Clinical pharmacology of nicotine: implications for understanding, preventing, and treating tobacco addiction.
paper
Cited
Public
Unavailable
- Authors
- Benowitz, N L
- Year
- 2008
- Journal
- Clinical pharmacology and therapeutics
- PMID
- 18305452
- DOI
- 10.1038/clpt.2008.3
Understanding the basic and clinical pharmacology of nicotine provides a basis for improved prevention and treatment of tobacco addiction. Nicotine acts on nicotinic cholinergic receptors in the brain to release dopamine and other neurotransmitters that sustain addiction. Neuroadaptation and tolerance involve changes in both nicotinic receptors and neural plasticity. Nicotine addiction can occur in the context of physical dependence characterized by self-medication to modulate negative affect and/or to relieve withdrawal symptoms, as well as, in light or occasional smokers, primarily for positive reinforcement in specific situations. Nicotine is metabolized primarily by CYP2A6. Its clearance exhibits considerable individual variability that is determined by genetic, racial, and hormonal (sex) factors. Genetically slow metabolism of nicotine appears to be associated with a lower level of dependence. Nicotine dependence is highly heritable and appears to be influenced by genes coding for some nicotine receptor subtypes, some neurotransmitter genes, and genes involved in neural connectivity. Novel pharmacotherapies for nicotine dependence include partial agonists for nicotinic receptors and nicotine vaccines. Pharmacogenetic studies suggest various candidate genes and a nicotine metabolism phenotype that influence outcome. Human pharmacology studies of nicotine and smoking behavior also provide a basis for assessing the benefits and risks of long-term nicotine use for harm reduction and for a potential cigarette regulatory strategy that includes reducing nicotine content of cigarettes to nonaddictive levels.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| From Tobacco to Ultraprocessed Food: How Industry Engineering Fuels the Epidemic of Preventable Disease. | Gearhardt AN et al. | β | 2026 | β |
| Pathology of oral nicotine pouches and their addiction mechanisms. | Zou H et al. | β | 2026 | β |
| Safety and Efficacy of Monoamine Oxidase Inhibitors in Patients Who Use Psychoactive Substances: Potential Drug Interactions and Substance Use Disorder Treatment Data. | Rached G et al. | β | 2026 | β |
| Understanding female smoking in urban China: motivations, stigma and shifting social norms-a qualitative focus group study. | Xie X et al. | β | 2026 | β |
| Acute Effects of Nicotine on Non-Drug-Related Reward in Smokers and Non-Smokers. | Rycroft N et al. | β | 2025 | β |
| Are we disadvantaging smokers by excluding them from kidney transplantation? A single-centre experience and survey of kidney transplantation units. | Hazim H et al. | β | 2025 | β |
| Biomarkers of Exposure to Nicotine and Selected Toxicants in Individuals Who Use Alternative Tobacco Products Sold in Japan and Canada from 2018 to 2019. | Miller CR et al. | β | 2025 | β |
| Biomarkers of Nicotine and Tobacco Carcinogen Exposure in Socioeconomically Disadvantaged Black Adults Receiving a Brief Smoking Reduction Intervention. | Brett EI et al. | β | 2025 | β |
| Changes in Locomotor Activity Observed During Acute Nicotine Withdrawal Can Be Attenuated by Ghrelin and GHRP-6 in Rats. | Ayman J et al. | β | 2025 | β |
| Early repolarization pattern with oral liquid nicotine. | Wolfes J et al. | β | 2025 | β |
| Knowledge and perceptions of nicotine, smoking cessation and electronic nicotine delivery systems among physicians and pharmacists in a Swiss hospital group. | Christen SE et al. | β | 2025 | β |
| MMP12 deficiency attenuates menthol e-cigarette plus house dust-mite effects on pulmonary iron homeostasis and oxidative stress. | Pinkston RI et al. | β | 2025 | β |
| Physical and Chemical Characterization of Aerosols Produced from Commercial Nicotine Salt-Based E-Liquids. | Harris T | β | 2025 | β |
| Racial/ethnic differences in the association between menthol cigarette use and mental illness among adults who smoke in the United States. | White AM et al. | β | 2025 | β |
| Self-reported smoking, urine cotinine, and risk of incident hypertension: findings from the PREVEND prospective cohort study. | Kunutsor SK et al. | β | 2025 | β |
| Sex-dependent differences in the ability of nicotine to modulate discrimination learning and cognitive flexibility in mice. | Aomine Y et al. | β | 2025 | β |
| Understanding Tobacco and Cannabis Co-Use, Cessation Strategies and Intervention Opportunities with Young Adults in UK Further Education Colleges: A Mixed Methods Study. | Walsh H et al. | β | 2025 | β |
| Vaginal pharmacomicrobiomics modulates risk of persistent and recurrent bacterial vaginosis. | Amabebe E et al. | β | 2025 | β |
| An overview of traditional smoking cessation interventions and E-cigarettes. | Alshehri FS | β | 2024 | β |
| Chronic tobacco smoking and neurocognitive impairments in adolescents and young adults: a systematic review and meta-analysis. | Elatfy A et al. | β | 2024 | β |
| Clinical factors associated with smoking cessation among smokers with Chronic Obstructive Pulmonary Disease by sex: Longitudinal analyses from French smoking cessation services. | AllagbΓ© I et al. | β | 2024 | β |
| Comparison of brain nicotine accumulation from traditional combustible cigarettes and electronic cigarettes with different formulations. | Zuo Y et al. | β | 2024 | β |
| Does the time to nicotine dependence vary by internalizing symptoms for young people who use e-cigarettes? An analysis of the Population Assessment of Tobacco and Health (PATH) study, (Waves 1-5; 2013-2019). | Adjei A et al. | β | 2024 | β |
| E-cigarettes, synthetic nicotine, heated-tobacco and smokeless nicotine delivery products: the nicotine landscape beyond combustible cigarettes. | Liakoni E et al. | β | 2024 | β |
