A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.
paper
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- Authors
- Cho, Michael H; Castaldi, Peter J; Wan, Emily S; Siedlinski, Mateusz; Hersh, Craig P; Demeo, Dawn L; Himes, Blanca E; Sylvia, Jody S; Klanderman, Barbara J; Ziniti, John P; Lange, Christoph; Litonjua, Augusto A; Sparrow, David; Regan, Elizabeth A; Make, Barry J; Hokanson, John E; Murray, Tanda; Hetmanski, Jacqueline B; Pillai, Sreekumar G; Kong, Xiangyang; Anderson, Wayne H; Tal-Singer, Ruth; Lomas, David A; Coxson, Harvey O; Edwards, Lisa D; MacNee, William; Vestbo, JΓΈrgen; Yates, Julie C; Agusti, Alvar; Calverley, Peter M A; Celli, Bartolome; Crim, Courtney; Rennard, Stephen; Wouters, Emiel; Bakke, Per; Gulsvik, Amund; Crapo, James D; Beaty, Terri H; Silverman, Edwin K; ICGN Investigators; ECLIPSE Investigators; COPDGene Investigators
- Year
- 2012
- Journal
- Human molecular genetics
- PMID
- 22080838
- DOI
- 10.1093/hmg/ddr524
- PMCID
- PMC3298111
The genetic risk factors for chronic obstructive pulmonary disease (COPD) are still largely unknown. To date, genome-wide association studies (GWASs) of limited size have identified several novel risk loci for COPD at CHRNA3/CHRNA5/IREB2, HHIP and FAM13A; additional loci may be identified through larger studies. We performed a GWAS using a total of 3499 cases and 1922 control subjects from four cohorts: the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE); the Normative Aging Study (NAS) and National Emphysema Treatment Trial (NETT); Bergen, Norway (GenKOLS); and the COPDGene study. Genotyping was performed on Illumina platforms with additional markers imputed using 1000 Genomes data; results were summarized using fixed-effect meta-analysis. We identified a new genome-wide significant locus on chromosome 19q13 (rs7937, OR = 0.74, P = 2.9 Γ 10(-9)). Genotyping this single nucleotide polymorphism (SNP) and another nearby SNP in linkage disequilibrium (rs2604894) in 2859 subjects from the family-based International COPD Genetics Network study (ICGN) demonstrated supportive evidence for association for COPD (P = 0.28 and 0.11 for rs7937 and rs2604894), pre-bronchodilator FEV(1) (P = 0.08 and 0.04) and severe (GOLD 3&4) COPD (P = 0.09 and 0.017). This region includes RAB4B, EGLN2, MIA and CYP2A6, and has previously been identified in association with cigarette smoking behavior.
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| Whole genome sequence analysis of pulmonary function and COPD in 44,287 multi-ancestry participants. | Kim W et al. | β | 2026 | β |
| Clinical Characteristics of Chronic Obstructive Pulmonary Disease according to Smoking Status. | Park JH | β | 2025 | β |
| From COPD to Smoke-Related Arteriopathy: The Mechanical and Immune-Inflammatory Landscape Underlying Lung Cancer Distant Spreading-A Narrative Review. | Stella GM et al. | β | 2025 | β |
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| SNAI2, a potential crossing point between cancer and cardiovascular disease. | Liu Z et al. | β | 2025 | β |
| A cross-tissue transcriptome-wide association study reveals GRK4 as a novel susceptibility gene for COPD. | Chen G et al. | β | 2024 | β |
| Clarifying Chronic Obstructive Pulmonary Disease Genetic Associations Observed in Biobanks via Mediation Analysis of Smoking. | Bazemore K et al. | β | 2024 | β |
| Colocalization analysis of 3' UTR alternative polyadenylation quantitative trait loci reveals novel mechanisms underlying associations with lung function. | Saferali A et al. | β | 2024 | β |
| CYP2A6 associates with respiratory disease risk and younger age of diagnosis: a phenome-wide association Mendelian Randomization study. | Giratallah H et al. | β | 2024 | β |
| Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function. | Seo J et al. | β | 2024 | β |
| Biological and Genetic Mechanisms of COPD, Its Diagnosis, Treatment, and Relationship with Lung Cancer. | Czarnecka-Chrebelska KH et al. | β | 2023 | β |
| Chronic Obstructive Pulmonary Disease: Novel Genes Detection with Penalized Logistic Regression. | Gohari K et al. | β | 2023 | β |
