Bidirectional effects of GABAergic agonists and antagonists on maintenance of voluntary ethanol intake in rats.
paper
Cited
Public
Unavailable
- Authors
- Boyle, A E; Segal, R; Smith, B R; Amit, Z
- Year
- 1993
- Journal
- Pharmacology, biochemistry, and behavior
- PMID
- 8255910
- DOI
- 10.1016/0091-3057(93)90338-t
The effects of THIP (GABAA agonist) and picrotoxin (GABA antagonist) on the maintenance of voluntary ethanol ingestion were examined. Thirty-three male Long-Evans rats were initially exposed to a screening procedure in which increasing concentrations of ethanol (from 2% to 9%) were presented in a free choice with water, on an alternate day schedule. Following the screening procedure, the rats were exposed to five ethanol presentations at a concentration of 9%, which constituted the baseline period, and five additional ethanol presentations during which the effects of the GABAergic manipulations were determined (test period). During the test period, the animals received IP injections of either 16 mg/kg of THIP, 2 mg/kg of picrotoxin or saline. The results suggested that the differential GABA manipulations resulted in bidirectional effects on the consumption of ethanol. More specifically, the GABAA agonist THIP increased the intake of ethanol as compared to baseline measures, while the GABA antagonist picrotoxin decreased ethanol intake. Similarly, the administration of THIP increased ethanol preference. In contrast, preference for ethanol over water was decreased following the administration of picrotoxin. It appears that the effects of these GABAergic manipulations are specific to ethanol, since total fluid intake was not influenced by the administration of either drug (i.e., THIP or picrotoxin). In light of the literature suggesting that THIP and picrotoxin are active at different sites within the GABAA chloride-ionophore receptor complex, the present findings would suggest that the GABAA receptor may play a role in regulating the voluntary intake of ethanol.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Ethanol-induced rapid eye movement sleep suppression in rats: Comparison with subtype-selective GABA<sub>A</sub> receptor compounds. | Reeves-Darby JA et al. | β | 2025 | β |
| Opioid use and abuse in adolescents and young adults; dealing with science, laws and ethics: Charming the COBRAS. | Greydanus DE et al. | β | 2025 | β |
| GABAergic compounds for the treatment of alcohol use disorder. | Berro LF et al. | β | 2024 | β |
| The influence of drug class on reward in substance use disorders. | Jones JD et al. | β | 2024 | β |
| The TMEM132B-GABA<sub>A</sub> receptor complex controls alcohol actions in the brain. | Wang G et al. | β | 2024 | β |
| GABRB2, a key player in neuropsychiatric disorders and beyond. | Barki M et al. | β | 2022 | β |
| The serotonin 2A receptor agonist TCB-2 attenuates heavy alcohol drinking and alcohol-induced midbrain inhibitory plasticity. | Kimmey BA et al. | β | 2022 | β |
| The Role of the Central Amygdala in Alcohol Dependence. | Roberto M et al. | β | 2021 | β |
| Excitatory/inhibitory balance across ontogeny contributes to age-specific behavioral outcomes of ethanol-like challenge in conditioned taste aversion. | Dannenhoffer CA et al. | β | 2019 | β |
| Adolescent Nicotine Exposure Alters GABA<sub>A</sub> Receptor Signaling in the Ventral Tegmental Area and Increases Adult Ethanol Self-Administration. | Thomas AM et al. | β | 2018 | β |
| GABA<sub>A</sub> receptor polymorphisms in alcohol use disorder in the GWAS era. | Koulentaki M et al. | β | 2018 | β |
| GABA<sub>A</sub> Receptor Subtype Mechanisms and the Abuse-Related Effects of Ethanol: Genetic and Pharmacological Evidence. | Chandler CM et al. | β | 2018 | β |
| The Cerebellar GABA<sub>A</sub>R System as a Potential Target for Treating Alcohol Use Disorder. | Rossi DJ et al. | β | 2018 | β |
