Mpdz is a quantitative trait gene for drug withdrawal seizures.
paper
Cited
Public
Unavailable
- Authors
- Shirley, Renee L; Walter, Nicole A R; Reilly, Matthew T; Fehr, Christoph; Buck, Kari J
- Year
- 2004
- Journal
- Nature neuroscience
- PMID
- 15208631
- DOI
- 10.1038/nn1271
Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.
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