Genome-wide, large-scale production of mutant mice by ENU mutagenesis.
paper
Cited
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- Authors
- HrabΓ© de Angelis, M H; Flaswinkel, H; Fuchs, H; Rathkolb, B; Soewarto, D; Marschall, S; Heffner, S; Pargent, W; Wuensch, K; Jung, M; Reis, A; Richter, T; Alessandrini, F; Jakob, T; Fuchs, E; Kolb, H; Kremmer, E; Schaeble, K; Rollinski, B; Roscher, A; Peters, C; Meitinger, T; Strom, T; Steckler, T; Holsboer, F; Klopstock, T; Gekeler, F; Schindewolf, C; Jung, T; Avraham, K; Behrendt, H; Ring, J; Zimmer, A; Schughart, K; Pfeffer, K; Wolf, E; Balling, R
- Year
- 2000
- Journal
- Nature genetics
- PMID
- 10932192
- DOI
- 10.1038/78146
In the post-genome era, the mouse will have a major role as a model system for functional genome analysis. This requires a large number of mutants similar to the collections available from other model organisms such as Drosophila melanogaster and Caenorhabditis elegans. Here we report on a systematic, genome-wide, mutagenesis screen in mice. As part of the German Human Genome Project, we have undertaken a large-scale ENU-mutagenesis screen for dominant mutations and a limited screen for recessive mutations. In screening over 14,000 mice for a large number of clinically relevant parameters, we recovered 182 mouse mutants for a variety of phenotypes. In addition, 247 variant mouse mutants are currently in genetic confirmation testing and will result in additional new mutant lines. This mutagenesis screen, along with the screen described in the accompanying paper, leads to a significant increase in the number of mouse models available to the scientific community. Our mutant lines are freely accessible to non-commercial users (for information, see http://www.gsf.de/ieg/groups/enu-mouse.html).
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| A phenotype-driven ENU mutagenesis screen for the identification of dominant mutations involved in alcohol consumption. | Pawlak CR et al. | β | 2008 | β |
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| ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta. | Lisse TS et al. | β | 2008 | β |
| From ENU mutagenesis to population genetics. | Mitchison NA et al. | β | 2008 | β |
| Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. | Probst FJ et al. | β | 2008 | β |
| Insight into the genetics of diabetic nephropathy through the study of mice. | Breyer MD et al. | β | 2008 | β |
| Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis. | Jakob T et al. | β | 2008 | β |
| PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice. | Sun LV et al. | β | 2008 | β |
| Quiet as a mouse: dissecting the molecular and genetic basis of hearing. | Brown SD et al. | β | 2008 | β |
| Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects. | McGowan KA et al. | β | 2008 | β |
| Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance. | Goldsworthy M et al. | β | 2008 | β |
| Studies on <i>N</i>-Ethyl-<i>N</i>-nitrosourea Mutagenesis in BALB/c Mice. | Cho KH et al. | β | 2008 | β |
| Studies on the Small Body Size Mouse Developed by Mutagen <i>N</i>-Ethyl-<i>N</i>-nitrosourea. | Zhang Q et al. | β | 2008 | β |
| Systematic gene expression profiling of mouse model series reveals coexpressed genes. | Horsch M et al. | β | 2008 | β |
| The expanding role of mouse genetics for understanding human biology and disease. | Nguyen D et al. | β | 2008 | β |
| The novel mouse mutation Oblivion inactivates the PMCA2 pump and causes progressive hearing loss. | Spiden SL et al. | β | 2008 | β |
| The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells. | Loughran SJ et al. | β | 2008 | β |
| Trends in large-scale mouse mutagenesis: from genetics to functional genomics. | Gondo Y | β | 2008 | β |
| A Bcl-xL timer sets platelet life span. | Qi B et al. | β | 2007 | β |
| A forward genetics screen in mice identifies recessive deafness traits and reveals that pejvakin is essential for outer hair cell function. | Schwander M et al. | β | 2007 | β |