| Effect of PRDX6 gene polymorphism on susceptibility to chronic obstructive pulmonary disease in the Chinese Han population. | Xiong M et al. | β | 2023 | β |
| Hierarchical association of COPD to principal genetic components of biological systems. | Carlin DE et al. | β | 2023 | β |
| Assessing the contribution of rare genetic variants to phenotypes of chronic obstructive pulmonary disease using whole-genome sequence data. | Kim W et al. | β | 2022 | β |
| Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision. | Celli B et al. | β | 2022 | β |
| GAWMerge expands GWAS sample size and diversity by combining array-based genotyping and whole-genome sequencing. | Mathur R et al. | β | 2022 | β |
| Genetic Variants Associated with Chronic Obstructive Pulmonary Disease Risk: Cumulative Epidemiological Evidence from Meta-Analyses and Genome-Wide Association Studies. | Liu C et al. | β | 2022 | β |
| Incorporating Biomarkers in COPD Management: The Research Keeps Going. | Pantazopoulos I et al. | β | 2022 | β |
| Mechanisms of Lung Damage and Development of COPD Due to Household Biomass-Smoke Exposure: Inflammation, Oxidative Stress, MicroRNAs, and Gene Polymorphisms. | Ortiz-Quintero B et al. | β | 2022 | β |
| Chronic Obstructive Pulmonary Disease: Epidemiology, Biomarkers, and Paving the Way to Lung Cancer. | Szalontai K et al. | β | 2021 | β |
| Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease. | Lakshman Kumar P et al. | β | 2021 | β |
| Genome-wide association study of letrozole plasma concentrations identifies non-exonic variants that may affect CYP2A6 metabolic activity. | Hertz DL et al. | β | 2021 | β |
| Genome-Wide Gene-by-Smoking Interaction Study of Chronic Obstructive Pulmonary Disease. | Kim W et al. | β | 2021 | β |
| HLA-C and KIR permutations influence chronic obstructive pulmonary disease risk. | Mkorombindo T et al. | β | 2021 | β |
| Tempo-spatial regulation of the Wnt pathway by FAM13A modulates the stemness of alveolar epithelial progenitors. | Lin X et al. | β | 2021 | β |
| The AGE-RAGE Axis and RAGE Genetics in Chronic Obstructive Pulmonary Disease. | Sharma A et al. | β | 2021 | β |
| Transferability of Ancestry-Specific and Cross-Ancestry CYP2A6 Activity Genetic Risk Scores in African and European Populations. | El-Boraie A et al. | β | 2021 | β |
| A Between Ethnicities Comparison of Chronic Obstructive Pulmonary Disease Genetic Risk. | Gim J et al. | β | 2020 | β |
| Comparison and development of machine learning tools for the prediction of chronic obstructive pulmonary disease in the Chinese population. | Ma X et al. | β | 2020 | β |
| Different Associations Between the <i>IREB2</i> Variants and Chronic Obstructive Pulmonary Disease Susceptibility. | Zeng Q et al. | β | 2020 | β |
| DNA Methylation in Chronic Obstructive Pulmonary Disease. | Chen X et al. | β | 2020 | β |
| Epithelial cell-specific loss of function of <i>Miz1</i> causes a spontaneous COPD-like phenotype and up-regulates <i>Ace2</i> expression in mice. | Do-Umehara HC et al. | β | 2020 | β |
| Evaluation of a weighted genetic risk score for the prediction of biomarkers of CYP2A6 activity. | El-Boraie A et al. | β | 2020 | β |
| Genetic regulation of gene expression of MIF family members in lung tissue. | Florez-Sampedro L et al. | β | 2020 | β |
| Identification of biomarkers associated with clinical severity of chronic obstructive pulmonary disease. | Zhang J et al. | β | 2020 | β |
| Microarray analysis identifies defects in regenerative and immune response pathways in COPD airway basal cells. | Pineau F et al. | β | 2020 | β |
| Plasma Metabolomic Signatures of Chronic Obstructive Pulmonary Disease and the Impact of Genetic Variants on Phenotype-Driven Modules. | Gillenwater LA et al. | β | 2020 | β |
| Prenatal smoke exposure induces persistent <i>Cyp2a5</i> methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring. | Lkhagvadorj K et al. | β | 2020 | β |
| Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants. | Zhao X et al. | β | 2020 | β |
| Airway morphology and inspiratory flow features in the early stages of Chronic Obstructive Pulmonary Disease. | Van de Moortele T et al. | β | 2019 | β |
