_induced seizure threshold: Role of the nitrergic system. | Heydari A et al. | β | 2017 | β |
| 5-HT7 receptor modulators: Amino groups attached to biphenyl scaffold determine functional activity. | Kim Y et al. | β | 2016 | β |
| An overview on therapeutics attenuating amyloid Ξ² level in Alzheimer's disease: targeting neurotransmission, inflammation, oxidative stress and enhanced cholesterol levels. | Zhou X et al. | β | 2016 | β |
| Asenapine at low doses as a treatment for psychotic anxiety. | Robles MartΓnez M et al. | β | 2016 | β |
| Design and synthesis of dual 5-HT1A and 5-HT7 receptor ligands. | Ofori E et al. | β | 2016 | β |
| New advances in the treatment of generalized anxiety disorder: the multimodal antidepressant vortioxetine. | Orsolini L et al. | β | 2016 | β |
| Novel N-acyl-carbazole derivatives as 5-HT7R antagonists. | Kim Y et al. | β | 2016 | β |
| [Pharmacological properties of vortioxetine and its pre-clinical consequences]. | David DJ et al. | β | 2016 | β |
| Potential serotonergic agents for the treatment of schizophrenia. | Garay RP et al. | β | 2016 | β |
| Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation. | Kucwaj-Brysz K et al. | β | 2016 | β |
| Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve inΒ vitro microsomal stability: A case study. | Lacivita E et al. | β | 2016 | β |
| Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors. | Ofori E et al. | β | 2016 | β |
| 5-HT7 receptor modulates GABAergic transmission in the rat dorsal raphe nucleus and controls cortical release of serotonin. | Kusek M et al. | β | 2015 | β |
| 5-HT is a potent relaxant in rat superior mesenteric veins. | Watts SW et al. | β | 2015 | β |
| Activation and blockade of serotonin7 receptors in the prelimbic cortex regulate depressive-like behaviors in a 6-hydroxydopamine-induced Parkinson's disease rat model. | Zhang QJ et al. | β | 2015 | β |
| Altered Ξ³-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants. | Pehrson AL et al. | β | 2015 | β |
| Asenapine versus placebo for schizophrenia. | Hay A et al. | β | 2015 | β |
| Developments in the field of antidepressants, where do we go now? | Artigas F | β | 2015 | β |
| Intrathecal nefopam-induced antinociception through activation of descending serotonergic projections involving spinal 5-HT7 but not 5-HT3 receptors. | Lee HG et al. | β | 2015 | β |
| Involvement of 5-HTβ receptors in vortioxetine's modulation of circadian rhythms and episodic memory in rodents. | Westrich L et al. | β | 2015 | β |
| Multi-Step Protocol for Automatic Evaluation of Docking Results Based on Machine Learning Methods--A Case Study of Serotonin Receptors 5-HT(6) and 5-HT(7). | Smusz S et al. | β | 2015 | β |
| Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis. | Kusumi I et al. | β | 2015 | β |
| The critical role of spinal 5-HT7 receptors in opioid and non-opioid type stress-induced analgesia. | Yesilyurt O et al. | β | 2015 | β |
| Towards novel 5-HT7versus 5-HT1A receptor ligands among LCAPs with cyclic amino acid amide fragments: design, synthesis, and antidepressant properties. Part II. | Canale V et al. | β | 2015 | β |
| (11)C-labeling and preliminary evaluation of vortioxetine as a PET radioligand. | Andersen VL et al. | β | 2014 | β |
| 3D QSAR based design of novel oxindole derivative as 5HT7 inhibitors. | Chitta A et al. | β | 2014 | β |
| 5-HT7 receptors and tryptophan hydroxylase in lymphocytes of rats: mitogen activation, physical restraint or treatment with reserpine. | Urbina M et al. | β | 2014 | β |
| 5-HT7 receptors are involved in neurogenic dural vasodilatation in an experimental model of migraine. | Wang X et al. | β | 2014 | β |
| 5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders. | Ciranna L et al. | β | 2014 | β |
| 7-3-Chlorophenypiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione as a serotonin receptor ligands with potential antidepressant activity. | Zygmunt M et al. | β | 2014 | β |