| Educating adolescents on preventing substance use: The role of 24-h movement behaviors β data from 2021 Youth Risk Behavior Surveillance. | Cheng Y et al. | β | 2024 | β |
| Electronic cigarettes and cardiovascular disease: epidemiological and biological links. | Zong H et al. | β | 2024 | β |
| Electronic cigarette usage amongst high school students in South Africa: a mixed methods approach. | van Zyl-Smit RN et al. | β | 2024 | β |
| Former smoking, but not active smoking, is associated with delirium in postoperative ICU patients: a matched case-control study. | Komninou MA et al. | β | 2024 | β |
| Indigenous Smokeless Tobacco - Analysing pH, Moisture, Nicotine Levels, and Warning Labels - An In Vitro Study. | Kengadaran S et al. | β | 2024 | β |
| Mass spectrometry-based metabolomics study of nicotine exposure in THP-1 monocytes | Uhlig S et al. | β | 2024 | β |
| Mass spectrometry-based metabolomics study of nicotine exposure in THP-1 monocytes. | Uhlig S et al. | β | 2024 | β |
| Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3'-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine. | Tang Y et al. | β | 2024 | β |
| Racial and Ethnic Disparities in Adolescent Combustible Tobacco Smoking From 2014 to 2020: Declines Are Lagging Among Non-Hispanic Black Youth. | Mantey DS et al. | β | 2024 | β |
| Self-reported smoking, urine cotinine, and risk of type 2 diabetes: Findings from the PREVEND prospective cohort study. | Kunutsor SK et al. | β | 2024 | β |
| The Role of Nicotine Metabolic Rate on Nicotine Dependence and Rewarding: Nicotine Metabolism in Chinese Male Smokers and Male Mice. | Liu M et al. | β | 2024 | β |
| Time to first report of signs of nicotine dependence among youth who use e-cigarettes and cigarettes in the United States: A nationally representative cohort study, findings from the Population Assessment of Tobacco and Health, 2013-2019. | Adjei A et al. | β | 2024 | β |
| Urine cotinine versus self-reported smoking and the risk of chronic kidney disease. | Kunutsor SK et al. | β | 2024 | β |
| Amelioration of Nicotine-Induced Conditioned Place Preference Behaviors in Mice by an FABP3 Inhibitor. | Jia W et al. | β | 2023 | β |
| Effect of Cigarette Smoke Exposure and Aspirin Treatment on Neurotransmitters' Tissue Content in Rats' Hippocampus and Amygdala. | Hammad AM et al. | β | 2023 | β |
| Nicotine's effect on cognition, a friend or foe? | Wang Q et al. | β | 2023 | β |
| The cytisine-enriched poly(3-hydroxybutyrate) fibers for sustained-release dosage form. | Czerniecka-Kubicka A et al. | β | 2023 | β |
| Accuracy and applications of sequencing and genotyping approaches for CYP2A6 and homologous genes. | Langlois AWR et al. | β | 2022 | β |
| Assessment of nicotine delivery and uptake in users of various tobacco/nicotine products. | Scherer G et al. | β | 2022 | β |
| Comparative Assessment of Outcomes in Drug Treatment for Smoking Cessation and Role of Genetic Polymorphisms of Human Nicotinic Acetylcholine Receptor Subunits. | Muderrisoglu A et al. | β | 2022 | β |
| Comparison of brain nicotine uptake from electronic cigarettes and combustible cigarettes. | Zuo Y et al. | β | 2022 | β |
| Detection of Vascular Inflammation and Oxidative Stress by Cotinine in Smokers: Measured Through Interleukin-6 and Superoxide Dismutase. | Kumboyono K et al. | β | 2022 | β |
| How laboratory studies of cigarette craving can inform the experimental alcohol craving literature. | Creswell KG et al. | β | 2022 | β |
| Internalizing problems are associated with initiation and past 30-Day use of flavored tobacco products. | Ganz O et al. | β | 2022 | β |
| Nicotine delivery and cigarette equivalents from vaping a JUULpod. | Prochaska JJ et al. | β | 2022 | β |
| Recyclable molecularly imprinted polymers based on Fe<sub>3</sub>O<sub>4</sub>@SiO<sub>2</sub> and PAMAM dendrimers for the determination of myosmine in cigarettes. | Dai Y et al. | β | 2022 | β |
| Stimulus functions of nicotine. | LeSage MG | β | 2022 | β |
| The interaction between Environmental Enrichment and fluoxetine in inhibiting sucrose-seeking renewal in mice depend on socialΒ living condition. | Pintori N et al. | β | 2022 | β |
| Clinical Pharmacology of Electronic Nicotine Delivery Systems (ENDS): Implications for Benefits and Risks in the Promotion of the Combusted Tobacco Endgame. | Benowitz NL et al. | β | 2021 | β |
| Commentary on Chan et al. : Urgent need for more sophisticated research designs to examine the association between adolescent e-cigarette use and future smoking initiation. | Taylor GMJ et al. | β | 2021 | β |
| Dynamic models of stress-smoking responses based on high-frequency sensor data. | Hojjatinia S et al. | β | 2021 | β |
| E-Cigarettes as a Growing Threat for Children and Adolescents: Position Statement From the European Academy of Paediatrics. | Bush A et al. | β | 2021 | β |
| Environmental enrichment-inspired pharmacological tools for the treatment of addiction. | Solinas M et al. | β | 2021 | β |
| GABA concentrations in the anterior cingulate and dorsolateral prefrontal cortices: Associations with chronic cigarette smoking, neurocognition, and decision making. | Durazzo TC et al. | β | 2021 | β |
| Gender differences within the barriers to smoking cessation and the preferences for interventions in primary care a qualitative study using focus groups in The Hague, The Netherlands. | Dieleman LA et al. | β | 2021 | β |
| Levamisole, a cocaine cutting agent, induces acute and subchronic systemic alterations in Wistar rats. | Laurentino AOM et al. | β | 2021 | β |
| Nicotine metabolite ratio: Comparison of the three urinary versions to the plasma version and nicotine clearance in three clinical studies. | Giratallah HK et al. | β | 2021 | β |
| Sexual identity differences in biomarkers of tobacco exposure among women in a national sample. | Evans-Polce RJ et al. | β | 2021 | β |
