Effect of chronic alcohol consumption on the activity of the hypothalamic-pituitary-adrenal axis and pituitary beta-endorphin as a function of alcohol intake, age, and gender.
paper
Cited
Public
Unavailable
- Authors
- Gianoulakis, Christina; Dai, Xing; Brown, Thomas
- Year
- 2003
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 12658106
- DOI
- 10.1097/01.ALC.0000056614.96137.B8
BACKGROUND: Experimental evidence indicates that components of the hypothalamic-pituitary-adrenal (HPA) axis and of the endogenous opioid system, such as beta-endorphin (beta-END), influence alcohol consumption, whereas chronic alcohol abuse alters the activity of both systems. Furthermore, gender and age differences have been reported in the activity of the HPA axis under basal conditions, in response to stress and acute alcohol challenge. The objective of the present studies was to investigate the hypothesis that chronic alcohol consumption alters the activity of the HPA axis and pituitary beta-END as a function of severity of alcohol abuse, gender, and age. METHODS: Three age groups of each gender (18-29, 30-44, and 45-60 years old) were recruited. Each age and gender group included four subgroups: (a) nondrinkers, (b) light drinkers, (c) heavy drinkers, and (d) alcoholics in treatment. Demographic characteristics, alcohol consumption, and presence of alcohol dependence were recorded by using a structured interview. Blood samples were taken on the day of the interview. The levels of plasma adrenal corticotropic hormone (ACTH), cortisol, and beta-END were estimated as an index of the activity of the HPA-axis and pituitary beta-END. RESULTS: Plasma ACTH and beta-END levels were significantly lower in females than males of all age and drinking category groups. Plasma cortisol levels were higher in 18- to 29-year-old female subjects compared with the 18- to 29-year-old male subjects. The plasma ACTH and beta-END levels were lower whereas plasma cortisol levels were higher in heavy drinkers than nondrinkers. This decrease in plasma ACTH and beta-END levels with heavy drinking was more pronounced in female than male subjects of the 30-44 and 45-60 age groups. CONCLUSIONS: Chronic drinking, gender, and age influence the activity of the HPA-axis and pituitary beta-END, which in turn may influence drinking behavior.
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| Title | Year | PMID |
|---|---|---|
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | 2013 | 23981442 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Mast-cell-specific receptor mediates alcohol-withdrawal-associated headache in male mice. | Son H et al. | β | 2024 | β |
| Ξ²-Endorphin influences sedative and ataxic effects of alcohol. | Stea SG et al. | β | 2024 | β |
| Alcohol-induced Cushing syndrome: report of eight cases and review of the literature. | Surani A et al. | β | 2023 | β |
| Recognition of Nonneoplastic Hypercortisolism in the Evaluation of Patients With Cushing Syndrome. | Findling JW et al. | β | 2023 | β |
| Cue-induced cocaine craving enhances psychosocial stress and vice versa in chronic cocaine users. | Kexel AK et al. | β | 2022 | β |
| Exploring the Therapeutic Potential of Targeting Purinergic and Orexinergic Receptors in Alcoholic Neuropathy. | Madaan P et al. | β | 2022 | β |
| Paternal Nicotine/Ethanol/Caffeine Mixed Exposure Induces Offspring Rat Dysplasia and Its Potential "GC-IGF1" Programming Mechanism. | Liu Y et al. | β | 2022 | β |
| Acupuncture Alleviates Anxiety and 22-kHz Ultrasonic Vocalizations in Rats Subjected to Repeated Alcohol Administration by Modulating the Brain-Derived Neurotrophic Factor/Corticotropin-Releasing Hormone Signaling Pathway. | Seo SY et al. | β | 2021 | β |
| Differential stress response to psychological and physical stressors in children using spatial versus response-dependent navigation strategies. | West GL et al. | β | 2021 | β |
