Intensity dependence of auditory evoked potentials and clinical response to prophylactic lithium medication: a replication study.
paper
Cited
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- Authors
- Hegerl, U; Wulff, H; MΓΌller-Oerlinghausen, B
- Year
- 1992
- Journal
- Psychiatry research
- PMID
- 1289916
- DOI
- 10.1016/0165-1781(92)90022-u
A predictor of clinical response to prophylactic lithium treatment in affective psychoses would be of considerable importance. In a pilot study, responders to prophylactic lithium medication, as compared with nonresponders, were characterized by a steeper slope of the amplitude/stimulus-intensity function (ASF slope) of the N1/P2 component of the auditory evoked potential. We tried to replicate this finding in 34 stabilized outpatients with affective illness who had been treated with lithium for at least 3 years. As in the pilot study, responders were again characterized by steeper ASF slopes than nonresponders. Since a steep ASF slope seems to indicate low central serotonergic function, it is speculated that a steep ASF slope characterizes those patients with a serotonin deficit who respond to serotonin agonists like lithium.
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| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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