The effects of opioid peptides on dopamine release in the nucleus accumbens: an in vivo microdialysis study.
paper
Cited
Public
Unavailable
- Authors
- Spanagel, R; Herz, A; Shippenberg, T S
- Year
- 1990
- Journal
- Journal of neurochemistry
- PMID
- 1976759
- DOI
- 10.1111/j.1471-4159.1990.tb04963.x
An involvement of the mesolimbic dopamine (DA) system in mediating the motivational effects of opioids has been suggested. Accordingly, the present study employed the technique of in vivo microdialysis to examine the effects of selective mu-, delta-, and kappa- opioids on DA release in the nucleus accumbens (NAC) of anesthetized rats. Microdialysis probes were inserted into the NAC and perfusates were analyzed for DA and its metabolites, dihydroxyphenylacetic acid (DO-PAC) and homovanillic acid (HVA), using a reverse-phase HPLC system with electrochemical detection for separation and quantification. Intracerebroventricular (i.c.v.) administration of selective mu-opioid [D-Ala2, N-methyl-Phe4, Gly5-ol]-enkephalin (DAMGO) or delta-opioid [D-Pen2, D-Pen5]-enkephalin (DPDPE) agonists, at doses that function as positive reinforcers in rats, resulted in an immediate and significant increase in extracellular DA. DOPAC and HVA levels were also significantly increased. The effects of DAMGO were blocked by the selective mu-antagonist D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) whereas those of DPDPE were blocked by the delta-antagonist allyl2-Tyr-Aib-Aib-Phe-Leu-OH (ICI 174,864). In contrast to mu- and delta-agonists, the kappa-agonist N-CH3-Tyr-Gly-Gly-Phe-Leu-Arg-N-CH3-Arg-D-Leu-NHC2H5 (E-2078), a dynorphin analog that produces aversive states, decreased DA release in a biphasic manner. Norbinaltorphimine, a selective kappa-antagonist, could block this effect. These results demonstrate that mu-, delta-, and kappa-opioid agonists differentially affect DA release in the NAC and this action is centrally mediated.
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| Paradoxical effects of prodynorphin gene deletion on basal and cocaine-evoked dopaminergic neurotransmission in the nucleus accumbens. | Chefer VI et al. | β | 2006 | β |
| Repeated administration of the selective kappa-opioid receptor agonist U-69593 increases stimulated dopamine extracellular levels in the rat nucleus accumbens. | Fuentealba JA et al. | β | 2006 | β |
| Cocaine and heroin ('speedball') self-administration: the involvement of nucleus accumbens dopamine and mu-opiate, but not delta-opiate receptors. | Cornish JL et al. | β | 2005 | β |
| Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats. | Beardsley PM et al. | β | 2005 | β |
| Glycyl-glutamine in nucleus accumbens reduces ethanol intake in alcohol preferring (P) rats. | Resch GE et al. | β | 2005 | β |
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| Interactions among mu- and delta-opioid receptors, especially putative delta1- and delta2-opioid receptors, promote dopamine release in the nucleus accumbens. | Hirose N et al. | β | 2005 | β |
| Intracerebroventricular D-Pen2, D-Pen5-enkephalin administration soon after stressor imposition influences behavioral responsivity to a subsequent stressor encounter in CD-1 mice. | Hebb AL et al. | β | 2005 | β |
| Kappa opioids as potential treatments for stimulant dependence. | Prisinzano TE et al. | β | 2005 | β |
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| mu-Opioids disinhibit and kappa-opioids inhibit serotonin efflux in the dorsal raphe nucleus. | Tao R et al. | β | 2005 | β |
| Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity? | Bart G et al. | β | 2005 | β |
| Pathobiology of dynorphins in trauma and disease. | Hauser KF et al. | β | 2005 | β |
| Systemic and intra-accumbens microinjections of naltrexone interfere with tolerance to ethanol in rats. | Varaschin RK et al. | β | 2005 | β |
| The contribution of genetics to addiction therapy approaches. | Edenberg HJ et al. | β | 2005 | β |
| The opioidergic-alcohol link : implications for treatment. | Modesto-Lowe V et al. | β | 2005 | β |
| Cocaine seeking over extended withdrawal periods in rats: time dependent increases of responding induced by heroin priming over the first 3 months. | Lu L et al. | β | 2004 | β |
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| Deltorphin II enhances extracellular levels of dopamine in the nucleus accumbens via opioid receptor-independent mechanisms. | Murakawa K et al. | β | 2004 | β |
