Review of human butyrylcholinesterase structure, function, genetic variants, history of use in the clinic, and potential therapeutic uses.
paper
Cited
Public
Unavailable
- Authors
- Lockridge, Oksana
- Year
- 2015
- Journal
- Pharmacology & therapeutics
- PMID
- 25448037
- DOI
- 10.1016/j.pharmthera.2014.11.011
Phase I clinical trials have shown that pure human butyrylcholinesterase (BChE) is safe when administered to humans. A potential therapeutic use of BChE is for prevention of nerve agent toxicity. A recombinant mutant of BChE that rapidly inactivates cocaine is being developed as a treatment to help recovering cocaine addicts avoid relapse into drug taking. These clinical applications rely on knowledge of the structure, stability, and properties of BChE, information that is reviewed here. Gene therapy with a vector that sustains expression for a year from a single injection is a promising method for delivering therapeutic quantities of BChE.
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| Manganese attenuates the effects of arsenic on neurobehavioral and biochemical changes in mice co-exposed to arsenic and manganese. | Biswas S et al. | β | 2019 | β |
| Mass spectrometry based proteomic approach for the screening of butyrylcholinesterase adduct formation with organophosphates. | Dubrovskii Y et al. | β | 2019 | β |
| Multi-charged bis(p-calixarene)/pillararene functionalized gold nanoparticles for ultra-sensitive sensing of butyrylcholinesterase. | Li PY et al. | β | 2019 | β |
| Natural cholinesterase inhibitors from marine organisms. | Moodie LWK et al. | β | 2019 | β |
| Novel cholinesterase paralogs of Schistosoma mansoni have perceived roles in cholinergic signalling and drug detoxification and are essential for parasite survival. | Tedla BA et al. | β | 2019 | β |
| Susceptibility to adverse drug reactions. | Ferner R et al. | β | 2019 | β |
| Synergy between the alteration in the N-terminal region of butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease. | Jasiecki J et al. | β | 2019 | β |
| The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability. | Novichkova DA et al. | β | 2019 | β |
| Therapeutic Potential of Multifunctional Tacrine Analogues. | PrzybyΕowska M et al. | β | 2019 | β |
| Thiol-ene click reaction-induced fluorescence enhancement by altering the radiative rate for assaying butyrylcholinesterase activity. | Chen G et al. | β | 2019 | β |
| Time-course of human cholinesterases-catalyzed competing substrate kinetics. | Mukhametgalieva AR et al. | β | 2019 | β |
| A novel mutation in the BCHE gene and phenotype identified in a child with low butyrylcholinesterase activity: a case report. | Yu R et al. | β | 2018 | β |
| Association between early serum cholinesterase activity and 30-day mortality in sepsis-3 patients: A retrospective cohort study. | Peng ZL et al. | β | 2018 | β |
| Catalytic bioscavengers against organophosphorus agents: mechanistic issues of self-reactivating cholinesterases. | Lushchekina S et al. | β | 2018 | β |
| Catalytic bioscavengers as countermeasures against organophosphate nerve agents. | Goldsmith M et al. | β | 2018 | β |
| Changes in Cholinesterase Activity in Blood of Adolescent with Metabolic Syndrome after Supplementation with Extract from <i>Aronia melanocarpa</i>. | Duchnowicz P et al. | β | 2018 | β |
| Cholinesterases and Engineered Mutants for the Detection of Organophosphorus Pesticide Residues. | Xu YL et al. | β | 2018 | β |
| Cholinesterases and the fine line between poison and remedy. | Pope CN et al. | β | 2018 | β |
| Comparative in vitro and in vivo effects of chlorpyrifos oxon in the outbred CD-1 mouse (Mus musculus) and great plains toad (Anaxyrus cognatus). | Anderson T et al. | β | 2018 | β |
| Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly. | Leung MR et al. | β | 2018 | β |
| Design and synthesis of novel coumarin-pyridinium hybrids: In vitro cholinesterase inhibitory activity. | Vafadarnejad F et al. | β | 2018 | β |
| Development of Fc-Fused Cocaine Hydrolase for Cocaine Addiction Treatment: Catalytic and Pharmacokinetic Properties. | Chen X et al. | β | 2018 | β |
| Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease. | Li Q et al. | β | 2018 | β |
| Donepezil-melatonin hybrids as butyrylcholinesterase inhibitors: Improving binding affinity through varying mode of linking fragments. | ΕoziΕska I et al. | β | 2018 | β |
| Evaluation of butyrylcholinesterase inhibitory activity by chlorogenic acids and coffee extracts assed in ITC and docking simulation models. | Budryn G et al. | β | 2018 | β |
