Temporal change in human nicotinic acetylcholine receptor after smoking cessation: 5IA SPECT study.
paper
Cited
Public
Unavailable
- Authors
- Mamede, Marcelo; Ishizu, Koichi; Ueda, Masashi; Mukai, Takahiro; Iida, Yasuhiko; Kawashima, Hidekazu; Fukuyama, Hidenao; Togashi, Kaori; Saji, Hideo
- Year
- 2007
- Journal
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- PMID
- 17942810
- DOI
- 10.2967/jnumed.107.043471
UNLABELLED: Nicotinic acetylcholine receptors (nAChRs) are of great interest because they are implicated in various brain functions. They also are thought to play an important role in nicotine addiction of smokers. Chronic (-)-nicotine, a nAChR agonist, treatment in mice and rats elicits a dose-dependent increase in nAChRs in the brain. Upregulation of nAChRs in postmortem human brains of smokers has also been reported. However, changes in nAChRs after cigarette smoking cessation in humans are poorly understood. The aim of this study was to detect the dynamic changes of nAChRs after smoking and smoking cessation in the brains of living subjects. METHODS: We performed 5-(123)I-iodo-A-85380 ((123)I-5IA) SPECT on nonsmokers and smokers (n = 16) who had quit smoking for 4 h, 10 d, and 21 d and calculated and compared distribution volumes (Vt) of (123)I-5IA. RESULTS: The binding potential of nAChRs (Vt of (123)I-5IA) in the brains of smokers decreased by 33.5% +/- 10.5% after 4 h of smoking cessation, increased by 25.7% +/- 9.2% after 10 d of smoking cessation, and decreased to the level of nonsmokers after 21 d of smoking cessation. CONCLUSION: Because the upregulation of the nAChRs of the smokers after chronic exposure of the nicotine was downregulated to the nonsmokers' level by around 21 d after smoking cessation, the upregulation is a temporary effect. The decrease in nicotinic receptors to nonsmoker levels may be the breaking point during the nicotine withdrawal period.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Multiple sources of Ξ²2*-nicotinic acetylcholine receptor binding are differentially affected during tobacco smoking abstinence as revealed by Independent Component Analysis of [<sup>18</sup>F]Flubatine PET images. | Raval NR et al. | β | 2026 | β |
| Smoking Experience before Adulthood Is Associated with an Increased Risk of Developing Ulcerative Colitis in Adult Ex-Smokers. | Jun YK et al. | β | 2025 | β |
| The causal mediating effect of smoking on the relationship between irritability and bipolar disorder: A two-step Mendelian randomization study. | Hu Q et al. | β | 2025 | β |
| E-Cigarette Dependence and Depressive Symptoms Among Youth. | Chaiton M et al. | β | 2024 | β |
| The Effects of a Healthy Lifestyle on Depressive Symptoms in Older Chinese Adults: The Mediating Role of Psychological Resilience. | Duan A et al. | β | 2024 | β |
| An application of the stress-diathesis model: A review about the association between smoking tobacco, smoking cessation, and mental health. | Taylor GMJ et al. | β | 2023 | β |
| Cholinergic system adaptations are associated with cognitive function in people recently abstinent from smoking: a (-)-[<sup>18</sup>F]flubatine PET study. | Calakos KC et al. | β | 2023 | β |
| Overexpression of Cancer- and Neurotransmitter-Associated Genes in the Nucleus Accumbens of Smokers | Stein R et al. | β | 2022 | β |
| The effects of smoking habit change on the risk of depression-Analysis of data from the Korean National Health Insurance Service. | Kim GE et al. | β | 2022 | β |
| The protective role of cigarette smoking against Parkinson's disease via moderation of the interaction between iron deposition in the nigrostriatal pathway and clinical symptoms. | Gu Q et al. | β | 2022 | β |
| TOBACCO USE DISORDER AND DUAL DISORDERS Joint statement by the Spanish Psychiatry Society and the Spanish Dual Disorders Society. | NΓ©stor S et al. | β | 2022 | β |
| Addiction-related neuroadaptations following chronic nicotine exposure. | Wills L et al. | β | 2021 | β |
| Addressing concerns about smoking cessation and mental health: theoretical review and practical guide for healthcare professionals. | Taylor GMJ et al. | β | 2021 | β |
| Smoking cessation for improving mental health. | Taylor GM et al. | β | 2021 | β |
| Do Nicotinic Receptors Modulate High-Order Cognitive Processing? | Koukouli F et al. | β | 2020 | β |
| Ξ²4-Nicotinic Receptors Are Critically Involved in Reward-Related Behaviors and Self-Regulation of Nicotine Reinforcement. | Husson M et al. | β | 2020 | β |
| Chronic Nicotine Exposure Alters the Neurophysiology of Habenulo-Interpeduncular Circuitry. | Arvin MC et al. | β | 2019 | β |
| Neuropeptide CART prevents memory loss attributed to withdrawal of nicotine following chronic treatment in mice. | Borkar CD et al. | β | 2019 | β |
| Cognitive Effects of Nicotine: Recent Progress. | Valentine G et al. | β | 2018 | β |
| A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. | Jensen KP et al. | β | 2017 | β |
| Epigenetic dysregulation of protocadherins in human disease. | El Hajj N et al. | β | 2017 | β |
