Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.
paper
Cited
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- Authors
- Cui, Ri; Kamatani, Yoichiro; Takahashi, Atsushi; Usami, Masayuki; Hosono, Naoya; Kawaguchi, Takahisa; Tsunoda, Tatsuhiko; Kamatani, Naoyuki; Kubo, Michiaki; Nakamura, Yusuke; Matsuda, Koichi
- Year
- 2009
- Journal
- Gastroenterology
- PMID
- 19698717
- DOI
- 10.1053/j.gastro.2009.07.070
BACKGROUND & AIMS: Esophageal squamous cell carcinoma (ESCC) is prevalent among Asian populations, with marked regional variations in incidence and mortality. Patients with ESCC have a very poor prognosis, but detection of ESCC at earlier stages could improve clinical outcome. Therefore, identification of epidemiologic factors that influence the development of ESCC would facilitate prevention and/or early detection of the disease. METHODS: We performed a 2-step genome-wide association study with subsequent replication analysis using a total of 1070 Japanese ESCC cases and 2836 controls. We also used logistic regression analysis to estimate the effect of gene-gene and gene-environmental interactions. RESULTS: We identified the significant associations of ESCC with 4q21-23 and 12q24 regions, which include nonsynonymous single nucleotide polymorphisms (SNP) in ADH1B (rs1229984, P = 6.76 x 10(-35)) and ALDH2 (rs671, P = 3.68 x 10(-68)) that were previously shown to be associated with ESCC susceptibility. Multiple logistic regression analysis revealed SNP rs671, rs1229984, alcohol drinking, and smoking as the independent risk factors for ESCC (odds ratios of 1.66, 1.85, 1.92, and 1.79, respectively). Moreover, individuals who had both genetic and lifestyle-related risk factors had a nearly 190 times higher risk of ESCC than those who had neither of these. CONCLUSIONS: We found 2 known functional variants involved in the metabolism of alcohol and tobacco by-products as the most significant risk factors for the development of ESCC in a Japanese population. The individuals carrying both risk genotypes have a higher baseline risk of ESCC that is substantially increased by 2 lifestyle risk factors.
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|---|---|---|---|---|
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| Does the alcohol flushing response modify the relationship between alcohol consumption and the risk of developing osteonecrosis of the femoral head? A multicenter case-control study in Japan. | Tani T et al. | β | 2026 | β |
| Genetic risk stratification and preventive strategies for double primary HNSCC and ESCC: a single-center cohort study. | Naito S et al. | β | 2026 | β |
| Global burden of smoking-attributable digestive cancers from 1990 to 2021: insights from the Global Burden of Disease study. | Zi M et al. | β | 2026 | β |
| ALDH2 Deficiency and Alcohol Intake in the United States: Opportunity for Precision Cancer Prevention. | Forman D et al. | β | 2025 | β |
| ALDH2 inhibits angiogenesis in esophageal squamous cell carcinoma by suppressing the NOTCH1/PI3K/Akt signaling pathway. | Qiang J et al. | β | 2025 | β |
| Bioinformatics analysis to identify endocrine-disrupting chemicals targeting key ESCC-related genes. | Zhu Y et al. | β | 2025 | β |
| Cis-Regulatory Alterations in FOXP4 Modulate Esophageal Cancer Susceptibility Induced by Chronic Alcohol Exposure. | Niu S et al. | β | 2025 | β |
| Construction of a novel prognostic model for gastric cancer based on pharmacokinetics-related genes and comprehensive prognostic analysis. | Zhang Y et al. | β | 2025 | β |
| Differential Genetic Architecture of Insulin Resistance (HOMA-IR) Based on Obesity Status: Evidence from a Large-Scale GWAS of Koreans. | Choi JE et al. | β | 2025 | β |
| Gene-based Hardy-Weinberg equilibrium test using genotype count data: application to six types of cancers. | Nishino J et al. | β | 2025 | β |
| Genetic susceptibility of diffuse large B-cell lymphoma: a meta genome-wide association study in Asian population. | Cui Q et al. | β | 2025 | β |
| Global research landscapes of ALDH2 and cancer revealed by bibliometric analysis. | Zhang T et al. | β | 2025 | β |
| High mean corpuscular volume as a predictor of esophageal cancer: A cohort study based on the Japanese Shizuoka Kokuho Database. | Sato S et al. | β | 2025 | β |
| Integrating tumour and lymph node radiomics features for predicting disease-free survival in locally advanced esophageal squamous cell cancer after neoadjuvant chemotherapy and complete resection. | Zhao B et al. | β | 2025 | β |
| Multiple DNA repair pathways prevent acetaldehyde-induced mutagenesis in yeast. | Porcher L et al. | β | 2025 | β |
| Network toxicology reveals collaborative mechanism of 4NQO and ethanol in esophageal squamous cell carcinogenesis. | Yuan J et al. | β | 2025 | β |
