A global overview of pleiotropy and genetic architecture in complex traits.
paper
Cited
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- Authors
- Watanabe, Kyoko; Stringer, Sven; Frei, Oleksandr; UmiΔeviΔ Mirkov, MaΕ‘a; de Leeuw, Christiaan; Polderman, Tinca J C; van der Sluis, Sophie; Andreassen, Ole A; Neale, Benjamin M; Posthuma, Danielle
- Year
- 2019
- Journal
- Nature genetics
- PMID
- 31427789
- DOI
- 10.1038/s41588-019-0481-0
After a decade of genome-wide association studies (GWASs), fundamental questions in human genetics, such as the extent of pleiotropy across the genome and variation in genetic architecture across traits, are still unanswered. The current availability of hundreds of GWASs provides a unique opportunity to address these questions. We systematically analyzed 4,155 publicly available GWASs. For a subset of well-powered GWASs on 558 traits, we provide an extensive overview of pleiotropy and genetic architecture. We show that trait-associated loci cover more than half of the genome, and 90% of these overlap with loci from multiple traits. We find that potential causal variants are enriched in coding and flanking regions, as well as in regulatory elements, and show variation in polygenicity and discoverability of traits. Our results provide insights into how genetic variation contributes to trait variation. All GWAS results can be queried and visualized at the GWAS ATLAS resource ( https://atlas.ctglab.nl ).
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| Conserved NT5C2 links context-specific behaviors with psychiatric and metabolic risk. | Moulin TC et al. | β | 2026 | β |
| Cross-ancestry information transfer framework improves protein abundance prediction and protein-trait association identification. | Zhai W et al. | β | 2026 | β |
| Detection of pleiotropic genetic factors and critical brain cell types linking insomnia with psychiatric disorders. | Xue B et al. | β | 2026 | β |
| DisCP-Atlas: a comprehensive resource mapping cellular processes to complex diseases. | Wang FQ et al. | β | 2026 | β |
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| Genome-wide association study of neuropathic pain. | Spildrejorde M et al. | β | 2026 | β |
| Genome-wide meta-analyses of cross substance use disorders in diverse populations. | Lai D et al. | β | 2026 | β |
| Genomic Structural Equation Modeling Reveals Cardiovascular-Kidney-Metabolic Syndrome Genetic Architecture. | Lu C et al. | β | 2026 | β |
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| Impacts of host genetics on gut microbiome composition in Alzheimer's disease. | Liu J et al. | β | 2026 | β |
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| Large-scale blood pressure GWAS accounting for gene-depression interactions in 564,680 individuals from diverse populations. | Lee S et al. | β | 2026 | β |
| Mapping the genetic landscape across 14 psychiatric disorders. | Grotzinger AD et al. | β | 2026 | β |
| Methylome-Wide Association Study of Obsessive-Compulsive Disorder. | HΓΆffler KD et al. | β | 2026 | β |
| Mitigating Sex-Related Biases to Elucidate the Autism Phenotype. | Burrows CA et al. | β | 2026 | β |
| Molecular polymorphisms that underlie trait variation in crops: Lessons learned from soybean. | Espina MJC et al. | β | 2026 | β |
| Molecular systems, human noncoding sequence variants, and blood pressure. | Qiu Q et al. | β | 2026 | β |
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| OmiGA for ultra-efficient molecular quantitative trait loci mapping. | Teng J et al. | β | 2026 | β |
| Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity. | Pascat V et al. | β | 2026 | β |
| Phantom epistasis through the lens of genealogies. | Ignatieva A et al. | β | 2026 | β |
| Predictive prioritization of enhancers associated with pancreatic disease risk. | Wang L et al. | β | 2026 | β |
| scVMAP: a comprehensive platform for integrating single-cell chromatin accessibility regions with causal variants. | Yu ZM et al. | β | 2026 | β |
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| Short-term and persistent changes to the muscle transcriptome of Lake sturgeon (Acipenser fulvescens) following early-life exposures to elevated temperatures. | Bugg WS et al. | β | 2026 | β |
| Specificity, length and luck drive gene rankings in association studies. | Spence JP et al. | β | 2026 | β |
| The causal effects of dementia on systemic sclerosis: a two-sample bidirectional Mendelian randomization study. | Xiao J et al. | β | 2026 | β |
| The ChickenGTEx portal: a pan-tissue catalogue of regulatory variants shaping transcriptomic and phenotypic diversity. | Hou Y et al. | β | 2026 | β |
| Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries. | Khan Y et al. | β | 2026 | β |
| Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors. | Holt DJ et al. | β | 2026 | β |
| Unveiling the hidden genetic conundrum linking pulmonary diseases and neuropsychiatric disorders: Novel insights from advanced omics-based analyses of the lung-brain axis. | Ding S et al. | β | 2026 | β |
| A cis-regulatory element controls expression of histone deacetylase 9 to fine-tune inflammasome-dependent chronic inflammation in atherosclerosis. | Asare Y et al. | β | 2025 | β |
| Admixture's impact on Brazilian population evolution and health. | Nunes K et al. | β | 2025 | β |
| A genetic exploration of the relationship between posttraumatic stress disorder and cardiovascular diseases. | Lukas E et al. | β | 2025 | β |
| A genetic map of human metabolism across the allele frequency spectrum. | Zoodsma M et al. | β | 2025 | β |
| A genome-wide analysis of the shared genetic risk architecture of complex neurological and psychiatric disorders. | Smeland OB et al. | β | 2025 | β |
| A genome-wide association study identifies genetic variants associated with hip pain in the UK Biobank cohort (Nβ=β221,127). | Pan Q et al. | β | 2025 | β |
| A genome-wide pleiotropy study between atopic dermatitis and neuropsychiatric disorders. | Antonatos C et al. | β | 2025 | β |
| A multi-level exploration of the genetic basis between lung cancer and schizophrenia. | Wu L et al. | β | 2025 | β |
| A one-shot, lossless algorithm for cross-cohort learning in mixed-outcomes analysis. | Li R et al. | β | 2025 | β |
| A path integral approach for allele frequency dynamics under polygenic selection. | Anderson NW et al. | β | 2025 | β |
| A pilot multi-omics study reveals genetic mechanisms regulating milk component traits in dairy cattle. | Zheng W et al. | β | 2025 | β |
| Association between antidiabetic drug targets and psychiatric disorders. | Yuan R et al. | β | 2025 | β |
| A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies. | Li X et al. | β | 2025 | β |
| Atad1 Is a Potential Candidate Gene for Prepulse Inhibition. | Bajpai AK et al. | β | 2025 | β |
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| Biomarker identification for Alzheimer's disease through integration of comprehensive Mendelian randomization and proteomics data. | Zhan H et al. | β | 2025 | β |
| Bone mineral density and cardiovascular diseases: a two-sample Mendelian randomization study. | Salih AM et al. | β | 2025 | β |
| Brain functional connectivity correlates of autism diagnosis and familial liability in 24-month-olds. | Pruett JR et al. | β | 2025 | β |
| Brain-heart-eye axis revealed by multi-organ imaging genetics and proteomics. | MULTI Consortium et al. | β | 2025 | β |
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| Causal Analyses of Associations Between Brain Structure and Suicide Attempt in Adulthood and Late Childhood. | Zhou Y et al. | β | 2025 | β |
| CAUSALdb2: an updated database for causal variants of complex traits. | Wang J et al. | β | 2025 | β |
| Causal relationship between gastroesophageal reflux disease and 7 types of hernias: A bidirectional Mendelian randomization study. | Chen X et al. | β | 2025 | β |
| Causal relationships between inflammatory mediators, sleep traits, and cardiac magnetic resonance imaging-derived cardiac phenotypes. | Cao S et al. | β | 2025 | β |
| Causal relationships between white matter connectome and mental disorders: a large-scale genetic correlation study. | Zhao Z et al. | β | 2025 | β |
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| Comprehensive mapping of genetic variation at Epromoters reveals pleiotropic association with multiple disease traits. | Wan J et al. | β | 2025 | β |
| Comprehensive Multi-omics Analysis of Regulatory Variants for Body Weight in Cattle. | Niu ηηΎ€η Q et al. | β | 2025 | β |
| Computational analysis of congenital heart disease associated SNPs: unveiling their impact on the gene regulatory system. | Vashisht S et al. | β | 2025 | β |
| Conserved noncoding cis elements associated with hibernation modulate metabolic and behavioral adaptations in mice. | Steinwand S et al. | β | 2025 | β |
| Context-specific eQTLs provide deeper insight into causal genes underlying shared genetic architecture of COVID-19 and idiopathic pulmonary fibrosis. | Dalapati T et al. | β | 2025 | β |
| Correlation Analysis of Pyroptosis-Related Genes CASP1, NLRP3, AIM2, and NLRP1 With Lung Adenocarcinoma. | Zhu L et al. | β | 2025 | β |
| CRISPR-based functional genomics tools in vertebrate models. | Varshney GK et al. | β | 2025 | β |
| CUT&Tag recovers up to half of ENCODE ChIP-seq histone acetylation peaks. | Abbasova L et al. | β | 2025 | β |
| De novo variant analysis of childhood-onset obsessive-compulsive disorder in the French-Canadian population. | Bornais K et al. | β | 2025 | β |
| Discovery of Novel Pain Regulators Through Integration of Cross-Species High-Throughput Data. | Chen Y et al. | β | 2025 | β |
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| Distinct patterns of genetic overlap among multimorbidities revealed with trivariate MiXeR. | Shadrin AA et al. | β | 2025 | β |
| DMRdb: a disease-centric Mendelian randomization database for systematically assessing causal relationships of diseases with genes, proteins, CpG sites, metabolites and other diseases. | Zheng X et al. | β | 2025 | β |
| Egg-laying ChickenGTEx resource deciphers context-specific regulatory effects on fertility traits. | Zhu D et al. | β | 2025 | β |
| Exploiting pleiotropy to enhance variant discovery with functional false discovery rates. | Bass AJ et al. | β | 2025 | β |
| Exploring the genetic architecture of brain structure and ADHD using polygenic neuroimaging-derived scores. | van der Es T et al. | β | 2025 | β |
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| Functional Determinants and Evolutionary Consequences of Pleiotropy in Complex and Mendelian Traits. | Barbitoff YA et al. | β | 2025 | β |
| Generative prediction of causal gene sets responsible for complex traits. | Kuznets-Speck B et al. | β | 2025 | β |
| Genetic architecture of plasma metabolome in 254,825 individuals. | Qiang YX et al. | β | 2025 | β |
| Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohort. | Γ kerlund M et al. | β | 2025 | β |
| Genetic Correlates of Treatment-Resistant Depression. | Xu B et al. | β | 2025 | β |
| Genetic correlation, pleiotropic loci and shared risk genes between major depressive disorder and gastrointestinal tract disorders. | Zhou S et al. | β | 2025 | β |
| Genetic determinants of monocyte splicing are enriched for disease susceptibility loci. | Nassiri I et al. | β | 2025 | β |
| Genetic insights into cardiac conduction disorders from genome-wide association studies. | Li B et al. | β | 2025 | β |
| Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults. | Shi Y et al. | β | 2025 | β |
| Genetic Loci Associated with Nail Plate MorphologyΒ in East Asian Populations. | Ge J et al. | β | 2025 | β |
| Genetic, Transcriptomic, and Epigenomic Insights into SjΓΆgren's Disease: An Integrative Network Investigation and Immune Diseases Comparison. | Enduru N et al. | β | 2025 | β |
| Genetic variants associated with gout identified through a genome-wide study in the UK biobank (Nβ=β150β542). | Tao Y et al. | β | 2025 | β |
| Genome data based deep learning identified new genes predicting pharmacological treatment response of attention deficit hyperactivity disorder. | Zhao Y et al. | β | 2025 | β |
| Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania. | Xu ZM et al. | β | 2025 | β |
| Genome-wide analyses identify 30 loci associated with obsessive-compulsive disorder. | Strom NI et al. | β | 2025 | β |
| Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry. | Gui A et al. | β | 2025 | β |
| Genome-wide association study for lung cancer in 6531 African Americans reveals new susceptibility loci. | Byun J et al. | β | 2025 | β |
| Genome-wide association study identifies novel genetic variants associated with widespread pain in the UK Biobank (<i>N</i> = 172,230). | Pan Q et al. | β | 2025 | β |
| Genome-wide functional annotation of variants: a systematic review of state-of-the-art tools, techniques and resources. | Pilalis E et al. | β | 2025 | β |
| Genomic Characterisation of the Relationship and Causal Links Between Vascular Calcification, Alzheimer's Disease, and Cognitive Traits. | Adewuyi EO et al. | β | 2025 | β |
| Glucokinase Regulatory Protein as a Putative Target for Gestational Diabetes Mellitus and Related Complications: Evidence From the Mendelian Randomization Study. | Mao W et al. | β | 2025 | β |
| Gut Microbiota Metabolites Sensed by Host GPR41/43 Protect Against Hypertension. | R Muralitharan R et al. | β | 2025 | β |
| GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition. | Alex E et al. | β | 2025 | β |
| Haplotype analysis reveals pleiotropic disease associations in the HLA region. | Smith CJ et al. | β | 2025 | β |
| Heterogeneity of Acute Myeloid Leukemia patients explored through single-cell and single-sample gene regulatory networks. | Fernandes L et al. | β | 2025 | β |
| Identification and catalog of viral transcriptional regulators in human diseases. | Citu C et al. | β | 2025 | β |
| Identification of food deprivation in salmonids using gill biomarkers. | Bugg WS et al. | β | 2025 | β |
| Identification of Risk Genes for Attention-Deficit/Hyperactivity Disorder During Early Human Brain Development. | Deng MG et al. | β | 2025 | β |
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| Improving Machine Learning Prediction of ADHD Using Gene Set Polygenic Risk Scores and Risk Scores From Genetically Correlated Phenotypes. | Barnett EJ et al. | β | 2025 | β |
| Inferring multi-organ genetic connections using imaging and clinical data through Mendelian randomization. | Shu J et al. | β | 2025 | β |
| In silico prediction of variant effects: promises and limitations for precision plant breeding. | Sendrowski J et al. | β | 2025 | β |
| Integrating extensive functional annotations and multiomics of cattle enhances climate resilience prediction and mapping. | Xiang R et al. | β | 2025 | β |
| Integrative genetic analysis: cornerstone of precision psychiatry. | Vorstman J et al. | β | 2025 | β |
| Intergenerational transmission of polygenic predisposition for neuropsychiatric traits on emotional and behavioural difficulties in childhood. | Allegrini AG et al. | β | 2025 | β |
| Just a SNP away: The future of <i>in vivo</i> massively parallel reporter assay. | Degner KN et al. | β | 2025 | β |
| Large-scale GWAS of strabismus identifies risk loci and provides support for a link with maternal smoking. | He W et al. | β | 2025 | β |
| Local patterns of genetic sharing between neuropsychiatric and insulin resistance-related conditions. | Fanelli G et al. | β | 2025 | β |
| M2 Macrophages are Major Mediators of Germline Risk of Endometriosis and Explain Pleiotropy With Comorbid Traits. | Ochoa S et al. | β | 2025 | β |
| Mapping multitissue regulatory variants reveals a liver-centric coexpression network associated with duck egg-laying performance. | Xi Y et al. | β | 2025 | β |
| Mapping the Genetic Landscape of Psychiatric Disorders With the MiXeR Toolset. | van der Meer D et al. | β | 2025 | β |
| Mediating factors between autoimmune thyroiditis and breast cancer: a bidirectional Mendelian randomization study. | Xin P et al. | β | 2025 | β |
| Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus. | Perzel Mandell KA et al. | β | 2025 | β |
| metacp: a versatile software package for combining dependent or independent p-values. | Nikolitsa EK et al. | β | 2025 | β |
| Multi-omics integrated analysis identifies key biomarkers for hepatocellular carcinoma. | Xiong T et al. | β | 2025 | β |
| Multi-Trait Polygenic Risk Score, Nongenetic Determinants, and Cardiovascular Disease Death: A Cohort Study of 14β086 Japanese Individuals. | Fujii R et al. | β | 2025 | β |
| Multivariate genome-wide analysis reveals shared genetic architecture and brain structural correlates of human cognitive abilities. | Chen H et al. | β | 2025 | β |
| MUTATE: a human genetic atlas of multiorgan artificial intelligence endophenotypes using genome-wide association summary statistics. | Boquet-Pujadas A et al. | β | 2025 | β |
| Network construction using sparse Gaussian graphical model based on GWAS summary statistics. | Subedi M et al. | β | 2025 | β |
| Non-coding variation in dementias: mechanisms, insights, and challenges. | Rogers BB et al. | β | 2025 | β |
| Nonlinear association of TSH with pulmonary ventilation: insights from bidirectional Mendelian randomization and cross-sectional study. | Wang Y et al. | β | 2025 | β |
| Phenome-wide association study and functional annotation of hemoglobin A1c-associated variants in African populations. | Soremekun C et al. | β | 2025 | β |
| Phenome-wide investigation of dietary and health outcomes associated with bitter taste receptor gene TAS2R38. | Brito Nunes C et al. | β | 2025 | β |
| Physiological role and mechanisms of action for a long noncoding haplotype region. | Xue H et al. | β | 2025 | β |
| Pleiotropy increases parallel selection signatures during adaptation from standing genetic variation. | Lai WY et al. | β | 2025 | β |
| Polyconnectomic Scoring of Functional Connectivity Patterns Across Eight Neuropsychiatric and Three Neurodegenerative Disorders. | Libedinsky I et al. | β | 2025 | β |
| Polygenic predisposition to transdiagnostic symptom dimensions and treatment outcomes across psychiatric disorders. | Abondio P et al. | β | 2025 | β |
| Predicting expression-altering promoter mutations with deep learning. | Jaganathan K et al. | β | 2025 | β |
| Prediction of Skin Color Using Forensic DNA Phenotyping in Asian Populations: A Focus on Thailand. | Perez Palomeque G et al. | β | 2025 | β |
| PRED-LD: efficient imputation of GWAS summary statistics. | Manios GA et al. | β | 2025 | β |
| Preimplantation genetic testing for type 2 diabetes based on family-specific polygenic risk score: A proof-of-concept study. | Xu C et al. | β | 2025 | β |
| Prioritizing effector genes at trait-associated loci using multimodal evidence. | Schipper M et al. | β | 2025 | β |
| Quantitative trait loci mapping of circulating metabolites in cerebrospinal fluid to uncover biological mechanisms involved in brain-related phenotypes. | Reus LM et al. | β | 2025 | β |
| Realizing the promise of genome-wide association studies for effector gene prediction. | Costanzo MC et al. | β | 2025 | β |
| Rethinking GWAS: how lessons from genetic screens and artificial intelligence could reveal biological mechanisms. | Hazelett DJ | β | 2025 | β |
| sc2GWAS: a comprehensive platform linking single cell and GWAS traits of human. | Yin M et al. | β | 2025 | β |
| SC-VAR: a computational tool for interpreting polygenic disease risks using single-cell epigenomic data. | Zhao G et al. | β | 2025 | β |
| Shared Genetic Architecture Between Atopic Dermatitis and Autoimmune Diseases. | Lazanas P et al. | β | 2025 | β |
| Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets. | Dou C et al. | β | 2025 | β |
| Shedding Light on Antisocial Behavior Through Genetically Informed Research. | Pezzoli P et al. | β | 2025 | β |
| Simple scaling laws control the genetic architectures of human complex traits. | Simons YB et al. | β | 2025 | β |
| Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease. | Liu A et al. | β | 2025 | β |
| Sleep Disturbance in Parkinson's Disease: Consequences for the Brain and Disease Progression - A Narrative Review. | Anderson KN et al. | β | 2025 | β |
| Sparse matrix factorization robust to sample sharing across GWASs reveals interpretable genetic components. | Omdahl AR et al. | β | 2025 | β |
| Stratified shared genetic architecture of IBD and RA: an integrated analysis from polygenic overlap to directional heterogeneity. | Jia Y et al. | β | 2025 | β |
| Stratifying variant deleteriousness and trait-modulating effect under human recent adaptation using the FIND model. | Fan X et al. | β | 2025 | β |
| Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizophrenia. | Lu Z et al. | β | 2025 | β |
| The causal effect of smoking on psychiatric disorders: an examination of brain volume as a potential pathway. | van de Weijer MP et al. | β | 2025 | β |
| The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming. | Grimmett ZW et al. | β | 2025 | β |
| The emergence of genetic variants linked to brain and cognitive traits in human evolution. | Libedinsky I et al. | β | 2025 | β |
| The Emerging Role of the DDAH Proteins in Psychiatric Disorders. | Vareltzoglou MR et al. | β | 2025 | β |
| The genetic influence of sex on gene expression for blood in pigs. | Lin Q et al. | β | 2025 | β |
| The genetics of low and high birthweight and their relationship with cardiometabolic disease. | Moen GH et al. | β | 2025 | β |
| The health impacts and genetic architecture of food liking in cardio-metabolic diseases. | Jiang W et al. | β | 2025 | β |
| The Interplay Between Sleep and Mental Health: A Genetic Perspective. | Kozhemiako N et al. | β | 2025 | β |
| The role of NUDT3 in lipid accumulation and its functional variants related to backfat thickness in pigs. | An Y et al. | β | 2025 | β |
| The Trait Coding Rule in Phenotype Space. | Wang J et al. | β | 2025 | β |
| The trait-specific timing of accelerated genomic change in the human lineage. | Kun E et al. | β | 2025 | β |
| Transcriptomic signatures associated with developmental transitions in the gill of lake sturgeon (Acipenser fulvescens). | Bugg WS et al. | β | 2025 | β |
| Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men. | Janivara R et al. | β | 2025 | β |
| Unraveling shared genetics across asthma subtypes and 81 asthma-related traits. | Vernet R et al. | β | 2025 | β |
| Unveiling the genetic overlap and causal links between gastroesophageal reflux disease and asthma. | Zhang Y et al. | β | 2025 | β |
| Update on the genetics of allergic diseases. | Lawson LP et al. | β | 2025 | β |
| Using genomic context informed genotype data and within-model ancestry adjustment to classify type 2 diabetes. | Barnett EJ et al. | β | 2025 | β |
| Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study. | Tissink EP et al. | β | 2024 | β |
| A compendium of genetic regulatory effects across pig tissues. | Teng J et al. | β | 2024 | β |
| A comprehensive framework for trans-ancestry pathway analysis using GWAS summary data from diverse populations. | Fu S et al. | β | 2024 | β |
| A cross-disease, pleiotropy-driven approach for therapeutic target prioritization and evaluation. | Bao C et al. | β | 2024 | β |
| A distinct class of pan-cancer susceptibility genes revealed by an alternative polyadenylation transcriptome-wide association study. | Chen H et al. | β | 2024 | β |
| Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos. | Xia R et al. | β | 2024 | β |
| A genome-wide association study identifies candidate genes for sleep disturbances in depressed individuals. | Yang X et al. | β | 2024 | β |
| A genome-wide association study of social trust in 33,882 Danish blood donors. | Sequeros CB et al. | β | 2024 | β |
| A Genomics England haplotype reference panel and imputation of UK Biobank. | Shi S et al. | β | 2024 | β |
| A linear weighted combination of polygenic scores for a broad range of traits improves prediction of coronary heart disease. | Norland K et al. | β | 2024 | β |
| A modeling of complex trait phenotypic variance determinants. | Hussain S | β | 2024 | β |
| Analysis of Evolutionary Conservation, Expression Level, and Genetic Association at a Genome-wide Scale Reveals Heterogeneity Across Polygenic Phenotypes. | Giel AS et al. | β | 2024 | β |
| Ancestry-specific high-risk gene variant profiling unmasks diabetes-associated genes. | Zhang J et al. | β | 2024 | β |
| An integrated clinical approach to children at genetic risk for neurodevelopmental and psychiatric conditions: interdisciplinary collaboration and research infrastructure. | Summers J et al. | β | 2024 | β |
| A novel classification framework for genome-wide association study of whole brain MRI images using deep learning. | Yu S et al. | β | 2024 | β |
| A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. | Jennings MV et al. | β | 2024 | β |
| A review of the advances in understanding the genetic basis of spondylarthritis and emerging clinical benefit. | Stadler M et al. | β | 2024 | β |
| Association Between Circulating Vitamin K Levels, Gut Microbiome, and Type 1 Diabetes: A Mendelian Randomization Study. | De La Barrera S et al. | β | 2024 | β |
| Association between Psoriasis and Renal Functions: An Integration Study of Observational Study and Mendelian Randomization. | Tan Y et al. | β | 2024 | β |
| Association between rheumatoid arthritis and autoimmune thyroid disease: evidence from complementary genetic methods. | Liu X et al. | β | 2024 | β |
| Association between vitamin D metabolism gene polymorphisms and schizophrenia. | Shboul M et al. | β | 2024 | β |
| Associations Between General and Specific Mental Health Conditions in Young Adulthood and Cardiometabolic Complications in Middle Adulthood: A 40-Year Longitudinal Familial Coaggregation Study of 672,823 Swedish Individuals. | Chen C et al. | β | 2024 | β |
| Associations of measured and genetically predicted leukocyte telomere length with vascular phenotypes: a population-based study. | Liu D et al. | β | 2024 | β |
| A time-resolved multi-omics atlas of transcriptional regulation in response to high-altitude hypoxia across whole-body tissues. | Yan Z et al. | β | 2024 | β |
| A transcriptomic hourglass in brown algae. | Lotharukpong JS et al. | β | 2024 | β |
| Autistic traits in youth with familial adenomatous polyposis: A Dutch-Canadian case-control study. | Danieli PP et al. | β | 2024 | β |
| Bias and mean squared error in Mendelian randomization with invalid instrumental variables. | Deng L et al. | β | 2024 | β |
| Causal Associations of Sleep Apnea With Alzheimer Disease and Cardiovascular Disease: A Bidirectional Mendelian Randomization Analysis. | CavaillΓ¨s C et al. | β | 2024 | β |
