Emerging roles of PPARs in inflammation and immunity.
paper
Cited
Public
Unavailable
- Authors
- Daynes, Raymond A; Jones, Dallas C
- Year
- 2002
- Journal
- Nature reviews. Immunology
- PMID
- 12360213
- DOI
- 10.1038/nri912
Lipids and lipid metabolism have well-documented regulatory effects on inflammatory processes. Recent work has highlighted the role of the peroxisome proliferator-activated receptors (PPARs)--a subset of the nuclear-hormone-receptor superfamily that are activated by various lipid species--in regulating inflammatory responses. Here, we describe how the PPARs, through their interactions with transcription factors and other cell-signalling systems, have important regulatory roles in innate and adaptive immunity.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| APOE4 drives maladaptive heterogeneity and immunometabolic responses of astrocytes. | Goulding DS et al. | β | 2026 | β |
| Identification and expression analysis of long noncoding RNAs in response to infection with VHSV in rainbow trout. | Tavakoli-Alamouti M et al. | β | 2026 | β |
| Intercellular Communication as a Key Driver: Insights Into Peritoneal Dialysis-Associated Peritoneal Fibrosis. | Li J et al. | β | 2026 | β |
| Nuclear receptors in age-related diseases: From mechanisms to drug discovery. | Zhang L et al. | β | 2026 | β |
| Regulation of Lipid Dysmetabolism and Neuroinflammation Progression Linked With Alzheimer's Disease Through Modulation of Dgat2. | Yadav A et al. | β | 2026 | β |
| Activation of peroxisome proliferator-activated receptor (PPAR) by pioglitazone in oral traumatic ulcers in female rats. | Neto RSM et al. | β | 2025 | β |
| Alopecia areata: from immunopathogenesis to emerging therapeutic approaches. | Kim SY et al. | β | 2025 | β |
| Anti-inflammatory and immunomodulatory effects of valproate and carbamazepine involve distinct signaling in human peripheral blood mononuclear cells. | PopoviΔ G et al. | β | 2025 | β |
| Boswellia Extract Promotes Healing and Resolving Inflammation in Oral Ulcers of Rat. | Zhao W et al. | β | 2025 | β |
| Cannabidiol reduces neuropathic pain and cognitive impairments through activation of spinal PPARΞ³. | Islas-Espinoza AM et al. | β | 2025 | β |
| Caveolin-1/PPARΞ± axis suppresses T follicular helper cell response in primary SjΓΆgren disease. | Yu S et al. | β | 2025 | β |
| Cell polarization in ischemic stroke: molecular mechanisms and advances. | Li Y et al. | β | 2025 | β |
| Chiglitazar, a PPAR pan-agonist: Impacts on type 2 diabetes mellitus and multi-system metabolic regulation - A review. | Chang E et al. | β | 2025 | β |
| Elucidating the mechanistic relationships between peroxisome proliferator-activated receptors and hepatic fibrosis using the ROBOKOP knowledge graph. | Fecho K et al. | β | 2025 | β |
| Enzyme-responsive oleoylethanolamide-releasing nanomedicine for sustained liver delivery and therapeutic improvement in early-stage metabolic dysfunction-associated steatohepatitis (MASH). | Ding Y et al. | β | 2025 | β |
| Exploring allosteric properties of mammalian ALOX15: octyl (<i>N</i>-(4-(benzofuran-2-yl)-2-methoxyphenyl)sulfamoyl)- and octyl (<i>N</i>-(4-(1<i>H</i>-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamates as ALOX inhibitors. | Gavrilyuk V et al. | β | 2025 | β |
| Health Benefits of Phytosterols in the Management of Several Non-Communicable Disorders. | Aboutaleb AS et al. | β | 2025 | β |
| Identification and Validation of Oxidative Stress-Related Diagnostic Marker Genes and Immune Landscape in Ulcerative Interstitial Cystitis by Integrating Bioinformatics and Machine Learning. | Fu C et al. | β | 2025 | β |
| Interplay of NF-ΞΊB and PPAR-Ξ³ transcription factors in patients with juvenile systemic lupus erythematosus. | Durmus S et al. | β | 2025 | β |
| Metabolic Reprogramming of Anti-cancer T Cells: Targeting AMPK and PPAR to Optimize Cancer Immunotherapy. | Jalil AT et al. | β | 2025 | β |
| Mitigation of radiation mediated testicular dysfunction by Ξ±-tocopheryl succinate: PPAR-Ξ³ related pathway. | Gheita HA et al. | β | 2025 | β |
| Neuroprotective role of rice bran extract and its constituents in a neuroinflammatory mouse model. | El-Nagah SMA et al. | β | 2025 | β |
| Phthalates and uterine disorders. | Yang S et al. | β | 2025 | β |
| Potentials of peroxisome proliferator-activated receptor (PPAR) Ξ±, Ξ²/Ξ΄, and Ξ³: An in-depth and comprehensive review of their molecular mechanisms, cellular Signalling, immune responses and therapeutic implications in multiple diseases. | Singh A et al. | β | 2025 | β |
| Quantitation of global histone post-translational modifications reveal anti-inflammatory epigenetic mechanisms of liquiritigenin based on the optimized super-SILAC strategy. | Liu P et al. | β | 2025 | β |
| Targeting inflammation and necroptosis in diabetic kidney disease: A novel approach via PPARΞ± modulation. | Wang Y et al. | β | 2025 | β |
| Troglitazone Reduction of Intracellular Mycobacterium tuberculosis Survival Via Macrophage Autophagy Through LKB1-AMPKΞ± Signaling. | Bi J et al. | β | 2025 | β |
| Understanding the peroxisome proliferator-activated receptor gamma (PPAR-Ξ³) role in periodontitis and diabetes mellitus: A molecular perspective. | Nicchio IG et al. | β | 2025 | β |
| Unraveling the Function of PPARΞ± in Neurodegenerative Disorders: A Potential Pathway to Novel Therapies. | Galanou ON et al. | β | 2025 | β |
| Unveiling the mechanism of amelioration of adjuvant-induced rheumatoid arthritis by Drynaria quercifolia rhizome extract using network pharmacology and gene expression-based studies. | Modak D et al. | β | 2025 | β |
| Utilization of Cannabidiol in Post-Organ-Transplant Care. | Koyama S et al. | β | 2025 | β |
| Chrysin inhibits adipogenesis by modulating PPARΞ³: <i>in silico</i> and <i>inΒ vitro</i> studies. | Soumya SJ et al. | β | 2024 | β |
| Determination of <i>in vitro</i> immunotoxic potencies of a series of perfluoralkylsubstances (PFASs) in human Namalwa B lymphocyte and human Jurkat T lymphocyte cells. | Janssen AWF et al. | β | 2024 | β |
| Enhanced fatty acid oxidation by selective activation of PPARΞ± alleviates autoimmunity through metabolic transformation in T-cells. | Masuyama S et al. | β | 2024 | β |
| FABP7 drives an inflammatory response in human astrocytes and is upregulated in Alzheimer's disease. | Hamilton HL et al. | β | 2024 | β |
| Gut microbiota analysis and LC-MS-based metabolomics to investigate AMPK/NF-ΞΊB regulated by Clostridium butyricum in the treatment of acute pancreatitis. | Wen B et al. | β | 2024 | β |
| Highly potent and selective PPARΞ΄ agonist reverses memory deficits in mouse models of Alzheimer's disease. | Kim HJ et al. | β | 2024 | β |
| <i>Lespedeza homoloba</i> enhances the immunosuppressive milieu of adipose tissue and suppresses fasting blood glucose. | Kobayashi K et al. | β | 2024 | β |
| Impact of dietary changes on retinal neuronal plasticity in rodent models of physical and psychological trauma. | Patel MY et al. | β | 2024 | β |
| Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation. | Madhvapathy SR et al. | β | 2024 | β |
| Multi-omics analysis provides new insights into mechanism of didymin on non-alcoholic fatty liver disease in rats. | Fang B et al. | β | 2024 | β |
| NADPH Oxidase 3: Beyond the Inner Ear. | Herb M | β | 2024 | β |
| New insights in lipid metabolism: potential therapeutic targets for the treatment of Alzheimer's disease. | Cao Y et al. | β | 2024 | β |
| Oral administration of obeldesivir protects nonhuman primates against <i>Sudan ebolavirus</i>. | Cross RW et al. | β | 2024 | β |
| Pioglitazone attenuates behavioral and electrophysiological dysfunctions induced by two-hit model of schizophrenia in adult rodent offspring. | Sonego AB et al. | β | 2024 | β |
| Structural and Functional Biology of Mammalian ALOX Isoforms with Particular Emphasis on Enzyme Dimerization and Their Allosteric Properties. | Zhuravlev A et al. | β | 2024 | β |
| The emerging role of brain neuroinflammatory responses in Alzheimer's disease. | Amelimojarad M et al. | β | 2024 | β |
| The neuroinflammatory role of microglia in Alzheimer's disease and their associated therapeutic targets. | AmeliMojarad M et al. | β | 2024 | β |
| Transcriptomic analysis of intestine following administration of a transglutaminase 2 inhibitor to prevent gluten-induced intestinal damage in celiac disease. | Dotsenko V et al. | β | 2024 | β |
| Unburned Tobacco Smoke Affects Neuroinflammation-Related Pathways in the Rat Mesolimbic System. | Morosini C et al. | β | 2024 | β |
| A Systematic Review of Host Genomic Variation and Neuropsychological Outcomes for Pediatric Cancer Survivors. | Kautiainen R et al. | β | 2023 | β |
| Concomitant inhibition of PPARΞ³ and mTORC1 induces the differentiation of human monocytes into highly immunogenic dendritic cells. | Erra Diaz F et al. | β | 2023 | β |
| Consideration of pathways for immunotoxicity of per- and polyfluoroalkyl substances (PFAS). | Ehrlich V et al. | β | 2023 | β |
| Design and Synthesis of l-1'-Homologated Adenosine Derivatives as Potential Anti-inflammatory Agents. | Nguyen M et al. | β | 2023 | β |
| Differential effects of plant and animal fats on obesity-induced dyslipidemia and atherosclerosis in Ldlr-/-.Leiden mice. | Morrison MC et al. | β | 2023 | β |
| Different Structures-Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1<i>H</i>-indoles and 5-(4-Methoxyphenyl)-1<i>H</i>-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15? | Zhuravlev A et al. | β | 2023 | β |
| Hydrogen sulfide ameliorates senescence in vascular endothelial cells through ameliorating inflammation and activating PPARΞ΄/SGLT2/STAT3 signaling pathway. | Tian D et al. | β | 2023 | β |
| Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise. | Yin F | β | 2023 | β |
| Mammalian lipid droplets: structural, pathological, immunological and anti-toxicological roles. | Hammoudeh N et al. | β | 2023 | β |
| Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics. | Barosova R et al. | β | 2023 | β |
| Multi-Target Neuroprotection of Thiazolidinediones on Alzheimer's Disease via Neuroinflammation and Ferroptosis. | Yang J et al. | β | 2023 | β |
| Neuroprotective potential of cannabidiol: Molecular mechanisms and clinical implications. | Tambe SM et al. | β | 2023 | β |
| Peptide Helix-Y<sup>12</sup> as Potential Effector for Peroxisome Proliferator-Activated Receptors. | Carrillo-Tripp M et al. | β | 2023 | β |
| Peroxisome Proliferator-Activated Receptor-Targeted Therapies: Challenges upon Infectious Diseases. | Kim IS et al. | β | 2023 | β |
| Peroxisome Proliferator-Activated Receptor Ξ± in Lipoprotein Metabolism and Atherosclerotic Cardiovascular Disease. | Fuior EV et al. | β | 2023 | β |
| PPAR Pan Agonist MHY2013 Alleviates Renal Fibrosis in a Mouse Model by Reducing Fibroblast Activation and Epithelial Inflammation. | Son M et al. | β | 2023 | β |
| PparΞ± knockout in mice increases the Th17 development by facilitating the IKKΞ±/RORΞ³t and IKKΞ±/Foxp3 complexes. | Wei P et al. | β | 2023 | β |
| Rumen microbiota-host transcriptome interaction mediates the protective effects of <i>trans</i>-10, <i>cis</i>-12 CLA on facilitating weaning transition of lambs. | Yang C et al. | β | 2023 | β |
| Signaling pathways in macrophages: molecular mechanisms and therapeutic targets. | Li M et al. | β | 2023 | β |
| Structure-Activity Relationships of Truncated 1'-Homologated Carbaadenosine Derivatives as New PPARΞ³/Ξ΄ Ligands: A Study on Sugar Puckering Affecting Binding to PPARs. | Hyun YE et al. | β | 2023 | β |
| The effect of nutritional interventions reducing oxidative stress on behavioural and gastrointestinal problems in autism spectrum disorder. | Colak H et al. | β | 2023 | β |
| The nuclear cytokine IL-37a controls lethal cytokine storms primarily via IL-1R8-independent transcriptional upregulation of PPARΞ³. | Wei R et al. | β | 2023 | β |
| Therapeutic roles of PPARΞ± activation in ocular ischemic diseases. | Lee D et al. | β | 2023 | β |
| The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy. | Hasankhani A et al. | β | 2023 | β |
| Thiazolidinediones lower the risk of pneumonia in patients with type 2 diabetes. | Yen FS et al. | β | 2023 | β |
| Analysis and identification of potential type II helper T cell (Th2)-Related key genes and therapeutic agents for COVID-19. | Jin Q et al. | β | 2022 | β |