| Age-related changes in functional postsynaptic nicotinic acetylcholine receptor subunits in neurons of the laterodorsal tegmental nucleus, a nucleus important in drug addiction. | Christensen MH et al. | β | 2016 | β |
| [Development of Radiolabeled Molecular Imaging Probes for in Vivo Analysis of Biological Function]. | Ueda M | β | 2016 | β |
| Nicotinic acetylcholine receptor availability in cigarette smokers: effect of heavy caffeine or marijuana use. | Brody AL et al. | β | 2016 | β |
| Nicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug use. | Melroy-Greif WE et al. | β | 2016 | β |
| Bacoside A: Role in Cigarette Smoking Induced Changes in Brain. | Vani G et al. | β | 2015 | β |
| Imaging Tobacco Smoking with PET and SPECT. | Cosgrove KP et al. | β | 2015 | β |
| Inside-out neuropharmacology of nicotinic drugs. | Henderson BJ et al. | β | 2015 | β |
| Nicotinic receptor contributions to smoking: insights from human studies and animal models. | Brunzell DH et al. | β | 2015 | β |
| Brain nicotinic acetylcholine receptor availability and response to smoking cessation treatment: a randomized trial. | Brody AL et al. | β | 2014 | β |
| Change in mental health after smoking cessation: systematic review and meta-analysis. | Taylor G et al. | β | 2014 | β |
| COPI polices nicotine-mediated up-regulation of nicotinic receptors. | Anand R | β | 2014 | β |
| Donepezil reverses nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6J mice. | Poole RL et al. | β | 2014 | β |
| Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans. | Jasinska AJ et al. | β | 2014 | β |
| Involvement of neuronal Ξ²2 subunit-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal: implications for pharmacotherapies. | Simmons SJ et al. | β | 2014 | β |
| Nicotine exploits a COPI-mediated process for chaperone-mediated up-regulation of its receptors. | Henderson BJ et al. | β | 2014 | β |
| Pharmacological chaperoning of nAChRs: a therapeutic target for Parkinson's disease. | Srinivasan R et al. | β | 2014 | β |
| Whole tobacco smoke extracts to model tobacco dependence in animals. | Brennan KA et al. | β | 2014 | β |
| A positive relationship between harm avoidance and brain nicotinic acetylcholine receptor availability. | Storage S et al. | β | 2013 | β |
| Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia. | Young JW et al. | β | 2013 | β |
| High-affinity nicotinic acetylcholine receptor expression and trafficking abnormalities in psychiatric illness. | Lewis AS et al. | β | 2013 | β |
| Therapeutic vaccines against tobacco addiction. | Fahim RE et al. | β | 2013 | β |
| Treatment for tobacco dependence: effect on brain nicotinic acetylcholine receptor density. | Brody AL et al. | β | 2013 | β |
| Up-regulation of nicotinic acetylcholine receptors in menthol cigarette smokers. | Brody AL et al. | β | 2013 | β |
| [No to "habit", yes to "addiction". Critical analysis of a tobacco-associated euphemism]. | Fonseca F et al. | β | 2012 | β |
| The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation. | Gould TJ et al. | β | 2012 | β |
| Effect of secondhand smoke on occupancy of nicotinic acetylcholine receptors in brain. | Brody AL et al. | β | 2011 | β |
| In vivo relationship between thalamic nicotinic acetylcholine receptor occupancy rates and antiallodynic effects in a rat model of neuropathic pain: persistent agonist binding inhibits the expression of antiallodynic effects. | Ueda M et al. | β | 2011 | β |
| Quantitative Molecular Imaging of Neuronal Nicotinic Acetylcholine Receptors in the Human Brain with A-85380 Radiotracers. | Lotfipour S et al. | β | 2011 | β |
| Imaging receptor changes in human drug abusers. | Cosgrove KP | β | 2010 | β |
| Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects. | Ueda M et al. | β | 2010 | β |
| Smoking-induced change in intrasynaptic dopamine concentration: effect of treatment for Tobacco Dependence. | Brody AL et al. | β | 2010 | β |
| Smoking, nicotine and neuropsychiatric disorders. | Dome P et al. | β | 2010 | β |
| beta2-Nicotinic acetylcholine receptor availability during acute and prolonged abstinence from tobacco smoking. | Cosgrove KP et al. | β | 2009 | β |
| Central in vivo nicotinic acetylcholine receptor imaging agents for positron emission tomography (PET) and single photon emission computed tomography (SPECT). | Ogawa M et al. | β | 2009 | β |
| Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. | Greenbaum L et al. | β | 2009 | β |
| Nicotine dependence: biology, behavior, and treatment. | Ray R et al. | β | 2009 | β |
| Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery. | Lester HA et al. | β | 2009 | β |
| Single photon emission computed tomography experience with (S)-5-[(123)I]iodo-3-(2-azetidinylmethoxy)pyridine in the living human brain of smokers and nonsmokers. | BrasiΔ JR et al. | β | 2009 | β |
| Greater nicotinic acetylcholine receptor density in smokers than in nonsmokers: a PET study with 2-18F-FA-85380. | Mukhin AG et al. | β | 2008 | β |
| Neuroimaging, genetics and the treatment of nicotine addiction. | Ray R et al. | β | 2008 | β |
| Varenicline ameliorates nicotine withdrawal-induced learning deficits in C57BL/6 mice. | Raybuck JD et al. | β | 2008 | β |