| Causal relationships between diseases mined from the literature improve the use of polygenic risk scores. | Toonsi S et al. | β | 2024 | β |
| Competition Increases Risk of Species Extinction during Extreme Warming. | Walberg PB | β | 2024 | β |
| Considerations for the application of polygenic scores to clinical care of individuals with substance use disorders. | Kember RL et al. | β | 2024 | β |
| Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking. | Johnson EC et al. | β | 2024 | β |
| Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases. | Li C et al. | β | 2024 | β |
| CWAS-Plus: estimating category-wide association of rare noncoding variation from whole-genome sequencing data with cell-type-specific functional data. | Kim Y et al. | β | 2024 | β |
| Deciphering genetic characteristics of South China and North China indigenous pigs through selection signatures. | Gao Y et al. | β | 2024 | β |
| Deep learning for genomic selection of aquatic animals. | Wang Y et al. | β | 2024 | β |
| Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associations. | Ghatan S et al. | β | 2024 | β |
| Diagnosed eating disorders in Danish registers - incidence, prevalence, mortality, and polygenic risk. | Larsen JT et al. | β | 2024 | β |
| Digital tools of analysis and data integration facilitate synergy between mouse and human brain research and enable translation. | HΓΆlter SM et al. | β | 2024 | β |
| Disease-specific prioritization of non-coding GWAS variants based on chromatin accessibility. | Liang Q et al. | β | 2024 | β |
| Diverse signaling mechanisms and heterogeneity of astrocyte reactivity in Alzheimer's disease. | Qin H et al. | β | 2024 | β |
| Does co-localization analysis reinforce the results of Mendelian randomization? | Yin Q et al. | β | 2024 | β |
| Dual-trait genomic analysis in highly stratified Arabidopsis thaliana populations using genome-wide association summary statistics. | Feng X et al. | β | 2024 | β |
| Effects of immune cells in mediating the relationship between gut microbiota and myelodysplastic syndrome: a bidirectional two-sample, two-step Mendelian randomization study. | Feng Z et al. | β | 2024 | β |
| Effects of parental socioeconomic status on offspring's fetal neurodevelopment. | Mathan J et al. | β | 2024 | β |
| Eight quick tips for including chromosome X in genome-wide association studies. | Bellavance J et al. | β | 2024 | β |
| Enhanced bovine genome annotation through integration of transcriptomics and epi-transcriptomics datasets facilitates genomic biology. | Beiki H et al. | β | 2024 | β |
| Epigenome-wide association study of fluoride exposure during early adolescence and DNA methylation among U.S. children. | Ruehlmann AK et al. | β | 2024 | β |
| Epistasis and pleiotropy-induced variation for plant breeding. | Dwivedi SL et al. | β | 2024 | β |
| Evaluation of the Observational Associations and Shared Genetics Between Glaucoma With Depression and Anxiety. | Zhang X et al. | β | 2024 | β |
| Examination of a novel expression-based gene-SNP annotation strategy to identify tissue-specific contributions to heritability in multiple traits. | Mize TJ et al. | β | 2024 | β |
| Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood. | Breunig S et al. | β | 2024 | β |
| Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study. | Frach L et al. | β | 2024 | β |
| Examining the association between the FTO gene and neuroticism reveals indirect effects on subjective well-being and problematic alcohol use. | Cai W et al. | β | 2024 | β |
| Exploring the causal relationship between gut microbiota and multiple myeloma risk based on Mendelian randomization and biological annotation. | Feng Z et al. | β | 2024 | β |
| Exploring the intersection of polygenic risk scores and prenatal alcohol exposure: Unraveling the mental health equation. | Gerlikhman L et al. | β | 2024 | β |
| Exploring the Link between Oxidative Stress, Selenium Levels, and Obesity in Youth. | Bizerea-Moga TO et al. | β | 2024 | β |
| Functional and regulatory diversification of Period genes responsible for circadian rhythm in vertebrates. | Kwak JS et al. | β | 2024 | β |
| Gene co-expression network and differential expression analyses reveal key genes for weaning weight in Simmental-Holstein crossbred cattle. | Yan S et al. | β | 2024 | β |
| Genetic architecture distinguishes tinnitus from hearing loss. | Clifford RE et al. | β | 2024 | β |
| Genetic Architecture of Neurological Disorders and Their Endophenotypes: Insights from Genetic Association Studies. | Sargurupremraj M | β | 2024 | β |
| Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits. | Ge YJ et al. | β | 2024 | β |
| Genetic associations with disease in populations with Indigenous American ancestries. | VicuΓ±a L | β | 2024 | β |
| Genetic effects and causal association analyses of 14 common conditions/diseases in multimorbidity patterns. | Fu T et al. | β | 2024 | β |
| Genetic overlap and Mendelian randomization analysis highlighted the causal relationship between psoriatic disease and migraine. | Tan Y et al. | β | 2024 | β |
| Genetic overlap between Alzheimer's disease and immune-mediated diseases: an atlas of shared genetic determinants and biological convergence. | Enduru N et al. | β | 2024 | β |
| Genetic prediction of the relationship between metabolic syndrome and colorectal cancer risk: a Mendelian randomization study. | Yuan C et al. | β | 2024 | β |
| Genetic regulation of m<sup>6</sup>A RNA methylation and its contribution in human complex diseases. | Chen K et al. | β | 2024 | β |
| Genetics of flight in spongy moths (Lymantria dispar ssp.): functionally integrated profiling of a complex invasive trait. | Blackburn GS et al. | β | 2024 | β |
| Genome-wide analyses reveal shared genetic architecture and novel risk loci between opioid use disorder and general cognitive ability. | Holen B et al. | β | 2024 | β |
| Genome-wide association study of susceptibility to <i>Pseudomonas aeruginosa</i> infection in cystic fibrosis. | Lin B et al. | β | 2024 | β |
| Genome-wide cross-disease analyses highlight causality and shared biological pathways of type 2 diabetes with gastrointestinal disorders. | Adewuyi EO et al. | β | 2024 | β |
| Genome-Wide Genetic Analysis of Dropout in a Controlled Exercise Intervention in Sedentary Adults With Overweight or Obesity and Cardiometabolic Disease. | Jiang R et al. | β | 2024 | β |
| Genome-wide large-scale multi-trait analysis characterizes global patterns of pleiotropy and unique trait-specific variants. | Qi G et al. | β | 2024 | β |
| Genome-Wide Meta-analysis Identifies Risk Loci and Improves Disease Prediction of Age-Related Macular Degeneration. | He W et al. | β | 2024 | β |
| Genomic determinants, architecture, and constraints in drought-related traits in Corymbia calophylla. | Ahrens CW et al. | β | 2024 | β |
| GNN4DM: a graph neural network-based method to identify overlapping functional disease modules. | GΓ©zsi A et al. | β | 2024 | β |
| Haplotype function score improves biological interpretation and cross-ancestry polygenic prediction of human complex traits. | Song W et al. | β | 2024 | β |
| HiChIP-Based Epigenomic Footprinting Identifies a Promoter Variant of UXS1 That Confers Genetic Susceptibility to Gastroesophageal Cancer. | Gnanapragasam A et al. | β | 2024 | β |
| Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease. | Gao J et al. | β | 2024 | β |
| Human Leukocyte Antigen Signatures as Pathophysiological Discriminants of Microscopic Colitis Subtypes. | Zheng T et al. | β | 2024 | β |
| Identification of Causal Relationships between Gut Microbiota and Influenza a Virus Infection in Chinese by Mendelian Randomization. | Liao Q et al. | β | 2024 | β |
| Identification of genetic basis of brain imaging by group sparse multi-task learning leveraging summary statistics. | Xi D et al. | β | 2024 | β |
| Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders. | Tesfaye M et al. | β | 2024 | β |
| Identifying pleiotropic genes via the composite test amidst the complexity of polygenic traits. | Lai EY et al. | β | 2024 | β |
| <i>LRP1</i> Repression by SNAIL Results in ECM Remodeling in Genetic Risk for Vascular Diseases. | Liu L et al. | β | 2024 | β |
| Impact of gut microbiota on metabolic syndrome and its comprising traits: a two-sample mendelian randomization study. | Zhang Y et al. | β | 2024 | β |
| Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets. | Frei O et al. | β | 2024 | β |
| Improving on polygenic scores across complex traits using select and shrink with summary statistics (S4) and LDpred2. | Tyrer JP et al. | β | 2024 | β |
| Integrated Pleiotropic Gene Set Unveils Comorbidity Insights across Digestive Cancers and Other Diseases. | Wu X et al. | β | 2024 | β |
| Integrative multi-omics analysis of genomic, epigenomic, and metabolomics data leads to new insights for Attention-Deficit/Hyperactivity Disorder. | Hubers N et al. | β | 2024 | β |
| Integrative polygenic risk score improves the prediction accuracy of complex traits and diseases. | Truong B et al. | β | 2024 | β |
| Intellectual Disability and Behavioral Deficits Linked to CYFIP1 Missense Variants Disrupting Actin Polymerization. | Mariano V et al. | β | 2024 | β |
| Investigating the Bidirectional Association of Rheumatoid Arthritis and Thyroid Function: A Methodologic Assessment of Mendelian Randomization. | Tan Y et al. | β | 2024 | β |
| JASPER: Fast, powerful, multitrait association testing in structured samples gives insight on pleiotropy in gene expression. | Mbatchou J et al. | β | 2024 | β |
| Joint modeling of an outcome variable and integrated omics datasets using GLM-PO2PLS. | Gu Z et al. | β | 2024 | β |
| Joint regression analysis of multiple traits based on genetic relationships. | Buchardt AS et al. | β | 2024 | β |
| Linking the gut microbiome to host DNA methylation by a discovery and replication epigenome-wide association study. | Demirkan A et al. | β | 2024 | β |
| Local genetic correlation via knockoffs reduces confounding due to cross-trait assortative mating. | Ma S et al. | β | 2024 | β |
| Mapping drug biology to disease genetics to discover drug impacts on the human phenome. | Habib M et al. | β | 2024 | β |
| Medical and genetic correlates of long-term buprenorphine treatment in the electronic health records. | Niarchou M et al. | β | 2024 | β |
| Mendelian randomization analysis using GWAS and eQTL data to investigate the relationship between chronotype and neuropsychiatric disorders and their molecular basis. | Crinion S et al. | β | 2024 | β |
| Mendelian randomization: causal inference leveraging genetic data. | Chen LG et al. | β | 2024 | β |
| Molecular landscape of the overlap between Alzheimer's disease and somatic insulin-related diseases. | Ruisch IH et al. | β | 2024 | β |
| MR Corge: sensitivity analysis of Mendelian randomization based on the core gene hypothesis for polygenic exposures. | Zhang W et al. | β | 2024 | β |
| Multivariate genetic architecture reveals testosterone-driven sexual antagonism in contemporary humans. | Chakrabarty A et al. | β | 2024 | β |
| Network medicine-based epistasis detection in complex diseases: ready for quantum computing. | Hoffmann M et al. | β | 2024 | β |
| Neuronal MAPT expression is mediated by long-range interactions with cis-regulatory elements. | Rogers BB et al. | β | 2024 | β |
| Neuropsychiatric disorders, chronotype and sleep: A narrative review of GWAS findings and the application of Mendelian randomization to investigate causal relationships. | Crinion S et al. | β | 2024 | β |
| OmiGA: A Toolkit for Ultra-efficient Molecular Trait Analysis in Complex Populations | Teng J et al. | β | 2024 | β |
| OSGEP regulates islet Ξ²-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice. | Liu Y et al. | β | 2024 | β |
| Osteoarthritis as an Enhanceropathy: Gene Regulation in Complex Musculoskeletal Disease. | Roberts JB et al. | β | 2024 | β |
| Pathogen stimulations and immune cells synergistically affect the gene expression profile characteristics of porcine peripheral blood mononuclear cells. | Yang J et al. | β | 2024 | β |
| Pharmacogenomics Beyond Single Common Genetic Variants: The Way Forward. | Lauschke VM et al. | β | 2024 | β |
| Phenome-wide association study of population-differentiating genetic variants around gene <i>ACSL1</i>. | Yang S et al. | β | 2024 | β |
| PheWAS-based clustering of Mendelian Randomisation instruments reveals distinct mechanism-specific causal effects between obesity and educational attainment. | Darrous L et al. | β | 2024 | β |
| PigBiobank: a valuable resource for understanding genetic and biological mechanisms of diverse complex traits in pigs. | Zeng H et al. | β | 2024 | β |
| Pleiotropic expression quantitative trait loci are enriched in enhancers and transcription factor binding sites and impact more genes. | GonzΓ‘lez A et al. | β | 2024 | β |
| Pleiotropy, epistasis and the genetic architecture of quantitative traits. | Mackay TFC et al. | β | 2024 | β |
| Polygenic prediction of human longevity on the supposition of pervasive pleiotropy. | Jabalameli MR et al. | β | 2024 | β |
| Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder. | LaBianca S et al. | β | 2024 | β |
| Polygenic Risk Score, Cardiorespiratory Fitness, and Cardiometabolic Risk Factors: WASEDA'S Health Study. | Tanisawa K et al. | β | 2024 | β |