| Anti-allergic effect of ascorbic acid derivative DDH-1 in a mouse model of atopic dermatitis. | Kitahata K et al. | β | 2022 | β |
| Cannabidiol for neurodegenerative disorders: A comprehensive review. | Bhunia S et al. | β | 2022 | β |
| CREB1 and PPAR-Ξ±/Ξ³ Pathways in Hepatic Ischemia/Reperfusion: Route for Curcumin to Hepatoprotection. | Demir EA et al. | β | 2022 | β |
| Global Trends in Research of Lipid Metabolism in T lymphocytes From 1985 to 2022: A Bibliometric Analysis. | Chen P et al. | β | 2022 | β |
| Hyperandrogenism and Polycystic ovary syndrome: Effects in pregnancy and offspring development. | Abruzzese GA et al. | β | 2022 | β |
| <i>Bifidobacterium animalis</i> KV9 and <i>Lactobacillus vaginalis</i> FN3 alleviated Ξ²-lactoglobulin-induced allergy by modulating dendritic cells in mice. | Tian X et al. | β | 2022 | β |
| Integrative transcriptomic analysis in human and mouse model of anaphylaxis identifies gene signatures associated with cell movement, migration and neuroinflammatory signalling. | Rijavec M et al. | β | 2022 | β |
| Lipid metabolism in autoimmune rheumatic disease: implications for modern and conventional therapies. | Robinson G et al. | β | 2022 | β |
| Low-Concentrations of Fatty Acids Induce an Early Increase in IL-8 Levels in Normal Human Astrocytes. | Dobri AM et al. | β | 2022 | β |
| Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis. | Heaven MR et al. | β | 2022 | β |
| Microglial Immunoregulation by Apoptotic Cellular Membrane Mimetic Polymeric Particles. | Nakagawa Y et al. | β | 2022 | β |
| Palmitoylethanolamide Reduces Proinflammatory Markers in Unvaccinated Adults Recently Diagnosed with COVID-19: A Randomized Controlled Trial. | Fessler SN et al. | β | 2022 | β |
| Peroxisome Proliferator-Activated Receptors and the Hallmarks of Cancer. | Wagner N et al. | β | 2022 | β |
| Plasma concentrations of perfluoroalkyl substances and risk of inflammatory bowel diseases in women: A nested case control analysis in the Nurses' Health Study cohorts. | Lochhead P et al. | β | 2022 | β |
| Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimer's disease. | Gupta C et al. | β | 2022 | β |
| Single-cell network biology characterizes cell type gene regulation for drug repurposing and phenotype prediction in Alzheimerβs disease | Gupta C et al. | β | 2022 | β |
| Synaptic Effects of Palmitoylethanolamide in Neurodegenerative Disorders. | Assogna M et al. | β | 2022 | β |
| Systematic evaluation of irinotecan-induced intestinal mucositis based on metabolomics analysis. | Yu QQ et al. | β | 2022 | β |
| The first human induced pluripotent stem cell line of Kashin-Beck disease reveals involvement of heparan sulfate proteoglycan biosynthesis and PPAR pathway. | Liu H et al. | β | 2022 | β |
| The immune response as a therapeutic target in non-alcoholic fatty liver disease. | Ortiz-LΓ³pez N et al. | β | 2022 | β |
| The pleiotropic peroxisome proliferator activated receptors: Regulation and therapeutics. | Dixit G et al. | β | 2022 | β |
| A convenient approach to synthesize substituted 5-Arylidene-3-m-tolyl thiazolidine-2, 4-diones by using morpholine as a catalyst and its theoretical study. | Jahan K et al. | β | 2021 | β |
| Association between <i>PPAR-Ξ³2</i> gene polymorphisms and diabetic retinopathy risk: a meta-analysis. | Li XF et al. | β | 2021 | β |
| Astragaloside IV promotes microglia/macrophages M2 polarization and enhances neurogenesis and angiogenesis through PPARΞ³ pathway after cerebral ischemia/reperfusion injury in rats. | Li L et al. | β | 2021 | β |
| Cannabinoid Receptors Overexpression in a Rat Model of Irritable Bowel Syndrome (IBS) after Treatment with a Ketogenic Diet. | Gigante I et al. | β | 2021 | β |
| Gu-Ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission. | You YN et al. | β | 2021 | β |
| IFN-Ξ³ and PPARΞ΄ influence the efficacy and retention of multipotent adult progenitor cells in graft vs host disease. | Carty F et al. | β | 2021 | β |
| Inflammation and reproductive function in women with polycystic ovary syndromeβ . | Velez LM et al. | β | 2021 | β |
| Ionizing radiation-induced risks to the central nervous system and countermeasures in cellular and rodent models. | Pariset E et al. | β | 2021 | β |
| Isomer-Specific Effects of <i>cis</i>-9,<i>trans</i>-11- and <i>trans</i>-10,<i>cis</i>-12-CLA on Immune Regulation in Ruminal Epithelial Cells. | Yang C et al. | β | 2021 | β |
| Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque. | Song JW et al. | β | 2021 | β |
| Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases. | Sarandi E et al. | β | 2021 | β |
| Neurodegeneration in Multiple Sclerosis: Symptoms of Silent Progression, Biomarkers and Neuroprotective Therapy-Kynurenines Are Important Players. | Sandi D et al. | β | 2021 | β |
| Nitro-oleic acid-mediated blood-brain barrier protection reduces ischemic brain injury. | Zhou C et al. | β | 2021 | β |
| Noise-Induced Cochlear Damage Involves PPAR Down-Regulation through the Interplay between Oxidative Stress and Inflammation. | Paciello F et al. | β | 2021 | β |
| PFAS and Potential Adverse Effects on Bone and Adipose Tissue Through Interactions With PPARΞ³. | Kirk AB et al. | β | 2021 | β |
| Pharmacology of Natural Volatiles and Essential Oils in Food, Therapy, and Disease Prophylaxis. | Sadgrove NJ et al. | β | 2021 | β |
| Physiological and transcriptional analysis of Chinese soft-shelled turtle (Pelodiscus sinensis) in response to acute nitrite stress. | Feng R et al. | β | 2021 | β |
| Pioglitazone Attenuates Lupus Nephritis Symptoms in Mice by Modulating miR-21-5p/TIMP3 Axis: the Key Role of the Activation of Peroxisome Proliferator-Activated Receptor-Ξ³. | Liu D et al. | β | 2021 | β |
| PPAR agonists as effective adjuvants for COVID-19 vaccines, by modifying immunogenetics: a review of literature. | AbdelMassih AF et al. | β | 2021 | β |
| PPARΞ± Modulation-Based Therapy in Central Nervous System Diseases. | Lee D et al. | β | 2021 | β |
| PPARΞ³ agonists promote the resolution of myelofibrosis in preclinical models. | Lambert J et al. | β | 2021 | β |
| PPARΞ³ enhances ILC2 function during allergic airway inflammation via transcription regulation of ST2. | Xiao Q et al. | β | 2021 | β |
| Pregnancy Induces an Immunological Memory Characterized by Maternal Immune Alterations Through Specific Genes Methylation. | Huang X et al. | β | 2021 | β |
| Repurposing Small Molecules to Target PPAR-Ξ³ as New Therapies for Peripheral Nerve Injuries. | Rayner MLD et al. | β | 2021 | β |
| Role of Phytoconstituents as PPAR Agonists: Implications for Neurodegenerative Disorders. | Sanjay et al. | β | 2021 | β |
| Rosiglitazone alleviates lipopolysaccharide-induced inflammation in RAW264.7 cells via inhibition of NF-ΞΊB and in a PPARΞ³-dependent manner. | Zhou JP et al. | β | 2021 | β |
| Sulfur-containing therapeutics in the treatment of Alzheimer's disease. | Zhu H et al. | β | 2021 | β |
| Tackling of Renal Carcinogenesis in Wistar Rats by <i>Silybum marianum</i> Total Extract, Silymarin, and Silibinin <i>via</i> Modulation of Oxidative Stress, Apoptosis, Nrf2, PPAR<i>Ξ³</i>, NF-<i>ΞΊ</i>B, and PI3K/Akt Signaling Pathways. | Yassin NYS et al. | β | 2021 | β |
| The Endocannabinoid System and PPARs: Focus on Their Signalling Crosstalk, Action and Transcriptional Regulation. | Iannotti FA et al. | β | 2021 | β |
| The Role of PPAR Alpha in the Modulation of Innate Immunity. | Grabacka M et al. | β | 2021 | β |
| Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species. | Boraschi D et al. | β | 2020 | β |
| Associations of Ξ±- and Ξ³-tocopherol during early life with lung function in childhood. | Kumar R et al. | β | 2020 | β |
| CannabinEYEds: The Endocannabinoid System as a Regulator of the Ocular Surface Nociception, Inflammatory Response, Neovascularization and Wound Healing. | Aiello F et al. | β | 2020 | β |
| Conjugated Linoleic Acid and Brain Metabolism: A Possible Anti-Neuroinflammatory Role Mediated by PPARΞ± Activation. | Murru E et al. | β | 2020 | β |
| Effects of Pharmacologically Targeting Neuroimmune Pathways on Alcohol Drinking in Mice Selectively Bred to Drink to Intoxication. | Ozburn AR et al. | β | 2020 | β |
| Exposure to perfluoroalkyl substances and allergic outcomes in children: A systematic review and meta-analysis. | Luo Y et al. | β | 2020 | β |
| FABP7 upregulation induces a neurotoxic phenotype in astrocytes. | Killoy KM et al. | β | 2020 | β |
| FK506 binding proteins and inflammation related signalling pathways; basic biology, current status and future prospects for pharmacological intervention. | Annett S et al. | β | 2020 | β |
| Functional analysis of Epinephelus coioides peroxisome proliferative-activated receptor Ξ± (PPARΞ±): Involvement in response to viral infection. | Yang M et al. | β | 2020 | β |
| Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis. | Rajavel A et al. | β | 2020 | β |
| Metabolic factors contribute to T-cell inhibition in the ovarian cancer ascites. | Gong Y et al. | β | 2020 | β |
| Microbiota-dependent and -independent effects of dietary fibre on human health. | Cai Y et al. | β | 2020 | β |
| Minutes of PPAR-Ξ³ agonism and neuroprotection. | Prashantha Kumar BR et al. | β | 2020 | β |
| Netrin-1: Focus on its role in cardiovascular physiology and atherosclerosis. | Claro V et al. | β | 2020 | β |
| Pharmacological approaches to mitigate neuroinflammation in Alzheimer's disease. | Uddin MS et al. | β | 2020 | β |
| Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de <i>novo</i> Infection. | Planas D et al. | β | 2020 | β |
| Physical Exercise as Kynurenine Pathway Modulator in Chronic Diseases: Implications for Immune and Energy Homeostasis. | Joisten N et al. | β | 2020 | β |
| PPARΞ³ activation by pioglitazone does not suppress cravings for alcohol, and is associated with a risk of myopathy in treatment seeking alcohol dependent patients: a randomized controlled proof of principle study. | Schwandt ML et al. | β | 2020 | β |
| Risk to human health related to the presence of perfluoroalkyl substances in food. | EFSA PanelΒ on Contaminants in the Food Chain (EFSA CONTAM Panel) et al. | β | 2020 | β |
| Role of dendritic cell metabolic reprogramming in tumor immune evasion. | Plebanek MP et al. | β | 2020 | β |
| Targeting PPAR ligands as possible approaches for metabolic reprogramming of T cells in cancer immunotherapy. | Bahrambeigi S et al. | β | 2020 | β |
| The Metabolic Remodelling in Lung Cancer and Its Putative Consequence in Therapy Response. | HipΓ³lito A et al. | β | 2020 | β |
| Transcriptional Remodeling Patterns in Murine Dendritic Cells Infected with <i>Paracoccidioides brasiliensis</i>: More Is Not Necessarily Better. | de-Souza-Silva CM et al. | β | 2020 | β |
| Transcriptomic Analyses Reveal the Protective Immune Regulation of Conjugated Linoleic Acids in Sheep Ruminal Epithelial Cells. | Yang C et al. | β | 2020 | β |
| Ubiquitination of PPAR-gamma by pVHL inhibits ACLY expression and lipid metabolism, is implicated in tumor progression. | Noh KH et al. | β | 2020 | β |
| UPR modulation of host immunity by Pseudomonas aeruginosa in cystic fibrosis. | Bedi B et al. | β | 2020 | β |
| A Molecular Dynamics Approach to Explore the Intramolecular Signal Transduction of PPAR-Ξ±. | Basith S et al. | β | 2019 | β |
| B-cell-specific-peroxisome proliferator-activated receptor Ξ³ deficiency augments contact hypersensitivity with impaired regulatory B cells. | Su J et al. | β | 2019 | β |
| Composition and Potential Health Benefits of Pomegranate: A Review. | VuΔiΔ V et al. | β | 2019 | β |
| Emodin ameliorates metabolic and antioxidant capacity inhibited by dietary oxidized fish oil through PPARs and Nrf2-Keap1 signaling in Wuchang bream (Megalobrama amblycephala). | Song C et al. | β | 2019 | β |
| ER stress in skeletal muscle remodeling and myopathies. | Afroze D et al. | β | 2019 | β |
| Exenatide Reverts the High-Fat-Diet-Induced Impairment of BDNF Signaling and Inflammatory Response in an Animal Model of Alzheimer's Disease. | Bomba M et al. | β | 2019 | β |
| Exploiting the Therapeutic Potential of Endogenous Immunomodulatory Systems in Multiple Sclerosis-Special Focus on the Peroxisome Proliferator-Activated Receptors (PPARs) and the Kynurenines. | Fakan B et al. | β | 2019 | β |
| Fatty acid suppression of glial activation prevents central neuropathic pain after spinal cord injury. | Georgieva M et al. | β | 2019 | β |
