Evidence of sex-modulated association of ZNF804A with schizophrenia.
- Authors
- Zhang, Fengyu; Chen, Qiang; Ye, Tianzhang; Lipska, Barbara K; Straub, Richard E; Vakkalanka, Radhakrishna; Rujescu, Dan; St Clair, David; Hyde, Thomas M; Bigelow, Llewellyn; Kleinman, Joel E; Weinberger, Daniel R
- Year
- 2011
- Journal
- Biological psychiatry
- PMID
- 21349497
- DOI
- 10.1016/j.biopsych.2011.01.003
BACKGROUND: The single nucleotide polymorphism (SNP) rs1344706 in ZNF804A (2q32.1) has been associated with schizophrenia in a genome-wide association study (GWAS). A recent candidate gene study, which replicated the positive association with rs1344706, identified another positive SNP (rs7597593) in ZNF804A associated with schizophrenia. METHODS: We performed an association study of rs7597593 in four GWAS cohorts of European ancestry. Postmortem human brain expression data of normal Caucasian individuals (n = 89) was also analyzed for examining the effect of rs7597593 on ZNF804A messenger RNA expression, using logistic regression and linear regression. RESULTS: We found that rs7597593 was significantly associated with schizophrenia in the combined GWAS datasets (n = 5023, odds ratio [OR](combined) = 1.15, p = .0011). Analysis of stratification by sex showed that the association was driven by the female subjects (OR = 1.29, p = .0002) and was not significant in male subjects (OR = 1.08, p = .148) in the combined sample of four cohorts. A sex by genotype interaction was near significant in both the Genetic Association Information Network sample (p = .0532) and the combined sample of four cohorts (p(combined) = .0531). Gene expression analysis showed no main effects but a significant female-specific association (p(female) = .047, p(male) = .335) and sex by genotype interaction (p = .0166) for rs7597593. CONCLUSIONS: Our data suggest a clinical and molecular modulation by sex of the association of ZNF804A SNP rs7597593 and risk of schizophrenia.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons | Sichlinger L et al. | — | 2024 | — |
| Spatial Dynamic Subspaces Encode Sex-Specific Schizophrenia Disruptions in Transient Network Overlap and Their Links to Genetic Risk. | Iraji A et al. | — | 2024 | → |
| Altered metabolic-functional coupling in the epileptogenic network could predict surgical outcomes of mesial temporal lobe epilepsy. | Yuan S et al. | — | 2023 | → |
| An association study of the HSPA8 gene polymorphisms with schizophrenia in a Polish population. | Kowalczyk M et al. | — | 2022 | → |
| Association between rs1344706 Polymorphism in the ZNF804A Gene and the Risk for Schizophrenia. | Esmaeili A et al. | — | 2021 | → |
| rs1344706 polymorphism of zinc finger protein 804a (ZNF804a) gene related to the integrity of white matter fiber bundle in schizophrenics. | Zhou J et al. | — | 2021 | → |
| Sex-Specific Associations of <i>MIR137</i> Polymorphisms With Schizophrenia in a Han Chinese Cohort. | Yin J et al. | — | 2021 | → |
| ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors. | Huang Y et al. | — | 2021 | → |
| Association of HSPA1B Polymorphisms with Paranoid Schizophrenia in a Polish Population. | Kowalczyk M et al. | — | 2020 | → |
| A schizophrenia associated CMYA5 allele displays differential binding with desmin. | Hsiung A et al. | — | 2019 | → |
| Data on association of the variation (rs1344706) in the ZNF804A gene with schizophrenia and its symptoms in the Russian population. | Lezheiko TV et al. | — | 2019 | → |
| Association Studies of HSPA1A and HSPA1L Gene Polymorphisms With Schizophrenia. | Kowalczyk M et al. | — | 2018 | → |
| Common variation in ZNF804A (rs1344706) is not associated with brain morphometry in schizophrenia or healthy participants. | Quidé Y et al. | — | 2018 | → |
| Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment. | Zhou Y et al. | — | 2018 | → |
| The genome-wide associated candidate gene ZNF804A and psychosis-proneness: Evidence of sex-modulated association. | de Castro-Catala M et al. | — | 2017 | → |
| The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions. | Chang H et al. | — | 2017 | → |
