Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.
paper
Cited
Public
Unavailable
- Authors
- Tanaka, Fumiaki; Yamamoto, Ken; Suzuki, Sadao; Inoue, Hiroshi; Tsurumaru, Masahiko; Kajiyama, Yoshiaki; Kato, Hoichi; Igaki, Hiroyasu; Furuta, Koh; Fujita, Hiromasa; Tanaka, Toshiaki; Tanaka, Yoichi; Kawashima, Yoshiyuki; Natsugoe, Shoji; Setoyama, Tetsuro; Tokudome, Shinkan; Mimori, Koshi; Haraguchi, Naotsugu; Ishii, Hideshi; Mori, Masaki
- Year
- 2010
- Journal
- Gut
- PMID
- 20833657
- DOI
- 10.1136/gut.2009.205724
BACKGROUND: Oesophageal squamous cell carcinoma (OSCC) is considered a difficult cancer to cure. The detection of environmental and genetic factors is important for prevention on an individual basis. OBJECTIVE: To identify groups at high risk for OSCC by simultaneously analysing both genetic and environmental risk factors. Methods A multistage genome-wide association study of OSCC in Japanese individuals with a total of 1071 cases and 2762 controls was performed. RESULTS: Two associated single-nucleotide polymorphisms (SNPs), as well as smoking and alcohol consumption, were evaluated as genetic and environmental risk factors, respectively, and their interactions were also evaluated. Risk alleles of rs1229984 (ADH1B) and rs671 (ALDH2) were highly associated with OSCC (odds ratio (OR)=4.08, p=4.4Γ10(-40) and OR=4.13, p=8.4Γ10(-76), respectively). Also, smoking and alcohol consumption were identified as risk factors for OSCC development. By integrating both genetic and environmental risk factors, it was shown that the combination of rs1229984 and rs671 risk alleles with smoking and alcohol consumption was associated with OSCC. Compared with subjects with no more than one environmental or genetic risk factor, the OR reached 146.4 (95% CI 50.5 to 424.5) when both environmental and genetic risk factors were present. Without the genetic risks, alcohol consumption did not correlate with OSCC. In people with one or two genetic risk factors, the combination of alcohol consumption and smoking increased OSCC risk. CONCLUSIONS: Analysis of ADH1B and ALDH2 variants is valuable for secondary prevention of OSCC in high-risk patients who smoke and drink alcohol. In this study, SNP genotyping demonstrated that the ADH1B and/or ALDH2 risk alleles had an interaction with smoking and, especially, alcohol consumption. These findings, if replicated in other groups, could demonstrate new pathophysiological pathways for the development of OSCC.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| The genetics of substance dependence. | 2012 | 22703173 |
| Genetic vulnerability and susceptibility to substance dependence. | 2011 | 21338875 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects. | Hart SFM et al. | β | 2026 | β |
| Genetic risk stratification and preventive strategies for double primary HNSCC and ESCC: a single-center cohort study. | Naito S et al. | β | 2026 | β |
| A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects | Hart SF et al. | β | 2025 | β |
| Clinicopathological Features of Esophageal Squamous Cell Carcinomas in Patients With No History of Tobacco Smoking or Alcohol Consumption. | Tateishi Y et al. | β | 2025 | β |
| Global research landscapes of ALDH2 and cancer revealed by bibliometric analysis. | Zhang T et al. | β | 2025 | β |
| Immunoglobulin G (IgG) in oral submucous fibrosis and oral squamous cell carcinoma - An <i>ex vivo</i> study. | Tandon A et al. | β | 2025 | β |
| Proliferative verrucous and homogeneous Leukoplakias exhibit differential methylation patterns. | Herreros-Pomares A et al. | β | 2025 | β |