| Group 1 innate lymphoid cells are involved in the progression of experimental anti-glomerular basement membrane glomerulonephritis and are regulated by peroxisome proliferator-activated receptor Ξ±. | Okabayashi Y et al. | β | 2019 | β |
| Immunoresolvents in asthma and allergic diseases: Review and update. | Lotfi R et al. | β | 2019 | β |
| Involvement of TLR4 and PPAR-Ξ± Receptors in Host Response and NLRP3 Inflammasome Activation, Against Pulmonary Infection With Pseudomonas Aeruginosa. | Gugliandolo E et al. | β | 2019 | β |
| Multiple Pathways Involved in Palmitic Acid-Induced Toxicity: A System Biology Approach. | Osorio D et al. | β | 2019 | β |
| Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies. | Kohno M et al. | β | 2019 | β |
| Neuroprotective effects of oleic acid in rodent models of cerebral ischaemia. | Song J et al. | β | 2019 | β |
| Novel Treatment Opportunities Against Cognitive Impairment in Parkinson's Disease with an Emphasis on Diabetes-Related Pathways. | Green H et al. | β | 2019 | β |
| Omega-3 fatty acid-derived mediators that control inflammation and tissue homeostasis. | Ishihara T et al. | β | 2019 | β |
| Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer's Disease. | Beggiato S et al. | β | 2019 | β |
| Pharmacological Treatment of Chemotherapy-Induced Neuropathic Pain: PPARΞ³ Agonists as a Promising Tool. | QuintΓ£o NLM et al. | β | 2019 | β |
| PPAR and GST polymorphisms may predict changes in intellectual functioning in medulloblastoma survivors. | Oyefiade A et al. | β | 2019 | β |
| PPARΞ± activation enhances the ability of nile tilapia (Oreochromis niloticus) to resist Aeromonas hydrophila infection. | Luo Y et al. | β | 2019 | β |
| Prospective of managing impaired brain insulin signalling in late onset Alzheimers disease with excisting diabetic drugs. | Jojo GM et al. | β | 2019 | β |
| Role of palmitoylethanolamide (PEA) in depression: Translational evidence: Special Section on "Translational and Neuroscience Studies in Affective Disorders". Section Editor, Maria Nobile MD, PhD. This Section of JAD focuses on the relevance of translational and neuroscience studies in providing a better understanding of the neural basis of affective disorders. The main aim is to briefly summaries relevant research findings in clinical neuroscience with particular regards to specific innovative topics in mood and anxiety disorders. | De Gregorio D et al. | β | 2019 | β |
| Scope of new formulation approaches in the repurposing of pioglitazone for the management of Alzheimer's disease. | Jojo GM et al. | β | 2019 | β |
| Synthesis and biological evaluation of thiazolidine-2,4-dione-pyrazole conjugates as antidiabetic, anti-inflammatory and antioxidant agents. | Bansal G et al. | β | 2019 | β |
| Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer's Disease: Mechanisms, Drug Candidates, and New Opportunities. | Fu WY et al. | β | 2019 | β |
| Tetramethylpyrazine guards against cisplatin-induced nephrotoxicity in rats through inhibiting HMGB1/TLR4/NF-ΞΊB and activating Nrf2 and PPAR-Ξ³ signaling pathways. | Michel HE et al. | β | 2019 | β |
| Transcriptomics analysis reveals candidate genes and pathways for susceptibility or resistance to Singapore grouper iridovirus in orange-spotted grouper (Epinephelus coioides). | Yang M et al. | β | 2019 | β |
| Airway Epithelial Cell Peroxisome Proliferator-Activated Receptor Ξ³ Regulates Inflammation and Mucin Expression in Allergic Airway Disease. | Lakshmi SP et al. | β | 2018 | β |
| Atorvastatin Inhibits the HIF1Ξ±-PPAR Axis, Which Is Essential for Maintaining the Function of Human Induced Pluripotent Stem Cells. | Nakashima Y et al. | β | 2018 | β |
| Cellular proteostasis: a new twist in the action of thymosin Ξ±1. | Stincardini C et al. | β | 2018 | β |
| Cigarette Smoke-Induced Pulmonary Inflammation Becomes Systemic by Circulating Extracellular Vesicles Containing Wnt5a and Inflammatory Cytokines. | Feller D et al. | β | 2018 | β |
| Critical role of OX40 in the expansion and survival of CD4 T-cell-derived double-negative T cells. | Sun G et al. | β | 2018 | β |
| Differentially expressed genes in PPARΞ³-deficient MSCs. | Su Y et al. | β | 2018 | β |
| Effect of Dietary Fiber and Metabolites on Mast Cell Activation and Mast Cell-Associated Diseases. | Folkerts J et al. | β | 2018 | β |
| Effects of the food additives sodium acid pyrophosphate, sodium acetate, and citric acid on hemato-immunological pathological biomarkers in rats: Relation to PPAR-Ξ±, PPAR-Ξ³ and tnfΞ± signaling pathway. | Abd-Elhakim YM et al. | β | 2018 | β |
| Emerging roles of ER stress and unfolded protein response pathways in skeletal muscle health and disease. | Bohnert KR et al. | β | 2018 | β |
| Emerging Therapeutic Role of PPAR-Ξ± in Cognition and Emotions. | Nisbett KE et al. | β | 2018 | β |
| Engineering Mammalian Designer Cells for the Treatment of Metabolic Diseases. | Wang Y et al. | β | 2018 | β |
| Fecal microbiota transplantation confers beneficial metabolic effects of diet and exercise on diet-induced obese mice. | Lai ZL et al. | β | 2018 | β |
| GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis. | Ranganathan P et al. | β | 2018 | β |
| Hints on ATGL implications in cancer: beyond bioenergetic clues. | Vegliante R et al. | β | 2018 | β |
| Identification and Molecular Characterization of Peroxisome Proliferator-Activated Receptor Ξ΄ as a Novel Target for Covalent Modification by 15-Deoxy-Ξ<sup>12,14</sup>-prostaglandin J<sub>2</sub>. | Reddy AT et al. | β | 2018 | β |
| Identification of key genes fluctuated induced by avian leukemia virus (ALV-J) infection in chicken cells. | Chen G et al. | β | 2018 | β |
| Metabolic Dysfunction and Peroxisome Proliferator-Activated Receptors (PPAR) in Multiple Sclerosis. | Ferret-Sena V et al. | β | 2018 | β |
| Microglia and alcohol meet at the crossroads: Microglia as critical modulators of alcohol neurotoxicity. | Henriques JF et al. | β | 2018 | β |
| Milk lipid regulation at the maternal-offspring interface. | Yang D et al. | β | 2018 | β |
| Nuciferine Inhibits Proinflammatory Cytokines via the PPARs in LPS-Induced RAW264.7 Cells. | Zhang C et al. | β | 2018 | β |
| Palmitoleic Acid has Stronger Anti-Inflammatory Potential in Human Endothelial Cells Compared to Oleic and Palmitic Acids. | de Souza CO et al. | β | 2018 | β |
| Palmitoylethanolamide as adjunctive therapy in major depressive disorder: A double-blind, randomized and placebo-controlled trial. | Ghazizadeh-Hashemi M et al. | β | 2018 | β |
| Polarization of Microglia to the M2 Phenotype in a Peroxisome Proliferator-Activated Receptor Gamma-Dependent Manner Attenuates Axonal Injury Induced by Traumatic Brain Injury in Mice. | Wen L et al. | β | 2018 | β |
| PPAR<i>Ξ±</i> Regulates the Proliferation of Human Glioma Cells through miR-214 and E2F2. | Gao Y et al. | β | 2018 | β |
| PPARs: Key Regulators of Airway Inflammation and Potential Therapeutic Targets in Asthma. | Banno A et al. | β | 2018 | β |
| Protective roles of fenofibrate against cisplatin-induced ototoxicity by the rescue of peroxisomal and mitochondrial dysfunction. | Kim SJ et al. | β | 2018 | β |
| Relationship between diabetes and respiratory diseases-Clinical and therapeutic aspects. | Visca D et al. | β | 2018 | β |
| Reprogramming energetic metabolism in Alzheimer's disease. | VallΓ©e A et al. | β | 2018 | β |
| Synergy between peroxisome proliferator-activated receptor Ξ³ agonist and radiotherapy in cancer. | Huang G et al. | β | 2018 | β |
| The Lipid Side of Bone Marrow Adipocytes: How Tumor Cells Adapt and Survive in Bone. | Diedrich JD et al. | β | 2018 | β |
| Therapeutic Strategies Under Development Targeting Inflammatory Mechanisms in Amyotrophic Lateral Sclerosis. | Crisafulli SG et al. | β | 2018 | β |
| Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway-PPAR Gamma, Energy Metabolism and Circadian Rhythms. | VallΓ©e A et al. | β | 2018 | β |
| The Role of PPAR-Ξ΄ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor. | Liu Y et al. | β | 2018 | β |
| The roles of PPARs in human diseases. | Li J et al. | β | 2018 | β |
| Thrombospondin-1 interactions regulate eicosanoid metabolism and signaling in cancer-related inflammation. | Ramirez MU et al. | β | 2018 | β |
| 21st Nantes ActualitΓ©s Transplantation: "When Stem Cells Meet Immunology". | Anegon I et al. | β | 2017 | β |
| Antihypertensive effects of peroxisome proliferator-activated receptor-Ξ²/Ξ΄ activation. | Toral M et al. | β | 2017 | β |
| Anti-Inflammatory and Neuroprotective Effects of Co-UltraPEALut in a Mouse Model of Vascular Dementia. | Siracusa R et al. | β | 2017 | β |
| A Review of the Molecular Mechanisms Underlying the Development and Progression of Cardiac Remodeling. | Schirone L et al. | β | 2017 | β |
| Clinical Proteomics and Cytokine Profiling for Dengue Fever Disease Severity Biomarkers. | Jadhav M et al. | β | 2017 | β |
| Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features. | Yadav S et al. | β | 2017 | β |
| DHA blocks TPA-induced cell invasion by inhibiting MMP-9 expression via suppression of the PPAR-Ξ³/NF-ΞΊB pathway in MCF-7 cells. | Hwang JK et al. | β | 2017 | β |
| Dietary supplementation with long-chain monounsaturated fatty acid isomers decreases atherosclerosis and alters lipoprotein proteomes in LDLr<sup>-/-</sup> mice. | Yang ZH et al. | β | 2017 | β |
| Docosahexaenoic acid attenuates LPS-stimulated inflammatory response by regulating the PPARΞ³/NF-ΞΊB pathways in primary bovine mammary epithelial cells. | He X et al. | β | 2017 | β |
| Effect of an acute moderate-exercise session on metabolic and inflammatory profile of PPAR-Ξ± knockout mice. | Silveira LS et al. | β | 2017 | β |
| Effects of cannabidiol interactions with Wnt/Ξ²-catenin pathway and PPARΞ³ on oxidative stress and neuroinflammation in Alzheimer's disease. | VallΓ©e A et al. | β | 2017 | β |
| Fine-mapping host genetic variation underlying outcomes to Mycobacterium bovis infection in dairy cows. | Wilkinson S et al. | β | 2017 | β |
| Ginsenoside Rg1 attenuates adjuvant-induced arthritis in rats via modulation of PPAR-Ξ³/NF-ΞΊB signal pathway. | Zhang L et al. | β | 2017 | β |
| Increased peroxisome proliferator-activated receptor Ξ³ activity reduces imatinib uptake and efficacy in chronic myeloid leukemia mononuclear cells. | Wang J et al. | β | 2017 | β |
| Inflammatory gene expression in whole blood cells after EPA vs. DHA supplementation: Results from the ComparED study. | Vors C et al. | β | 2017 | β |
| Madecassic acid, the contributor to the anti-colitis effect of madecassoside, enhances the shift of Th17 toward Treg cells via the PPARΞ³/AMPK/ACC1 pathway. | Xu X et al. | β | 2017 | β |
| Mesenchymal Stem Cell Soluble Mediators and Cystic Fibrosis. | Sutton MT et al. | β | 2017 | β |
| Metabolomics analysis identifies different metabotypes of asthma severity. | Reinke SN et al. | β | 2017 | β |
| Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARΞ³ Agonists and their Antidiabetic Effects on Type 2 Diabetes. | Yasmin S et al. | β | 2017 | β |
| P17, an Original Host Defense Peptide from Ant Venom, Promotes Antifungal Activities of Macrophages through the Induction of C-Type Lectin Receptors Dependent on LTB4-Mediated PPARΞ³ Activation. | Benmoussa K et al. | β | 2017 | β |
| Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPARΞ±-Dependent AMPK Activation. | de Souza CO et al. | β | 2017 | β |
| Palmitoleic acid reduces the inflammation in LPS-stimulated macrophages by inhibition of NFΞΊB, independently of PPARs. | Souza CO et al. | β | 2017 | β |
| Peripheral leukocyte and endometrium molecular biomarkers of inflammation and oxidative stress are altered in peripartal dairy cows supplemented with Zn, Mn, and Cu from amino acid complexes and Co from Co glucoheptonate. | Batistel F et al. | β | 2017 | β |
| Peroxisome proliferator-activated receptor-Ξ³ agonists attenuate biofilm formation by <i>Pseudomonas aeruginosa</i>. | Bedi B et al. | β | 2017 | β |
| Pharmacological evidence for systemic and peripheral antinociceptive activities of pioglitazone in the rat formalin test: Role of PPARΞ³ and nitric oxide. | Mansouri MT et al. | β | 2017 | β |
| Physiological characterization of a novel PPAR pan agonist, 2-(4-(5,6-methylenedioxybenzo[d]thiazol-2-yl)-2-methylphenoxy)-2-methylpropanoic acid (MHY2013). | An HJ et al. | β | 2017 | β |