| A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse. | Rubio-Aliaga I et al. | β | 2007 | β |
| An IL-7 splicing-defect lymphopenia mouse model revealed by genome-wide mutagenesis. | Huang HW et al. | β | 2007 | β |
| Animal models of human disease: zebrafish swim into view. | Lieschke GJ et al. | β | 2007 | β |
| A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy. | Tchekneva EE et al. | β | 2007 | β |
| A series of ENU-induced single-base substitutions in a long-range cis-element altering Sonic hedgehog expression in the developing mouse limb bud. | Masuya H et al. | β | 2007 | β |
| Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease. | Oliver PL et al. | β | 2007 | β |
| Examining diabetic nephropathy through the lens of mouse genetics. | Breyer MD et al. | β | 2007 | β |
| Generation of ENU-induced mouse mutants with hypocholesterolemia: novel tools for dissecting plasma lipoprotein homeostasis. | Aigner B et al. | β | 2007 | β |
| Genetics of diabetic nephropathy: lessons from mice. | Breyer MD et al. | β | 2007 | β |
| Growth analysis of the mouse adrenal gland from weaning to adulthood: time- and gender-dependent alterations of cell size and number in the cortical compartment. | Bielohuby M et al. | β | 2007 | β |
| Identification of a Keratin 4 mutation in a chemically induced mouse mutant that models white sponge nevus. | McGowan KA et al. | β | 2007 | β |
| Impact of IVC housing on emotionality and fear learning in male C3HeB/FeJ and C57BL/6J mice. | Kallnik M et al. | β | 2007 | β |
| MR technology for biological studies in mice. | Nieman BJ et al. | β | 2007 | β |
| Phenosite: a web database integrating the mouse phenotyping platform and the experimental procedures in mice. | Masuya H et al. | β | 2007 | β |
| Power matters in closing the phenotyping gap. | Meyer CW et al. | β | 2007 | β |
| Probabilistic analysis of recessive mutagenesis screen strategies. | Silver JD et al. | β | 2007 | β |
| Production of cloned mice and ES cells from adult somatic cells by nuclear transfer: how to improve cloning efficiency? | Wakayama T | β | 2007 | β |
| Reaching and grasping phenotypes in the mouse (Mus musculus): a characterization of inbred strains and mutant lines. | Tucci V et al. | β | 2007 | β |
| Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models. | Aigner B et al. | β | 2007 | β |
| Spectrum of ENU-induced mutations in phenotype-driven and gene-driven screens in the mouse. | Barbaric I et al. | β | 2007 | β |
| The mouse as a model for human biology: a resource guide for complex trait analysis. | Peters LL et al. | β | 2007 | β |
| Whole organism approaches to chemical genomics: the promising role of zebrafish (Danio rerio). | Lan CC et al. | β | 2007 | β |
| A dynein mutation attenuates motor neuron degeneration in SOD1(G93A) mice. | Teuchert M et al. | β | 2006 | β |
| A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. | Nakayama M et al. | β | 2006 | β |
| A genetic screen for behavioral mutations that perturb dopaminergic homeostasis in mice. | Speca DJ et al. | β | 2006 | β |
| A mouse keratin 1 mutation causes dark skin and epidermolytic hyperkeratosis. | McGowan KA et al. | β | 2006 | β |
| Anatomical phenotyping in the brain and skull of a mutant mouse by magnetic resonance imaging and computed tomography. | Nieman BJ et al. | β | 2006 | β |
| Animal models of behavioral dysfunctions: basic concepts and classifications, and an evaluation strategy. | van der Staay FJ | β | 2006 | β |
| Approaches to lipid metabolism gene identification and characterization in the postgenomic era. | Reue K et al. | β | 2006 | β |
| Cloned mice and embryonic stem cell establishment from adult somatic cells. | Kishigami S et al. | β | 2006 | β |
| Engineering mutations: deconstructing the mouse gene by gene. | Raymond CS et al. | β | 2006 | β |
| ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein beta-subunit. | Kao HJ et al. | β | 2006 | β |
