The role of notch in promoting glial and neural stem cell fates.
paper
Cited
Public
Unavailable
- Authors
- Gaiano, Nicholas; Fishell, Gord
- Year
- 2002
- Journal
- Annual review of neuroscience
- PMID
- 12052917
- DOI
- 10.1146/annurev.neuro.25.030702.130823
The Notch signaling pathway has long been known to influence cell fate in the developing nervous system. However, this pathway has generally been thought to inhibit the specification of certain cell types in favor of others, or to simply maintain a progenitor pool. Recently, this view has been challenged by numerous studies suggesting that Notch may play an instructive role in promoting glial development. This work has inspired a new look at the role of Notch signaling in specifying cell fate. It has also prompted further consideration of the emerging view that in some contexts glia may be multipotent progenitors. This review examines the role of Notch during gliogenesis in both fruit flies and vertebrates, as well as evidence in vertebrates that some glia may be stem cells.
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| Reelin regulates differentiation of neural stem cells by activation of notch signaling through Disabled-1 tyrosine phosphorylation. | Keilani S et al. | β | 2012 | β |
| Retinoic acid-dependent signaling pathways and lineage events in the developing mouse spinal cord. | Paschaki M et al. | β | 2012 | β |
| RNAi-mediated knock-down of Dab and Numb attenuate AΞ² levels via Ξ³-secretase mediated APP processing. | Xie Z et al. | β | 2012 | β |
| The cis side of juxtacrine signaling: a new role in the development of the nervous system. | Yaron A et al. | β | 2012 | β |
| The identification of transcriptional targets of Ascl1 in oligodendrocyte development. | Ueno T et al. | β | 2012 | β |
| The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma. | Chen L et al. | β | 2012 | β |
| Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. | Gokoffski KK et al. | β | 2011 | β |
| A systems biology approach to model neural stem cell regulation by notch, shh, wnt, and EGF signaling pathways. | Sivakumar KC et al. | β | 2011 | β |
| Biophysics of substrate interaction: influence on neural motility, differentiation, and repair. | Moore SW et al. | β | 2011 | β |
| Caveolin-1 promote astroglial differentiation of neural stem/progenitor cells through modulating Notch1/NICD and Hes1 expressions. | Li Y et al. | β | 2011 | β |
| Characterization of olfactory stem cells. | Wetzig A et al. | β | 2011 | β |
| Dermatan sulfotransferase Chst14/D4st1, but not chondroitin sulfotransferase Chst11/C4st1, regulates proliferation and neurogenesis of neural progenitor cells. | Bian S et al. | β | 2011 | β |
| Forced notch signaling inhibits commissural axon outgrowth in the developing chick central nerve system. | Shi M et al. | β | 2011 | β |
| Glial S100B protein modulates mutant ataxin-1 aggregation and toxicity: TRTK12 peptide, a potential candidate for SCA1 therapy. | Vig PJ et al. | β | 2011 | β |
| Human stem/progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor Ξ² and Notch signaling. | Robinson AP et al. | β | 2011 | β |
| Mediators of oligodendrocyte differentiation during remyelination. | Patel JR et al. | β | 2011 | β |
| Neural differentiation from human embryonic stem cells as a tool to study early brain development and the neuroteratogenic effects of ethanol. | TalΓ©ns-Visconti R et al. | β | 2011 | β |
| Neurodegenerative disease and adult neurogenesis. | Winner B et al. | β | 2011 | β |
| Noggin and Wnt3a enable BMP4-dependent differentiation of telencephalic stem cells into GluR-agonist responsive neurons. | Andersson T et al. | β | 2011 | β |
| Noise induced changes in the expression of p38/MAPK signaling proteins in the sensory epithelium of the inner ear. | Jamesdaniel S et al. | β | 2011 | β |
| Notch in the vertebrate nervous system: an old dog with new tricks. | Pierfelice T et al. | β | 2011 | β |
| RBP-J promotes the maturation of neuronal progenitors. | Komine O et al. | β | 2011 | β |
| Regulation of cortical neuron migration by the Reelin signaling pathway. | Honda T et al. | β | 2011 | β |