| Personalized prediction of esophageal cancer risk based on virtually generated alcohol data. | Nfor ON et al. | β | 2025 | β |
| Somatic mosaicism in the buccal mucosa reflects lifestyle and germline risk factors for esophageal squamous cell carcinoma. | Yokoyama A et al. | β | 2025 | β |
| The Kashima Scan Study 2: a protocol for a prospective observational cohort study of cerebral small vessel disease in neurologically healthy adults. | Suzuyama K et al. | β | 2025 | β |
| Alcohol-associated liver cancer. | Fu Y et al. | β | 2024 | β |
| Alcohol consumption, multiple Lugol-voiding lesions, and field cancerization. | Katada C et al. | β | 2024 | β |
| ALDH2 dysfunction and alcohol cooperate in cancer stem cell enrichment. | Flashner S et al. | β | 2024 | β |
| ALDH2 mutations and defense against genotoxic aldehydes in cancer and inherited bone marrow failure syndromes. | Woo AY et al. | β | 2024 | β |
| Clinicopathological and genomic features of superficial esophageal squamous cell carcinomas in nondrinker, nonsmoker females. | Fukuhara M et al. | β | 2024 | β |
| COL8A1 Regulates Esophageal Squamous Carcinoma Proliferation and Invasion Through PI3K/AKT Pathway. | Hu J et al. | β | 2024 | β |
| Endogenous ethanol production in health and disease. | Meijnikman AS et al. | β | 2024 | β |
| Genetic architecture of alcohol consumption identified by a genotype-stratified GWAS and impact on esophageal cancer risk in Japanese people. | Koyanagi YN et al. | β | 2024 | β |
| HiChIP-Based Epigenomic Footprinting Identifies a Promoter Variant of UXS1 That Confers Genetic Susceptibility to Gastroesophageal Cancer. | Gnanapragasam A et al. | β | 2024 | β |
| Metformin in Esophageal Carcinoma: Exploring Molecular Mechanisms and Therapeutic Insights. | Papadakos SP et al. | β | 2024 | β |
| Prediction of esophageal cancer risk based on genetic variants and environmental risk factors in Chinese population. | Liu H et al. | β | 2024 | β |
| Roles of long nonβcoding RNA SNHG16 in human digestive system cancer (Review). | Zhao L et al. | β | 2024 | β |
| Aldehyde dehydrogenase in solid tumors and other diseases: Potential biomarkers and therapeutic targets. | Xia J et al. | β | 2023 | β |
| Bioinformatics and network pharmacology identify promotional effects and potential mechanisms of ethanol on esophageal squamous cell carcinoma and experimental validation. | Huang M et al. | β | 2023 | β |
| Comparative transcriptome characterization of esophageal squamous cell carcinoma and adenocarcinoma. | Li X et al. | β | 2023 | β |
| Effects of activation of an alcohol metabolic gene, cigarette smoking, and alcohol intake on the incidence of metachronous gastric cancer in patients who underwent endoscopic resection for gastric cancer: A multicenter retrospective pilot study. | Abiko S et al. | β | 2023 | β |
| Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model. | Mu A et al. | β | 2023 | β |
| Exploring the genetic diversity of the Japanese population: Insights from a large-scale whole genome sequencing analysis. | Kawai Y et al. | β | 2023 | β |
| Exploring the genetic diversity of the Japanese Population: Insights from a Large-Scale Whole Genome Sequencing Analysis | Kawai Y et al. | β | 2023 | β |
| Genome-wide association study of esophageal squamous cell cancer identifies shared and distinct risk variants in African and Chinese populations. | Chen WC et al. | β | 2023 | β |
| Global comparative transcriptomes uncover novel and population-specific gene expression in esophageal squamous cell carcinoma. | Alotaibi A et al. | β | 2023 | β |
| Identifying and analyzing the key genes shared by papillary thyroid carcinoma and Hashimoto's thyroiditis using bioinformatics methods. | Liu TT et al. | β | 2023 | β |
| Mediation analysis unveils a carcinogenic effect of ADH1B rs1229984 through mechanisms other than change in drinking intensity: oesophageal cancer case-control study. | Sugimoto Y et al. | β | 2023 | β |
| Risk for Esophageal Cancer Based on Lifestyle Factors-Smoking, Alcohol Consumption, and Body Mass Index: Insight from a South Korean Population Study in a Low-Incidence Area. | Kwon MJ et al. | β | 2023 | β |
| Saturated fatty acid intake, genetic risk and colorectal cancer incidence: A large-scale prospective cohort study. | Fan L et al. | β | 2023 | β |
| The analysis of periodontal diseases and squamous cell esophageal cancer: A retrospective study. | Haque T et al. | β | 2023 | β |
| The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress? | Jardim SR et al. | β | 2023 | β |
| Alcohol Consumption, <i>ALDH2</i> Polymorphism as Risk Factors for Upper Aerodigestive Tract Cancer Progression and Prognosis. | Chen CH et al. | β | 2022 | β |
| Aldehyde Dehydrogenase 2 as a Therapeutic Target in Oxidative Stress-Related Diseases: Post-Translational Modifications Deserve More Attention. | Gao J et al. | β | 2022 | β |