| Synaptic targets: Chronic alcohol actions. | Roberto M et al. | β | 2017 | β |
| Novel candidate genes for alcoholism--transcriptomic analysis of prefrontal medial cortex, hippocampus and nucleus accumbens of Warsaw alcohol-preferring and non-preferring rats. | Stankiewicz AM et al. | β | 2015 | β |
| GABAergic contributions to alcohol responsivity during adolescence: insights from preclinical and clinical studies. | Silveri MM | β | 2014 | β |
| Gamma-aminobutyric acid system genes--no evidence for a role in alcohol use and abuse in a community-based sample. | Irons DE et al. | β | 2014 | β |
| Levetiracetam results in increased and decreased alcohol drinking with different access procedures in C57BL/6J mice. | Fish EW et al. | β | 2014 | β |
| Site-specific microinjection of Gaboxadol into the infralimbic cortex modulates ethanol intake in male C57BL/6J mice. | Fritz BM et al. | β | 2014 | β |
| Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system. | Doyon WM et al. | β | 2013 | β |
| Effect of ganaxolone and THIP on operant and limited-access ethanol self-administration. | Ramaker MJ et al. | β | 2012 | β |
| GABA(A) receptor modulation during adolescence alters adult ethanol intake and preference in rats. | Hulin MW et al. | β | 2012 | β |
| Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. | Gilpin NW et al. | β | 2012 | β |
| The central amygdala and alcohol: role of Ξ³-aminobutyric acid, glutamate, and neuropeptides. | Roberto M et al. | β | 2012 | β |
| Alteration of ethanol drinking in mice via modulation of the GABA(A) receptor with ganaxolone, finasteride, and gaboxadol. | Ramaker MJ et al. | β | 2011 | β |
| Effects of 7-keto dehydroepiandrosterone on voluntary ethanol intake in male rats. | Worrel ME et al. | β | 2011 | β |
| Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. | Nie H et al. | β | 2011 | β |
| Genetic association study of GABRA2 single nucleotide polymorphisms and electroencephalography in alcohol dependence. | Lydall GJ et al. | β | 2011 | β |
| Neurosteroid Binding Sites on the GABA(A) Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence. | Hulin MW et al. | β | 2011 | β |
| Alcoholism and alternative splicing of candidate genes. | Sasabe T et al. | β | 2010 | β |
| Genetics of addictions. | Hartz SM et al. | β | 2010 | β |
| Genetics of addictions. | Hartz SM et al. | β | 2010 | β |
| Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring p rats. | Besheer J et al. | β | 2010 | β |
| The role of the GABAergic and dopaminergic systems in the brain response to an intragastric load of alcohol in conscious rats. | Tsurugizawa T et al. | β | 2010 | β |
| Effects of pregnanolone and dehydroepiandrosterone on ethanol intake in rats administered ethanol or saline during adolescence. | Gurkovskaya OV et al. | β | 2009 | β |
| Plasticity of addiction: a mesolimbic dopamine short-circuit? | Niehaus JL et al. | β | 2009 | β |
| Preclinical evaluation of riluzole: assessments of ethanol self-administration and ethanol withdrawal symptoms. | Besheer J et al. | β | 2009 | β |
| Acute ethanol induces Fos in GABAergic and non-GABAergic forebrain neurons: a double-labeling study in the medial prefrontal cortex and extended amygdala. | Leriche M et al. | β | 2008 | β |
| GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. | Soyka M et al. | β | 2008 | β |
| Neurobiology of addiction. An integrative review. | Goodman A | β | 2008 | β |
| Chronic progesterone treatment augments while dehydroepiandrosterone sulphate prevents tolerance to ethanol anxiolysis and withdrawal anxiety in rats. | Sharma AN et al. | β | 2007 | β |
| GABAergic modulation of binge-like ethanol intake in C57BL/6J mice. | Moore EM et al. | β | 2007 | β |
| The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses. | Matthews AG et al. | β | 2007 | β |