| From phone use to speeding and driving under influence: Identifying clusters of driving risk behaviors as an opportunity for targeted interventions. | Rabelo-da-Ponte FD et al. | β | 2021 | β |
| Mast cell-specific receptor/corticotropin-releasing factor axis regulates alcohol withdrawal-associated headache | Son H et al. | β | 2021 | β |
| Neuroendocrine and autonomic stress systems activity in young adults raised by mothers with mental health and substance abuse problems: A prospective cohort study. | Burenkova OV et al. | β | 2021 | β |
| Suicide Risk and Addiction: The Impact of Alcohol and Opioid Use Disorders. | Rizk MM et al. | β | 2021 | β |
| The effects of peri-adolescent alcohol use on the developing hippocampus. | Walker CD et al. | β | 2021 | β |
| Alterations in circadian rhythms following alcohol use: A systematic review. | Meyrel M et al. | β | 2020 | β |
| Biological intersection of sex, age, and environment in the corticotropin releasing factor (CRF) system and alcohol. | Agoglia AE et al. | β | 2020 | β |
| Measuring Earwax Cortisol Concentration using a non-stressful sampling method. | Herane-Vives A et al. | β | 2020 | β |
| Oxytocin treatment for alcoholism: Potential neurocircuitry targets. | Peris J et al. | β | 2020 | β |
| Roles of Ξ²-Endorphin in Stress, Behavior, Neuroinflammation, and Brain Energy Metabolism. | Pilozzi A et al. | β | 2020 | β |
| Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). | Sumi M et al. | β | 2019 | β |
| Craving, cortisol and behavioral alcohol motivation responses to stress and alcohol cue contexts and discrete cues in binge and non-binge drinkers. | Blaine SK et al. | β | 2019 | β |
| Exercise-driven restoration of the alcohol-damaged brain. | West RK et al. | β | 2019 | β |
| The role of substance use, smoking, and inflammation in risk for suicidal behavior. | Chang HB et al. | β | 2019 | β |
| A Review of the Physiological Effects and Mechanisms of Singing. | Kang J et al. | β | 2018 | β |
| Biological stress indicators as risk markers for increased alcohol use following traumatic experiences. | Trautmann S et al. | β | 2018 | β |
| Blunted cortisol reactivity and risky driving in young offenders - a pilot study. | Couture S et al. | β | 2018 | β |
| Reflexology: A randomised controlled trial investigating the effects on beta-endorphin, cortisol and pregnancy related stress. | McCullough JEM et al. | β | 2018 | β |
| Substance-related disorders: A review of prevalence and correlates among patients with chronic pain. | Martel MO et al. | β | 2018 | β |
| Alterations in serum paraoxonase-1 activity and lipid profile in chronic alcoholic patients infected with Strongyloides stercoralis. | de Jesus InΓͺs E et al. | β | 2017 | β |
| Defective axonal transport: A common pathological mechanism in inherited and acquired peripheral neuropathies. | Prior R et al. | β | 2017 | β |
| Exercise training reduces alcohol consumption but does not affect HPA-axis activity in heavy drinkers. | Georgakouli K et al. | β | 2017 | β |
| The HPA axis and ethanol: a synthesis of mathematical modelling and experimental observations. | ΔupiΔ Ε½ et al. | β | 2017 | β |
| Annual Research Review: On the developmental neuropsychology of substance use disorders. | Conrod PJ et al. | β | 2016 | β |
| A Review on the Sex Differences in Organ and System Pathology with Alcohol Drinking. | Vatsalya V et al. | β | 2016 | β |
| Association between Strongyloides stercoralis infection and cortisol secretion in alcoholic patients. | Silva ML et al. | β | 2016 | β |
| Cytokine production capacity in depression and anxiety. | Vogelzangs N et al. | β | 2016 | β |
| Genome-wide gene-based analysis suggests an association between Neuroligin 1 (NLGN1) and post-traumatic stress disorder. | Kilaru V et al. | β | 2016 | β |