| Effect of the kappa opioid agonist R-84760 on cocaine-induced increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. | Zhang Y et al. | β | 2004 | β |
| Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys. | Negus SS | β | 2004 | β |
| Endogenous opioids and feeding behavior: a 30-year historical perspective. | Bodnar RJ | β | 2004 | β |
| Evolving perspectives on neurobiological research on the addictions: celebration of the 30th anniversary of NIDA. | Kreek MJ et al. | β | 2004 | β |
| Genetic and pharmacological manipulation of mu opioid receptors in mice reveals a differential effect on behavioral sensitization to cocaine. | Hummel M et al. | β | 2004 | β |
| Involvement of corticostriatal glutamatergic terminals in striatal dopamine release elicited by stimulation of delta-opioid receptors. | Billet F et al. | β | 2004 | β |
| Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. | Yuferov V et al. | β | 2004 | β |
| Role of mu- and delta-opioid receptors in the nucleus accumbens in turning behaviour of rats. | Matsuzaki S et al. | β | 2004 | β |
| Basal and morphine-evoked dopaminergic neurotransmission in the nucleus accumbens of MOR- and DOR-knockout mice. | Chefer VI et al. | β | 2003 | β |
| Beta-funaltrexamine affects cocaine self-administration in rats responding on a progressive ratio schedule of reinforcement. | Ward SJ et al. | β | 2003 | β |
| DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity. | Gengo PJ et al. | β | 2003 | β |
| Increased dopamine D2 receptor binding and enhanced apomorphine-induced locomotor activity in mu-opioid receptor knockout mice. | Tien LT et al. | β | 2003 | β |
| Interactions between opioids and cocaine on locomotor activity in rats: influence of an opioid's relative efficacy at the mu receptor. | Smith MA et al. | β | 2003 | β |
| Lack of effect of kappa-opioid receptor agonism on long-term methamphetamine-induced neurotoxicity in rats. | Johnson-Davis KL et al. | β | 2003 | β |
| Nonspecific effects of the selective kappa-opioid receptor agonist U-50,488H on dopamine uptake and release in PC12 cells. | Chudapongse N et al. | β | 2003 | β |
| Nucleus accumbens opioid, GABaergic, and dopaminergic modulation of palatable food motivation: contrasting effects revealed by a progressive ratio study in the rat. | Zhang M et al. | β | 2003 | β |
| Suppressed prolactin response to dynorphin A1-13 in methadone-maintained versus control subjects. | Bart G et al. | β | 2003 | β |
| Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects. | Li T et al. | β | 2002 | β |
| Catecholamines and methods for their identification and quantitation in biological tissues and fluids. | Bergquist J et al. | β | 2002 | β |
| Chronic morphine treatment modulates the extracellular levels of endogenous enkephalins in rat brain structures involved in opiate dependence: a microdialysis study. | Nieto MM et al. | β | 2002 | β |
| Effects of cocaine on c-fos and preprodynorphin mRNA levels in intact and ovariectomized Fischer rats. | Jenab S et al. | β | 2002 | β |
| Endogenous opioids in dopaminergic cell body regions modulate amphetamine-induced increases in extracellular dopamine levels in the terminal regions. | Schad CA et al. | β | 2002 | β |
| Estrogen and opioids interact to modulate the locomotor response to cocaine in the female rat. | Febo M et al. | β | 2002 | β |
| Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect. | Newton SS et al. | β | 2002 | β |
| Inhibition of THIP on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity. | Yoon IS et al. | β | 2002 | β |
| Motivational effects mu- and kappa-opioid agonists following acute and chronic restraint stress: involvement of dopamine D(1) and D(2) receptors. | del Rosario Capriles N et al. | β | 2002 | β |
| Mu-receptor agonism with alfentanil increases striatal dopamine D2 receptor binding in man. | Hagelberg N et al. | β | 2002 | β |
| Neurobiology of relapse to heroin and cocaine seeking: a review. | Shalev U et al. | β | 2002 | β |
| Opioid receptor subtypes differentially modulate serotonin efflux in the rat central nervous system. | Tao R et al. | β | 2002 | β |
| Orphanin FQ/nociceptin but not Ro 65-6570 inhibits the expression of cocaine-induced conditioned place preference. | KotliΕska J et al. | β | 2002 | β |
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| Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system. | Keck ME et al. | β | 2002 | β |