| Principal and independent genomic components of brain structure and function. | Oblong LM et al. | β | 2024 | β |
| Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study. | Choi E et al. | β | 2024 | β |
| Progressive melting of surface water and unequal discharge of different DOM components profoundly perturb soil biochemical cycling. | Hao Y et al. | β | 2024 | β |
| Quantitative omnigenic model discovers interpretable genome-wide associations. | RuΕΎiΔkovΓ‘ N et al. | β | 2024 | β |
| Quantitative trait locus mapping in placenta: A comparative study of chorionic villus and birth placenta. | Dieckmann L et al. | β | 2024 | β |
| RAVAR: a curated repository for rare variant-trait associations. | Cao C et al. | β | 2024 | β |
| Refining the scope of genetic influences on alcohol misuse through environmental stratification and gene-environment interaction. | Savage JE et al. | β | 2024 | β |
| Repeated global adaptation across plant species. | Nocchi G et al. | β | 2024 | β |
| Revealing novel genomic insights and therapeutic targets for juvenile idiopathic arthritis through omics. | Fan J et al. | β | 2024 | β |
| Rome III Criteria Capture Higher Irritable Bowel Syndrome SNP-Heritability and Highlight a Novel Genetic Link With Cardiovascular Traits. | Camargo Tavares L et al. | β | 2024 | β |
| Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations. | Capalbo A et al. | β | 2024 | β |
| Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens. | CocoΘ R et al. | β | 2024 | β |
| Semaphorin 6D tunes amygdalar circuits for emotional, metabolic, and inflammatory outputs. | Nakanishi Y et al. | β | 2024 | β |
| Shared Genetic Architectures between Coronary Artery Disease and Type 2 Diabetes Mellitus in East Asian and European Populations. | Li X et al. | β | 2024 | β |
| Similarities and differences between osteoarthritis and rheumatoid arthritis: insights from Mendelian randomization and transcriptome analysis. | Zhang Z et al. | β | 2024 | β |
| Single-cell analysis reveals the spatial-temporal expression of genes associated with esophageal malformations. | Maj C et al. | β | 2024 | β |
| Single-housing-induced islet epigenomic changes are related to polymorphisms in diabetic KK mice. | Nammo T et al. | β | 2024 | β |
| SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration. | Hartmann J et al. | β | 2024 | β |
| Sleep regulation and host genetics. | Odriozola A et al. | β | 2024 | β |
| Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics. | Spargo TP et al. | β | 2024 | β |
| Synaptic proteome perturbations after maternal immune activation: Identification of embryonic and adult hippocampal changes. | Yotova AY et al. | β | 2024 | β |
| The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function. | Zhang J et al. | β | 2024 | β |
| The contribution of silencer variants to human diseases. | Huang D et al. | β | 2024 | β |
| The genetic architecture of biological age in nine human organ systems. | Wen J et al. | β | 2024 | β |
| The genetic architecture of repeated local adaptation to climate in distantly related plants. | Whiting JR et al. | β | 2024 | β |
| The genetic architecture of the human hypothalamus and its involvement in neuropsychiatric behaviours and disorders. | Chen SD et al. | β | 2024 | β |
| The genetic regulation of the gastric transcriptome is associated with metabolic and obesity-related traits and diseases. | Koebbe LL et al. | β | 2024 | β |
| The goldmine of GWAS summary statistics: a systematic review of methods and tools. | Kontou PI et al. | β | 2024 | β |
| The metabolome-wide signature of major depressive disorder. | Jansen R et al. | β | 2024 | β |
| The Peritoneal Membrane and Its Role in Peritoneal Dialysis. | Morelle J et al. | β | 2024 | β |
| The Role of Endothelial Cells in Atherosclerosis: Insights from Genetic Association Studies. | Pepin ME et al. | β | 2024 | β |
| Transcriptome-wide association studies associated with Crohn's disease: challenges and perspectives. | Jia K et al. | β | 2024 | β |
| Trans-eQTL mapping in gene sets identifies network effects of genetic variants. | Wang L et al. | β | 2024 | β |
| Unveiling the molecular landscape of cognitive aging: insights from polygenic risk scores, DNA methylation, and gene expression. | Neto S et al. | β | 2024 | β |
| Whole exome sequencing identifies genetic markers of enterovirus susceptibility in East Asians. | Sung CC et al. | β | 2024 | β |
| Whole-exome sequencing in a Chinese sample provides preliminary evidence for the link between rare/low-frequency immune-related variants and early-onset schizophrenia. | Zhong Y et al. | β | 2024 | β |
| Yield of genetic association signals from genomes, exomes and imputation in the UK Biobank. | Gaynor SM et al. | β | 2024 | β |
| Accurate detection of shared genetic architecture from GWAS summary statistics in the small-sample context. | Willis TW et al. | β | 2023 | β |
| A Comprehensive Genomic Analysis of Chinese Indigenous Ningxiang Pigs: Genomic Breed Compositions, Runs of Homozygosity, and Beyond. | Yin S et al. | β | 2023 | β |
| A cross-species proteomic map reveals neoteny of human synapse development. | Wang L et al. | β | 2023 | β |
| Addressing the ethical and societal challenges posed by genome-wide association studies of behavioral and brain-related traits. | de Hemptinne MC et al. | β | 2023 | β |
| An atrial fibrillation-associated regulatory region modulates cardiac <i>Tbx5</i> levels and arrhythmia susceptibility. | Bosada FM et al. | β | 2023 | β |
| An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping. | Wang Z et al. | β | 2023 | β |
| A phenome-wide scan reveals convergence of common and rare variant associations. | Zhou D et al. | β | 2023 | β |
| Are two beneficial mutations (p.Q249R and 90-bp Indel) within the ovine <i>BMPRIB</i> gene associated with growth traits? | Xu H et al. | β | 2023 | β |
| A scalable approach to characterize pleiotropy across thousands of human diseases and complex traits using GWAS summary statistics. | Zhang Z et al. | β | 2023 | β |
| Association between NTRK2 Polymorphisms, Hippocampal Volumes and Treatment Resistance in Major Depressive Disorder. | Paolini M et al. | β | 2023 | β |
| Association between sleep duration and metabolic syndrome: linear and nonlinear Mendelian randomization analyses. | Liang YY et al. | β | 2023 | β |
| Association Between Systemic Lupus Erythematosus and Primary Hypothyroidism: Evidence from Complementary Genetic Methods. | Liu X et al. | β | 2023 | β |
| A Transcriptome-Wide Analysis of Psoriasis: Identifying the Potential Causal Genes and Drug Candidates. | Jeong Y et al. | β | 2023 | β |
| Benchmarking of local genetic correlation estimation methods using summary statistics from genome-wide association studies. | Zhang C et al. | β | 2023 | β |
| Bivariate quantitative Bayesian LASSO for detecting association of rare haplotypes with two correlated continuous phenotypes. | Sajal IH et al. | β | 2023 | β |
| Brain Catalog: a comprehensive resource for the genetic landscape of brain-related traits. | Pan S et al. | β | 2023 | β |
| Characterization of large-scale genomic differences in the first complete human genome. | Yang X et al. | β | 2023 | β |
| Circulating Inflammatory Cytokines and Female Reproductive Diseases: A Mendelian Randomization Analysis. | Lin Y et al. | β | 2023 | β |
| Cis-meQTL for cocaine use-associated DNA methylation in an HIV-positive cohort show pleiotropic effects on multiple traits. | Cheng Y et al. | β | 2023 | β |
| Common Variants on <i>FGD5</i> Increase Hazard of Mortality or Rehospitalization in Patients With Heart Failure From the ASCEND-HF Trial. | Gui H et al. | β | 2023 | β |
| Comparative three-dimensional genome architectures of adipose tissues provide insight into human-specific regulation of metabolic homeostasis. | Liu P et al. | β | 2023 | β |
| Confronting ethical and social issues related to the genetics of musicality. | Gordon RL et al. | β | 2023 | β |
| Contemplating syndromic autism. | Vorstman JAS et al. | β | 2023 | β |
| Convergence of Brain Transcriptomic and Neuroimaging Patterns in Schizophrenia, Bipolar Disorder, Autism Spectrum Disorder, and Major Depressive Disorder. | Ardesch DJ et al. | β | 2023 | β |
| Cross-ancestry analyses identify new genetic loci associated with 25-hydroxyvitamin D. | Wang X et al. | β | 2023 | β |
| Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies. | Waszczuk MA et al. | β | 2023 | β |
| Dissecting the cross-trait effects of the FOXP2 GWAS hit on clinical and brain phenotypes in adults with ADHD. | Meyer GP et al. | β | 2023 | β |
| Dissecting the high-resolution genetic architecture of complex phenotypes by accurately estimating gene-based conditional heritability. | Miao L et al. | β | 2023 | β |
| Elucidating the patterns of pleiotropy and its biological relevance in maize. | Khaipho-Burch M et al. | β | 2023 | β |
| Epidemiologic and Genetic Associations of Endometriosis With Depression, Anxiety, and Eating Disorders. | Koller D et al. | β | 2023 | β |
| Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation. | Kotsakis Ruehlmann A et al. | β | 2023 | β |
| Examining the shared etiology of psychopathology with genome-wide association studies. | Mallard TT et al. | β | 2023 | β |
| Exome-based new allele-specific PCR markers and transferability for sodicity tolerance in bread wheat (<i>Triticum aestivum</i> L.). | Bhoite R et al. | β | 2023 | β |
| Exome-wide analysis reveals role of <i>LRP1</i> and additional novel loci in cognition. | Chakraborty S et al. | β | 2023 | β |
| Explainable multi-task learning improves the parallel estimation of polygenic risk scores for many diseases through shared genetic basis. | BadrΓ© A et al. | β | 2023 | β |
| Exploring the mechanism of artificial selection signature in Chinese indigenous pigs by leveraging multiple bioinformatics database tools. | Feng X et al. | β | 2023 | β |
| Functional Variation in the <i>FAAH</i> Gene Is Directly Associated with Subjective Well-Being and Indirectly Associated with Problematic Alcohol Use. | Bornscheuer L et al. | β | 2023 | β |
| GCPBayes pipeline: a tool for exploring pleiotropy at theΒ gene level. | Asgari Y et al. | β | 2023 | β |
| Genetic architecture of terpene chemistry and growth traits and the impact of inbreeding on these traits in western redcedar (<i>Thuja plicata</i>). | Shalev TJ et al. | β | 2023 | β |
| Genetic Association Analysis of Copy Number Variations for Meat Quality in Beef Cattle. | Wu J et al. | β | 2023 | β |
| Genetic basis of STEM occupational choice and regional economic performance: a UK biobank genome-wide association study. | Zhu C et al. | β | 2023 | β |
| Genetic contributions to transdiagnostic symptom dimensions in patients with major depressive disorder, bipolar disorder, and schizophrenia spectrum disorders. | David FS et al. | β | 2023 | β |
| Genetic correlation and gene-based pleiotropy analysis for four major neurodegenerative diseases with summary statistics. | Qiao J et al. | β | 2023 | β |
| Genetic differences according to onset age and lung function in asthma: A cluster analysis. | Kim HK et al. | β | 2023 | β |
| Genetic liability to posttraumatic stress disorder and its association with postpartum depression. | Bang Madsen K et al. | β | 2023 | β |
| Genetic nurture versus genetic transmission of risk for ADHD traits in the Norwegian Mother, Father and Child Cohort Study. | Pingault JB et al. | β | 2023 | β |
| Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling. | Zorina-Lichtenwalter K et al. | β | 2023 | β |
| Genetics and mechanisms of thoracic aortic disease. | Chou E et al. | β | 2023 | β |
| Genetics implicates overactive osteogenesis in the development of diffuse idiopathic skeletal hyperostosis. | Sethi A et al. | β | 2023 | β |
| Genome Editing and Heart Failure. | Masarone D et al. | β | 2023 | β |
| Genome-wide analyses reveal novel opioid use disorder loci and genetic overlap with schizophrenia, bipolar disorder, and major depression. | Holen B et al. | β | 2023 | β |
| Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders. | Yao X et al. | β | 2023 | β |
| Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci. | Jaholkowski P et al. | β | 2023 | β |
| Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits. | Mocci E et al. | β | 2023 | β |
| Genome-wide association studies: utility and limitations for research in physiology. | Pereira Ciochetti N et al. | β | 2023 | β |
| Genome-wide association study of antisocial personality disorder diagnostic criteria provides evidence for shared risk factors across disorders. | Li W et al. | β | 2023 | β |
| Genome-Wide Association Study of Chronic Dizziness in the Elderly Identifies Loci Implicating MLLT10, BPTF, LINC01224, and ROS1. | Clifford R et al. | β | 2023 | β |
| Genome-Wide Association Study of Pericardial Fat Area in 28β161 UK Biobank Participants. | Salih A et al. | β | 2023 | β |
| [Genome-wide studies of comorbidity of somatic and mental diseases]. | Golimbet VE et al. | β | 2023 | β |
| Germline mechanisms of immunotherapy toxicities in the era of genome-wide association studies. | Gusev A | β | 2023 | β |
| GSEL: a fast, flexible python package for detecting signatures of diverse evolutionary forces on genomic regions. | Abraham A et al. | β | 2023 | β |
| GWAS Atlas: an updated knowledgebase integrating more curated associations in plants and animals. | Liu X et al. | β | 2023 | β |
