Power and sample size calculations in case-control studies of gene-environment interactions: comments on different approaches.
paper
Cited
Public
Unavailable
- Authors
- GarcΓa-Closas, M; Lubin, J H
- Year
- 1999
- Journal
- American journal of epidemiology
- PMID
- 10206617
- DOI
- 10.1093/oxfordjournals.aje.a009876
Power and sample size considerations are critical for the design of epidemiologic studies of gene-environment interactions. Hwang et al. (Am J Epidemiol 1994;140:1029-37) and Foppa and Spiegelman (Am J Epidemiol 1997;146:596-604) have presented power and sample size calculations for case-control studies of gene-environment interactions. Comparisons of calculations using these approaches and an approach for general multivariate regression models for the odds ratio previously published by Lubin and Gail (Am J Epidemiol 1990; 131:552-66) have revealed substantial differences under some scenarios. These differences are the result of a highly restrictive characterization of the null hypothesis in Hwang et al. and Foppa and Spiegelman, which results in an underestimation of sample size and overestimation of power for the test of a gene-environment interaction. A computer program to perform sample size and power calculations to detect additive or multiplicative models of gene-environment interactions using the Lubin and Gail approach will be available free of charge in the near future from the National Cancer Institute.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Predictors of metabolic dysfunction-associated steatotic liver diseases (MASLD) in Vietnamese population. | Pham AG et al. | β | 2026 | β |
| A Systematic Review of the Effect of Gene-Lifestyle Interactions on Metabolic-Disease-Related Traits in South Asian Populations. | Bineid MM et al. | β | 2025 | β |
| Association of SNP-SNP interactions of surfactant protein genes with severity of respiratory syncytial virus infection in children. | Gandhi CK et al. | β | 2024 | β |
| Cox proportional hazards regression in small studies of predictive biomarkers. | JΓ³ΕΊwiak K et al. | β | 2024 | β |
| In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status. | Tan PY et al. | β | 2024 | β |
| A scoping review of statistical methods in studies of biomarker-related treatment heterogeneity for breast cancer. | Sollfrank L et al. | β | 2023 | β |
| Functional variant rs10175368 which affects the expression of CYP1B1 plays a protective role against breast cancer in a Chinese Han population. | Liu J et al. | β | 2023 | β |
| Particulate matter exposure in construction sites is associated with health effects in workers. | Sekhavati E et al. | β | 2023 | β |
| The Areola study: design and rationale of a cohort study on long-term health outcomes in women with implant-based breast reconstructions. | Spoor J et al. | β | 2023 | β |
| Cohort profile: four early uranium processing facilities in the US and Canada. | Golden AP et al. | β | 2021 | β |
| Descriptive characteristics of occupational exposures and medical follow-up in the cohort of workers of the Siberian Group of Chemical Enterprises in Seversk, Russia. | Karpov AB et al. | β | 2021 | β |
| Association of SNP-SNP Interactions of Surfactant Protein Genes with Pediatric Acute Respiratory Failure. | Gandhi CK et al. | β | 2020 | β |
| Vitamin D receptor rs2228570 polymorphism and Parkinson's disease risk in a Chinese population. | Hu W et al. | β | 2020 | β |
| Alcohol Intake Interacts with Functional Genetic Polymorphisms of Aldehyde Dehydrogenase (ALDH2) and Alcohol Dehydrogenase (ADH) to Increase Esophageal Squamous Cell Cancer Risk. | Suo C et al. | β | 2019 | β |
| Polymorphisms in CEP68 gene associated with risk of immediate selective reactions to non-steroidal anti-inflammatory drugs. | Perkins JR et al. | β | 2019 | β |
| Prenatal Tobacco Exposure Modulated the Association of Genetic variants with Diagnosed ADHD and its symptom domain in children: A Community Based Case-Control Study. | Wang Y et al. | β | 2019 | β |
| Genetics of rotator cuff tears: no association of col5a1 gene in a case-control study. | Longo UG et al. | β | 2018 | β |
| Interaction of a genetic risk score with physical activity, physical inactivity, and body mass index in relation to venous thromboembolism risk. | Kim J et al. | β | 2018 | β |
| Neurexin gene family variants as risk factors for autism spectrum disorder. | Wang J et al. | β | 2018 | β |
| Detecting Familial Aggregation. | Naj AC et al. | β | 2017 | β |
| A functional variant rs4442975 modulating FOXA1-binding affinity does not influence the risk or progression of breast cancer in Chinese Han population. | Zhang Y et al. | β | 2016 | β |