| The biochemical bases for reward. Implications for the placebo effect. | De La Fuente-FernΓ‘ndez R et al. | β | 2002 | β |
| Ultrastructural localization of enkephalin and mu-opioid receptors in the rat ventral tegmental area. | GarzΓ³n M et al. | β | 2002 | β |
| A concept of welfare based on reward evaluating mechanisms in the brain: anticipatory behaviour as an indicator for the state of reward systems. | Spruijt BM et al. | β | 2001 | β |
| Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens. | Pliakas AM et al. | β | 2001 | β |
| Antiparkinsonian action of a delta opioid agonist in rodent and primate models of Parkinson's disease. | Hille CJ et al. | β | 2001 | β |
| Different motivational effects induced by the endogenous mu-opioid receptor ligands endomorphin-1 and -2 in the mouse. | Narita M et al. | β | 2001 | β |
| Effects of kappa-opioid receptor agonists on long-term cocaine use and dopamine neurotransmission. | Collins SL et al. | β | 2001 | β |
| Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism. | Gianoulakis C | β | 2001 | β |
| Inhibition of baclofen on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity. | Woo SH et al. | β | 2001 | β |
| Inhibition of diazepam on morphine-induced hyperactivity, reverse tolerance and postsynaptic dopamine receptor supersensitivity. | Woo SH et al. | β | 2001 | β |
| Intravenous self-administration of heroin/cocaine combinations (speedball) using nose-poke or lever-press operant responding in mice. | David V et al. | β | 2001 | β |
| Kappa opioid agonists alter dopamine markers and cocaine-stimulated locomotor activity. | Collins SL et al. | β | 2001 | β |
| kappa-Opioid receptor agonist-induced prolactin release in primates is blocked by dopamine D(2)-like receptor agonists. | Butelman ER et al. | β | 2001 | β |
| Lack of dependence and rewarding effects of deltorphin II in mu-opioid receptor-deficient mice. | Hutcheson DM et al. | β | 2001 | β |
| Major coexpression of kappa-opioid receptors and the dopamine transporter in nucleus accumbens axonal profiles. | Svingos AL et al. | β | 2001 | β |
| Modulation of the behavioral and neurochemical effects of psychostimulants by kappa-opioid receptor systems. | Shippenberg TS et al. | β | 2001 | β |
| Overview of microdialysis. | Shippenberg TS et al. | β | 2001 | β |
| Prodynorphin and kappa opioid receptor mRNA expression in the cingulate and prefrontal cortices of subjects diagnosed with schizophrenia or affective disorders. | Peckys D et al. | β | 2001 | β |
| Regulation of opioid receptors by cocaine. | Unterwald EM | β | 2001 | β |
| Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain. | Keck ME et al. | β | 2000 | β |
| Analysis of dopamine receptor antagonism upon feeding elicited by mu and delta opioid agonists in the shell region of the nucleus accumbens. | Ragnauth A et al. | β | 2000 | β |
| Cocaine and methamphetamine differentially affect opioid peptide mRNA expression in the striatum. | Adams DH et al. | β | 2000 | β |
| Effect of nociceptin/orphanin FQ on the rewarding properties of morphine. | Ciccocioppo R et al. | β | 2000 | β |
| Effects of neuroactive substances on the morphine-induced respiratory depression; an in vitro study. | Takita K et al. | β | 2000 | β |
| Effects of rolipram, a selective inhibitor of phosphodiesterase 4, on hyperlocomotion induced by several abused drugs in mice. | Mori T et al. | β | 2000 | β |
| Kappa-opioid receptor modulation of nicotine-induced behaviour. | Hahn B et al. | β | 2000 | β |
| kappa-Opioid receptors in the substantia nigra pars reticulata mediate the U-50,488-induced locomotor activity of preweanling rats. | Collins RL et al. | β | 2000 | β |
| Mapping of c-fos gene expression in the brain during morphine dependence and precipitated withdrawal, and phenotypic identification of the striatal neurons involved. | Georges F et al. | β | 2000 | β |
| Modulation of the discriminative stimulus effects of d-amphetamine by mu and kappa opioids in squirrel monkeys. | Powell KR et al. | β | 2000 | β |
| Modulation of the neurotoxic effects of methamphetamine by the selective kappa-opioid receptor agonist U69593. | El Daly E et al. | β | 2000 | β |
| Nociceptin differentially affects morphine-induced dopamine release from the nucleus accumbens and nucleus caudate in rats. | Di Giannuario A et al. | β | 2000 | β |
| Opioid propeptide mRNA content and receptor density in the brains of AA and ANA rats. | Marinelli PW et al. | β | 2000 | β |