| Aberrant Rho GTPases signaling and cognitive dysfunction: in vivo evidence for a compelling molecular relationship. | De Filippis B et al. | β | 2014 | β |
| Alterations in brain temperatures as a possible cause of migraine headache. | HorvΓ‘th C | β | 2014 | β |
| Cellular mechanisms of the 5-HT7 receptor-mediated signaling. | Guseva D et al. | β | 2014 | β |
| Common genetic variants and gene expression associated with white matter microstructure in the human brain. | Sprooten E et al. | β | 2014 | β |
| Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HTβ receptor. | Lacivita E et al. | β | 2014 | β |
| Differential expression of hypothalamic fear- and stress-related genes in broiler chickens showing short or long tonic immobility. | Wang S et al. | β | 2014 | β |
| Differential responses to acute administration of a new 5-HT7-R agonist as a function of adolescent pre-treatment: phMRI and immuno-histochemical study. | Altabella L et al. | β | 2014 | β |
| Different role of spinal 5-HT(hydroxytryptamine)7 receptors and descending serotonergic modulation in inflammatory pain induced in formalin and carrageenan rat models. | Yang J et al. | β | 2014 | β |
| Effect of 5-HT7 receptor blockade on liver regeneration after 60-70% partial hepatectomy. | Tzirogiannis KN et al. | β | 2014 | β |
| Interplay between serotonin 5-HT1A and 5-HT7 receptors in depressive disorders. | Naumenko VS et al. | β | 2014 | β |
| Modulation of 5-HT7 receptor: effect on object recognition performances in mice. | Freret T et al. | β | 2014 | β |
| Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression. | Kim Y et al. | β | 2014 | β |
| Novel tricyclic[2,1-f]theophylline derivatives of LCAP with activity in mouse models of affective disorders. | Partyka A et al. | β | 2014 | β |
| PET tracers for serotonin receptors and their applications. | Kumar JS et al. | β | 2014 | β |
| Pharmacological stimulation of the brain serotonin receptor 7 as a novel therapeutic approach for Rett syndrome. | De Filippis B et al. | β | 2014 | β |
| Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. | Pehrson AL et al. | β | 2014 | β |
| Serotonergic therapies for cognitive symptoms in Alzheimer's disease: rationale and current status. | Ramirez MJ et al. | β | 2014 | β |
| Serotonin 5-HT7 receptor is critically involved in acute and chronic inflammation of the gastrointestinal tract. | Guseva D et al. | β | 2014 | β |
| Serotonin modulation of macrophage polarization: inflammation and beyond. | de Las Casas-Engel M et al. | β | 2014 | β |
| Solid-supported synthesis, molecular modeling, and biological activity of long-chain arylpiperazine derivatives with cyclic amino acid amide fragments as 5-HT(7) and 5-HT(1A) receptor ligands. | Canale V et al. | β | 2014 | β |
| Structure-activity relationships and molecular modeling studies of novel arylpiperazinylalkyl 2-benzoxazolones and 2-benzothiazolones as 5-HT(7) and 5-HT(1A) receptor ligands. | Salerno L et al. | β | 2014 | β |
| Synthesis and pharmacological evaluation of a new series of radiolabeled ligands for 5-HT7 receptor PET neuroimaging. | Colomb J et al. | β | 2014 | β |
| The 5-HT7 receptor as a potential target for treating drug and alcohol abuse. | Hauser SR et al. | β | 2014 | β |
| Vortioxetine restores reversal learning impaired by 5-HT depletion or chronic intermittent cold stress in rats. | Wallace A et al. | β | 2014 | β |
| 5-HT radioligands for human brain imaging with PET and SPECT. | Paterson LM et al. | β | 2013 | β |
| Aryl biphenyl-3-ylmethylpiperazines as 5-HT7 receptor antagonists. | Kim J et al. | β | 2013 | β |
| Discovery of aryl-biphenyl-2-ylmethylpiperazines as novel scaffolds for 5-HT(7) ligands and role of the aromatic substituents in binding to the target receptor. | Kim Y et al. | β | 2013 | β |
| Effects of geissoschizine methyl ether, an indole alkaloid in Uncaria hook, a constituent of yokukansan, on human recombinant serotonin 7 receptor. | Ueki T et al. | β | 2013 | β |
| High dose of 8-OH-DPAT decreases maximal dentate gyrus activation and facilitates granular cell plasticity in vivo. | Orban G et al. | β | 2013 | β |
