Genome screen for platelet monoamine oxidase (MAO) activity.
- Authors
- Saccone, N L; Rice, J P; Rochberg, N; Goate, A; Reich, T; Shears, S; Wu, W; Nurnberger, J I; Foroud, T; Edenberg, H J; Li, T K
- Year
- 1999
- Journal
- American journal of medical genetics
- PMID
- 10490709
- DOI
- 10.1002/(sici)1096-8628(19991015)88:5<517::aid-ajmg15>3.0.co;2-b
To identify loci involved in the control of platelet monoamine oxidase B (MAO-B) activity, a genomewide linkage screen was performed using 291 markers in 148 nuclear families containing a total of 1,008 nonindependent sib-pairs. Participants were genotyped and their platelet MAO-B activity levels were measured as part of the Collaborative Study on the Genetics of Alcoholism (COGA). Sib-pair analysis using Haseman-Elston regression was carried out with two programs. Two-point analysis on all pairs with SIBPAL indicated three markers with p-values below 0.01: D6S1018 (p = 0.0004), D2S1328 (p = 0.008), and D2S408 (p = 0.003). MAPMAKER/SIBS multipoint analyses using independent pairs(N = 409) gave maximal lod scores of 2. 0 on chromosome 6 and 1.1 and 1.4 for the two regions on chromosome 2. These results are consistent with linkage, but do not provide definitive evidence. We are currently creating a denser map in these regions and have begun genotyping a second sample in COGA.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
No papers in this knowledge base cite this source.
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Astrocytes and therapeutics for Parkinson's disease. | Rappold PM et al. | — | 2010 | → |
| Contribution of monoamine oxidase (MAO) inhibition to tobacco and alcohol addiction. | van Amsterdam J et al. | — | 2006 | → |
| The genetics of alcoholism: identifying specific genes through family studies. | Edenberg HJ et al. | — | 2006 | → |
| Linkage for platelet monoamine oxidase (MAO) activity: results from a replication sample. | Saccone NL et al. | — | 2002 | → |
| Relationships between effects of smoking, gender, and alcohol dependence on platelet monoamine oxidase-B: activity, affinity labeling, and protein measurements. | Snell LD et al. | — | 2002 | → |
| Definition of the phenotype. | Rice JP et al. | — | 2001 | → |
| Genetic covariation of neuroticism with monoamine oxidase activity and smoking. | Kirk KM et al. | — | 2001 | → |
| A genome screen of maximum number of drinks as an alcoholism phenotype. | Saccone NL et al. | — | 2000 | → |
| Segregation analysis of drinking problem in elderly men and their first-degree relatives from the Western Collaborative Group Study. | Cheng LS et al. | — | 2000 | → |