| ENU-mutagenesis: insight into immune function and pathology. | Cook MC et al. | β | 2006 | β |
| Establishment of nuclear transfer embryonic stem cell lines from adult somatic cells by nuclear transfer and its application. | Wakayama T | β | 2006 | β |
| Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens. | Keays DA et al. | β | 2006 | β |
| Evaluation of energy homeostasis. | Argmann CA et al. | β | 2006 | β |
| Genotype-specific environmental impact on the variance of blood values in inbred and F1 hybrid mice. | Klempt M et al. | β | 2006 | β |
| Identification of 17 hearing impaired mouse strains in the TMGC ENU-mutagenesis screen. | Kermany MH et al. | β | 2006 | β |
| Inducing mutations in the mouse genome with the chemical mutagen ethylnitrosourea. | Massironi SM et al. | β | 2006 | β |
| l7Rn6 encodes a novel protein required for clara cell function in mouse lung development. | FernΓ‘ndez-Valdivia R et al. | β | 2006 | β |
| Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice. | Vitaterna MH et al. | β | 2006 | β |
| Morphologic and molecular characterization of two novel Krt71 (Krt2-6g) mutations: Krt71rco12 and Krt71rco13. | Runkel F et al. | β | 2006 | β |
| Mouse models as a tool to unravel the genetic basis for human otitis media. | Zheng QY et al. | β | 2006 | β |
| Mutation at the Evi1 locus in Junbo mice causes susceptibility to otitis media. | Parkinson N et al. | β | 2006 | β |
| N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors. | Grosse J et al. | β | 2006 | β |
| N-ethyl-N-nitrosourea (ENU) mutagenesis and male fertility research. | Kennedy CL et al. | β | 2006 | β |
| New ENU-induced semidominant mutation, Ali18, causes inflammatory arthritis, dermatitis, and osteoporosis in the mouse. | Abe K et al. | β | 2006 | β |
| Risk assessment of mouse hepatitis virus infection via in vitro fertilization and embryo transfer by the use of zona-intact and laser-microdissected oocytes. | Peters DD et al. | β | 2006 | β |
| The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity. | Hoyne GF et al. | β | 2006 | β |
| Three-locus and four-locus QTL interactions influence mouse insulin-like growth factor-I. | Hanlon P et al. | β | 2006 | β |
| Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. | Alexander WS et al. | β | 2006 | β |
| Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea. | Marcotti W et al. | β | 2006 | β |
| Uncovering the uncharacterized and unexpected: unbiased phenotype-driven screens in the mouse. | Caspary T et al. | β | 2006 | β |
| Understanding mammalian genetic systems: the challenge of phenotyping in the mouse. | Brown SD et al. | β | 2006 | β |
| Analysis of human neurological disorders using mutagenesis in the mouse. | Oliver PL et al. | β | 2005 | β |
| ARTS: a web-based tool for the set-up of high-throughput genome-wide mapping panels for the SNP genotyping of mouse mutants. | Klaften M et al. | β | 2005 | β |
| Assessment of a systematic expression profiling approach in ENU-induced mouse mutant lines. | Seltmann M et al. | β | 2005 | β |
| Autoimmunity and inflammation due to a gain-of-function mutation in phospholipase C gamma 2 that specifically increases external Ca2+ entry. | Yu P et al. | β | 2005 | β |
| Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system. | Papathanasiou P et al. | β | 2005 | β |
| Diabetic nephropathy: of mice and men. | Breyer MD et al. | β | 2005 | β |
| Discovery genetics: serendipity in basic research. | Davisson MT | β | 2005 | β |
| Efficient and fast targeted production of murine models based on ENU mutagenesis. | Augustin M et al. | β | 2005 | β |
| Efficient gene-driven germ-line point mutagenesis of C57BL/6J mice. | Michaud EJ et al. | β | 2005 | β |
| EMPReSS: standardized phenotype screens for functional annotation of the mouse genome. | Brown SD et al. | β | 2005 | β |
| Fast spin-echo for multiple mouse magnetic resonance phenotyping. | Nieman BJ et al. | β | 2005 | β |
