Cornichons modify channel properties of recombinant and glial AMPA receptors.
paper
Cited
Public
Unavailable
- Authors
- Coombs, Ian D; Soto, David; Zonouzi, Marzieh; Renzi, Massimiliano; Shelley, Chris; Farrant, Mark; Cull-Candy, Stuart G
- Year
- 2012
- Journal
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- PMID
- 22815494
- DOI
- 10.1523/JNEUROSCI.0345-12.2012
- PMCID
- PMC3428874
Ionotropic glutamate receptors, which underlie a majority of excitatory synaptic transmission in the CNS, associate with transmembrane proteins that modify their intracellular trafficking and channel gating. Significant advances have been made in our understanding of AMPA-type glutamate receptor (AMPAR) regulation by transmembrane AMPAR regulatory proteins. Less is known about the functional influence of cornichons-unrelated AMPAR-interacting proteins, identified by proteomic analysis. Here we confirm that cornichon homologs 2 and 3 (CNIH-2 and CNIH-3), but not CNIH-1, slow the deactivation and desensitization of both GluA2-containing calcium-impermeable and GluA2-lacking calcium-permeable (CP) AMPARs expressed in tsA201 cells. CNIH-2 and -3 also enhanced the glutamate sensitivity, single-channel conductance, and calcium permeability of CP-AMPARs while decreasing their block by intracellular polyamines. We examined the potential effects of CNIHs on native AMPARs by recording from rat optic nerve oligodendrocyte precursor cells (OPCs), known to express a significant population of CP-AMPARs. These glial cells exhibited surface labeling with an anti-CNIH-2/3 antibody. Two features of their AMPAR-mediated currents-the relative efficacy of the partial agonist kainate (I(KA)/I(Glu) ratio 0.4) and a greater than fivefold potentiation of kainate responses by cyclothiazide-suggest AMPAR association with CNIHs. Additionally, overexpression of CNIH-3 in OPCs markedly slowed AMPAR desensitization. Together, our experiments support the view that CNIHs are capable of altering key properties of AMPARs and suggest that they may do so in glia.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Assembly and gating mechanism of native AMPA receptors from the cerebellum. | Li X et al. | β | 2026 | β |
| From Atoms to Neuronal Spikes: A Multiscale Simulation Framework. | Damjanovic A et al. | β | 2026 | β |
| Generalised Hodgkin-Huxley model captures human P2X and AMPA receptor currents. | Poshtkohi A et al. | β | 2026 | β |
| Trafficking of the human Na<sup>+</sup>/H<sup>+</sup> antiporter NHA2 to the plasma membrane requires cornichon COPII cargo receptors. | KacovskΓ‘ K et al. | β | 2026 | β |
| Gating and noelin clustering of native Ca<sup>2+</sup>-permeable AMPA receptors. | Fang C et al. | β | 2025 | β |
| Genome-wide association meta-analyses of drug-resistant epilepsy. | Leu C et al. | β | 2025 | β |
| Intracellular Spermine Is a Key Player in GSG1L's Regulation of Calcium-Permeable AMPAR Channel Conductance and Recovery from Desensitization. | McGee TP et al. | β | 2025 | β |
| Modeling the use of transient ligand binding information by AMPA receptors. | Braunstein H et al. | β | 2025 | β |
| Synaptic proteome diversity is shaped by the levels of glutamate receptors and their regulatory proteins. | Reig-Viader R et al. | β | 2025 | β |
| Structural dynamics in Ξ±-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor gating. | Gonzalez CU et al. | β | 2024 | β |
| The Role of Cornichons in the Biogenesis and Functioning of Monovalent-Cation Transport Systems. | PapouΕ‘kovΓ‘ K et al. | β | 2024 | β |
| Alternative Splicing of the Flip/Flop Cassette and TARP Auxiliary Subunits Engage in a Privileged Relationship That Fine-Tunes AMPA Receptor Gating. | Perozzo AM et al. | β | 2023 | β |
| Differential regulation of tetramerization of the AMPA receptor glutamate-gated ion channel by auxiliary subunits. | Certain N et al. | β | 2023 | β |
| Enhanced functional detection of synaptic calcium-permeable AMPA receptors using intracellular NASPM. | Coombs I et al. | β | 2023 | β |