| Repeated ethanol administration induces short- and long-term changes in enkephalin and dynorphin tissue concentrations in rat brain. | Lindholm S et al. | β | 2000 | β |
| Acute intermittent morphine increases preprodynorphin and kappa opioid receptor mRNA levels in the rat brain. | Wang XM et al. | β | 1999 | β |
| Cellular responses of nucleus accumbens neurons to opiate-seeking behavior: I. Sustained responding during heroin self-administration. | Lee RS et al. | β | 1999 | β |
| Cellular sites for dynorphin activation of kappa-opioid receptors in the rat nucleus accumbens shell. | Svingos AL et al. | β | 1999 | β |
| Comparison of the proopiomelanocortin and proenkephalin opioid peptide systems in brain regions of the alcohol-preferring C57BL/6 and alcohol-avoiding DBA/2 mice. | Jamensky NT et al. | β | 1999 | β |
| D3 dopamine and kappa opioid receptor alterations in human brain of cocaine-overdose victims. | Mash DC et al. | β | 1999 | β |
| Involvement of dopamine D(1) and D(2) receptors in the ethanol-associated place preference in rats exposed to conditioned fear stress. | Matsuzawa S et al. | β | 1999 | β |
| kappa-Opioid tolerance and dependence in cultures of dopaminergic midbrain neurons. | Dalman FC et al. | β | 1999 | β |
| Localization of the delta-opioid receptor and dopamine transporter in the nucleus accumbens shell: implications for opiate and psychostimulant cross-sensitization. | Svingos AL et al. | β | 1999 | β |
| Locomotor-activity-induced changes in striatal levels of preprotachykinin and preproenkephalin mRNA. Regulation by the dopaminergic and glutamatergic systems. | Liste I et al. | β | 1999 | β |
| Modification of naloxone-induced withdrawal signs by dextromethorphan in morphine-dependent mice. | Farzin D | β | 1999 | β |
| Opioid modulation of ventral pallidal inputs. | Napier TC et al. | β | 1999 | β |
| Orphanin FQ/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis. | Murphy NP et al. | β | 1999 | β |
| Sensitization to daily morphine injections in rats with unilateral lesions of the substantia nigra. | Volpicelli LA et al. | β | 1999 | β |
| The adrenergic receptor agonist, clonidine, potentiates the anti-parkinsonian action of the selective kappa-opioid receptor agonist, enadoline, in the monoamine-depleted rat. | Hill MP et al. | β | 1999 | β |
| The dopamine hypothesis of reward: past and current status. | Spanagel R et al. | β | 1999 | β |
| The role of dopamine in the nucleus accumbens in analgesia. | Altier N et al. | β | 1999 | β |
| Cellular sites for activation of delta-opioid receptors in the rat nucleus accumbens shell: relationship with Met5-enkephalin. | Svingos AL et al. | β | 1998 | β |
| Comparison of mesocorticolimbic neuronal responses during cocaine and heroin self-administration in freely moving rats. | Chang JY et al. | β | 1998 | β |
| Different effects of opiate withdrawal on dopamine turnover, uptake, and release in the striatum and nucleus accumbens. | Ghosh S et al. | β | 1998 | β |
| Drug dependence: stress and dysregulation of brain reward pathways. | Kreek MJ et al. | β | 1998 | β |
| Effects of clozapine on the delta- and kappa-opioid receptors and the G-protein-activated K+ (GIRK) channel expressed in Xenopus oocytes. | Kobayashi T et al. | β | 1998 | β |
| Effects of repeated psychostimulant administration on the prodynorphin system activity and kappa opioid receptor density in the rat brain. | Turchan J et al. | β | 1998 | β |
| Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide. | Sillaber I et al. | β | 1998 | β |
| Increased responsiveness of mesolimbic and mesostriatal dopamine neurons to cocaine following repeated administration of a selective kappa-opioid receptor agonist. | Heidbreder CA et al. | β | 1998 | β |
| Opioid receptor gene expression in the rat brain during ontogeny, with special reference to the mesostriatal system: an in situ hybridization study. | Georges F et al. | β | 1998 | β |
| Opioid receptor modulation of feeding-evoked dopamine release in the rat nucleus accumbens. | Taber MT et al. | β | 1998 | β |
| Opioid reward mechanisms: a key role in drug abuse? | Herz A | β | 1998 | β |
| Pharmacological stimuli decreasing nucleus accumbens dopamine can act as positive reinforcers but have a low addictive potential. | Marinelli M et al. | β | 1998 | β |
| Regulation of cocaine reward by CREB. | Carlezon WA et al. | β | 1998 | β |
