A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders.
paper
Cited
Public
Unavailable
- Authors
- Leone, T C; Weinheimer, C J; Kelly, D P
- Year
- 1999
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 10377439
- DOI
- 10.1073/pnas.96.13.7473
- PMCID
- PMC22110
We hypothesized that the lipid-activated transcription factor, the peroxisome proliferator-activated receptor alpha (PPARalpha), plays a pivotal role in the cellular metabolic response to fasting. Short-term starvation caused hepatic steatosis, myocardial lipid accumulation, and hypoglycemia, with an inadequate ketogenic response in adult mice lacking PPARalpha (PPARalpha-/-), a phenotype that bears remarkable similarity to that of humans with genetic defects in mitochondrial fatty acid oxidation enzymes. In PPARalpha+/+ mice, fasting induced the hepatic and cardiac expression of PPARalpha target genes encoding key mitochondrial (medium-chain acyl-CoA dehydrogenase, carnitine palmitoyltransferase I) and extramitochondrial (acyl-CoA oxidase, cytochrome P450 4A3) enzymes. In striking contrast, the hepatic and cardiac expression of most PPARalpha target genes was not induced by fasting in PPARalpha-/- mice. These results define a critical role for PPARalpha in a transcriptional regulatory response to fasting and identify the PPARalpha-/- mouse as a potentially useful murine model of inborn and acquired abnormalities of human fatty acid utilization.
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| Annual life-stage regulation of lipid metabolism and storage and association with PPARs in a migrant species: the gray catbird (Dumetella carolinensis). | Corder KR et al. | β | 2016 | β |
| A Novel Function of Hepatic FOG2 in Insulin Sensitivity and Lipid Metabolism Through PPARΞ±. | Guo Y et al. | β | 2016 | β |
| Anti-Tumor Effects of Ketogenic Diets in Mice: A Meta-Analysis. | Klement RJ et al. | β | 2016 | β |
| Autonomic nervous system-mediated effects of galanin-like peptide on lipid metabolism in liver and adipose tissue. | Hirako S et al. | β | 2016 | β |
| Cardiac fatty acid oxidation in heart failure associated with obesity and diabetes. | Fukushima A et al. | β | 2016 | β |
| Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARΞ±. | Ratman D et al. | β | 2016 | β |
| CREB3L3 controls fatty acid oxidation and ketogenesis in synergy with PPARΞ±. | Nakagawa Y et al. | β | 2016 | β |
| Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats. | Maithilikarpagaselvi N et al. | β | 2016 | β |
| Fenofibrate Decreases Insulin Clearance and Insulin Secretion to Maintain Insulin Sensitivity. | Ramakrishnan SK et al. | β | 2016 | β |
| Fibroblast Growth Factor 21 As an Emerging Therapeutic Target for Type 2 Diabetes Mellitus. | So WY et al. | β | 2016 | β |
| Hepatic adaptations to maintain metabolic homeostasis in response to fasting and refeeding in mice. | Geisler CE et al. | β | 2016 | β |
| Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor Ξ±. | Chen X et al. | β | 2016 | β |
| Hepatic-specific PPARΞ±-FGF21 action in NAFLD. | Piccinin E et al. | β | 2016 | β |
| Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD. | Pirozzi C et al. | β | 2016 | β |
| Impact of hepatitis B virus infection on hepatic metabolic signaling pathway. | Shi YX et al. | β | 2016 | β |
| Metabolic adaptation of tissues to stress releases metabolites influencing innate immunity. | Naquet P et al. | β | 2016 | β |
| MicroRNA expression and gene regulation drive breast cancer progression and metastasis in PyMT mice. | Nogales-Cadenas R et al. | β | 2016 | β |
| MiR-122 targets the vanin 1 gene to regulate its expression in chickens. | Li Y et al. | β | 2016 | β |
| p21<sup>Cip1</sup> plays a critical role in the physiological adaptation to fasting through activation of PPARΞ±. | Lopez-Guadamillas E et al. | β | 2016 | β |
| PPAR-pan activation induces hepatic oxidative stress and lipidomic remodelling. | Ament Z et al. | β | 2016 | β |
| PPARΞ± (Peroxisome Proliferator-activated Receptor Ξ±) Activation Reduces Hepatic CEACAM1 Protein Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition. | Ramakrishnan SK et al. | β | 2016 | β |
| Regulation of Ketone Body Metabolism and the Role of PPARΞ±. | Grabacka M et al. | β | 2016 | β |
| Resveratrol enhances HBV replication through activating Sirt1-PGC-1Ξ±-PPARΞ± pathway. | Shi Y et al. | β | 2016 | β |
| Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism. | Zhang P et al. | β | 2016 | β |
| The Biochemistry and Physiology of Mitochondrial Fatty Acid Ξ²-Oxidation and Its Genetic Disorders. | Houten SM et al. | β | 2016 | β |
| Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23. | Degirolamo C et al. | β | 2016 | β |
| Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice. | Hong F et al. | β | 2015 | β |
| Adiponectin serum level in chronic hepatitis C infection and therapeutic profile. | Peta V et al. | β | 2015 | β |
| Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1Ξ±, (PGC-1Ξ±), peroxisome proliferator-activated receptor Ξ± (PPARΞ±) and estrogen related receptor Ξ± (ERRΞ±). | El Kebbaj R et al. | β | 2015 | β |
| Changes in gene expression in PBMCs profiles of PPARΞ± target genes in obese and non-obese individuals during fasting. | Felicidade I et al. | β | 2015 | β |
| Effects of PPARΞ±/PGC-1Ξ± on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro. | Yang Y et al. | β | 2015 | β |
| Fasting enriches liver triacylglycerol with n-3 polyunsaturated fatty acids: implications for understanding the adipose-liver axis in serum docosahexaenoic acid regulation. | Marks KA et al. | β | 2015 | β |
| Fish oil decreases hepatic lipogenic genes in rats fasted and refed on a high fructose diet. | de Castro GS et al. | β | 2015 | β |
| Identification of a Novel Heart-Liver Axis: Matrix Metalloproteinase-2 Negatively Regulates Cardiac Secreted Phospholipase A2 to Modulate Lipid Metabolism and Inflammation in the Liver. | Hernandez-Anzaldo S et al. | β | 2015 | β |
| Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor Ξ± (PPARΞ±) in a mouse liver gene expression compendium. | Oshida K et al. | β | 2015 | β |
| Increasing mitochondrial muscle fatty acid oxidation induces skeletal muscle remodeling toward an oxidative phenotype. | HΓ©nique C et al. | β | 2015 | β |
| Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels. | Du WW et al. | β | 2015 | β |
| Interactive effects of dietary lipid and phenotypic feed efficiency on the expression of nuclear and mitochondrial genes involved in the mitochondrial electron transport chain in rainbow trout. | Eya JC et al. | β | 2015 | β |
| Iron dextran increases hepatic oxidative stress and alters expression of genes related to lipid metabolism contributing to hyperlipidaemia in murine model. | Silva M et al. | β | 2015 | β |
| Ketone Body Therapy Protects From Lipotoxicity and Acute Liver Failure Upon PparΞ± Deficiency. | Pawlak M et al. | β | 2015 | β |
| Kinetics of lipogenic genes expression in milk purified mammary epithelial cells (MEC) across lactation and their correlation with milk and fat yield in buffalo. | Yadav P et al. | β | 2015 | β |
| Lean heart: Role of leptin in cardiac hypertrophy and metabolism. | Hall ME et al. | β | 2015 | β |
| Maintaining ancient organelles: mitochondrial biogenesis and maturation. | Vega RB et al. | β | 2015 | β |
| 'Micro-managers' of hepatic lipid metabolism and NAFLD. | Liu W et al. | β | 2015 | β |
| Mitochondrial biogenesis and dynamics in the developing and diseased heart. | Dorn GW et al. | β | 2015 | β |
| Mitochondrial sirtuins and their relationships with metabolic disease and cancer. | Kumar S et al. | β | 2015 | β |
| Myocardial metabolism in diabetic cardiomyopathy: potential therapeutic targets. | Sung MM et al. | β | 2015 | β |
| Novel genomic signals of recent selection in an Ethiopian population. | Tekola-Ayele F et al. | β | 2015 | β |
| Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future Directions. | Lee WS et al. | β | 2015 | β |
| PPARs and ERRs: molecular mediators of mitochondrial metabolism. | Fan W et al. | β | 2015 | β |
| PPARs: Protectors or Opponents of Myocardial Function? | Pol CJ et al. | β | 2015 | β |
| PPARΞ± Is Required for PPARΞ΄ Action in Regulation of Body Weight and Hepatic Steatosis in Mice. | Garbacz WG et al. | β | 2015 | β |
| Regulation and mechanism of leptin on lipid metabolism in ovarian follicle cells from yellow catfish Pelteobagrus fulvidraco. | Zhang LH et al. | β | 2015 | β |
| Renoprotective Effects of Fenofibrate via Modulation of LKB1/AMPK mRNA Expression and Endothelial Dysfunction in a Rat Model of Diabetic Nephropathy. | Al-Rasheed NM et al. | β | 2015 | β |
| The dipeptide H-Trp-Arg-OH (WR) Is a PPARΞ± agonist and reduces hepatic lipid accumulation in lipid-loaded H4IIE cells. | Jia Y et al. | β | 2015 | β |