| Can gene therapy be used to prevent cancer? Gene therapy for aldehyde dehydrogenase 2 deficiency. | Montel RA et al. | β | 2022 | β |
| Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma. | Toda S et al. | β | 2022 | β |
| Effect of Marital Status on Upper Digestive Tract Tumor Survival: Married Male Patients Exhibited a Better Prognosis. | Qing M et al. | β | 2022 | β |
| Esophageal Cancer Genomics in Africa: Recommendations for Future Research. | Simba H et al. | β | 2022 | β |
| Familial Esophageal Cancer in Taihang Mountain, China: An Era of Personalized Medicine Based on Family and Population Perspective. | Zheng Y et al. | β | 2022 | β |
| Favourable Lifestyle Protects Cognitive Function in Older Adults With High Genetic Risk of Obesity: A Prospective Cohort Study. | Liu H et al. | β | 2022 | β |
| Genetic Variations of ALDH (rs671) Are Associated With the Persistence of HBV Infection Among the Chinese Han Population. | Shang D et al. | β | 2022 | β |
| Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans. | Yang W et al. | β | 2022 | β |
| Is young-onset esophageal adenocarcinoma increasing in Japan? An analysis of population-based cancer registries. | Saito E et al. | β | 2022 | β |
| Potentially functional genetic variants of the notch signaling pathway genes predict survival of Chinese patients with esophageal squamous cell carcinoma. | Wu Y et al. | β | 2022 | β |
| Upper Gastrointestinal Cancer and Liver Cirrhosis. | Jeng KS et al. | β | 2022 | β |
| A genome-wide association study on confection consumption in a Japanese population: the Japan Multi-Institutional Collaborative Cohort Study. | Suzuki T et al. | β | 2021 | β |
| Alcohol Consumption and Cigarette Smoking among Young Adults: An Instrumental Variable Analysis Using Alcohol Flushing. | Jee Y et al. | β | 2021 | β |
| Association between ALDH2 polymorphism and esophageal cancer risk in South Koreans: a case-control study. | Choi CK et al. | β | 2021 | β |
| Comparative investigation of early-onset gastric cancer. | Ma Z et al. | β | 2021 | β |
| Comprehensive analysis reveals distinct mutational signature and its mechanistic insights of alcohol consumption in human cancers. | Wei R et al. | β | 2021 | β |
| Comprehensive Study of Germline Mutations and Double-Hit Events in Esophageal Squamous Cell Cancer. | Zeng B et al. | β | 2021 | β |
| Cross-talk between next generation sequencing methodologies to identify genomic signatures of esophageal cancer. | Verma R et al. | β | 2021 | β |
| <i>ALDH2</i> p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old. | Sasaki T et al. | β | 2021 | β |
| <i>RAD50</i> Loss of Function Variants in the Zinc Hook Domain Associated with Higher Risk of Familial Esophageal Squamous Cell Carcinoma. | Ko JMY et al. | β | 2021 | β |
| Lifestyles, genetics, and future perspectives on gastric cancer in east Asian populations. | Katoh H et al. | β | 2021 | β |
| Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence. | Moody S et al. | β | 2021 | β |
| Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer. | Wang M et al. | β | 2021 | β |
| Oncogenic SNORD12B activates the AKT-mTOR-4EBP1 signaling in esophageal squamous cell carcinoma via nucleus partitioning of PP-1Ξ±. | Tian B et al. | β | 2021 | β |
| Risk factors for esophageal iodine-unstained lesions and changing trends among Japanese alcohol-dependent men (2003-2018). | Yokoyama A et al. | β | 2021 | β |
| Risk of gout among Taiwanese adults with ALDH-2 rs671 polymorphism according to BMI and alcohol intake. | Liu YR et al. | β | 2021 | β |
| The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment. | Zhang H et al. | β | 2021 | β |
| Tumor infiltrating lymphocyte signature is associated with single nucleotide polymorphisms and predicts survival in esophageal squamous cell carcinoma patients. | Suo C et al. | β | 2021 | β |
| Understanding the cellular origin and progression of esophageal cancer using esophageal organoids. | Sachdeva UM et al. | β | 2021 | β |
| Alcohol Use and Gastrointestinal Cancer Risk. | ScherΓΌbl H | β | 2020 | β |
| A multinational review: Oesophageal cancer in low to middle-income countries. | Hull R et al. | β | 2020 | β |
| BRCA2 loss-of-function germline mutations are associated with esophageal squamous cell carcinoma risk in Chinese. | Ko JM et al. | β | 2020 | β |
| Genetic variants in GHR and PLCE1 genes are associated with susceptibility to esophageal cancer. | Wang R et al. | β | 2020 | β |
| Identification of key genes and pathways associated with esophageal squamous cell carcinoma development based on weighted gene correlation network analysis. | Shao M et al. | β | 2020 | β |
| Identification of Leukocyte telomere length-related genetic variants contributing to predisposition of Esophageal Squamous Cell Carcinoma. | Li Z et al. | β | 2020 | β |