| Simulated microgravity promoted differentiation of bipotential murine oval liver stem cells by modulating BMP4/Notch1 signaling. | Majumder S et al. | β | 2011 | β |
| Sonic hedgehog and notch signaling can cooperate to regulate neurogenic divisions of neocortical progenitors. | Dave RK et al. | β | 2011 | β |
| Transcriptional characterization of Wnt and Notch signaling pathways in neuronal differentiation of human adipose tissue-derived stem cells. | Cardozo AJ et al. | β | 2011 | β |
| Arsenic trioxide-mediated Notch pathway inhibition depletes the cancer stem-like cell population in gliomas. | Zhen Y et al. | β | 2010 | β |
| Brain tumor stem cells as therapeutic targets in models of glioma. | Laks DR et al. | β | 2010 | β |
| Connecting vascular and nervous system development: angiogenesis and the blood-brain barrier. | Tam SJ et al. | β | 2010 | β |
| Controversies in cancer stem cells: targeting embryonic signaling pathways. | Takebe N et al. | β | 2010 | β |
| CREBBP re-arrangements affect protein function and lead to aberrant neuronal differentiation. | Sharma N et al. | β | 2010 | β |
| Differential expression of Shh and BMP signaling in the potential conversion of human adipose tissue stem cells into neuron-like cells in vitro. | Cardozo A et al. | β | 2010 | β |
| Glioma stem cell signaling: therapeutic opportunities and challenges. | Dietrich J et al. | β | 2010 | β |
| Heterogeneity in ventricular zone neural precursors contributes to neuronal fate diversity in the postnatal neocortex. | Stancik EK et al. | β | 2010 | β |
| Interaction of hypoxia-inducible factor-1Ξ± and Notch signaling regulates medulloblastoma precursor proliferation and fate. | Pistollato F et al. | β | 2010 | β |
| Involvement of Notch1 inhibition in serum-stimulated glia and oligodendrocyte differentiation from human mesenchymal stem cells. | Lee YJ et al. | β | 2010 | β |
| Isolation of cancer stem-like cells from a side population of a human glioblastoma cell line, SK-MG-1. | Fukaya R et al. | β | 2010 | β |
| Jagged1 expression regulated by Notch3 and Wnt/Ξ²-catenin signaling pathways in ovarian cancer. | Chen X et al. | β | 2010 | β |
| Notch exhibits ligand bias and maneuvers stage-specific steering of neural differentiation in embryonic stem cells. | Ramasamy SK et al. | β | 2010 | β |
| NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts. | Fan X et al. | β | 2010 | β |
| Notch signaling influences neuroprotective and proliferative properties of mature MΓΌller glia. | Ghai K et al. | β | 2010 | β |
| Notch signaling in solid tumors. | Koch U et al. | β | 2010 | β |
| Notch signaling: key role in intrauterine infection/inflammation, embryonic development, and white matter damage? | Yuan TM et al. | β | 2010 | β |
| Notch signalling regulates the contribution of progenitor cells from the chick Hensen's node to the floor plate and notochord. | Gray SD et al. | β | 2010 | β |
| Presenilin/gamma-Secretase and Inflammation. | Saura CA | β | 2010 | β |
| Proteomics comparison of cerebrospinal fluid of relapsing remitting and primary progressive multiple sclerosis. | Stoop MP et al. | β | 2010 | β |
| Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. | Bernard F et al. | β | 2010 | β |
| Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. | Shiwaku H et al. | β | 2010 | β |
| The functional role of Notch signaling in human gliomas. | Stockhausen MT et al. | β | 2010 | β |
| The perivascular niche microenvironment in brain tumor progression. | Charles N et al. | β | 2010 | β |
| Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain. | Shimizu T et al. | β | 2010 | β |
| ATP-dependent chromatin remodeling in neural development. | Yoo AS et al. | β | 2009 | β |
| Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord. | Iulianella A et al. | β | 2009 | β |
| DeltaA mRNA and protein distribution in the zebrafish nervous system. | Tallafuss A et al. | β | 2009 | β |
| DNA copy number variation and gene expression analyses reveal the implication of specific oncogenes and genes in GBM. | Margareto J et al. | β | 2009 | β |
| Dynamic signaling for neural stem cell fate determination. | Wen S et al. | β | 2009 | β |
