Neuropsychological functioning and severity of ADHD in early childhood: a four-year cross-lagged study.
- Authors
- Rajendran, Khushmand; Rindskopf, David; O'Neill, Sarah; Marks, David J; Nomura, Yoko; Halperin, Jeffrey M
- Year
- 2013
- Journal
- Journal of abnormal psychology
- PMID
- 24364619
- DOI
- 10.1037/a0034237
- PMCID
- PMC4980645
Children with attention deficit/hyperactivity disorder (ADHD) have poorer neuropsychological functioning relative to their typically developing peers. However, it is unclear whether early neuropsychological functioning predicts later ADHD severity and/or the latter is longitudinally associated with subsequent neuropsychological functioning; and whether these relations are different in children with and without early symptoms of ADHD. This study aimed to examine the longitudinal associations between ADHD severity and neuropsychological functioning among children at high and low risk of developing ADHD. Hyperactive/Inattentive (H/I; n = 140) and Typically developing (TD; n = 76) preschoolers (age 3-4 years) were recruited (BL) and followed annually for 3 years (F1, F2, and F3). Teachers rated the children's ADHD severity and impairment using the Behavior Assessment System for Children-2 and the Children's Problem Checklist, respectively. Parent reports of children's ADHD severity were obtained using the Kiddie-Schedule for Affective Disorders and Schizophrenia - Present and Lifetime version. Neuropsychological functioning was assessed using the NEPSY. In the full sample, there were bidirectional longitudinal associations between neuropsychological functioning and ADHD severity between F1 and F3. Among H/I children, neuropsychological functioning at F1 and F2 predicted ADHD severity at F2 and F3, respectively. In contrast, among TD children the only significant relationship observed was that elevated ADHD symptoms at F2 were associated with poorer neuropsychological functioning at F3. Improved neuropsychological functioning may attenuate ADHD symptoms and associated impairment among H/I children during the early school years. Interventions designed to improve neuropsychological functioning among young H/I children may be beneficial in reducing their ADHD severity.
Cross-lagged model linking ADHD Symptoms and Impairment with Neuropsychological FunctioningNote: Ο2(df)= 785.05(437); p<.001; Ο2/df ratio = 1.79; CFI= .92; RMSEA=.06; K= K-SADS(parent), B= BASC-2(teacher), C= CPC (teacher), M=Memory, V=Verbal, S=Sensory Motor, L= Language; E=Attention/Executive;ADHD0, ADHD1, ADHD2 and ADHD3 refer to ADHD symptoms and impairment; NP0, NP1, NP2 and NP3 refer to neuropsychological functioning on the NEPSY at each time pointAll indicators load on to their respective factors at p<.001; ** p<.01 *p<.05
Multi-group ModelNote: Ο2(df) =612.99 (482); p<.001; Ο2/df ratio =1.27; CFI= .94; RMSEA=.04;Bold line between F2 neuropsychological functioning and F3 ADHD severity shows that the path was significantly different between the two groups.K= K-SADS (parent), B= BASC-2 (teacher), C= CPC (teacher), M=Memory, V=Verbal, S=Sensory Motor, L= Language; E=Executive/Attention; ADHD1, ADHD2 and ADHD3 refer to ADHD symptoms and impairment; NP1, NP2, and NP3 refer to neuropsychological functioning; All indicators load on to their respective factors at p<.001; ** p<.01 *p<.05
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Executive Functions, Psychiatric Symptoms and ADHD in Child Psychiatric Patients-Concurrent and Longitudinal Associations from Preschool to School Age. | Seikku T et al. | β | 2025 | β |
| Exploring the Predictive Role of Early Executive Functions and Self-Regulation on Functional Outcome in Neurodevelopmental Disorders: A Systematic Review and Meta-analysis. | M B et al. | β | 2025 | β |
| A novel approach to ADHD classification based on severity and emotional impairment: Findings from artificial intelligence analysis. | Pascual Zapatero I et al. | β | 2024 | β |
| Executive function and spatial abilities in physically active children: an explorative study. | Passarello N et al. | β | 2024 | β |