| Personality, Executive Control, and Neurobiological Characteristics Associated with Different Forms of Risky Driving. | Brown TG et al. | β | 2016 | β |
| Ξ²-endorphin regulates alcohol consumption induced by exercise restriction in female mice. | McGonigle CE et al. | β | 2016 | β |
| Anxiety Symptoms During Adolescence Predicts Salivary Cortisol in Early Adulthood Among Blacks; Sex differences. | Assari S et al. | β | 2015 | β |
| Chronic intermittent voluntary alcohol drinking induces hyperalgesia in Sprague-Dawley rats. | Fu R et al. | β | 2015 | β |
| Congenital adrenal hyperplasia and risk for psychiatric disorders in girls and women born between 1915 and 2010: A total population study. | Engberg H et al. | β | 2015 | β |
| Increased alcohol consumption in urocortin 3 knockout mice is unaffected by chronic inflammatory pain. | Smith ML et al. | β | 2015 | β |
| Longitudinal associations between diurnal cortisol slope and alcohol use across adolescence: a seven-year prospective study. | Ruttle PL et al. | β | 2015 | β |
| Lower Cortisol Activity is Associated with First-Time Driving while Impaired. | Couture S et al. | β | 2015 | β |
| Predictors of hair cortisol concentrations in older adults. | Feller S et al. | β | 2014 | β |
| Role of hypothalamic corticotropin-releasing factor in mediating alcohol-induced activation of the rat hypothalamic-pituitary-adrenal axis. | Rivier C | β | 2014 | β |
| Cortisol levels in children of parents with a substance use disorder. | Evans BE et al. | β | 2013 | β |
| Independent contributions of alcohol and stress axis hormones to painful peripheral neuropathy. | Ferrari LF et al. | β | 2013 | β |
| Lipids and addiction: how sex steroids, prostaglandins, and cannabinoids interact with drugs of abuse. | Leishman E et al. | β | 2013 | β |
| Males and females are just different: sexually dimorphic responses to chronic ethanol exposure in hippocampal slice cultures. | Wiren KM | β | 2013 | β |
| Physiological and endocrine reactions to psychosocial stress in alcohol use disorders: duration of abstinence matters. | Starcke K et al. | β | 2013 | β |
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | McClintick JN et al. | β | 2013 | β |
| Alcohol dependence as a chronic pain disorder. | Egli M et al. | β | 2012 | β |
| Alcoholic neuropathy: possible mechanisms and future treatment possibilities. | Chopra K et al. | β | 2012 | β |
| Association of depressive disorders, depression characteristics and antidepressant medication with inflammation. | Vogelzangs N et al. | β | 2012 | β |
| Corticotrophin releasing factor (CRF) induced reinstatement of cocaine seeking in male and female rats. | Buffalari DM et al. | β | 2012 | β |
| Decision making under stress: a selective review. | Starcke K et al. | β | 2012 | β |
| Identification of POMC exonic variants associated with substance dependence and body mass index. | Wang F et al. | β | 2012 | β |
| Sex hormone activity in alcohol addiction: integrating organizational and activational effects. | Lenz B et al. | β | 2012 | β |
| BDNF Val66Met polymorphism is associated with higher anticipatory cortisol stress response, anxiety, and alcohol consumption in healthy adults. | Colzato LS et al. | β | 2011 | β |
| Heavy alcohol use, rather than alcohol dependence, is associated with dysregulation of the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. | Boschloo L et al. | β | 2011 | β |
| Adrenocortical and pituitary glucocorticoid feedback in abstinent alcohol-dependent women. | Adinoff B et al. | β | 2010 | β |
| Alcohol-use disorders in the critically ill patient. | de Wit M et al. | β | 2010 | β |
| Community-dwelling cocaine-dependent men and women respond differently to social stressors versus cocaine cues. | Waldrop AE et al. | β | 2010 | β |