| The impact of PPARΞ± activation on whole genome gene expression in human precision cut liver slices. | Janssen AW et al. | β | 2015 | β |
| Transcriptional regulatory circuits controlling muscle fiber type switching. | Liu J et al. | β | 2015 | β |
| Treatment with PPARΞ΄ agonist alleviates non-alcoholic fatty liver disease by modulating glucose and fatty acid metabolic enzymes in a rat model. | Li X et al. | β | 2015 | β |
| Ursolic acid improves lipid and glucose metabolism in high-fat-fed C57BL/6J mice by activating peroxisome proliferator-activated receptor alpha and hepatic autophagy. | Jia Y et al. | β | 2015 | β |
| A Moderate Zinc Deficiency Does Not Impair Gene Expression of PPARΞ±, PPARΞ³, and Mitochondrial Enoyl-CoA Delta Isomerase in the Liver of Growing Rats. | Justus J et al. | β | 2014 | β |
| Animal models of insulin resistance and heart failure. | Velez M et al. | β | 2014 | β |
| Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet. | Wang LJ et al. | β | 2014 | β |
| Bile acid-regulated peroxisome proliferator-activated receptor-Ξ± (PPARΞ±) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1. | Okamura A et al. | β | 2014 | β |
| Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1Ξ± and MED1 complex. | Tabata M et al. | β | 2014 | β |
| Cellular responses to excess fatty acids: focus on ubiquitin regulatory X domain-containing protein 8. | Kim H et al. | β | 2014 | β |
| Circadian clocks and energy metabolism. | Sancar G et al. | β | 2014 | β |
| Discovery of novel and differentially expressed microRNAs between fetal and adult backfat in cattle. | Sun J et al. | β | 2014 | β |
| Energy metabolism in the liver. | Rui L | β | 2014 | β |
| Free fatty acids and skeletal muscle insulin resistance. | Rachek LI | β | 2014 | β |
| Hepatic IRE1Ξ± regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARΞ± axis signalling. | Shao M et al. | β | 2014 | β |
| Immunologic, metabolic and genetic factors in hepatitis C virus infection. | Fierro NA et al. | β | 2014 | β |
| Impairments of hepatic gluconeogenesis and ketogenesis in PPARΞ±-deficient neonatal mice. | Cotter DG et al. | β | 2014 | β |
| Integrated physiology and systems biology of PPARΞ±. | Kersten S | β | 2014 | β |
| Lipoprotein lipase activity is required for cardiac lipid droplet production. | Trent CM et al. | β | 2014 | β |
| Liquid fructose downregulates Sirt1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells. | Rebollo A et al. | β | 2014 | β |
| Nuclear receptors and metabolism: from feast to famine. | Hong SH et al. | β | 2014 | β |
| Pharmacological doses of niacin stimulate the expression of genes involved in carnitine uptake and biosynthesis and improve the carnitine status of obese Zucker rats. | Couturier A et al. | β | 2014 | β |
| PPARA intron polymorphism associated with power performance in 30-s anaerobic Wingate Test. | Petr M et al. | β | 2014 | β |
| Regulation of energy metabolism by long-chain fatty acids. | Nakamura MT et al. | β | 2014 | β |
| Regulation of insulin on lipid metabolism in freshly isolated hepatocytes from yellow catfish (Pelteobagrus fulvidraco). | Zhuo MQ et al. | β | 2014 | β |
| Regulation of mitochondrial fatty acid Ξ²-oxidation in human: what can we learn from inborn fatty acid Ξ²-oxidation deficiencies? | Bastin J | β | 2014 | β |
| Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation. | Liu Y et al. | β | 2014 | β |
| Role of n-3 fatty acids in muscle loss and myosteatosis. | Ewaschuk JB et al. | β | 2014 | β |
| Sox17 regulates liver lipid metabolism and adaptation to fasting. | Rommelaere S et al. | β | 2014 | β |
| The effects of choline on hepatic lipid metabolism, mitochondrial function and antioxidative status in human hepatic C3A cells exposed to excessive energy substrates. | Zhu J et al. | β | 2014 | β |
| The role of albumin and PPAR-Ξ± in differentiation-dependent change of fatty acid profile during differentiation of mesenchymal stem cells to hepatocyte-like cells. | Esmaeli S et al. | β | 2014 | β |
| Tissue-specific expression of monocarboxylate transporters during fasting in mice. | Schutkowski A et al. | β | 2014 | β |
| Transcriptomic signatures of peroxisome proliferator-activated receptor Ξ± (PPARΞ±) in different mouse liver models identify novel aspects of its biology. | Szalowska E et al. | β | 2014 | β |
| Ξ²-Lapachone alleviates alcoholic fatty liver disease in rats. | Shin S et al. | β | 2014 | β |
| A critical role of fatty acid binding protein 4 and 5 (FABP4/5) in the systemic response to fasting. | Syamsunarno MR et al. | β | 2013 | β |
| Activation of PPARΞ± ameliorates hepatic insulin resistance and steatosis in high fructose-fed mice despite increased endoplasmic reticulum stress. | Chan SM et al. | β | 2013 | β |
| Activity of Bradykinin B2 Receptor Is Regulated by Long-Chain Polyunsaturated Fatty Acids. | Candelario J et al. | β | 2013 | β |
| A meta-analysis study of gene expression datasets in mouse liver under PPARΞ± knockout. | He K et al. | β | 2013 | β |
| Betaine supplement alleviates hepatic triglyceride accumulation of apolipoprotein E deficient mice via reducing methylation of peroxisomal proliferator-activated receptor alpha promoter. | Wang L et al. | β | 2013 | β |
| Cellular mechanisms regulating fuel metabolism in mammals: role of adipose tissue and lipids during prolonged food deprivation. | Viscarra JA et al. | β | 2013 | β |
| Chlorogenic acid exhibits cholesterol lowering and fatty liver attenuating properties by up-regulating the gene expression of PPAR-Ξ± in hypercholesterolemic rats induced with a high-cholesterol diet. | Wan CW et al. | β | 2013 | β |
| Differential regulation of the expressions of the PGC-1Ξ± splice variants, lipins, and PPARΞ± in heart compared to liver. | Kok BPC et al. | β | 2013 | β |
| Dynamics of PPARs, fatty acid metabolism genes and lipid classes in eggs and early larvae of a teleost. | Cunha I et al. | β | 2013 | β |
| Effects of short term fasting on the expression of genes involved in lipid metabolism in chicks. | Saneyasu T et al. | β | 2013 | β |
| Fenofibrate, a peroxisome proliferator-activated receptor Ξ± ligand, prevents abnormal liver function induced by a fasting-refeeding process. | Lee JN et al. | β | 2013 | β |
| Free radical biology for medicine: learning from nonalcoholic fatty liver disease. | Serviddio G et al. | β | 2013 | β |
| Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate. | VilΓ -Brau A et al. | β | 2013 | β |
| Individual and combined effects of Fusarium toxins on the mRNA expression of pro-inflammatory cytokines in swine jejunal epithelial cells. | Wan LY et al. | β | 2013 | β |
| In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy. | Dodd MS et al. | β | 2013 | β |
| Maternal dietary restriction alters offspring's sleep homeostasis. | Shimizu N et al. | β | 2013 | β |
| Metabolic stress in the myocardium: adaptations of gene expression. | Crawford PA et al. | β | 2013 | β |
| Mouse KLF11 regulates hepatic lipid metabolism. | Zhang H et al. | β | 2013 | β |
| Nordihydroguaiaretic acid improves metabolic dysregulation and aberrant hepatic lipid metabolism in mice by both PPARΞ±-dependent and -independent pathways. | Zhang H et al. | β | 2013 | β |
| Novel insights into ChREBP regulation and function. | Filhoulaud G et al. | β | 2013 | β |
| Nutritional lipidomics: molecular metabolism, analytics, and diagnostics. | Smilowitz JT et al. | β | 2013 | β |
| Peroxisome proliferator-activated receptor genetic polymorphisms and nonalcoholic Fatty liver disease: any role in disease susceptibility? | Dongiovanni P et al. | β | 2013 | β |
| Peroxisome proliferator-activated receptor targets for the treatment of metabolic diseases. | Monsalve FA et al. | β | 2013 | β |
| Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart. | Aubert G et al. | β | 2013 | β |
| Pex11Ξ± deficiency impairs peroxisome elongation and division and contributes to nonalcoholic fatty liver in mice. | Weng H et al. | β | 2013 | β |
| PPAR activation as a regulator of lipid metabolism, nitric oxide production and lipid peroxidation in the placenta from type 2 diabetic patients. | Capobianco E et al. | β | 2013 | β |
| PPARalpha regulates the production of serum Vanin-1 by liver. | Rommelaere S et al. | β | 2013 | β |
| RAP1: protector of telomeres, defender against obesity. | Duong MT et al. | β | 2013 | β |
| RAP1 protects from obesity through its extratelomeric role regulating gene expression. | MartΓnez P et al. | β | 2013 | β |
| Role of PPARs in inflammatory processes associated with metabolic syndrome (Review). | Fuentes E et al. | β | 2013 | β |
| Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone. | Thakran S et al. | β | 2013 | β |
| Sex-specific effects of prenatal stress on glucose homoeostasis and peripheral metabolism in rats. | Brunton PJ et al. | β | 2013 | β |