| Repeated treatment with the selective kappa opioid agonist U-69593 produces a marked depletion of dopamine D2 receptors. | Izenwasser S et al. | β | 1998 | β |
| Role of central opioid receptor subtypes in morphine-induced alterations in peripheral lymphocyte activity. | Mellon RD et al. | β | 1998 | β |
| Antisense oligodeoxynucleotide to delta opioid receptors blocks cocaine-induced place preference in mice. | Suzuki T et al. | β | 1997 | β |
| Blockade by naloxone of cocaine-induced hyperactivity, reverse tolerance and conditioned place preference in mice. | Kim HS et al. | β | 1997 | β |
| Characterization of the mu and delta opioid receptors in the brain of the C57BL/6 and DBA/2 mice, selected for their differences in voluntary ethanol consumption. | de Waele JP et al. | β | 1997 | β |
| Content of dynorphins and kappa-opioid receptors in distinct brain regions of C57BL/6 and DBA/2 mice. | Jamensky NT et al. | β | 1997 | β |
| DAMGO and DPDPE facilitation of brain stimulation reward thresholds is blocked by the dopamine antagonist cis-flupenthixol. | Duvauchelle CL et al. | β | 1997 | β |
| Delayed occurrence of enhanced striatal preprodynorphin gene expression in behaviorally sensitized rats: differential long-term effects of intermittent and chronic morphine administration. | Tjon GH et al. | β | 1997 | β |
| Differential effects of mu-, delta- and kappa-opioid receptor agonists on the discriminative stimulus properties of cocaine in rats. | Suzuki T et al. | β | 1997 | β |
| Effects of opioids on the absorption of alcohol. | Linseman MA et al. | β | 1997 | β |
| Effects of single and repeated morphine administration on the prodynorphin, proenkephalin and dopamine D2 receptor gene expression in the mouse brain. | Turchan J et al. | β | 1997 | β |
| Evaluation of opioid receptor subtype antagonist effects in the ventral tegmental area upon food intake under deprivation, glucoprivic and palatable conditions. | Ragnauth A et al. | β | 1997 | β |
| Infusions of tyrosine hydroxylase antisense oligodeoxynucleotide into substantia nigra of the rat: effects on tyrosine hydroxylase mRNA and protein content, striatal dopamine release and behaviour. | Skutella T et al. | β | 1997 | β |
| Involvement of cholinergic neurons in the release of dopamine elicited by stimulation of mu-opioid receptors in striatum. | Dourmap N et al. | β | 1997 | β |
| Involvement of dopamine-dependent and -independent mechanisms in the rewarding effects mediated by delta opioid receptor subtypes in mice. | Suzuki T et al. | β | 1997 | β |
| Kappa2 opioid receptors in limbic areas of the human brain are upregulated by cocaine in fatal overdose victims. | Staley JK et al. | β | 1997 | β |
| Kappa-opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug-naive rats and mice. | Kuzmin AV et al. | β | 1997 | β |
| Morphine enhances selection of both sucrose and ethanol in a two-bottle test. | Stromberg MF et al. | β | 1997 | β |
| mu-, delta- and kappa-opioid receptor agonists do not alter the discriminative stimulus effects of cocaine or d-amphetamine in rats. | Woolfolk DR et al. | β | 1997 | β |
| Naltrexone effects on ethanol drinking acquisition and on established ethanol consumption in C57BL/6J mice. | Phillips TJ et al. | β | 1997 | β |
| Neuronal responses in prefrontal cortex and nucleus accumbens during heroin self-administration in freely moving rats. | Chang JY et al. | β | 1997 | β |
| Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands. | Calderon SN et al. | β | 1997 | β |
| Systemic morphine-induced Fos protein in the rat striatum and nucleus accumbens is regulated by mu opioid receptors in the substantia nigra and ventral tegmental area. | Bontempi B et al. | β | 1997 | β |
| The role of delta-opioid receptors in the discriminative stimulus properties of a low dose of methamphetamine. | Suzuki T et al. | β | 1997 | β |
| Up-regulation of dopamine D1-receptors in the brain of 28-day-old rats exposed to the delta (delta) opioid agonist SNC80 during the preweaning period. | Shieh GJ et al. | β | 1997 | β |
| Acute and repeated activation of male sexual behavior by tail pinch: opioid and dopaminergic mechanisms. | Leyton M et al. | β | 1996 | β |
| Addiction: brain mechanisms and their treatment implications. | Nutt DJ | β | 1996 | β |
| Alcohol addiction (alcoholism) and the opioid system. | Terenius L | β | 1996 | β |
| D1 and D2 receptor regulation of preproenkephalin and preprodynorphin mRNA in rat striatum following acute injection of amphetamine or methamphetamine. | Wang JQ et al. | β | 1996 | β |
