Neuroticism, major depression and gender: a population-based twin study.
paper
Cited
Public
Unavailable
- Authors
- Fanous, A; Gardner, C O; Prescott, C A; Cancro, R; Kendler, K S
- Year
- 2002
- Journal
- Psychological medicine
- PMID
- 12102386
- DOI
- 10.1017/s003329170200541x
BACKGROUND: A portion of the genetic risk factors for the personality trait neuroticism (N) may also increase risk for major depression (MD). Females have both higher levels of N and higher rates of MD than males, suggesting that these traits may be more genetically correlated in females. METHODS: Structured interviews, including a lifetime assessment for MD by DSM-III-R criteria, were administered to 863 male-male MZ (monozygotic), 649 male-male DZ (dizygotic), 506 female-female MZ, 345 female-female DZ, and 1,408 opposite-sex twin pairs. N was assessed using the short-form of the Eysenck Personality Questionnaire. A sex-limited Cholesky model was fitted which allowed us to decompose into additive genetic, common environmental, and individual-specific environmental components two main classes of correlations: within-sex between-variable and between-sex within-variable. RESULTS: Our best-fitting model contained only additive genetic and individual-specific environmental factors for both N and MD. The within-sex genetic correlations between N and MD were estimated at +0.68 in men and +0.49 in women. This model fitted only slightly better than one in which the N-MD within-sex genetic correlation was constrained to be equal across the sexes, and estimated at +0.55. There may be sex-specific genes influencing both N and MD. CONCLUSION: Our best-fitting model failed to establish a significant sex difference in the genetic correlation between N and MD. These results, as well as evidence for sex-specific genetic factors for both traits, have implications for the diagnosis, classification, and treatment of the affective disorders, and molecular genetic approaches to the study of these traits.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Personality traits in people with multiple sclerosis: A systematic review and meta-analysis. | Mirmosayyeb O et al. | β | 2026 | β |
| Are big five personality traits associated to suicidal behaviour in adolescents? A systematic review and meta-analysis. | Mota MSSD et al. | β | 2024 | β |
| Common genetic and environmental bases of the mental disorders and personality traits: Special focus on the hierarchical model of psychopathology and NEO-PI-R facets. | MitroviΔ D et al. | β | 2024 | β |
| Neuroticism Is Prospectively Associated With 30-Month Changes in Broadband Internalizing Symptoms, but Not Narrowband Positive Affect or Anxious Arousal, in Emerging Adulthood. | Conway CC et al. | β | 2024 | β |
| Prediction of non-suicidal self-injury (NSSI) among rural Chinese junior high school students: a machine learning approach. | Jiang Z et al. | β | 2024 | β |
| What Do EURO-D Scores Capture? Disentangling Trait and State Variances in Depression Symptoms Across the Adult Life Span in Nine European Nations. | Gana K et al. | β | 2023 | β |
| A broad internalizing dimension accounts for the genetic associations between personality and individual internalizing disorders. | Poore HE et al. | β | 2022 | β |
| Association of personality traits with physical function, cognition, and mood in multiple sclerosis. | Kever A et al. | β | 2022 | β |
| Evolution of Mood Symptomatology Through the COVID-19 Pandemic: Findings From the CovidSense Longitudinal Study. | Moukaddam N et al. | β | 2022 | β |
| Neurobehavioral follow-up of children exposed to selective serotonin reuptake inhibitors in utero. | Cohen LS et al. | β | 2022 | β |
| The Role of Cognitive Coping Mechanisms in the Psychotherapeutic Approach of the Major Depressive Disorder. | PΔtru S et al. | β | 2022 | β |
| A developmental perspective on personality and psychopathology across the life span. | Wilson S et al. | β | 2021 | β |
| Symptom-level modelling unravels the shared genetic architecture of anxiety and depression. | Thorp JG et al. | β | 2021 | β |