| SIRT4 represses peroxisome proliferator-activated receptor Ξ± activity to suppress hepatic fat oxidation. | Laurent G et al. | β | 2013 | β |
| The orphan nuclear receptors at their 25-year reunion. | Mullican SE et al. | β | 2013 | β |
| VASP increases hepatic fatty acid oxidation by activating AMPK in mice. | Tateya S et al. | β | 2013 | β |
| Ο-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. | O'Rourke EJ et al. | β | 2013 | β |
| Actions and interactions of AMPK with insulin, the peroxisomal-proliferator activated receptors and sirtuins. | Holness MJ et al. | β | 2012 | β |
| Applications of metabolomics for understanding the action of peroxisome proliferator-activated receptors (PPARs) in diabetes, obesity and cancer. | Ament Z et al. | β | 2012 | β |
| C/EBPΞ± promotes transcription of the porcine perilipin5 gene. | Zhou L et al. | β | 2012 | β |
| Differential effects of high-fat diet on myocardial lipid metabolism in failing and nonfailing hearts with angiotensin II-mediated cardiac remodeling in mice. | Pellieux C et al. | β | 2012 | β |
| Discovery and characterization of human exonic transcriptional regulatory elements. | Khan AH et al. | β | 2012 | β |
| Effects of L-carnitine against oxidative stress in human hepatocytes: involvement of peroxisome proliferator-activated receptor alpha. | Li JL et al. | β | 2012 | β |
| Endocrine fibroblast growth factors 15/19 and 21: from feast to famine. | Potthoff MJ et al. | β | 2012 | β |
| Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation. | Schlegel G et al. | β | 2012 | β |
| Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger? | Jensen-Urstad AP et al. | β | 2012 | β |
| FGF21 as a therapeutic reagent. | Zhao Y et al. | β | 2012 | β |
| Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor Ξ± in mouse liver reveals extensive sharing of binding sites. | Boergesen M et al. | β | 2012 | β |
| Gluconeogenesis is associated with high rates of tricarboxylic acid and pyruvate cycling in fasting northern elephant seals. | Champagne CD et al. | β | 2012 | β |
| Hepatitis C virus to hepatocellular carcinoma. | Jahan S et al. | β | 2012 | β |
| Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding. | Chambers KT et al. | β | 2012 | β |
| Liver X receptor and peroxisome proliferator-activated receptor as integrators of lipid homeostasis and immunity. | Kidani Y et al. | β | 2012 | β |
| Myocardial fatty acid metabolism and lipotoxicity in the setting of insulin resistance. | Kok BP et al. | β | 2012 | β |
| NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1Ξ² genes. | Hirotsu Y et al. | β | 2012 | β |
| Nitro-fatty acids as novel electrophilic ligands for peroxisome proliferator-activated receptors. | Ferreira AM et al. | β | 2012 | β |
| Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-chain dicarboxylic acids. | Houten SM et al. | β | 2012 | β |
| Plasma mannose-binding lectin is stimulated by PPARΞ± in humans. | Rakhshandehroo M et al. | β | 2012 | β |
| PPARs: fatty acid sensors controlling metabolism. | Poulsen Ll et al. | β | 2012 | β |
| Protection from Metabolic Dysregulation, Obesity, and Atherosclerosis by Citrus Flavonoids: Activation of Hepatic PGC1Ξ±-Mediated Fatty Acid Oxidation. | Mulvihill EE et al. | β | 2012 | β |
| PTH1 receptor is involved in mediating cellular response to long-chain polyunsaturated fatty acids. | Candelario J et al. | β | 2012 | β |
| Reduced plasma nonesterified fatty acid levels and the advent of an acute lung injury in mice after intravenous or enteral oleic acid administration. | GonΓ§alves de Albuquerque CF et al. | β | 2012 | β |
| S6 kinase 2 deficiency enhances ketone body production and increases peroxisome proliferator-activated receptor alpha activity in the liver. | Kim K et al. | β | 2012 | β |
| S-adenosylmethionine in liver health, injury, and cancer. | Lu SC et al. | β | 2012 | β |
| SRC-2 coactivator deficiency decreases functional reserve in response to pressure overload of mouse heart. | Reineke EL et al. | β | 2012 | β |
| Suppression of diet-induced hypercholesterolemia by turtle jelly, a traditional chinese functional food, in rats. | Wu JH et al. | β | 2012 | β |
| UDP-glucuronosyltransferase expression in mouse liver is increased in obesity- and fasting-induced steatosis. | Xu J et al. | β | 2012 | β |
| A Comparative Study of Mouse Hepatic and Intestinal Gene Expression Profiles under PPARΞ± Knockout by Gene Set Enrichment Analysis. | He K et al. | β | 2011 | β |
| Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes. | Goto T et al. | β | 2011 | β |
| Adaptive gene regulation of pyruvate dehydrogenase kinase isoenzyme 4 in hepatotoxic chemical-induced liver injury and its stimulatory potential for DNA repair and cell proliferation. | Dateki M et al. | β | 2011 | β |
| AMPK regulates circadian rhythms in a tissue- and isoform-specific manner. | Um JH et al. | β | 2011 | β |
| Caloric restriction in leptin deficiency does not correct myocardial steatosis: failure to normalize PPAR{alpha}/PGC1{alpha} and thermogenic glycerolipid/fatty acid cycling. | Rame JE et al. | β | 2011 | β |
| Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor Ξ³ coactivator 1Ξ±/estrogen related receptor axis. | Mitra MS et al. | β | 2011 | β |
| Cardiomyocyte-Restricted Deletion of PPARΞ²/Ξ΄ in PPARΞ±-Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of Myocardial Fatty Acid Oxidation. | Liu J et al. | β | 2011 | β |
| Changes in the 24βh Rhythmicity of Liver PPARs and Peroxisomal Markers When Feeding Is Restricted to Two Daytime Hours. | Rivera-Zavala JB et al. | β | 2011 | β |
| ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells. | Boergesen M et al. | β | 2011 | β |
| cis-9,trans-11,cis-15 and cis-9,trans-13,cis-15 CLNA mixture activates PPARΞ± in HEK293 and reduces triacylglycerols in 3T3-L1 cells. | Miranda J et al. | β | 2011 | β |
| Differential expression of metabolic genes essential for glucose and lipid metabolism in skeletal muscle from spinal cord injured subjects. | Long YC et al. | β | 2011 | β |
| Effects of the interaction of diabetes and iron supplementation on hepatic and pancreatic tissues, oxidative stress markers, and liver peroxisome proliferator-activated receptor-Ξ± expression. | Silva M et al. | β | 2011 | β |
| FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology. | Murata Y et al. | β | 2011 | β |
| Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis. | Domouzoglou EM et al. | β | 2011 | β |
| Gene expression profile change and associated physiological and pathological effects in mouse liver induced by fasting and refeeding. | Zhang F et al. | β | 2011 | β |
| Gene program-specific regulation of PGC-1{alpha} activity. | Schmidt SF et al. | β | 2011 | β |
| Heart in diabetes: not only a macrovascular disease. | Stratmann B et al. | β | 2011 | β |
| Hepatosteatosis in peroxisome deficient liver despite increased Ξ²-oxidation capacity and impaired lipogenesis. | Peeters A et al. | β | 2011 | β |
| Lipid-sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome. | Vacca M et al. | β | 2011 | β |
| Metabolic switching of human skeletal muscle cells in vitro. | Thoresen GH et al. | β | 2011 | β |
| Mitochondrial dysfunction in diabetic cardiomyopathy. | Duncan JG | β | 2011 | β |
| mRNA expression of genes involved in fatty acid utilization in skeletal muscle and white adipose tissues of sows during lactation. | Ringseis R et al. | β | 2011 | β |
| Peroxisome proliferator-activated receptor-alpha gene level differently affects lipid metabolism and inflammation in apolipoprotein E2 knock-in mice. | Lalloyer F et al. | β | 2011 | β |
| Peroxisome proliferator-activated receptor {alpha} is responsible for the up-regulation of hepatic glucose-6-phosphatase gene expression in fasting and db/db Mice. | Im SS et al. | β | 2011 | β |
| Peroxisome proliferator activated receptor-alpha (PPARΞ±) and PPAR gamma coactivator-1alpha (PGC-1Ξ±) regulation of cardiac metabolism in diabetes. | Duncan JG | β | 2011 | β |
| Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity. | Gachon F et al. | β | 2011 | β |
| Regulation of genes involved in lipid metabolism by dietary oxidized fat. | Ringseis R et al. | β | 2011 | β |
| Sex differences in nuclear receptor-regulated liver metabolic pathways. | Rando G et al. | β | 2011 | β |
| The nuclear receptor PPARΞ²/Ξ΄ programs muscle glucose metabolism in cooperation with AMPK and MEF2. | Gan Z et al. | β | 2011 | β |
| Tributyltin is a potent inhibitor of piscine peroxisome proliferator-activated receptor Ξ± and Ξ². | Colliar L et al. | β | 2011 | β |
| Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment. | Wentz AE et al. | β | 2010 | β |
| A PPARΞ± promoter variant impairs ERR-dependent transactivation and decreases mortality after acute coronary ischemia in patients with diabetes. | Cresci S et al. | β | 2010 | β |
