No association of CRH1 receptor polymorphism haplotypes, harm avoidance and other personality dimensions in alcohol dependence: results from the Munich gene bank project for alcoholism.
- Authors
- Soyka, M; Preuss, U W; Koller, G; Zill, P; Hesselbrock, V; Bondy, B
- Year
- 2004
- Journal
- Addiction biology
- PMID
- 15203442
- DOI
- 10.1080/13556210410001674121
Because corticotrophin-releasing hormone (CRH) plays a central role in stress regulation, the possible role of CRH1 polymorphism for anxiety-related personality variables such as harm avoidance possibly associated with alcoholism was studied. The research instruments used to phenotype patients were adopted partly from the US collaborative study of the genetics of alcoholism and include a number of personality inventories such as the temperament and character inventory (TCI). Based on the examination of 170 alcoholic subjects no association was found between CRH1 receptor haplotypes of four single nuclotid polymorphisms (SNPs) and low and high temperament traits of harm avoidance, novelty seeking and reward dependence. The possible implications of these findings are discussed.
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In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Personality as an intermediate phenotype for genetic dissection of alcohol use disorder. | Oreland L et al. | — | 2018 | → |
| The influence of genes on "positive valence systems" constructs: A systematic review. | Hess JL et al. | — | 2016 | → |
| Association between corticotropin-releasing hormone receptor 1 and 2 (CRHR1 and CRHR2) gene polymorphisms and personality traits. | Ishitobi Y et al. | — | 2013 | → |
| Behavioral Studies and Genetic Alterations in Corticotropin-Releasing Hormone (CRH) Neurocircuitry: Insights into Human Psychiatric Disorders. | Laryea G et al. | — | 2012 | → |
| Interacting effects of CRHR1 gene and stressful life events on drinking initiation and progression among 19-year-olds. | Schmid B et al. | — | 2010 | → |
| Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. | Chen AC et al. | — | 2010 | → |
| HPA-axis activity in alcoholism: examples for a gene-environment interaction. | Clarke TK et al. | — | 2008 | → |
| Interaction between CRHR1 gene and stressful life events predicts adolescent heavy alcohol use. | Blomeyer D et al. | — | 2008 | → |
| Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. | Treutlein J et al. | — | 2006 | → |