| Inflammation and peripheral 5-HT7 receptors: the role of 5-HT7 receptors in carrageenan induced inflammation in rats. | Albayrak A et al. | β | 2013 | β |
| Multiple roles of serotonin in pain control mechanisms--implications of 5-HTβ and other 5-HT receptor types. | Viguier F et al. | β | 2013 | β |
| Only repeated administration of the serotonergic agonist 8-OH-DPAT improves place learning of rats subjected to fimbria-fornix transection. | MalΓ‘ H et al. | β | 2013 | β |
| Palmitoylation of serotonin receptors. | Gorinski N et al. | β | 2013 | β |
| Peripheral 5-HT7 receptors as a new target for prevention of lung injury and mortality in septic rats. | Cadirci E et al. | β | 2013 | β |
| Serotonin 1A receptors alter expression of movement representations. | Scullion K et al. | β | 2013 | β |
| Serotonin receptors involved in antidepressant effects. | Artigas F | β | 2013 | β |
| Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline. | Liu J et al. | β | 2013 | β |
| Synthesis and evaluation of 1-[2-(4-[(11)C]methoxyphenyl)phenyl]piperazine for imaging of the serotonin 5-HT7 receptor in the rat brain. | Shimoda Y et al. | β | 2013 | β |
| The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling. | Atanes P et al. | β | 2013 | β |
| The serotonin receptor 7 promotes neurite outgrowth via ERK and Cdk5 signaling pathways. | Speranza L et al. | β | 2013 | β |
| Acute and repeated treatment with the 5-HT7 receptor antagonist SB 269970 induces functional desensitization of 5-HT7 receptors in rat hippocampus. | Tokarski K et al. | β | 2012 | β |
| Black cohosh: coming full circle? | Johnson TL et al. | β | 2012 | β |
| Design of novel quinazolinone derivatives as inhibitors for 5HT7 receptor. | Chitta A et al. | β | 2012 | β |
| Effects of the selective 5-HT(7) receptor antagonist SB-269970 in animal models of psychosis and cognition. | Waters KA et al. | β | 2012 | β |
| Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking. | Renner U et al. | β | 2012 | β |
| Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo. | Lacivita E et al. | β | 2012 | β |
| Involvement of 5-HTβ receptors in the pathogenesis of temporal lobe epilepsy. | Yang Z et al. | β | 2012 | β |
| Modulatory effects of two novel agonists for serotonin receptor 7 on emotion, motivation and circadian rhythm profiles in mice. | Adriani W et al. | β | 2012 | β |
| Serotonergic mechanisms as targets for existing and novel antipsychotics. | Meltzer HY | β | 2012 | β |
| Serotonin conflict in sleep-feeding. | Nonogaki K | β | 2012 | β |
| Stress- and antidepressant treatment-induced modifications of 5-HTβ receptor functions in the rat brain. | Tokarski K et al. | β | 2012 | β |
| The 5-HT(7) receptor in learning and memory. | Roberts AJ et al. | β | 2012 | β |
| The multiobjective based design, synthesis and evaluation of the arylsulfonamide/amide derivatives of aryloxyethyl- and arylthioethyl- piperidines and pyrrolidines as a novel class of potent 5-HTβ receptor antagonists. | Zajdel P et al. | β | 2012 | β |
| Amisulpride vs. fluoxetine treatment of chronic fatigue syndrome: a pilot study. | Pardini M et al. | β | 2011 | β |
| Antagonist interaction with the human 5-HT(7) receptor mediates the rapid and potent inhibition of non-G-protein-stimulated adenylate cyclase activity: a novel GPCR effect. | Klein MT et al. | β | 2011 | β |
| Arene- and quinoline-sulfonamides as novel 5-HT7 receptor ligands. | Zajdel P et al. | β | 2011 | β |
| Asenapine: a new focus on the treatment of mania. | Cruz N et al. | β | 2011 | β |
| Differential response to specific 5-Ht(7) versus whole-serotonergic drugs in rat forebrains: a phMRI study. | Canese R et al. | β | 2011 | β |
| Estradiol modulation of cortical, striatal and raphe nucleus 5-HT1A and 5-HT2A receptors of female hemiparkinsonian monkeys after long-term ovariectomy. | SΓ‘nchez MG et al. | β | 2011 | β |
| Evidence for in vivo thermosensitivity of serotonergic neurons in the rat dorsal raphe nucleus and raphe pallidus nucleus implicated in thermoregulatory cooling. | Hale MW et al. | β | 2011 | β |