| GSG1L-containing AMPA receptor complexes are defined by their spatiotemporal expression, native interactome and allosteric sites. | Perozzo AM et al. | β | 2023 | β |
| <i>Cnih3</i> Deletion Dysregulates Dorsal Hippocampal Transcription across the Estrous Cycle. | Mulvey B et al. | β | 2023 | β |
| Merging Signaling with Structure: Functions and Mechanisms of Plant Glutamate Receptor Ion Channels. | Simon AA et al. | β | 2023 | β |
| Modulation of GluA2-Ξ³5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. | Gangwar SP et al. | β | 2023 | β |
| Purification and biochemical analysis of native AMPA receptors from three different mammalian species. | Rao P et al. | β | 2023 | β |
| Influence of the TARP Ξ³8-Selective Negative Allosteric Modulator JNJ-55511118 on AMPA Receptor Gating and Channel Conductance. | Coombs ID et al. | β | 2022 | β |
| Novel digital approaches to the assessment of problematic opioid use. | Freda PJ et al. | β | 2022 | β |
| Preliminary Study of Genome-Wide Association Identified Novel Susceptibility Genes for Hemorheological Indexes in a Chinese Population. | Sun Y et al. | β | 2022 | β |
| Structural insights into function of ionotropic glutamate receptors. | Yelshanskaya MV et al. | β | 2022 | β |
| AMPA receptor structure and auxiliary subunits. | Kamalova A et al. | β | 2021 | β |
| Auxiliary Subunits Control Function and Subcellular Distribution of AMPA Receptor Complexes in NG2 Glia of the Developing Hippocampus. | Hardt S et al. | β | 2021 | β |
| Building of AMPA-type glutamate receptors in the endoplasmic reticulum and its implication for excitatory neurotransmission. | Schwenk J et al. | β | 2021 | β |
| Ca<sup>2+</sup> -permeable AMPA receptors and their auxiliary subunits in synaptic plasticity and disease. | Cull-Candy SG et al. | β | 2021 | β |
| Gating and modulation of a hetero-octameric AMPA glutamate receptor. | Zhang D et al. | β | 2021 | β |
| Modulation of information processing by AMPA receptor auxiliary subunits. | Jacobi E et al. | β | 2021 | β |
| Sex Differences in the Role of CNIH3 on Spatial Memory and Synaptic Plasticity. | Frye HE et al. | β | 2021 | β |
| Single-channel mechanisms underlying the function, diversity and plasticity of AMPA receptors. | Coombs ID et al. | β | 2021 | β |
| Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels. | Hansen KB et al. | β | 2021 | β |
| Structure of the Arabidopsis Glutamate Receptor-like Channel GLR3.2 Ligand-Binding Domain. | Gangwar SP et al. | β | 2021 | β |
| AMPA receptor auxiliary subunits emerged during early vertebrate evolution by neo/subfunctionalization of unrelated proteins. | Ramos-Vicente D et al. | β | 2020 | β |
| Interplay between Gating and Block of Ligand-Gated Ion Channels. | Phillips MB et al. | β | 2020 | β |
| Molecular insights into the role of AMPA receptors in the synaptic plasticity, pathogenesis and treatment of epilepsy: therapeutic potentials of perampanel and antisense oligonucleotide (ASO) technology. | Charsouei S et al. | β | 2020 | β |
| AMPA receptors and their minions: auxiliary proteins in AMPA receptor trafficking. | Bissen D et al. | β | 2019 | β |
| An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity. | Schwenk J et al. | β | 2019 | β |
| Homomeric GluA2(R) AMPA receptors can conduct when desensitized. | Coombs ID et al. | β | 2019 | β |
| Homomeric Q/R edited AMPA receptors conduct when desensitized | Coombs ID et al. | β | 2019 | β |
| Presynaptic Diversity Revealed by Ca<sup>2+</sup>-Permeable AMPA Receptors at the Calyx of Held Synapse. | Lujan B et al. | β | 2019 | β |
| Auxiliary subunits of AMPA receptors: The discovery of a forebrain-selective antagonist, LY3130481/CERC-611. | Kato AS et al. | β | 2018 | β |
| Ion permeation in ionotropic glutamate receptors: Still dynamic after all these years. | Wollmuth LP | β | 2018 | β |
| Polyamine-mediated channel block of ionotropic glutamate receptors and its regulation by auxiliary proteins. | Bowie D | β | 2018 | β |
