Self-regulation of human brain activity using simultaneous real-time fMRI and EEG neurofeedback.
paper
Cited
Public
Unavailable
- Authors
- Zotev, Vadim; Phillips, Raquel; Yuan, Han; Misaki, Masaya; Bodurka, Jerzy
- Year
- 2014
- Journal
- NeuroImage
- PMID
- 23668969
- DOI
- 10.1016/j.neuroimage.2013.04.126
Neurofeedback is a promising approach for non-invasive modulation of human brain activity with applications for treatment of mental disorders and enhancement of brain performance. Neurofeedback techniques are commonly based on either electroencephalography (EEG) or real-time functional magnetic resonance imaging (rtfMRI). Advances in simultaneous EEG-fMRI have made it possible to combine the two approaches. Here we report the first implementation of simultaneous multimodal rtfMRI and EEG neurofeedback (rtfMRI-EEG-nf). It is based on a novel system for real-time integration of simultaneous rtfMRI and EEG data streams. We applied the rtfMRI-EEG-nf to training of emotional self-regulation in healthy subjects performing a positive emotion induction task based on retrieval of happy autobiographical memories. The participants were able to simultaneously regulate their BOLD fMRI activation in the left amygdala and frontal EEG power asymmetry in the high-beta band using the rtfMRI-EEG-nf. Our proof-of-concept results demonstrate the feasibility of simultaneous self-regulation of both hemodynamic (rtfMRI) and electrophysiological (EEG) activities of the human brain. They suggest potential applications of rtfMRI-EEG-nf in the development of novel cognitive neuroscience research paradigms and enhanced cognitive therapeutic approaches for major neuropsychiatric disorders, particularly depression.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| A genome wide association study of fast beta EEG in families of European ancestry. | 2017 | 28040410 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Attachment Style, Task Difficulty, and Feedback Type: Effects on Cognitive Load. | Mizrahi D et al. | — | 2025 | → |
| Digital emotional regulation paradox: a cross-sectional study on mindful technology use moderates the relationship between social media emotional content exposure and psychological resilience. | Sandra L | — | 2025 | → |
| Effects of technology-enhanced physical activity on brain and mental health in youth: An umbrella review of meta-analyses. | Wang ZQ et al. | — | 2025 | → |
| Evaluating the effects of multimodal EEG-fNIRS neurofeedback for motor imagery: An experimental platform and study protocol. | Muller CO et al. | — | 2025 | → |
| Evaluation of Theta EEG Neurofeedback Procedure for Cognitive Training Using Simultaneous fMRI in Counterbalanced Active-Sham Study Design. | Zotev V et al. | — | 2025 | → |
| Improved performance of fNIRS-BCI by stacking of deep learning-derived frequency domain features. | Akhter J et al. | — | 2025 | → |
| Leveraging Simultaneous EEG-fMRI for Functional Connectivity Biomarker Estimation in Schizophrenia: Insights from EEG Neurofeedback Training in Healthy Individuals | Tamano R et al. | — | 2025 | — |
| New Insights in the Treatment of Substance Use Disorders Thanks to Electrophysiological Tools. | Campanella S et al. | — | 2025 | → |
| Real-Time Attention Regulation and Cognitive Monitoring Using a Wearable EEG-Based BCI. | Huang H et al. | — | 2025 | → |
| Could neurofeedback improve therapist-patient communication? Considering the potential for neuroscience informed examinations of the psychotherapeutic relationship. | Morrissey G et al. | — | 2024 | → |
| Neurofeedback for alcohol addiction: Changes in resting state network activity<sup>✰</sup>. | Sanader Vukadinovic B et al. | — | 2024 | → |
| QEEG Characterizations During Hyperventilation, Writing and Reading Conditions: A Pre-Post Cognitive-Behavioral Intervention Study on Students with Learning Difficulty. | Kaushik P | — | 2024 | → |