| Gene expression profile during chondrogenesis in human bone marrow derived mesenchymal stem cells using a cDNA microarray. | Yoo HJ et al. | β | 2011 | β |
| Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. | Zlojutro M et al. | β | 2011 | β |
| In vivo effect of 5-HTβ receptor agonist on pyramidal neurons in medial frontal cortex of normal and 6-hydroxydopamine-lesioned rats: an electrophysiological study. | Fan LL et al. | β | 2011 | β |
| Novel tetrahydropyrido[3,2-c]pyrroles as 5-HT(7) antagonists. | Rudolph DA et al. | β | 2011 | β |
| Pharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategy. | Mnie-Filali O et al. | β | 2011 | β |
| Psychotic exacerbation and emotional dampening in the daily life of patients with schizophrenia switched to aripiprazole therapy: a collection of standardized case reports. | Lataster J et al. | β | 2011 | β |
| Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders. | Leopoldo M et al. | β | 2011 | β |
| Serotonin has kinin-like activity in stimulating secretion by Malpighian tubules of the house cricket Acheta domesticus. | Coast G | β | 2011 | β |
| Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster. | Johnson O et al. | β | 2011 | β |
| Serotonin receptors - from molecular biology to clinical applications. | Pytliak M et al. | β | 2011 | β |
| Swim stress activates serotonergic and nonserotonergic neurons in specific subdivisions of the rat dorsal raphe nucleus in a temperature-dependent manner. | Kelly KJ et al. | β | 2011 | β |
| Synthesis and biological evaluation of potential 5-HT(7) receptor PET radiotracers. | Andries J et al. | β | 2011 | β |
| The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats. | Horiguchi M et al. | β | 2011 | β |
| The role of serotonin in the NMDA receptor antagonist models of psychosis and cognitive impairment. | Meltzer HY et al. | β | 2011 | β |
| 5-HT(7) receptor modulators: a medicinal chemistry survey of recent patent literature (2004 - 2009). | Leopoldo M et al. | β | 2010 | β |
| Chronic hyperammonemia alters the circadian rhythms of corticosteroid hormone levels and of motor activity in rats. | Ahabrach H et al. | β | 2010 | β |
| Cognitive impulsivity in animal models: role of response time and reinforcing rate in delay intolerance with two-choice operant tasks. | Adriani W et al. | β | 2010 | β |
| Early-life treatment of antiserotonin antibodies alters sensitivity to serotonin receptors, nociceptive stimulus and serotonin metabolism in adult rats. | Bhanja S et al. | β | 2010 | β |
| LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor. | Hedlund PB et al. | β | 2010 | β |
| New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation. | Badarau E et al. | β | 2010 | β |
| Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. | Ishibashi T et al. | β | 2010 | β |
| Phe369(7.38) at human 5-HT(7) receptors confers interspecies selectivity to antagonists and partial agonists. | Varin T et al. | β | 2010 | β |
| Selective inhibition of 5-HT7 receptor reduces CGRP release in an experimental model for migraine. | Wang X et al. | β | 2010 | β |
| Serotoninergic fine-tuning of the excitation-inhibition balance in rat visual cortical networks. | Moreau AW et al. | β | 2010 | β |
| The relationship between the daily dose, the plasma concentration of blonanserin, and its plasma anti-dopamine D2 and anti-serotonin 5-HT2A activity. | Suzuki H et al. | β | 2010 | β |
| 5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor. | Shelton J et al. | β | 2009 | β |
| Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo. | Abbas AI et al. | β | 2009 | β |
| Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. | Shahid M et al. | β | 2009 | β |
| Asenapine monotherapy in the acute treatment of both schizophrenia and bipolar I disorder. | Bishara D et al. | β | 2009 | β |
| Benzimidazolone-based serotonin 5-HT1A or 5-HT7R ligands: synthesis and biological evaluation. | Badarau E et al. | β | 2009 | β |