| Tobacco-induced sleep disturbances: A systematic review and meta-analysis. | Catoire S et al. | β | 2021 | β |
| Acute and chronic sympathomimetic effects of e-cigarette and tobacco cigarette smoking: role of nicotine and non-nicotine constituents. | Arastoo S et al. | β | 2020 | β |
| Application of the Chinese Version of the BIS/BAS Scales in Participants With a Substance Use Disorder: An Analysis of Psychometric Properties and Comparison With Community Residents. | Che Q et al. | β | 2020 | β |
| Brain death following ingestion of E-cigarette liquid nicotine refill solution. | Scarpino M et al. | β | 2020 | β |
| Differential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers. | Jensen KP et al. | β | 2020 | β |
| Effect of 4-Fluoro-N-(4-Sulfamoylbenzyl) Benzene Sulfonamide on Acquisition and Expression of Nicotine-Induced Behavioral Sensitization and Striatal Adenosine Levels. | Ur Rehman N et al. | β | 2020 | β |
| Effects of Genetic Polymorphisms of Drug Transporter ABCB1 (MDR1) and Cytochrome P450 Enzymes CYP2A6, CYP2B6 on Nicotine Addiction and Smoking Cessation. | Muderrisoglu A et al. | β | 2020 | β |
| Efficacy and Safety of a Nicotine Mouth Spray for Smoking Cessation: A Randomized, Multicenter, Controlled Study in a Naturalistic Setting. | Nides M et al. | β | 2020 | β |
| Exposure to Commercial Cigarette Smoke Produces Psychomotor Sensitization Via Hyperstimulation of Glutamate Response in the Dorsal Striatum. | Ryu IS et al. | β | 2020 | β |
| Glial cells as therapeutic targets for smoking cessation. | Kumar M et al. | β | 2020 | β |
| Mitigating Effects of <i>Liriope platyphylla</i> on Nicotine-Induced Behavioral Sensitization and Quality Control of Compounds. | Yoon D et al. | β | 2020 | β |
| Nicotine Effects, Body Weight Concerns and Smoking: A Literature Review. | Cepeda-Benito A | β | 2020 | β |
| Nicotine treatment buffers negative behavioral consequences induced by exposure to physical and emotional stress in adolescent male mice. | Parise LF et al. | β | 2020 | β |
| Receptivity to Tobacco Advertising among Young Adults with Internalizing Problems: Findings from the Population Assessment of Tobacco and Health Study. | Ganz O et al. | β | 2020 | β |
| Reduction in Exposure to Selected Harmful and Potentially Harmful Constituents Approaching Those Observed Upon Smoking Abstinence in Smokers Switching to the Menthol Tobacco Heating System 2.2 for 3 Months (Part 1). | Haziza C et al. | β | 2020 | β |
| Relating individual differences in nicotine dependence severity to underpinning motivational and pharmacological processes among smokers from vulnerable populations. | Higgins ST et al. | β | 2020 | β |
| Relating Nicotine Plasma Concentration to Momentary Craving Across Four Nicotine Replacement Therapy Formulations. | Germovsek E et al. | β | 2020 | β |
| The Relationship Between Food Craving, Appetite-Related Hormones and Clinical Parameters in Bipolar Disorder. | Platzer M et al. | β | 2020 | β |
| Using Nicotine Gum to Assist Nondaily Smokers in Quitting: A Randomized Clinical Trial. | Shiffman S et al. | β | 2020 | β |
| Considerations when selecting pharmacotherapy for nicotine dependence. | Dodd S et al. | β | 2019 | β |
| Current advances in research in treatment and recovery: Nicotine addiction. | Prochaska JJ et al. | β | 2019 | β |
| Development and psychometric properties of the tobacco and nicotine consequences scale (TANCS) to screen for cigarette and e-cigarette misuse in community settings. | Grigsby TJ | β | 2019 | β |
| Effect of Cigarette Rod Length on Smokers Switching to SPECTRUM Cigarettes. | Hrabovsky SM et al. | β | 2019 | β |
| Effect of nicotine 6βmg gum on urges to smoke, a randomized clinical trial. | Hansson A et al. | β | 2019 | β |
| Efflux transport of nicotine, cotinine and trans-3'-hydroxycotinine glucuronides by human hepatic transporters. | JΓ€rvinen E et al. | β | 2019 | β |
| Individual-level behavioural smoking cessation interventions tailored for disadvantaged socioeconomic position: a systematic review and meta-regression. | Kock L et al. | β | 2019 | β |
| Lessons on Addiction Messages From "The Real Cost" Campaign. | Roditis ML et al. | β | 2019 | β |
| Phytochemicals for Improving Aspects of Cognitive Function and Psychological State Potentially Relevant to Sports Performance. | Kennedy DO | β | 2019 | β |
| Smoking-associated DNA methylation changes: no smoke without fire. | Herceg Z et al. | β | 2019 | β |
| The Role of Compensation in Nicotine Reduction. | Benowitz NL et al. | β | 2019 | β |
| Tobacco Use in Fibromyalgia Is Associated With Cognitive Dysfunction: A Prospective Questionnaire Study. | Ge L et al. | β | 2019 | β |
| A Comparison of Direct and Indirect Analytical Approaches to Measuring Total Nicotine Equivalents in Urine. | Taghavi T et al. | β | 2018 | β |
| Acute effects of inhaled menthol on the rewarding effects of intravenous nicotine in smokers. | Valentine GW et al. | β | 2018 | β |
| Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population. | Liu Q et al. | β | 2018 | β |
| Behavioral and Biochemical Impact of Chronic Unpredictable Mild Stress on the Acquisition of Nicotine Conditioned Place Preference in Rats. | Biala G et al. | β | 2018 | β |
| Cardiovascular Safety of Varenicline, Bupropion, and Nicotine Patch in Smokers: A Randomized Clinical Trial. | Benowitz NL et al. | β | 2018 | β |
| Cigarette smoking is associated with an altered vaginal tract metabolomic profile. | Nelson TM et al. | β | 2018 | β |
| CYP2A6 metabolism in the development of smoking behaviors in young adults. | Olfson E et al. | β | 2018 | β |
| Evaluation of Nicotine Pharmacokinetics and Subjective Effects following Use of a Novel Nicotine Delivery System. | Teichert A et al. | β | 2018 | β |
| Exposure to workplace smoking bans and continuity of daily smoking patterns on workdays and weekends. | Dunbar MS et al. | β | 2018 | β |