| Validation of real-time fMRI neurofeedback procedure for cognitive training using counterbalanced active-sham study design. | Zotev V et al. | — | 2024 | → |
| EEG-LLAMAS: A low-latency neurofeedback platform for artifact reduction in EEG-fMRI. | Levitt J et al. | — | 2023 | → |
| Embodied strategies for public speaking anxiety: evaluation of the Corp-Oral program. | García-Monge A et al. | — | 2023 | → |
| Neural and behavioral adaptations to frontal theta neurofeedback training: A proof of concept study. | Kerick SE et al. | — | 2023 | → |
| Neural modulation enhancement using connectivity-based EEG neurofeedback with simultaneous fMRI for emotion regulation. | Dehghani A et al. | — | 2023 | → |
| No evidence from a negative mood induction fMRI task for frontal functional asymmetry as a suitable neurofeedback target. | Zhang J et al. | — | 2023 | → |
| Self-blame in major depression: a randomised pilot trial comparing fMRI neurofeedback with self-guided psychological strategies. | Jaeckle T et al. | — | 2023 | → |
| Simultaneous real-time EEG-fMRI neurofeedback: A systematic review. | Ciccarelli G et al. | — | 2023 | → |
| The Impact of Complementary and Integrative Medicine Following Traumatic Brain Injury: A Scoping Review. | Kim S et al. | — | 2023 | → |
| Two is better? combining EEG and fMRI for BCI and neurofeedback: a systematic review. | Fleury M et al. | — | 2023 | → |
| Canonical EEG microstates transitions reflect switching among BOLD resting state networks and predict fMRI signal. | Al Zoubi O et al. | — | 2022 | → |
| Changes in EEG Activity Following Live <i>Z</i>-Score Training Predict Changes in Persistent Post-concussive Symptoms: An Exploratory Analysis. | Hershaw JN et al. | — | 2022 | → |
| Dynamic functional connectivity estimation for neurofeedback emotion regulation paradigm with simultaneous EEG-fMRI analysis. | Mosayebi R et al. | — | 2022 | → |
| Emotion Self-Regulation in Neurotic Students: A Pilot Mindfulness-Based Intervention to Assess Its Effectiveness through Brain Signals and Behavioral Data. | Izhar LI et al. | — | 2022 | → |
| Interactions between emotions and eating behaviors: Main issues, neuroimaging contributions, and innovative preventive or corrective strategies. | Godet A et al. | — | 2022 | → |
| Neurofeedback-Augmented Mindfulness Training Elicits Distinct Responses in the Subregions of the Insular Cortex in Healthy Adolescents. | Yu X et al. | — | 2022 | → |
| Probing fMRI brain connectivity and activity changes during emotion regulation by EEG neurofeedback. | Dehghani A et al. | — | 2022 | → |
| Self-regulation of the posterior cingulate cortex with real-time fMRI neurofeedback augmented mindfulness training in healthy adolescents: A nonrandomized feasibility study. | Kirlic N et al. | — | 2022 | → |
| Simultaneous EEG-fMRI: What Have We Learned and What Does the Future Hold? | Warbrick T | — | 2022 | → |
| Simultaneous electroencephalography-functional magnetic resonance imaging for assessment of human brain function. | Ebrahimzadeh E et al. | — | 2022 | → |
| Affective Neurofeedback Under Naturalistic Conditions: A Mini-Review of Current Achievements and Open Challenges. | Trambaiolli LR et al. | — | 2021 | → |
| A Novel Cognition-Guided Neurofeedback BCI Dataset on Nicotine Addiction. | Bu J et al. | — | 2021 | → |
| Automated pipeline for EEG artifact reduction (APPEAR) recorded during fMRI. | Mayeli A et al. | — | 2021 | → |
| Inferring Macroscale Brain Dynamics via Fusion of Simultaneous EEG-fMRI. | Philiastides MG et al. | — | 2021 | → |
| Recent findings on neurofeedback training for auditory hallucinations in schizophrenia. | Hirano Y et al. | — | 2021 | → |