| Analysis of genetically driven alternative splicing identifies FBXO38 as a novel COPD susceptibility gene. | Saferali A et al. | β | 2019 | β |
| Correlations of an Insertion/Deletion Polymorphism (rs10680577) in the RERT-lncRNA with the Susceptibility, Clinicopathological Features, and Prognosis of Lung Cancer. | Zhu J et al. | β | 2019 | β |
| DSP variants may be associated with longitudinal change in quantitative emphysema. | Kim W et al. | β | 2019 | β |
| Exploring the cross-phenotype network region of disease modules reveals concordant and discordant pathways between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. | Halu A et al. | β | 2019 | β |
| Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. | Ragland MF et al. | β | 2019 | β |
| Genetic risk factors for the development of pulmonary disease identified by genome-wide association. | Hall R et al. | β | 2019 | β |
| Genetic underpinnings of lung function and COPD. | Ranjan A et al. | β | 2019 | β |
| Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population. | van der Plaat DA et al. | β | 2019 | β |
| Low miR-150-5p and miR-320b Expression Predicts Reduced Survival of COPD Patients. | Keller A et al. | β | 2019 | β |
| New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. | Shrine N et al. | β | 2019 | β |
| Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes. | Bloom AJ et al. | β | 2019 | β |
| RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD. | Morrow JD et al. | β | 2019 | β |
| A novel method to test associations between a weighted combination of phenotypes and genetic variants. | Zhu H et al. | β | 2018 | β |
| Association between Genetic Variations of MERTK and Chronic Obstructive Pulmonary Disease in Koreans. | Kim WJ et al. | β | 2018 | β |
| Association of Time to First Morning Cigarette and Chronic Obstructive Pulmonary Disease Measured by Spirometry in Current Smokers. | Kim G et al. | β | 2018 | β |
| COPD GWAS variant at 19q13.2 in relation with DNA methylation and gene expression. | Nedeljkovic I et al. | β | 2018 | β |
| COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix. | Willis-Owen SAG et al. | β | 2018 | β |
| Dissecting respiratory disease heterogeneity through the genetics of diffusing capacity. | Hobbs BD et al. | β | 2018 | β |
| Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease. | Morrow JD et al. | β | 2018 | β |
| Extracellular matrix in lung development, homeostasis and disease. | Zhou Y et al. | β | 2018 | β |
| Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development. | Keller A et al. | β | 2018 | β |
| Genotype imputation performance of three reference panels using African ancestry individuals. | Vergara C et al. | β | 2018 | β |
| Hypoxia Signaling in Vascular Homeostasis. | Marsboom G et al. | β | 2018 | β |
| Integration of Molecular Interactome and Targeted Interaction Analysis to Identify a COPD Disease Network Module. | Sharma A et al. | β | 2018 | β |
| Integrative genomics identifies new genes associated with severe COPD and emphysema. | Sakornsakolpat P et al. | β | 2018 | β |
| Leveraging lung tissue transcriptome to uncover candidate causal genes in COPD genetic associations. | Lamontagne M et al. | β | 2018 | β |
| Matrix metalloproteinases in emphysema. | Gharib SA et al. | β | 2018 | β |
| New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries | Shrine N et al. | β | 2018 | β |
| Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. | Teitelbaum AM et al. | β | 2018 | β |
| The PHD1 oxygen sensor in health and disease. | Kennel KB et al. | β | 2018 | β |
| Whole-Genome Sequencing in Severe Chronic Obstructive Pulmonary Disease. | Prokopenko D et al. | β | 2018 | β |
| Alpha-1 Antitrypsin PiMZ Genotype Is Associated with Chronic Obstructive Pulmonary Disease in Two Racial Groups. | Foreman MG et al. | β | 2017 | β |
| Association of multiple genetic variants with chronic obstructive pulmonary disease susceptibility in Hainan region. | Ding Y et al. | β | 2017 | β |
| Association of nsv823469 copy number loss with decreased risk of chronic obstructive pulmonary disease and pulmonary function in Chinese. | Chen X et al. | β | 2017 | β |