| Impacts of cannabinoid receptor ligands on nicotine- and chronic mild stress-induced cognitive and depression-like effects in mice. | Pekala K et al. | β | 2018 | β |
| Mirtazapine attenuates nicotine-seeking behavior in rats. | Barbosa-MΓ©ndez S et al. | β | 2018 | β |
| Repeated Administration of Cigarette Smoke Condensate Increases Glutamate Levels and Behavioral Sensitization. | Ryu IS et al. | β | 2018 | β |
| Self-Reported Smoking, Urine Cotinine, and Risk of Cardiovascular Disease: Findings From the PREVEND (Prevention of Renal and Vascular End-Stage Disease) Prospective Cohort Study. | Kunutsor SK et al. | β | 2018 | β |
| Smoking resumption after heart or lung transplantation: a systematic review and suggestions for screening and management. | Hofmann P et al. | β | 2018 | β |
| Status and Future Directions of Preclinical Behavioral Pharmacology in Tobacco Regulatory Science. | LeSage MG et al. | β | 2018 | β |
| The epidemiology of lung cancer. | de Groot PM et al. | β | 2018 | β |
| The thalamo-cortical resting state functional connectivity and abstinence-induced craving in young smokers. | Wang C et al. | β | 2018 | β |
| Cardiovascular effects of electronic cigarettes. | Benowitz NL et al. | β | 2017 | β |
| Combination nicotine replacement therapy: strategies for initiation and tapering. | Hsia SL et al. | β | 2017 | β |
| Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6Β Hz-induced psychomotor seizures in mice. | Tutka P et al. | β | 2017 | β |
| Detrimental effects of nicotine on thioacetamide-induced liver injury in mice. | Zhou Z et al. | β | 2017 | β |
| Effect of UGT2B10, UGT2B17, FMO3, and OCT2 genetic variation on nicotine and cotinine pharmacokinetics and smoking in African Americans. | Taghavi T et al. | β | 2017 | β |
| Inhalation of Alcohol Vapor: Measurement and Implications. | MacLean RR et al. | β | 2017 | β |
| Intergrative metabolomic and transcriptomic analyses unveil nutrient remobilization events in leaf senescence of tobacco. | Li W et al. | β | 2017 | β |
| Mirtazapine attenuates the expression of nicotine-induced locomotor sensitization in rats. | Barbosa-MΓ©ndez S et al. | β | 2017 | β |
| Overview of Electronic Nicotine Delivery Systems: A Systematic Review. | Glasser AM et al. | β | 2017 | β |
| Prevalence and Perceptions of Electronic Cigarette Use during Pregnancy. | Wagner NJ et al. | β | 2017 | β |
| Quit Intentions Moderate Subjective and Physiological Responses to Acute Nicotine Replacement Therapy Administration in Dependent Smokers. | Schlagintweit HE et al. | β | 2017 | β |
| Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population. | Wen L et al. | β | 2017 | β |
| Tobacco use disorder and treatment: new challenges and opportunities. | Ziedonis D et al. | β | 2017 | β |
| Validation of Self-reported Smoking with Urinary Cotinine Levels and Influence of Second-hand Smoke among Conscripts. | Chiu YL et al. | β | 2017 | β |
| Varenicline enhances oxidized LDL uptake by increasing expression of LOX-1 and CD36 scavenger receptors through Ξ±<sub>7</sub> nAChR in macrophages. | Kanaoka Y et al. | β | 2017 | β |
| Accidental ingestion of E-cigarette liquid nicotine in a 15-month-old child: an infant mortality case of nicotine intoxication. | Seo AD et al. | β | 2016 | β |
| Appeal of electronic cigarettes in smokers with serious mental illness. | Pratt SI et al. | β | 2016 | β |
| A study of pyrazines in cigarettes and how additives might be used to enhance tobacco addiction. | Alpert HR et al. | β | 2016 | β |
| Characteristics of American Indian/Alaskan Native Quitline Callers Across 14 States. | Lukowski AV et al. | β | 2016 | β |
| Counseling Women on Smoking Relapse Prevention During Postpartum. | Feeney A et al. | β | 2016 | β |
| Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. | Wen L et al. | β | 2016 | β |
| Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction. | Kutlu MG et al. | β | 2016 | β |
| Higher stimulus control is associated with less cigarette intake in daily smokers. | Ferguson SG et al. | β | 2016 | β |
| Pharmacokinetic Drug Interactions with Tobacco, Cannabinoids and Smoking Cessation Products. | Anderson GD et al. | β | 2016 | β |
| Physician Advice to Adolescents About Smoking: Who Gets Advised and Who Benefits Most? | Clawson AH et al. | β | 2016 | β |
| Smoking Prevalence and Its Clinical Correlations in Patients with Narcolepsy-cataplexy. | PeΕinovΓ‘ P et al. | β | 2016 | β |
| SNPs in NRXN1 and CHRNA5 are associated to smoking and regulation of GABAergic and glutamatergic pathways. | PΓ©rez-Rubio G et al. | β | 2016 | β |
| The Health Effects of Electronic Cigarettes. | Dinakar C et al. | β | 2016 | β |
| Time controlled pulsatile transdermal delivery of nicotine: A phase I feasibility trial in male smokers. | Hammann F et al. | β | 2016 | β |
| Tobacco nitrosamines as culprits in disease: mechanisms reviewed. | Yalcin E et al. | β | 2016 | β |
| Atorvastatin improves Y-maze learning behaviour in nicotine treated male albino rats. | Das S S et al. | β | 2015 | β |
| Commonly used stimulants: Sleep problems, dependence and psychological distress. | Ogeil RP et al. | β | 2015 | β |
| Cue reactivity in converted and native intermittent smokers. | Shiffman S et al. | β | 2015 | β |
| Does laboratory cue reactivity correlate with real-world craving and smoking responses to cues? | Shiffman S et al. | β | 2015 | β |
| Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice. | Alsharari SD et al. | β | 2015 | β |
| Establishment of the MethyLight Assay for Assessing Aging, Cigarette Smoking, and Alcohol Consumption. | Endo K et al. | β | 2015 | β |
| Lung cancer screening-why do it? Tobacco, the history of screening, and future challenges. | de Groot PM et al. | β | 2015 | β |
| Nondaily smokers' experience of craving on days they do not smoke. | Shiffman S et al. | β | 2015 | β |