| From guts to brains: using zebrafish genetics to understand the innards of organogenesis. | Stuckenholz C et al. | β | 2005 | β |
| Hush puppy: a new mouse mutant with pinna, ossicle, and inner ear defects. | Pau H et al. | β | 2005 | β |
| Identification of a novel point mutation of mouse proto-oncogene c-kit through N-ethyl-N-nitrosourea mutagenesis. | Ruan HB et al. | β | 2005 | β |
| Identification of mutations from phenotype-driven ENU mutagenesis in mouse chromosome 7. | Culiat CT et al. | β | 2005 | β |
| Identifying novel genetic determinants of hemostatic balance. | Ginsburg D | β | 2005 | β |
| Impact of genomics on research in the rat. | Lazar J et al. | β | 2005 | β |
| Insertional mutagenesis in mice: new perspectives and tools. | Carlson CM et al. | β | 2005 | β |
| Introducing the German Mouse Clinic: open access platform for standardized phenotyping. | Gailus-Durner V et al. | β | 2005 | β |
| Lack of RNA-DNA oligonucleotide (chimeraplast) mutagenic activity in mouse embryos. | Tagalakis AD et al. | β | 2005 | β |
| Large-scale albuminuria screen for nephropathy models in chemically induced mouse mutants. | Rathkolb B et al. | β | 2005 | β |
| Large-scale genomic approaches to brain development and circuitry. | Hatten ME et al. | β | 2005 | β |
| Magnetic resonance imaging for detection and analysis of mouse phenotypes. | Nieman BJ et al. | β | 2005 | β |
| Mice with the enhanced green fluorescent protein gene knocked in to chromosome 11 exhibit normal transmission ratios. | Klysik J et al. | β | 2005 | β |
| Multiple mutations in mouse Chd7 provide models for CHARGE syndrome. | Bosman EA et al. | β | 2005 | β |
| Mutation of l7Rn3 shows that Odz4 is required for mouse gastrulation. | Lossie AC et al. | β | 2005 | β |
| N-ethyl-N-nitrosourea mutagenesis: boarding the mouse mutant express. | Cordes SP | β | 2005 | β |
| Phenotype-first screening for the identification of novel drug targets. | Austen M et al. | β | 2005 | β |
| Propagation of an infertile hermaphrodite mouse lacking germ cells by using nuclear transfer and embryonic stem cell technology. | Wakayama S et al. | β | 2005 | β |
| The art and design of genetic screens: mouse. | Kile BT et al. | β | 2005 | β |
| The mouse genome. | GuΓ©net JL | β | 2005 | β |
| The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line. | Kozlowski DJ et al. | β | 2005 | β |
| Two new mouse mutants with vestibular defects that map to the highly mutable locus on chromosome 4. | Hawker K et al. | β | 2005 | β |
| Use of bioinformatics tools for the annotation of disease-associated mutations in animal models. | Ferrer-Costa C et al. | β | 2005 | β |
| Using genomewide mutagenesis screens to identify the genes required for neural tube closure in the mouse. | Zohn IE et al. | β | 2005 | β |
| Zebrafish: a genetic model for hemostasis and thrombosis. | Jagadeeswaran P et al. | β | 2005 | β |
| A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. | Zarbalis K et al. | β | 2004 | β |
| A gene-driven ENU-based approach to generating an allelic series in any gene. | Quwailid MM et al. | β | 2004 | β |
| Amelogenesis imperfecta in a new animal model--a mutation in chromosome 5 (human 4q21). | Seedorf H et al. | β | 2004 | β |
| A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment. | Rhodes CR et al. | β | 2004 | β |
| An ENU-induced mutation in AP-2alpha leads to middle ear and ocular defects in Doarad mice. | Ahituv N et al. | β | 2004 | β |
| A new mouse model of type 2 diabetes, produced by N-ethyl-nitrosourea mutagenesis, is the result of a missense mutation in the glucokinase gene. | Toye AA et al. | β | 2004 | β |
| Annual fish as a genetic model for aging. | Herrera M et al. | β | 2004 | β |
| A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity. | Meyer CW et al. | β | 2004 | β |
| Artemis sheds new light on V(D)J recombination. | Le Deist F et al. | β | 2004 | β |
| A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes. | Furutani-Seiki M et al. | β | 2004 | β |