| Impacts of interactions between ADH1B and ALDH2 genotypes on alcohol flushing, alcohol reeking on the day after drinking, and age distribution in Japanese alcohol-dependent men. | Yokoyama A et al. | β | 2020 | β |
| Inter- and intratumor DNA methylation heterogeneity associated with lymph node metastasis and prognosis of esophageal squamous cell carcinoma. | Teng H et al. | β | 2020 | β |
| Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism. | Inoue M et al. | β | 2020 | β |
| Risk of second primary malignancies after definitive treatment for esophageal cancer: A competing risk analysis. | Mitani S et al. | β | 2020 | β |
| The Alcohol Use Disorders Identification Test and the risk of metachronous cancer after endoscopic resection of esophageal cancer. | Yokoyama A et al. | β | 2020 | β |
| The ChinaMAP analytics of deep whole genome sequences in 10,588 individuals. | Cao Y et al. | β | 2020 | β |
| The disparities in gastrointestinal cancer incidence among Chinese populations in Shanghai compared to Chinese immigrants and indigenous non-Hispanic white populations in Los Angeles, USA. | Liu Z et al. | β | 2020 | β |
| TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines. | Jiang YY et al. | β | 2020 | β |
| Unraveling cancer lineage drivers in squamous cell carcinomas. | Guan Y et al. | β | 2020 | β |
| A decade in psychiatric GWAS research. | Horwitz T et al. | β | 2019 | β |
| Alcohol consumption and vascular disease: other points to consider. | Chen CH et al. | β | 2019 | β |
| Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk. | Suo C et al. | β | 2019 | β |
| ALDH2 Polymorphism and Ethanol Consumption: A Genetic-Environmental Interaction in Carcinogenesis. | Yang M et al. | β | 2019 | β |
| A Model Shows Utility in Predicting Postoperative Recurrence and Distant Metastasis in Curatively Resected Esophageal Squamous Cell Cancer. | Wang W et al. | β | 2019 | β |
| Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population. | Chen WC et al. | β | 2019 | β |
| Association of <i>ADH1B</i> Arg47His polymorphism with the risk of cancer: a meta-analysis. | Tan B et al. | β | 2019 | β |
| Clinical and translational advances in esophageal squamous cell carcinoma. | Reichenbach ZW et al. | β | 2019 | β |
| Construction of a risk model for the development of metachronous squamous cell carcinoma after endoscopic resection of esopahageal squamous cell carcinoma. | Urabe Y et al. | β | 2019 | β |
| Effect of ALDH2 polymorphism on cancer risk in Asians: A meta-analysis. | Zuo W et al. | β | 2019 | β |
| Endoscopic screening using esophageal iodine staining and genotypes of ADH1B and ALDH2 in Japanese alcohol-dependent women. | Yokoyama A et al. | β | 2019 | β |
| Gene Therapy Correction of Aldehyde Dehydrogenase 2 Deficiency. | Matsumura Y et al. | β | 2019 | β |
| GWAS of habitual coffee consumption reveals a sex difference in the genetic effect of the 12q24 locus in the Japanese population. | Jia H et al. | β | 2019 | β |
| Maintenance of Intestinal Epithelial Homeostasis by Zinc Transporters. | Ohashi W et al. | β | 2019 | β |
| SOX2 antagonizes WWC1 to drive YAP1 activation in esophageal squamous cell carcinoma. | Chai Y et al. | β | 2019 | β |
| The Bidirectional Effect of Defective ALDH2 Polymorphism and Disease Prevention. | Matsumoto A | β | 2019 | β |
| Aldehyde-Induced DNA and Protein Adducts as Biomarker Tools for Alcohol Use Disorder. | Heymann HM et al. | β | 2018 | β |
| Deep whole-genome sequencing reveals recent selection signatures linked to evolution and disease risk of Japanese. | Okada Y et al. | β | 2018 | β |
| Detection of Second Primary Malignancies of the Esophagus and Hypophraynx in Oral Squamous Cell Carcinoma Patients. | Matsui T et al. | β | 2018 | β |
| Gastric cancer may share genetic predisposition with esophageal squamous cell carcinoma in Chinese populations. | Yao L et al. | β | 2018 | β |
| Genome-Wide Association Studies of Cancer in Diverse Populations. | Park SL et al. | β | 2018 | β |
| Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2: temperance reduces the risk. | Abiko S et al. | β | 2018 | β |
| The global spectrum of protein-coding pharmacogenomic diversity. | Wright GEB et al. | β | 2018 | β |
| Type of second primary malignancy after achieving complete response by definitive chemoradiation therapy in patients with esophageal squamous cell carcinoma. | Yamaguchi T et al. | β | 2018 | β |
| Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer. | Yokoyama A et al. | β | 2017 | β |
| Alcohol metabolism and oesophageal cancer: a systematic review of the evidence. | Matejcic M et al. | β | 2017 | β |
| Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice. | Hou G et al. | β | 2017 | β |