| The Significance of Screening Endoscopy at 2-Year Interval for Detecting Pharyngeal and Esophageal Cancer in the Japanese General Population. | Kashiwagi K et al. | β | 2025 | β |
| ALDH2 mutations and defense against genotoxic aldehydes in cancer and inherited bone marrow failure syndromes. | Woo AY et al. | β | 2024 | β |
| Risk of <i>de novo</i> esophageal cancer in liver transplant recipients: systematic review and meta-analysis. | Li S et al. | β | 2024 | β |
| Both Moderate and Heavy Alcohol Use Amplify the Adverse Cardiovascular Effects of Smoking in Young Patients with Hypertension. | Palatini P et al. | β | 2023 | β |
| Effects of activation of an alcohol metabolic gene, cigarette smoking, and alcohol intake on the incidence of metachronous gastric cancer in patients who underwent endoscopic resection for gastric cancer: A multicenter retrospective pilot study. | Abiko S et al. | β | 2023 | β |
| Impacts of ADH1B rs1229984 and ALDH2 rs671 polymorphisms on risks of alcohol-related disorder and cancer. | Chang TG et al. | β | 2023 | β |
| Mediation analysis unveils a carcinogenic effect of ADH1B rs1229984 through mechanisms other than change in drinking intensity: oesophageal cancer case-control study. | Sugimoto Y et al. | β | 2023 | β |
| Relationship between esophageal squamous cell carcinoma risk and alcohol-related ALDH2 and ADH1B polymorphisms: Evidence from a meta-analysis and Mendelian randomization analysis. | Zhang B et al. | β | 2023 | β |
| Risk for Esophageal Cancer Based on Lifestyle Factors-Smoking, Alcohol Consumption, and Body Mass Index: Insight from a South Korean Population Study in a Low-Incidence Area. | Kwon MJ et al. | β | 2023 | β |
| Alcohol metabolism genes and risks of site-specific cancers in Chinese adults: An 11-year prospective study. | Im PK et al. | β | 2022 | β |
| Decreased Expression of NRF2 Target Genes after Alcohol Exposure in the Background Esophageal Mucosa of Patients with Esophageal Squamous Cell Carcinoma. | Toda S et al. | β | 2022 | β |
| Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation? | Yu C et al. | β | 2022 | β |
| Does synchronous early head and neck cancer with esophageal cancer need treatment after preoperative chemotherapy? | Kanamori K et al. | β | 2022 | β |
| Update on Management of Squamous Cell Esophageal Cancer. | Waters JK et al. | β | 2022 | β |
| Upper Gastrointestinal Cancer and Liver Cirrhosis. | Jeng KS et al. | β | 2022 | β |
| A concise review towards defining the exposome of oesophageal cancer in sub-Saharan Africa. | Lipenga T et al. | β | 2021 | β |
| Alcohol Consumption and Cigarette Smoking among Young Adults: An Instrumental Variable Analysis Using Alcohol Flushing. | Jee Y et al. | β | 2021 | β |
| Bupivacaine inhibits the malignant biological behavior of oral squamous cell carcinoma cells by inhibiting the activation of ERK1/2 and STAT3. | Wang Z et al. | β | 2021 | β |
| Novel genomic alteration in superficial esophageal squamous cell neoplasms in non-smoker non-drinker females. | Onozato Y et al. | β | 2021 | β |
| Oncogenic SNORD12B activates the AKT-mTOR-4EBP1 signaling in esophageal squamous cell carcinoma via nucleus partitioning of PP-1Ξ±. | Tian B et al. | β | 2021 | β |
| Role of Oncofetal Protein CR-1 as aΒ Potential Tumor Marker for Oral Squamous Cell Carcinoma. | Jain A et al. | β | 2021 | β |
| The microbiome, genetics, and gastrointestinal neoplasms: the evolving field of molecular pathological epidemiology to analyze the tumor-immune-microbiome interaction. | Mima K et al. | β | 2021 | β |
| The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment. | Zhang H et al. | β | 2021 | β |
| The role of Hippo-YAP signaling in squamous cell carcinomas. | Maehama T et al. | β | 2021 | β |