| The Mediating Effect of Insomnia on the Relationship between Panic Symptoms and Depression in Patients with Panic Disorder. | Hong S et al. | β | 2021 | β |
| Association between Antidepressant Treatment during Pregnancy and Postpartum Self-Harm Ideation in Women with Psychiatric Disorders: A Cross-Sectional, Multinational Study. | Vallee J et al. | β | 2020 | β |
| Contribution to Family, Friends, School, and Community Is Associated With Fewer Depression Symptoms in Adolescents - Mediated by Self-Regulation and Academic Performance. | Kurtovic A et al. | β | 2020 | β |
| Demographic and Psychosocial Variables Could Predict the Occurrence of Major Depressive Disorder, but Not the Severity of Depression in Patients with First-episode Major Depressive Disorder in China. | Xiong N et al. | β | 2020 | β |
| Distinct Risk Profiles in Social Anxiety Disorder. | Tung ES et al. | β | 2020 | β |
| Genetic stratification of depression by neuroticism: revisiting a diagnostic tradition. | Adams MJ et al. | β | 2020 | β |
| Longitudinal associations between rumination and depressive symptoms in a probability sample of adults. | Whisman MA et al. | β | 2020 | β |
| The UKB envirome of depression: from interactions to synergistic effects. | Hullam G et al. | β | 2019 | β |
| Validating psychosocial pathways of risk between neuroticism and late life depression using a polygenic score approach. | Li JJ et al. | β | 2019 | β |
| Effect of Time-Dependent Selective Serotonin Reuptake Inhibitor Antidepressants During Pregnancy on Behavioral, Emotional, and SocialΒ Development in Preschool-Aged Children. | Lupattelli A et al. | β | 2018 | β |
| Genetic risk of major depressive disorder: the moderating and mediating effects of neuroticism and psychological resilience on clinical and self-reported depression. | Navrady LB et al. | β | 2018 | β |
| Genetics of biologically based psychological differences. | Sallis H et al. | β | 2018 | β |
| Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank. | Hall LS et al. | β | 2018 | β |
| Understanding Mechanisms of Genetic Risk for Adolescent Internalizing and Externalizing Problems: The Mediating Role of Parenting and Personality. | Su J et al. | β | 2018 | β |
| Genome-wide meta-analyses of stratified depression in Generation Scotland and UK Biobank | Hall LS et al. | β | 2017 | β |
| Modeling prior information of common genetic variants improves gene discovery for neuroticism. | Lo MT et al. | β | 2017 | β |
| Psychobiological Factors Affecting Cortisol Variability in Human-Dog Dyads. | SchΓΆberl I et al. | β | 2017 | β |
| Depression in Mexican Americans with diagnosed and undiagnosed diabetes. | Olvera RL et al. | β | 2016 | β |
| Measurement invariance and child temperament: An evaluation of sex and informant differences on the Child Behavior Questionnaire. | Clark DA et al. | β | 2016 | β |
| Most of the genetic covariation between major depressive and alcohol use disorders is explained by trait measures of negative emotionality and behavioral control. | Ellingson JM et al. | β | 2016 | β |
| Testing a hierarchical model of neuroticism and its cognitive facets: Latent structure and prospective prediction of first onsets of anxiety and unipolar mood disorders during 3 years in late adolescence. | Zinbarg RE et al. | β | 2016 | β |
| There's More Than Catastrophizing in Chronic Pain: Low Frustration Tolerance and Self-Downing Also Predict Mental Health in Chronic Pain Patients. | Suso-Ribera C et al. | β | 2016 | β |
| Behavioural effects of fetal antidepressant exposure in a Norwegian cohort of discordant siblings. | Brandlistuen RE et al. | β | 2015 | β |
| Biomarkers of intergenerational risk for depression: a review of mechanisms in longitudinal high-risk (LHR) studies. | Jacobs RH et al. | β | 2015 | β |
| DNA modification study of major depressive disorder: beyond locus-by-locus comparisons. | Oh G et al. | β | 2015 | β |
| Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. | Genetics of Personality Consortium et al. | β | 2015 | β |
| Neuroticism in Remitted Major Depression: Elevated with Early Onset but Not Late Onset of Depression. | Gade A et al. | β | 2015 | β |