| The schizophrenia susceptibility gene ZNF804A confers risk of major mood disorders. | Ou J et al. | — | 2017 | → |
| A comprehensive meta-analysis of ZNF804A SNPs in the risk of schizophrenia among Asian populations. | Huang L et al. | — | 2016 | → |
| Childhood trauma, BDNF Val66Met and subclinical psychotic experiences. Attempt at replication in two independent samples. | de Castro-Catala M et al. | — | 2016 | → |
| No association between ZNF804A rs1344706 and schizophrenia in a case-control study of Han Chinese. | Wang J et al. | — | 2016 | → |
| ZNF804A variants confer risk for heroin addiction and affect decision making and gray matter volume in heroin abusers. | Sun Y et al. | — | 2016 | → |
| Association between variants of zinc finger genes and psychiatric disorders: systematic review and meta-analysis. | Sun Y et al. | — | 2015 | → |
| Replication of ZNF804A gene variant associations with risk of heroin addiction. | Hancock DB et al. | — | 2015 | → |
| Allelic variants in the zinc transporter-3 gene, SLC30A3, a candidate gene identified from gene expression studies, show gender-specific association with schizophrenia. | Perez-Becerril C et al. | — | 2014 | → |
| Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex. | Guella I et al. | — | 2014 | → |
| Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706. | Tao R et al. | — | 2014 | → |
| Heat shock protein 70 gene polymorphisms are associated with paranoid schizophrenia in the Polish population. | Kowalczyk M et al. | — | 2014 | → |
| How might ZNF804A variants influence risk for schizophrenia and bipolar disorder? A literature review, synthesis, and bioinformatic analysis. | Hess JL et al. | — | 2014 | → |
| Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia. | Schwab SG et al. | — | 2013 | → |
| Genetics of psychiatric disorders in the GWAS era: an update on schizophrenia. | Schwab SG et al. | — | 2013 | → |
| Implications of sex-specific selection for the genetic basis of disease. | Morrow EH et al. | — | 2013 | → |
| Meta-analysis indicates that the European GWAS-identified risk SNP rs1344706 within ZNF804A is not associated with schizophrenia in Han Chinese population. | Li M et al. | — | 2013 | → |
| Sex differences in the genetic risk for schizophrenia: history of the evidence for sex-specific and sex-dependent effects. | Goldstein JM et al. | — | 2013 | → |
| Variation in psychosis gene ZNF804A is associated with a refined schizotypy phenotype but not neurocognitive performance in a large young male population. | Stefanis NC et al. | — | 2013 | → |
| A polymerase chain reaction-restriction fragment length polymorphism method for screening ZNF804A gene polymorphism (rs1344706) in patients with schizophrenia: a significant association. | Sazci A et al. | — | 2012 | → |
| Evidence that schizophrenia risk variation in the ZNF804A gene exerts its effects during fetal brain development. | Hill MJ et al. | — | 2012 | → |
| Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706. | Zhang R et al. | — | 2012 | → |
| Genetic evidence for the association between the early growth response 3 (EGR3) gene and schizophrenia. | Zhang R et al. | — | 2012 | → |
| Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia. | Wassink TH et al. | — | 2012 | → |
| ZNF804A and schizophrenia susceptibility in Asian populations. | Li M et al. | — | 2012 | → |
| ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2. | Girgenti MJ et al. | — | 2012 | → |
| ZNF804A rs1344706 variant and schizophrenia in a Romanian population from Cluj Napoca. | Zaharie A et al. | — | 2012 | → |
| Allelic differences between Han Chinese and Europeans for functional variants in ZNF804A and their association with schizophrenia. | Li M et al. | — | 2011 | → |
| Functional themes from psychiatric genome-wide screens. | Davies W | — | 2011 | → |
| Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis. | Zhang R et al. | — | 2011 | → |
| [Systematic review of the Genomewide Association Studies (GWAS) in schizophrenia]. | Valiente A et al. | — | 2011 | → |