| Reinforcement of Self-Regulated Brain Activity in Schizophrenia Patients Undergoing Rehabilitation. | Markiewicz R et al. | — | 2021 | → |
| The Current Evidence Levels for Biofeedback and Neurofeedback Interventions in Treating Depression: A Narrative Review. | Melnikov MY | — | 2021 | → |
| The impact of neurofeedback on effective connectivity networks in chronic stroke patients: an exploratory study. | Giulia L et al. | — | 2021 | → |
| A Guide to Literature Informed Decisions in the Design of Real Time fMRI Neurofeedback Studies: A Systematic Review. | Fede SJ et al. | — | 2020 | → |
| A Multi-Target Motor Imagery Training Using Bimodal EEG-fMRI Neurofeedback: A Pilot Study in Chronic Stroke Patients. | Lioi G et al. | — | 2020 | → |
| Brain-computer interfaces in neurologic rehabilitation practice. | Pichiorri F et al. | — | 2020 | → |
| Design and Characterization of an EEG-Hat for Reliable EEG Measurements. | Kawana T et al. | — | 2020 | → |
| Effects of simultaneous real-time fMRI and EEG neurofeedback in major depressive disorder evaluated with brain electromagnetic tomography. | Zotev V et al. | — | 2020 | → |
| Emotion self-regulation training in major depressive disorder using simultaneous real-time fMRI and EEG neurofeedback. | Zotev V et al. | — | 2020 | → |
| Global Data-Driven Analysis of Brain Connectivity During Emotion Regulation by Electroencephalography Neurofeedback. | Dehghani A et al. | — | 2020 | → |
| How much of the BOLD-fMRI signal can be approximated from simultaneous EEG data: relevance for the transfer and dissemination of neurofeedback interventions. | Simões M et al. | — | 2020 | → |
| Preventing relapse in alcohol disorder with EEG-neurofeedback as a neuromodulation technique: A review and new insights regarding its application. | Dousset C et al. | — | 2020 | → |
| Real-Time Functional Magnetic Resonance Imaging Neurofeedback for the Relief of Distressing Auditory-Verbal Hallucinations: Methodological and Empirical Advances. | Humpston C et al. | — | 2020 | → |
| Self-regulation of ventromedial prefrontal cortex activation using real-time fMRI neurofeedback-Influence of default mode network. | Mayeli A et al. | — | 2020 | → |
| Simultaneous EEG-fMRI during a neurofeedback task, a brain imaging dataset for multimodal data integration. | Lioi G et al. | — | 2020 | → |
| The Influence of Physiological and Psychological Learning Mechanisms in Neurofeedback vs. Mental Imagery Against Binge Eating. | Schmidt J et al. | — | 2020 | → |
| The learning effects and curves during high beta down-training neurofeedback for patients with major depressive disorder. | Chen TC et al. | — | 2020 | → |
| The role of the subgenual anterior cingulate cortex in dorsomedial prefrontal-amygdala neural circuitry during positive-social emotion regulation. | Scharnowski F et al. | — | 2020 | → |
| Amygdala Modulation During Emotion Regulation Training With fMRI-Based Neurofeedback. | Barreiros AR et al. | — | 2019 | → |
| A Sparse EEG-Informed fMRI Model for Hybrid EEG-fMRI Neurofeedback Prediction. | Cury C et al. | — | 2019 | → |
| A systematic review of the psychological factors that influence neurofeedback learning outcomes. | Kadosh KC et al. | — | 2019 | → |
| Deep neural network predicts emotional responses of the human brain from functional magnetic resonance imaging. | Kim HC et al. | — | 2019 | → |
| EEG neurofeedback research: A fertile ground for psychiatry? | Batail JM et al. | — | 2019 | → |
| fMRI neurofeedback in emotion regulation: A literature review. | Linhartová P et al. | — | 2019 | → |
| Simultaneous EEG-fMRI for Functional Neurological Assessment. | Mele G et al. | — | 2019 | → |
| Targeting dynamic facial processing mechanisms in superior temporal sulcus using a novel fMRI neurofeedback target. | Direito B et al. | — | 2019 | → |