| Characterization of a new mouse mutant, flouncer, with a balance defect and inner ear malformation. | Pau H et al. | β | 2004 | β |
| Chemical mutagenesis of the mouse genome: an overview. | GuΓ©net JL | β | 2004 | β |
| Effects of G-protein mutations on skin color. | Van Raamsdonk CD et al. | β | 2004 | β |
| Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation. | Yusa K et al. | β | 2004 | β |
| ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. | Wu JY et al. | β | 2004 | β |
| Establishment of an efficient BAC transgenesis protocol and its application to functional characterization of the mouse Brachyury locus. | Abe K et al. | β | 2004 | β |
| Expanding the three Rs to meet new challenges in humane animal experimentation. | Schuppli CA et al. | β | 2004 | β |
| Functional annotation of mouse mutations in embryonic stem cells by use of expression profiling. | Symula DJ et al. | β | 2004 | β |
| Functional genomics tools for the analysis of zebrafish pigment. | Pickart MA et al. | β | 2004 | β |
| Genetically altered mice: phenotypes, no phenotypes, and Faux phenotypes. | Barthold SW | β | 2004 | β |
| Genomewide two-generation screens for recessive mutations by ES cell mutagenesis. | Munroe RJ et al. | β | 2004 | β |
| Genomics and clinical medicine: rationale for creating and effectively evaluating animal models. | Swanson KS et al. | β | 2004 | β |
| GSD: a genetic screen database. | Henrich T et al. | β | 2004 | β |
| Hypercholesterolemia in ENU-induced mouse mutants. | Mohr M et al. | β | 2004 | β |
| Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. | Schneider JE et al. | β | 2004 | β |
| Identification of radiation-sensitive mutants in the Medaka, Oryzias latipes. | Aizawa K et al. | β | 2004 | β |
| Identifying early vascular genes through gene trapping in mouse embryonic stem cells. | Kuhnert F et al. | β | 2004 | β |
| Implementing large-scale ENU mutagenesis screens in North America. | Clark AT et al. | β | 2004 | β |
| Inducible gene trapping with drug-selectable markers and Cre/loxP to identify developmentally regulated genes. | Chen YT et al. | β | 2004 | β |
| Mammalian circadian biology: elucidating genome-wide levels of temporal organization. | Lowrey PL et al. | β | 2004 | β |
| Modifier screens in the mouse: time to move forward with reverse genetics. | Curtis DJ | β | 2004 | β |
| Neurobehavioral assessment in the information age. | Tecott LH et al. | β | 2004 | β |
| New semidominant mutations that affect mouse development. | Bogani D et al. | β | 2004 | β |
| Rapid chromosomal assignment of medaka mutants by bulked segregant analysis. | Martinez-Morales JR et al. | β | 2004 | β |
| Screening for novel ENU-induced rhythm, entrainment and activity mutants. | Bacon Y et al. | β | 2004 | β |
| siRNAs: applications in functional genomics and potential as therapeutics. | Dorsett Y et al. | β | 2004 | β |
| Suppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling. | Carpinelli MR et al. | β | 2004 | β |
| Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice. | Branda CS et al. | β | 2004 | β |
| Target-selected mutagenesis of the rat. | Smits BM et al. | β | 2004 | β |
| The dominant alopecia phenotypes Bareskin, Rex-denuded, and Reduced Coat 2 are caused by mutations in gasdermin 3. | Runkel F et al. | β | 2004 | β |
| The European dimension for the mouse genome mutagenesis program. | Auwerx J et al. | β | 2004 | β |
| The G-netics of dark skin. | Jackson IJ | β | 2004 | β |
| Two kinds of ENU-induced scant hair mice and mapping of the mutant genes. | Wu BJ et al. | β | 2004 | β |
| Two new mouse chromosome 11 balancers. | Klysik J et al. | β | 2004 | β |
| Vascular occlusion and thrombosis in zebrafish. | Jagadeeswaran P et al. | β | 2004 | β |
| Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice. | Du X et al. | β | 2004 | β |
| A forward-genetic approach for analysis of the immune system. | Appleby MW et al. | β | 2003 | β |