| Investigation of sarin(Se) reactivity against human plasma proteins using liquid chromatography-tandem mass spectrometry. | Saeidian H et al. | β | 2018 | β |
| Macrophage-targeted drugamers with enzyme-cleavable linkers deliver high intracellular drug dosing and sustained drug pharmacokinetics against alveolar pulmonary infections. | Su FY et al. | β | 2018 | β |
| Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques. | Uno Y et al. | β | 2018 | β |
| On-substrate Enzymatic Reaction to Determine Acetylcholinesterase Activity in Whole Blood by Paper Spray Mass Spectrometry. | Carmany DO et al. | β | 2018 | β |
| Optimization of Cholinesterase-Based Catalytic Bioscavengers Against Organophosphorus Agents. | Lushchekina SV et al. | β | 2018 | β |
| Proline-Rich Chaperones Are Compared Computationally and Experimentally for Their Abilities to Facilitate Recombinant Butyrylcholinesterase Tetramerization in CHO Cells. | Wang Q et al. | β | 2018 | β |
| Purification, characterization, and N-glycosylation of recombinant butyrylcholinesterase from transgenic rice cell suspension cultures. | Corbin JM et al. | β | 2018 | β |
| QM/MM Description of Newly Selected Catalytic Bioscavengers Against Organophosphorus Compounds Revealed Reactivation Stimulus Mediated by Histidine Residue in the Acyl-Binding Loop. | Zlobin A et al. | β | 2018 | β |
| Redox-Controlled Fluorescent Nanoswitch Based on Reversible Disulfide and Its Application in Butyrylcholinesterase Activity Assay. | Chen G et al. | β | 2018 | β |
| Role of Prenatal Hypoxia in Brain Development, Cognitive Functions, and Neurodegeneration. | Nalivaeva NN et al. | β | 2018 | β |
| Specific inhibition of acetylcholinesterase as an approach to decrease muscarinic side effects during myasthenia gravis treatment. | Petrov KA et al. | β | 2018 | β |
| Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis. | Karasova JZ et al. | β | 2017 | β |
| A high-throughput UHPLC-MS/MS method for the quantification of five aged butyrylcholinesterase biomarkers from human exposure to organophosphorus nerve agents. | Graham LA et al. | β | 2017 | β |
| An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. | Meyers JL et al. | β | 2017 | β |
| Anti-acetylcholinesterase activity and antioxidant properties of extracts and fractions of Carpolobia lutea. | Nwidu LL et al. | β | 2017 | β |
| Binding Space Concept: A New Approach To Enhance the Reliability of Docking Scores and Its Application to Predicting Butyrylcholinesterase Hydrolytic Activity. | Vistoli G et al. | β | 2017 | β |
| Brain region-specific effects of immobilization stress on cholinesterases in mice. | Valuskova P et al. | β | 2017 | β |
| Butyrylcholinesterase gene transfer in obese mice prevents postdieting body weight rebound by suppressing ghrelin signaling. | Chen VP et al. | β | 2017 | β |
| Butyrylcholinesterase regulates central ghrelin signaling and has an impact on food intake and glucose homeostasis. | Chen VP et al. | β | 2017 | β |
| [Cholinesterase activity assays and their use in the diagnosis of various pathological states including poisoning by neurotoxic agents]. | Pohanka M | β | 2017 | β |
| Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning. | Masson P et al. | β | 2017 | β |
| Development of immunosorbents coupled on-line to immobilized pepsin reactor and micro liquid chromatography-tandem mass spectrometry for analysis of butyrylcholinesterase in human plasma. | Bonichon M et al. | β | 2017 | β |
| Discovery of a butyrylcholinesterase-specific probe via a structure-based design strategy. | Yang SH et al. | β | 2017 | β |
| Effects of freeze-drying on antioxidant and anticholinesterase activities in various cultivars of kiwifruit (<i>Actinidia</i> spp.). | Hwang JS et al. | β | 2017 | β |
| New insights on molecular interactions of organophosphorus pesticides with esterases. | Mangas I et al. | β | 2017 | β |
| Plant-expressed cocaine hydrolase variants of butyrylcholinesterase exhibit altered allosteric effects of cholinesterase activity and increased inhibitor sensitivity. | Larrimore KE et al. | β | 2017 | β |
| Plasma butyrylcholinesterase activity: a possible biomarker for differential diagnosis between Alzheimer's disease and dementia with Lewy bodies? | Josviak ND et al. | β | 2017 | β |
| Polyionic complexes of butyrylcholinesterase and poly-l-lysine-g-poly(ethylene glycol): Comparative kinetics of catalysis and inhibition and inΒ vitro inactivation by proteases and heat. | Hester K et al. | β | 2017 | β |
| Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016). | Gorecki L et al. | β | 2017 | β |