| Pharmacogenetics of nicotine and associated smoking behaviors. | Tanner JA et al. | β | 2015 | β |
| Predictors of the nicotine reinforcement threshold, compensation, and elasticity of demand in a rodent model of nicotine reduction policy. | Grebenstein PE et al. | β | 2015 | β |
| Profile of women who carried out smoking cessation treatment: a systematic review. | Pereira CF et al. | β | 2015 | β |
| Reduced frontal cortical thickness and increased caudate volume within fronto-striatal circuits in young adult smokers. | Li Y et al. | β | 2015 | β |
| Smoking cessation during pregnancy and relapse after childbirth in Canada. | Gilbert NL et al. | β | 2015 | β |
| Stimulus control in intermittent and daily smokers. | Shiffman S et al. | β | 2015 | β |
| The impact of anticipated and unanticipated smoking opportunities on cigarette smoking and nicotine lozenge responses. | Schlagintweit HE et al. | β | 2015 | β |
| The lingering question of menthol in cigarettes. | Besaratinia A et al. | β | 2015 | β |
| Abnormal white matter integrity in the corpus callosum among smokers: tract-based spatial statistics. | Umene-Nakano W et al. | β | 2014 | β |
| Clinical pharmacist's role in implementing a smoking cessation intervention in a Swiss regional hospital: an exploratory study. | Dobrinas M et al. | β | 2014 | β |
| Clinical pharmacology research strategy for dissolvable tobacco products. | Mishina EV et al. | β | 2014 | β |
| Complex suicide with homemade nicotine patches. | Lardi C et al. | β | 2014 | β |
| Conceptualizing analyses of ecological momentary assessment data. | Shiffman S | β | 2014 | β |
| Do ethnicity and gender moderate the influence of posttraumatic stress disorder on time to smoking lapse? | Wilson SM et al. | β | 2014 | β |
| Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice. | Bagdas D et al. | β | 2014 | β |
| Effects of oxytocin on nicotine withdrawal in rats. | Manbeck KE et al. | β | 2014 | β |
| Electronic cigarettes. A position statement of the forum of international respiratory societies. | Schraufnagel DE et al. | β | 2014 | β |
| Emerging nicotine delivery products. Implications for public health. | Benowitz NL | β | 2014 | β |
| Enhanced nicotine metabolism in HIV-1-positive smokers compared with HIV-negative smokers: simultaneous determination of nicotine and its four metabolites in their plasma using a simple and sensitive electrospray ionization liquid chromatography-tandem mass spectrometry technique. | Earla R et al. | β | 2014 | β |
| Examining vulnerability to smokeless tobacco use among adolescents and adults meeting diagnostic criteria for major depressive disorder. | Redner R et al. | β | 2014 | β |
| Inhibitory control dysfunction in nicotine dependence and the influence of short-term abstinence. | Charles-Walsh K et al. | β | 2014 | β |
| Open label smoking cessation with varenicline is associated with decreased glutamate levels and functional changes in anterior cingulate cortex: preliminary findings. | Wheelock MD et al. | β | 2014 | β |
| Rational design of novel CYP2A6 inhibitors. | Tani N et al. | β | 2014 | β |
| Smoking patterns and stimulus control in intermittent and daily smokers. | Shiffman S et al. | β | 2014 | β |
| Targeting the interaction between fatty acid ethanolamides and nicotinic receptors: therapeutic perspectives. | Melis M et al. | β | 2014 | β |
| The impact of nicotine lozenges and stimulus expectancies on cigarette craving. | Schlagintweit HE et al. | β | 2014 | β |
| Tobacco harm reduction: the need for new products that can compete with cigarettes. | FagerstrΓΆm KO et al. | β | 2014 | β |
| Tobacco smoke-induced lung fibrosis and emphysema. | Morse D et al. | β | 2014 | β |
| Transient suppression of late-stage neuronal progenitor cell differentiation in the hippocampal dentate gyrus of rat offspring after maternal exposure to nicotine. | Ohishi T et al. | β | 2014 | β |
| Treatment with a nicotine vaccine does not lead to changes in brain activity during smoking cue exposure or a working memory task. | Havermans A et al. | β | 2014 | β |
| AANA journal course: update for nurse anesthetists--Part3--Tobacco smoking using a waterpipe (hookah): what you need to know. | Eissenberg T | β | 2013 | β |
| Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia. | Wallace TL et al. | β | 2013 | β |
| Behavioral characteristics and pharmacological manipulations of a nicotine-entrainable circadian oscillator. | Gillman AG et al. | β | 2013 | β |
| Behavioral effects of combined environmental enrichment and chronic nicotine administration in male NMRI mice. | Mesa-Gresa P et al. | β | 2013 | β |
| DNA methylation as a long-term biomarker of exposure to tobacco smoke. | Shenker NS et al. | β | 2013 | β |
| Dopaminergic involvement in effort-based but not impulsive reward processing in smokers. | Freeman TP et al. | β | 2013 | β |
| Effects of nicotine on electroencephalographic (EEG) and behavioural measures of visual working memory in non-smokers during a dual-task paradigm. | Fisher DJ et al. | β | 2013 | β |
| Genetic background influences the effects of withdrawal from chronic nicotine on learning and high-affinity nicotinic acetylcholine receptor binding in the dorsal and ventral hippocampus. | Wilkinson DS et al. | β | 2013 | β |
| Increased pain in response to mechanical or thermal stimulation in a rat model of incision-induced pain with nicotine dependence and withdrawal. | Zhang Z et al. | β | 2013 | β |
| Knowledge and beliefs about smoking and goals for smoking cessation in hospitalized men with cardiovascular disease. | Elshatarat RA et al. | β | 2013 | β |
| Mesolimbic dopamine and habenulo-interpeduncular pathways in nicotine withdrawal. | Dani JA et al. | β | 2013 | β |
| Neuropsychiatric adverse events of varenicline: a systematic review of published reports. | Ahmed AI et al. | β | 2013 | β |
| Nicotine metabolism and addiction among adolescent smokers. | Rubinstein ML et al. | β | 2013 | β |
