A link between adolescent nicotine metabolism and smoking topography.
- Authors
- Moolchan, Eric T; Parzynski, Craig S; Jaszyna-Gasior, Maria; Collins, Charles C; Leff, Michelle K; Zimmerman, Debra L
- Year
- 2009
- Journal
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- PMID
- 19423535
- DOI
- 10.1158/1055-9965.EPI-08-0592
- PMCID
- PMC2720594
Adult slow nicotine metabolizers have lower smoke exposure, carbon monoxide levels, and plasma nicotine levels than normal and fast metabolizers. Emerging evidence suggests nicotine metabolism influences smoking topography. This study investigated the association of nicotine metabolism (the ratio of plasma 3-hydroxycotinine to cotinine; 3OHCOT/COT) with smoking topography in adolescent smokers (n = 85; 65% female, 68% European American; mean age, 15.3 +/- 1.2 years; mean cigarettes per day, 18.5 +/- 8.5; mean Fagerström Test for Nicotine Dependence, 7.0 +/- 1.2) presenting for a nicotine replacement therapy trial. Measures obtained included puff volume, interpuff interval, number of puffs, puff duration, and puff velocity. Linear regression analysis controlling for hormonal contraception use showed that 3OHCOT/COT ratios predicted mean puff volume in the overall sample (t = 2.126; P = 0.037; adjusted R(2) = 0.067). After gender stratification, faster metabolism predicted higher mean puff volume (t = 2.81; P = 0.009; adjusted R(2) = 0.192) but fewer puffs (t = -3.160; P = 0.004; adjusted R(2) = 0.237) and lower mean puff duration (t = -2.06; P = 0.048; adjusted R(2) = 0.101) among boys only, suggesting that as nicotine metabolism increases, puff volume increases but puffing frequency decreases. No significant relationships were found between nicotine metabolism and total puff volume, mean puff duration, interpuff interval, or puff velocity. If confirmed in a broader sample of adolescent smokers, these findings suggest that as among dependent adult smokers, rate of metabolism among adolescent boys is linked to select parameters of puffing behavior that may affect cessation ability.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| CYP2A6 metabolism in the development of smoking behaviors in young adults. | 2018 | 28032407 |
| Nicotine metabolism and addiction among adolescent smokers. | 2013 | 22823143 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Predictors of Nicotine Dependence Among Adult Male Midwakh and Cigarette Smokers. | Al Sharbatti S et al. | — | 2022 | → |
| Polytobacco use among a nationally-representative sample of black high school students. | Gilreath TD et al. | — | 2021 | → |
| CYP2A6 metabolism in the development of smoking behaviors in young adults. | Olfson E et al. | — | 2018 | → |
| Nicotine metabolite ratio predicts smoking topography: The Pennsylvania Adult Smoking Study. | Chen A et al. | — | 2018 | → |
| Relationship between cotinine and trans-3'-hydroxycotinine glucuronidation and the nicotine metabolite ratio in Caucasian smokers. | Jacobson GA et al. | — | 2014 | → |
| Smoking behaviour and compensation: a review of the literature with meta-analysis. | Scherer G et al. | — | 2014 | → |
| Age-related differences in the disposition of nicotine and metabolites in rat brain and plasma. | Vieira-Brock PL et al. | — | 2013 | → |
| Nicotine metabolism and addiction among adolescent smokers. | Rubinstein ML et al. | — | 2013 | → |
| Nicotine intake and smoking topography in smokers with bipolar disorder. | Williams JM et al. | — | 2012 | → |
| Reproducibility of the nicotine metabolite ratio in cigarette smokers. | St Helen G et al. | — | 2012 | → |
| Tobacco use and suicidality: latent patterns of co-occurrence among black adolescents. | Gilreath TD et al. | — | 2012 | → |
| Shorter interpuff interval is associated with higher nicotine intake in smokers with schizophrenia. | Williams JM et al. | — | 2011 | → |
| Systematic review of the relationship between the 3-hydroxycotinine/cotinine ratio and cigarette dependence. | West O et al. | — | 2011 | → |