| GWASs Identify Genetic Loci Associated with Human Scalp Hair Whorl Direction. | Luo J et al. | β | 2023 | β |
| Human genetic adaptation related to cellular zinc homeostasis. | Roca-Umbert A et al. | β | 2023 | β |
| Human height: a model common complex trait. | Conery M et al. | β | 2023 | β |
| Human subsistence and signatures of selection on chemosensory genes. | Veilleux CC et al. | β | 2023 | β |
| Identification of the causal relationship between sleep quality, insomnia, and oral ulcers. | Liu Q et al. | β | 2023 | β |
| Identifying Genetic Architecture of Carcass and Meat Quality Traits in a Ningxiang Indigenous Pig Population. | Yin S et al. | β | 2023 | β |
| [Immune mechanisms of complicity of somatic pathology in the pathogenesis of mental disorders]. | Klyushnik TP et al. | β | 2023 | β |
| Influence of glycoprotein MUC1 on trafficking of the Ca<sup>2+</sup>-selective ion channels, TRPV5 and TRPV6, and on inΒ vivo calcium homeostasis. | Al-Bataineh MM et al. | β | 2023 | β |
| Influencing cognitive performance via social interactions: a novel therapeutic approach for brain disorders based on neuroanatomical mapping? | Lanooij SD et al. | β | 2023 | β |
| Integrative analyses for the identification of idiopathic pulmonary fibrosis-associated genes and shared loci with other diseases. | Chen M et al. | β | 2023 | β |
| Integrative Functional Genomics Identifies Systemic Lupus Erythematosus Causal Genetic Variant in the IRF5 Risk Locus. | Hou G et al. | β | 2023 | β |
| Integrative mapping of the dog epigenome: Reference annotation for comparative intertissue and cross-species studies. | Son KH et al. | β | 2023 | β |
| Integrative Multi-omics Analysis of Childhood Aggressive Behavior. | Hagenbeek FA et al. | β | 2023 | β |
| Investigating the shared genetic architecture of post-traumatic stress disorder and gastrointestinal tract disorders: a genome-wide cross-trait analysis. | Zhou S et al. | β | 2023 | β |
| Investigation of convergent and divergent genetic influences underlying schizophrenia and alcohol use disorder. | Johnson EC et al. | β | 2023 | β |
| Investigation of heteroscedasticity in polygenic risk scores across 15 quantitative traits. | Jung H et al. | β | 2023 | β |
| Large epigenome-wide association study identifies multiple novel differentially methylated CpG sites associated with suicidal thoughts and behaviors in veterans. | Kimbrel NA et al. | β | 2023 | β |
| Leveraging epigenomes and three-dimensional genome organization for interpreting regulatory variation. | Baur B et al. | β | 2023 | β |
| Leveraging Single-Cell Populations to Uncover the Genetic Basis of Complex Traits. | Minow MAA et al. | β | 2023 | β |
| Localization Pattern of Dispatched Homolog 2 (DISP2) in the Central and Enteric Nervous System. | Heimke M et al. | β | 2023 | β |
| Machine Learning to Advance Human Genome-Wide Association Studies. | Sigala RE et al. | β | 2023 | β |
| Mapping genomic regulation of kidney disease and traits through high-resolution and interpretable eQTLs. | Han SK et al. | β | 2023 | β |
| Mapping microRNA expression quantitative trait loci in the prenatal human brain implicates miR-1908-5p expression in bipolar disorder and other brain-related traits. | Toste CC et al. | β | 2023 | β |
| Mendelian randomization study of gastroesophageal reflux disease and major depression. | Zheng X et al. | β | 2023 | β |
| Meta-analysis of African ancestry genome-wide association studies identified novel locus and validates multiple loci associated with kidney function. | Kintu C et al. | β | 2023 | β |
| Metabolic Overlap between Alzheimer's Disease and Metabolic Syndrome Identifies the <i>PVRL2</i> Gene as a New Modulator of Diabetic Dyslipidemia. | Guardiola M et al. | β | 2023 | β |
| MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size. | Lafferty MJ et al. | β | 2023 | β |
| Misguided model of human behavior: Comment on C. H. Burt: "Challenging the utility of polygenic scores for social scienceβ¦". | Richardson K | β | 2023 | β |
| Mitochondrial related genome-wide Mendelian randomization identifies putatively causal genes for multiple cancer types. | Li Y et al. | β | 2023 | β |
| Modeling of horizontal pleiotropy identifies possible causal gene expression in systemic lupus erythematosus. | Chepelev I et al. | β | 2023 | β |
| Molecular bases of comorbidities: present and future perspectives. | SΓ‘nchez-Valle J et al. | β | 2023 | β |
| MTMR3 risk alleles enhance Toll Like Receptor 9-induced IgA immunity in IgA nephropathy. | Wang YN et al. | β | 2023 | β |
| Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration. | Scammell BH et al. | β | 2023 | β |
| Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings. | Dapas M et al. | β | 2023 | β |
| Multi-PGS enhances polygenic prediction by combining 937 polygenic scores. | AlbiΓ±ana C et al. | β | 2023 | β |
| Network expansion of genetic associations defines a pleiotropy map of human cell biology. | Barrio-Hernandez I et al. | β | 2023 | β |
| New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications. | Andreassen OA et al. | β | 2023 | β |
| New statistical selection method for pleiotropic variants associated with both quantitative and qualitative traits. | Kim K et al. | β | 2023 | β |
| Novel Functional Genomics Approaches Bridging Neuroscience and Psychiatry. | Restrepo-Lozano JM et al. | β | 2023 | β |
| On the interpretation of transcriptome-wide association studies. | de Leeuw C et al. | β | 2023 | β |
| Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer's Disease-Related Biomarkers. | Schork NJ et al. | β | 2023 | β |
| Patterns and evolutionary consequences of pleiotropy. | Zhang J | β | 2023 | β |
| Pleiotropic influence of DNA methylation QTLs on physiological and ageing traits. | Mozhui K et al. | β | 2023 | β |
| Polygenic architecture of rare coding variation across 394,783 exomes. | Weiner DJ et al. | β | 2023 | β |
| Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia. | O'Connell KS et al. | β | 2023 | β |
| Polygenic risk scores and brain structures both contribute to externalizing behavior in childhood - A study in the Adolescent Brain and Cognitive Development (ABCD) cohort. | Teeuw J et al. | β | 2023 | β |
| Postpartum and non-postpartum depression: a population-based matched case-control study comparing polygenic risk scores for severe mental disorders. | Munk-Olsen T et al. | β | 2023 | β |
| PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome. | Mu L et al. | β | 2023 | β |
| Predicting Heterogeneity in Patient Response to Morphine Treatment for Neonatal Opioid Withdrawal Syndrome. | Smolyak D et al. | β | 2023 | β |
| Projecting genetic associations through gene expression patterns highlights disease etiology and drug mechanisms. | Pividori M et al. | β | 2023 | β |
| Rare and Common Variants in GALNT3 May Affect Bone Mass Independently of Phosphate Metabolism. | Hassan N et al. | β | 2023 | β |
| Recent natural selection conferred protection against schizophrenia by non-antagonistic pleiotropy. | GonzΓ‘lez-PeΓ±as J et al. | β | 2023 | β |
| Recent positive selection signatures reveal phenotypic evolution in the Han Chinese population. | Luo H et al. | β | 2023 | β |
| Refining patterns of MEF2C effects in white matter microstructure and psychiatric features. | de Araujo Tavares ME et al. | β | 2023 | β |
| Rheumatoid arthritis and hypothyroidism: a bidirectional Mendelian randomization study. | Duan L et al. | β | 2023 | β |
| Robust identification of regulatory variants (eQTLs) using a differential expression framework developed for RNA-sequencing. | Marrella MA et al. | β | 2023 | β |
| Robustness of quantifying mediating effects of genetically regulated expression on complex traits with mediated expression score regression. | Lin C et al. | β | 2023 | β |
| Role of the Gut-Brain Axis in the Shared Genetic Etiology Between Gastrointestinal Tract Diseases and Psychiatric Disorders: A Genome-Wide Pleiotropic Analysis. | Gong W et al. | β | 2023 | β |
| Shared genetic architecture between irritable bowel syndrome and psychiatric disorders reveals molecular pathways of the gut-brain axis. | Tesfaye M et al. | β | 2023 | β |
| SLCO5A1 and synaptic assembly genes contribute to impulsivity in juvenile myoclonic epilepsy. | Roshandel D et al. | β | 2023 | β |
| Summary statistics-based association test for identifying the pleiotropic effects with set of genetic variants. | Bu D et al. | β | 2023 | β |
| Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control. | Gunasekara CJ et al. | β | 2023 | β |
| The Genetically Informed Neurobiology of Addiction (GINA) model. | Bogdan R et al. | β | 2023 | β |
| The Genetic Architectures of Functional and Structural Connectivity Properties within Cerebral Resting-State Networks. | Tissink E et al. | β | 2023 | β |
| The genetic overlap between Alzheimer's disease, amyotrophic lateral sclerosis, Lewy body dementia, and Parkinson's disease. | Wightman DP et al. | β | 2023 | β |
| The interactions between host genome and gut microbiome increase the risk of psychiatric disorders: Mendelian randomization and biological annotation. | Xiao L et al. | β | 2023 | β |
| The role of claudins in homeostasis. | Meoli L et al. | β | 2023 | β |
| Trans-Acting Genotypes Associated with mRNA Expression Affect Metabolic and Thermal Tolerance Traits. | Drown MK et al. | β | 2023 | β |
| TWAS Atlas: a curated knowledgebase of transcriptome-wide association studies. | Lu M et al. | β | 2023 | β |
| Using human genetics to improve safety assessment of therapeutics. | Carss KJ et al. | β | 2023 | β |
| xQTLbiolinks: a comprehensive and scalable tool for integrative analysis of molecular QTLs. | Ding R et al. | β | 2023 | β |
| Zebrafish regulatory genomic resources for disease modelling and regeneration. | Jimenez Gonzalez A et al. | β | 2023 | β |
| Advances in profiling chromatin architecture shed light on the regulatory dynamics underlying brain disorders. | Pratt BM et al. | β | 2022 | β |
| Age differences in diffusivity in the locus coeruleus and its ascending noradrenergic tract. | Porat S et al. | β | 2022 | β |
| A genome-wide association study of serum proteins reveals shared loci with common diseases. | Gudjonsson A et al. | β | 2022 | β |
| A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndrome. | Skuladottir AT et al. | β | 2022 | β |
| A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer's disease and gastrointestinal tract disorders. | Adewuyi EO et al. | β | 2022 | β |
| A Mendelian Randomization Study of the Effect of Tea Intake on Type 2 Diabetes. | Zhang Y et al. | β | 2022 | β |
| A metabolic associated fatty liver disease risk variant in MBOAT7 regulates toll like receptor induced outcomes. | Alharthi J et al. | β | 2022 | β |
| A multi-omics study of circulating phospholipid markers of blood pressure. | Liu J et al. | β | 2022 | β |
| An integrated framework for local genetic correlation analysis. | Werme J et al. | β | 2022 | β |
| A pleiotropic hypoxia-sensitive <i>EPAS1</i> enhancer is disrupted by adaptive alleles in Tibetans. | Gray OA et al. | β | 2022 | β |
| Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer. | Wade KH et al. | β | 2022 | β |
| Associations between psychiatric polygenic risk scores and general and specific psychopathology symptoms in childhood and adolescence between and within dizygotic twin pairs. | Chen C et al. | β | 2022 | β |
| A summary-statistics-based approach to examine the role of serotonin transporter promoter tandem repeat polymorphism in psychiatric phenotypes. | Majumdar A et al. | β | 2022 | β |
| Biobanking as a Tool for Genomic Research: From Allele Frequencies to Cross-Ancestry Association Studies. | Lazareva TE et al. | β | 2022 | β |
| Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology. | van der Meer D et al. | β | 2022 | β |
| Challenges and Opportunities for Developing More Generalizable Polygenic Risk Scores. | Wang Y et al. | β | 2022 | β |
| Characterizing the polygenic overlaps of bipolar disorder subtypes with schizophrenia and major depressive disorder. | Li Z et al. | β | 2022 | β |
| Collective genomic segments with differential pleiotropic patterns between cognitive dimensions and psychopathology. | Lam M et al. | β | 2022 | β |
| Comparative transcriptome in large-scale human and cattle populations. | Yao Y et al. | β | 2022 | β |
| Complementary Experimental Methods in Genetics Open Up New Avenues of Research to Elucidate the Pathogenesis of Periodontitis. | Schaefer AS | β | 2022 | β |
| Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models. | Dejanovic B et al. | β | 2022 | β |
| Concerns about the use of polygenic embryo screening for psychiatric and cognitive traits. | Lencz T et al. | β | 2022 | β |
| Corticolimbic DCC gene co-expression networks as predictors of impulsivity in children. | Restrepo-Lozano JM et al. | β | 2022 | β |
| Cross-Disorder Analysis of Shared Genetic Components Between Cortical Structures and Major Psychiatric Disorders. | Li Z et al. | β | 2022 | β |
| Deconstructing a Syndrome: Genomic Insights Into PCOS Causal Mechanisms and Classification. | Dapas M et al. | β | 2022 | β |
| Deep phenotyping for precision medicine in Parkinson's disease. | Schalkamp AK et al. | β | 2022 | β |
| Demystifying non-coding GWAS variants: an overview of computational tools and methods. | Schipper M et al. | β | 2022 | β |
| Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations. | Koller D et al. | β | 2022 | β |
| Diet X Gene Interactions Control Femoral Bone Adaptation to Low Dietary Calcium. | Chanpaisaeng K et al. | β | 2022 | β |
| Differences in the genetic architecture of common and rare variants in childhood, persistent and late-diagnosed attention-deficit hyperactivity disorder. | Rajagopal VM et al. | β | 2022 | β |
| Discerning asthma endotypes through comorbidity mapping. | Jia G et al. | β | 2022 | β |
| Disentangling Genetic Risks for Metabolic Syndrome. | van Walree ES et al. | β | 2022 | β |
| Dissecting the shared genetic basis of migraine and mental disorders using novel statistical tools. | Bahrami S et al. | β | 2022 | β |
| Diverse functions associate with non-coding polymorphisms shared between humans and chimpanzees. | Velazquez-Arcelay K et al. | β | 2022 | β |
| DNA methylation in peripheral tissues and left-handedness. | Odintsova VV et al. | β | 2022 | β |
| Drug repurposing candidates to treat core symptoms in autism spectrum disorder. | Koch E et al. | β | 2022 | β |
| Editorial: Genetic Pleiotropy in Complex Traits and Diseases. | Xu Q et al. | β | 2022 | β |
| Effect of host genetics on the gut microbiome in 7,738 participants of the Dutch Microbiome Project. | Lopera-Maya EA et al. | β | 2022 | β |
| Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information. | Maihofer AX et al. | β | 2022 | β |
| Epigenome-wide association study of alcohol use disorder in five brain regions. | Zillich L et al. | β | 2022 | β |
| Epigenomics of rats' liver and its cross-species functional annotation reveals key regulatory genes underlying short term heat-stress response. | Dou J et al. | β | 2022 | β |
| eQTLs as causal instruments for the reconstruction of hormone linked gene networks. | Bankier S et al. | β | 2022 | β |
| Evaluating brain structure traits as endophenotypes using polygenicity and discoverability. | Matoba N et al. | β | 2022 | β |
| Evaluating the role of rare genetic variation in sleep duration. | Meng P et al. | β | 2022 | β |
| Exploratory analysis of multi-trait coadaptations in light of population history. | Nakamichi R et al. | β | 2022 | β |
| Exploring potential shared genetic influences between rheumatoid arthritis and blood lipid levels. | Kasher M et al. | β | 2022 | β |
| Exploring the association between birthweight and breast cancer using summary statistics from a perspective of genetic correlation, mediation, and causality. | Zhang M et al. | β | 2022 | β |
| Exploring the genetic overlap between twelve psychiatric disorders. | Romero C et al. | β | 2022 | β |
| Functional network motifs defined through integration of protein-protein and genetic interactions. | Sahoo A et al. | β | 2022 | β |
| Functional Validation of Osteoporosis Genetic Findings Using Small Fish Models. | Kague E et al. | β | 2022 | β |
| Gene expression changes following chronic antipsychotic exposure in single cells from mouse striatum. | Abrantes A et al. | β | 2022 | β |
| Genetically Determined Low-Density Lipoprotein Cholesterol and Risk of Subarachnoid Hemorrhage. | Acosta JN et al. | β | 2022 | β |
| Genetic architecture and genomic predictive ability of apple quantitative traits across environments. | Jung M et al. | β | 2022 | β |
| Genetic architecture of 11 major psychiatric disorders at biobehavioral, functional genomic and molecular genetic levels of analysis. | Grotzinger AD et al. | β | 2022 | β |
| Genetic correlates of phenotypic heterogeneity in autism. | Warrier V et al. | β | 2022 | β |
| Genetic evidence supports the development of SLC26A9 targeting therapies for the treatment of lung disease. | Gong J et al. | β | 2022 | β |
| Genetic evidence that the causal association of educational attainment with reduced risk of Alzheimer's disease is driven by intelligence. | Thorp JG et al. | β | 2022 | β |
| Genetic Markers of Atopic Dermatitis Risk for Screening Aviation Applicants. | Gregory ID et al. | β | 2022 | β |
| Genetic risk factors have a substantial impact on healthy life years. | Jukarainen S et al. | β | 2022 | β |
| Genetics of adaptation. | Bomblies K et al. | β | 2022 | β |
| Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies. | Camilleri M et al. | β | 2022 | β |
| Genetic testing of dogs predicts problem behaviors in clinical and nonclinical samples. | Zapata I et al. | β | 2022 | β |
| Genetic variants associated with longitudinal changes in brain structure across the lifespan. | Brouwer RM et al. | β | 2022 | β |
| Genetic variants in CYP2B6 and HSD17B12 associated with risk of squamous cell carcinoma of the head and neck. | Liu H et al. | β | 2022 | β |
| Genome-wide analyses of platinum-induced ototoxicity in childhood cancer patients: Results of GO-CAT and United Kingdom MAGIC consortia. | Hurkmans EGE et al. | β | 2022 | β |
| Genome-wide analysis reveals genetic overlap between alcohol use behaviours, schizophrenia and bipolar disorder and identifies novel shared risk loci. | WistrΓΆm ED et al. | β | 2022 | β |
| Genome-wide association meta-analyses identify novel genetic risk loci and polygenic phenotype associations for heroin, methamphetamine and alcohol dependences. | Chang SH et al. | β | 2022 | β |
| Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health. | Tissink E et al. | β | 2022 | β |
| Genome-wide association study of musical beat synchronization demonstrates high polygenicity. | Niarchou M et al. | β | 2022 | β |
| Genome-wide identification of the shared genetic basis of cannabis and cigarette smoking and schizophrenia implicates NCAM1 and neuronal abnormality. | Song W et al. | β | 2022 | β |
| Genome-Wide Integration of Genetic and Genomic Studies of Atopic Dermatitis: Insights into Genetic Architecture and Pathogenesis. | Chen Y et al. | β | 2022 | β |
| Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways. | Watanabe K et al. | β | 2022 | β |
| Genomic architecture of phenotypic extremes in a wild cervid. | Anderson SJ et al. | β | 2022 | β |
| GWAS and autoimmunity: What have we learned and what next. | Gerussi A et al. | β | 2022 | β |
| Heterozygosity and homozygosity regions affect reproductive success and the loss of reproduction: A case study with litter traits in pigs. | Chen Z et al. | β | 2022 | β |
| Identification of a pleiotropic effect of ADIPOQ on cardiac dysfunction and Alzheimer's disease based on genetic evidence and health care records. | Paik H et al. | β | 2022 | β |
| Identification of blood metabolites linked to the risk of cholelithiasis: a comprehensive Mendelian randomization study. | Mi J et al. | β | 2022 | β |
| Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups. | Mattheisen M et al. | β | 2022 | β |
| Identification of Transcription Factor Networks during Mouse Hindlimb Development. | Wang M et al. | β | 2022 | β |
| Identifying pleiotropic genes for complex phenotypes with summary statistics from a perspective of composite null hypothesis testing. | Wang T et al. | β | 2022 | β |
| Identifying shared genetic loci between coronavirus disease 2019 and cardiovascular diseases based on cross-trait meta-analysis. | Guo H et al. | β | 2022 | β |
| Incorporating genome-wide and transcriptome-wide association studies to identify genetic elements of longissimus dorsi muscle in Huaxi cattle. | Liang M et al. | β | 2022 | β |
| Integrative Identification of Genetic Loci Jointly Influencing Diabetes-Related Traits and Sleep Traits of Insomnia, Sleep Duration, and Chronotypes. | Ma Y et al. | β | 2022 | β |
| Integrative transcriptome-wide analysis of atopic dermatitis for drug repositioning. | Song J et al. | β | 2022 | β |
| Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders. | Zhang X et al. | β | 2022 | β |
| Leveraging pleiotropic association using sparse group variable selection in genomics data. | Sutton M et al. | β | 2022 | β |
| Leveraging the local genetic structure for trans-ancestry association mapping. | Xiao J et al. | β | 2022 | β |
| Locus-level antagonistic selection shaped the polygenic architecture of human complex diseases. | Song W et al. | β | 2022 | β |
| Major Depressive Disorder: Existing Hypotheses about Pathophysiological Mechanisms and New Genetic Findings. | Kamran M et al. | β | 2022 | β |
| MEF2C gene variations are associated with ADHD in the Chinese Han population: a case-control study. | Fu X et al. | β | 2022 | β |
| Mendelian randomization for causal inference accounting for pleiotropy and sample structure using genome-wide summary statistics. | Hu X et al. | β | 2022 | β |
| Mendelian randomization in blood metabolites identifies triglycerides and fatty acids saturation level as associated traits linked to pancreatitis risk. | Mi J et al. | β | 2022 | β |
| Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals. | Strom NI et al. | β | 2022 | β |
| mGWAS-Explorer: Linking SNPs, Genes, Metabolites, and Diseases for Functional Insights. | Chang L et al. | β | 2022 | β |
| Mosaic patterns of selection in genomic regions associated with diverse human traits. | Abraham A et al. | β | 2022 | β |
| Multimodal biomedical AI. | Acosta JN et al. | β | 2022 | β |
| Multi-omics signatures of alcohol use disorder in the dorsal and ventral striatum. | Zillich L et al. | β | 2022 | β |
| Multiple-trait analyses improved the accuracy of genomic prediction and the power of genome-wide association of productivity and climate change-adaptive traits in lodgepole pine. | Cappa EP et al. | β | 2022 | β |
| Multivariate genomic and transcriptomic determinants of imaging-derived personalized therapeutic needs in Parkinson's disease. | Lenglos C et al. | β | 2022 | β |
| Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities. | Mallard TT et al. | β | 2022 | β |
| Multivariate, region-based genetic analyses of facets of reproductive aging in White and Black women. | Bielak LF et al. | β | 2022 | β |
| Network reconstruction for trans acting genetic loci using multi-omics data and prior information. | Hawe JS et al. | β | 2022 | β |
| New Insights on Gene by Environmental Effects of Drugs of Abuse in Animal Models Using GeneNetwork. | Chunduri A et al. | β | 2022 | β |
| Novel loci and potential mechanisms of major depressive disorder, bipolar disorder, and schizophrenia. | Wang H et al. | β | 2022 | β |
| Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance. | Greco LA et al. | β | 2022 | β |
| PCGA: a comprehensive web server for phenotype-cell-gene association analysis. | Xue C et al. | β | 2022 | β |
| PGS-server: accuracy, robustness and transferability of polygenic score methods for biobank scale studies. | Yang S et al. | β | 2022 | β |
| Physiological Genomics Plays a Crucial Role in Response to Stressful Life Events, the Development of Aggressive Behaviours, and Post-Traumatic Stress Disorder (PTSD). | Magwai T et al. | β | 2022 | β |
| PiER: web-based facilities tailored for genetic target prioritisation harnessing human disease genetics, functional genomics and protein interactions. | Fang H | β | 2022 | β |
| Pleiotropic Enhancers are Ubiquitous Regulatory Elements in the Human Genome. | Laiker I et al. | β | 2022 | β |
| Pleiotropic genetic architecture and novel loci for C-reactive protein levels. | Koskeridis F et al. | β | 2022 | β |
| Polygenic risk score for embryo selection-not ready for prime time. | Polyakov A et al. | β | 2022 | β |
| Prenatal exposure to phthalates and peripheral blood and buccal epithelial DNA methylation in infants: An epigenome-wide association study. | England-Mason G et al. | β | 2022 | β |
| Psychiatric manifestations of rare variation in medically actionable genes: a PheWAS approach. | Feng YA et al. | β | 2022 | β |
| Psychological factors as the risk factor of mouth ulcers: A two-sample Mendelian randomization study. | Shi Y et al. | β | 2022 | β |
| Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway. | Garnish SE et al. | β | 2022 | β |
| Reduced reproductive success is associated with selective constraint on human genes. | Gardner EJ et al. | β | 2022 | β |
| Relationship of Cognition and Alzheimer's Disease with Gastrointestinal Tract Disorders: A Large-Scale Genetic Overlap and Mendelian Randomisation Analysis. | Adewuyi EO et al. | β | 2022 | β |
| Repurposing Drugs via Network Analysis: Opportunities for Psychiatric Disorders. | Truong TTT et al. | β | 2022 | β |
| Research Review: A guide to computing and implementing polygenic scores in developmental research. | Allegrini AG et al. | β | 2022 | β |
| Revisiting the malaria hypothesis: accounting for polygenicity and pleiotropy. | Ebel ER et al. | β | 2022 | β |
| Robust inference of bi-directional causal relationships in presence of correlated pleiotropy with GWAS summary data. | Xue H et al. | β | 2022 | β |
| Schizophrenia and Macroscale Brain Structure: Genes in Context. | Hettwer MD et al. | β | 2022 | β |
| Shared components of heritability across genetically correlated traits. | Ballard JL et al. | β | 2022 | β |
| Sparse dictionary learning recovers pleiotropy from human cell fitness screens. | Pan J et al. | β | 2022 | β |
| Statistical methods for Mendelian randomization in genome-wide association studies: A review. | Boehm FJ et al. | β | 2022 | β |
| Strong and weak cross-inheritance of substance use disorders in a nationally representative sample. | Zhang H et al. | β | 2022 | β |
