Expression of mammalian gamma-aminobutyric acid receptors with distinct pharmacology in Xenopus oocytes.
paper
Cited
Public
Unavailable
- Authors
- Polenzani, L; Woodward, R M; Miledi, R
- Year
- 1991
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 1709741
- DOI
- 10.1073/pnas.88.10.4318
- PMCID
- PMC51650
Gamma-Aminobutyric acid (GABA), the major inhibitory neurotransmitter in mammalian brain, is known to interact with two classes of GABA receptors denoted GABAA and GABAB. Using Xenopus oocytes, we compared the electrical and pharmacological properties of GABA receptors expressed by poly(A)+ RNA isolated from mammalian brain and retina. RNA from cerebral cortex expressed GABA responses with features characteristic of currents mediated by GABAA receptors. In contrast, RNA from retina expressed responses mediated by GABAA receptors and, in addition, GABA responses that were insensitive to the GABAA antagonist bicuculline and the GABAB agonist baclofen and showed no modulation by barbiturates or benzodiazepines. The bicuculline/baclofen-insensitive GABA response was a Cl- current that was blocked by picrotoxin but showed little desensitization or outward rectification. Our results suggest that mammalian retina contains RNAs encoding GABA receptors with distinct pharmacology.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. | 2010 | 19536785 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| From Neurotransmission to Retinal Pathophysiology: Unraveling the Role of GABA Receptors in Retinal Disease Progression. | Medina Arellano AE et al. | β | 2025 | β |
| GABA mitigates mitochondrial apoptosis induced by high temperature stress in the Pacific oyster (Crassostrea gigas). | Liu R et al. | β | 2025 | β |
| Re-Evaluation of the Ultrastructural Localization of Tonic GABA-A Receptors. | Rosas-Arellano A | β | 2025 | β |
| The Regulation of Ξ³-Aminobutyric Acid on Antioxidative Defense Response of Pacific Oyster upon High-Temperature Stress. | Liu R et al. | β | 2025 | β |
| Structure and dynamics of differential ligand binding in the human Ο-type GABA<sub>A</sub> receptor. | Cowgill J et al. | β | 2023 | β |
| Action of the Photochrome Glyght on GABAergic Synaptic Transmission in Mouse Brain Slices. | Petukhova E et al. | β | 2022 | β |
| Antiseizure medication in early nervous system development. Ion channels and synaptic proteins as principal targets. | Castro PA et al. | β | 2022 | β |
| GABA<sub>B</sub> Receptor Chemistry and Pharmacology: Agonists, Antagonists, and Allosteric Modulators. | Nieto A et al. | β | 2022 | β |
| Activation of GABA(A) receptors inhibits T cell proliferation. | Sparrow EL et al. | β | 2021 | β |
| Rational approaches for the design of various GABA modulators and their clinical progression. | Bhagat K et al. | β | 2021 | β |
| Ξ-Aminobutyric acid in adult brain: an update. | Siucinska E | β | 2019 | β |
| Differential modulation of human GABA<sub>C</sub>-Ο1 receptor by sulfur-containing compounds structurally related to taurine. | Ochoa-de la Paz LD et al. | β | 2018 | β |
| Huntington's disease leads to decrease of GABA-A tonic subunits in the D2 neostriatal pathway and their relocalization into the synaptic cleft. | Rosas-Arellano A et al. | β | 2018 | β |
| Negative modulation of the GABA<sub>A</sub> Ο1 receptor function by l-cysteine. | BeltrΓ‘n GonzΓ‘lez AN et al. | β | 2018 | β |
| The adjustment of Ξ³-aminobutyric acid<sub>A</sub> tonic subunits in Huntington's disease: from transcription to translation to synaptic levels into the neostriatum. | Rosas-Arellano A et al. | β | 2018 | β |
| Antagonistic effect of dopamine structural analogues on human GABAΟ1 receptor. | Alaniz-Palacios A et al. | β | 2017 | β |