| Conditional PPARΞ³ knockout from cardiomyocytes of adult mice impairs myocardial fatty acid utilization and cardiac function. | Luo J et al. | β | 2010 | β |
| Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice. | Elrod JW et al. | β | 2010 | β |
| Cyp4a14 overexpression induced by hyperoxia in female CBA mice as a possible contributor of increased resistance to oxidative stress. | Sobocanec S et al. | β | 2010 | β |
| Diabetic cardiomyopathy: signaling defects and therapeutic approaches. | Dobrin JS et al. | β | 2010 | β |
| Energy metabolic phenotype of the cardiomyocyte during development, differentiation, and postnatal maturation. | Lopaschuk GD et al. | β | 2010 | β |
| Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide. | Varela-Rey M et al. | β | 2010 | β |
| High density lipoprotein turnover is dependent on peroxisome proliferator-activated receptor Ξ± in mice. | Akita N et al. | β | 2010 | β |
| Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease. | Itoh N | β | 2010 | β |
| Interaction of the hepatitis C virus (HCV) core with cellular genes in the development of HCV-induced steatosis. | Khan M et al. | β | 2010 | β |
| Iron restriction improves type 2 diabetes mellitus in Otsuka Long-Evans Tokushima fatty rats. | Minamiyama Y et al. | β | 2010 | β |
| Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity. | Stienstra R et al. | β | 2010 | β |
| Liver fatty acid-binding protein and obesity. | Atshaves BP et al. | β | 2010 | β |
| MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis. | GrΓΈntved L et al. | β | 2010 | β |
| miR-519d overexpression is associated with human obesity. | Martinelli R et al. | β | 2010 | β |
| Modulation of the cardioprotective effect of ischemic preconditioning in hyperlipidaemic rat heart. | Yadav HN et al. | β | 2010 | β |
| Molecular characterization of a gilthead sea bream (Sparus aurata) muscle tissue cDNA for carnitine palmitoyltransferase 1B (CPT1B). | Boukouvala E et al. | β | 2010 | β |
| Mouse OCTN2 is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha) via a PPRE located in the first intron. | Wen G et al. | β | 2010 | β |
| Nontriglyceride hepatic lipotoxicity: the new paradigm for the pathogenesis of NASH. | Neuschwander-Tetri BA | β | 2010 | β |
| Nuclear receptors as drug targets for metabolic disease. | Schulman IG | β | 2010 | β |
| Pantothenate kinase 1 is required to support the metabolic transition from the fed to the fasted state. | Leonardi R et al. | β | 2010 | β |
| Pathogenesis of alcoholic liver disease: the role of nuclear receptors. | Gyamfi MA et al. | β | 2010 | β |
| Peroxisome proliferator activated receptor alpha (PPARalpha) and PPAR gamma coactivator (PGC-1alpha) induce carnitine palmitoyltransferase IA (CPT-1A) via independent gene elements. | Song S et al. | β | 2010 | β |
| Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism. | Frigerio F et al. | β | 2010 | β |
| Peroxisome proliferator-activated receptor alpha target genes. | Rakhshandehroo M et al. | β | 2010 | β |
| PGC-1 coactivators in cardiac development and disease. | Rowe GC et al. | β | 2010 | β |
| PPARalpha: energy combustion, hypolipidemia, inflammation and cancer. | Pyper SR et al. | β | 2010 | β |
| PPAR-beta facilitating maturation of hepatic-like tissue derived from mouse embryonic stem cells accompanied by mitochondriogenesis and membrane potential retention. | Zhu DY et al. | β | 2010 | β |
| PPARs: diverse regulators in energy metabolism and metabolic diseases. | Wang YX | β | 2010 | β |
| PPARΞ³-induced cardiolipotoxicity in mice is ameliorated by PPARΞ± deficiency despite increases in fatty acid oxidation. | Son NH et al. | β | 2010 | β |
| Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor Ξ±. | Ren H et al. | β | 2010 | β |
| Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome. | Schreurs M et al. | β | 2010 | β |
| Role of PPARΞ± in Hepatic Carbohydrate Metabolism. | Peeters A et al. | β | 2010 | β |
| The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha. | Danno H et al. | β | 2010 | β |
| The protective role of amla (Emblica officinalis Gaertn.) against fructose-induced metabolic syndrome in a rat model. | Kim HY et al. | β | 2010 | β |
| The role of peroxisome proliferator-activated receptor alpha in transcriptional regulation of novel organic cation transporters. | Eder K et al. | β | 2010 | β |
| The Role of PPARΞ± Activation in Liver and Muscle. | Burri L et al. | β | 2010 | β |
| Transcriptional profiling reveals divergent roles of PPARalpha and PPARbeta/delta in regulation of gene expression in mouse liver. | Sanderson LM et al. | β | 2010 | β |
| VLDL hydrolysis by LPL activates PPAR-alpha through generation of unbound fatty acids. | Ruby MA et al. | β | 2010 | β |
| Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice. | Wang Q et al. | β | 2009 | β |
| Adenosine signaling contributes to ethanol-induced fatty liver in mice. | Peng Z et al. | β | 2009 | β |
| Adipokines as novel modulators of lipid metabolism. | Lago F et al. | β | 2009 | β |
| A minimal model for hepatic fatty acid balance during fasting: application to PPAR alpha-deficient mice. | Blavy P et al. | β | 2009 | β |
| Apoptosis and fibrosis are early features of heart failure in an animal model of metabolic cardiomyopathy. | GΓΌrtl B et al. | β | 2009 | β |
| Cellular basis of uraemic cardiomyopathy: a role for erythropoietin? | Smith K et al. | β | 2009 | β |
| Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human. | Rakhshandehroo M et al. | β | 2009 | β |
| Dietary fat source affects metabolism of fatty acids in pigs as evaluated by altered expression of lipogenic genes in liver and adipose tissues. | Duran-MontgΓ© P et al. | β | 2009 | β |
| Differential regulation of peroxisome proliferator-activated receptor (PPAR)-alpha1 and truncated PPARalpha2 as an adaptive response to fasting in the control of hepatic peroxisomal fatty acid beta-oxidation in the hibernating mammal. | El Kebbaj Z et al. | β | 2009 | β |
| Drosophila HNF4 regulates lipid mobilization and beta-oxidation. | Palanker L et al. | β | 2009 | β |
| Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease. | Collison KS et al. | β | 2009 | β |
| Fenofibrate simultaneously induces hepatic fatty acid oxidation, synthesis, and elongation in mice. | Oosterveer MH et al. | β | 2009 | β |
| FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. | Potthoff MJ et al. | β | 2009 | β |
| Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. | Hotta Y et al. | β | 2009 | β |
| Filling gaps in PPAR-alpha signaling through comparative nutrigenomics analysis. | Cavalieri D et al. | β | 2009 | β |
| Growth hormone increases mRNA levels of PPARdelta and Foxo1 in skeletal muscle of growth hormone deficient lit/lit mice. | Kim DS et al. | β | 2009 | β |
| Hepatic triacylglycerol accumulation and insulin resistance. | Nagle CA et al. | β | 2009 | β |
| High-fat feeding in cardiomyocyte-restricted PPARdelta knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes. | Li Y et al. | β | 2009 | β |
| Hypoxia-inducible factor 2 regulates hepatic lipid metabolism. | Rankin EB et al. | β | 2009 | β |
| Liver fatty acid binding protein gene ablation enhances age-dependent weight gain in male mice. | Martin GG et al. | β | 2009 | β |
| Metabolic profiling of PPARalpha-/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation. | Makowski L et al. | β | 2009 | β |
| Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse. | Atherton HJ et al. | β | 2009 | β |
| Mouse carnitine-acylcarnitine translocase (CACT) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells. | Gutgesell A et al. | β | 2009 | β |
| Novel action of 7-O-galloyl-D-sedoheptulose isolated from Corni Fructus as a hypertriglyceridaemic agent. | Yokozawa T et al. | β | 2009 | β |
| Opposing roles of peroxisome proliferator-activated receptor alpha and growth hormone in the regulation of CYP4A11 expression in a transgenic mouse model. | Savas Γ et al. | β | 2009 | β |
| Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) but not PPARalpha serves as a plasma free fatty acid sensor in liver. | Sanderson LM et al. | β | 2009 | β |
| PPARs and the cardiovascular system. | Hamblin M et al. | β | 2009 | β |
| Proinflammatory cytokine and ligands modulate cardiac peroxisome proliferator-activated receptors. | Lee TI et al. | β | 2009 | β |
| Regulation of myocardial ketone body metabolism by the gut microbiota during nutrient deprivation. | Crawford PA et al. | β | 2009 | β |
| Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress. | Abdelmegeed MA et al. | β | 2009 | β |
| Role of PPARΞ± in the control of torpor through FGF21-NPY pathway: From circadian clock to seasonal change in mammals. | Ishida N | β | 2009 | β |
| Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity. | Chen C et al. | β | 2009 | β |