| Aberrant DNA Methylation in Esophageal Squamous Cell Carcinoma: Biological and Clinical Implications. | Lin L et al. | β | 2020 | β |
| Genome-wide association study identifies new loci for albuminuria in the Japanese population. | Okuda H et al. | β | 2020 | β |
| Icariin Mitigates the Growth and Invasion Ability of Human Oral Squamous Cell Carcinoma via Inhibiting Toll-Like Receptor 4 and Phosphorylation of NF-ΞΊB P65. | Lei K et al. | β | 2020 | β |
| Identification and Characterization of Copy Number-Associated Driver Genes in Esophageal Squamous Cell Carcinoma. | Jiang K et al. | β | 2020 | β |
| Identification of Leukocyte telomere length-related genetic variants contributing to predisposition of Esophageal Squamous Cell Carcinoma. | Li Z et al. | β | 2020 | β |
| Impact of alcohol drinking on cancer risk with consideration of flushing response: The Japan Public Health Center-based Prospective Study Cohort (JPHC study). | Ono A et al. | β | 2020 | β |
| Impacts of interactions between ADH1B and ALDH2 genotypes on alcohol flushing, alcohol reeking on the day after drinking, and age distribution in Japanese alcohol-dependent men. | Yokoyama A et al. | β | 2020 | β |
| Relationships of early esophageal cancer with human papillomavirus and alcohol metabolism. | Inoue M et al. | β | 2020 | β |
| The Alcohol Use Disorders Identification Test and the risk of metachronous cancer after endoscopic resection of esophageal cancer. | Yokoyama A et al. | β | 2020 | β |
| A Model Shows Utility in Predicting Postoperative Recurrence and Distant Metastasis in Curatively Resected Esophageal Squamous Cell Cancer. | Wang W et al. | β | 2019 | β |
| Association of <i>ADH1B</i> Arg47His polymorphism with the risk of cancer: a meta-analysis. | Tan B et al. | β | 2019 | β |
| Effect of ALDH2 polymorphism on cancer risk in Asians: A meta-analysis. | Zuo W et al. | β | 2019 | β |
| Endoscopic screening using esophageal iodine staining and genotypes of ADH1B and ALDH2 in Japanese alcohol-dependent women. | Yokoyama A et al. | β | 2019 | β |
| Genetic determinants of beverage consumption: Implications for nutrition and health. | Cornelis MC | β | 2019 | β |
| Professional Oral Care Reduces Carcinogenic Acetaldehyde Levels in Mouth Air of Perioperative Esophageal Cancer Patients: A Prospective Comparative Study. | Tanda N et al. | β | 2019 | β |
| Quantitative Proteomics Identify the Possible Tumor Suppressive Role of Protease-Activated Receptor-4 in Esophageal Squamous Cell Carcinoma Cells. | Wang M et al. | β | 2019 | β |
| Revisit of an unanswered question by pooled analysis of eight cohort studies in Japan: Does cigarette smoking and alcohol drinking have interaction for the risk of esophageal cancer? | Oze I et al. | β | 2019 | β |
| Alcohol-Derived Acetaldehyde Exposure in the Oral Cavity. | Stornetta A et al. | β | 2018 | β |
| Alcohol-Induced Epigenetic Changes in Cancer. | Dumitrescu RG | β | 2018 | β |
| A mutational signature associated with alcohol consumption and prognostically significantly mutated driver genes in esophageal squamous cell carcinoma. | Li XC et al. | β | 2018 | β |
| Expanding primary cells from mucoepidermoid and other salivary gland neoplasms for genetic and chemosensitivity testing. | Alamri AM et al. | β | 2018 | β |
| Risk assessment of metachronous squamous cell carcinoma after endoscopic resection for esophageal carcinoma based on the genetic polymorphisms of alcoholdehydrogense-1B aldehyde dehydrogenase-2: temperance reduces the risk. | Abiko S et al. | β | 2018 | β |
| Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer. | Yokoyama A et al. | β | 2017 | β |