| GABA-Ο receptors: distinctive functions and molecular pharmacology. | Naffaa MM et al. | β | 2017 | β |
| GABAΟ selective antagonist TPMPA partially inhibits GABA-mediated currents recorded from neurones and astrocytes in mouse striatum. | Reyes-Haro D et al. | β | 2017 | β |
| Differential effects of quercetin glycosides on GABAC receptor channel activity. | Kim HJ et al. | β | 2015 | β |
| Benzodiazepine modulation of homomeric GABAAΟ1 receptors: differential effects of diazepam and 4'-chlorodiazepam. | BeltrΓ‘n GonzΓ‘lez AN et al. | β | 2014 | β |
| Cloning and characterization of the ionotropic GABA receptor subunit Ο1 from pig (Sus scrofa). | Reyes-Ruiz JM et al. | β | 2014 | β |
| GABAΟ subunits confer a bicuculline-insensitive component to GFAP+ cells of cerebellum. | PΓ©triz A et al. | β | 2014 | β |
| Characterization of GABA receptors. | Enna SJ et al. | β | 2013 | β |
| Identification of the minimal promoter for specific expression of the GABAΟ1 receptor in retinal bipolar cells. | Machuca-Parra AI et al. | β | 2013 | β |
| Quantum dot conjugates of GABA and muscimol: binding to Ξ±1Ξ²2Ξ³2 and Ο1 GABA(A) receptors. | Gussin HA et al. | β | 2013 | β |
| Dopamine and serotonin modulate human GABAΟ1 receptors expressed in Xenopus laevis oocytes. | Ochoa-de la Paz LD et al. | β | 2012 | β |
| Expression of GABAΟ receptors in the neostriatum: localization in aspiny, medium spiny neurons and GFAP-positive cells. | Rosas-Arellano A et al. | β | 2012 | β |
| Nematode cys-loop GABA receptors: biological function, pharmacology and sites of action for anthelmintics. | Accardi MV et al. | β | 2012 | β |
| An historical perspective on GABAergic drugs. | Froestl W | β | 2011 | β |
| Dynamics of GABAΟ2 receptors in retinal bipolar neurons and cerebellar astrocytes. | MartΓnez-Delgado G et al. | β | 2011 | β |
| Medicinal chemistry of Ο GABAC receptors. | Ng CK et al. | β | 2011 | β |
| Neurovascular interaction and the pathophysiology of diabetic retinopathy. | Qian H et al. | β | 2011 | β |
| Subunit-specific polyclonal antibody targeting human Ο1 GABA(C) receptor. | Gussin HA et al. | β | 2011 | β |
| The GABA(A)Ο receptors in hippocampal spontaneous activity and their distribution in hippocampus, amygdala and visual cortex. | Rosas-Arellano A et al. | β | 2011 | β |
| An Update on GABAΟ Receptors. | MartΓnez-Delgado G et al. | β | 2010 | β |
| Functional impact of serial deletions at the C-terminus of the human GABArho1 receptor. | Reyes-Ruiz JM et al. | β | 2010 | β |
| GABA(A) Ο receptor mechanisms in the rat amygdala and its role in the modulation of fear and anxiety. | Flores-Gracia C et al. | β | 2010 | β |
| GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. | Xuei X et al. | β | 2010 | β |
| Neurochemicals for the investigation of GABA(C) receptors. | Johnston GA et al. | β | 2010 | β |
| Structure-function study of the fourth transmembrane segment of the GABAΟ1 receptor. | Estrada-MondragΓ³n A et al. | β | 2010 | β |
| An autonomous circadian clock in the inner mouse retina regulated by dopamine and GABA. | Ruan GX et al. | β | 2008 | β |
| Expression of GABArho subunits during rat cerebellum development. | MejΓa C et al. | β | 2008 | β |
| Modulation of human GABArho1 receptors by taurine. | Ochoa-de la Paz LD et al. | β | 2008 | β |
| Brain distribution and molecular cloning of the bovine GABA rho1 receptor. | Rosas-Arellano A et al. | β | 2007 | β |
| Colocalization of synaptic GABA(C)-receptors with GABA (A)-receptors and glycine-receptors in the rodent central nervous system. | Frazao R et al. | β | 2007 | β |
| Emerging roles for ubiquitin and protein degradation in neuronal function. | Yi JJ et al. | β | 2007 | β |
| Ambient GABA promotes cortical entry of tangentially migrating cells derived from the medial ganglionic eminence. | Cuzon VC et al. | β | 2006 | β |