| Association between ALDH2 Glu487Lys polymorphism and the risk of esophageal cancer. | Liu K et al. | β | 2017 | β |
| Association of genotypes of rs671 within<i>ALDH2</i> with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas. | Zhang LQ et al. | β | 2017 | β |
| Candidate susceptibility variants for esophageal squamous cell carcinoma. | Donner I et al. | β | 2017 | β |
| Comparative genomic analysis of esophageal squamous cell carcinoma between Asian and Caucasian patient populations. | Deng J et al. | β | 2017 | β |
| CRISPR/Cas9 Engineering of Adult Mouse Liver DemonstratesΒ That the Dnajb1-Prkaca Gene Fusion Is SufficientΒ to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma. | Engelholm LH et al. | β | 2017 | β |
| Excessive alcohol consumption increases mortality in later life: a genetic analysis of the health in men cohort study. | Almeida OP et al. | β | 2017 | β |
| Factors associated with the high prevalence of oesophageal cancer in Western Kenya: a review. | Kigen G et al. | β | 2017 | β |
| GWAS follow-up study of esophageal squamous cell carcinoma identifies potential genetic loci associated with family history of upper gastrointestinal cancer. | Song X et al. | β | 2017 | β |
| Integrated genomic characterization of oesophageal carcinoma. | Cancer Genome Atlas Research Network et al. | β | 2017 | β |
| Integrative Pathway Analysis of Genes and Metabolites Reveals Metabolism Abnormal Subpathway Regions and Modules in Esophageal Squamous Cell Carcinoma. | Li C et al. | β | 2017 | β |
| Lessons Learned From Past Gene-Environment Interaction Successes. | Ritz BR et al. | β | 2017 | β |
| Leukocyte telomere length-related genetic variants in ACYP2 contribute to the risk of esophageal carcinoma in Chinese Han population. | Fang Q et al. | β | 2017 | β |
| Oesophageal cancer. | Smyth EC et al. | β | 2017 | β |
| Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe. | Lu M et al. | β | 2017 | β |
| Racial Disparity in Gastrointestinal Cancer Risk. | Ashktorab H et al. | β | 2017 | β |
| Recovery from anemia and leukocytopenia after abstinence in Japanese alcoholic men and their genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2. | Yokoyama A et al. | β | 2017 | β |
| Soft palatal melanosis, a simple predictor for neoplasia in the upper aerodigestive tract in Japanese alcoholic men. | Hirata K et al. | β | 2017 | β |
| Supporting precision medicine by data mining across multi-disciplines: an integrative approach for generating comprehensive linkages between single nucleotide variants (SNVs) and drug-binding sites. | Roy Choudhury A et al. | β | 2017 | β |
| The allele frequency of ALDH2*Glu504Lys and ADH1B*Arg47His for the Ryukyu islanders and their history of expansion among East Asians. | Koganebuchi K et al. | β | 2017 | β |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
| Whole-exome sequencing reveals critical genes underlying metastasis in oesophageal squamous cell carcinoma. | Dai W et al. | β | 2017 | β |
| ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma. | Kagemoto K et al. | β | 2016 | β |
| Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: gene-environment interaction. | Masaoka H et al. | β | 2016 | β |
| Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a meta-analysis. | Mao N et al. | β | 2016 | β |
| Blood Leukocyte Counts and Genetic Polymorphisms of Alcohol Dehydrogenase-1B and Aldehyde Dehydrogenase-2 in Japanese Alcoholic Men. | Yokoyama A et al. | β | 2016 | β |
| Convergent evidence from systematic analysis of GWAS revealed genetic basis of esophageal cancer. | Gao XX et al. | β | 2016 | β |
| Developing precision medicine for people of East Asian descent. | McAllister SL et al. | β | 2016 | β |
| Etiology and Prevention of Esophageal Cancer. | Yang CS et al. | β | 2016 | β |
| Gene-gene interactions in gastrointestinal cancer susceptibility. | Kim J et al. | β | 2016 | β |
| Genomic Landscape of Esophageal Squamous Cell Carcinoma inΒ a Japanese Population. | Sawada G et al. | β | 2016 | β |
| Plasma matrix metalloproteinase 1 improves the detection and survival prediction of esophageal squamous cell carcinoma. | Chen YK et al. | β | 2016 | β |
| Prognostic significance of circulating tumor cells in esophageal carcinoma: a meta-analysis. | Qiao GL et al. | β | 2016 | β |
| Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men. | Hashimoto M et al. | β | 2016 | β |
| Review of the Gene-Environment Interaction Literature in Cancer: What Do We Know? | Simonds NI et al. | β | 2016 | β |
| Roles of defective ALDH2 polymorphism on liver protection and cancer development. | Matsumoto A et al. | β | 2016 | β |
| Salvage endoscopic resection as a treatment for locoregional failure or recurrence following chemoradiotherapy or radiotherapy for esophageal cancer. | Nakamura R et al. | β | 2016 | β |