| Chronic Obstructive Pulmonary Disease Meta Genome-Wide Association Studies. New Insights into the Genetics of Chronic Obstructive Pulmonary Disease. | Rajput C | β | 2017 | β |
| Epigenome-wide association study of chronic obstructive pulmonary disease and lung function in Koreans. | Lee MK et al. | β | 2017 | β |
| Extreme Trait Whole-Genome Sequencing Identifies PTPRO as a Novel Candidate Gene in Emphysema with Severe Airflow Obstruction. | Radder JE et al. | β | 2017 | β |
| Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. | Morrow JD et al. | β | 2017 | β |
| Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects. | Busch R et al. | β | 2017 | β |
| Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. | Hobbs BD et al. | β | 2017 | β |
| Genetic Pleiotropy between Nicotine Dependence and Respiratory Outcomes. | Zhang J et al. | β | 2017 | β |
| Genetic polymorphism of heme oxygenase 1 promoter in the occurrence and severity of chronic obstructive pulmonary disease: a meta-analysis. | Zhou H et al. | β | 2017 | β |
| Genetic studies as a tool for identifying novel potential targets for treatment ofΒ COPD. | Manichaikul A et al. | β | 2017 | β |
| Integrative Genomics of Emphysema-Associated Genes: Are We Closer to Identifying the Genetic Determinants of Lung Function? | Sharma S | β | 2017 | β |
| Phenotyping Before Starting Treatment in COPD? | Siafakas N et al. | β | 2017 | β |
| Screening for interaction effects in gene expression data. | Castaldi PJ et al. | β | 2017 | β |
| Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. | Hardin M et al. | β | 2017 | β |
| Smoking status and gene susceptibility play important roles in the development of chronic obstructive pulmonary disease and lung function decline: A population-based prospective study. | Zhao J et al. | β | 2017 | β |
| Vascular transcriptome profiling identifies Sphingosine kinase 1 as a modulator of angiotensin II-induced vascular dysfunction. | Siedlinski M et al. | β | 2017 | β |
| What do polymorphisms tell us about the mechanisms of COPD? | Li Y et al. | β | 2017 | β |
| A genome-wide analysis of the response to inhaled Ξ²2-agonists in chronic obstructive pulmonary disease. | Hardin M et al. | β | 2016 | β |
| Complex genetics of pulmonary diseases: lessons from genome-wide association studies and next-generation sequencing. | Pouladi N et al. | β | 2016 | β |
| Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations. | Busch R et al. | β | 2016 | β |
| DNA methylation profiling in human lung tissue identifies genes associated with COPD. | Morrow JD et al. | β | 2016 | β |
| Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. | Hobbs BD et al. | β | 2016 | β |
| Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. | Qiao D et al. | β | 2016 | β |
| Hemizygous Deletion on Chromosome 3p26.1 Is Associated with Heavy Smoking among African American Subjects in the COPDGene Study. | Begum F et al. | β | 2016 | β |
| Identifying a Deletion Affecting Total Lung Capacity Among Subjects in the COPDGene Study Cohort. | Begum F et al. | β | 2016 | β |
| Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. | Cloonan SM et al. | β | 2016 | β |
| Post-GWAS Prioritization Through Data Integration Provides Novel Insights on Chronic Obstructive Pulmonary Disease. | Lu Q et al. | β | 2016 | β |
| The role of WWOX polymorphisms on COPD susceptibility and pulmonary function traits in Chinese: a case-control study and family-based analysis. | Xie C et al. | β | 2016 | β |
| Time to First Cigarette, a Proxy of Nicotine Dependence, Increases the Risk of Pulmonary Impairment, Independently of Current and Lifetime Smoking Behavior. | Selya AS et al. | β | 2016 | β |
| Translating Lung Function Genome-Wide Association Study (GWAS) Findings: New Insights for Lung Biology. | Kheirallah AK et al. | β | 2016 | β |
| Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility. | Bruse S et al. | β | 2016 | β |
| A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. | Lutz SM et al. | β | 2015 | β |
| A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. | Cho MH et al. | β | 2015 | β |