| Detecting Gene-Environment Interactions for a Quantitative Trait in a Genome-Wide Association Study. | Zhang P et al. | β | 2016 | β |
| Exposure Enriched Case-Control (EECC) Design for the Assessment of Gene-Environment Interaction. | Huque MH et al. | β | 2016 | β |
| Periconceptional seafood intake and pregnancy complications. | Mohanty AF et al. | β | 2016 | β |
| Power/sample size calculations for assessing correlates of risk in clinical efficacy trials. | Gilbert PB et al. | β | 2016 | β |
| The Roles of Genes in the Neuronal Migration and Neurite Outgrowth Network in Developmental Dyslexia: Single- and Multiple-Risk Genetic Variants. | Shao S et al. | β | 2016 | β |
| A phosphorylation-related variant ADD1-rs4963 modifies the risk of colorectal cancer. | Shen N et al. | β | 2015 | β |
| Infant sex-specific placental cadmium and DNA methylation associations. | Mohanty AF et al. | β | 2015 | β |
| Paraoxonase 2 gene polymorphisms and prenatal phthalates' exposure in Chinese newborns. | Xie C et al. | β | 2015 | β |
| Systematic confirmation study of GWAS-identified genetic variants for Kawasaki disease in a Chinese population. | Lou J et al. | β | 2015 | β |
| Associations between ABCG2 gene polymorphisms and isolated septal defects in a Han Chinese population. | Wang C et al. | β | 2014 | β |
| Biomarkers of susceptibility to chemical carcinogens: the example of non-Hodgkin lymphomas. | Kelly RS et al. | β | 2014 | β |
| Combined analysis with copy number variation identifies risk loci in lung cancer. | Li X et al. | β | 2014 | β |
| Maternal medication use, fetal 3435 C>T polymorphism of the ABCB1 gene, and risk of isolated septal defects in a Han Chinese population. | Wang C et al. | β | 2014 | β |
| Risk for suicidal behaviors associated with PTSD, depression, and their comorbidity in the U.S. Army. | Ramsawh HJ et al. | β | 2014 | β |
| The roles of Ca2+/NFAT signaling genes in Kawasaki disease: single- and multiple-risk genetic variants. | Wang W et al. | β | 2014 | β |
| Variants of CEP68 gene are associated with acute urticaria/angioedema induced by multiple non-steroidal anti-inflammatory drugs. | Cornejo-GarcΓa JA et al. | β | 2014 | β |
| Gene-environment interactions in cancer epidemiology: a National Cancer Institute Think Tank report. | Hutter CM et al. | β | 2013 | β |
| Increased risk for congenital heart defects in children carrying the ABCB1 Gene C3435T polymorphism and maternal periconceptional toxicants exposure. | Wang C et al. | β | 2013 | β |
| Detecting familial aggregation. | Naj AC et al. | β | 2012 | β |
| Effect on risk of anencephaly of gene-nutrient interactions between methylenetetrahydrofolate reductase C677T polymorphism and maternal folate, vitamin B12 and homocysteine profile. | LacasaΓ±a M et al. | β | 2012 | β |
| Enterovirus RNA in peripheral blood may be associated with the variants of rs1990760, a common type 1 diabetes associated polymorphism in IFIH1. | Cinek O et al. | β | 2012 | β |
| Genetic variant I148M in PNPLA3 is associated with the ultrasonography-determined steatosis degree in a Chinese population. | Li Y et al. | β | 2012 | β |
| Individual and combined effects of MDM2 SNP309 and TP53 Arg72Pro on breast cancer risk: an updated meta-analysis. | Cheng H et al. | β | 2012 | β |
| Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies. | Raimondi S et al. | β | 2012 | β |
| Sample Size and Power Calculations for Additive Interactions. | VanderWeele TJ | β | 2012 | β |
| Using PhenX measures to identify opportunities for cross-study analysis. | Pan H et al. | β | 2012 | β |
| A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. | Duncan LE et al. | β | 2011 | β |
| Analysis of gene-gene interactions. | Gilbert-Diamond D et al. | β | 2011 | β |
| Genetic variants on chromosome 8q24 and colorectal neoplasia risk: a case-control study in China and a meta-analysis of the published literature. | Li M et al. | β | 2011 | β |
| [Interaction between dietary intake and GSTM1 and GSTT1 polymorphisms in head and neck cancer risk: a case-control study in SΓ£o Paulo, Brazil]. | Marchioni DM et al. | β | 2011 | β |
| Phenotype harmonization and cross-study collaboration in GWAS consortia: the GENEVA experience. | Bennett SN et al. | β | 2011 | β |
| Regarding "meta-analysis and causal inference: a case study of benzene and non-Hodgkin lymphoma": an incomplete analysis. | Steinmaus C et al. | β | 2011 | β |
| Sample size and power calculations for case-only interaction studies. | VanderWeele TJ | β | 2011 | β |