| Effects of sigma ligands on the cloned mu-, delta- and kappa-opioid receptors co-expressed with G-protein-activated K+ (GIRK) channel in Xenopus oocytes. | Kobayashi T et al. | β | 1996 | β |
| Effects of the kappa-opioid receptor agonist U-50,488 on morphine-induced place preference conditioning in the developing rat. | Bolanos CA et al. | β | 1996 | β |
| Immunohistochemical localization of the cloned kappa 1 receptor in the rat CNS and pituitary. | Mansour A et al. | β | 1996 | β |
| Individual and combined effects of ethanol and cocaine on intracellular signals and gene expression. | Torres G et al. | β | 1996 | β |
| Morphine-induced increase in D-1 receptor regulated signal transduction in rat striatal neurons and its facilitation by glucocorticoid receptor activation: possible role in behavioral sensitization. | Schoffelmeer AN et al. | β | 1996 | β |
| Morphine-induced locomotor and neurochemical stimulation is enhanced in transgenic mice with impaired glucocorticoid receptor function. | Spanagel B et al. | β | 1996 | β |
| Naloxone-precipitated changes in biogenic amines and their metabolites in various brain regions of butorphanol-dependent rats. | Tokuyama S et al. | β | 1996 | β |
| Neuropharmacological characterization of local ibogaine effects on dopamine release. | Reid MS et al. | β | 1996 | β |
| The effect of single and repeated morphine administration on the prodynorphin system activity in the nucleus accumbens and striatum of the rat. | PrzewΕocka B et al. | β | 1996 | β |
| The effects of dopamine D1 and D2 receptor antagonists on the rewarding effects of delta 1 and delta 2 opioid receptor agonists in mice. | Suzuki T et al. | β | 1996 | β |
| Assessment of the discriminative stimulus effects of cocaine in the rat: lack of interaction with opioids. | Broadbent J et al. | β | 1995 | β |
| Brain dynorphin and enkephalin systems in Fischer and Lewis rats: effects of morphine tolerance and withdrawal. | Nylander I et al. | β | 1995 | β |
| Curve-shift analysis of self-stimulation in food-restricted rats: relationship between daily meal, plasma corticosterone and reward sensitization. | Abrahamsen GC et al. | β | 1995 | β |
| Dynorphin-immunoreactive neurons in the rat nucleus accumbens: ultrastructure and synaptic input from terminals containing substance P and/or dynorphin. | Van Bockstaele EJ et al. | β | 1995 | β |
| Effects of acute and chronic morphine on rotational behavior in nigral-lesioned rats. | Kimmel HL et al. | β | 1995 | β |
| Effects of selective opioid receptor antagonists on morphine-induced changes in striatal and limbic dopamine metabolism. | Piepponen TP et al. | β | 1995 | β |
| Electrochemical evidence of increased dopamine transmission in prefrontal cortex and nucleus accumbens elicited by ventral tegmental mu-opioid receptor activation in freely behaving rats. | Noel MB et al. | β | 1995 | β |
| Intrastriatal injection of opioid receptor agonists inhibits apomorphine-induced behavior in 6-hydroxydopamine-treated mice. | Toyoshi T et al. | β | 1995 | β |
| Modulation of drug-induced sensitization processes by endogenous opioid systems. | Spanagel R | β | 1995 | β |
| Neuronal adaptation to amphetamine and dopamine: molecular mechanisms of prodynorphin gene regulation in rat striatum. | Cole RL et al. | β | 1995 | β |
| Opioid effects on spinal [3H]5-hydroxytryptamine release are not related to their antinociceptive action. | Monroe PJ et al. | β | 1995 | β |
| Prior morphine exposure enhances ibogaine antagonism of morphine-induced locomotor stimulation. | Pearl SM et al. | β | 1995 | β |
| The delta-opioid receptor antagonist naltrindole prevents sensitization to the conditioned rewarding effects of cocaine. | Shippenberg TS et al. | β | 1995 | β |
| The effects of morphine treatment and morphine withdrawal on the dynorphin and enkephalin systems in Sprague-Dawley rats. | Nylander I et al. | β | 1995 | β |
| The effects of repeated amphetamine administration on the thyrotropin-releasing hormone level. Its release and receptors in the rat brain. | Jaworska-Feil L et al. | β | 1995 | β |
| The effects of the kappa agonist U-50,488 on cocaine-induced conditioned and unconditioned behaviors and Fos immunoreactivity. | Crawford CA et al. | β | 1995 | β |
| Transgenic superoxide dismutase mice differ in opioid-induced analgesia. | Elmer GI et al. | β | 1995 | β |
