A family-based analysis of whether the functional promoter alleles of the serotonin transporter gene HTT affect the risk for alcohol dependence.
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- Authors
- Edenberg, H J; Reynolds, J; Koller, D L; Begleiter, H; Bucholz, K K; Conneally, P M; Crowe, R; Goate, A; Hesselbrock, V; Li, T K; Nurnberger, J I; Porjesz, B; Reich, T; Rice, J P; Schuckit, M; Tischfield, J A; Foroud, T
- Year
- 1998
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 9726278
A population association between a regulatory variation in the promoter of the serotonin transporter gene (HTT) and severe alcohol dependence was recently reported. We analyzed this potential association in a large number of systematically ascertained families in the United States; these families had at least three first-degree relatives who were alcohol-dependent. Analyses focused on individuals defined as alcohol-dependent by criteria from ICD-10 and on subsets of these individuals reporting withdrawal-related symptoms. Application of the transmission disequilibrium test did not provide support for either linkage or association between this functional polymorphism and alcohol dependence; there was no significant bias in the transmission of either allele to the alcohol-dependent offspring. We also report that African Americans differ from Caucasians in allele frequencies for this polymorphism.
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