| The Sp1-mediaded allelic regulation of MMP13 expression by an ESCC susceptibility SNP rs2252070. | Shi M et al. | β | 2016 | β |
| Alcohol dehydrogenase-1B Arg47His polymorphism is associated with head and neck cancer risk in Asian: a meta-analysis. | Zhang Y et al. | β | 2015 | β |
| A miR-29c binding site genetic variant in the 3'-untranslated region of LAMTOR3 gene is associated with gastric cancer risk. | Song P et al. | β | 2015 | β |
| A personalized medicine approach for Asian Americans with the aldehyde dehydrogenase 2*2 variant. | Gross ER et al. | β | 2015 | β |
| A perspective on chemoprevention by resveratrol in head and neck squamous cell carcinoma. | Shrotriya S et al. | β | 2015 | β |
| Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. | Cai Q et al. | β | 2015 | β |
| Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. | Manzardo AM et al. | β | 2015 | β |
| Clinical significance of ALDH2 rs671 polymorphism in esophageal cancer: evidence from 31 case-control studies. | Zhao T et al. | β | 2015 | β |
| Combined effects of current-smoking and the aldehyde dehydrogenase 2*2 allele on the risk of myocardial infarction in Japanese patients. | Morita K et al. | β | 2015 | β |
| Common genetic variants in epigenetic machinery genes and risk of upper gastrointestinal cancers. | Sung H et al. | β | 2015 | β |
| Comparison of clinicopathologic features and survival between eastern and western population with esophageal squamous cell carcinoma. | Zhang J et al. | β | 2015 | β |
| Esophageal squamous cell carcinoma (ESCC): advance in genomics and molecular genetics. | Chen J et al. | β | 2015 | β |
| Estimates of alcohol-related oesophageal cancer burden in Japan: systematic review and meta-analyses. | Roerecke M et al. | β | 2015 | β |
| Functional BCL-2 regulatory genetic variants contribute to susceptibility of esophageal squamous cell carcinoma. | Pan W et al. | β | 2015 | β |
| Gene-environment interactions in esophageal cancer. | Matejcic M et al. | β | 2015 | β |
| Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking. | Eriksson CJ | β | 2015 | β |
| Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2, alcohol flushing, mean corpuscular volume, and aerodigestive tract neoplasia in Japanese drinkers. | Yokoyama A et al. | β | 2015 | β |
| Genetic variants at 6p21, 10q23, 16q21 and 22q12 are associated with esophageal cancer risk in a Chinese Han population. | Jia X et al. | β | 2015 | β |
| Genetic variation in C12orf51 is associated with prognosis of intestinal-type gastric cancer in a Chinese population. | Zhang G et al. | β | 2015 | β |
| LincRNA-uc002yug.2 involves in alternative splicing of RUNX1 and serves as a predictor for esophageal cancer and prognosis. | Wu H et al. | β | 2015 | β |
| Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium. | Amanuma Y et al. | β | 2015 | β |
| Recent Advances From Basic and Clinical Studies of Esophageal Squamous Cell Carcinoma. | Ohashi S et al. | β | 2015 | β |
| ABCC4 copy number variation is associated with susceptibility to esophageal squamous cell carcinoma. | Sun Y et al. | β | 2014 | β |
| A functional TNFAIP2 3'-UTR rs8126 genetic polymorphism contributes to risk of esophageal squamous cell carcinoma. | Zhang J et al. | β | 2014 | β |
| Association of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study. | Park SL et al. | β | 2014 | β |
| Comparative genomic analysis of esophageal cancers. | Caygill CP et al. | β | 2014 | β |
| Epidemiological studies of esophageal cancer in the era of genome-wide association studies. | Wang AH et al. | β | 2014 | β |
| Ethanol reduces lifespan, body weight, and serum alanine aminotransferase level of aldehyde dehydrogenase 2 knockout mouse. | Matsumoto A et al. | β | 2014 | β |
| Gene-environment interactions on the risk of esophageal cancer among Asian populations with the G48A polymorphism in the alcohol dehydrogenase-2 gene: a meta-analysis. | Zhang L et al. | β | 2014 | β |
| Genetic variant of single-nucleotide polymorphism is associated with risk of esophageal squamous cell carcinoma. | Ye B et al. | β | 2014 | β |
| Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion. | Yukawa Y et al. | β | 2014 | β |
| Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. | Wen W et al. | β | 2014 | β |
| PLCE1 mRNA and protein expression and survival of patients with esophageal squamous cell carcinoma and gastric adenocarcinoma. | Li WQ et al. | β | 2014 | β |
| Potentially functional polymorphisms in the ERCC2 gene and risk of esophageal squamous cell carcinoma in Chinese populations. | Zhu ML et al. | β | 2014 | β |
| Replication study of ESCC susceptibility genetic polymorphisms locating in the ADH1B-ADH1C-ADH7 cluster identified by GWAS. | Wang J et al. | β | 2014 | β |