| Stargazin and cornichon-3 relieve polyamine block of AMPA receptors by enhancing blocker permeation. | Brown PMGE et al. | β | 2018 | β |
| Ferric Chelate Reductase 1 Like Protein (FRRS1L) Associates with Dynein Vesicles and Regulates Glutamatergic Synaptic Transmission. | Han W et al. | β | 2017 | β |
| GSG1L regulates the strength of AMPA receptor-mediated synaptic transmission but not AMPA receptor kinetics in hippocampal dentate granule neurons. | Mao X et al. | β | 2017 | β |
| Opposite, bidirectional shifts in excitation and inhibition in specific types of dorsal horn interneurons are associated with spasticity and pain post-SCI. | Kopach O et al. | β | 2017 | β |
| Optical inactivation of synaptic AMPA receptors erases fear memory. | Takemoto K et al. | β | 2017 | β |
| Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins. | Greger IH et al. | β | 2017 | β |
| The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory. | Schmitz LJM et al. | β | 2017 | β |
| The Inhibitory Effect of Ξ±/Ξ²-Hydrolase Domain-Containing 6 (ABHD6) on the Surface Targeting of GluA2- and GluA3-Containing AMPA Receptors. | Wei M et al. | β | 2017 | β |
| Evidence of CNIH3 involvement in opioid dependence. | Nelson EC et al. | β | 2016 | β |
| GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. | Gu X et al. | β | 2016 | β |
| Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity. | Klaassen RV et al. | β | 2016 | β |
| Ξ±/Ξ²-Hydrolase domain-containing 6 (ABHD6) negatively regulates the surface delivery and synaptic function of AMPA receptors. | Wei M et al. | β | 2016 | β |
| Advances in the pharmacology of lGICs auxiliary subunits. | Galaz P et al. | β | 2015 | β |
| Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. | McGee TP et al. | β | 2015 | β |
| Modulation of non-NMDA receptor gating by auxiliary subunits. | Howe JR | β | 2015 | β |
| Oligodendrocyte Development and Plasticity. | Bergles DE et al. | β | 2015 | β |
| Transmembrane AMPAR regulatory protein Ξ³-2 is required for the modulation of GABA release by presynaptic AMPARs. | Rigby M et al. | β | 2015 | β |
| AMPAR interacting protein CPT1C enhances surface expression of GluA1-containing receptors. | GratacΓ²s-Batlle E et al. | β | 2014 | β |
| Auxiliary subunits: shepherding AMPA receptors to the plasma membrane. | Haering SC et al. | β | 2014 | β |
| Cornichon2 dictates the time course of excitatory transmission at individual hippocampal synapses. | Boudkkazi S et al. | β | 2014 | β |
| Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. | Poulsen MH et al. | β | 2014 | β |
| Inhibition of AMPA receptors by polyamine toxins is regulated by agonist efficacy and stargazin. | Poulsen MH et al. | β | 2014 | β |
| Molecular dissection of the interaction between the AMPA receptor and cornichon homolog-3. | Shanks NF et al. | β | 2014 | β |
| Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors. | Soto D et al. | β | 2014 | β |
| More than a pore: ion channel signaling complexes. | Lee A et al. | β | 2014 | β |
| Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain. | Schwenk J et al. | β | 2014 | β |
| Stargazin promotes closure of the AMPA receptor ligand-binding domain. | MacLean DM et al. | β | 2014 | β |
| The physiology of mechanoelectrical transduction channels in hearing. | Fettiplace R et al. | β | 2014 | β |
| AMPARs and synaptic plasticity: the last 25 years. | Huganir RL et al. | β | 2013 | β |
| Cornichons control ER export of AMPA receptors to regulate synaptic excitability. | Brockie PJ et al. | β | 2013 | β |
| Extrasynaptic AMPA receptors in the dorsal horn: evidence and functional significance. | Kopach O et al. | β | 2013 | β |
| Ontogeny repeats the phylogenetic recruitment of the cargo exporter cornichon into AMPA receptor signaling complexes. | Mauric V et al. | β | 2013 | β |
| The role of transmembrane channel-like proteins in the operation of hair cell mechanotransducer channels. | Kim KX et al. | β | 2013 | β |