| Systems genetics in the rat HXB/BXH family identifies Tti2 as a pleiotropic quantitative trait gene for adult hippocampal neurogenesis and serum glucose. | Senko AN et al. | β | 2022 | β |
| Ten challenges for clinical translation in psychiatric genetics. | Derks EM et al. | β | 2022 | β |
| Test of Prosody via Syllable Emphasis ("TOPsy"): Psychometric Validation of a Brief Scalable Test of Lexical Stress Perception. | Nayak S et al. | β | 2022 | β |
| The Boechera model system for evolutionary ecology. | Rushworth CA et al. | β | 2022 | β |
| The CADM2 Gene and Behavior: A Phenome-Wide Scan in UK-Biobank. | Pasman JA et al. | β | 2022 | β |
| The cannabinoid receptor-1 gene interacts with stressful life events to increase the risk for problematic alcohol use. | Bornscheuer L et al. | β | 2022 | β |
| The individual and global impact of copy-number variants on complex human traits. | Auwerx C et al. | β | 2022 | β |
| The Musical Abilities, Pleiotropy, Language, and Environment (MAPLE) Framework for Understanding Musicality-Language Links Across the Lifespan. | Nayak S et al. | β | 2022 | β |
| The regulatory network architecture of cardiometabolic diseases. | Schmidt HHHW et al. | β | 2022 | β |
| Thirty novel sequence variants impacting human intracranial volume. | Nawaz MS et al. | β | 2022 | β |
| Three assays for in-solution enrichment of ancient human DNA at more than a million SNPs. | Rohland N et al. | β | 2022 | β |
| Uncovering the genetic architecture of broad antisocial behavior through a genome-wide association study meta-analysis. | Tielbeek JJ et al. | β | 2022 | β |
| Using Stem Cell Models to Explore the Genetics Underlying Psychiatric Disorders: Linking Risk Variants, Genes, and Biology in Brain Disease. | Brennand KJ | β | 2022 | β |
| XPXP: improving polygenic prediction by cross-population and cross-phenotype analysis. | Xiao J et al. | β | 2022 | β |
| ACE2 Netlas: <i>In silico</i> Functional Characterization and Drug-Gene Interactions of <i>ACE2</i> Gene Network to Understand Its Potential Involvement in COVID-19 Susceptibility. | Pathak GA et al. | β | 2021 | β |
| A Comprehensive Evaluation of Cross-Omics Blood-Based Biomarkers for Neuropsychiatric Disorders. | Song W et al. | β | 2021 | β |
| A comprehensive gene-centric pleiotropic association analysis for 14 psychiatric disorders with GWAS summary statistics. | Lu H et al. | β | 2021 | β |
| A cross-population atlas of genetic associations for 220 human phenotypes. | Sakaue S et al. | β | 2021 | β |
| Action detection using a neural network elucidates the genetics of mouse grooming behavior. | Geuther BQ et al. | β | 2021 | β |
| Advancing the use of genome-wide association studies for drug repurposing. | Reay WR et al. | β | 2021 | β |
| A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo. | Skuladottir AT et al. | β | 2021 | β |
| A global overview of genetically interpretable multimorbidities among common diseases in the UK Biobank. | Dong G et al. | β | 2021 | β |
| Alcohol and cigarette smoking consumption as genetic proxies for alcohol misuse and nicotine dependence. | Sanchez-Roige S et al. | β | 2021 | β |
| A meta-analysis uncovers the first sequence variant conferring risk of Bell's palsy. | Skuladottir AT et al. | β | 2021 | β |
| A Multilayer Interactome Network Constructed in a Forest Poplar Population Mediates the Pleiotropic Control of Complex Traits. | Gong H et al. | β | 2021 | β |
| Ancestry may confound genetic machine learning: Candidate-gene prediction of opioid use disorder as an example. | Hatoum AS et al. | β | 2021 | β |
| An iterative approach to detect pleiotropy and perform Mendelian Randomization analysis using GWAS summary statistics. | Zhu X et al. | β | 2021 | β |
| A Novel Method for Mendelian Randomization Analyses With Pleiotropy and Linkage Disequilibrium in Genetic Variants From Individual Data. | Wang Y et al. | β | 2021 | β |
| A Novel Precision Approach to Overcome the "Addiction Pandemic" by Incorporating Genetic Addiction Risk Severity (GARS) and Dopamine Homeostasis Restoration. | Blum K et al. | β | 2021 | β |
| A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density. | Sinnott-Armstrong N et al. | β | 2021 | β |
| A selection pressure landscape for 870 human polygenic traits. | Song W et al. | β | 2021 | β |
| A single-cell atlas of chromatin accessibility in the human genome. | Zhang K et al. | β | 2021 | β |
| Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals: Findings From the RHDGen Study. | Machipisa T et al. | β | 2021 | β |
| Association Study among Comethylation Modules, Genetic Polymorphisms and Clinical Features in Mexican Teenagers with Eating Disorders: Preliminary Results. | Nolasco-Rosales GA et al. | β | 2021 | β |
| A Transcriptome Community-and-Module Approach of the Human Mesoconnectome. | Paredes O et al. | β | 2021 | β |
| A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts. | Veturi Y et al. | β | 2021 | β |
| Bayesian meta-analysis models for cross cancer genomic investigation of pleiotropic effects using group structure. | Baghfalaki T et al. | β | 2021 | β |
| Bench Research Informed by GWAS Results. | Kondratyev NV et al. | β | 2021 | β |
| Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction. | Kim DJ et al. | β | 2021 | β |
| Chromatin architecture provides a roadmap to improve our understanding of psychiatric disorders. | Hu B et al. | β | 2021 | β |
| Comprehensive transcriptome and methylome analysis delineates the biological basis of hair follicle development and wool-related traits in Merino sheep. | Zhao B et al. | β | 2021 | β |
| Computational Tools for Causal Inference in Genetics. | Richardson TG et al. | β | 2021 | β |
| Constrained maximum likelihood-based Mendelian randomization robust to both correlated and uncorrelated pleiotropic effects. | Xue H et al. | β | 2021 | β |
| CYP11B1 variants influence skeletal maturation via alternative splicing. | Grgic O et al. | β | 2021 | β |
| Decoding disease: from genomes to networks to phenotypes. | Wong AK et al. | β | 2021 | β |
| Discordant associations of educational attainment with ASD and ADHD implicate a polygenic form of pleiotropy. | Verhoef E et al. | β | 2021 | β |
| Disentangling selection on genetically correlated polygenic traits via whole-genome genealogies. | Stern AJ et al. | β | 2021 | β |
| Dissecting polygenic signals from genome-wide association studies on human behaviour. | Abdellaoui A et al. | β | 2021 | β |
| Ditching candidate gene association studies: lessons from psychiatric genetics. | Duarte RRR et al. | β | 2021 | β |
| Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption. | KarabegoviΔ I et al. | β | 2021 | β |
| Evaluation of Genotype-Based Gene Expression Model Performance: A Cross-Framework and Cross-Dataset Study. | Tavares V et al. | β | 2021 | β |
| Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits. | Martin J et al. | β | 2021 | β |
| Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of <i>IRX3</i> and <i>IRX5</i>. | Sobreira DR et al. | β | 2021 | β |
| External visible characteristics prediction through SNPs analysis in the forensic setting: a review. | Tozzo P et al. | β | 2021 | β |
| Functionathon: a manual data mining workflow to generate functional hypotheses for uncharacterized human proteins and its application by undergraduate students. | Duek P et al. | β | 2021 | β |
| Gaining insight into metabolic diseases from human genetic discoveries. | Claussnitzer M et al. | β | 2021 | β |
| Genetic analyses identify widespread sex-differential participation bias. | Pirastu N et al. | β | 2021 | β |
| Genetic association and causal inference converge on hyperglycaemia as a modifiable factor to improve lung function. | Reay WR et al. | β | 2021 | β |
| Genetic association study of childhood aggression across raters, instruments, and age. | Ip HF et al. | β | 2021 | β |
| Genetic, Clinical, and Sociodemographic Factors Associated With Stimulant Treatment Outcomes in ADHD. | Brikell I et al. | β | 2021 | β |
| Genetic contributions to alcohol use disorder treatment outcomes: a genome-wide pharmacogenomics study. | Biernacka JM et al. | β | 2021 | β |
| Genetic correlates of socio-economic status influence the pattern of shared heritability across mental health traits. | Marees AT et al. | β | 2021 | β |
| Genetics of substance use disorders in the era of big data. | Gelernter J et al. | β | 2021 | β |
| Genome-wide analyses of behavioural traits are subject to bias by misreports and longitudinal changes. | Xue A et al. | β | 2021 | β |
| Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease. | Zheng T et al. | β | 2021 | β |
| Genome-wide association and selective sweep analyses reveal genetic loci for FCR of egg production traits in ducks. | Liu H et al. | β | 2021 | β |
| Genome-Wide Association Study Identifies Genetic Risk Factors for Spastic Cerebral Palsy. | Hale AT et al. | β | 2021 | β |
| Genome-wide association study of psychiatric and substance use comorbidity in Mexican individuals. | MartΓnez-MagaΓ±a JJ et al. | β | 2021 | β |
| Heritability Enrichment of Immunoglobulin G N-Glycosylation in Specific Tissues. | Li X et al. | β | 2021 | β |
| Heritability of sleep duration and quality: A systematic review and meta-analysis. | Kocevska D et al. | β | 2021 | β |
| Higher polygenic risk scores for schizophrenia may be suggestive of treatment non-response in major depressive disorder. | Fanelli G et al. | β | 2021 | β |
| Highly pleiotropic variants of human traits are enriched in genomic regions with strong background selection. | Novo I et al. | β | 2021 | β |
| <i>In vivo</i> and <i>in vitro</i> human gene essentiality estimations capture contrasting functional constraints. | Caldu-Primo JL et al. | β | 2021 | β |
| Immune-Mediated Drug-Induced Liver Injury: Immunogenetics and Experimental Models. | Gerussi A et al. | β | 2021 | β |
| Increased Menopausal Age Reduces the Risk of Parkinson's Disease: A Mendelian Randomization Approach. | Kusters CDJ et al. | β | 2021 | β |
| Integrating disease and drug-related phenotypes for improved identification of pharmacogenomic variants. | Ouellette TW et al. | β | 2021 | β |
| Integration of a single-step genome-wide association study with a multi-tissue transcriptome analysis provides novel insights into the genetic basis of wool and weight traits in sheep. | Zhao B et al. | β | 2021 | β |
| Integrative approaches generate insights into the architecture of non-syndromic cleft lip with or without cleft palate. | Welzenbach J et al. | β | 2021 | β |
| Investigating cytosolic 5'-nucleotidase II family genes as candidates for neuropsychiatric disorders in Drosophila (114/150 chr). | Singgih EL et al. | β | 2021 | β |
| Joint Analysis of Genetic Correlation, Mendelian Randomization and Colocalization Highlights the Bi-Directional Causal Association Between Hypothyroidism and Primary Biliary Cirrhosis. | Wang Y et al. | β | 2021 | β |
| Joint disease-specificity at the regulatory base-pair level. | Muthuirulan P et al. | β | 2021 | β |
| Large-scale association analyses identify host factors influencing human gut microbiome composition. | Kurilshikov A et al. | β | 2021 | β |
| Linking the genomic signatures of human beat synchronization and learned song in birds. | Gordon RL et al. | β | 2021 | β |
| Lossless integration of multiple electronic health records for identifying pleiotropy using summary statistics. | Li R et al. | β | 2021 | β |
| Magnitude of Mendelian versus complex inheritance of rare disorders. | Chakravarti A | β | 2021 | β |
| Maintenance of Complex Trait Variation: Classic Theory and Modern Data. | Koch EM et al. | β | 2021 | β |
| Major Depressive Disorder and Lifestyle: Correlated Genetic Effects in Extended Twin Pedigrees. | Huider F et al. | β | 2021 | β |
| MEDTEC Students against Coronavirus: Investigating the Role of Hemostatic Genes in the Predisposition to COVID-19 Severity. | Cappadona C et al. | β | 2021 | β |
| Mendelian randomisation highlights hypothyroidism as a causal determinant of idiopathic pulmonary fibrosis. | Zhang Y et al. | β | 2021 | β |
| Mendelian randomization and pleiotropy analysis. | Zhu X | β | 2021 | β |
| Mendelian Randomization Highlights the Causal Role of Normal Thyroid Function on Blood Lipid Profiles. | Wang Y et al. | β | 2021 | β |
| Metabolic Aspects of Adenosine Functions in the Brain. | Garcia-Gil M et al. | β | 2021 | β |
| Multi-environment gene interactions linked to the interplay between polysubstance dependence and suicidality. | Polimanti R et al. | β | 2021 | β |
| Multi-trait association studies discover pleiotropic loci between Alzheimer's disease and cardiometabolic traits. | Bone WP et al. | β | 2021 | β |
| Multitrait GWAS to connect disease variants and biological mechanisms. | Julienne H et al. | β | 2021 | β |
| Multivariate analysis reveals shared genetic architecture of brain morphology and human behavior. | de Vlaming R et al. | β | 2021 | β |
| Natural selection contributes to the myopia epidemic. | Long E et al. | β | 2021 | β |
| Natural variation in the regulation of neurodevelopmental genes modifies flight performance in Drosophila. | Spierer AN et al. | β | 2021 | β |
| Nontrivial Replication of Loci Detected by Multi-Trait Methods. | Ning Z et al. | β | 2021 | β |
| Parameterized algorithms for identifying gene co-expression modules via weighted clique decomposition. | Cooley M et al. | β | 2021 | β |
| Penalized partial least squares for pleiotropy. | Broc C et al. | β | 2021 | β |