| Emerging cues mediating astroglia lineage restriction of progenitor cells in the injured/diseased adult CNS. | Teng FY et al. | β | 2009 | β |
| Future use of mitocans against tumour-initiating cells? | Morrison BJ et al. | β | 2009 | β |
| Late origin of glia-restricted progenitors in the developing mouse cerebral cortex. | Costa MR et al. | β | 2009 | β |
| Mammalian Par3 regulates progenitor cell asymmetric division via notch signaling in the developing neocortex. | Bultje RS et al. | β | 2009 | β |
| Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells. | Ma DK et al. | β | 2009 | β |
| Neocortical neurogenesis: morphogenetic gradients and beyond. | Caviness VS et al. | β | 2009 | β |
| Notch activation induces neurite remodeling and functional modifications in SH-SY5Y neuronal cells. | Ferrari-Toninelli G et al. | β | 2009 | β |
| Notch signaling confers antigen-presenting cell functions on mast cells. | Nakano N et al. | β | 2009 | β |
| Periventricular notch activation and asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cells. | Ochiai W et al. | β | 2009 | β |
| Pilocytic astrocytoma of the optic pathway: a tumour deriving from radial glia cells with a specific gene signature. | Tchoghandjian A et al. | β | 2009 | β |
| Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. | Hirabayashi Y et al. | β | 2009 | β |
| Reversine increases the plasticity of lineage-committed cells toward neuroectodermal lineage. | Lee EK et al. | β | 2009 | β |
| Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway. | Xu J et al. | β | 2009 | β |
| The development of developmental neuroscience. | Mason C | β | 2009 | β |
| The glial nature of embryonic and adult neural stem cells. | Kriegstein A et al. | β | 2009 | β |
| The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke. | Wang L et al. | β | 2009 | β |
| Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways. | Li Z et al. | β | 2009 | β |
| Astrocyte, the star avatar: redefined. | Seth P et al. | β | 2008 | β |
| Brain micro-ecologies: neural stem cell niches in the adult mammalian brain. | Riquelme PA et al. | β | 2008 | β |
| Brain tumor stem cells as research and treatment targets. | Hide T et al. | β | 2008 | β |
| Brain tumor stem cells: bringing order to the chaos of brain cancer. | Dirks PB | β | 2008 | β |
| Breast cancer stem cells: implications for therapy of breast cancer. | Morrison BJ et al. | β | 2008 | β |
| Correlative analyses of notch signaling with resveratrol-induced differentiation and apoptosis of human medulloblastoma cells. | Wang Q et al. | β | 2008 | β |
| Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition. | Kageyama R et al. | β | 2008 | β |
| Effects of folate on notch signaling and cell proliferation in neural stem cells of neonatal rats in vitro. | Zhang X et al. | β | 2008 | β |
| Expression of Notch-1 receptor and its ligands Jagged-1 and Delta-1 in amoeboid microglia in postnatal rat brain and murine BV-2 cells. | Cao Q et al. | β | 2008 | β |
| Hes6 controls cell proliferation via interaction with cAMP-response element-binding protein-binding protein in the promyelocytic leukemia nuclear body. | Eun B et al. | β | 2008 | β |
| Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors. | Bonilla S et al. | β | 2008 | β |
| Methylmercury inhibits differentiation of rat neural stem cells via Notch signalling. | Tamm C et al. | β | 2008 | β |
| Morphological and functional characterization of predifferentiation of myelinating glia-like cells from human bone marrow stromal cells through activation of F3/Notch signaling in mouse retina. | Lu L et al. | β | 2008 | β |
| Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium. | Rodriguez S et al. | β | 2008 | β |
| Notch, neural stem cells, and brain tumors. | Pierfelice TJ et al. | β | 2008 | β |
| Oscillations in notch signaling regulate maintenance of neural progenitors. | Shimojo H et al. | β | 2008 | β |
| Polysialic acid regulates the clustering, migration, and neuronal differentiation of progenitor cells in the adult hippocampus. | Burgess A et al. | β | 2008 | β |