| Effects of gamma-hydroxybutyric acid and flunitrazepam on ethanol intake in male rats. | Leonard ST et al. | β | 2006 | β |
| GABAA receptor regulation of voluntary ethanol drinking requires PKCepsilon. | Besheer J et al. | β | 2006 | β |
| GABA(A) receptor subtypes as targets for neuropsychiatric drug development. | Korpi ER et al. | β | 2006 | β |
| Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. | Drgon T et al. | β | 2006 | β |
| The genetics of alcoholism: identifying specific genes through family studies. | Edenberg HJ et al. | β | 2006 | β |
| Alternative splicing and promoter use in the human GABRA2 gene. | Tian H et al. | β | 2005 | β |
| GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. | Pierucci-Lagha A et al. | β | 2005 | β |
| Comparison of deramciclane to benzodiazepine agonists in behavioural activity of mice and in alcohol drinking of alcohol-preferring rats. | Ingman K et al. | β | 2004 | β |
| Genes associated with addiction: alcoholism, opiate, and cocaine addiction. | Kreek MJ et al. | β | 2004 | β |
| Motor impairing effects of ethanol and diazepam in rats selectively bred for high and low ethanol consumption in a limited-access paradigm. | Shram MJ et al. | β | 2004 | β |
| The effect of baclofen alone and in combination with naltrexone on ethanol consumption in the rat. | Stromberg MF | β | 2004 | β |
| Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. | Edenberg HJ et al. | β | 2004 | β |
| Association of GABA(A) receptors and alcohol dependence and the effects of genetic imprinting. | Song J et al. | β | 2003 | β |
| GABAA receptor alpha 1 and beta 2 subunit null mutant mice: behavioral responses to ethanol. | Blednov YA et al. | β | 2003 | β |
| Plant derivatives in the treatment of alcohol dependency. | Rezvani AH et al. | β | 2003 | β |
| The role of GABAA receptors in mediating the effects of alcohol in the central nervous system. | Davies M | β | 2003 | β |
| Long-lasting potentiation of GABAergic synapses in dopamine neurons after a single in vivo ethanol exposure. | Melis M et al. | β | 2002 | β |
| Ethanol and neurosteroid interactions in the brain. | Morrow AL et al. | β | 2001 | β |
| GABA(A)-receptor delta subunit knockout mice have multiple defects in behavioral responses to ethanol. | Mihalek RM et al. | β | 2001 | β |
| The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. | Morrow AL et al. | β | 2001 | β |
| Alcohol alliesthesia: food restriction increases the palatability of alcohol through a corticosterone-dependent mechanism. | SΓΆderpalm AH et al. | β | 1999 | β |
| Baclofen alters ethanol-stimulated activity but not conditioned place preference or taste aversion in mice. | Chester JA et al. | β | 1999 | β |
| Effect of pentylenetetrazole on ethanol intake, ethanol kinetics, and social behavior in male Wistar rats. | Buczek Y et al. | β | 1998 | β |
| A role for chloride in the suppressive effect of acetylcholine on afferent vestibular activity. | Pantoja AM et al. | β | 1997 | β |
| Opposite effects of Ro 15-4513 on acquisition and maintenance of ethanol drinking behavior in male Wistar rats. | Buczek Y et al. | β | 1997 | β |
| Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats. | Roberts AJ et al. | β | 1996 | β |
| Pharmacotherapies for alcohol problems: a review of research with focus on developments since 1991. | Litten RZ et al. | β | 1996 | β |
| From ion currents to genomic analysis: recent advances in GABAA receptor research. | Rabow LE et al. | β | 1995 | β |
| GABAA receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. | HyytiΓ€ P et al. | β | 1995 | β |
| Median and dorsal raphe injections of the 5-HT1A agonist, 8-OH-DPAT, and the GABAA agonist, muscimol, increase voluntary ethanol intake in Wistar rats. | Tomkins DM et al. | β | 1994 | β |