| Phenome-wide and expression quantitative trait locus associations of coronavirus disease 2019 genetic risk loci. | Moon CY et al. | β | 2021 | β |
| Phenome-wide investigation of the causal associations between childhood BMI and adult trait outcomes: a two-sample Mendelian randomization study. | Dong SS et al. | β | 2021 | β |
| Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study. | Bahls M et al. | β | 2021 | β |
| PLEIO: a method to map and interpret pleiotropic loci with GWAS summary statistics. | Lee CH et al. | β | 2021 | β |
| Pleiotropy and Cross-Disorder Genetics Among Psychiatric Disorders. | Lee PH et al. | β | 2021 | β |
| Pleiotropy or linkage? Their relative contributions to the genetic correlation of quantitative traits and detection by multitrait GWA studies. | Chebib J et al. | β | 2021 | β |
| Polygenic basis and biomedical consequences of telomere length variation. | Codd V et al. | β | 2021 | β |
| Populations, Traits, and Their Spatial Structure in Humans. | Sohail M et al. | β | 2021 | β |
| Posttraumatic Stress Disorder and Cardiovascular Disease: State of the Science, Knowledge Gaps, and Research Opportunities. | O'Donnell CJ et al. | β | 2021 | β |
| Problems with Using Polygenic Scores to Select Embryos. | Turley P et al. | β | 2021 | β |
| Protective Roles of Folic Acid in the Responses of Bovine Mammary Epithelial Cells to Different Virulent <i>Staphylococcus aureus</i> Strains. | Mi S et al. | β | 2021 | β |
| Proteome-wide Systems Genetics to Identify Functional Regulators of Complex Traits. | Molendijk J et al. | β | 2021 | β |
| Quantifying the contribution of Neanderthal introgression to the heritability of complex traits. | McArthur E et al. | β | 2021 | β |
| Reproducibility in the UK biobank of genome-wide significant signals discovered in earlier genome-wide association studies. | O'Sullivan JW et al. | β | 2021 | β |
| Rhythm and timing as vulnerabilities in neurodevelopmental disorders. | Lense MD et al. | β | 2021 | β |
| Serum Uric Acid Levels and Risk of Eight Site-Specific Cancers: A Mendelian Randomization Study. | Jiang M et al. | β | 2021 | β |
| Shared genetic architecture across psychiatric disorders. | Grotzinger AD | β | 2021 | β |
| Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease. | Shadrin AA et al. | β | 2021 | β |
| snpXplorer: a web application to explore human SNP-associations and annotate SNP-sets. | Tesi N et al. | β | 2021 | β |
| Symptom-level modelling unravels the shared genetic architecture of anxiety and depression. | Thorp JG et al. | β | 2021 | β |
| The Causal Effects of Primary Biliary Cholangitis on Thyroid Dysfunction: A Two-Sample Mendelian Randomization Study. | Huang P et al. | β | 2021 | β |
| The evolutionary biology of endometriosis. | Dinsdale N et al. | β | 2021 | β |
| The evolution of group differences in changing environments. | Harpak A et al. | β | 2021 | β |
| The genetic architecture and population genomic signatures of glyphosate resistance in Amaranthus tuberculatus. | Kreiner JM et al. | β | 2021 | β |
| The genomic history of the Middle East. | Almarri MA et al. | β | 2021 | β |
| The impact of cell type and context-dependent regulatory variants on human immune traits. | Mu Z et al. | β | 2021 | β |
| The molecular basis, genetic control and pleiotropic effects of local gene co-expression. | Ribeiro DM et al. | β | 2021 | β |
| The predictive capacity of psychiatric and psychological polygenic risk scores for distinguishing cases in a child and adolescent psychiatric sample from controls. | Jansen AG et al. | β | 2021 | β |
| The role of glucocorticoid receptor gene in the association between attention deficit-hyperactivity disorder and smaller brain structures. | Bandeira CE et al. | β | 2021 | β |
| Topologically associating domain boundaries that are stable across diverse cell types are evolutionarily constrained and enriched for heritability. | McArthur E et al. | β | 2021 | β |
| Total genetic contribution assessment across the human genome. | Li T et al. | β | 2021 | β |
| Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits. | Zhao B et al. | β | 2021 | β |
| Two-Sample Multivariable Mendelian Randomization Analysis Using R. | Rasooly D et al. | β | 2021 | β |
| Utility of polygenic embryo screening for disease depends on the selection strategy. | Lencz T et al. | β | 2021 | β |
| Variants in NEB and RIF1 genes on chr2q23 are associated with skeletal muscle index in Koreans: genome-wide association study. | Yoon KJ et al. | β | 2021 | β |
| Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology. | Shadrin AA et al. | β | 2021 | β |
| What can we learn from common variants associated with unexpected phenotypes in rare genetic diseases? | Erdmann J | β | 2021 | β |
| Widespread signatures of natural selection across human complex traits and functional genomic categories. | Zeng J et al. | β | 2021 | β |
| Accurate and Scalable Construction of Polygenic Scores in Large Biobank Data Sets. | Yang S et al. | β | 2020 | β |
| Adaptation via pleiotropy and linkage: Association mapping reveals a complex genetic architecture within the stickleback <i>Eda</i> locus. | Archambeault SL et al. | β | 2020 | β |
| Adaptive selection drives TRPP3 loss-of-function in an Ethiopian population. | Walsh S et al. | β | 2020 | β |
| A Data-Driven Review of the Genetic Factors of Pregnancy Complications. | Barbitoff YA et al. | β | 2020 | β |
| A large-scale genome-wide association study meta-analysis of cannabis use disorder. | Johnson EC et al. | β | 2020 | β |
| An Exposure-Wide and Mendelian Randomization Approach to Identifying Modifiable Factors for the Prevention of Depression. | Choi KW et al. | β | 2020 | β |
| A powerful method for pleiotropic analysis under composite null hypothesis identifies novel shared loci between Type 2 Diabetes and Prostate Cancer. | Ray D et al. | β | 2020 | β |
| AraPheno and the AraGWAS Catalog 2020: a major database update including RNA-Seq and knockout mutation data for Arabidopsis thaliana. | Togninalli M et al. | β | 2020 | β |
| A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD-Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis. | Gregson CL et al. | β | 2020 | β |
| CAUSALdb: a database for disease/trait causal variants identified using summary statistics of genome-wide association studies. | Wang J et al. | β | 2020 | β |
| Cognitive Genomics: Recent Advances and Current Challenges. | Fitzgerald J et al. | β | 2020 | β |
| Common schizophrenia risk variants are enriched in open chromatin regions of human glutamatergic neurons. | Hauberg ME et al. | β | 2020 | β |
| Comprehensive analyses of 723 transcriptomes enhance genetic and biological interpretations for complex traits in cattle. | Fang L et al. | β | 2020 | β |
| Convergent Evidence for Predispositional Effects of Brain Gray Matter Volume on Alcohol Consumption. | Baranger DAA et al. | β | 2020 | β |
| CUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption. | Chen IC et al. | β | 2020 | β |
| Effect direction meta-analysis of GWAS identifies extreme, prevalent and shared pleiotropy in a large mammal. | Xiang R et al. | β | 2020 | β |
| Evolutionary medical insights into the SARS-CoV-2 pandemic. | Crespi B | β | 2020 | β |
| Facilitating Complex Trait Analysis via Reduced Complexity Crosses. | Bryant CD et al. | β | 2020 | β |
| From genome-wide association studies to rational drug target prioritisation in inflammatory arthritis. | Fang H et al. | β | 2020 | β |
| Gene mapping and functional annotation of GWAS of oral ulcers using FUMA software. | Jin X et al. | β | 2020 | β |
| Gene Networks Driving Genetic Variation in Milk and Cheese-Making Traits of Spanish Assaf Sheep. | Marina H et al. | β | 2020 | β |
| Genetic Variants in Lipid Metabolism Pathways Interact with Diet to Influence Blood Lipid Concentrations in Adults with Overweight and Obesity. | Hannon BA et al. | β | 2020 | β |
| Genetic Variation and Response to Neurocritical Illness: a Powerful Approach to Identify Novel Pathophysiological Mechanisms and Therapeutic Targets. | Acosta JN et al. | β | 2020 | β |
| Genome-wide association and multi-omic analyses reveal ACTN2 as a gene linked to heart failure. | Arvanitis M et al. | β | 2020 | β |
| Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors. | Bakker MK et al. | β | 2020 | β |
| Genomics at cellular resolution: insights into cognitive disorders and their evolution. | Berto S et al. | β | 2020 | β |
| Identification of <i>slit3</i> as a locus affecting nicotine preference in zebrafish and human smoking behaviour. | GarcΓa-GonzΓ‘lez J et al. | β | 2020 | β |
| Identifying blood pressure loci whose effects are modulated by multiple lifestyle exposures. | Osazuwa-Peters OL et al. | β | 2020 | β |
| Impute.me: An Open-Source, Non-profit Tool for Using Data From Direct-to-Consumer Genetic Testing to Calculate and Interpret Polygenic Risk Scores. | Folkersen L et al. | β | 2020 | β |
| Inferring causal direction between two traits in the presence of horizontal pleiotropy with GWAS summary data. | Xue H et al. | β | 2020 | β |
| Is atypical rhythm a risk factor for developmental speech and language disorders? | LadΓ‘nyi E et al. | β | 2020 | β |
| JASS: command line and web interface for the joint analysis of GWAS results. | Julienne H et al. | β | 2020 | β |
| Leveraging existing GWAS summary data of genetically correlated and uncorrelated traits to improve power for a new GWAS. | Xue H et al. | β | 2020 | β |
| Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium. | Polimanti R et al. | β | 2020 | β |
| Marker Selection in Multivariate Genomic Prediction Improves Accuracy of Low Heritability Traits. | KlΓ‘pΕ‘tΔ J et al. | β | 2020 | β |
| Molecular genetics in psychology and personality neuroscience: On candidate genes, genome wide scans, and new research strategies. | Montag C et al. | β | 2020 | β |
| Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes. | Perrino PA et al. | β | 2020 | β |
| Multi-trait analysis of rare-variant association summary statistics using MTAR. | Luo L et al. | β | 2020 | β |
| Neurofibromatosis Type 1 Implicates Ras Pathways in the Genetic Architecture of Neurodevelopmental Disorders. | Kaczorowski JA et al. | β | 2020 | β |
| Patterns of sociocognitive stratification and perinatal risk in the child brain. | AlnΓ¦s D et al. | β | 2020 | β |
| Phenome-wide functional dissection of pleiotropic effects highlights key molecular pathways for human complex traits. | Shikov AE et al. | β | 2020 | β |
| PhenomeXcan: Mapping the genome to the phenome through the transcriptome. | Pividori M et al. | β | 2020 | β |
| Phosphoproteomic quantitation and causal analysis reveal pathways in GPVI/ITAM-mediated platelet activation programs. | Babur Γ et al. | β | 2020 | β |
| Polygenic Scores for Height in Admixed Populations. | Bitarello BD et al. | β | 2020 | β |
| Polygenic Scores in Developmental Psychology: Invite Genetics In, Leave Biodeterminism Behind. | Raffington L et al. | β | 2020 | β |
| Population genomics of the Viking world. | Margaryan A et al. | β | 2020 | β |
| Population variation in miRNAs and isomiRs and their impact on human immunity to infection. | Rotival M et al. | β | 2020 | β |
| Preimplantation Genetic Testing for Polygenic Disease Relative Risk Reduction: Evaluation of Genomic Index Performance in 11,883 Adult Sibling Pairs. | Treff NR et al. | β | 2020 | β |
| Psoriasis and Genetics. | Dand N et al. | β | 2020 | β |
| Quantifying the Polygenic Architecture of the Human Cerebral Cortex: Extensive Genetic Overlap between Cortical Thickness and Surface Area. | van der Meer D et al. | β | 2020 | β |
| sn-spMF: matrix factorization informs tissue-specific genetic regulation of gene expression. | He Y et al. | β | 2020 | β |
| Statistical Impact of Sample Size and Imbalance on Multivariate Analysis <i>in silico</i> and A Case Study in the UK Biobank. | Zhang X et al. | β | 2020 | β |
| The Musculoskeletal Knowledge Portal: Making Omics Data Useful to the Broader Scientific Community. | Kiel DP et al. | β | 2020 | β |
| The polygenic architecture of schizophrenia - rethinking pathogenesis and nosology. | Smeland OB et al. | β | 2020 | β |
| The support of genetic evidence for cardiovascular risk induced by antineoplastic drugs. | Cui H et al. | β | 2020 | β |
| Transcriptome Analysis of Maternal Gene Transcripts in Unfertilized Eggs of <i>Misgurnus anguillicaudatus</i> and Identification of Immune-Related Maternal Genes. | Kim CH et al. | β | 2020 | β |
| Transcriptome profiling in adult attention-deficit hyperactivity disorder. | Mortimer N et al. | β | 2020 | β |
| Translating insights from neuropsychiatric genetics and genomics for precision psychiatry. | Rees E et al. | β | 2020 | β |
| Understanding polygenic models, their development and the potential application of polygenic scores in healthcare. | Babb de Villiers C et al. | β | 2020 | β |
| Understanding the genetic determinants of the brain with MOSTest. | van der Meer D et al. | β | 2020 | β |
| Convergent Evidence From Humans and Drosophila melanogaster Implicates the Transcription Factor MEF2B/Mef2 in Alcohol Sensitivity. | Schmitt RE et al. | β | 2019 | β |
| Genetic mapping and evolutionary analysisΒ of human-expanded cognitive networks. | Wei Y et al. | β | 2019 | β |
| Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits. | Zhao B et al. | β | 2019 | β |