| Radial glia and neural stem cells. | Malatesta P et al. | β | 2008 | β |
| Reelin induces a radial glial phenotype in human neural progenitor cells by activation of Notch-1. | Keilani S et al. | β | 2008 | β |
| Regulation of neural progenitor cell development in the nervous system. | Corbin JG et al. | β | 2008 | β |
| Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon. | Kawaguchi D et al. | β | 2008 | β |
| The neuro-glial properties of adipose-derived adult stromal (ADAS) cells are not regulated by Notch 1 and are not derived from neural crest lineage. | Wrage PC et al. | β | 2008 | β |
| The transcriptome of retinal MΓΌller glial cells. | Roesch K et al. | β | 2008 | β |
| Understanding stem cell differentiation through self-organization theory. | Qu K et al. | β | 2008 | β |
| A novel function of DELTA-NOTCH signalling mediates the transition from proliferation to neurogenesis in neural progenitor cells. | HΓ€mmerle B et al. | β | 2007 | β |
| Astrogliosis in EAE spinal cord: derivation from radial glia, and relationships to oligodendroglia. | Bannerman P et al. | β | 2007 | β |
| Asymmetric cell division during brain morphogenesis. | Miyata T | β | 2007 | β |
| Asymmetric localization of Notch2 on the microvillous surface in choroid plexus epithelial cells. | Tanaka M et al. | β | 2007 | β |
| Clustering, migration, and neurite formation of neural precursor cells in the adult rat hippocampus. | Seki T et al. | β | 2007 | β |
| Current and potential rodent screens and tests for thyroid toxicants. | Zoeller RT et al. | β | 2007 | β |
| Differential Notch signalling distinguishes neural stem cells from intermediate progenitors. | Mizutani K et al. | β | 2007 | β |
| Environmental chemicals impacting the thyroid: targets and consequences. | Zoeller RT | β | 2007 | β |
| Gene expression profiling of human gliomas reveals differences between GBM and LGA related to energy metabolism and notch signaling pathways. | Margareto J et al. | β | 2007 | β |
| Identification of Notch-1 expression in the limbal basal epithelium. | Thomas PB et al. | β | 2007 | β |
| Influence of thyroid hormones on maturation of rat cerebellar astrocytes. | Manzano J et al. | β | 2007 | β |
| Inhibition of cortical astrocyte differentiation by Hes6 requires amino- and carboxy-terminal motifs important for dimerization and phosphorylation. | Belanger-Jasmin S et al. | β | 2007 | β |
| In search of the medulloblast: neural stem cells and embryonal brain tumors. | Eberhart CG | β | 2007 | β |
| Loss of testicular orphan receptor 4 impairs normal myelination in mouse forebrain. | Zhang Y et al. | β | 2007 | β |
| Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. | Vooijs M et al. | β | 2007 | β |
| Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner. | Schouwey K et al. | β | 2007 | β |
| Notch signaling. | Hess S et al. | β | 2007 | β |
| Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish. | Shin J et al. | β | 2007 | β |
| Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors. | Rasin MR et al. | β | 2007 | β |
| Selective targeting of cancer stem cells: a new concept in cancer therapeutics. | Korkaya H et al. | β | 2007 | β |
| The adult neural stem cell niche: lessons for future neural cell replacement strategies. | Lim DA et al. | β | 2007 | β |
| The expression and functions of glycoconjugates in neural stem cells. | Yanagisawa M et al. | β | 2007 | β |
| The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling. | Komine O et al. | β | 2007 | β |
| The radial edifice of cortical architecture: from neuronal silhouettes to genetic engineering. | Rakic P | β | 2007 | β |
| Thrombin inhibits aquaporin 4 expression through protein kinase C-dependent pathway in cultured astrocytes. | Tang Y et al. | β | 2007 | β |
| Transcriptional characterization of the Notch signaling pathway in rodent multipotent adult progenitor cells. | Hajdu M et al. | β | 2007 | β |
| Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells. | Nelson BR et al. | β | 2007 | β |
| Bone marrow stromal cells induce BMP2/4 production in oxygen-glucose-deprived astrocytes, which promotes an astrocytic phenotype in adult subventricular progenitor cells. | Xin H et al. | β | 2006 | β |
