Obsessive-compulsive disorder in Tourette's syndrome.
- Authors
- Como, Peter G; LaMarsh, Jennifer; O'Brien, Katherine A
- Year
- 2005
- Journal
- Advances in neurology
- PMID
- 16383224
A substantial body of scientific evidence suggests that obsessive-compulsive behavior occurs in a large percentage of patients with TS. Reliable estimates suggest that nearly 50% of patients with TS have some degree of obsessive-compulsive features. Most patients with TS have only mild OCB and thus would not meet the DSM-IV diagnostic criteria for OCD. Therefore, OCB is perhaps a more appropriate characterization of this behavioral phenomenon that occurs in TS. OCB in TS appears similar to the spectrum of the tic disorder in terms of its onset, severity, and course. As with tics, OCB is typically mild and not always substantially disabling. Although clinical features between TS + OCB and primary OCD overlap considerably, patients with TS + OCB appear to experience different types of obsessive thoughts and compulsive rituals. Compelling genetic evidence suggests that OCB may be an alternative expression of the TS phenotype, which may selectively affect female gene carriers. Identifying the TS gene in the future will substantially broaden our knowledge of this intriguing neurobehavioral disorder. Finally, neurobiologic evidence points to similar anatomic and chemical substrates in the pathogenesis of TS and OCD, suggesting that these two disorders share a common pathophysiology. The clinical evaluation of patients with TS and their families should always include an assessment for OCB. Self-rated inventories of OCD such as the LOI, LOI-CV, and MOCI are useful screening scales. A more structured interview using the Y-BOCS (CY-BOCS) is useful for determining the degree and severity of OCB in TS as well as the response to therapy. Clinicians should keep in mind that OCB may be the most disabling feature of TS and may require treatment. Pharmacologic agents, such as SSRIs, and traditional behavioral therapy are proven effective treatments for OCB, which can substantially reduce the full effect of TS on patients and their families.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. | 2015 | 25158072 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| On astrocyte-neuron interactions: Broad insights from the striatum. | Khakh BS | — | 2025 | → |
| A dimensional perspective on the genetics of obsessive-compulsive disorder. | Strom NI et al. | — | 2021 | → |
| Challenges in the Diagnosis and Assessment in Patients with Tourette Syndrome and Comorbid Obsessive-Compulsive Disorder. | Szejko N et al. | — | 2021 | → |
| Therapeutic Neurostimulation in Obsessive-Compulsive and Related Disorders: A Systematic Review. | Acevedo N et al. | — | 2021 | → |
| A Chinese Herbal Formulation, Xiao-Er-An-Shen Decoction, Attenuates Tourette Syndrome, Possibly by Reversing Abnormal Changes in Neurotransmitter Levels and Enhancing Antioxidant Status in Mouse Brain. | Chen J et al. | — | 2019 | → |
| Identification of Two Heritable Cross-Disorder Endophenotypes for Tourette Syndrome. | Darrow SM et al. | — | 2017 | → |
| Cross-Disorder Genetic Analysis of Tic Disorders, Obsessive-Compulsive, and Hoarding Symptoms. | Zilhão NR et al. | — | 2016 | → |
| Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD. | Yu D et al. | — | 2015 | → |
| Antiepileptic drugs and Tourette syndrome. | Cavanna AE et al. | — | 2013 | → |
| Relationship of obsessive-compulsive disorder to age-related comorbidity in children and adolescents with Tourette syndrome. | Wanderer S et al. | — | 2012 | → |
| Abnormal metabolic brain networks in Tourette syndrome. | Pourfar M et al. | — | 2011 | → |
| Basal ganglia MR relaxometry in obsessive-compulsive disorder: T2 depends upon age of symptom onset. | Correia S et al. | — | 2010 | → |
| Role of dopamine in the pathophysiology and treatment of obsessive-compulsive disorder. | Koo MS et al. | — | 2010 | → |
| Tourette syndrome. | Jimenez-Shahed J | — | 2009 | → |
| Catatonic signs in Gilles de la Tourette syndrome. | Cavanna AE et al. | — | 2008 | → |
| Donepezil use in children and adolescents with tics and attention-deficit/hyperactivity disorder: an 18-week, single-center, dose-escalating, prospective, open-label study. | Cubo E et al. | — | 2008 | → |
| Obsessive-compulsive disorder spectrum as a scientific "metaphor". | Pallanti S et al. | — | 2008 | → |
| Tourette's syndrome and role of tetrabenazine: review and personal experience. | Porta M et al. | — | 2008 | → |
| Validation of the presence of comorbidities in a Danish clinical cohort of children with Tourette syndrome. | Mol Debes NM et al. | — | 2008 | → |
| Malignant Tourette syndrome. | Cheung MY et al. | — | 2007 | → |