| Nicotine related brain activity: the influence of smoking history and blood nicotine levels, an exploratory study. | Yamamoto RT et al. | β | 2013 | β |
| Not so Cool? Menthol's discovered actions on the nicotinic receptor and its implications for nicotine addiction. | Kabbani N | β | 2013 | β |
| Pharmacological interventions for smoking cessation: an overview and network meta-analysis. | Cahill K et al. | β | 2013 | β |
| Predictors of weight change in sedentary smokers receiving a standard smoking cessation intervention. | Prod'hom S et al. | β | 2013 | β |
| Race, gender, and nicotine metabolism in adolescent smokers. | Rubinstein ML et al. | β | 2013 | β |
| Reduced nicotine content cigarettes and nicotine patch. | Hatsukami DK et al. | β | 2013 | β |
| (R)-nicotine biosynthesis, metabolism and translocation in tobacco as determined by nicotine demethylase mutants. | Cai B et al. | β | 2013 | β |
| Smoking cessation in community pharmacy practice-a clinical information needs analysis. | Saba M et al. | β | 2013 | β |
| The cannabinoid CB2 receptor is necessary for nicotine-conditioned place preference, but not other behavioral effects of nicotine in mice. | Ignatowska-Jankowska BM et al. | β | 2013 | β |
| The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence. | Nunes SO et al. | β | 2013 | β |
| Ξ²-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice. | Iskandar AR et al. | β | 2013 | β |
| Adolescent cigarette smokers' and non-cigarette smokers' use of alternative tobacco products. | Saunders C et al. | β | 2012 | β |
| Association between tobacco smoking and cognitive functioning in young adults. | Chamberlain SR et al. | β | 2012 | β |
| Brain grey matter deficits in smokers: focus on the cerebellum. | KΓΌhn S et al. | β | 2012 | β |
| Delivery of nicotine in an extract of a smokeless tobacco product reduces its reinforcement-attenuating and discriminative stimulus effects in rats. | Harris AC et al. | β | 2012 | β |
| Efficacy of a nicotine mouth spray in smoking cessation: a randomised, double-blind trial. | TΓΈnnesen P et al. | β | 2012 | β |
| Exploring the relationships between tobacco smoking and schizophrenia in first-degree relatives. | Ferchiou A et al. | β | 2012 | β |
| Joint effects of smoking and gene variants involved in sex steroid metabolism on hot flashes in late reproductive-age women. | Butts SF et al. | β | 2012 | β |
| Low dose nicotine and antagonism of Ξ²2 subunit containing nicotinic acetylcholine receptors have similar effects on affective behavior in mice. | Anderson SM et al. | β | 2012 | β |
| Nicotine vaccines to assist with smoking cessation: current status of research. | Raupach T et al. | β | 2012 | β |
| Occupational gradients in smoking behavior and exposure to workplace environmental tobacco smoke: the multi-ethnic study of atherosclerosis. | Fujishiro K et al. | β | 2012 | β |
| Pharmacogenetics of smoking cessation: role of nicotine target and metabolism genes. | Gold AB et al. | β | 2012 | β |
| Racial differences in hair nicotine concentrations among smokers. | Apelberg BJ et al. | β | 2012 | β |
| Rationale and consequences of reclassifying obesity as an addictive disorder: neurobiology, food environment and social policy perspectives. | Allen PJ et al. | β | 2012 | β |
| Reproducibility of the nicotine metabolite ratio in cigarette smokers. | St Helen G et al. | β | 2012 | β |
| Smoking cessation intervention in a cardiovascular hospital based clinical setting. | Samaan Z et al. | β | 2012 | β |
| Stress-induced activation of the dynorphin/ΞΊ-opioid receptor system in the amygdala potentiates nicotine conditioned place preference. | Smith JS et al. | β | 2012 | β |
| Structure-activity studies of 7-heteroaryl-3-azabicyclo[3.3.1]non-6-enes: a novel class of highly potent nicotinic receptor ligands. | Breining SR et al. | β | 2012 | β |
| The reinforcement threshold for nicotine as a target for tobacco control. | Sofuoglu M et al. | β | 2012 | β |
| Tobacco dependence among intermittent smokers. | Shiffman S et al. | β | 2012 | β |
| Toxicity of amphetamines: an update. | Carvalho M et al. | β | 2012 | β |
| Trajectories of cigarette smoking in adulthood predict insomnia among women in late mid-life. | Brook DW et al. | β | 2012 | β |
| Varenicline dose dependently enhances responding for nonpharmacological reinforcers and attenuates the reinforcement-enhancing effects of nicotine. | Levin ME et al. | β | 2012 | β |
| Varenicline-induced psychotic depressive episode in a patient with bipolar disorder. | Annagur BB et al. | β | 2012 | β |
| A lack of association between severity of nicotine withdrawal and individual differences in compensatory nicotine self-administration in rats. | Harris AC et al. | β | 2011 | β |
| A manic episode in a 64-year-old man: an adverse effect of varenicline. | Ahmed AI | β | 2011 | β |
| Association between time to first cigarette after waking up and salivary cotinine concentration. | Fu M et al. | β | 2011 | β |
| Association of CHRNA4 polymorphisms with smoking behavior in two populations. | Han S et al. | β | 2011 | β |
| Association of daily tar and nicotine intake with incident myocardial infarction: results from the population-based MONICA/KORA Augsburg Cohort Study 1984-2002. | Zhang QL et al. | β | 2011 | β |
| Determination of the nicotine metabolites cotinine and trans-3'-hydroxycotinine in biologic fluids of smokers and non-smokers using liquid chromatography-tandem mass spectrometry: biomarkers for tobacco smoke exposure and for phenotyping cytochrome P450 2A6 activity. | Jacob P et al. | β | 2011 | β |
| Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers. | Breitling LP et al. | β | 2011 | β |
| Effects of smoking and smoking cessation on life expectancy in an elderly population in Beijing, China, 1992-2000: an 8-year follow-up study. | Tian X et al. | β | 2011 | β |