| Age at onset of recurrent major depression in Han Chinese women - a replication study. | Yang F et al. | β | 2014 | β |
| A phenotypic null hypothesis for the genetics of personality. | Turkheimer E et al. | β | 2014 | β |
| A review of selected candidate endophenotypes for depression. | Goldstein BL et al. | β | 2014 | β |
| Identical genetic influences underpin behavior problems in adolescence and basic traits of personality. | Lewis GJ et al. | β | 2014 | β |
| Perceived stress has genetic influences distinct from neuroticism and depression. | Rietschel L et al. | β | 2014 | β |
| Personality, coping, risky behavior, and mental disorders in the offspring of parents with bipolar disorder: a comprehensive psychosocial assessment. | Nijjar R et al. | β | 2014 | β |
| The serotonin transporter 5-HTTLPR polymorphism in the association between sleep quality and affect. | Hartmann JA et al. | β | 2014 | β |
| Does personality affect risk for dementia? A systematic review and meta-analysis. | Low LF et al. | β | 2013 | β |
| Evaluation of the unique and specific contributions of dimensions of the triple vulnerability model to the prediction of DSM-IV anxiety and mood disorder constructs. | Brown TA et al. | β | 2013 | β |
| Is positive affect in pregnancy protective of postpartum depression? | Bos SC et al. | β | 2013 | β |
| Personality dimensions as common and broadband-specific features for internalizing and externalizing disorders. | Hink LK et al. | β | 2013 | β |
| Psychoticism and disruptive behavior can be also good predictors of school achievement. | Flores-Mendoza C et al. | β | 2013 | β |
| The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population. | Strohmaier J et al. | β | 2013 | β |
| TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample. | Aragam N et al. | β | 2013 | β |
| Altered inhibition of negative emotions in subjects at family risk of major depressive disorder. | Lisiecka DM et al. | β | 2012 | β |
| Antidepressant effects on emotional temperament: toward a biobehavioral research paradigm for major depressive disorder. | Soskin DP et al. | β | 2012 | β |
| Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. | Vinkhuyzen AA et al. | β | 2012 | β |
| Do Different Depression Phenotypes Have Different Risks for Recurrent Coronary Heart Disease? | Shaffer JA et al. | β | 2012 | β |
| Genetic and environmental causes of individual differences in daily life positive affect and reward experience and its overlap with stress-sensitivity. | Menne-Lothmann C et al. | β | 2012 | β |
| Genetic co-morbidity between neuroticism, anxiety/depression and somatic distress in a population sample of adolescent and young adult twins. | Hansell NK et al. | β | 2012 | β |
| Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes. | Webb BT et al. | β | 2012 | β |
| Meta-analysis of genome-wide association studies for personality. | de Moor MH et al. | β | 2012 | β |
| Neuroticism, acculturation and the cortisol awakening response in Mexican American adults. | Mangold D et al. | β | 2012 | β |
| Personality of parents with bipolar disorder and interpersonal functioning among their offspring: a prospective 10-year study. | Ostiguy CS et al. | β | 2012 | β |
| Self-other representations mediate the relationship between Five-Factor Model depression and depressive states. | Huprich SK et al. | β | 2012 | β |
| Synergistic effect of neuroticism and body mass index on glucose metabolism in nondiabetic adults. | Tsenkova VK et al. | β | 2012 | β |
| Affective and neuroendocrine stress reactivity to an academic examination: influence of the 5-HTTLPR genotype and trait neuroticism. | Verschoor E et al. | β | 2011 | β |
| Blunted affect is associated with hypothalamic--pituitary--adrenal axis (HPA) hypoactivity and elevated CSF-interleukin-1 beta (IL-1Ξ²) in response to lumbar puncture. | Fitzgerald L | β | 2011 | β |
| Does variance in drinking motives explain the genetic overlap between personality and alcohol use disorder symptoms? A twin study of young women. | Littlefield AK et al. | β | 2011 | β |