| Single nucleotide polymorphism at alcohol dehydrogenase-1B is associated with risk of esophageal squamous cell carcinoma. | Ye B et al. | β | 2014 | β |
| Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis. | Chung CS et al. | β | 2014 | β |
| The ALDH7A1 genetic polymorphisms contribute to development of esophageal squamous cell carcinoma. | Wang H et al. | β | 2014 | β |
| A genetic polymorphism in lincRNA-uc003opf.1 is associated with susceptibility to esophageal squamous cell carcinoma in Chinese populations. | Wu H et al. | β | 2013 | β |
| A health-risk appraisal model and endoscopic mass screening for esophageal cancer in Japanese men. | Yokoyama A et al. | β | 2013 | β |
| Alcohol and acetaldehyde in African fermented milk mursik--a possible etiologic factor for high incidence of esophageal cancer in western Kenya. | Nieminen MT et al. | β | 2013 | β |
| ALDH2 genotype has no effect on salivary acetaldehyde without the presence of ethanol in the systemic circulation. | Helminen A et al. | β | 2013 | β |
| Association of a genetic variation in a miR-191 binding site in MDM4 with risk of esophageal squamous cell carcinoma. | Zhou L et al. | β | 2013 | β |
| Association of CHRNA5-A3-B4 variation with esophageal squamous cell carcinoma risk and smoking behaviors in a Chinese population. | Wang Y et al. | β | 2013 | β |
| Epidemiology of esophageal cancer in Japan and China. | Lin Y et al. | β | 2013 | β |
| Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population. | Gao Y et al. | β | 2013 | β |
| Genetic variants at 4q23 and 12q24 are associated with head and neck cancer risk in China. | Yuan H et al. | β | 2013 | β |
| Genetic variants at 5p15 are associated with risk and early onset of gastric cancer in Chinese populations. | Du J et al. | β | 2013 | β |
| Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population. | Li WQ et al. | β | 2013 | β |
| Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a Chinese population. | Li WQ et al. | β | 2013 | β |
| Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma. | Wu C et al. | β | 2013 | β |
| Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. | Low SK et al. | β | 2013 | β |
| Genomic alterations in advanced esophageal cancer may lead to subtype-specific therapies. | Forde PM et al. | β | 2013 | β |
| Polymorphisms in alcohol-metabolizing enzymes and esophageal carcinoma susceptibility: a Dutch Caucasian case-control study. | Dura P et al. | β | 2013 | β |
| Polymorphisms in the gene regions of the adaptor complex LAMTOR2/LAMTOR3 and their association with breast cancer risk. | De Araujo ME et al. | β | 2013 | β |
| Risk prediction of esophageal squamous-cell carcinoma with common genetic variants and lifestyle factors in Chinese population. | Chang J et al. | β | 2013 | β |
| Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: a population-based case-control study in China. | Wu M et al. | β | 2013 | β |
| Skewed X-chromosome inactivation in patients with esophageal carcinoma. | Li G et al. | β | 2013 | β |
| The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer. | Matsuo K et al. | β | 2013 | β |
| The case-only test for gene-environment interaction is not uniformly powerful: an empirical example. | Wu C et al. | β | 2013 | β |
| The genetics of alcohol dependence. | Rietschel M et al. | β | 2013 | β |
| Trends in gastrectomy and ADH1B and ALDH2 genotypes in Japanese alcoholic men and their gene-gastrectomy, gene-gene and gene-age interactions for risk of alcoholism. | Yokoyama A et al. | β | 2013 | β |
| Alcohol dehydrogenase-1B Arg47His polymorphism and upper aerodigestive tract cancer risk: a meta-analysis including 24,252 subjects. | Guo H et al. | β | 2012 | β |
| A variant allele of ADH1B and ALDH2, is associated with the risk of esophageal cancer. | Gu H et al. | β | 2012 | β |
| Cancer stem cell marker ALDH1 expression is associated with lymph node metastasis and poor survival in esophageal squamous cell carcinoma: a study from high incidence area of northern China. | Wang Y et al. | β | 2012 | β |
| Development of squamous neoplasia in esophageal iodine-unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men. | Yokoyama A et al. | β | 2012 | β |
| Distinct genetic association at the PLCE1 locus with oesophageal squamous cell carcinoma in the South African population. | Bye H et al. | β | 2012 | β |
| Epidemiologic differences in esophageal cancer between Asian and Western populations. | Zhang HZ et al. | β | 2012 | β |
| Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human large bowel: association of the functional polymorphisms of ADH and ALDH genes with hemorrhoids and colorectal cancer. | Chiang CP et al. | β | 2012 | β |
| Expression pattern, ethanol-metabolizing activities, and cellular localization of alcohol and aldehyde dehydrogenases in human small intestine. | Chiang CP et al. | β | 2012 | β |
| Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study. | Tomoda T et al. | β | 2012 | β |
| Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. | Wu C et al. | β | 2012 | β |
| Genome-wide association analysis identifies three new breast cancer susceptibility loci. | Ghoussaini M et al. | β | 2012 | β |
| Heterozygote genotypes at rs2222823 and rs2811712 SNP loci are associated with cerebral small vessel disease in Han Chinese population. | Li W et al. | β | 2012 | β |
| Putatively functional PLCE1 variants and susceptibility to esophageal squamous cell carcinoma (ESCC): a case-control study in eastern Chinese populations. | Hu H et al. | β | 2012 | β |
| Recommendations and proposed guidelines for assessing the cumulative evidence on joint effects of genes and environments on cancer occurrence in humans. | Boffetta P et al. | β | 2012 | β |
| Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma. | Kumar V et al. | β | 2012 | β |
| Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. | Li D et al. | β | 2012 | β |
| The genetics of substance dependence. | Wang JC et al. | β | 2012 | β |
| Acetaldehyde and gastric cancer. | Salaspuro M | β | 2011 | β |
| A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains. | Avery CL et al. | β | 2011 | β |
| A polymorphism in the chromosome 9p21 ANRIL locus is associated to Philadelphia positive acute lymphoblastic leukemia. | Iacobucci I et al. | β | 2011 | β |
| Associations of high-grade glioma with glioma risk alleles and histories of allergy and smoking. | Lachance DH et al. | β | 2011 | β |
| Cancer stem cell radioresistance and enrichment: where frontline radiation therapy may fail in lung and esophageal cancers. | Nguyen GH et al. | β | 2011 | β |
| Common variant in 6q26-q27 is associated with distal colon cancer in an Asian population. | Cui R et al. | β | 2011 | β |
| Genetic testing for aldehyde dehydrogenase 2 deficiency in young adults. | Hendershot CS | β | 2011 | β |
| Genome-wide association studies for detecting cancer susceptibility. | Hosking FJ et al. | β | 2011 | β |
| Genome-wide association studies of alcohol intake--a promising cocktail? | Agrawal A et al. | β | 2011 | β |
| Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. | Wu C et al. | β | 2011 | β |
| Inverse association between toothbrushing and upper aerodigestive tract cancer risk in a Japanese population. | Sato F et al. | β | 2011 | β |
| Polymorphisms affecting micro-RNA regulation and associated with the risk of dietary-related cancers: a review from the literature and new evidence for a functional role of rs17281995 (CD86) and rs1051690 (INSR), previously associated with colorectal cancer. | Landi D et al. | β | 2011 | β |
| Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectin. | Park JH et al. | β | 2011 | β |
| Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa. | Bye H et al. | β | 2011 | β |
| Revisit of field cancerization in squamous cell carcinoma of upper aerodigestive tract: better risk assessment with epigenetic markers. | Lee YC et al. | β | 2011 | β |
| A compendium of genome-wide associations for cancer: critical synopsis and reappraisal. | Ioannidis JP et al. | β | 2010 | β |
| ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis. | Zhang G et al. | β | 2010 | β |
| A genetic perspective on coeliac disease. | Trynka G et al. | β | 2010 | β |
| Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians. | Yokoyama A et al. | β | 2010 | β |
| A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. | Abnet CC et al. | β | 2010 | β |
| Deficient aldehyde dehydrogenase 2 is associated with increased risk for esophageal squamous cell carcinoma in the presence of gastric hypochlorhydria. | Oikawa T et al. | β | 2010 | β |
| Genetic predisposition to gastro-oesophageal cancer. | Lao-Sirieix P et al. | β | 2010 | β |
| Genetic variants in MicroRNA biosynthesis pathways and binding sites modify ovarian cancer risk, survival, and treatment response. | Liang D et al. | β | 2010 | β |
| Genome-wide association studies of cancer. | Stadler ZK et al. | β | 2010 | β |
| Genome-wide association studies of cancer predisposition. | Stadler ZK et al. | β | 2010 | β |
| Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at PLCE1 and C20orf54. | Wang LD et al. | β | 2010 | β |
| Late presentation of esophageal cancer: observations in a multiracial South-East Asian population. | Abdullah M et al. | β | 2010 | β |
| Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China. | Zhang GH et al. | β | 2010 | β |
| Search for cancer risk factors with microarray-based genome-wide association studies. | Zhang L et al. | β | 2010 | β |
| The changing face of esophageal cancer. | Melhado RE et al. | β | 2010 | β |
| Genome-wide association study in esophageal squamous cell carcinoma. | Bass AJ et al. | β | 2009 | β |