| A genomewide screening of N-ethyl-N-nitrosourea-mutagenized mice for musculoskeletal phenotypes. | Srivastava AK et al. | β | 2003 | β |
| A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse. | Isaacs AM et al. | β | 2003 | β |
| An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse. | Percec I et al. | β | 2003 | β |
| Behavioural screening in mutagenised mice--in search for novel animal models of psychiatric disorders. | Ohl F et al. | β | 2003 | β |
| Characterization of Sleeping Beauty transposition and its application to genetic screening in mice. | Horie K et al. | β | 2003 | β |
| Characterization of trimethylpsoralen as a mutagen for mouse embryonic stem cells. | Greber B et al. | β | 2003 | β |
| Drug discovery perspective of chemical-driven mouse mutagenesis. | Xie W et al. | β | 2003 | β |
| Functional genomics of sleep. | Mackiewicz M et al. | β | 2003 | β |
| Genetics: a balancing act. | Rossant J | β | 2003 | β |
| Genetics of dark skin in mice. | Fitch KR et al. | β | 2003 | β |
| High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. | Valenzuela DM et al. | β | 2003 | β |
| Human and animal models of V(D)J recombination deficiency. | de Villartay JP et al. | β | 2003 | β |
| Integrative physiology and functional genomics of epithelial function in a genetic model organism. | Dow JT et al. | β | 2003 | β |
| Manipulation of the mouse genome: a multiple impact resource for drug discovery and development. | Prosser H et al. | β | 2003 | β |
| Mutagenesis strategies for identifying novel loci associated with disease phenotypes. | Brown SD et al. | β | 2003 | β |
| Mutations in dynein link motor neuron degeneration to defects in retrograde transport. | Hafezparast M et al. | β | 2003 | β |
| Phenotype-based identification of mouse chromosome instability mutants. | Shima N et al. | β | 2003 | β |
| Precision and accuracy of peripheral quantitative computed tomography (pQCT) in the mouse skeleton compared with histology and microcomputed tomography (microCT). | Schmidt C et al. | β | 2003 | β |
| Radiographic analysis of zebrafish skeletal defects. | Fisher S et al. | β | 2003 | β |
| Rodent models of genetic disease. | Cox RD et al. | β | 2003 | β |
| Specificity assessment from fractionation experiments (SAFE): a novel method to evaluate microarray probe specificity based on hybridisation stringencies. | Drobyshev AL et al. | β | 2003 | β |
| Target discovery. | Lindsay MA | β | 2003 | β |
| Target discovery and validation in the post-genomic era. | Butcher SP | β | 2003 | β |
| Technicolour transgenics: imaging tools for functional genomics in the mouse. | Hadjantonakis AK et al. | β | 2003 | β |
| The deaf mouse mutant Jeff (Jf) is a single gene model of otitis media. | Hardisty RE et al. | β | 2003 | β |
| Toward the genetics of mammalian reproduction: induction and mapping of gametogenesis mutants in mice. | Ward JO et al. | β | 2003 | β |
| Transposon mutagenesis of the mouse germline. | Carlson CM et al. | β | 2003 | β |
| Use of mouse genetics for studying inner ear development. | Quint E et al. | β | 2003 | β |
| Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. | Papathanasiou P et al. | β | 2003 | β |
| Zic2 is required for neural crest formation and hindbrain patterning during mouse development. | Elms P et al. | β | 2003 | β |
| A gene-driven approach to the identification of ENU mutants in the mouse. | Coghill EL et al. | β | 2002 | β |
| A new ultrasound instrument for in vivo microimaging of mice. | Foster FS et al. | β | 2002 | β |
| Beethoven, a mouse model for dominant, progressive hearing loss DFNA36. | Vreugde S et al. | β | 2002 | β |
| Building-blocks of embryogenesis. | Mullins MC | β | 2002 | β |
| Complexities of cancer research: mouse genetic models. | Hunter KW et al. | β | 2002 | β |
| Deductive genomics: a functional approach to identify innovative drug targets in the post-genome era. | Stumm G et al. | β | 2002 | β |
| Efficient generation and mapping of recessive developmental mutations using ENU mutagenesis. | Herron BJ et al. | β | 2002 | β |