| The effects of alpha asymmetry and high-beta down-training neurofeedback for patients with the major depressive disorder and anxiety symptoms. | Wang SY et al. | — | 2019 | → |
| Two-stage regression of high-density scalp electroencephalograms visualizes force regulation signaling during muscle contraction. | Hayashi M et al. | — | 2019 | → |
| A Motivational Model of BCI-Controlled Heuristic Search. | Cavazza M | — | 2018 | → |
| Clustering-Constrained ICA for Ballistocardiogram Artifacts Removal in Simultaneous EEG-fMRI. | Wang K et al. | — | 2018 | → |
| Neurofeedback with fMRI: A critical systematic review. | Thibault RT et al. | — | 2018 | → |
| Online Reduction of Artifacts in EEG of Simultaneous EEG-fMRI Using Reference Layer Adaptive Filtering (RLAF). | Steyrl D et al. | — | 2018 | → |
| Real-time fMRI neurofeedback of the mediodorsal and anterior thalamus enhances correlation between thalamic BOLD activity and alpha EEG rhythm. | Zotev V et al. | — | 2018 | → |
| Real-time fMRI neurofeedback training of the amygdala activity with simultaneous EEG in veterans with combat-related PTSD. | Zotev V et al. | — | 2018 | → |
| Resting-state functional connectivity remains unaffected by preceding exposure to aversive visual stimuli. | Geissmann L et al. | — | 2018 | → |
| Tracking resting state connectivity dynamics in veterans with PTSD. | Yuan H et al. | — | 2018 | → |
| A genome wide association study of fast beta EEG in families of European ancestry. | Meyers JL et al. | — | 2017 | → |
| Analytical Techniques in Neuroscience: Recent Advances in Imaging, Separation, and Electrochemical Methods. | Ganesana M et al. | — | 2017 | → |
| A New Generation of Brain-Computer Interfaces Driven by Discovery of Latent EEG-fMRI Linkages Using Tensor Decomposition. | Deshpande G et al. | — | 2017 | → |
| A unified canonical correlation analysis-based framework for removing gradient artifact in concurrent EEG/fMRI recording and motion artifact in walking recording from EEG signal. | Li J et al. | — | 2017 | → |
| BCI Control of Heuristic Search Algorithms. | Cavazza M et al. | — | 2017 | → |
| Closed-loop brain training: the science of neurofeedback. | Sitaram R et al. | — | 2017 | → |
| Direct modulation of aberrant brain network connectivity through real-time NeuroFeedback. | Ramot M et al. | — | 2017 | → |
| Distributed Patterns of Brain Activity Underlying Real-Time fMRI Neurofeedback Training. | Kopel R et al. | — | 2017 | → |
| Feedback of real-time fMRI signals: From concepts and principles to therapeutic interventions. | Sokunbi MO | — | 2017 | → |
| How to Build a Hybrid Neurofeedback Platform Combining EEG and fMRI. | Mano M et al. | — | 2017 | → |
| Neurofeedback learning modifies the incidence rate of alpha spindles, but not their duration and amplitude. | Ossadtchi A et al. | — | 2017 | → |
| OpenNFT: An open-source Python/Matlab framework for real-time fMRI neurofeedback training based on activity, connectivity and multivariate pattern analysis. | Koush Y et al. | — | 2017 | → |
| The neurobiology of emotion regulation in posttraumatic stress disorder: Amygdala downregulation via real-time fMRI neurofeedback. | Nicholson AA et al. | — | 2017 | → |
| Tuning Up the Old Brain with New Tricks: Attention Training via Neurofeedback. | Jiang Y et al. | — | 2017 | → |
| Unimodal Versus Bimodal EEG-fMRI Neurofeedback of a Motor Imagery Task. | Perronnet L et al. | — | 2017 | → |
| Variable slice thickness (VAST) EPI for the reduction of susceptibility artifacts in whole-brain GE-EPI at 7 Tesla. | Brunheim S et al. | — | 2017 | → |
| Activation of sensory cortex by imagined genital stimulation: an fMRI analysis. | Wise NJ et al. | — | 2016 | → |
| Affective Interaction with a Virtual Character Through an fNIRS Brain-Computer Interface. | Aranyi G et al. | — | 2016 | → |
