Exploring genetic analysis of complex traits through the paradigm of alcohol dependence: summary of GAW11 contributions.
- Authors
- Almasy, L; Borecki, I B
- Year
- 1999
- Journal
- Genetic epidemiology
- PMID
- 10597406
- DOI
- 10.1002/gepi.1370170704
We discuss the Genetic Analysis Workshop 11 analyses of data from the Collaborative Study on the Genetics of Alcoholism from a methodological perspective, concentrating on approaches and issues relevant to linkage and association studies of complex human phenotypes. Genome screening by parametric linkage, nonparametric linkage, association, and combined linkage/association methods are discussed. Issues particular to complex disease include etiologic heterogeneity, multivariate phenotype modeling, and parent-of-origin effects. Other methodological topics discussed are new and enhanced methods, ascertainment, weighting of nonindependent sib pairs, and data cleaning and validation.
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External
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|---|---|---|---|---|
| Detection of Parent-of-Origin Effects for the Variants Associated With Behavioral Disinhibition in the MCTFR Data. | Kong YF et al. | — | 2022 | → |
| Genomewide scan for real-word reading subphenotypes of dyslexia: novel chromosome 13 locus and genetic complexity. | Igo RP et al. | — | 2006 | → |
| A genome scan in multigenerational families with dyslexia: Identification of a novel locus on chromosome 2q that contributes to phonological decoding efficiency. | Raskind WH et al. | — | 2005 | → |
| A genome-wide scanning and fine mapping study of COGA data. | Yang HC et al. | — | 2005 | → |
| Analysis of genes for alcoholism using two-disease-locus models. | Wu CC et al. | — | 2005 | → |
| Genetic imprinting analysis for alcoholism genes using variance components approach. | Shete S et al. | — | 2005 | → |
| Linkage analysis of complex diseases using microsatellites and single-nucleotide polymorphisms: application to alcoholism. | Nsengimana J et al. | — | 2005 | → |
| Age-of-onset of hypertension vs. a single measurement of systolic blood pressure in a combined linkage and segregation analysis. | Daw EW et al. | — | 2003 | → |
| Genome-wide screen for heavy alcohol consumption. | Wyszynski DF et al. | — | 2003 | → |
| Psychopathology in the postgenomic era. | Plomin R et al. | — | 2003 | → |