| Protective propensity of bacoside A and bromelain on renal cholinesterases, Ξ³-Aminobutyric acid and serotonin level of Mus musculus intoxicated with dichlorvos. | Agarwal S et al. | β | 2017 | β |
| Quantification of Butyrylcholinesterase Activity as a Sensitive and Specific Biomarker of Alzheimer's Disease. | Macdonald IR et al. | β | 2017 | β |
| Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease. | Li Q et al. | β | 2017 | β |
| Resorcinol-, catechol- and saligenin-based bronchodilating Ξ²2-agonists as inhibitors of human cholinesterase activity. | Bosak A et al. | β | 2017 | β |
| Structural analysis of human glycoprotein butyrylcholinesterase using atomistic molecular dynamics: The importance of glycosylation site ASN241. | Bernardi A et al. | β | 2017 | β |
| Therapeutic Delivery of Butyrylcholinesterase by Brain-Wide Viral Gene Transfer to Mice. | Gao Y et al. | β | 2017 | β |
| Activity and polymorphisms of butyrylcholinesterase in a Polish population. | Jasiecki J et al. | β | 2016 | β |
| A Novel Way To Radiolabel Human Butyrylcholinesterase for Positron Emission Tomography through Irreversible Transfer of the Radiolabeled Moiety. | Sawatzky E et al. | β | 2016 | β |
| Chromosomal and Genetic Analysis of a Human Lung Adenocarcinoma Cell Line OM. | Li YW et al. | β | 2016 | β |
| Delayed recovery from paralysis associated with plasma cholinesterase deficiency. | Zhou W et al. | β | 2016 | β |
| Dynamics of human acetylcholinesterase bound to non-covalent and covalent inhibitors shedding light on changes to the water network structure. | Peters J et al. | β | 2016 | β |
| Emergence of catalytic bioscavengers against organophosphorus agents. | Masson P et al. | β | 2016 | β |
| Exome screening to identify loss-of-function mutations in the rhesus macaque for development of preclinical models of human disease. | Cornish AS et al. | β | 2016 | β |
| Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents. | Pisani L et al. | β | 2016 | β |
| Learning performances and vulnerability to amyloid toxicity in the butyrylcholinesterase knockout mouse. | Maurice T et al. | β | 2016 | β |
| Low Plasma Cholinesterase Activities are Associated with Deficits in Spatial Orientation, Reduced Ability to Perform Basic Activities of Daily Living, and Low Body Mass Index in Patients with Progressed Alzheimer's Disease. | Dingova D et al. | β | 2016 | β |
| Monoclonal antibodies to human butyrylcholinesterase reactive with butyrylcholinesterase in animal plasma. | Peng H et al. | β | 2016 | β |
| Naturally Occurring Genetic Variants of Human Acetylcholinesterase and Butyrylcholinesterase and Their Potential Impact on the Risk of Toxicity from Cholinesterase Inhibitors. | Lockridge O et al. | β | 2016 | β |
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| Reduced fibrillar Ξ²-amyloid in subcortical structures in a butyrylcholinesterase-knockout Alzheimer disease mouse model. | Darvesh S et al. | β | 2016 | β |
| SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides. | Gorecki L et al. | β | 2016 | β |
| Semicontinuous Bioreactor Production of Recombinant Butyrylcholinesterase in Transgenic Rice Cell Suspension Cultures. | Corbin JM et al. | β | 2016 | β |
| Slow-binding inhibition of cholinesterases, pharmacological and toxicological relevance. | Masson P et al. | β | 2016 | β |
| Stability of suxamethonium in pharmaceutical solution for injection by validated stability-indicating chromatographic method. | Beck W et al. | β | 2016 | β |
| Synthesis and study on activity in vitro of the high purity human butyrylcholinesterase conjugated with gold nanoparticles. | Sokolov OI et al. | β | 2016 | β |
| The Impact of Plasma Cholinergic Enzyme Activity andΒ Other Risk Factors for the Development ofΒ DeliriumΒ inΒ Patients Receiving Palliative Care. | Plaschke K et al. | β | 2016 | β |
| The potential role of bioscavenger in the medical management of nerve-agent poisoned casualties. | Rice H et al. | β | 2016 | β |
| Understanding the non-catalytic behavior of human butyrylcholinesterase silent variants: Comparison of wild-type enzyme, catalytically active Ala328Cys mutant, and silent Ala328Asp variant. | Lushchekina S et al. | β | 2016 | β |
| Assessing the therapeutic efficacy of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig. | Snider TH et al. | β | 2015 | β |
| Human butyrylcholinesterase polymorphism: Molecular modeling. | Lushchekina S et al. | β | 2015 | β |
| In vitro characterization of cationic copolymer-complexed recombinant human butyrylcholinesterase. | Pope C et al. | β | 2015 | β |
| New Insights into Butyrylcholinesterase Activity Assay: Serum Dilution Factor as a Crucial Parameter. | JoΕca J et al. | β | 2015 | β |