| Alcohol Intake More than Doubles the Risk of Early Cardiovascular Events in Young Hypertensive Smokers. | Palatini P et al. | β | 2017 | β |
| Alcohol metabolism and oesophageal cancer: a systematic review of the evidence. | Matejcic M et al. | β | 2017 | β |
| As a Novel Prognostic Marker, Cysteine/histidine-rich 1 (CYHR1) is a Therapeutic Target in Patients with Esophageal Squamous Cell Carcinoma. | Desaki R et al. | β | 2017 | β |
| Association of genotypes of rs671 within<i>ALDH2</i> with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas. | Zhang LQ et al. | β | 2017 | β |
| Candidate susceptibility variants for esophageal squamous cell carcinoma. | Donner I et al. | β | 2017 | β |
| Cross-Sectional Association of Salivary Proteins with Age, Sex, Body Mass Index, Smoking, and Education. | Murr A et al. | β | 2017 | β |
| GWAS follow-up study of esophageal squamous cell carcinoma identifies potential genetic loci associated with family history of upper gastrointestinal cancer. | Song X et al. | β | 2017 | β |
| Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk. | Sakiyama M et al. | β | 2017 | β |
| Recovery from anemia and leukocytopenia after abstinence in Japanese alcoholic men and their genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2. | Yokoyama A et al. | β | 2017 | β |
| Smoking Cessation and Risk of Esophageal Cancer by Histological Type: Systematic Review and Meta-analysis. | Wang QL et al. | β | 2017 | β |
| Soft palatal melanosis, a simple predictor for neoplasia in the upper aerodigestive tract in Japanese alcoholic men. | Hirata K et al. | β | 2017 | β |
| ADH1B and ALDH2 are associated with metachronous SCC after endoscopic submucosal dissection of esophageal squamous cell carcinoma. | Kagemoto K et al. | β | 2016 | β |
| Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a meta-analysis. | Mao N et al. | β | 2016 | β |
| Epigenetic field cancerization in gastrointestinal cancers. | Baba Y et al. | β | 2016 | β |
| Esophageal squamous cell cancer in a highly endemic region. | Asombang AW et al. | β | 2016 | β |
| Genomic Landscape of Esophageal Squamous Cell Carcinoma inΒ a Japanese Population. | Sawada G et al. | β | 2016 | β |
| Signatures of Mutational Processes and Associated Risk Factors in Esophageal Squamous Cell Carcinoma: A Geographically Independent Stratification Strategy? | Secrier M et al. | β | 2016 | β |
| Susceptibility to oral squamous cell carcinoma: correlation with variants of <i>CYP1A1-Msp</i>I, <i>GSTT1, GSTM1, ALDH2, EC-SOD and Lifestyle factors</i>. | Dong TT et al. | β | 2016 | β |
| The detective, prognostic, and predictive value of DNA methylation in human esophageal squamous cell carcinoma. | Ma K et al. | β | 2016 | β |
| Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. | Cai Q et al. | β | 2015 | β |
| Clinical significance of mediastinoscope-assisted transhiatal esophagectomy in patients with esophageal cancer. | Okumura H et al. | β | 2015 | β |
| Estimates of alcohol-related oesophageal cancer burden in Japan: systematic review and meta-analyses. | Roerecke M et al. | β | 2015 | β |
| Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking. | Eriksson CJ | β | 2015 | β |
| Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2, alcohol flushing, mean corpuscular volume, and aerodigestive tract neoplasia in Japanese drinkers. | Yokoyama A et al. | β | 2015 | β |
| Molecular mechanisms of ethanol-associated oro-esophageal squamous cell carcinoma. | Liu Y et al. | β | 2015 | β |
| ABCC4 copy number variation is associated with susceptibility to esophageal squamous cell carcinoma. | Sun Y et al. | β | 2014 | β |