| A novel approach to simulate gene-environment interactions in complex diseases. | Amato R et al. | β | 2010 | β |
| Case-control studies of gene-environment interaction: Bayesian design and analysis. | Mukherjee B et al. | β | 2010 | β |
| Effect of including environmental data in investigations of gene-disease associations in the presence of qualitative interactions. | Williamson E et al. | β | 2010 | β |
| Gene--environment-wide association studies: emerging approaches. | Thomas D | β | 2010 | β |
| No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis. | Bergamaschi L et al. | β | 2010 | β |
| Quality, quantity and harmony: the DataSHaPER approach to integrating data across bioclinical studies. | Fortier I et al. | β | 2010 | β |
| The G1359A-CNR1 gene polymorphism is associated to glioma in Spanish patients. | NΓΊΓ±ez M et al. | β | 2010 | β |
| Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study. | Chu AY et al. | β | 2009 | β |
| Bone fractures and incident epithelial ovarian cancer in a prospective cohort study. | Danforth KN et al. | β | 2009 | β |
| Detecting gene-environment interactions using a combined case-only and case-control approach. | Li D et al. | β | 2009 | β |
| Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw. | Vahtsevanos K et al. | β | 2009 | β |
| Mutual information for testing gene-environment interaction. | Wu X et al. | β | 2009 | β |
| Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population. | Grabe HJ et al. | β | 2009 | β |
| The virtues of a deliberately mis-specified disease model in demonstrating a gene-environment interaction. | Burstyn I et al. | β | 2009 | β |
| Vitamin D receptor (VDR) gene polymorphisms and Graves' disease: a meta-analysis. | Zhou H et al. | β | 2009 | β |
| Analysis of gene-gene interactions. | Moore JH | β | 2008 | β |
| Association of IL-6 gene polymorphisms and COPD in a Spanish population. | CΓ³rdoba-LanΓΊs E et al. | β | 2008 | β |
| Bisphosphonate-related osteonecrosis of the jaws: a case-control study of risk factors in breast cancer patients. | Kyrgidis A et al. | β | 2008 | β |
| DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. | CapellΓ‘ G et al. | β | 2008 | β |
| Environment And Genetics in Lung cancer Etiology (EAGLE) study: an integrative population-based case-control study of lung cancer. | Landi MT et al. | β | 2008 | β |
| Estimating risk from copper excess in human populations. | Uauy R et al. | β | 2008 | β |
| Gene-environment interactions for complex traits: definitions, methodological requirements and challenges. | Dempfle A et al. | β | 2008 | β |
| GENetic and clinical predictors of treatment response in depression: the GenPod randomised trial protocol. | Thomas L et al. | β | 2008 | β |
| Genetic variation in CYP17 and endometrial cancer risk. | Gaudet MM et al. | β | 2008 | β |
| Human chorionic gonadotropin and alpha-fetoprotein concentrations in pregnancy and maternal risk of breast cancer: a nested case-control study. | Lukanova A et al. | β | 2008 | β |
| IL6 gene-wide haplotype is associated with susceptibility to acute lung injury. | Flores C et al. | β | 2008 | β |
| Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. | COGENT Study et al. | β | 2008 | β |
| Cohort profile: the International Childhood Cancer Cohort Consortium (I4C). | Brown RC et al. | β | 2007 | β |
| Does occupational exposure to PAHs, diesel and aromatic amines interact with smoking and metabolic genetic polymorphisms to increase the risk on bladder cancer?; The Belgian case control study on bladder cancer risk. | Kellen E et al. | β | 2007 | β |
| Gene-environment interactions in sarcoidosis: challenge and opportunity. | Culver DA et al. | β | 2007 | β |
| Polymorphisms in oxidative stress-related genes are not associated with prostate cancer risk in heavy smokers. | Choi JY et al. | β | 2007 | β |
| The association between maternal smoking in pregnancy, other early life characteristics and childhood vision: the Twins Eye Study in Tasmania. | Ponsonby AL et al. | β | 2007 | β |
| The impact of genotype misclassification errors on the power to detect a gene-environment interaction using cox proportional hazards modeling. | Tung L et al. | β | 2007 | β |
| 5' and 3' region variability in the dopamine transporter gene (SLC6A3), pesticide exposure and Parkinson's disease risk: a hypothesis-generating study. | Kelada SN et al. | β | 2006 | β |
| A CXCL2 tandem repeat promoter polymorphism is associated with susceptibility to severe sepsis in the Spanish population. | Flores C et al. | β | 2006 | β |
