Purmorphamine activates the Hedgehog pathway by targeting Smoothened.
paper
Cited
Public
Unavailable
- Authors
- Sinha, Surajit; Chen, James K
- Year
- 2006
- Journal
- Nature chemical biology
- PMID
- 16408088
- DOI
- 10.1038/nchembio753
Hedgehog (Hh) signaling is an important regulator of embryonic patterning, tissue regeneration, stem cell renewal and cancer growth. A purine derivative named purmorphamine was previously found to activate the Hh pathway and affect osteoblast differentiation through an unknown mechanism. We demonstrate here that purmorphamine directly targets Smoothened, a critical component of the Hh signaling pathway.
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