| A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. | Hancock DB et al. | β | 2015 | β |
| Candidate genes for COPD: current evidence and research. | Kim WJ et al. | β | 2015 | β |
| Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD. | Dijkstra AE et al. | β | 2015 | β |
| Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. | Castaldi PJ et al. | β | 2015 | β |
| Genetic variation in HTR4 and lung function: GWAS follow-up in mouse. | House JS et al. | β | 2015 | β |
| Heritability of pulmonary function estimated from genome-wide SNPs in healthy Japanese adults. | Yamada H et al. | β | 2015 | β |
| Identification of FAM13A gene associated with the ratio of FEV1 to FVC in Korean population by genome-wide association studies including gene-environment interactions. | Kim S et al. | β | 2015 | β |
| Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD. | Yoo S et al. | β | 2015 | β |
| IREB2 and GALC are associated with pulmonary artery enlargement in chronic obstructive pulmonary disease. | Lee JH et al. | β | 2015 | β |
| Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. | Soler Artigas M et al. | β | 2015 | β |
| The Functional Copy Number Variation-67048 in WWOX Contributes to Increased Risk of COPD in Southern and Eastern Chinese. | Yang L et al. | β | 2015 | β |
| Variants in multiple genes polymorphism association analysis of COPD in the Chinese Li population. | Ding Y et al. | β | 2015 | β |
| Airway basal cells. The "smoking gun" of chronic obstructive pulmonary disease. | Crystal RG | β | 2014 | β |
| Beyond GWAS in COPD: probing the landscape between gene-set associations, genome-wide associations and protein-protein interaction networks. | McDonald ML et al. | β | 2014 | β |
| Chronic Obstructive Pulmonary Disease Genetics: A Review of the Past and a Look Into the Future. | Hardin M et al. | β | 2014 | β |
| Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema. | Castaldi PJ et al. | β | 2014 | β |
| Common genetic variants associated with resting oxygenation in chronic obstructive pulmonary disease. | McDonald ML et al. | β | 2014 | β |
| Disease risk factors identified through shared genetic architecture and electronic medical records. | Li L et al. | β | 2014 | β |
| DNAH5 is associated with total lung capacity in chronic obstructive pulmonary disease. | Lee JH et al. | β | 2014 | β |
| DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways. | Vucic EA et al. | β | 2014 | β |
| Early events in the pathogenesis of chronic obstructive pulmonary disease. Smoking-induced reprogramming of airway epithelial basal progenitor cells. | Shaykhiev R et al. | β | 2014 | β |
| Effects of a functional variant c.353T>C in snai1 on risk of two contextual diseases. Chronic obstructive pulmonary disease and lung cancer. | Yang L et al. | β | 2014 | β |
| Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction. | Lamontagne M et al. | β | 2014 | β |
| Genetic susceptibility. | Marciniak SJ et al. | β | 2014 | β |
| Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. | Lee JH et al. | β | 2014 | β |
| Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. | Castaldi PJ et al. | β | 2014 | β |
| Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. | Manichaikul A et al. | β | 2014 | β |
| Integrative genomics of chronic obstructive pulmonary disease. | Hobbs BD et al. | β | 2014 | β |
| Lessons from ECLIPSE: a review of COPD biomarkers. | Faner R et al. | β | 2014 | β |
| On the simultaneous association analysis of large genomic regions: a massive multi-locus association test. | Qiao D et al. | β | 2014 | β |
| Personalized medicine for chronic, complex diseases: chronic obstructive pulmonary disease as an example. | Radder JE et al. | β | 2014 | β |
| Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. | Lee JH et al. | β | 2014 | β |
| Predictors of chronic obstructive pulmonary disease exacerbations. | Ishii T et al. | β | 2014 | β |
| Protection genes in nucleus accumbens shell affect vulnerability to nicotine self-administration across isogenic strains of adolescent rat. | Chen H et al. | β | 2014 | β |
| Reprogramming of COPD lung fibroblasts through formation of induced pluripotent stem cells. | Basma H et al. | β | 2014 | β |
| Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. | Cho MH et al. | β | 2014 | β |
| Smoking dysregulates the human airway basal cell transcriptome at COPD risk locus 19q13.2. | Ryan DM et al. | β | 2014 | β |
| Susceptibility to chronic mucus hypersecretion, a genome wide association study. | Dijkstra AE et al. | β | 2014 | β |
| The IRP/IRE system in vivo: insights from mouse models. | Wilkinson N et al. | β | 2014 | β |
| Using pulmonary imaging to move chronic obstructive pulmonary disease beyond FEV1. | Coxson HO et al. | β | 2014 | β |
| Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms. | Bloom AJ et al. | β | 2014 | β |
| Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era. | Brothers JF et al. | β | 2013 | β |
| Chronic obstructive pulmonary disease. | Vijayan VK | β | 2013 | β |
| Chronic Obstructive Pulmonary Disease: official diagnosis and treatment guidelines of the Czech Pneumological and Phthisiological Society; a novel phenotypic approach to COPD with patient-oriented care. | Koblizek V et al. | β | 2013 | β |
| Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. | Siedlinski M et al. | β | 2013 | β |
| Elevated serum iron is a potent biomarker for spirometric resistance to cigarette smoke among Japanese males: the Takahata study. | Shibata Y et al. | β | 2013 | β |
| Extracellular matrix remodeling genes polymorphisms and risk of chronic bronchitis and recurrent pneumonia in children. | Korytina GF et al. | β | 2013 | β |
| Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells. | Zhou X et al. | β | 2013 | β |
| Genetic polymorphisms and associated susceptibility to asthma. | March ME et al. | β | 2013 | β |
| Genetic susceptibility to lung cancer and co-morbidities. | Yang IA et al. | β | 2013 | β |
| Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers. | Zhou JJ et al. | β | 2013 | β |
| Integrative omics approach identifies interleukin-16 as a biomarker of emphysema. | Bowler RP et al. | β | 2013 | β |
| One thousand genomes imputation in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium aggressive prostate cancer genome-wide association study. | Machiela MJ et al. | β | 2013 | β |
| Phenotypes and disease characterization in chronic obstructive pulmonary disease. Toward the extinction of phenotypes? | AgustΓ A | β | 2013 | β |
| Phenotyping the heterogeneity of chronic obstructive pulmonary disease. | Barker BL et al. | β | 2013 | β |
| Refining susceptibility loci of chronic obstructive pulmonary disease with lung eqtls. | Lamontagne M et al. | β | 2013 | β |
| Relationship between plasma fibrinogen levels and pulmonary function in the japanese population: the Takahata study. | Shibata Y et al. | β | 2013 | β |
| Research Highlights: Highlights from the latest articles in chronic obstructive pulmonary disease genetics. | BossΓ© Y | β | 2013 | β |
| The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans. | Bloom AJ et al. | β | 2013 | β |
| The effects of Gamijinhae-tang on elastase/lipopolysaccharide-induced lung inflammation in an animal model of acute lung injury. | Sohn SH et al. | β | 2013 | β |
| An insertion/deletion polymorphism within RERT-lncRNA modulates hepatocellular carcinoma risk. | Zhu Z et al. | β | 2012 | β |
| An omics strategy for discovering pulmonary biomarkers potentially relevant to the evaluation of tobacco products. | Wang H et al. | β | 2012 | β |
| Emerging genetics of COPD. | Berndt A et al. | β | 2012 | β |
| Genetic association between human chitinases and lung function in COPD. | Aminuddin F et al. | β | 2012 | β |
| Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. | Kim DK et al. | β | 2012 | β |
| Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. | Wilk JB et al. | β | 2012 | β |
| Perspective: How can genetics help? | Silverman EK | β | 2012 | β |
| Role of mtDNA haplogroups in COPD susceptibility in a southwestern Han Chinese population. | Zheng S et al. | β | 2012 | β |
| SERPINA1 PiZ and PiS heterozygotes and lung function decline in the SAPALDIA cohort. | Thun GA et al. | β | 2012 | β |
| Updates on the COPD gene list. | BossΓ© Y | β | 2012 | β |