| Design, synthesis, and biological evaluation of a scaffold for iGluR ligands based on the structure of (-)-dysiherbaine. | Cohen JL et al. | β | 2006 | β |
| Activation of membrane receptors by a neurotransmitter conjugate designed for surface attachment. | Vu TQ et al. | β | 2005 | β |
| Analysis of macroscopic ionic currents mediated by GABArho1 receptors during lanthanide modulation predicts novel states controlling channel gating. | Goutman JD et al. | β | 2005 | β |
| Cloning and functional expression of the bovine GABA(C) rho2 subunit. Molecular evidence of a widespread distribution in the CNS. | LΓ³pez-ChΓ‘vez A et al. | β | 2005 | β |
| Interactions between rho and gamma2 subunits of the GABA receptor. | Pan Y et al. | β | 2005 | β |
| A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism. | MartΓnez-Torres A et al. | β | 2004 | β |
| Characterization of receptors for glutamate and GABA in retinal neurons. | Yang XL | β | 2004 | β |
| Electrophysiological properties of mouse horizontal cell GABAA receptors. | Feigenspan A et al. | β | 2004 | β |
| Evidence for inhibition mediated by coassembly of GABAA and GABAC receptor subunits in native central neurons. | Milligan CJ et al. | β | 2004 | β |
| Expression of functional receptors by the human gamma-aminobutyric acid A gamma 2 subunit. | MartΓnez-Torres A et al. | β | 2004 | β |
| Functional expression in frog oocytes of human rho 1 receptors produced in Saccharomyces cerevisiae. | MartΓnez-MartΓnez A et al. | β | 2004 | β |
| Ionotropic GABA receptors with mixed pharmacological properties of GABAA and GABAC receptors. | Hartmann K et al. | β | 2004 | β |
| Pharmacological and biochemical aspects of GABAergic neurotransmission: pathological and neuropsychobiological relationships. | Beleboni RO et al. | β | 2004 | β |
| Postsynaptic localization of gamma-aminobutyric acid transporters and receptors in the outer plexiform layer of the goldfish retina: An ultrastructural study. | Klooster J et al. | β | 2004 | β |
| Studies on the mechanisms of action of picrotoxin, quercetin and pregnanolone at the GABA rho 1 receptor. | Goutman JD et al. | β | 2004 | β |
| Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord. | Zheng W et al. | β | 2003 | β |
| Molecular and physiological evidence for functional gamma-aminobutyric acid (GABA)-C receptors in growth hormone-secreting cells. | Gamel-Didelon K et al. | β | 2003 | β |
| Expression of human epileptic temporal lobe neurotransmitter receptors in Xenopus oocytes: An innovative approach to study epilepsy. | Palma E et al. | β | 2002 | β |
| gamma-Aminobutyric acidA rho receptor subunits in the developing rat hippocampus. | Didelon F et al. | β | 2002 | β |
| Molecular structure and physiological function of chloride channels. | Jentsch TJ et al. | β | 2002 | β |
| Expression of gamma-aminobutyric acid rho 1 and rho 1 Delta 450 as gene fusions with the green fluorescent protein. | Martinez-Torres A et al. | β | 2001 | β |
| GABA(C) receptors: a molecular view. | Enz R | β | 2001 | β |
| Recombinant GABA(C) receptors expressed in rat hippocampal neurons after infection with an adenovirus containing the human rho1 subunit. | Filippova N et al. | β | 2001 | β |
| Structure and function of GABA(C) receptors: a comparison of native versus recombinant receptors. | Zhang D et al. | β | 2001 | β |
| Evidence for coassembly of mutant GABAC rho1 with GABAA gamma2S, glycine alpha1 and glycine alpha2 receptor subunits in vitro. | Pan ZH et al. | β | 2000 | β |
| Expression of GABA(C) receptor rho1 and rho2 subunits during development of the mouse retina. | Greka A et al. | β | 2000 | β |