| Thioredoxin binding protein-2/thioredoxin-interacting protein is a critical regulator of insulin secretion and peroxisome proliferator-activated receptor function. | Oka S et al. | β | 2009 | β |
| Transcriptional control of the calreticulin gene in health and disease. | Qiu Y et al. | β | 2009 | β |
| Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis. | Qiu L et al. | β | 2008 | β |
| Alterations in carbohydrate metabolism and its regulation in PPARalpha null mouse hearts. | GΓ©linas R et al. | β | 2008 | β |
| Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretion. | Chen Z et al. | β | 2008 | β |
| Bioactive lipids in metabolic syndrome. | Nagao K et al. | β | 2008 | β |
| Bioinformatic profiling of the transcriptional response of adult rat cardiomyocytes to distinct fatty acids. | Lockridge JB et al. | β | 2008 | β |
| Cardiac hypertrophy is enhanced in PPAR alpha-/- mice in response to chronic pressure overload. | Smeets PJ et al. | β | 2008 | β |
| Ectopic expression of porcine peroxisome proliferator-activated receptor delta regulates adipogenesis in mouse myoblasts. | Yu YH et al. | β | 2008 | β |
| Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle. | Norris AW et al. | β | 2008 | β |
| Fenofibrate prevents orotic acid--induced hepatic steatosis in rats. | Ferreira AV et al. | β | 2008 | β |
| Hexarelin Signaling to PPARgamma in Metabolic Diseases. | Demers A et al. | β | 2008 | β |
| Integration of metabolism and inflammation by lipid-activated nuclear receptors. | Bensinger SJ et al. | β | 2008 | β |
| Interaction between PPARA genotype and beta-blocker treatment influences clinical outcomes following acute coronary syndromes. | Cresci S et al. | β | 2008 | β |
| Liver and muscle metabolic changes induced by dietary energy content and genetic selection in rainbow trout (Oncorhynchus mykiss). | Kolditz C et al. | β | 2008 | β |
| Nuclear receptors, mitochondria and lipid metabolism. | Alaynick WA | β | 2008 | β |
| Peroxisome proliferator-activated receptor alpha agonist-induced down-regulation of hepatic glucocorticoid receptor expression in SD rats. | Chen X et al. | β | 2008 | β |
| Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism. | Sharifpanah F et al. | β | 2008 | β |
| Peroxisome proliferator activated receptors and lipoprotein metabolism. | Kersten S | β | 2008 | β |
| Peroxisome proliferator-activated receptors: a therapeutic target in COPD? | Remels AH et al. | β | 2008 | β |
| PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes. | Seo YS et al. | β | 2008 | β |
| PPARalpha-mediated remodeling of repolarizing voltage-gated K+ (Kv) channels in a mouse model of metabolic cardiomyopathy. | Marionneau C et al. | β | 2008 | β |
| PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis. | Barish GD et al. | β | 2008 | β |
| PPAR Genomics and Pharmacogenomics: Implications for Cardiovascular Disease. | Cresci S | β | 2008 | β |
| PPARs and the kidney in metabolic syndrome. | Ruan X et al. | β | 2008 | β |
| Role of peroxisome proliferator-activated receptor alpha in the control of cyclooxygenase 2 and vascular endothelial growth factor: involvement in tumor growth. | Grau R et al. | β | 2008 | β |
| Role of peroxisome-proliferator-activated receptor beta/delta (PPARbeta/delta) in gastrointestinal tract function and disease. | Peters JM et al. | β | 2008 | β |
| The effect of fasting on hepatic lipid accumulation and transcriptional regulation of lipid metabolism differs between C57BL/6J and BALB/cA mice fed a high-fat diet. | Nishikawa S et al. | β | 2008 | β |
| The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis. | Reilly SJ et al. | β | 2008 | β |
| The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium. | Duncan JG et al. | β | 2008 | β |
| The PPAR trio: regulators of myocardial energy metabolism in health and disease. | Madrazo JA et al. | β | 2008 | β |
| The transcriptomic signature of fasting murine liver. | SokoloviΔ M et al. | β | 2008 | β |
| Transcriptional paradigms in mammalian mitochondrial biogenesis and function. | Scarpulla RC | β | 2008 | β |
| Transcriptional regulation of hepatic fatty acid metabolism. | Guillou H et al. | β | 2008 | β |
| Transcriptome profiling of the feeding-to-fasting transition in chicken liver. | DΓ©sert C et al. | β | 2008 | β |
| Uncoupling protein-2 modulates the lipid metabolic response to fasting in mice. | Sheets AR et al. | β | 2008 | β |
| A novel peroxisome proliferator-activated receptor responsive element-luciferase reporter mouse reveals gender specificity of peroxisome proliferator-activated receptor activity in liver. | Ciana P et al. | β | 2007 | β |
| Cardiac energy metabolism in obesity. | Lopaschuk GD et al. | β | 2007 | β |
| Comprehensive analysis of PPARalpha-dependent regulation of hepatic lipid metabolism by expression profiling. | Rakhshandehroo M et al. | β | 2007 | β |
| Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats. | Sato K et al. | β | 2007 | β |
| Effect of placental fatty acid metabolism and regulation by peroxisome proliferator activated receptor on pregnancy and fetal outcomes. | Xu Y et al. | β | 2007 | β |
| Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. | Inagaki T et al. | β | 2007 | β |
| Expression of PPARalpha modifies fatty acid effects on insulin secretion in uncoupling protein-2 knockout mice. | Fatehi-Hassanabad Z et al. | β | 2007 | β |
| FABPs as determinants of myocellular and hepatic fuel metabolism. | Binas B et al. | β | 2007 | β |
| Food entrainment of circadian gene expression altered in PPARalpha-/- brown fat and heart. | Goh BC et al. | β | 2007 | β |
| Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America. | Szczepaniak LS et al. | β | 2007 | β |
| Four weeks one-leg training and high fat diet does not alter PPARalpha protein or mRNA expression in human skeletal muscle. | Helge JW et al. | β | 2007 | β |
| Gene expression profiling in livers of mice after acute inhibition of beta-oxidation. | van der Leij FR et al. | β | 2007 | β |
| Gene expression profiling of rat liver treated with serum triglyceride-decreasing compounds. | Omura K et al. | β | 2007 | β |
| Genetic manipulations of PPARs: effects on obesity and metabolic disease. | Barak Y et al. | β | 2007 | β |
| Genome-wide analysis of PPARalpha activation in murine small intestine. | BΓΌnger M et al. | β | 2007 | β |
| Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors. | Mandard S et al. | β | 2007 | β |
| Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. | Badman MK et al. | β | 2007 | β |
| Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma. | Kim KH et al. | β | 2007 | β |
| Hormonal and nutritional regulation of muscle carnitine palmitoyltransferase I gene expression in vivo. | Liu HY et al. | β | 2007 | β |
| Hypoxia-inducible factor 1 mediates hypoxia-induced cardiomyocyte lipid accumulation by reducing the DNA binding activity of peroxisome proliferator-activated receptor alpha/retinoid X receptor. | Belanger AJ et al. | β | 2007 | β |
| In appreciation of Sir Philip Randle: the glucose-fatty acid cycle. | Sugden MC | β | 2007 | β |
| Inhibition of PPAR-alpha activity in mice with cardiac-restricted expression of tumor necrosis factor: potential role of TGF-beta/Smad3. | Sekiguchi K et al. | β | 2007 | β |
| Insulin-resistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway. | Duncan JG et al. | β | 2007 | β |
| Lipid synthesis in lactation: diet and the fatty acid switch. | Rudolph MC et al. | β | 2007 | β |
| Metabolic derangements in an adult patient with tetralogy of Fallot: possible role of chronic systemic hypoxia. | Harada E et al. | β | 2007 | β |
| n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner. | Neschen S et al. | β | 2007 | β |
| New therapeutic target for metabolic syndrome: PPARdelta. | Takahashi S et al. | β | 2007 | β |
| Nuclear receptor binding to the retinoic acid response elements of the phosphoenolpyruvate carboxykinase gene in vivo: effects of vitamin A deficiency. | Scribner KB et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptor alpha is involved in cardiomyocyte differentiation of murine embryonic stem cells in vitro. | Ding L et al. | β | 2007 | β |
| Peroxisome proliferator-activated receptor alpha polymorphisms and postprandial lipemia in healthy men. | Tanaka T et al. | β | 2007 | β |
| Pharmacogenetics of the PPAR genes and cardiovascular disease. | Cresci S | β | 2007 | β |
| PPARalpha is a key regulator of hepatic FGF21. | LundΓ₯sen T et al. | β | 2007 | β |
| PPAR delta agonists and metabolic diseases. | Kang K et al. | β | 2007 | β |
| PPARs in Calorie Restricted and Genetically Long-Lived Mice. | Masternak MM et al. | β | 2007 | β |
| Protective effect of Chinese prescription Kangen-karyu and its crude drug Tanjin against age-related lipidosis in rats. | Cho EJ et al. | β | 2007 | β |
| Roles of PPARs on regulating myocardial energy and lipid homeostasis. | Yang Q et al. | β | 2007 | β |