| Case-control genetic association studies in gastrointestinal disease: review and recommendations. | Saito YA et al. | β | 2006 | β |
| Polymorphisms in metabolic genes related to tobacco smoke and the risk of gastric cancer in the European prospective investigation into cancer and nutrition. | Agudo A et al. | β | 2006 | β |
| Evaluation of two methods for assessing gene-environment interactions using data from the Danish case-control study of facial clefts. | Etheredge AJ et al. | β | 2005 | β |
| Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population. | You WC et al. | β | 2005 | β |
| Interactions of peroxisome proliferator-activated receptor {gamma} and diet in etiology of colorectal cancer. | Murtaugh MA et al. | β | 2005 | β |
| SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. | Corella D et al. | β | 2005 | β |
| Statistical design and analysis of pharmacogenetic trials. | Kelly PJ et al. | β | 2005 | β |
| The BTNL2 gene and sarcoidosis susceptibility in African Americans and Whites. | Rybicki BA et al. | β | 2005 | β |
| The epidemiologic approach to pharmacogenomics. | Little J et al. | β | 2005 | β |
| Analysis of gene-gene interactions. | Moore JH | β | 2004 | β |
| Asbestos exposure, manganese superoxide dismutase (MnSOD) genotype, and lung cancer risk. | Wang LI et al. | β | 2004 | β |
| A survey of current software for genetic power calculations. | Knight J | β | 2004 | β |
| Bench-to-bedside review: understanding genetic predisposition to sepsis. | Villar J et al. | β | 2004 | β |
| Factorial designs: a graphical aid for choosing study designs accounting for interaction. | Byth K et al. | β | 2004 | β |
| Glutathione S-transferase M1 or T1 null genotype as a risk factor for developing multiple primary neoplasms in the upper aero-digestive tract, in Indian males using tobacco. | Jhavar S et al. | β | 2004 | β |
| No evidence of a role for PPARgamma Pro12Ala polymorphism in endometrial cancer susceptibility. | Paynter RA et al. | β | 2004 | β |
| Subgroup analyses in randomized trials: risks of subgroup-specific analyses; power and sample size for the interaction test. | Brookes ST et al. | β | 2004 | β |
| Association between self-reported environmental tobacco smoke exposure and lung cancer: modification by GSTP1 polymorphism. | Miller DP et al. | β | 2003 | β |
| Implications of genomics for public health: the role of genetic epidemiology. | Merikangas KR | β | 2003 | β |
| New developments in allotransplant immunology. | Barrett AJ et al. | β | 2003 | β |
| Occupational cancer among women: where have we been and where are we going? | Zahm SH et al. | β | 2003 | β |
| The detection of gene-environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement? | Wong MY et al. | β | 2003 | β |
| Will the genomics revolution revolutionize psychiatry? | Merikangas KR et al. | β | 2003 | β |
| Gene-environment interaction and aetiology of cancer: what does it mean and how can we measure it? | Brennan P | β | 2002 | β |
| Genetic susceptibility and gastric cancer risk. | GonzΓ‘lez CA et al. | β | 2002 | β |
| Host and viral genetics and risk of cervical cancer: a review. | Hildesheim A et al. | β | 2002 | β |
| Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk. | Benhamou S et al. | β | 2002 | β |
| Sample size requirements for matched case-control studies of gene-environment interaction. | Gauderman WJ | β | 2002 | β |
| The changing face of epidemiology in the genomics era. | Millikan R | β | 2002 | β |
| Tobacco use and cancer: an epidemiologic perspective for geneticists. | Thun MJ et al. | β | 2002 | β |
| Commentary: gene-environment interactions: fundamental yet elusive. | Burton P | β | 2001 | β |
| Sample size determination for studies of gene-environment interaction. | Luan JA et al. | β | 2001 | β |
| Sample size requirements for case-control study designs. | Edwardes MD | β | 2001 | β |
| The use of common genetic polymorphisms to enhance the epidemiologic study of environmental carcinogens. | Rothman N et al. | β | 2001 | β |
| Molecular epidemiology: on the path to prevention? | Perera FP | β | 2000 | β |
| Potential gain in efficiency and power to detect gene-environment interactions by matching in case-control studies. | StΓΌrmer T et al. | β | 2000 | β |
| Statistical designs for familial aggregation. | Liang KY et al. | β | 2000 | β |
| Case-control studies of common alleles and environmental factors. | Caporaso N et al. | β | 1999 | β |
| ras Mutations and a cup of coffee: cause, confounder, effect modifier, or what else? | Vineis P | β | 1999 | β |