| ENU mutagenesis reveals a highly mutable locus on mouse Chromosome 4 that affects ear morphogenesis. | Kiernan AE et al. | β | 2002 | β |
| Focusing on the genetics of hearing: you ain't heard nothin' yet. | Parkinson N et al. | β | 2002 | β |
| Full-speed mammalian genetics: in vivo target validation in the drug discovery process. | Abuin A et al. | β | 2002 | β |
| Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: a fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15. | Rinchik EM et al. | β | 2002 | β |
| Genetically engineered mice for studies of stress-related clinical conditions. | MΓΌller MB et al. | β | 2002 | β |
| Genetic and physical maps of jerker (Espn(je)) on mouse chromosome 4. | Jackson T et al. | β | 2002 | β |
| Genetic contributions to addiction. | Crabbe JC | β | 2002 | β |
| Genetics of sensory mechanotransduction. | Ernstrom GG et al. | β | 2002 | β |
| Genetic strategies to detect genes involved in alcoholism and alcohol-related traits. | Dick DM et al. | β | 2002 | β |
| High-throughput selection of retrovirus producer cell lines leads to markedly improved efficiency of germ line-transmissible insertions in zebra fish. | Chen W et al. | β | 2002 | β |
| Large-scale mutational analysis for the annotation of the mouse genome. | Beckers J et al. | β | 2002 | β |
| Mouse models for human deafness: current tools for new fashions. | Ahituv N et al. | β | 2002 | β |
| Mouse models for neurological disease. | Hafezparast M et al. | β | 2002 | β |
| Mouse models for the genetic dissection of atopy. | Heinzmann A et al. | β | 2002 | β |
| Novel approaches for identifying genes regulating lymphocyte development and function. | Loy AL et al. | β | 2002 | β |
| Random mutagenesis in the mouse as a tool in drug discovery. | Russ A et al. | β | 2002 | β |
| Surviving a knockout blow. | Pearson H | β | 2002 | β |
| Teratogenic effects of N-ethyl-N-nitrosourea (ENU) on larvae of the self-fertilizing fish Rivulus marmoratus (Cyprinodontiformes, Rivulidae). | Lee JS et al. | β | 2002 | β |
| The fallacy of behavioral phenotyping without standardisation. | van der Staay FJ et al. | β | 2002 | β |
| The genetics of deafness: a model for genomic and biological complexity. | Avraham KB | β | 2002 | β |
| Tools for targeted manipulation of the mouse genome. | van der Weyden L et al. | β | 2002 | β |
| Transgenic systems in drug discovery: from target identification to humanized mice. | TΓΆrnell J et al. | β | 2002 | β |
| Understanding the human condition: experimental strategies in mammalian genetics. | Paigen K | β | 2002 | β |
| Unravelling novel intracellular pathways in cell-based assays. | Giese K et al. | β | 2002 | β |
| Using mouse models to dissect the genetics of obesity. | Brockmann GA et al. | β | 2002 | β |
| A biochemical function for attractin in agouti-induced pigmentation and obesity. | He L et al. | β | 2001 | β |
| A radiation hybrid transcript map of the mouse genome. | Avner P et al. | β | 2001 | β |
| Behavioural phenotyping of mouse mutants. | van der Staay FJ et al. | β | 2001 | β |
| Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a dominant cataract. | Graw J et al. | β | 2001 | β |
| Chimera analysis of the Clock mutation in mice shows that complex cellular integration determines circadian behavior. | Low-Zeddies SS et al. | β | 2001 | β |
| Chromosomal microdeletions: dissecting del22q11 syndrome. | Lindsay EA | β | 2001 | β |
| Defining brain wiring patterns and mechanisms through gene trapping in mice. | Leighton PA et al. | β | 2001 | β |
| Efficient chromosomal transposition of a Tc1/mariner- like transposon Sleeping Beauty in mice. | Horie K et al. | β | 2001 | β |
| Efficient gene transfer into the embryonic mouse brain using in vivo electroporation. | Saito T et al. | β | 2001 | β |
| Enu mouse mutagenesis: generation of mouse mutants with aberrant plasma IgE levels. | Alessandrini F et al. | β | 2001 | β |