| Functional and pharmacological properties of GABArho1delta51 receptors. | Demuro A et al. | β | 2000 | β |
| GABArho 1/GABAAalpha 1 receptor chimeras to study receptor desensitization. | MartΓnez-Torres A et al. | β | 2000 | β |
| The 'ABC' of GABA receptors. | Bormann J | β | 2000 | β |
| Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine. | Chang Y et al. | β | 1999 | β |
| Antagonistic action of pitrazepin on human and rat GABA(A) receptors. | Demuro A et al. | β | 1999 | β |
| A single amino acid in the second transmembrane domain of GABA rho subunits is a determinant of the response kinetics of GABAC receptors. | Qian H et al. | β | 1999 | β |
| Bicuculline-resistant, Cl- dependent GABA response in the rat spinal dorsal horn. | Park JS et al. | β | 1999 | β |
| Dopamine receptor subtypes modulate olfactory bulb gamma-aminobutyric acid type A receptors. | BrΓΌnig I et al. | β | 1999 | β |
| Effects of the conformationally restricted GABA analogues, cis- and trans-4-aminocrotonic acid, on GABA neurotransmission in primary neuronal cultures. | Vale C et al. | β | 1999 | β |
| Evidence for phosphorylation-dependent internalization of recombinant human rho1 GABAC receptors. | Filippova N et al. | β | 1999 | β |
| GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala. | Delaney AJ et al. | β | 1999 | β |
| Ion channels in presynaptic nerve terminals and control of transmitter release. | Meir A et al. | β | 1999 | β |
| Permeability and single channel conductance of human homomeric rho1 GABAC receptors. | Wotring VE et al. | β | 1999 | β |
| Role of GABAA and GABAC receptors in the biphasic GABA responses in neurons of the rat major pelvic ganglia. | Akasu T et al. | β | 1999 | β |
| Suppression of sustained and transient ON signals of amacrine cells by GABA is mediated by different receptor subtypes. | Zhang D et al. | β | 1999 | β |
| The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses. | Hanley JG et al. | β | 1999 | β |
| Cloning and characterization of mouse GABA(C) receptor subunits. | Greka A et al. | β | 1998 | β |
| Cloning and functional expression of alternative spliced variants of the rho1 gamma-aminobutyrate receptor. | MartΓnez-Torres A et al. | β | 1998 | β |
| Distribution of GABA receptor rho subunit transcripts in the rat brain. | Wegelius K et al. | β | 1998 | β |
| GABAA and GABAC receptors in adult porcine cones: evidence from a photoreceptor-glia co-culture model. | Picaud S et al. | β | 1998 | β |
| GABAA and GABAC receptors on mammalian rod bipolar cells. | Fletcher EL et al. | β | 1998 | β |
| Glycine and GABA receptors in the mammalian retina. | WΓ€ssle H et al. | β | 1998 | β |
| Molecular composition of GABAC receptors. | Enz R et al. | β | 1998 | β |
| mRNAs coding for neurotransmitter receptors and voltage-gated sodium channels in the adult rabbit visual cortex after monocular deafferentiation. | Nguyen QT et al. | β | 1998 | β |
| Two distinct nicotinic receptors, one pharmacologically similar to the vertebrate alpha7-containing receptor, mediate Cl currents in aplysia neurons. | Kehoe J et al. | β | 1998 | β |
| Adenovirus vector-mediated gene transfer into human epileptogenic brain slices: prospects for gene therapy in epilepsy. | O'Connor WM et al. | β | 1997 | β |
| Desensitizing GABAC receptors on carp retinal bipolar cells. | Han MH et al. | β | 1997 | β |
| GABAC receptors on ferret retinal bipolar cells: a diversity of subtypes in mammals? | Lukasiewicz PD et al. | β | 1997 | β |
| Immunocytochemical localization of the GABA(C) receptor rho subunits in the cat, goldfish, and chicken retina. | Koulen P et al. | β | 1997 | β |
| Inhibitory effects of corymine, an alkaloidal component from the leaves of Hunteria zeylanica, on glycine receptors expressed in Xenopus oocytes. | Leewanich P et al. | β | 1997 | β |