| CYP1A1 and CYP2E1 genotypes and risk of esophageal squamous cell carcinoma in a high-incidence region, Kashmir. | Bhat GA et al. | β | 2014 | β |
| Epidemiological studies of esophageal cancer in the era of genome-wide association studies. | Wang AH et al. | β | 2014 | β |
| Gene-environment interactions on the risk of esophageal cancer among Asian populations with the G48A polymorphism in the alcohol dehydrogenase-2 gene: a meta-analysis. | Zhang L et al. | β | 2014 | β |
| Genetic variations in MTHFR and esophageal squamous cell carcinoma susceptibility in Chinese Han population. | Tang W et al. | β | 2014 | β |
| Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study. | Ahrens W et al. | β | 2014 | β |
| PLCE1 mRNA and protein expression and survival of patients with esophageal squamous cell carcinoma and gastric adenocarcinoma. | Li WQ et al. | β | 2014 | β |
| Single nucleotide polymorphism at alcohol dehydrogenase-1B is associated with risk of esophageal squamous cell carcinoma. | Ye B et al. | β | 2014 | β |
| Tag single nucleotide polymorphisms of alcohol-metabolizing enzymes modify the risk of upper aerodigestive tract cancers: HapMap database analysis. | Chung CS et al. | β | 2014 | β |
| A health-risk appraisal model and endoscopic mass screening for esophageal cancer in Japanese men. | Yokoyama A et al. | β | 2013 | β |
| Alcohol and acetaldehyde in African fermented milk mursik--a possible etiologic factor for high incidence of esophageal cancer in western Kenya. | Nieminen MT et al. | β | 2013 | β |
| ALDH2 genotype has no effect on salivary acetaldehyde without the presence of ethanol in the systemic circulation. | Helminen A et al. | β | 2013 | β |
| Association of CHRNA5-A3-B4 variation with esophageal squamous cell carcinoma risk and smoking behaviors in a Chinese population. | Wang Y et al. | β | 2013 | β |
| Epidemiology of esophageal cancer in Japan and China. | Lin Y et al. | β | 2013 | β |
| Gene profiling suggests a common evolution of bladder cancer subtypes. | Hansel DE et al. | β | 2013 | β |
| Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population. | Li WQ et al. | β | 2013 | β |
| Genetic variants in epidermal growth factor receptor pathway genes and risk of esophageal squamous cell carcinoma and gastric cancer in a Chinese population. | Li WQ et al. | β | 2013 | β |
| p53 immunohistochemical expression and patient prognosis in esophageal squamous cell carcinoma. | Murata A et al. | β | 2013 | β |
| The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer. | Matsuo K et al. | β | 2013 | β |
| A variant allele of ADH1B and ALDH2, is associated with the risk of esophageal cancer. | Gu H et al. | β | 2012 | β |
| Development of squamous neoplasia in esophageal iodine-unstained lesions and the alcohol and aldehyde dehydrogenase genotypes of Japanese alcoholic men. | Yokoyama A et al. | β | 2012 | β |
| Interaction between alcohol consumption and CYP 2C19 gene polymorphism in relation to oesophageal squamous cell carcinoma. | Shi Y et al. | β | 2012 | β |
| LINE-1 hypomethylation in noncancerous esophageal mucosae is associated with smoking history. | Shigaki H et al. | β | 2012 | β |
| Surveillance for gastrointestinal malignancies. | Tiwari AK et al. | β | 2012 | β |
| The genetics of substance dependence. | Wang JC et al. | β | 2012 | β |
| Acetaldehyde and gastric cancer. | Salaspuro M | β | 2011 | β |
| Genetic vulnerability and susceptibility to substance dependence. | Bierut LJ | β | 2011 | β |
| Revisit of field cancerization in squamous cell carcinoma of upper aerodigestive tract: better risk assessment with epigenetic markers. | Lee YC et al. | β | 2011 | β |