| Do symptoms of bipolar disorder exhibit seasonal variation? A multisite prospective investigation. | Murray G et al. | β | 2011 | β |
| Effects of acute psychosocial stress exposure on endocrine and affective reactivity in college students differing in the 5-HTTLPR genotype and trait neuroticism. | Verschoor E et al. | β | 2011 | β |
| Neuroticism, depressive symptoms, and serum BDNF. | Terracciano A et al. | β | 2011 | β |
| The direct and interactive effects of neuroticism and life stress on the severity and longitudinal course of depressive symptoms. | Brown TA et al. | β | 2011 | β |
| The effects of neuroticism, extraversion, and positive and negative life events on a one-year course of depressive symptoms in euthymic previously depressed patients versus healthy controls. | Spinhoven P et al. | β | 2011 | β |
| The relationship between neuroticism, major depressive disorder and comorbid disorders in Chinese women. | Xia J et al. | β | 2011 | β |
| Translational epidemiology in psychiatry: linking population to clinical and basic sciences. | Weissman MM et al. | β | 2011 | β |
| A genome-wide association study of neuroticism in a population-based sample. | Calboli FC et al. | β | 2010 | β |
| Anxiety, neuroticism and oxidative stress: cross-sectional study in non-smoking college students. | Matsushita M et al. | β | 2010 | β |
| Association between alexithymia, neuroticism, and social desirability scores among Italian graduate students. | Messina A et al. | β | 2010 | β |
| Cognitive style, personality and vulnerability to postnatal depression. | Jones L et al. | β | 2010 | β |
| Conceptual background, development, and preliminary data from the unified protocol for transdiagnostic treatment of emotional disorders. | Wilamowska ZA et al. | β | 2010 | β |
| Familial risk for mood disorder and the personality risk factor, neuroticism, interact in their association with frontolimbic serotonin 2A receptor binding. | Frokjaer VG et al. | β | 2010 | β |
| Family matters: happiness in nuclear families and twins. | Nes RB et al. | β | 2010 | β |
| Gene-environment correlations in the stress-depression relationship. | Schnittker J | β | 2010 | β |
| Genetic contribution to the relationship between personality and depressive symptoms among older women. | Pakkala I et al. | β | 2010 | β |
| Genome-wide association scan for five major dimensions of personality. | Terracciano A et al. | β | 2010 | β |
| Genome-wide association scan of trait depression. | Terracciano A et al. | β | 2010 | β |
| The BDNF Val66Met polymorphism and anxiety: support for animal knock-in studies from a genetic association study in humans. | Montag C et al. | β | 2010 | β |
| The genetics of mood disorders. | Lau JY et al. | β | 2010 | β |
| The Northwestern-UCLA youth emotion project: Associations of cognitive vulnerabilities, neuroticism and gender with past diagnoses of emotional disorders in adolescents. | Zinbarg RE et al. | β | 2010 | β |
| Accurate, Large-Scale Genotyping of 5HTTLPR and Flanking Single Nucleotide Polymorphisms in an Association Study of Depression, Anxiety, and Personality Measures. | Wray NR et al. | β | 2009 | β |
| A proposal for a dimensional classification system based on the shared features of the DSM-IV anxiety and mood disorders: implications for assessment and treatment. | Brown TA et al. | β | 2009 | β |
| Dysbindin gene (DTNBP1) in major depression: association with clinical response to selective serotonin reuptake inhibitors. | Arias B et al. | β | 2009 | β |
| Evidence for an association of the big five personality factors with recurrence of depressive symptoms in later life. | Steunenberg B et al. | β | 2009 | β |
| Public health significance of neuroticism. | Lahey BB | β | 2009 | β |
| Sex-specific association of depression and a haplotype in leukotriene A4 hydrolase gene. | Zhao J et al. | β | 2009 | β |
| The role of personality in comorbidity among anxiety and depressive disorders in primary care and specialty care: a cross-sectional analysis. | Spinhoven P et al. | β | 2009 | β |