| Locomotor-related presynaptic modulation of primary afferents in the lamprey. | El Manira A et al. | β | 1997 | β |
| The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction. | Hackam AS et al. | β | 1997 | β |
| Two types of identified ascending interneurons with distinct GABA receptors in the crayfish terminal abdominal ganglion. | Miyata H et al. | β | 1997 | β |
| Agonist pharmacology of two Drosophila GABA receptor splice variants. | Hosie AM et al. | β | 1996 | β |
| Allosteric modulation of an expressed homo-oligomeric GABA-gated chloride channel of Drosophila melanogaster. | Hosie AM et al. | β | 1996 | β |
| GABAC receptors in the vertebrate retina. | Lukasiewicz PD | β | 1996 | β |
| Glutamate responses of bipolar cells in a slice preparation of the rat retina. | Euler T et al. | β | 1996 | β |
| Immunocytochemical localization of the GABAc receptor rho subunits in the mammalian retina. | Enz R et al. | β | 1996 | β |
| Synaptic organization of an organotypic slice culture of the mammalian retina. | SassoΓ¨-Pognetto M et al. | β | 1996 | β |
| Activation of GABA rho 1 receptors by glycine and beta-alanine. | Calvo DJ et al. | β | 1995 | β |
| A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibition. | Wang TL et al. | β | 1995 | β |
| Cloning of a gamma-aminobutyric acid type C receptor subunit in rat retina with a methionine residue critical for picrotoxinin channel block. | Zhang D et al. | β | 1995 | β |
| Expression of GABA receptor rho 1 and rho 2 subunits in the retina and brain of the rat. | Enz R et al. | β | 1995 | β |
| From ion currents to genomic analysis: recent advances in GABAA receptor research. | Rabow LE et al. | β | 1995 | β |
| Modulatory actions of gamma aminobutyric acid (GABA) on GABA type A receptor subunit expression and function. | Schousboe A et al. | β | 1995 | β |
| Structure and pharmacology of vertebrate GABAA receptor subtypes. | Whiting PJ et al. | β | 1995 | β |
| Cationic modulation of rho 1-type gamma-aminobutyrate receptors expressed in Xenopus oocytes. | Calvo DJ et al. | β | 1994 | β |
| Facilitation of GABAergic signaling in the retina by receptors stimulating adenylate cyclase. | Feigenspan A et al. | β | 1994 | β |
| Modulation of GABAC receptors in rat retinal bipolar cells by protein kinase C. | Feigenspan A et al. | β | 1994 | β |
| Rand Lecture, ASCEPT. GABA receptors: as complex as ABC? Australaisian Society for Clinical and Experimental Pharmacologists and Toxicologists. | Johnston GA | β | 1994 | β |
| Regulation of endogenous dopamine release in amphibian retina by gamma-aminobutyric acid and glycine. | Boatright JH et al. | β | 1994 | β |
| Transient expression of a novel type of GABA response in rat CA3 hippocampal neurones during development. | Strata F et al. | β | 1994 | β |
| Expression of neurotransmitter receptors by mRNAs from neurons developing in vitro: a Xenopus oocyte expression study. | Wahl P et al. | β | 1993 | β |
| mRNAs coding for neurotransmitter receptors in rabbit and rat visual areas. | Matute C et al. | β | 1993 | β |
| Novel GABA responses from rod-driven retinal horizontal cells. | Qian H et al. | β | 1993 | β |
| Pharmacology of GABA receptor Cl- channels in rat retinal bipolar cells. | Feigenspan A et al. | β | 1993 | β |
| Pharmacology of GABA rho 1 and GABA alpha/beta receptors expressed in Xenopus oocytes and COS cells. | Kusama T et al. | β | 1993 | β |
| Bicuculline- and baclofen-insensitive gamma-aminobutyric acid binding to rat cerebellar membranes. | Drew CA et al. | β | 1992 | β |
| GABA agonists and antagonists. | Kerr DI et al. | β | 1992 | β |
| Immunoreactivity to GABAA receptor in the outer plexiform layer of the cat retina. | Vardi N et al. | β | 1992 | β |