Technological issues and experimental design of gene association studies.
- Authors
- Distefano, Johanna K; Taverna, Darin M
- Year
- 2011
- Journal
- Methods in molecular biology (Clifton, N.J.)
- PMID
- 21204023
- DOI
- 10.1007/978-1-61737-954-3_1
Genome-wide association studies (GWAS), in which thousands of single-nucleotide polymorphisms (SNPs) spanning the genome are genotyped in individuals who are phenotypically well characterized, -currently represent the most popular strategy for identifying gene regions associated with common -diseases and related quantitative traits. Improvements in technology and throughput capability, development of powerful statistical tools, and more widespread acceptance of pooling-based genotyping approaches have led to greater utilization of GWAS in human genetics research. However, important considerations for optimal experimental design, including selection of the most appropriate genotyping platform, can enhance the utility of the approach even further. This chapter reviews experimental and technological issues that may affect the success of GWAS findings and proposes strategies for developing the most comprehensive, logical, and cost-effective approaches for genotyping given the population of interest.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| An Overview of Genome-Wide Association Studies. | Chang M et al. | — | 2018 | → |
| Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells? | Prytkova I et al. | — | 2018 | → |
| Big data challenges in bone research: genome-wide association studies and next-generation sequencing. | Alonso N et al. | — | 2015 | → |
| The Human Genome Project, and recent advances in personalized genomics. | Wilson BJ et al. | — | 2015 | → |
| Bioinformatics challenges in genome-wide association studies (GWAS). | De R et al. | — | 2014 | → |
| Introduction to genetics and genomics in asthma: genetics of asthma. | Mathias RA | — | 2014 | → |
| Type I diabetes mellitus: genetic factors and presumptive enteroviral etiology or protection. | Precechtelova J et al. | — | 2014 | → |
| Chapter 11: Genome-wide association studies. | Bush WS et al. | — | 2012 | → |
| Molecular genomic research designs. | Baumgartel K et al. | — | 2011 | → |
| Personal genome testing: test characteristics to clarify the discourse on ethical, legal and societal issues. | Bunnik EM et al. | — | 2011 | → |