| Cerebellar regulation mechanisms learned from studies on GluRdelta2. | Hirano T | β | 2006 | β |
| Cloning, characterization and promoter analysis of common carp hairy/Enhancer-of-split-related gene, her6. | Liu J et al. | β | 2006 | β |
| Collision of basic and applied approaches to risk assessment of thyroid toxicants. | Zoeller RT | β | 2006 | β |
| Cross-talk between F3/contactin and Notch at axoglial interface: a role in oligodendrocyte development. | Hu QD et al. | β | 2006 | β |
| Endocytosis-independent mechanisms of Delta ligand proteolysis. | Delwig A et al. | β | 2006 | β |
| Ethanol exposure during embryogenesis decreases the radial glial progenitorpool and affects the generation of neurons and astrocytes. | Rubert G et al. | β | 2006 | β |
| Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments. | Soen Y et al. | β | 2006 | β |
| From radial glia to pyramidal-projection neuron: transcription factor cascades in cerebral cortex development. | Hevner RF | β | 2006 | β |
| Hes6 inhibits astrocyte differentiation and promotes neurogenesis through different mechanisms. | Jhas S et al. | β | 2006 | β |
| Increased generation of neuronal progenitors after ischemic injury in the aged adult human forebrain. | Macas J et al. | β | 2006 | β |
| Mapping of notch activation during cochlear development in mice: implications for determination of prosensory domain and cell fate diversification. | Murata J et al. | β | 2006 | β |
| Neural crest stem and progenitor cells. | Crane JF et al. | β | 2006 | β |
| Neural induction: 10 years on since the 'default model'. | Stern CD | β | 2006 | β |
| Neural stem/progenitor cells participate in the regenerative response to perinatal hypoxia/ischemia. | Felling RJ et al. | β | 2006 | β |
| Notch1 functions to suppress cone-photoreceptor fate specification in the developing mouse retina. | Yaron O et al. | β | 2006 | β |
| Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. | Yang X et al. | β | 2006 | β |
| Notch3 signaling initiates choroid plexus tumor formation. | Dang L et al. | β | 2006 | β |
| Notch3 signaling promotes radial glial/progenitor character in the mammalian telencephalon. | Dang L et al. | β | 2006 | β |
| Notch, epidermal growth factor receptor, and beta1-integrin pathways are coordinated in neural stem cells. | Campos LS et al. | β | 2006 | β |
| Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors. | Fan X et al. | β | 2006 | β |
| Notch signaling in stem cell systems. | Chiba S | β | 2006 | β |
| Overexpression of SOCS3 inhibits astrogliogenesis and promotes maintenance of neural stem cells. | Cao F et al. | β | 2006 | β |
| Polypyrimidine tract binding protein and Notch1 are independently re-expressed in glioma. | Cheung HC et al. | β | 2006 | β |
| Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain. | Sardi SP et al. | β | 2006 | β |
| The bHLH transcription factors, Hes6 and Mash1, are expressed in distinct subsets of cells within adult mouse taste buds. | Seta Y et al. | β | 2006 | β |
| The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. | Kiernan AE et al. | β | 2006 | β |
| The realized niche of adult neural stem cells. | Nern C et al. | β | 2006 | β |
| Transcription factors in glutamatergic neurogenesis: conserved programs in neocortex, cerebellum, and adult hippocampus. | Hevner RF et al. | β | 2006 | β |
| Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta. | Ostroukhova M et al. | β | 2006 | β |
| Visualization of APP dimerization and APP-Notch2 heterodimerization in living cells using bimolecular fluorescence complementation. | Chen CD et al. | β | 2006 | β |
| Visualization of embryonic neural stem cells using Hes promoters in transgenic mice. | Ohtsuka T et al. | β | 2006 | β |
| Activated notch disrupts the initial patterning of dopaminergic spinal cord neurons. | Binor E et al. | β | 2005 | β |
| Adult neurogenesis: from precursors to network and physiology. | Abrous DN et al. | β | 2005 | β |
| A mutually stimulating loop involving emx2 and canonical wnt signalling specifically promotes expansion of occipital cortex and hippocampus. | Muzio L et al. | β | 2005 | β |