| Lapse-induced surges in craving influence relapse in adult smokers: an experimental investigation. | Shadel WG et al. | β | 2011 | β |
| Menthol cigarette smoking and nicotine dependence. | Hoffman AC et al. | β | 2011 | β |
| Menthol's potential effects on nicotine dependence: a tobacco industry perspective. | Yerger VB | β | 2011 | β |
| Neurophysiology of Nicotine Addiction. | Dani JA et al. | β | 2011 | β |
| Nicotine conjugate vaccine as a novel approach to smoking cessation. | Ottney AR | β | 2011 | β |
| P50 sensory gating and smoking in the general population. | Brinkmeyer J et al. | β | 2011 | β |
| [Pharmacotherapeutic treatment strategies for smoking cessation]. | Vasic N et al. | β | 2011 | β |
| Prompt but inefficient: nicotine differentially modulates discrete components of attention. | Vangkilde S et al. | β | 2011 | β |
| Quantification of nicotine, cotinine, trans-3'-hydroxycotinine and varenicline in human plasma by a sensitive and specific UPLC-tandem mass-spectrometry procedure for a clinical study on smoking cessation. | Dobrinas M et al. | β | 2011 | β |
| Reward, addiction, withdrawal to nicotine. | De Biasi M et al. | β | 2011 | β |
| Sexually diergic hypothalamic-pituitary-adrenal (HPA) responses to single-dose nicotine, continuous nicotine infusion, and nicotine withdrawal by mecamylamine in rats. | Gentile NE et al. | β | 2011 | β |
| Single-dose pharmacokinetics of nicotine when given with a novel mouth spray for nicotine replacement therapy. | Kraiczi H et al. | β | 2011 | β |
| Smoking cessation: crucial to target women as well as men. | Steliga MA et al. | β | 2011 | β |
| Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine. | Carroll FI et al. | β | 2011 | β |
| The German multi-centre study on smoking-related behavior-description of a population-based case-control study. | Lindenberg A et al. | β | 2011 | β |
| The health effects of menthol cigarettes as compared to non-menthol cigarettes. | Hoffman AC | β | 2011 | β |
| The serotonin transporter gene and startle response during nicotine deprivation. | Minnix JA et al. | β | 2011 | β |
| Tobacco-smoking-related differential DNA methylation: 27K discovery and replication. | Breitling LP et al. | β | 2011 | β |
| Transdermal nicotine replacement therapy in cigarette smokers with acute subarachnoid hemorrhage. | Seder DB et al. | β | 2011 | β |
| Vaccination against nicotine alters the distribution of nicotine delivered via cigarette smoke inhalation to rats. | Pravetoni M et al. | β | 2011 | β |
| Waterpipe tobacco smoking and cigarette smoking: a direct comparison of toxicant exposure and subjective effects. | Cobb CO et al. | β | 2011 | β |
| Why do young women smoke? VI. A controlled study of nicotine effects on attention: pharmacogenetic interactions. | Rigbi A et al. | β | 2011 | β |
| Within-day temporal patterns of smoking, withdrawal symptoms, and craving. | Chandra S et al. | β | 2011 | β |
| Women and smoking: risks, impacts, and challenges. | Lombardi EM et al. | β | 2011 | β |
| Adverse childhood experiences are associated with the risk of lung cancer: a prospective cohort study. | Brown DW et al. | β | 2010 | β |
| Assessing the accuracy of self-reported smoking status and impact of passive smoke exposure among pregnant Aboriginal and Torres Strait Islander women using cotinine biochemical validation. | Gilligan C et al. | β | 2010 | β |
| Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction. | Mobascher A et al. | β | 2010 | β |
| Biomonitoring of smoke constituents: exposure to 4-aminobiphenyl and 4-aminobiphenyl hemoglobin adduct levels in nonsmokers and smokers. | Schorp MK et al. | β | 2010 | β |
| Challenges of treating asthma in people who smoke. | Spears M et al. | β | 2010 | β |
| Comparison of the behavioral effects of cigarette smoke and pure nicotine in rats. | Harris AC et al. | β | 2010 | β |
| Confronting a neglected epidemic: tobacco cessation for persons with mental illnesses and substance abuse problems. | Schroeder SA et al. | β | 2010 | β |
| Cotinine-assessed second-hand smoke exposure and risk of cardiovascular disease in older adults. | Jefferis BJ et al. | β | 2010 | β |
| Death due to ingestion of nicotine-containing solution: case report and review of the literature. | Solarino B et al. | β | 2010 | β |
| Dipstick tests for secondhand smoke exposure. | Best D et al. | β | 2010 | β |
| Genetic variation in nicotine metabolism predicts the efficacy of extended-duration transdermal nicotine therapy. | Lerman C et al. | β | 2010 | β |
| Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling. | Yamazaki H et al. | β | 2010 | β |
| Low-to-moderate alcohol consumption and smoking cessation rates: retrospective analysis of 4576 elderly ever-smokers. | Breitling LP et al. | β | 2010 | β |
| Menthol cigarettes contribute to the appeal and addiction potential of smoking for youth. | Hersey JC et al. | β | 2010 | β |
| Multidrug poisoning involving nicotine and tramadol. | Solarino B et al. | β | 2010 | β |
| Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. | Berrendero F et al. | β | 2010 | β |
| Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons. | Biegon A et al. | β | 2010 | β |
| Nicotine reduction revisited: science and future directions. | Hatsukami DK et al. | β | 2010 | β |
| Nicotinic acetylcholine receptor efficacy and pharmacological properties of 3-(substituted phenyl)-2Ξ²-substituted tropanes. | Carroll FI et al. | β | 2010 | β |
| Pharmacogenetics of smoking cessation therapy. | Kortmann GL et al. | β | 2010 | β |
| Reduced thickness of medial orbitofrontal cortex in smokers. | KΓΌhn S et al. | β | 2010 | β |
| Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance. | Winterer G et al. | β | 2010 | β |
| Route of nicotine administration influences in vivo dopamine neuron activity: habituation, needle injection, and cannula infusion. | Dong Y et al. | β | 2010 | β |