| Amygdala Regulation Following fMRI-Neurofeedback without Instructed Strategies. | Marxen M et al. | — | 2016 | → |
| A real-time method to reduce ballistocardiogram artifacts from EEG during fMRI based on optimal basis sets (OBS). | Wu X et al. | — | 2016 | → |
| Ballistocardiogram artifact correction taking into account physiological signal preservation in simultaneous EEG-fMRI. | Abreu R et al. | — | 2016 | → |
| Carbon-wire loop based artifact correction outperforms post-processing EEG/fMRI corrections--A validation of a real-time simultaneous EEG/fMRI correction method. | van der Meer JN et al. | — | 2016 | → |
| Correlation between amygdala BOLD activity and frontal EEG asymmetry during real-time fMRI neurofeedback training in patients with depression. | Zotev V et al. | — | 2016 | → |
| Data-Driven User Feedback: An Improved Neurofeedback Strategy considering the Interindividual Variability of EEG Features. | Han CH et al. | — | 2016 | → |
| Neurofeedback training for major depressive disorder: recent developments and future directions. | Sacchet MD et al. | — | 2016 | → |
| One-Class FMRI-Inspired EEG Model for Self-Regulation Training. | Meir-Hasson Y et al. | — | 2016 | → |
| Real-time EEG artifact correction during fMRI using ICA. | Mayeli A et al. | — | 2016 | → |
| Real-time functional magnetic resonance imaging neurofeedback in motor neurorehabilitation. | Linden DE et al. | — | 2016 | → |
| Short and long-term effects of sham-controlled prefrontal EEG-neurofeedback training in healthy subjects. | Engelbregt HJ et al. | — | 2016 | → |
| The neural correlates of happiness: A review of PET and fMRI studies using autobiographical recall methods. | Suardi A et al. | — | 2016 | → |
| The self-regulating brain and neurofeedback: Experimental science and clinical promise. | Thibault RT et al. | — | 2016 | → |
| A proof-of-principle study of multi-site real-time functional imaging at 3T and 7T: Implementation and validation. | Baecke S et al. | — | 2015 | → |
| Decoding the Traumatic Memory among Women with PTSD: Implications for Neurocircuitry Models of PTSD and Real-Time fMRI Neurofeedback. | Cisler JM et al. | — | 2015 | → |
| Feature analysis for correlation studies of simultaneous EEG-fMRI data: A proof of concept for neurofeedback approaches. | Simoes S et al. | — | 2015 | → |
| Neurofeedback, Self-Regulation, and Brain Imaging: Clinical Science and Fad in the Service of Mental Disorders. | Thibault RT et al. | — | 2015 | → |
| Pulse artifact detection in simultaneous EEG-fMRI recording based on EEG map topography. | Iannotti GR et al. | — | 2015 | → |
| Real-time EEG feedback during simultaneous EEG-fMRI identifies the cortical signature of motor imagery. | Zich C et al. | — | 2015 | → |
| Recursive approach of EEG-segment-based principal component analysis substantially reduces cryogenic pump artifacts in simultaneous EEG-fMRI data. | Kim HC et al. | — | 2015 | → |
| Restoring large-scale brain networks in PTSD and related disorders: a proposal for neuroscientifically-informed treatment interventions. | Lanius RA et al. | — | 2015 | → |
| Synergetic fMRI-EEG brain mapping in alpha-rhythm voluntary control mode. | Shtark MB et al. | — | 2015 | → |
| The Promise of Neurotechnology in Clinical Translational Science. | White SW et al. | — | 2015 | → |
| EEG-neurofeedback for optimising performance. III: a review of methodological and theoretical considerations. | Gruzelier JH | — | 2014 | → |
| Optimizing real time fMRI neurofeedback for therapeutic discovery and development. | Stoeckel LE et al. | — | 2014 | → |
| Voluntary modulation of anterior cingulate response to negative feedback. | Shane MS et al. | — | 2014 | → |
| Prefrontal control of the amygdala during real-time fMRI neurofeedback training of emotion regulation. | Zotev V et al. | — | 2013 | → |