| Constitutive Gs-mediated, but not G12-mediated, activity of the 5-hydroxytryptamine 5-HT7(a) receptor is modulated by the palmitoylation of its C-terminal domain. | Kvachnina E et al. | β | 2009 | β |
| Human 5-HT7 receptor-induced inactivation of forskolin-stimulated adenylate cyclase by risperidone, 9-OH-risperidone and other "inactivating antagonists". | Toohey N et al. | β | 2009 | β |
| Lurasidone: a new drug in development for schizophrenia. | Meyer JM et al. | β | 2009 | β |
| Methylphenidate to adolescent rats drives enduring changes of accumbal Htr7 expression: implications for impulsive behavior and neuronal morphology. | Leo D et al. | β | 2009 | β |
| Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system. | Filip M et al. | β | 2009 | β |
| Pharmacological analysis of the novel, rapid, and potent inactivation of the human 5-Hydroxytryptamine7 receptor by risperidone, 9-OH-Risperidone, and other inactivating antagonists. | Knight JA et al. | β | 2009 | β |
| Pleiotropic effects of neurotransmission during development: modulators of modularity. | Thompson BL et al. | β | 2009 | β |
| Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat. | McLean SL et al. | β | 2009 | β |
| Sulfonamides with the N-alkyl-N'-dialkylguanidine moiety as 5-HT7 receptor ligands. | Zajdel P et al. | β | 2009 | β |
| Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. | Medina RA et al. | β | 2009 | β |
| That warm fuzzy feeling: brain serotonergic neurons and the regulation of emotion. | Lowry CA et al. | β | 2009 | β |
| The 5-HT7 receptor and disorders of the nervous system: an overview. | Hedlund PB | β | 2009 | β |
| The 5-HT7 receptor is involved in allocentric spatial memory information processing. | Sarkisyan G et al. | β | 2009 | β |
| 5-HT(7) receptors in the modulation of cognitive processes. | Cifariello A et al. | β | 2008 | β |
| Assessing the neuronal serotonergic target-based antidepressant stratagem: impact of in vivo interaction studies and knockout models. | Rajkumar R et al. | β | 2008 | β |
| Effect of 5-HT(7) antagonist SB-269970 in the modulation of working and reference memory in the rat. | Gasbarri A et al. | β | 2008 | β |
| Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity. | Galici R et al. | β | 2008 | β |
| Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition. | Semenova S et al. | β | 2008 | β |
| In vitro serotonergic activity of black cohosh and identification of N(omega)-methylserotonin as a potential active constituent. | Powell SL et al. | β | 2008 | β |
| Novel quinazolinone derivatives as 5-HT7 receptor ligands. | Na YH et al. | β | 2008 | β |
| S33138 [N-[4-[2-[(3aS,9bR)-8-cyano-1,3a,4,9b-tetrahydro[1]-benzopyrano[3,4-c]pyrrol-2(3H)-yl)-ethyl]phenylacetamide], a preferential dopamine D3 versus D2 receptor antagonist and potential antipsychotic agent. II. A neurochemical, electrophysiological and behavioral characterization in vivo. | Millan MJ et al. | β | 2008 | β |
| Serotonin receptors. | Nichols DE et al. | β | 2008 | β |
| Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. | Leopoldo M et al. | β | 2008 | β |
| 1H MRS-detectable metabolic brain changes and reduced impulsive behavior in adult rats exposed to methylphenidate during adolescence. | Adriani W et al. | β | 2007 | β |
| 5-HT7, neurogenesis and antidepressants: a promising therapeutic axis for treating depression. | Nandam LS et al. | β | 2007 | β |
| 7-Arylpiperazinylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and some of their purine-2,6,8-trione analogs as 5-HT(1A), 5-HT(2A), and 5-HT(7) serotonin receptor ligands. | ChΕoΕ-Rzepa G et al. | β | 2007 | β |
| Analysis of 5-HT6 and 5-HT7 receptor gene expression in rats showing differences in novelty-seeking behavior. | Ballaz SJ et al. | β | 2007 | β |
| Bivalent ligand approach on 4-[2-(3-methoxyphenyl)ethyl]-1-(2-methoxyphenyl)piperazine: synthesis and binding affinities for 5-HT(7) and 5-HT(1A) receptors. | Leopoldo M et al. | β | 2007 | β |