| PPAR Agonists for the Prevention and Treatment of Lung Cancer. | Lakshmi SP et al. | β | 2017 | β |
| PPARΞ²/Ξ΄: A master regulator of mesenchymal stem cell functions. | Djouad F et al. | β | 2017 | β |
| PPARΞ³ attenuates hypoxia-induced hypertrophic transcriptional pathways in the heart. | Chaudhry A et al. | β | 2017 | β |
| Protection against alcohol-induced neuronal and cognitive damage by the PPARΞ³ receptor agonist pioglitazone. | Cippitelli A et al. | β | 2017 | β |
| Sex-specific regulation of immune responses by PPARs. | Park HJ et al. | β | 2017 | β |
| Simvastatin ameliorates memory impairment and neurotoxicity in streptozotocin-induced diabetic mice. | Fang SC et al. | β | 2017 | β |
| Spontaneous ultra-weak photon emission in correlation to inflammatory metabolism and oxidative stress in a mouse model of collagen-induced arthritis. | He M et al. | β | 2017 | β |
| The peroxisome proliferator-activated receptor pan-agonist bezafibrate suppresses microvascular inflammatory responses of retinal endothelial cells and vascular endothelial growth factor production in retinal pigmented epithelial cells. | Usui-Ouchi A et al. | β | 2017 | β |
| The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations. | Petrosino S et al. | β | 2017 | β |
| The Role of Nuclear Hormone Receptors in Cannabinoid Function. | Pistis M et al. | β | 2017 | β |
| Trans Fatty Acids Suppress TNF-Ξ±-Induced Inflammatory Gene Expression in Endothelial (HUVEC) and Hepatocellular Carcinoma (HepG2) Cells. | Da Silva MS et al. | β | 2017 | β |
| Unlike PPARgamma, neither other PPARs nor PGC-1alpha is elevated in the cerebrospinal fluid of patients with multiple sclerosis. | Szalardy L et al. | β | 2017 | β |
| Xenobiotics and the Glucocorticoid Receptor. | Gulliver LS | β | 2017 | β |
| Altered lipoproteins in patients with systemic lupus erythematosus are associated with augmented oxidative stress: a potential role in atherosclerosis. | Park JK et al. | β | 2016 | β |
| Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and Gamma. | VallΓ©e A et al. | β | 2016 | β |
| An Overlook to the Characteristics and Roles Played by Eotaxin Network in the Pathophysiology of Food Allergies: Allergic Asthma and Atopic Dermatitis. | Ahmadi Z et al. | β | 2016 | β |
| A systematic review of genetic variants associated with metabolic syndrome in patients with schizophrenia. | Malan-MΓΌller S et al. | β | 2016 | β |
| Bidirectional Expression of Metabolic, Structural, and Immune Pathways in Early Myopia and Hyperopia. | Riddell N et al. | β | 2016 | β |
| CYP1A1 mediates the suppression of major inflammatory cytokines in pulmonary alveolar macrophage (PAM) cell lines caused by Mycoplasma hyponeumoniae. | Fang X et al. | β | 2016 | β |
| Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARΞ³ directs early activation of T cells. | Angela M et al. | β | 2016 | β |
| Fatty old hearts: role of cardiac lipotoxicity in age-related cardiomyopathy. | Drosatos K | β | 2016 | β |
| Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration. | Herrera MI et al. | β | 2016 | β |
| Homeostatic PPARΞ± Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine. | Manoharan I et al. | β | 2016 | β |
| In Vivo Therapeutic Success of MicroRNA-155 Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage. | Zhou S et al. | β | 2016 | β |
| Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics. | McKinnon BD et al. | β | 2016 | β |
| Localization of PPAR isotypes in the adult mouse and human brain. | Warden A et al. | β | 2016 | β |
| Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression. | Contreras RA et al. | β | 2016 | β |
| Nanoparticles prolong N-palmitoylethanolamide anti-inflammatory and analgesic effects in vivo. | Tronino D et al. | β | 2016 | β |
| Nutrigenomics, the Microbiome, and Gene-Environment Interactions: New Directions in Cardiovascular Disease Research, Prevention, and Treatment: A Scientific Statement From the American Heart Association. | Ferguson JF et al. | β | 2016 | β |
| Obeticholic acid, a synthetic bile acid agonist of the farnesoid X receptor, attenuates experimental autoimmune encephalomyelitis. | Ho PP et al. | β | 2016 | β |
| pDCs Take a Deep Breath to Fight Viruses. | Berod L et al. | β | 2016 | β |
| Peroxisome Proliferator-Activated Receptor Ξ± Protects Renal Tubular Cells from Gentamicin-Induced Apoptosis via Upregulating Na<sup>+</sup>/H<sup>+</sup> Exchanger NHE1. | Chen CH et al. | β | 2016 | β |
| PPARΞ²/Ξ΄ directs the therapeutic potential of mesenchymal stem cells in arthritis. | Luz-Crawford P et al. | β | 2016 | β |
| PPAR-Ξ³ agonist pioglitazone regulates dendritic cells immunogenicity mediated by DC-SIGN via the MAPK and NF-ΞΊB pathways. | Zhu W et al. | β | 2016 | β |
| Role of oxidized lipids in pulmonary arterial hypertension. | Sharma S et al. | β | 2016 | β |
| Role of Pleiotropic Properties of Peroxisome Proliferator-Activated Receptors in the Heart: Focus on the Nonmetabolic Effects in Cardiac Protection. | Barlaka E et al. | β | 2016 | β |
| Sex-Based Selectivity of PPARΞ³ Regulation in Th1, Th2, and Th17 Differentiation. | Park HJ et al. | β | 2016 | β |
| Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode. | Capelli D et al. | β | 2016 | β |
| The Impact of Intramammary Escherichia coli Challenge on Liver and Mammary Transcriptome and Cross-Talk in Dairy Cows during Early Lactation Using RNAseq. | Moyes KM et al. | β | 2016 | β |
| The Inflammation Response to DEHP through PPARΞ³ in Endometrial Cells. | Huang Q et al. | β | 2016 | β |
| Therapeutic Treatment of Arthritic Mice with 15-Deoxy Ξ<sup>12,14</sup>-Prostaglandin J<sub>2</sub> (15d-PGJ<sub>2</sub>) Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4<sup>+</sup>CD25<sup>-</sup>FOXP3<sup>+</sup> Cells. | Carregaro V et al. | β | 2016 | β |
| Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection. | He JJ et al. | β | 2016 | β |
| Translational Insights Into Peroxisome Proliferator-Activated Receptors in Experimental Acute Pancreatitis. | Huang W et al. | β | 2016 | β |
| Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties. | Deiana V et al. | β | 2016 | β |
| Trimetazidine prevents macrophage-mediated septic myocardial dysfunction via activation of the histone deacetylase sirtuin 1. | Chen J et al. | β | 2016 | β |
| Activation of the peroxisome proliferator-activated receptor Ξ³ counteracts sepsis-induced T cell cytotoxicity toward alloantigenic target cells. | von Knethen A et al. | β | 2015 | β |
| Airway epithelial cell PPARΞ³ modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice. | Solleti SK et al. | β | 2015 | β |
| A single dose of PPARΞ³ agonist pioglitazone reduces cortical oxidative damage and microglial reaction following lateral fluid percussion brain injury in rats. | PilipoviΔ K et al. | β | 2015 | β |
| Chemical and protein structural basis for biological crosstalk between PPARΞ± and COX enzymes. | Cleves AE et al. | β | 2015 | β |
| Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma. | He M et al. | β | 2015 | β |
| Cytomegalovirus Infection Triggers the Secretion of the PPARΞ³ Agonists 15-Hydroxyeicosatetraenoic Acid (15-HETE) and 13-Hydroxyoctadecadienoic Acid (13-HODE) in Human Cytotrophoblasts and Placental Cultures. | Leghmar K et al. | β | 2015 | β |
| Dietary n-3 PUFA Protects Mice from Con A Induced Liver Injury by Modulating Regulatory T Cells and PPAR-Ξ³ Expression. | Lian M et al. | β | 2015 | β |
| Effect of peroxisome proliferator-activated receptor Ξ³ on inflammatory markers. | Khazaei M | β | 2015 | β |
| Endocannabinoids in synaptic plasticity and neuroprotection. | Xu JY et al. | β | 2015 | β |
| Evolutionary Pattern and Regulation Analysis to Support Why Diversity Functions Existed within PPAR Gene Family Members. | Zhou T et al. | β | 2015 | β |
| Impaired alveolarization and intra-uterine growth restriction in rats: a postnatal genome-wide analysis. | Zana-Taieb E et al. | β | 2015 | β |
| In vitro evaluation of the effects of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on IL-2 production in human T-cells. | Midgett K et al. | β | 2015 | β |
| In-vivo antioxidant and anti-inflammatory activity of rosiglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-Ξ³) agonists in animal model of bronchial asthma. | El-Naa MM et al. | β | 2015 | β |
| LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARΞ³ ligand synthesis. | LefΓ¨vre L et al. | β | 2015 | β |
| Milk-derived bioactive peptides inhibit human endothelial-monocyte interactions via PPAR-Ξ³ dependent regulation of NF-ΞΊB. | Marcone S et al. | β | 2015 | β |
| Molecular cloning, characterization and expression analysis of PPAR gamma in the orange-spotted grouper (Epinephelus coioides) after the Vibrio alginolyticus challenge. | Luo S et al. | β | 2015 | β |
| Novel phosphorylation of PPARΞ³ ameliorates obesity-induced adipose tissue inflammation and improves insulin sensitivity. | Choi S et al. | β | 2015 | β |
| Pan-PPAR modulation effectively protects APP/PS1 mice from amyloid deposition and cognitive deficits. | Kummer MP et al. | β | 2015 | β |
| Peroxisome proliferator-activated receptors Ξ± and Ξ³ are linked with alcohol consumption in mice and withdrawal and dependence in humans. | Blednov YA et al. | β | 2015 | β |
| Pioglitazone prevents morphine antinociceptive tolerance via ameliorating neuroinflammation in rat cerebral cortex. | Ghavimi H et al. | β | 2015 | β |
| PPARs: Protectors or Opponents of Myocardial Function? | Pol CJ et al. | β | 2015 | β |
| PPARΞ±/Ξ³ agonists and antagonists differently affect hepatic lipid metabolism, oxidative stress and inflammatory cytokine production in steatohepatitic rats. | Zhang Y et al. | β | 2015 | β |
| Protective effect of pioglitazone on morphine-induced neuroinflammation in the rat lumbar spinal cord. | Charkhpour M et al. | β | 2015 | β |
| Reduced expression of peroxisome proliferator-activated receptor alpha in BAL and blood T cells of non-lΓΆfgren's sarcoidosis patients. | Abo Al Hayja M et al. | β | 2015 | β |
| RNA-seq identifies a role for the PPARΞ²/Ξ΄ inverse agonist GSK0660 in the regulation of TNFΞ±-induced cytokine signaling in retinal endothelial cells. | Savage SR et al. | β | 2015 | β |
| Shift Work in Rats Results in Increased Inflammatory Response after Lipopolysaccharide Administration: A Role for Food Consumption. | Guerrero-Vargas NN et al. | β | 2015 | β |
| Stimulation of nuclear receptor peroxisome proliferator-activated receptor-Ξ³ limits NF-ΞΊB-dependent inflammation in mouse cystic fibrosis biliary epithelium. | Scirpo R et al. | β | 2015 | β |
| Supplementation of omega 3 fatty acids improves oxidative stress in activated BV2 microglial cell line. | Corsi L et al. | β | 2015 | β |
| The impact of diet on asthma and allergic diseases. | Julia V et al. | β | 2015 | β |
| The role of nuclear receptors in regulation of Th17/Treg biology and its implications for diseases. | Park BV et al. | β | 2015 | β |
| Adiponectin expression protects against angiotensin II-mediated inflammation and accelerated atherosclerosis. | van Stijn CM et al. | β | 2014 | β |
| AlzPlatform: an Alzheimer's disease domain-specific chemogenomics knowledgebase for polypharmacology and target identification research. | Liu H et al. | β | 2014 | β |
| Association of the PPAR-Ξ³ Gene with Altered Glucose Levels and Psychosis Profile in Schizophrenia Patients Exposed to Antipsychotics. | Liu YR et al. | β | 2014 | β |
| Astragalus membranaceus modulates Th1/2 immune balance and activates PPARΞ³ in a murine asthma model. | Chen SM et al. | β | 2014 | β |
| Effects of PPAR-Ξ³ agonist treatment on LPS-induced mastitis in rats. | Mingfeng D et al. | β | 2014 | β |
| Giardia muris infection in mice is associated with a protective interleukin 17A response and induction of peroxisome proliferator-activated receptor alpha. | Dreesen L et al. | β | 2014 | β |
| Guidance cue netrin-1 and the regulation of inflammation in acute and chronic kidney disease. | Ranganathan P et al. | β | 2014 | β |
| Molecular basis of alcoholism. | Most D et al. | β | 2014 | β |
| Mycosis fungoides: promoter hypermethylation predicts disease progression. | van Doorn R | β | 2014 | β |
| Netrin-1 attenuates cardiac ischemia reperfusion injury and generates alternatively activated macrophages. | Mao X et al. | β | 2014 | β |