| The Relationship Between Executive Functions and Externalizing and Internalizing Behaviors in Mexican Preschoolers. | Salvador-Cruz J et al. | β | 2023 | β |
| Universal Design for Learning for Children with ADHD. | Frolli A et al. | β | 2023 | β |
| Machine Learning Prediction of ADHD Severity: Association and Linkage to <i>ADGRL3</i>, <i>DRD4</i>, and <i>SNAP25</i>. | Cervantes-HenrΓquez ML et al. | β | 2022 | β |
| Systematic Review and Meta-analysis: The Science of Early-Life Precursors and Interventions for Attention-Deficit/Hyperactivity Disorder. | Shephard E et al. | β | 2022 | β |
| <i>ADGRL3</i>, <i>FGF1</i> and <i>DRD4</i>: Linkage and Association with Working Memory and Perceptual Organization Candidate Endophenotypes in ADHD. | Cervantes-Henriquez ML et al. | β | 2021 | β |
| Preschool Neuropsychological Predictors of School-aged Sluggish Cognitive Tempo and Inattentive Behaviors. | Becker SP et al. | β | 2021 | β |
| The effect of physical activity with and without cognitive demand on the improvement of executive functions and behavioral symptoms in children with ADHD. | Nejati V et al. | β | 2021 | β |
| The Impact of Attention Deficit-hyperactivity Disorder Symptom Severity on the Effectiveness of Transcranial Direct Current Stimulation (tDCS) on Inhibitory Control. | Nejati V et al. | β | 2021 | β |
| Trajectories of Executive Functions and ADHD Symptoms in Preschoolers and the Role of Negative Parental Discipline. | KΓΌhl E et al. | β | 2021 | β |
| Influence of executive functions on the self-reported health-related quality of life of children with ADHD. | SchwΓΆrer MC et al. | β | 2020 | β |
| The Co-occurrence of Pediatric Obesity and ADHD: an Understanding of Shared Pathophysiology and Implications for Collaborative Management. | O'Hara VM et al. | β | 2020 | β |
| A multi-factorial perspective on ADHD and ODD in school-aged children: What is the role of cognitive regulation, temperament, and parental support? | Frick MA et al. | β | 2019 | β |
| Developmental cascades of internalising symptoms, externalising problems and cognitive ability from early childhood to middle adolescence. | Flouri E et al. | β | 2019 | β |
| Intellectual functioning and executive functions in children and adolescents with attention deficit hyperactivity disorder (ADHD) and specific learning disorder (SLD). | Faedda N et al. | β | 2019 | β |
| Multiple causal pathways in attention-deficit/hyperactivity disorder - Do emerging executive and motivational deviations precede symptom development? | Pauli-Pott U et al. | β | 2019 | β |
| Practitioner Review: Assessment and treatment of preschool children with attention-deficit/hyperactivity disorder. | Halperin JM et al. | β | 2019 | β |
| The Course of Neurocognitive Functioning and Prediction of Behavioral Outcome of ADHD Affected and Unaffected Siblings. | van Lieshout M et al. | β | 2019 | β |
| Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability. | Miller ML et al. | β | 2018 | β |
| Working Memory and Vigilance as Multivariate Endophenotypes Related to Common Genetic Risk for Attention-Deficit/Hyperactivity Disorder. | Nigg JT et al. | β | 2018 | β |
| Changing relations among cognitive abilities across development: implications for measurement and research. | Rizeq J et al. | β | 2017 | β |
| Interactions between levels of attention ability and levels of bilingualism in children's executive functioning. | Sorge GB et al. | β | 2017 | β |
| Neurocognitive Predictors of ADHD Outcome: a 6-Year Follow-up Study. | van Lieshout M et al. | β | 2017 | β |
| Autism spectrum disorder and attention-deficit/hyperactivity disorder in early childhood: A review of unique and shared characteristics and developmental antecedents. | Visser JC et al. | β | 2016 | β |
| Preschool Neuropsychological Measures as Predictors of Later Attention Deficit Hyperactivity Disorder. | Breaux RP et al. | β | 2016 | β |
| White matter microstructure and the variable adult outcome of childhood attention deficit hyperactivity disorder. | Shaw P et al. | β | 2015 | β |
| Healthy body, healthy mind?: the effectiveness of physical activity to treat ADHD in children. | Halperin JM et al. | β | 2014 | β |