Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance.
paper
Cited
Public
Unavailable
- Authors
- Zong, Haihong; Armoni, Michal; Harel, Chava; Karnieli, Eddy; Pessin, Jeffrey E
- Year
- 2012
- Journal
- American journal of physiology. Endocrinology and metabolism
- PMID
- 22185839
- DOI
- 10.1152/ajpendo.00258.2011
- PMCID
- PMC3311288
Conventional (whole body) CYP2E1 knockout mice displayed protection against high-fat diet-induced weight gain, obesity, and hyperlipidemia with increased energy expenditure despite normal food intake and spontaneous locomotor activity. In addition, the CYP2E1 knockout mice displayed a marked improvement in glucose tolerance on both normal chow and high-fat diets. Euglycemic-hyperinsulinemic clamps demonstrated a marked protection against high-fat diet-induced insulin resistance in CYP2E1 knockout mice, with enhanced adipose tissue glucose uptake and insulin suppression of hepatic glucose output. In parallel, adipose tissue was protected against high-fat diet-induced proinflammatory cytokine production. Taken together, these data demonstrate that the CYP2E1 deletion protects mice against high-fat diet-induced insulin resistance with improved glucose homeostasis in vivo.
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