| Opioid-like activity of naltrexone on natural killer cell cytolytic activity and cytokine production in splenocytes: effects of alcohol. | Boyadjieva NI et al. | β | 2010 | β |
| Reactivity to laboratory stress provocation predicts relapse to cocaine. | Back SE et al. | β | 2010 | β |
| Relationship between alcohol use disorders, cortisol concentrations, and cytokine levels in patients with sepsis. | de Wit M et al. | β | 2010 | β |
| Assessing the neuroendocrine stress response in the functional neuroimaging context. | King AP et al. | β | 2009 | β |
| Factors contributing to the facial aging of identical twins. | Guyuron B et al. | β | 2009 | β |
| From the brain to bad behaviour and back again: neurocognitive and psychobiological mechanisms of driving while impaired by alcohol. | Brown TG et al. | β | 2009 | β |
| Response to corticotropin-releasing hormone infusion in cocaine-dependent individuals. | Brady KT et al. | β | 2009 | β |
| Sexually dimorphic response of the hypothalamo-pituitary-adrenal axis to chronic alcohol consumption and withdrawal. | Silva SM et al. | β | 2009 | β |
| Why do we respond so differently? Reviewing determinants of human salivary cortisol responses to challenge. | Kudielka BM et al. | β | 2009 | β |
| Alcohol-induced stress in painful alcoholic neuropathy. | Dina OA et al. | β | 2008 | β |
| Effects of gender and cigarette smoking on reactivity to psychological and pharmacological stress provocation. | Back SE et al. | β | 2008 | β |
| Exploring the link between gender, sensation seeking, and family history of alcoholism in cortisol stress-response dampening. | Croissant B et al. | β | 2008 | β |
| Hypothalamic-pituitary-adrenal axis response to stress in male DUI recidivists. | Couture S et al. | β | 2008 | β |
| Influence of beta-Endorphin on anxious behavior in mice: interaction with EtOH. | Grisel JE et al. | β | 2008 | β |
| The potential role of a corticotropin-releasing factor receptor-1 antagonist in psychiatric disorders. | Stahl SM et al. | β | 2008 | β |
| The relationship between alcohol consumption and cortisol secretion in an aging cohort. | Badrick E et al. | β | 2008 | β |
| A history of aggression is a risk factor for postoperative confusion in elderly male drinkers. | Kudoh A et al. | β | 2007 | β |
| Cold pressor task reactivity: predictors of alcohol use among alcohol-dependent individuals with and without comorbid posttraumatic stress disorder. | Brady KT et al. | β | 2006 | β |
| Hippocampus volume loss due to chronic heavy drinking. | Beresford TP et al. | β | 2006 | β |
| PTSD and the HPA axis: differences in response to the cold pressor task among individuals with child vs. adult trauma. | Santa Ana EJ et al. | β | 2006 | β |
| Role of beta-endorphin, corticotropin-releasing hormone, and autonomic nervous system in mediation of the effect of chronic ethanol on natural killer cell cytolytic activity. | Boyadjieva N et al. | β | 2006 | β |
| Levels and circadian rhythmicity of plasma ACTH, cortisol, and beta-endorphin as a function of family history of alcoholism. | Gianoulakis C et al. | β | 2005 | β |
| Naltrexone augments the effects of nicotine replacement therapy in female smokers. | Byars JA et al. | β | 2005 | β |
| Salivary cortisol: a predictor of convictions for driving under the influence of alcohol? | Brown TG et al. | β | 2005 | β |
| Alcoholism and neuro-immune-endocrine interactions: physiochemical aspects. | Haddad JJ | β | 2004 | β |
| Endogenous opiates and behavior: 2003. | Bodnar RJ et al. | β | 2004 | β |
| Increased cortisol response to surgery in patients with alcohol problems who developed postoperative confusion. | Kudoh A et al. | β | 2004 | β |
| United States male students who heavily consume alcohol in Mexico are at greater risk of travelers' diarrhea than their female counterparts. | Huang DB et al. | β | 2004 | β |