| Neuroimmune pathways in alcohol consumption: evidence from behavioral and genetic studies in rodents and humans. | Robinson G et al. | β | 2014 | β |
| p38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppression. | Lu Y et al. | β | 2014 | β |
| Palmitoleic acid (n-7) attenuates the immunometabolic disturbances caused by a high-fat diet independently of PPARΞ±. | Souza CO et al. | β | 2014 | β |
| Peroxisome proliferator-activated receptor gamma agonists in the prevention and treatment of murine systemic lupus erythematosus. | Aprahamian TR et al. | β | 2014 | β |
| Pioglitazone prevents morphine antinociception tolerance and withdrawal symptoms in rats. | Ghavimi H et al. | β | 2014 | β |
| PPARΞ²/Ξ΄ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism. | SalvadΓ³ L et al. | β | 2014 | β |
| Radiobiological modifiers in clinical radiation oncology: current reality and future potential. | Allison RR | β | 2014 | β |
| Role of nuclear receptor on regulation of BDNF and neuroinflammation in hippocampus of Ξ²-amyloid animal model of Alzheimer's disease. | Prakash A et al. | β | 2014 | β |
| Ruscogenin ameliorates diabetic nephropathy by its anti-inflammatory and anti-fibrotic effects in streptozotocin-induced diabetic rat. | Lu HJ et al. | β | 2014 | β |
| Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARΞ³ agonist improves neuronal loss and early lethality. | Utreras E et al. | β | 2014 | β |
| The effects of maekmoondong-tang on cockroach extract-induced allergic asthma. | Park S et al. | β | 2014 | β |
| The PPARΞ± pathway in VΞ³9VΞ΄2 T cell anergy. | Poupot M et al. | β | 2014 | β |
| The PPARΞ³ agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. | Yan S et al. | β | 2014 | β |
| The reproductive hormone cycle of adult female American alligators from a barrier island population. | Hamlin HJ et al. | β | 2014 | β |
| Thiazolidinediones and the risk of asthma exacerbation among patients with diabetes: a cohort study. | Rinne ST et al. | β | 2014 | β |
| Transcriptome analysis on the inflammatory cell infiltration of nonalcoholic steatohepatitis in bama minipigs induced by a long-term high-fat, high-sucrose diet. | Xia J et al. | β | 2014 | β |
| Transcriptomic signatures of peroxisome proliferator-activated receptor Ξ± (PPARΞ±) in different mouse liver models identify novel aspects of its biology. | Szalowska E et al. | β | 2014 | β |
| 15-Deoxy-Ξ(12,14)-prostaglandin J2 inhibits IL-13 production in T cells via an NF-ΞΊB-dependent mechanism. | Doyle MC et al. | β | 2013 | β |
| A closed-loop synthetic gene circuit for the treatment of diet-induced obesity in mice. | RΓΆssger K et al. | β | 2013 | β |
| Alpinetin inhibits LPS-induced inflammatory mediator response by activating PPAR-Ξ³ in THP-1-derived macrophages. | Hu K et al. | β | 2013 | β |
| An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy. | Palomer X et al. | β | 2013 | β |
| Anti-inflammatory and anti-hyperlipidemic effect of Semecarpus anacardium in a high fat diet: STZ-induced type 2 diabetic rat model. | Khan HB et al. | β | 2013 | β |
| A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives. | Mauriz JL et al. | β | 2013 | β |
| Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms. | Herroon MK et al. | β | 2013 | β |
| Cell-specific PPARΞ³ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells. | MorΓ‘n-Salvador E et al. | β | 2013 | β |
| Curcumin Protects Neuron against Cerebral Ischemia-Induced Inflammation through Improving PPAR-Gamma Function. | Liu ZJ et al. | β | 2013 | β |
| Elevated levels of PPAR-gamma in the cerebrospinal fluid of patients with multiple sclerosis. | Szalardy L et al. | β | 2013 | β |
| Fenofibrate, a peroxisome proliferator-activated receptor Ξ±-agonist, blocks lipopolysaccharide-induced inflammatory pathways in mouse liver. | Won TW | β | 2013 | β |
| Fenofibrate A peroxisome proliferator activated receptor-Ξ± agonist treatment ameliorates Concanavalin A-induced hepatitis in rats. | Mohamed DI et al. | β | 2013 | β |
| Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study. | Liao SY et al. | β | 2013 | β |
| IL-1Ξ², RAGE and FABP4: targeting the dynamic trio in metabolic inflammation and related pathologies. | Hardaway AL et al. | β | 2013 | β |
| In vivo imaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice. | El-Jamal N et al. | β | 2013 | β |
| Modified lipoproteins provide lipids that modulate dendritic cell immune function. | Perrin-Cocon L et al. | β | 2013 | β |
| Netrin-1-treated macrophages protect the kidney against ischemia-reperfusion injury and suppress inflammation by inducing M2 polarization. | Ranganathan PV et al. | β | 2013 | β |
| Palmitoylethanolamide is a disease-modifying agent in peripheral neuropathy: pain relief and neuroprotection share a PPAR-alpha-mediated mechanism. | Di Cesare Mannelli L et al. | β | 2013 | β |
| Peroxisome proliferator-activated receptor targets for the treatment of metabolic diseases. | Monsalve FA et al. | β | 2013 | β |
| Peroxisome proliferator-activated receptor-Ξ³ agonist pioglitazone suppresses experimental autoimmune uveitis. | Okunuki Y et al. | β | 2013 | β |
| PPARΞ± agonist fenofibrate attenuates TNF-Ξ±-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway. | Wang W et al. | β | 2013 | β |
| PPARΞ± agonist Wy14643 suppresses cathepsin B in human endothelial cells via transcriptional, post-transcriptional and post-translational mechanisms. | Reichenbach G et al. | β | 2013 | β |
| PPARΞ³, an important gene related to lipid metabolism and immunity in Megalobrama amblycephala: cloning, characterization and transcription analysis by GeNorm. | Li S et al. | β | 2013 | β |
| Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents. | Viladomiu M et al. | β | 2013 | β |
| Prostacyclin and PPARΞ± agonists control vascular smooth muscle cell apoptosis and phenotypic switch through distinct 14-3-3 isoforms. | Chen YC et al. | β | 2013 | β |
| Redox control of inflammation in macrophages. | BrΓΌne B et al. | β | 2013 | β |
| Rosiglitazone and Gemcitabine in combination reduces immune suppression and modulates T cell populations in pancreatic cancer. | Bunt SK et al. | β | 2013 | β |
| Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice. | Subaiea GM et al. | β | 2013 | β |
| Strategies for optimizing the response of cancer and normal tissues to radiation. | Moding EJ et al. | β | 2013 | β |
| Synthesis of new N-substituted 5-arylidene-2,4-thiazolidinediones as anti-inflammatory and antimicrobial agents. | NastasΔ C et al. | β | 2013 | β |
| Targeting the Intracellular Environment in Cystic Fibrosis: Restoring Autophagy as a Novel Strategy to Circumvent the CFTR Defect. | Villella VR et al. | β | 2013 | β |
| 12/15-lipoxygenase during the regulation of inflammation, immunity, and self-tolerance. | Uderhardt S et al. | β | 2012 | β |
| Alteration of neuropathic and visceral pain in female C57BL/6J mice lacking the PPAR-Ξ± gene. | Ruiz-Medina J et al. | β | 2012 | β |
| Atorvastatin may delay cardiac aging by upregulating peroxisome proliferator-activated receptors in rats. | Han L et al. | β | 2012 | β |
| Beta-eleostearic acid induce apoptosis in T24 human bladder cancer cells through reactive oxygen species (ROS)-mediated pathway. | Sun Z et al. | β | 2012 | β |
| Ciglitazone inhibits cigarette smoke solution-induced inflammatory responses in human middle ear epithelial cells. | Jun HJ et al. | β | 2012 | β |
| Department of Veterans Affairs Geriatric Research, Education and Clinical Centers: translating aging research into clinical geriatrics. | Supiano MA et al. | β | 2012 | β |
| Effect of exogenous surfactant on phosphatidylinositol 3-kinase-Akt pathway and peroxisome proliferator activated receptor-Ξ³ during endotoxin induced acute respiratory distress syndrome. | Mittal N et al. | β | 2012 | β |
| Fenofibrate reduces mortality and precludes neurological deficits in survivors in murine model of Japanese encephalitis viral infection. | Sehgal N et al. | β | 2012 | β |
| Gamma linolenic acid exerts anti-inflammatory and anti-fibrotic effects in diabetic nephropathy. | Kim DH et al. | β | 2012 | β |
| Immunomodulatory action of dietary fish oil and targeted deletion of intestinal epithelial cell PPARΞ΄ in inflammation-induced colon carcinogenesis. | Monk JM et al. | β | 2012 | β |
| Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders. | Cai H et al. | β | 2012 | β |
| Microarray analysis of the intestinal host response in Giardia duodenalis assemblage E infected calves. | Dreesen L et al. | β | 2012 | β |
| New insights into the role of peroxisome proliferator-activated receptors in regulating the inflammatory response after tissue injury. | Neher MD et al. | β | 2012 | β |
| PPARs at the crossroads of lipid signaling and inflammation. | Wahli W et al. | β | 2012 | β |
| PPARΞ³ inhibits airway epithelial cell inflammatory response through a MUC1-dependent mechanism. | Park YS et al. | β | 2012 | β |
| Protective effects of gypenosides against fatty liver disease induced by high fat and cholesterol diet and alcohol in rats. | Qin R et al. | β | 2012 | β |
| Protective effects of kaerophyllin against liver fibrogenesis in rats. | Lee TF et al. | β | 2012 | β |
| Regulation of Matrix Remodeling by Peroxisome Proliferator-Activated Receptor-Ξ³: A Novel Link Between Metabolism and Fibrogenesis. | Wei J et al. | β | 2012 | β |
| Relevance of nuclear receptor expression in a Tchreg cell line, HOZOT: RXRΞ± and PPARΞ³ negatively regulate IFN-Ξ³ production. | Suzuki M et al. | β | 2012 | β |
| Role of transglutaminase 2 in celiac disease pathogenesis. | KlΓΆck C et al. | β | 2012 | β |
| Rosiglitazone protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity through inhibition of microglia activation. | He X et al. | β | 2012 | β |
| Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-ΞΊB, PPARΞ± and PPARΞ³ and the Respective Bioactive Compounds. | Rozema E et al. | β | 2012 | β |
| Subchronic effects of perfluorooctanesulfonate exposure on inflammation in adult male C57BL/6 mice. | Dong GH et al. | β | 2012 | β |
| Systemic analysis of PPARΞ³ in mouse macrophage populations reveals marked diversity in expression with critical roles in resolution of inflammation and airway immunity. | Gautier EL et al. | β | 2012 | β |
| Targeting PPARΞ²/Ξ΄ for the treatment of type 2 diabetes mellitus. | SalvadΓ³ L et al. | β | 2012 | β |
| The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases. | Choi JM et al. | β | 2012 | β |
| The peroxisome proliferator-activated receptor (PPAR) Ξ²/Ξ΄ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells. | Serrano-Marco L et al. | β | 2012 | β |
| The role of ribosylated-BSA in regulating PC12 cell viability. | Kuo TY et al. | β | 2012 | β |
| TNF-Ξ± inhibits PPARΞ²/Ξ΄ activity and SIRT1 expression through NF-ΞΊB in human adipocytes. | Serrano-Marco L et al. | β | 2012 | β |
| Toll-like receptors and diabetes: a therapeutic perspective. | Dasu MR et al. | β | 2012 | β |
| 20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-Ξ± in vascular smooth muscle cells. | Liang CJ et al. | β | 2011 | β |
| Activation of peroxisome proliferator-activated receptor-Ξ²/-Ξ΄ (PPAR-Ξ²/-Ξ΄) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes. | Serrano-Marco L et al. | β | 2011 | β |
| Characterization of the hepatic and splenic immune status and immunoglobulin synthesis in aged male mice lacking the peroxisome proliferator-activated receptor-alpha (PPARΞ±). | Qazi MR et al. | β | 2011 | β |
| Conjugated linoleic acid (CLA): is it time to supplement asthma therapy? | Macredmond R et al. | β | 2011 | β |
| Effects of chronic systemic treatment with peroxisome proliferator-activated receptor Ξ± activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide in adult mice. | Wang G et al. | β | 2011 | β |
| Effects of perfluorooctane sulfonate (PFOS) exposure on markers of inflammation in female B6C3F1 mice. | Mollenhauer MA et al. | β | 2011 | β |
| Genome-wide transcriptomic analysis of intestinal tissue to assess the impact of nutrition and a secondary nematode challenge in lactating rats. | Athanasiadou S et al. | β | 2011 | β |
| Impact and Therapeutic Potential of PPARs in Alzheimer's Disease. | Heneka MT et al. | β | 2011 | β |
| Inhibition of COX-2 expression by endocannabinoid 2-arachidonoylglycerol is mediated via PPAR-Ξ³. | Du H et al. | β | 2011 | β |