| Transition from stress sensitivity to a depressive state: longitudinal twin study. | Wichers M et al. | β | 2009 | β |
| A genome-wide scan for Eysenckian personality dimensions in adolescent twin sibships: psychoticism, extraversion, neuroticism, and lie. | Gillespie NA et al. | β | 2008 | β |
| Association of the dopamine D4 receptor (DRD4) gene and approach-related personality traits: meta-analysis and new data. | MunafΓ² MR et al. | β | 2008 | β |
| Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression. | Wray NR et al. | β | 2008 | β |
| Cortisol and ACTH responses to the Dex/CRH test: influence of temperament. | Tyrka AR et al. | β | 2008 | β |
| Family history of depression is associated with younger age of onset in patients with recurrent depression. | Tozzi F et al. | β | 2008 | β |
| Frontolimbic serotonin 2A receptor binding in healthy subjects is associated with personality risk factors for affective disorder. | Frokjaer VG et al. | β | 2008 | β |
| Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands. | Wray NR et al. | β | 2008 | β |
| Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus. | Fullerton JM et al. | β | 2008 | β |
| Is generalized anxiety disorder an anxiety or mood disorder? Considering multiple factors as we ponder the fate of GAD. | Mennin DS et al. | β | 2008 | β |
| Occupational stress and depression in Korean employees. | Cho JJ et al. | β | 2008 | β |
| Susceptibility to depression expressed as alterations in cortisol day curve: a cross-twin, cross-trait study. | Wichers MC et al. | β | 2008 | β |
| The BDNF Val(66)Met x 5-HTTLPR x child adversity interaction and depressive symptoms: An attempt at replication. | Wichers M et al. | β | 2008 | β |
| The catechol-O-methyl transferase Val158Met polymorphism and experience of reward in the flow of daily life. | Wichers M et al. | β | 2008 | β |
| The nosologic relationship between generalized anxiety disorder and major depression. | Hettema JM | β | 2008 | β |
| The role of internalizing and externalizing liability factors in accounting for gender differences in the prevalence of common psychopathological syndromes. | Kramer MD et al. | β | 2008 | β |
| What is the genetic relationship between anxiety and depression? | Hettema JM | β | 2008 | β |
| A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence. | Kuo PH et al. | β | 2007 | β |
| A longitudinal study of personality and major depression in a population-based sample of male twins. | Fanous AH et al. | β | 2007 | β |
| Depressive disorders among young Canadians: associated factors of continuity and discontinuity. | Nguyen CT et al. | β | 2007 | β |
| Evidence that moment-to-moment variation in positive emotions buffer genetic risk for depression: a momentary assessment twin study. | Wichers MC et al. | β | 2007 | β |
| Factor analysis of the Dutch-language version of the MCMI-III. | Rossi G et al. | β | 2007 | β |
| Genetic risk of depression and stress-induced negative affect in daily life. | Wichers M et al. | β | 2007 | β |
| Interrelationship of childhood trauma, neuroticism, and depressive phenotype. | Moskvina V et al. | β | 2007 | β |
| Is it time to reassess the BDNF hypothesis of depression? | Groves JO | β | 2007 | β |
| Risk for recurrence in depression. | Burcusa SL et al. | β | 2007 | β |
| Symptoms of anxiety and depression in young adults: genetic and environmental influences on stability and change. | Nes RB et al. | β | 2007 | β |
| The comparative validity of 11 modern personality inventories: predictions of behavioral acts, informant reports, and clinical indicators. | Grucza RA et al. | β | 2007 | β |
| The relationship between depressive personality disorder and major depressive disorder: a population-based twin study. | Γrstavik RE et al. | β | 2007 | β |
| The serotonin receptor 2A gene moderates the influence of parental socioeconomic status on adulthood harm avoidance. | Jokela M et al. | β | 2007 | β |
| A population-based twin study of the relationship between neuroticism and internalizing disorders. | Hettema JM et al. | β | 2006 | β |
| Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism. | Hettema JM et al. | β | 2006 | β |
| A Swedish national twin study of lifetime major depression. | Kendler KS et al. | β | 2006 | β |
| A twin study of lifetime Generalized Anxiety Disorder (GAD) in older adults: genetic and environmental influences shared by neuroticism and GAD. | Mackintosh MA et al. | β | 2006 | β |
| DCNP1: a novel candidate gene for major depression. | Willis-Owen SA et al. | β | 2006 | β |
| Do personality traits predict first onset in depressive and bipolar disorder? | Christensen MV et al. | β | 2006 | β |
| Neuroticism and physical disorders among adults in the community: results from the National Comorbidity Survey. | Goodwin RD et al. | β | 2006 | β |
| Neuroticism mediates the association of the serotonin transporter gene with lifetime major depression. | MunafΓ² MR et al. | β | 2006 | β |
| Temperament and hypothalamic-pituitary-adrenal axis function in healthy adults. | Tyrka AR et al. | β | 2006 | β |
| The relationship of neuroticism and extraversion to symptoms of anxiety and depression in the general population. | JylhΓ€ P et al. | β | 2006 | β |
| A genome scan of neuroticism in nicotine dependent smokers. | Neale BM et al. | β | 2005 | β |
| Association analysis of monoamine genes with measures of depression and anxiety in a selected community sample of siblings. | Nash MW et al. | β | 2005 | β |
| Association of personality and work conditions with depressive symptoms. | Jurado D et al. | β | 2005 | β |
| Cognitive style in bipolar disorder. | Jones L et al. | β | 2005 | β |
| Depressive symptoms during childhood and adult obesity: the Zurich Cohort Study. | Hasler G et al. | β | 2005 | β |
| Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework. | Fanous AH et al. | β | 2005 | β |
| Personality traits as intermediary phenotypes in suicidal behavior: genetic issues. | Baud P | β | 2005 | β |
| Psychiatric genetics: a methodologic critique. | Kendler KS | β | 2005 | β |
| The genetics of depression and related traits. | Huezo-Diaz P et al. | β | 2005 | β |
| The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism. | Willis-Owen SA et al. | β | 2005 | β |
| Discovering endophenotypes for major depression. | Hasler G et al. | β | 2004 | β |
| Gender differences in depression: the role of personality factors. | Goodwin RD et al. | β | 2004 | β |
| Gene-environment interplay in affect and dementia: emotional modulation of cognitive expression in personal outcomes. | Palomo T et al. | β | 2004 | β |
| Gene-environment interplay in schizopsychotic disorders. | Palomo T et al. | β | 2004 | β |
| Generalized anxiety disorder and major depressive disorder comorbidity: an example of genetic pleiotropy? | Gorwood P | β | 2004 | β |
| Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism. | Hettema JM et al. | β | 2004 | β |
| High neuroticism and depressive temperament are associated with dysfunctional regulation of the hypothalamic-pituitary-adrenocortical system in healthy volunteers. | Zobel A et al. | β | 2004 | β |
| Patient satisfaction with outpatient psychiatric treatment: the role of diagnosis, pharmacotherapy, and perceived therapeutic change. | Hasler G et al. | β | 2004 | β |
| The genetic relationship of personality to major depression and schizophrenia. | Fanous AH et al. | β | 2004 | β |
| The interrelationship of neuroticism, sex, and stressful life events in the prediction of episodes of major depression. | Kendler KS et al. | β | 2004 | β |
| Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. | Fullerton J et al. | β | 2003 | β |
| Personality and psychopathology: working toward the bigger picture. | Krueger RF et al. | β | 2003 | β |
| Positron emission tomography imaging in depression: a neural systems perspective. | Mayberg HS | β | 2003 | β |
| The relation between depression and anxiety: an evaluation of the tripartite, approach-withdrawal and valence-arousal models. | Shankman SA et al. | β | 2003 | β |
| There was no sex difference in genetic correlations between neuroticism and major depression. | Bienvenu OJ | β | 2003 | β |