| Ventral tegmental injections of a selective mu or delta opioid enhance feeding in food-deprived rats. | Noel MB et al. | β | 1995 | β |
| A pharmacological profile of the novel, peripherally-selective kappa-opioid receptor agonist, EMD 61753. | Barber A et al. | β | 1994 | β |
| Attenuation of the discriminative stimulus properties of cocaine by delta-opioid receptor antagonists. | Suzuki T et al. | β | 1994 | β |
| Autoradiographic distribution of mu opioid receptors in the brains of Cu/Zn-superoxide dismutase mice. | Kujirai K et al. | β | 1994 | β |
| Brain sites involved in delta-opioid receptor-mediated actions. | Ableitner A | β | 1994 | β |
| Central and peripheral actions of the novel kappa-opioid receptor agonist, EMD 60400. | Barber A et al. | β | 1994 | β |
| Comparative effects of selective kappa-opioid receptor agonists on dopamine levels in the dorsal caudate of freely moving rats. | Zaratin P et al. | β | 1994 | β |
| Dynorphin-immunoreactive terminals in the rat nucleus accumbens: cellular sites for modulation of target neurons and interactions with catecholamine afferents. | Van Bockstaele EJ et al. | β | 1994 | β |
| Effects of diabetes on spontaneous locomotor activity in mice. | Kamei J et al. | β | 1994 | β |
| Endogenous kappa-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release. | Spanagel R et al. | β | 1994 | β |
| Enhanced activity of the brain beta-endorphin system by free-choice ethanol drinking in C57BL/6 but not DBA/2 mice. | De Waele JP et al. | β | 1994 | β |
| Influence of naloxone upon motor activity induced by psychomotor stimulant drugs. | Jones DN et al. | β | 1994 | β |
| In vivo treatment with mu and delta, but not kappa-selective opioid agonists reduces [3H]spiperone binding to the guinea-pig striatum: autoradiographic evidence. | Brent PJ et al. | β | 1994 | β |
| Involvement of kappa-opioid receptors in opioid dependence/withdrawal: studies using butorphanol. | Jaw SP et al. | β | 1994 | β |
| Involvement of mesolimbic kappa-opioid systems in the discriminative stimulus effects of morphine. | Spanagel R et al. | β | 1994 | β |
| Modulation by catecholamine of hypothalamus-pituitary-adrenocortical (HPA) axis activity in morphine-tolerance and withdrawal. | Martinez-PiΓ±ero MG et al. | β | 1994 | β |
| Monoamine systems in the discriminative effects of spiradoline, a kappa-opioid agonist. | Holtzman SG et al. | β | 1994 | β |
| Morphine induces c-fos and junB in striatum and nucleus accumbens via D1 and N-methyl-D-aspartate receptors. | Liu J et al. | β | 1994 | β |
| Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: an in situ hybridization study. | Mansour A et al. | β | 1994 | β |
| -mu opiate receptor. Charged transmembrane domain amino acids are critical for agonist recognition and intrinsic activity. | Surratt CK et al. | β | 1994 | β |
| Neurobiological mechanisms controlling aggression: preclinical developments for pharmacotherapeutic interventions. | Miczek KA et al. | β | 1994 | β |
| NMDA receptors mediate amphetamine-induced upregulation of zif/268 and preprodynorphin mRNA expression in rat striatum. | Wang JQ et al. | β | 1994 | β |
| Role of kainate/AMPA receptors in induction of striatal zif/268 and preprodynorphin mRNA by a single injection of amphetamine. | Wang JQ et al. | β | 1994 | β |
| U50,488, a kappa opioid receptor agonist, attenuates cocaine-induced increases in extracellular dopamine in the nucleus accumbens of rats. | Maisonneuve IM et al. | β | 1994 | β |
| Buprenorphine-cocaine interactions in mice: effect on locomotor activity and hole-dipping behaviour. | Jackson HC et al. | β | 1993 | β |
| Centrally administered mu- and delta-opioid agonists increase operant responding for saccharin. | Gosnell BA et al. | β | 1993 | β |
| Cocaine-like discriminative stimulus properties of the delta-selective opioid receptor agonist, [D-Pen2,L-Pen5]enkephalin, in the rat. | Ukai M et al. | β | 1993 | β |
| DAMGO ([D-Ala2,NMePhe4,Gly-ol]enkephalin), but not DPLPE ([D-Pen2,L- Pen5]enkephalin), specifically inhibits methamphetamine-induced behavioral responses in the mouse. | Ukai M et al. | β | 1993 | β |
| Delta-opioid receptor antagonists attenuate motor activity induced by amphetamine but not cocaine. | Jones DN et al. | β | 1993 | β |
| delta-Opioid receptor-mediated regulation of central dopaminergic neurons in the rat. | Manzanares J et al. | β | 1993 | β |
| Dynorphin A-(1-13) markedly improves scopolamine-induced impairment of spontaneous alternation performance in mice. | Itoh J et al. | β | 1993 | β |