| Lack of IL-2 in PPAR-Ξ±-deficient mice triggers allergic contact dermatitis by affecting regulatory T cells. | Dubrac S et al. | β | 2011 | β |
| Molecular cross-regulation between PPAR-Ξ³ and other signaling pathways: implications for lung cancer therapy. | Reka AK et al. | β | 2011 | β |
| Neuroimmune pharmacology from a neuroscience perspective. | Northrop NA et al. | β | 2011 | β |
| NKG2D receptor regulates human effector T-cell cytokine production. | Barber A et al. | β | 2011 | β |
| Omega-3 fatty acids attenuate dendritic cell function via NF-ΞΊB independent of PPARΞ³. | Draper E et al. | β | 2011 | β |
| Oral pioglitazone reduces infarction volume and improves neurologic function following MCAO in rats. | Blankenship D et al. | β | 2011 | β |
| Palmitoylethanolamide effects on intraocular pressure after Nd:YAG laser iridotomy: an experimental clinical study. | Pescosolido N et al. | β | 2011 | β |
| Peroxisome proliferator-activated receptor-gamma agonist induces regulatory T cells in a murine model of allergic rhinitis. | Wang W et al. | β | 2011 | β |
| Pioglitazone attenuates mitochondrial dysfunction, cognitive impairment, cortical tissue loss, and inflammation following traumatic brain injury. | Sauerbeck A et al. | β | 2011 | β |
| Pioglitazone reduces secondary brain damage after experimental brain trauma by PPAR-Ξ³-independent mechanisms. | Thal SC et al. | β | 2011 | β |
| Potential benefits of supplementation with auraptene in cystic fibrosis. | Sahebkar A | β | 2011 | β |
| PPAR-alpha in cutaneous inflammation. | Dubrac S et al. | β | 2011 | β |
| PPARΞ²/Ξ΄ activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells. | Alvarez-Guardia D et al. | β | 2011 | β |
| PPARΞ³ expression is increased in systemic lupus erythematosus patients and represses CD40/CD40L signaling pathway. | Oxer DS et al. | β | 2011 | β |
| Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation. | Zoppi S et al. | β | 2011 | β |
| Role of gender in multiple sclerosis: clinical effects and potential molecular mechanisms. | Greer JM et al. | β | 2011 | β |
| Rosiglitazone regulates c-reactive protein-induced inflammatory responses via glucocorticoid receptor-mediated inhibition of p38 mitogen-activated protein kinase-toll-like receptor 4 signal pathway in vascular smooth muscle cells. | Liu N et al. | β | 2011 | β |
| SAMP1/YitFc mouse strain: a spontaneous model of Crohn's disease-like ileitis. | Pizarro TT et al. | β | 2011 | β |
| The peroxisome proliferator-activated receptor Ξ²/Ξ΄ (PPARΞ²/Ξ΄) agonist GW501516 prevents TNF-Ξ±-induced NF-ΞΊB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1. | Barroso E et al. | β | 2011 | β |
| Therapeutic potential of peroxisome proliferator-activated receptor Ξ³ agonist rosiglitazone in cerebral vasospasm after a rat experimental subarachnoid hemorrhage model. | Wu Y et al. | β | 2011 | β |
| Trans-10, cis-12-conjugated linoleic acid modulates NF-ΞΊB activation and TNF-Ξ± production in porcine peripheral blood mononuclear cells via a PPARΞ³-dependent pathway. | Kim DI et al. | β | 2011 | β |
| Will vitamin D supplementation ameliorate diseases characterized by chronic inflammation and fatigue? | Hoeck AD et al. | β | 2011 | β |
| 11beta-Hydroxysteroid dehydrogenase type 1 is an important regulator at the interface of obesity and inflammation. | Staab CA et al. | β | 2010 | β |
| 5-Androstene-3Ξ²,7Ξ²,17Ξ²-triol (Ξ²-AET) slows thermal injury induced osteopenia in mice: relation to aging and osteoporosis. | Malik AK et al. | β | 2010 | β |
| Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells. | Coll T et al. | β | 2010 | β |
| Anticancer actions of PPARΞ³ ligands: Current state and future perspectives in human lung cancer. | Han SW et al. | β | 2010 | β |
| Casein-kinase-II-dependent phosphorylation of PPARgamma provokes CRM1-mediated shuttling of PPARgamma from the nucleus to the cytosol. | von Knethen A et al. | β | 2010 | β |
| Effects of dietary lutein and PUFA on PPAR and RXR isomer expression in chickens during an inflammatory response. | Selvaraj RK et al. | β | 2010 | β |
| Graves' ophthalmopathy. | Bahn RS | β | 2010 | β |
| High-Dose Ibuprofen in Cystic Fibrosis. | Lands LC et al. | β | 2010 | β |
| HMG-CoA reductase inhibitors (statins) activate expression of PPARalpha/PPARgamma and ABCA1 in cultured gallbladder epithelial cells. | Lee J et al. | β | 2010 | β |
| Identification of a novel allele of peroxisome proliferator-activated receptor gamma (PPARG) and its association with resistance to Aeromonas salmonicida in Atlantic salmon (Salmo salar). | Sundvold H et al. | β | 2010 | β |
| Inhibitory effect on hepatitis B virus in vitro by a peroxisome proliferator-activated receptor-gamma ligand, rosiglitazone. | Wakui Y et al. | β | 2010 | β |
| Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa. | Luciani A et al. | β | 2010 | β |
| Neuroinflammatory processes in Alzheimer's disease. | Heneka MT et al. | β | 2010 | β |
| Novel aspects of pharmacological therapies for acute renal failure. | Kunzendorf U et al. | β | 2010 | β |
| Peroxisome proliferator-activated receptor gamma agonist rosiglitazone attenuates oxyhemoglobin-induced Toll-like receptor 4 expression in vascular smooth muscle cells. | Wu Y et al. | β | 2010 | β |
| Peroxisome-proliferator-activated receptor gamma (PPARgamma) is required for modulating endothelial inflammatory response through a nongenomic mechanism. | Cantini G et al. | β | 2010 | β |
| Peroxisome proliferator-activated receptor gamma (PPARgamma): Is the genomic activity the only answer? | Luconi M et al. | β | 2010 | β |
| Peroxisome proliferator-activated receptor (PPAR): balance for survival in parasitic infections. | Chan MM et al. | β | 2010 | β |
| Pioglitazone attenuates allergic inflammation and induces production of regulatory T lymphocytes. | Wang W et al. | β | 2010 | β |
| Potential of transglutaminase 2 as a therapeutic target. | Caccamo D et al. | β | 2010 | β |
| PPAR-gamma agonist inhibits Ang II-induced activation of dendritic cells via the MAPK and NF-kappaB pathways. | Wei-guo Z et al. | β | 2010 | β |
| PPARgamma agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells. | Ogasawara N et al. | β | 2010 | β |
| PPAR signaling pathway and cancer-related proteins are involved in celiac disease-associated tissue damage. | Simula MP et al. | β | 2010 | β |
| PPAR-Ξ³ agonist rosiglitazone protects peritoneal membrane from dialysis fluid-induced damage. | Sandoval P et al. | β | 2010 | β |
| PPARΞ³ modulated inflammatory response of human dendritic cell subsets to engulfed apoptotic neutrophils. | Majai G et al. | β | 2010 | β |
| Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression. | NΓΊΓ±ez V et al. | β | 2010 | β |
| Role of PPARs in Radiation-Induced Brain Injury. | Ramanan S et al. | β | 2010 | β |
| Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model. | Nisbet RE et al. | β | 2010 | β |
| The Role of Peroxisome Proliferator-Activated Receptor beta/delta on the Inflammatory Basis of Metabolic Disease. | Coll T et al. | β | 2010 | β |
| Thiazolidinediones inhibit TNF-alpha-mediated osteoclast differentiation of RAW264.7 macrophages and mouse bone marrow cells through downregulation of NFATc1. | Yang CR et al. | β | 2010 | β |
| Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice. | Park JK et al. | β | 2010 | β |
| Association of peroxisome proliferator-activated receptor-gamma gene polymorphisms with the development of asthma. | Oh SH et al. | β | 2009 | β |
| Autoradiographical imaging of PPARgamma agonist effects on PBR/TSPO binding in TASTPM mice. | Roberts JC et al. | β | 2009 | β |
| Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. | Fallarini S et al. | β | 2009 | β |
| Differential effects of PPARgamma activation by the oral antidiabetic agent pioglitazone in Barrett's carcinoma in vitro and in vivo. | Al-Taie OH et al. | β | 2009 | β |
| Differential transcriptional expression of PPARalpha, PPARgamma1, and PPARgamma2 in the peritoneal macrophages and T-cell subsets of non-obese diabetic mice. | Yaacob NS et al. | β | 2009 | β |
| Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons. | Pancani T et al. | β | 2009 | β |
| Effects of the PPAR-beta agonist GW501516 in an in vitro model of brain inflammation and antibody-induced demyelination. | Defaux A et al. | β | 2009 | β |
| Epstein-barr virus-induced gene-3 is expressed in human atheroma plaques. | Kempe S et al. | β | 2009 | β |
| Immune mechanisms and novel pharmacological therapies of acute kidney injury. | Bajwa A et al. | β | 2009 | β |
| Interference of alpha-alkyl-substituted pirinixic acid derivatives with neutrophil functions and signalling pathways. | Poeckel D et al. | β | 2009 | β |
| Modulation of microglial innate immunity in Alzheimer's disease by activation of peroxisome proliferator-activated receptor gamma. | Shie FS et al. | β | 2009 | β |
| Neurokinin 1 receptor isoforms and the control of innate immunity. | Tuluc F et al. | β | 2009 | β |
| Nitrated fatty acids prevent TNFalpha-stimulated inflammatory and atherogenic responses in endothelial cells. | Hwang J et al. | β | 2009 | β |
| Peripheral blood gene expression profiling in SjΓΆgren's syndrome. | Emamian ES et al. | β | 2009 | β |
| Peroxisome proliferator-activated receptor gamma overexpression and knockdown: impact on human B cell lymphoma proliferation and survival. | Garcia-Bates TM et al. | β | 2009 | β |
| PPAR and Pain. | Maeda T et al. | β | 2009 | β |
| PPARgamma inhibits NF-kappaB-dependent transcriptional activation in skeletal muscle. | Remels AH et al. | β | 2009 | β |
| PPARgamma regulates retinoic acid-mediated DC induction of Tregs. | Housley WJ et al. | β | 2009 | β |
| Preterm and infection-driven preterm labor: the role of peroxisome proliferator-activated receptors and retinoid X receptor. | Holdsworth-Carson SJ et al. | β | 2009 | β |
| Sex and gender in psychoneuroimmunology research: past, present and future. | Darnall BD et al. | β | 2009 | β |
| The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. | Maalouf M et al. | β | 2009 | β |
| The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. | Aprahamian T et al. | β | 2009 | β |
| 15-deoxy-delta12,14-prostaglandin J2 attenuates endothelial-monocyte interaction: implication for inflammatory diseases. | Prasad R et al. | β | 2008 | β |
| 15-deoxy-Delta12,14-prostaglandin J2 inhibits INF-gamma-induced JAK/STAT1 signalling pathway activation and IP-10/CXCL10 expression in mesangial cells. | Panzer U et al. | β | 2008 | β |
| A clinical trial of combined use of rosiglitazone and 5-aminosalicylate for ulcerative colitis. | Liang HL et al. | β | 2008 | β |
| Activated PPARgamma Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells. | Han SW et al. | β | 2008 | β |
| Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2. | RodrΓguez-Calvo R et al. | β | 2008 | β |
| A novel activity for substance P: stimulation of peroxisome proliferator-activated receptor-gamma protein expression in human monocytes and macrophages. | Amoruso A et al. | β | 2008 | β |
| Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis. | Koufany M et al. | β | 2008 | β |
| A Role for PPARgamma in the Regulation of Cytokines in Immune Cells and Cancer. | Yang XY et al. | β | 2008 | β |
| Brain nuclear factor kappa B is involved in the corticotropin-releasing factor-induced central activation of sympatho-adrenomedullary outflow in rats. | Okada S et al. | β | 2008 | β |
| Cationic liposomal lipids: from gene carriers to cell signaling. | Lonez C et al. | β | 2008 | β |
| Cis-9, trans-11-conjugated linoleic acid but not its precursor trans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2. | Reynolds CM et al. | β | 2008 | β |
| Comparison between single and combined treatment with candesartan and pioglitazone following transient focal ischemia in rat brain. | Schmerbach K et al. | β | 2008 | β |
| Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives. | Cipollone F et al. | β | 2008 | β |
| Duration of intralipid's suppressive effect on NK cell's functional activity. | Roussev RG et al. | β | 2008 | β |
| Endotoxin downregulates peroxisome proliferator-activated receptor-gamma via the increase in TNF-alpha release. | Zhou M et al. | β | 2008 | β |
| Feedback Control of the Arachidonate Cascade in Osteoblastic Cells by 15-deoxy-Delta-Prostaglandin J(2). | Ishino H et al. | β | 2008 | β |