| Sexually diergic, dose-dependent hypothalamic-pituitary-adrenal axis responses to nicotine in a dynamic in vitro perfusion system. | McKlveen JM et al. | β | 2010 | β |
| Smoking, nicotine and neuropsychiatric disorders. | Dome P et al. | β | 2010 | β |
| Smoking resumption after lung transplantation: a sobering truth. | Vos R et al. | β | 2010 | β |
| Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation. | Carroll FI et al. | β | 2010 | β |
| The P300 event-related potential and smoking--a population-based case-control study. | Mobascher A et al. | β | 2010 | β |
| The pituri story: a review of the historical literature surrounding traditional Australian Aboriginal use of nicotine in Central Australia. | Ratsch A et al. | β | 2010 | β |
| Use of cigarettes to improve affect and depressive symptoms in a longitudinal study of adolescents. | Chaiton M et al. | β | 2010 | β |
| Varenicline use in patients with mental illness: an update of the evidence. | Purvis TL et al. | β | 2010 | β |
| Alkaloids toxic to livestock. | Molyneux RJ et al. | β | 2009 | β |
| A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo. | Al Koudsi N et al. | β | 2009 | β |
| Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the Fawn-Hooded rat, an animal model of co-morbid depression and alcoholism. | Tizabi Y et al. | β | 2009 | β |
| Association between anxiety and smoking in a sample of urban black men. | Collins BN et al. | β | 2009 | β |
| Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans. | Breitling LP et al. | β | 2009 | β |
| A tragic triad: coronary artery disease, nicotine addiction, and depression. | Thorndike AN et al. | β | 2009 | β |
| Biomarkers of abdominal aortic aneurysm progression. Part 2: inflammation. | Hellenthal FA et al. | β | 2009 | β |
| Brain fMRI reactivity to smoking-related images before and during extended smoking abstinence. | Janes AC et al. | β | 2009 | β |
| Changes in environmental tobacco smoke (ETS) exposure over a 20-year period: cross-sectional and longitudinal analyses. | Jefferis BJ et al. | β | 2009 | β |
| Correlates of individual differences in compensatory nicotine self-administration in rats following a decrease in nicotine unit dose. | Harris AC et al. | β | 2009 | β |
| Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. | Greenbaum L et al. | β | 2009 | β |
| Dopamine genes and nicotine dependence in treatment-seeking and community smokers. | Bergen AW et al. | β | 2009 | β |
| Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine. | Zhang T et al. | β | 2009 | β |
| Drug delivery in the twenty-first century: a new paradigm. | Smith B et al. | β | 2009 | β |
| Family support and employment as predictors of smoking cessation success: a randomized, double-blind, placebo-controlled trial of nicotine sublingual tablets in chinese smokers. | Sun HQ et al. | β | 2009 | β |
| Moving forward in smoking cessation: issues for psychiatric nurses. | Schroeder SA | β | 2009 | β |
| New operant model of nicotine-seeking behaviour in mice. | MartΓn-GarcΓa E et al. | β | 2009 | β |
| Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes. | Ray R et al. | β | 2009 | β |
| Nicotine exposure during adolescence induces a depression-like state in adulthood. | IΓ±iguez SD et al. | β | 2009 | β |
| Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: a validation study. | Schnoll RA et al. | β | 2009 | β |
| Polymorphism of human cytochrome P450 enzymes and its clinical impact. | Zhou SF et al. | β | 2009 | β |
| Real world study to evaluate the effectiveness of varenicline and cognitive-behavioural interventions for smoking cessation. | Ramon JM et al. | β | 2009 | β |
| Sequencing of DSM-IV criteria of nicotine dependence. | Kandel DB et al. | β | 2009 | β |
| Similarities in food cravings and mood states between obese women and women who smoke tobacco. | Pepino MY et al. | β | 2009 | β |
| Smoking cessation and variations in nicotinic acetylcholine receptor subunits alpha-5, alpha-3, and beta-4 genes. | Breitling LP et al. | β | 2009 | β |
| Smoking induced worsening of dystonia. A case report. | Prashantha DK et al. | β | 2009 | β |
| Ten critical reasons for treating tobacco dependence in inpatient psychiatry. | Prochaska JJ | β | 2009 | β |
| The neuropharmacological substrates of nicotine reward: reinforcing versus reinforcement-enhancing effects of nicotine. | Paterson NE | β | 2009 | β |
| Time to first cigarette after waking predicts cotinine levels. | Muscat JE et al. | β | 2009 | β |
| Tobacco smoke affects expression of peroxisome proliferator-activated receptor-gamma in monocyte/macrophages of patients with coronary heart disease. | Amoruso A et al. | β | 2009 | β |
| Why won't our patients stop smoking? The power of nicotine addiction. | Mannino DM | β | 2009 | β |
| Accuracy of self-reported smoking and secondhand smoke exposure in the US workforce: the National Health and Nutrition Examination Surveys. | Arheart KL et al. | β | 2008 | β |
| CYP2A6 polymorphisms and risk for tobacco-related cancers. | Rossini A et al. | β | 2008 | β |
| Genetic variation in the dopamine pathway and smoking cessation. | David SP et al. | β | 2008 | β |
| Impact of Smoking on the Atrial Substrate Characteristics in Patients with Atrial Fibrillation. | Tuan TC et al. | β | 2008 | β |
| Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. | Conti DV et al. | β | 2008 | β |
| Nicotinic receptor partial agonists as novel compounds for the treatment of smoking cessation. | Tutka P | β | 2008 | β |
| Smoking cessation guidelines--2008. | Reichert J et al. | β | 2008 | β |
| Subpicogram per milliliter determination of the tobacco-specific carcinogen metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine using liquid chromatography-tandem mass spectrometry. | Jacob P et al. | β | 2008 | β |
| Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice. | Fowler CD et al. | β | 2008 | β |