| Inhibition of cocaine-induced sensitization by the delta-opioid receptor antagonist naltrindole. | Heidbreder C et al. | β | 1993 | β |
| Interacting presynaptic kappa-opioid and GABAA receptors modulate dopamine release from rat striatal synaptosomes. | Ronken E et al. | β | 1993 | β |
| Naltrexone reverses ethanol-induced dopamine release in the nucleus accumbens in awake, freely moving rats. | Benjamin D et al. | β | 1993 | β |
| Opioid receptor-mediated inhibition of evoked catecholamine release from cultured neurons of rat ventral mesencephalon and locus coeruleus. | Ronken E et al. | β | 1993 | β |
| Peripherally administered substance P affects extracellular dopamine concentrations in the neostriatum but not in the nucleus accumbens under anesthesia. | Boix F et al. | β | 1993 | β |
| Receptor-selective opioid peptides fail to affect behavioral responses induced by a low dose of apomorphine in the mouse. | Ukai M et al. | β | 1993 | β |
| The kappa-opioid receptor agonist U-69593 attenuates cocaine-induced behavioral sensitization in the rat. | Heidbreder CA et al. | β | 1993 | β |
| Ventral tegmental injections of morphine but not U-50,488H enhance feeding in food-deprived rats. | Noel MB et al. | β | 1993 | β |
| Attenuation of the inhibitory effect of dynorphin on dopamine release in the rat nucleus accumbens by repeated treatment with methamphetamine. | Yokoo H et al. | β | 1992 | β |
| Cocaine place preference is blocked by the delta-opioid receptor antagonist, naltrindole. | Menkens K et al. | β | 1992 | β |
| Conditioning of opioid reinforcement: neuroanatomical and neurochemical substrates. | Shippenberg TS et al. | β | 1992 | β |
| Differential effect of intrastriatal kainic acid on the modulation of dopamine release by mu- and delta-opioid peptides: a microdialysis study. | Dourmap N et al. | β | 1992 | β |
| Dopamine depletion produces augmented behavioral responses to a mu-, but not a delta-opioid receptor agonist in the nucleus accumbens: lack of a role for receptor upregulation. | Churchill L et al. | β | 1992 | β |
| Effect of the 5-HT3 receptor antagonists, MDL72222 and ondansetron on morphine place conditioning. | Higgins GA et al. | β | 1992 | β |
| Ethanol-induced increase in endogenous dopamine release may involve endogenous opiates. | Widdowson PS et al. | β | 1992 | β |
| Infusions of 6-hydroxydopamine into the nucleus accumbens abolish the analgesic effect of amphetamine but not of morphine in the formalin test. | Clarke PB et al. | β | 1992 | β |
| Morphine, D-Pen2, D-Pen5 enkephalin and U50,488H differentially affect the locomotor activity and behaviours induced by quinpirole in guinea-pigs. | Brent PJ et al. | β | 1992 | β |
| Morphine withdrawal aggression: modification with D1 and D2 receptor agonists. | Tidey JW et al. | β | 1992 | β |
| Multidimensional behavioral analyses show dynorphin A-(1-13) modulation of methamphetamine-induced behaviors in mice. | Ukai M et al. | β | 1992 | β |
| Naloxone reduces amphetamine-induced stimulation of locomotor activity and in vivo dopamine release in the striatum and nucleus accumbens. | Hooks MS et al. | β | 1992 | β |
| Opioidergic modulation of cocaine conditioned place preferences. | Bilsky EJ et al. | β | 1992 | β |
| Opioid receptors and inhibition of dopamine-sensitive adenylate cyclase in slices of rat brain regions receiving a dense dopaminergic input. | Heijna MH et al. | β | 1992 | β |
| Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. | Spanagel R et al. | β | 1992 | β |
| Precipitation of morphine withdrawal syndrome in rats by administration of mu-, delta- and kappa-selective opioid antagonists. | Maldonado R et al. | β | 1992 | β |
| Striatal extracellular dopamine in conscious vs. anesthetized rats: effects of chloral hydrate anesthetic on responses to drugs of different classes. | Hamilton ME et al. | β | 1992 | β |
| The stimulation of central kappa opioid receptors decreases male sexual behavior and locomotor activity. | Leyton M et al. | β | 1992 | β |
| Beta-endorphin-induced locomotor stimulation and reinforcement are associated with an increase in dopamine release in the nucleus accumbens. | Spanagel R et al. | β | 1991 | β |
| Heroin addiction: neurobiology, pharmacology, and policy. | Goldstein A | β | 1991 | β |
| Modulation of the mesolimbic dopaminergic system by beta-endorphin-(1-27) as assessed by microdialysis. | Spanagel R et al. | β | 1991 | β |