| Human dendritic cell activities are modulated by the omega-3 fatty acid, docosahexaenoic acid, mainly through PPAR(gamma):RXR heterodimers: comparison with other polyunsaturated fatty acids. | Zapata-Gonzalez F et al. | β | 2008 | β |
| Immune mechanisms in thyroid eye disease. | Lehmann GM et al. | β | 2008 | β |
| NO-Donating NSAIDs, PPARdelta, and Cancer: Does PPARdelta Contribute to Colon Carcinogenesis? | Mackenzie GG et al. | β | 2008 | β |
| Nuclear receptors and inflammatory diseases. | Wang K et al. | β | 2008 | β |
| [Pathophysiological relevance of peroxisome proliferators activated receptors (PPAR) to joint diseases - the pro and con of agonists]. | Jouzeau JY et al. | β | 2008 | β |
| Peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism, cod liver oil and risk of type 1 diabetes. | Stene LC et al. | β | 2008 | β |
| Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats. | Sun H et al. | β | 2008 | β |
| Peroxisome proliferator-activated receptor gamma and lung cancer biology: implications for therapy. | Roman J | β | 2008 | β |
| Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles. | Ray DM et al. | β | 2008 | β |
| Peroxisome proliferator-activated receptor-gamma ligand reduced tumor necrosis factor-alpha-induced interleukin-8 production and growth in endometriotic stromal cells. | Ohama Y et al. | β | 2008 | β |
| Peroxisome proliferator-activated receptors: "key" regulators of neuroinflammation after traumatic brain injury. | Stahel PF et al. | β | 2008 | β |
| Peroxisome proliferator-activated receptors mediate host cell proinflammatory responses to Pseudomonas aeruginosa autoinducer. | Jahoor A et al. | β | 2008 | β |
| Peroxisome Proliferators-Activated Receptor (PPAR) Modulators and Metabolic Disorders. | Cho MC et al. | β | 2008 | β |
| Perspectives on the pathogenesis and therapy of hemophagocytic syndrome. | Su IJ | β | 2008 | β |
| PGJ2 antagonizes NF-kappaB-induced HIV-1 LTR activation in colonic epithelial cells. | Boisvert M et al. | β | 2008 | β |
| Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt. | Xing B et al. | β | 2008 | β |
| PPARgamma agonists and coronary atherosclerosis. | Sulistio MS et al. | β | 2008 | β |
| PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease. | Landreth G et al. | β | 2008 | β |
| PPARgamma: a novel molecular target in lung disease. | Hart CM et al. | β | 2008 | β |
| PPAR-gamma, Microglial Cells, and Ocular Inflammation: New Venues for Potential Therapeutic Approaches. | Malchiodi-Albedi F et al. | β | 2008 | β |
| PPARs and the kidney in metabolic syndrome. | Ruan X et al. | β | 2008 | β |
| PPARs in Alzheimer's Disease. | Kummer MP et al. | β | 2008 | β |
| Protective properties afforded by pioglitazone against intrastriatal LPS in Sprague-Dawley rats. | Hunter RL et al. | β | 2008 | β |
| Regulation of Lymphocyte Function by PPARgamma: Relevance to Thyroid Eye Disease-Related Inflammation. | Lehmann GM et al. | β | 2008 | β |
| Role of peroxisome proliferator-activated receptor alpha in the control of cyclooxygenase 2 and vascular endothelial growth factor: involvement in tumor growth. | Grau R et al. | β | 2008 | β |
| Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons. | Brodbeck J et al. | β | 2008 | β |
| Self-reported symptoms of sleep disturbance and inflammation, coagulation, insulin resistance and psychosocial distress: evidence for gender disparity. | Suarez EC | β | 2008 | β |
| Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats. | GarcΓa-Bueno B et al. | β | 2008 | β |
| The effect of PPARalpha and PPARgamma ligands on inflammation and ABCA1 expression in cultured gallbladder epithelial cells. | Lee J et al. | β | 2008 | β |
| The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: therapeutic implications. | Jiang Q et al. | β | 2008 | β |
| The synthetic PPARgamma agonist troglitazone inhibits eotaxin-enhanced eosinophil adhesion to ICAM-1-coated plates. | Hirasawa H et al. | β | 2008 | β |
| 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells. | Altmann R et al. | β | 2007 | β |
| Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome. | Erbay E et al. | β | 2007 | β |
| Agonism of Peroxisome Proliferator Receptor-Gamma may have Therapeutic Potential for Neuroinflammation and Parkinson's Disease. | Randy LH et al. | β | 2007 | β |
| Androstenetriol immunomodulation improves survival in a severe trauma hemorrhage shock model. | Marcu AC et al. | β | 2007 | β |
| Anti- and proinflammatory effects of 15-deoxy-delta-prostaglandin J2(15d-PGJ2) on human eosinophil functions. | Ueki S et al. | β | 2007 | β |
| A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. | Nguyen MT et al. | β | 2007 | β |
| Bacteria- and host-derived mechanisms to control intestinal epithelial cell homeostasis: implications for chronic inflammation. | Clavel T et al. | β | 2007 | β |
| Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. | Kim LK et al. | β | 2007 | β |
| Drug insight: effects mediated by peroxisome proliferator-activated receptor-gamma in CNS disorders. | Heneka MT et al. | β | 2007 | β |
| Engineering skin to study human disease--tissue models for cancer biology and wound repair. | Garlick JA | β | 2007 | β |
| Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors. | KrΓΆnke G et al. | β | 2007 | β |
| Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice. | Lee JW et al. | β | 2007 | β |
| Inactivation of peroxisome proliferator-activated receptor isoforms alpha, beta/delta, and gamma mediate distinct facets of hypertrophic transformation of adult cardiac myocytes. | Pellieux C et al. | β | 2007 | β |
| Inflammatory processes in Alzheimer's disease. | Heneka MT et al. | β | 2007 | β |
| Interleukin-10 is upregulated by nanomolar rosiglitazone treatment of mature dendritic cells and human CD4+ T cells. | Thompson PW et al. | β | 2007 | β |
| Involvement of different nuclear hormone receptors in butyrate-mediated inhibition of inducible NF kappa B signalling. | Schwab M et al. | β | 2007 | β |
| Mechanism of thiazolidinedione-dependent cell death in Jurkat T cells. | Soller M et al. | β | 2007 | β |
| Pathogenesis and mechanism of disease progression from hemophagocytic lymphohistiocytosis to Epstein-Barr virus-associated T-cell lymphoma: nuclear factor-kappa B pathway as a potential therapeutic target. | Chuang HC et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptor alpha down-regulation is associated with enhanced ceramide levels in age-associated cardiac hypertrophy. | RodrΓguez-Calvo R et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptor-alpha is required for the neurotrophic effect of oleic acid in neurons. | Bento-Abreu A et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD. | Remels AH et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptor gamma activation relieves expression of behavioral sensitization to methamphetamine in mice. | Maeda T et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. | Arnold R et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptor gamma interacts with CIITA x RFX5 complex to repress type I collagen gene expression. | Xu Y et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptor gamma (PPARgamma) and immunoregulation: enhancement of regulatory T cells through PPARgamma-dependent and -independent mechanisms. | Wohlfert EA et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. | Dunn SE et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptors in lung cancer. | Keshamouni VG et al. | β | 2007 | β |
| PPAR agonists modulate human osteoclast formation and activity in vitro. | Chan BY et al. | β | 2007 | β |
| PPARbeta/delta protects against experimental colitis through a ligand-independent mechanism. | Hollingshead HE et al. | β | 2007 | β |
| PPARgamma expression profile and its cytokine driven regulation in atopic dermatitis. | Dahten A et al. | β | 2007 | β |
| PPAR-gamma receptor ligand induces regression of endometrial explants in baboons: a prospective, randomized, placebo- and drug-controlled study. | Lebovic DI et al. | β | 2007 | β |
| PPARs and molecular mechanisms of transrepression. | Ricote M et al. | β | 2007 | β |
| Pseudomonas aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARalpha-RXR. | Agassandian M et al. | β | 2007 | β |
| Punica granatum: heuristic treatment for diabetes mellitus. | Katz SR et al. | β | 2007 | β |
| Role of oxidative stress in cardiac dysfunction of PPARalpha-/- mice. | Guellich A et al. | β | 2007 | β |
| Role of PPARs and Retinoid X Receptors in the Regulation of Lung Maturation and Development. | Simon DM et al. | β | 2007 | β |
| Role of transcription factors in mediating post-ischemic cerebral inflammation and brain damage. | Yi JH et al. | β | 2007 | β |
| Rosiglitazone, a PPARgamma ligand, modulates signal transduction pathways during the development of acute TNBS-induced colitis in rats. | SΓ‘nchez-Hidalgo M et al. | β | 2007 | β |
| Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts. | Chen Y et al. | β | 2007 | β |
| The potential role of olive oil-derived MUFA in insulin sensitivity. | Tierney AC et al. | β | 2007 | β |
| The role of peroxisome proliferator-activated receptors in pulmonary vascular disease. | Nisbet RE et al. | β | 2007 | β |
| The role of PPARgamma on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction. | Ponferrada A et al. | β | 2007 | β |
| Trans-10, cis-12-conjugated linoleic acid increases phagocytosis of porcine peripheral blood polymorphonuclear cells in vitro. | Kang JH et al. | β | 2007 | β |
| Upregulation of tumor necrosis factor-alpha expression by trans10-cis12 conjugated linoleic acid enhances phagocytosis of RAW macrophages via a peroxisome proliferator-activated receptor gamma-dependent pathway. | Song DH et al. | β | 2007 | β |
| 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. | Phulwani NK et al. | β | 2006 | β |
| Altered PPARgamma expression and activation after transient focal ischemia in rats. | Victor NA et al. | β | 2006 | β |
| "Anti-inflammatory" drugs and their effects on type 2 diabetes. | Deans KA et al. | β | 2006 | β |
| Attenuation of colonic inflammation by PPARgamma in intestinal epithelial cells: effect on Toll-like receptor pathway. | Eun CS et al. | β | 2006 | β |
| Cardiomyocytic apoptosis following global cardiac ischemia and reperfusion can be attenuated by peroxisome proliferator-activated receptor alpha but not gamma activators. | Yeh CH et al. | β | 2006 | β |
| Combinatorial roles of nuclear receptors in inflammation and immunity. | Glass CK et al. | β | 2006 | β |
| Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms. | Sastre M et al. | β | 2006 | β |
| Epidermal-type fatty acid binding protein as a negative regulator of IL-12 production in dendritic cells. | Kitanaka N et al. | β | 2006 | β |
| Epithelial cell PPAR[gamma] contributes to normal lung maturation. | Simon DM et al. | β | 2006 | β |
| Human T cell cytokine responses are dependent on multidrug resistance protein-1. | Zhang J et al. | β | 2006 | β |
| Inflammation and cancer: how hot is the link? | Aggarwal BB et al. | β | 2006 | β |
| Interleukin-2 suppression by 2-arachidonyl glycerol is mediated through peroxisome proliferator-activated receptor gamma independently of cannabinoid receptors 1 and 2. | Rockwell CE et al. | β | 2006 | β |
| Intestinal epithelial cell signalling and host-derived negative regulators under chronic inflammation: to be or not to be activated determines the balance towards commensal bacteria. | Haller D | β | 2006 | β |
| Lipid-lowering drugs. | Pahan K | β | 2006 | β |
| Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. | Collino M et al. | β | 2006 | β |
| Nitrated fatty acids: Endogenous anti-inflammatory signaling mediators. | Cui T et al. | β | 2006 | β |
| Nonalcoholic fatty liver disease: Cytokine-adipokine interplay and regulation of insulin resistance. | Tilg H et al. | β | 2006 | β |
| Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes. | Blaschke F et al. | β | 2006 | β |
| Peroxisome-proliferator-activated receptor alpha agonists inhibit cyclo-oxygenase 2 and vascular endothelial growth factor transcriptional activation in human colorectal carcinoma cells via inhibition of activator protein-1. | Grau R et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor-gamma agonists as potential anti-inflammatory agents in asthma and chronic obstructive pulmonary disease. | Spears M et al. | β | 2006 | β |