| ENU mutagenesis: analyzing gene function in mice. | Balling R | β | 2001 | β |
| Fishing for lymphoid genes. | Trede NS et al. | β | 2001 | β |
| Functional analysis of secreted and transmembrane proteins critical to mouse development. | Mitchell KJ et al. | β | 2001 | β |
| Functional genomics of the murine immune system. | Ruley HE | β | 2001 | β |
| Functional genomics the old-fashioned way: chemical mutagenesis in mice. | Inamdar MS | β | 2001 | β |
| Gene targeting reveals a role for the glutamate receptors mGluR5 and GluR2 in learning and memory. | Jia Z et al. | β | 2001 | β |
| Gene-trap mutagenesis: past, present and beyond. | Stanford WL et al. | β | 2001 | β |
| Genome-wide ENU mutagenesis to reveal immune regulators. | Nelms KA et al. | β | 2001 | β |
| Genome-wide search for loci controlling serum IGF binding protein levels of mice. | Brockmann GA et al. | β | 2001 | β |
| Genomics: saviour or millstone? | Rastan S | β | 2001 | β |
| Intraocular pressure in genetically distinct mice: an update and strain survey. | Savinova OV et al. | β | 2001 | β |
| Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus. | Favor J et al. | β | 2001 | β |
| Mouse-based phenogenomics for modelling human disease. | Rossant J et al. | β | 2001 | β |
| Mouse models of blood pressure regulation and hypertension. | Sugiyama F et al. | β | 2001 | β |
| Mouse mutagenesis on target. | Jackson IJ | β | 2001 | β |
| Mutagenesis screens: can they be justified? | Jenkins ES et al. | β | 2001 | β |
| Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: annotated tables. | Nakamura M et al. | β | 2001 | β |
| Mutations of the mouse Twist and sy (fibrillin 2) genes induced by chemical mutagenesis of ES cells. | Browning VL et al. | β | 2001 | β |
| Protein--protein interaction maps: a lead towards cellular functions. | Legrain P et al. | β | 2001 | β |
| QTL analysis and genomewide mutagenesis in mice: complementary genetic approaches to the dissection of complex traits. | Belknap JK et al. | β | 2001 | β |
| Sensitized polygenic trait analysis. | Matin A et al. | β | 2001 | β |
| Sequence interpretation. Functional annotation of mouse genome sequences. | Nadeau JH et al. | β | 2001 | β |
| Taking a functional genomics approach in molecular medicine. | Yaspo ML | β | 2001 | β |
| The genetic architecture of quantitative traits. | Mackay TF | β | 2001 | β |
| The molecular neurobiology of stress--evidence from genetic and epigenetic models. | Steckler T | β | 2001 | β |
| The Notch ligand Jagged1 is required for inner ear sensory development. | Kiernan AE et al. | β | 2001 | β |
| The trappist's approach to pathfinding: elucidating brain wiring using secretory-trap mutagenesis. | Furley AJ | β | 2001 | β |
| The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects. | Alavizadeh A et al. | β | 2001 | β |
| Transposition and gene disruption in the male germline of the mouse. | Dupuy AJ et al. | β | 2001 | β |
| Using mouse genetics to understand infectious disease pathogenesis. | Dietrich WF | β | 2001 | β |
| What can the neurobiologist learn from mapping genes linked with behavioral traits? | Roubertoux PL | β | 2001 | β |
| A mutant mouse menagerie. | Abbott A | β | 2000 | β |
| A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse. | Nolan PM et al. | β | 2000 | β |
| Auditory and vestibular mouse mutants: models for human deafness. | Ahituv N et al. | β | 2000 | β |
| Capitalizing on large-scale mouse mutagenesis screens. | Justice MJ | β | 2000 | β |
| Chemical genetics: ligand-based discovery of gene function. | Stockwell BR | β | 2000 | β |
| Genomics. Beyond the book of life. | Aldhous P | β | 2000 | β |
| Perspectives for vascular genomics. | Rubin EM et al. | β | 2000 | β |
| The roads from phenotypic variation to gene discovery: mutagenesis versus QTLs. | Nadeau JH et al. | β | 2000 | β |
| Transgenic gene knock-outs: functional genomics and therapeutic target selection. | Harris S et al. | β | 2000 | β |