| Amyloid precursor protein interacts with notch receptors. | Oh SY et al. | β | 2005 | β |
| A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis. | Fior R et al. | β | 2005 | β |
| Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. | Anthony TE et al. | β | 2005 | β |
| Bre1 is required for Notch signaling and histone modification. | Bray S et al. | β | 2005 | β |
| Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease. | Lovell MA et al. | β | 2005 | β |
| Embryonic stem cell models of CAG repeat disease. | Lorincz MT | β | 2005 | β |
| Environmental chemicals as thyroid hormone analogues: new studies indicate that thyroid hormone receptors are targets of industrial chemicals? | Zoeller RT | β | 2005 | β |
| Epithelial stem cells and their niche: there's no place like home. | Rizvi AZ et al. | β | 2005 | β |
| Expanding roles of programmed cell death in mammalian neurodevelopment. | De Zio D et al. | β | 2005 | β |
| Glial influences on neural stem cell development: cellular niches for adult neurogenesis. | Ma DK et al. | β | 2005 | β |
| Hairy is a cell context signal controlling Notch activity. | Cui Y | β | 2005 | β |
| Histone deacetylase 1 regulates retinal neurogenesis in zebrafish by suppressing Wnt and Notch signaling pathways. | Yamaguchi M et al. | β | 2005 | β |
| Maternal thyroid hormone increases HES expression in the fetal rat brain: an effect mimicked by exposure to a mixture of polychlorinated biphenyls (PCBs). | Bansal R et al. | β | 2005 | β |
| Membrane properties of retinal stem cells/progenitors. | Das AV et al. | β | 2005 | β |
| Molecules affecting myelin stability: a novel hypothesis regarding the pathogenesis of multiple sclerosis. | Mastronardi FG et al. | β | 2005 | β |
| Notch-Delta signaling is required for spatial patterning and MΓΌller glia differentiation in the zebrafish retina. | Bernardos RL et al. | β | 2005 | β |
| Notch in the pathway: the roles of Notch signaling in neural crest development. | Cornell RA et al. | β | 2005 | β |
| Notch signaling, brain development, and human disease. | Lasky JL et al. | β | 2005 | β |
| Notch signaling in the mammalian central nervous system: insights from mouse mutants. | Yoon K et al. | β | 2005 | β |
| Progenitors resume generating neurons after temporary inhibition of neurogenesis by Notch activation in the mammalian cerebral cortex. | Mizutani K et al. | β | 2005 | β |
| Radial 'glial' progenitors: neurogenesis and signaling. | Ever L et al. | β | 2005 | β |
| Regulation of neural progenitor proliferation and survival by beta1 integrins. | Leone DP et al. | β | 2005 | β |
| Role of PROP1 in pituitary gland growth. | Ward RD et al. | β | 2005 | β |
| Roles of bHLH genes in neural stem cell differentiation. | Kageyama R et al. | β | 2005 | β |
| The adult pituitary contains a cell population displaying stem/progenitor cell and early embryonic characteristics. | Chen J et al. | β | 2005 | β |
| Visualization of spatiotemporal activation of Notch signaling: live monitoring and significance in neural development. | Kohyama J et al. | β | 2005 | β |
| XenDB: full length cDNA prediction and cross species mapping in Xenopus laevis. | Sczyrba A et al. | β | 2005 | β |
| A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. | Hadland BK et al. | β | 2004 | β |
| Conference report--stem cells and neurologic repair: highlights from the annual meeting of the American Society of Neuroscience; November 8-12, 2003; New Orleans, Louisiana. | Mariani SM | β | 2004 | β |
| Developmental neurobiology and the origin of brain tumors. | Shih AH et al. | β | 2004 | β |
| Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression. | Raetzman LT et al. | β | 2004 | β |
| Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. | Yoon K et al. | β | 2004 | β |
| Gap junctional communication is required to maintain mouse cortical neural progenitor cells in a proliferative state. | Cheng A et al. | β | 2004 | β |
| Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. | Kamakura S et al. | β | 2004 | β |
| Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. | Hatakeyama J et al. | β | 2004 | β |
| Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. | Merdes G et al. | β | 2004 | β |
| Mapping spatio-temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain. | Tokunaga A et al. | β | 2004 | β |
| Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway. | Gazit R et al. | β | 2004 | β |
| Mechanisms of glial development. | Colognato H et al. | β | 2004 | β |
| Minireview: Development and differentiation of gut endocrine cells. | Schonhoff SE et al. | β | 2004 | β |
| NELL2 promotes motor and sensory neuron differentiation and stimulates mitogenesis in DRG in vivo. | Nelson BR et al. | β | 2004 | β |
| [Neurogenesis in the adult brain: the demise of a dogma and the advent of new treatments]. | Crespel A et al. | β | 2004 | β |
| Notch1 and notch2 have opposite effects on embryonal brain tumor growth. | Fan X et al. | β | 2004 | β |
| Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. | Yang X et al. | β | 2004 | β |
| Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis. | Oishi K et al. | β | 2004 | β |
| Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells. | Irvin DK et al. | β | 2004 | β |
| Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. | Koo EH et al. | β | 2004 | β |
| The zebrafish as a model of heart regeneration. | Raya A et al. | β | 2004 | β |
| Three modules of zebrafish Mind bomb work cooperatively to promote Delta ubiquitination and endocytosis. | Chen W et al. | β | 2004 | β |
| Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1. | Jensen CH et al. | β | 2004 | β |
| Understanding glial differentiation in vertebrate nervous system development. | Wakamatsu Y | β | 2004 | β |
| Activation of Notch signaling pathway precedes heart regeneration in zebrafish. | Raya A et al. | β | 2003 | β |
| Astrocytes as stem cells: nomenclature, phenotype, and translation. | Steindler DA et al. | β | 2003 | β |
| Biology and clinical application of neural stem cells. | Shimazaki T | β | 2003 | β |
| Blood vessels and nerves: common signals, pathways and diseases. | Carmeliet P | β | 2003 | β |
| Cell adhesion molecules during inner ear and hair cell development, including notch and its ligands. | Kelley MW | β | 2003 | β |
| Elusive radial glial cells: historical and evolutionary perspective. | Rakic P | β | 2003 | β |
| From cells to circuits: development of the zebrafish spinal cord. | Lewis KE et al. | β | 2003 | β |
| Glial cells generate neurons--master control within CNS regions: developmental perspectives on neural stem cells. | GΓΆtz M | β | 2003 | β |
| Gliogenic and neurogenic progenitors of the subventricular zone: who are they, where did they come from, and where are they going? | Marshall CAG et al. | β | 2003 | β |
| Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks. | Karsten SL et al. | β | 2003 | β |
| Growth hormone and endocrinology. Proceedings of the 14th Novo Nordisk Symposium and of the SGA Satellite Symposium. March 28-29. Estroil/Lisbon, Portugal. | β | β | 2003 | β |
| HGF-, EGF-, and dexamethasone-induced gene expression patterns during formation of tissue in hepatic organoid cultures. | Michalopoulos GK et al. | β | 2003 | β |
| Neurogenesis and the cell cycle. | Ohnuma S et al. | β | 2003 | β |
| Neurons from radial glia: the consequences of asymmetric inheritance. | Fishell G et al. | β | 2003 | β |
| Notch activates sonic hedgehog and both are involved in the specification of dorsal midline cell-fates in Xenopus. | LΓ³pez SL et al. | β | 2003 | β |
| Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. | Selkoe D et al. | β | 2003 | β |
| Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions. | Seta Y et al. | β | 2003 | β |
| Notch signaling: a rheostat regulating oligodendrocyte differentiation? | Popko B | β | 2003 | β |
| Notch signaling in kidney development. | McCright B | β | 2003 | β |
| SOX2 functions to maintain neural progenitor identity. | Graham V et al. | β | 2003 | β |
| Stem cells in normal breast development and breast cancer. | Dontu G et al. | β | 2003 | β |
| Radial glial cells as neuronal precursors: the next generation? | Gregg CT et al. | β | 2002 | β |