| Caveolin-1 affects serotonin binding and cell surface levels of human 5-HT7(a) receptors. | SjΓΆgren B et al. | β | 2007 | β |
| Constitutive deletion of the serotonin-7 (5-HT(7)) receptor decreases electrical and chemical seizure thresholds. | Witkin JM et al. | β | 2007 | β |
| Depletion of the lipid raft constituents, sphingomyelin and ganglioside, decreases serotonin binding at human 5-HT7(a) receptors in HeLa cells. | SjΓΆgren B et al. | β | 2007 | β |
| Differential profile of typical, atypical and third generation antipsychotics at human 5-HT7a receptors coupled to adenylyl cyclase: detection of agonist and inverse agonist properties. | Rauly-Lestienne I et al. | β | 2007 | β |
| Enhancement of the anti-immobility action of antidepressants by a selective 5-HT7 receptor antagonist in the forced swimming test in mice. | WesoΕowska A et al. | β | 2007 | β |
| Novel interaction between the human 5-HT7 receptor isoforms and PLAC-24/eIF3k. | De Martelaere K et al. | β | 2007 | β |
| Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents. | Bonaventure P et al. | β | 2007 | β |
| Serotonin and the orchestration of energy balance. | Tecott LH | β | 2007 | β |
| Serotonin decreases generation of dopaminergic neurons from mesencephalic precursors via serotonin type 7 and type 4 receptors. | Parga J et al. | β | 2007 | β |
| Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2. | Leopoldo M et al. | β | 2007 | β |
| Structure of the human 5-HT7 receptor gene and characterization of its promoter region. | Laenen K et al. | β | 2007 | β |
| The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder. | Hedlund PB et al. | β | 2007 | β |
| The 5-HT7 receptor: role in novel object discrimination and relation to novelty-seeking behavior. | Ballaz SJ et al. | β | 2007 | β |
| The role of 5-HT(7) receptors in the control of seizures. | PericiΔ D et al. | β | 2007 | β |
| Am5-HT7: molecular and pharmacological characterization of the first serotonin receptor of the honeybee (Apis mellifera). | Schlenstedt J et al. | β | 2006 | β |
| An mRNA expression analysis of stimulation and blockade of 5-HT7 receptors during memory consolidation. | PΓ©rez-GarcΓa G et al. | β | 2006 | β |
| Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. | SjΓΆgren B et al. | β | 2006 | β |
| Cortical serotonin7, 1D and 1F receptors: effects of schizophrenia, suicide and antipsychotic drug treatment. | Dean B et al. | β | 2006 | β |
| Differential effects of chronic partial sleep deprivation and stress on serotonin-1A and muscarinic acetylcholine receptor sensitivity. | Roman V et al. | β | 2006 | β |
| Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression. | WesoΕowska A et al. | β | 2006 | β |
| Effects of 8-OH-DPAT on hippocampal NADH fluorescence in vivo in anaesthetized rats. | Rex A et al. | β | 2006 | β |
| Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application. | Millan MJ | β | 2006 | β |
| Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation. | Bockaert J et al. | β | 2006 | β |
| Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. | Ikeda M et al. | β | 2006 | β |
| Potential anxiolytic and antidepressant effects of the selective 5-HT7 receptor antagonist SB 269970 after intrahippocampal administration to rats. | WesoΕowska A et al. | β | 2006 | β |
| Reanalysis of constitutively active rat and human 5-HT7(a) receptors in HEK-293F cells demonstrates lack of silent properties for reported neutral antagonists. | Romero G et al. | β | 2006 | β |
| Receptor-based pharmacophores for serotonin 5-HT7R antagonists-implications to selectivity. | KoΕaczkowski M et al. | β | 2006 | β |
| Circadian rhythm phenotype of 5-HT7 receptor knockout mice: 5-HT and 8-OH-DPAT-induced phase advances of SCN neuronal firing. | Sprouse J et al. | β | 2005 | β |
| Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. | Perez-GarcΓa GS et al. | β | 2005 | β |
| Repeated administration of citalopram and imipramine alters the responsiveness of rat hippocampal circuitry to the activation of 5-HT7 receptors. | Tokarski K et al. | β | 2005 | β |