| Peroxisome-proliferator-activated receptor-gamma agonists inhibit the release of proinflammatory cytokines from RSV-infected epithelial cells. | Arnold R et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor-gamma agonists inhibit the replication of respiratory syncytial virus (RSV) in human lung epithelial cells. | Arnold R et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor gamma contributes to T lymphocyte apoptosis during sepsis. | Soller M et al. | β | 2006 | β |
| Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease. | Adachi M et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands reverse CTL suppression by alternatively activated (M2) macrophages in cancer. | Van Ginderachter JA et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptors: potential therapeutic targets in lung disease? | Denning GM et al. | β | 2006 | β |
| PPARgamma agonists as new therapeutic agents for the treatment of Alzheimer's disease. | Landreth G | β | 2006 | β |
| Recognition of apoptotic cells by macrophages activates the peroxisome proliferator-activated receptor-gamma and attenuates the oxidative burst. | Johann AM et al. | β | 2006 | β |
| Rosiglitazone, a peroxisome proliferator-activated receptor-gamma ligand, reduces infarction volume and neurological deficits in an embolic model of stroke. | Allahtavakoli M et al. | β | 2006 | β |
| Significance of anti-inflammatory effects of PPARgamma agonists? | Rogler G | β | 2006 | β |
| The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. | Ray DM et al. | β | 2006 | β |
| Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease. | Rossner S et al. | β | 2006 | β |
| Up-regulated membrane and nuclear leukotriene B4 receptors in COPD. | Marian E et al. | β | 2006 | β |
| Up-regulation of peroxidase proliferator-activated receptor gamma in cholesteatoma. | Hwang SJ et al. | β | 2006 | β |
| Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity. | Berruyer C et al. | β | 2006 | β |
| 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) signals through retinoic acid receptor-related orphan receptor-alpha but not peroxisome proliferator-activated receptor-gamma in human vascular endothelial cells: the effect of 15d-PGJ2 on tumor necrosis factor-alpha-induced gene expression. | Migita H et al. | β | 2005 | β |
| Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. | Heneka MT et al. | β | 2005 | β |
| Agonist-induced activation releases peroxisome proliferator-activated receptor beta/delta from its inhibition by palmitate-induced nuclear factor-kappaB in skeletal muscle cells. | JovΓ© M et al. | β | 2005 | β |
| An inverse relationship between peroxisome proliferator-activated receptor gamma and allergic airway inflammation in an allergen challenge model. | Kobayashi M et al. | β | 2005 | β |
| Anti-inflammatory effect of fibrate protects from cisplatin-induced ARF. | Li S et al. | β | 2005 | β |
| Atorvastatin prevents peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) downregulation in lipopolysaccharide-stimulated H9c2 cells. | Planavila A et al. | β | 2005 | β |
| Bezafibrate suppresses rat antiglomerular basement membrane crescentic glomerulonephritis. | Saga D et al. | β | 2005 | β |
| Ciglitazone increases basal cytokine expression in the central nervous system of adult rats. | GΓ©linas DS et al. | β | 2005 | β |
| Conjugated linoleic acid can prevent tumor necrosis factor gene expression by inhibiting nuclear factor binding activity in peripheral blood mononuclear cells from weaned pigs challenged with lipopolysaccharide. | Zhao L et al. | β | 2005 | β |
| Dietary n-3 polyunsaturated fatty acids increase T-lymphocyte phospholipid mass and acyl-CoA binding protein expression. | Collison LW et al. | β | 2005 | β |
| Downregulation of peroxisome proliferator-activated receptors (PPARs) in nasal polyposis. | Cardell LO et al. | β | 2005 | β |
| Effects of peroxisome proliferator-activated receptor alpha/delta agonists on HDL-cholesterol in vervet monkeys. | Wallace JM et al. | β | 2005 | β |
| Epitope analysis of PPARgamma monoclonal antibody Pgamma48.34A and its application for screening PPARgamma ligands. | Lee HS et al. | β | 2005 | β |
| Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances. | Randolph GJ et al. | β | 2005 | β |
| Fungal metabolites, sorbicillinoid polyketides and their effects on the activation of peroxisome proliferator-activated receptor gamma. | Lee D et al. | β | 2005 | β |
| Inflammation, stress, and diabetes. | Wellen KE et al. | β | 2005 | β |
| Inhibition of IL-10-induced STAT3 activation by 15-deoxy-Delta12,14-prostaglandin J2. | Ji JD et al. | β | 2005 | β |
| Insulinotropic and anti-inflammatory effects of rosiglitazone in experimental autoimmune diabetes. | Awara WM et al. | β | 2005 | β |
| Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn's disease. | Sugawara K et al. | β | 2005 | β |
| Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway. | Ialenti A et al. | β | 2005 | β |
| Nanomolar and micromolar effects of 15-deoxy-delta 12,14-prostaglandin J2 on amnion-derived WISH epithelial cells: differential roles of peroxisome proliferator-activated receptors gamma and delta and nuclear factor kappa B. | Berry EB et al. | β | 2005 | β |
| Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. | Planavila A et al. | β | 2005 | β |
| Opposite effects of low and high dose supplementation of vitamin E on survival of MRL/lpr mice. | Hsieh CC et al. | β | 2005 | β |
| Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats. | GarcΓa-Bueno B et al. | β | 2005 | β |
| Peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists have minimal effects on the interaction of endothelial cells with Plasmodium falciparum-infected erythrocytes. | Serghides L et al. | β | 2005 | β |
| Peroxisome proliferator-activated receptor-gamma ligands reduce inflammation and infarction size in transient focal ischemia. | Sundararajan S et al. | β | 2005 | β |
| Peroxisome proliferator-activated receptor gamma: the more the merrier? | Argmann CA et al. | β | 2005 | β |
| Peroxisome proliferator-activated receptors and their ligands: entry into the post-glucocorticoid era of skin treatment? | Weindl G et al. | β | 2005 | β |
| Polyunsaturated fatty acids block dendritic cell activation and function independently of NF-kappaB activation. | Zeyda M et al. | β | 2005 | β |
| PPAR and Crohn's disease: another piece of the puzzle? | Hugot JP | β | 2005 | β |
| 'PPAR'ting ways with inflammation. | Bailey ST et al. | β | 2005 | β |
| Pro-inflammatory properties for thiazolidinediones. | Desmet C et al. | β | 2005 | β |
| The cyclopentenone (A2/J2) isoprostanes--unique, highly reactive products of arachidonate peroxidation. | Milne GL et al. | β | 2005 | β |
| The oral antidiabetic pioglitazone protects from neurodegeneration and amyotrophic lateral sclerosis-like symptoms in superoxide dismutase-G93A transgenic mice. | SchΓΌtz B et al. | β | 2005 | β |
| The peroxisome proliferator-activated receptor gamma ligand rosiglitazone delays the onset of inflammatory bowel disease in mice with interleukin 10 deficiency. | Lytle C et al. | β | 2005 | β |
| The role of endothelial cells in the resolution of acute inflammation. | Kadl A et al. | β | 2005 | β |
| The role of the immune system in the pathophysiology of osteoporosis. | Clowes JA et al. | β | 2005 | β |
| The search for the palmitoylethanolamide receptor. | LoVerme J et al. | β | 2005 | β |
| Unusual astrocyte reactivity caused by the food mycotoxin ochratoxin A in aggregating rat brain cell cultures. | Zurich MG et al. | β | 2005 | β |
| 15-deoxy-delta12,14-prostaglandin J2-mediated ERK signaling inhibits gram-negative bacteria-induced RelA phosphorylation and interleukin-6 gene expression in intestinal epithelial cells through modulation of protein phosphatase 2A activity. | Ruiz PA et al. | β | 2004 | β |
| 1. Peroxisome proliferator-activated receptor gamma (PPARgamma) ligands and their therapeutic utility. | Henke BR | β | 2004 | β |
| Activation of peroxisome proliferator-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma. | Hammad H et al. | β | 2004 | β |
| Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists. | Grommes C et al. | β | 2004 | β |
| Ciglitazone inhibits oxidized-low density lipoprotein induced immune maturation of dendritic cells. | Luo Y et al. | β | 2004 | β |
| Combination of a CpG-oligodeoxynucleotide and a topoisomerase I inhibitor in the therapy of human tumour xenografts. | Balsari A et al. | β | 2004 | β |
| Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice. | Huo Y et al. | β | 2004 | β |
| Diverse regulation of NF-kappaB and peroxisome proliferator-activated receptors in murine nonalcoholic fatty liver. | Romics L et al. | β | 2004 | β |
| Effects of PPARg agonist pioglitazone on rat hepatic fibrosis. | Yuan GJ et al. | β | 2004 | β |
| Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. | Akbiyik F et al. | β | 2004 | β |
| Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. | Ray DM et al. | β | 2004 | β |
| Ligand-induced expression of peroxisome proliferator-activated receptor alpha and activation of fatty acid oxidation enzymes in fatty liver. | Akbiyik F et al. | β | 2004 | β |
| Lipaemia, inflammation and atherosclerosis: novel opportunities in the understanding and treatment of atherosclerosis. | van Oostrom AJ et al. | β | 2004 | β |
| Medical lipid-regulating therapy: current evidence, ongoing trials and future developments. | Evans M et al. | β | 2004 | β |
| Metabolic reprogramming in plant innate immunity: the contributions of phenylpropanoid and oxylipin pathways. | La Camera S et al. | β | 2004 | β |
| Molecular aspects of alcohol metabolism: transcription factors involved in early ethanol-induced liver injury. | Nagy LE | β | 2004 | β |
| Nuclear prostaglandin receptors: role in pregnancy and parturition? | Helliwell RJ et al. | β | 2004 | β |
| Peroxisome proliferator-activated receptor-alpha regulates postischemic liver injury. | Okaya T et al. | β | 2004 | β |
| Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells. | Zhang X et al. | β | 2004 | β |
| Peroxisome proliferator-activated receptor-gamma down-regulates chondrocyte matrix metalloproteinase-1 via a novel composite element. | FranΓ§ois M et al. | β | 2004 | β |
| Peroxisome proliferator-activated receptor gamma: implications for cardiovascular disease. | Hsueh WA et al. | β | 2004 | β |
| Peroxisome proliferator-activated receptor gamma regulates eosinophil functions: a new therapeutic target for allergic airway inflammation. | Ueki S et al. | β | 2004 | β |
| Peroxisome proliferator-activated receptor-gamma: therapeutic target for diseases beyond diabetes: quo vadis? | Pershadsingh HA | β | 2004 | β |
| PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis. | Li AC et al. | β | 2004 | β |
| Prevention of age-related changes in rat cortex transcription factor activator protein-1 by hypolipidemic drugs. | Sanguino E et al. | β | 2004 | β |
| 15-Deoxy-delta12,14-PGJ2: endogenous PPARgamma ligand or minor eicosanoid degradation product? | Powell WS | β | 2003 | β |
| 15-deoxy-delta12,14-prostaglandin J2 regulates the functional state and the survival of microglial cells through multiple molecular mechanisms. | Bernardo A et al. | β | 2003 | β |
| CD36 and malaria: friends or foes? | Serghides L et al. | β | 2003 | β |
| Hepatic expression of PPARalpha, a molecular target of fibrates, is regulated during inflammation in a gender-specific manner. | Tai ES et al. | β | 2003 | β |
| Is there a role for PPAR gamma in IBD? Yes, no, maybe. | Wu GD | β | 2003 | β |
| Peroxisome proliferator-activated receptor-gamma is deficient in alveolar macrophages from patients with alveolar proteinosis. | Bonfield TL et al. | β | 2003 | β |
| Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation. | Woerly G et al. | β | 2003 | β |
| Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. | Beck S et al. | β | 2003 | β |
| PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages. | Welch JS et al. | β | 2003 | β |
| Preadipocyte conversion to macrophage. Evidence of plasticity. | CharriΓ¨re G et al. | β | 2003 | β |
| Resistance to high-fat diet-induced obesity and altered expression of adipose-specific genes in HSL-deficient mice. | Harada K et al. | β | 2003 | β |
| Role of redox imbalance in the molecular mechanisms responsible for immunosenescence. | Daynes RA et al. | β | 2003 | β |