| RXR: from partnership to leadership in metabolic regulations. | Desvergne B | β | 2007 | β |
| Skeletal muscle adaptation to fatty acid depends on coordinated actions of the PPARs and PGC1 alpha: implications for metabolic disease. | Muoio DM et al. | β | 2007 | β |
| The GCN2 eIF2alpha kinase regulates fatty-acid homeostasis in the liver during deprivation of an essential amino acid. | Guo F et al. | β | 2007 | β |
| The protective role of Kangen-karyu against fructose-induced metabolic syndrome in a rat model. | Yokozawa T et al. | β | 2007 | β |
| Time-dependence of cardiomyocyte differentiation disturbed by peroxisome proliferator-activated receptor alpha inhibitor GW6471 in murine embryonic stem cells in vitro. | Ding L et al. | β | 2007 | β |
| Veterinary aspects and perspectives of nutrigenomics: a critical review. | Fekete SG et al. | β | 2007 | β |
| Vitamin A regulation of gene expression: molecular mechanism of a prototype gene. | McGrane MM | β | 2007 | β |
| A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome. | Atherton HJ et al. | β | 2006 | β |
| Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis. | Hruz P et al. | β | 2006 | β |
| Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. | Yoon MJ et al. | β | 2006 | β |
| Caloric restriction and intermittent fasting: two potential diets for successful brain aging. | Martin B et al. | β | 2006 | β |
| Chronic activation of PPARalpha is detrimental to cardiac recovery after ischemia. | Sambandam N et al. | β | 2006 | β |
| Deranged energy substrate metabolism in the failing heart. | Tian Q et al. | β | 2006 | β |
| Developmental and tissue-specific involvement of peroxisome proliferator-activated receptor-alpha in the control of mouse uncoupling protein-3 gene expression. | Pedraza N et al. | β | 2006 | β |
| Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice. | Burgess SC et al. | β | 2006 | β |
| Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism. | Matsumoto M et al. | β | 2006 | β |
| Effects of PPARalpha on cardiac glucose metabolism: a transcriptional equivalent of the glucose-fatty acid cycle? | Finck BN | β | 2006 | β |
| From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. | Feige JN et al. | β | 2006 | β |
| Identification of longevity-associated genes in long-lived Snell and Ames dwarf mice. | Boylston WH et al. | β | 2006 | β |
| Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome. | Oka S et al. | β | 2006 | β |
| Induction of intestinal peptide transporter 1 expression during fasting is mediated via peroxisome proliferator-activated receptor alpha. | Shimakura J et al. | β | 2006 | β |
| Investigational PPAR-gamma agonists for the treatment of Type 2 diabetes. | Savkur RS et al. | β | 2006 | β |
| Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway. | Finck BN et al. | β | 2006 | β |
| MLDP, a novel PAT family protein localized to lipid droplets and enriched in the heart, is regulated by peroxisome proliferator-activated receptor alpha. | Yamaguchi T et al. | β | 2006 | β |
| Modulation of hepatic inflammatory risk markers of cardiovascular diseases by PPAR-alpha activators: clinical and experimental evidence. | Zambon A et al. | β | 2006 | β |
| Nuclear receptor expression links the circadian clock to metabolism. | Yang X et al. | β | 2006 | β |
| Obesity, peroxisome proliferator-activated receptor, and atherosclerosis in type 2 diabetes. | Blaschke F et al. | β | 2006 | β |
| Obesity-related derangements in metabolic regulation. | Muoio DM et al. | β | 2006 | β |
| Orphan nuclear receptors: therapeutic opportunities in skeletal muscle. | Smith AG et al. | β | 2006 | β |
| OXPAT/PAT-1 is a PPAR-induced lipid droplet protein that promotes fatty acid utilization. | Wolins NE et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor alpha agonist, clofibrate, has profound influence on myocardial fatty acid composition. | Tian Q et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets. | Lalloyer F et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression. | Patsouris D et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor delta (PPARdelta), a novel target site for drug discovery in metabolic syndrome. | Takahashi S et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor delta promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage. | Lee CH et al. | β | 2006 | β |
| Peroxisome proliferator-activated receptor-gamma: novel therapeutic target linking adiposity, insulin resistance, and atherosclerosis. | Kepez A et al. | β | 2006 | β |
| PPARdelta regulates glucose metabolism and insulin sensitivity. | Lee CH et al. | β | 2006 | β |
| Prevention of adipose tissue depletion during food deprivation in angiotensin type 2 receptor-deficient mice. | Yvan-Charvet L et al. | β | 2006 | β |
| Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. | Newberry EP et al. | β | 2006 | β |
| Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis. | Shibata N et al. | β | 2006 | β |
| Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. | An D et al. | β | 2006 | β |
| Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. | Lefebvre P et al. | β | 2006 | β |
| Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice. | De Souza AT et al. | β | 2006 | β |
| Transcriptional regulation of metabolism. | Desvergne B et al. | β | 2006 | β |
| A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. | Van Gilst MR et al. | β | 2005 | β |
| AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. | Assifi MM et al. | β | 2005 | β |
| A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetes. | Finck BN et al. | β | 2005 | β |
| Deficiency of PPARalpha disturbs the response of lipogenic flux and of lipogenic and cholesterogenic gene expression to dietary cholesterol in mouse white adipose tissue. | Islam KK et al. | β | 2005 | β |
| Deletion of the angiotensin type 2 receptor (AT2R) reduces adipose cell size and protects from diet-induced obesity and insulin resistance. | Yvan-Charvet L et al. | β | 2005 | β |
| Evaluation of the carcinogenic potential of clofibrate in the neonatal mouse. | Nesfield SR et al. | β | 2005 | β |
| Fatty acid metabolism is enhanced in type 2 diabetic hearts. | Carley AN et al. | β | 2005 | β |
| Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms. | Tachibana K et al. | β | 2005 | β |
| Induction of overlapping genes by fasting and a peroxisome proliferator in pigs: evidence of functional PPARalpha in nonproliferating species. | Cheon Y et al. | β | 2005 | β |
| Mitochondrial energy metabolism in heart failure: a question of balance. | Huss JM et al. | β | 2005 | β |
| Moderate caloric restriction, but not physiological hyperleptinemia per se, enhances mitochondrial oxidative capacity in rat liver and skeletal muscle--tissue-specific impact on tissue triglyceride content and AKT activation. | Barazzoni R et al. | β | 2005 | β |
| Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes. | Tan NS et al. | β | 2005 | β |
| Nutrigenomics: the impact of biomics technology on nutrition research. | CorthΓ©sy-Theulaz I et al. | β | 2005 | β |
| Peroxisome proliferator-activated receptor alpha is required for feedback regulation of highly unsaturated fatty acid synthesis. | Li Y et al. | β | 2005 | β |
| Peroxisome proliferator-activated receptor gamma coactivator 1 in caloric restriction and other models of longevity. | Corton JC et al. | β | 2005 | β |
| PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia. | Panagia M et al. | β | 2005 | β |
| Retinoid x receptor heterodimers in the metabolic syndrome. | Shulman AI et al. | β | 2005 | β |
| Role of AMP-activated protein kinase in the coordinated expression of genes controlling glucose and lipid metabolism in mouse white skeletal muscle. | Long YC et al. | β | 2005 | β |
| Skeletal muscle and nuclear hormone receptors: implications for cardiovascular and metabolic disease. | Smith AG et al. | β | 2005 | β |
| The gene encoding acyl-CoA-binding protein is subject to metabolic regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes. | Sandberg MB et al. | β | 2005 | β |
| The PPAR genes, cardiovascular disease and the emergence of PPAR pharmacogenetics. | Cresci S | β | 2005 | β |
| Three peroxisome proliferator-activated receptor isotypes from each of two species of marine fish. | Leaver MJ et al. | β | 2005 | β |
| Transcriptional regulation of lipid metabolism by fatty acids: a key determinant of pancreatic beta-cell function. | Fatehi-Hassanabad Z et al. | β | 2005 | β |
| Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response. | Feingold K et al. | β | 2004 | β |
| Animal models of nonalcoholic fatty liver disease and steatohepatitis. | Nanji AA | β | 2004 | β |
| Bile acid signaling to the nucleus: finding new connections in the transcriptional regulation of metabolic pathways. | De Fabiani E et al. | β | 2004 | β |
| Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization. | Zhu M et al. | β | 2004 | β |
| Diurnal variations in the responsiveness of cardiac and skeletal muscle to fatty acids. | Stavinoha MA et al. | β | 2004 | β |
| "Energenetics" of heart failure. | van Bilsen M | β | 2004 | β |
| Evidence for mitochondrial thioesterase 1 as a peroxisome proliferator-activated receptor-alpha-regulated gene in cardiac and skeletal muscle. | Stavinoha MA et al. | β | 2004 | β |
| Fatty liver in familial hypobetalipoproteinemia: roles of the APOB defects, intra-abdominal adipose tissue, and insulin sensitivity. | Tanoli T et al. | β | 2004 | β |
| Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. | An J et al. | β | 2004 | β |
| Leptin and the control of respiratory gene expression in muscle. | McClelland GB et al. | β | 2004 | β |
| Lipolytic PPAR activation: new insights into the intersection of triglycerides and inflammation? | Ziouzenkova O et al. | β | 2004 | β |
| Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice. | Erol E et al. | β | 2004 | β |
| Liver-X-receptor-mediated increase in ATP-binding cassette transporter A1 expression is attenuated by fatty acids in CaCo-2 cells: effect on cholesterol efflux to high-density lipoprotein. | Murthy S et al. | β | 2004 | β |
| Mechanisms of regulation of gene expression by fatty acids. | Nakamura MT et al. | β | 2004 | β |
| Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice. | Paterson JM et al. | β | 2004 | β |
| Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. | Corton JC et al. | β | 2004 | β |
| Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases. | Westin MA et al. | β | 2004 | β |
| Molecular mechanisms of alcoholic fatty liver: role of peroxisome proliferator-activated receptor alpha. | Crabb DW et al. | β | 2004 | β |
| Non-alcoholic fatty liver and insulin resistance: a cause-effect relationship? | Bugianesi E et al. | β | 2004 | β |
| Nuclear receptor signaling and cardiac energetics. | Huss JM et al. | β | 2004 | β |
| Nuclear receptors in macrophage biology: at the crossroads of lipid metabolism and inflammation. | Castrillo A et al. | β | 2004 | β |
| Peroxisome proliferator-activated receptor-beta as a target for wound healing drugs. | Tan NS et al. | β | 2004 | β |
| PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. | Koo SH et al. | β | 2004 | β |
| Potential role of peroxisome proliferator-activated receptor-alpha in the modulation of glucose-stimulated insulin secretion. | Sugden MC et al. | β | 2004 | β |
| PPARalpha governs glycerol metabolism. | Patsouris D et al. | β | 2004 | β |
| Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting. | Spriet LL et al. | β | 2004 | β |
| Reduced expression of peroxisome proliferator-activated receptor-alpha may have an important role in the development of non-alcoholic fatty liver disease. | Yeon JE et al. | β | 2004 | β |
| Requirement of PPARalpha in maintaining phospholipid and triacylglycerol homeostasis during energy deprivation. | Lee SS et al. | β | 2004 | β |
| Sexual dimorphism in lipid metabolic phenotype associated with old age in Sprague-Dawley rats. | Sanguino E et al. | β | 2004 | β |
| Structure, function, and dietary regulation of delta6, delta5, and delta9 desaturases. | Nakamura MT et al. | β | 2004 | β |
| The biology of peroxisome proliferator-activated receptors: relationship with lipid metabolism and insulin sensitivity. | FerrΓ© P | β | 2004 | β |
| The ketogenic diet; fatty acids, fatty acid-activated receptors and neurological disorders. | Cullingford TE | β | 2004 | β |
| The role of the peroxisome proliferator-activated receptor alpha pathway in pathological remodeling of the diabetic heart. | Finck BN | β | 2004 | β |
| Bezafibrate is a dual ligand for PPARalpha and PPARbeta: studies using null mice. | Peters JM et al. | β | 2003 | β |
| Biliary lipid secretion, membrane pumps, and the metabolic response to fasting: distinct PPAR-ts of a common regulatory pathway. | Newberry EP et al. | β | 2003 | β |
| Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice. | Ip E et al. | β | 2003 | β |
| Combined effects of PPARgamma2 P12A and PPARalpha L162V polymorphisms on glucose and insulin homeostasis: the QuΓ©bec Family Study. | BossΓ© Y et al. | β | 2003 | β |
| Controlling muscle mitochondrial content. | Moyes CD | β | 2003 | β |
| Control of human carnitine palmitoyltransferase II gene transcription by peroxisome proliferator-activated receptor through a partially conserved peroxisome proliferator-responsive element. | Barrero MJ et al. | β | 2003 | β |
| Decreased hepatic triglyceride accumulation and altered fatty acid uptake in mice with deletion of the liver fatty acid-binding protein gene. | Newberry EP et al. | β | 2003 | β |
| Dietary effect of different high-fat diet on rat liver stereology. | Aguila MB et al. | β | 2003 | β |
| Energy balance: a new role for PPARalpha. | Rosen ED | β | 2003 | β |
| Essential fatty acid synthesis and its regulation in mammals. | Nakamura MT et al. | β | 2003 | β |
| HIV protease inhibitor ritonavir induces lipoatrophy in male mice. | Goetzman ES et al. | β | 2003 | β |
| Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse. | Kok T et al. | β | 2003 | β |
| Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice. | Knight BL et al. | β | 2003 | β |
| Inhibition of peroxisome proliferator-activated receptor alpha signaling by vitamin D receptor. | Sakuma T et al. | β | 2003 | β |
| Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone. | Holness MJ et al. | β | 2003 | β |
| Liver gene expression in rats in response to the peroxisome proliferator-activated receptor-alpha agonist ciprofibrate. | Yadetie F et al. | β | 2003 | β |
| Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance. | Conarello SL et al. | β | 2003 | β |
| Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. | Norris AW et al. | β | 2003 | β |
| Myocardial dysfunction and male mortality in peroxisome proliferator-activated receptor alpha knockout mice overexpressing lipoprotein lipase in muscle. | NΓΆhammer C et al. | β | 2003 | β |
| Myocardial metabolic regulation through peroxisome proliferator-activated receptor alpha after myocardial infarction. | Masamura K et al. | β | 2003 | β |
| Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. | Fischer M et al. | β | 2003 | β |
| Peroxisome proliferator-activated receptor (PPAR) alpha and PPARbeta/delta, but not PPARgamma, modulate the expression of genes involved in cardiac lipid metabolism. | Gilde AJ et al. | β | 2003 | β |
| Peroxisome proliferator-activated receptors (PPARS): regulators of gene expression in heart and skeletal muscle. | Gilde AJ et al. | β | 2003 | β |
| PPARalpha agonist-induced rodent tumors: modes of action and human relevance. | Klaunig JE et al. | β | 2003 | β |
| Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs. | Sugden MC et al. | β | 2003 | β |
| Regulation of fatty acid and cholesterol synthesis: co-operation or competition? | Gibbons GF | β | 2003 | β |
| Regulation of myocardial triacylglycerol synthesis and metabolism. | Lewin TM et al. | β | 2003 | β |
| Regulation of triacylglycerol hydrolase expression by dietary fatty acids and peroxisomal proliferator-activated receptors. | Dolinsky VW et al. | β | 2003 | β |
| Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormones. | Jalouli M et al. | β | 2003 | β |
| Skeletal muscle metabolism in physiology and in cancer disease. | Giordano A et al. | β | 2003 | β |
| 85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells. | Han C et al. | β | 2002 | β |
| Acyl-coenzyme A dehydrogenases are localized on GLUT4-containing vesicles via association with insulin-regulated aminopeptidase in a manner dependent on its dileucine motif. | Katagiri H et al. | β | 2002 | β |
| Adaptation and maladaptation of the heart in diabetes: Part II: potential mechanisms. | Young ME et al. | β | 2002 | β |
| Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha. | Nagai Y et al. | β | 2002 | β |
| A role for peroxisome proliferator-activated receptor alpha (PPARalpha ) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase. | Campbell FM et al. | β | 2002 | β |
| Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism. | Hunt MC et al. | β | 2002 | β |
| Comparative effect of fenofibrate on hepatic desaturases in wild-type and peroxisome proliferator-activated receptor alpha-deficient mice. | Guillou H et al. | β | 2002 | β |
| Delayed induction of delta-6 and delta-5 desaturases by a peroxisome proliferator. | Song He W et al. | β | 2002 | β |
| Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice. | Gregoire FM et al. | β | 2002 | β |
| Effects of fatty acids on gene expression: role of peroxisome proliferator-activated receptor alpha, liver X receptor alpha and sterol regulatory element-binding protein-1c. | Kersten S | β | 2002 | β |
| Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism. | Holness MJ et al. | β | 2002 | β |
| Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. | Muoio DM et al. | β | 2002 | β |
| Gene regulatory mechanisms governing energy metabolism during cardiac hypertrophic growth. | Lehman JJ et al. | β | 2002 | β |
| Has angiogenesis been invited to the PPARty? | Barger PM | β | 2002 | β |
| Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese Zucker rat heart. | Young ME et al. | β | 2002 | β |
| New insights into long-chain fatty acid uptake by heart muscle: a crucial role for fatty acid translocase/CD36. | Brinkmann JF et al. | β | 2002 | β |
| Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin. | Sugden MC et al. | β | 2002 | β |
| Peroxisome proliferator-activated receptor alpha (PPARalpha) influences substrate utilization for hepatic glucose production. | Xu J et al. | β | 2002 | β |
| Peroxisome proliferator-activated receptor alpha (PPARalpha) signaling in the gene regulatory control of energy metabolism in the normal and diseased heart. | Finck BN et al. | β | 2002 | β |
| Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. | Muoio DM et al. | β | 2002 | β |
| Peroxisome proliferator activated receptors and obesity. | Kersten S | β | 2002 | β |
| Peroxisome proliferator-activated receptors: lipid binding proteins controling gene expression. | van Bilsen M et al. | β | 2002 | β |
| Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis. | Barbier O et al. | β | 2002 | β |
| Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements. | Yoshikawa T et al. | β | 2002 | β |
| Regulation of P450 4A expression by peroxisome proliferator activated receptors. | Johnson EF et al. | β | 2002 | β |
| Regulatory networks controlling mitochondrial energy production in the developing, hypertrophied, and diabetic heart. | Finck BN et al. | β | 2002 | β |
| The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus. | Finck BN et al. | β | 2002 | β |
| The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents. | Helledie T et al. | β | 2002 | β |
| The ketogenic diet upregulates expression of the gene encoding the key ketogenic enzyme mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in rat brain. | Cullingford TE et al. | β | 2002 | β |
| The peroxisome proliferator-activated receptor alpha-selective activator ciprofibrate upregulates expression of genes encoding fatty acid oxidation and ketogenesis enzymes in rat brain. | Cullingford TE et al. | β | 2002 | β |
| Transcriptional activation of energy metabolic switches in the developing and hypertrophied heart. | Lehman JJ et al. | β | 2002 | β |
| Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha. | Wu P et al. | β | 2001 | β |
| Characterization of the rodent genes for arylacetamide deacetylase, a putative microsomal lipase, and evidence for transcriptional regulation. | Trickett JI et al. | β | 2001 | β |
| GATA-4 and serum response factor regulate transcription of the muscle-specific carnitine palmitoyltransferase I beta in rat heart. | Moore ML et al. | β | 2001 | β |
| Hypoxia inhibits the peroxisome proliferator-activated receptor alpha/retinoid X receptor gene regulatory pathway in cardiac myocytes: a mechanism for O2-dependent modulation of mitochondrial fatty acid oxidation. | Huss JM et al. | β | 2001 | β |
| Identification of peroxisome proliferator-responsive human genes by elevated expression of the peroxisome proliferator-activated receptor alpha in HepG2 cells. | Hsu MH et al. | β | 2001 | β |
| Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice. | Morton NM et al. | β | 2001 | β |
| Influence of conjugated linoleic acid on body composition and target gene expression in peroxisome proliferator-activated receptor alpha-null mice. | Peters JM et al. | β | 2001 | β |
| Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. | Louet JF et al. | β | 2001 | β |
| Mice expressing only the mutant APOE3Leiden gene show impaired VLDL secretion. | Mensenkamp AR et al. | β | 2001 | β |
| Molecular enzymology of carnitine transfer and transport. | Ramsay RR et al. | β | 2001 | β |
| Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal beta-oxidation, PPAR alpha, and steatohepatitis. | Reddy JK | β | 2001 | β |
| p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response. | Barger PM et al. | β | 2001 | β |
| Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic system. | Reddy JK et al. | β | 2001 | β |
| Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines. | Akiyama TE et al. | β | 2001 | β |
| Peroxisome proliferator-activated receptor (PPAR) modulators: diabetes and beyond. | Jones AB | β | 2001 | β |
| Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice. | Torra IP et al. | β | 2001 | β |
| PGC-1, a versatile coactivator. | Knutti D et al. | β | 2001 | β |
| PPAR-alpha-null mice are protected from high-fat diet-induced insulin resistance. | Guerre-Millo M et al. | β | 2001 | β |
| Recent advances in P450 research. | Raucy JL et al. | β | 2001 | β |
| Regulation of cardiac and skeletal muscle malonyl-CoA decarboxylase by fatty acids. | Young ME et al. | β | 2001 | β |
| Responses of insulin-like growth factor (IGF)-I and IGF-binding proteins to nutritional status in peroxisome proliferator-activated receptor-alpha knockout mice. | Lewitt MS et al. | β | 2001 | β |
| The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism. | Kersten S et al. | β | 2001 | β |
| Uncoupling protein 3 transcription is regulated by peroxisome proliferator-activated receptor (alpha) in the adult rodent heart. | Young ME et al. | β | 2001 | β |
| Variation at position 162 of peroxisome proliferator-activated receptor alpha does not influence the effect of fibrates on cholesterol or triacylglycerol concentrations in hyperlipidaemic subjects. | Puckey LH et al. | β | 2001 | β |
| Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators. | Lazennec G et al. | β | 2000 | β |
| Analysis of the expression of murine glutaryl-CoA dehydrogenase: in vitro and in vivo studies. | Woontner M et al. | β | 2000 | β |
| Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. | Kersten S et al. | β | 2000 | β |
| Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity. | Watanabe K et al. | β | 2000 | β |
| Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha. | Tobin KA et al. | β | 2000 | β |
| CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis. | Leclercq IA et al. | β | 2000 | β |
| Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth. | Barger PM et al. | β | 2000 | β |
| Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. | Hashimoto T et al. | β | 2000 | β |
| Disorders of fatty acid transport and mitochondrial oxidation: challenges and dilemmas of metabolic evaluation. | Rinaldo P et al. | β | 2000 | β |
| Effect of endurance training on lipid metabolism in women: a potential role for PPARalpha in the metabolic response to training. | Horowitz JF et al. | β | 2000 | β |
| Genomics of the human carnitine acyltransferase genes. | van der Leij FR et al. | β | 2000 | β |
| Leptin: an essential regulator of lipid metabolism. | Reidy SP et al. | β | 2000 | β |
| Less extrahepatic induction of fatty acid beta-oxidation enzymes by PPAR alpha. | Cook WS et al. | β | 2000 | β |
| Omega-3 polyunsaturated fatty acid regulation of gene expression. | Price PT et al. | β | 2000 | β |
| Peroxisome proliferator-activated receptor alpha-mediated pathways are altered in hepatocyte-specific retinoid X receptor alpha-deficient mice. | Wan YJ et al. | β | 2000 | β |
| Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. | Lehman JJ et al. | β | 2000 | β |
| PPARalpha agonists reduce 11beta-hydroxysteroid dehydrogenase type 1 in the liver. | Hermanowski-Vosatka A et al. | β | 2000 | β |
| PPAR signaling in the control of cardiac energy metabolism. | Barger PM et al. | β | 2000 | β |
| Reduced hepatic fatty acid oxidation in fasting PPARalpha null mice is due to impaired mitochondrial hydroxymethylglutaryl-CoA synthase gene expression. | Le May C et al. | β | 2000 | β |
| Regulation of lipid and lipoprotein metabolism by PPAR activators. | Gervois P et al. | β | 2000 | β |
| Roles of PPARs in health and disease. | Kersten S et al. | β | 2000 | β |
| The acute phase response is associated with retinoid X receptor repression in rodent liver. | Beigneux AP et al. | β | 2000 | β |
| The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. | Vega RB et al. | β | 2000 | β |
| The peroxisome proliferator-activated receptor alpha (PPARalpha) regulates bile acid biosynthesis. | Hunt MC et al. | β | 2000 | β |
| Peroxisome proliferator-activated receptors: nuclear control of metabolism. | Desvergne B et al. | β | 1999 | β |
| Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions. | Michalik L et al. | β | 1999 | β |