A mutation creating a potential illegitimate microRNA target site in the myostatin gene affects muscularity in sheep.
- Authors
- Clop, Alex; Marcq, Fabienne; Takeda, Haruko; Pirottin, Dimitri; Tordoir, Xavier; BibΓ©, Bernard; Bouix, Jacques; Caiment, Florian; Elsen, Jean-Michel; Eychenne, Francis; Larzul, Catherine; Laville, Elisabeth; Meish, FranΓ§oise; Milenkovic, Dragan; Tobin, James; Charlier, Carole; Georges, Michel
- Year
- 2006
- Journal
- Nature genetics
- PMID
- 16751773
- DOI
- 10.1038/ng1810
Texel sheep are renowned for their exceptional meatiness. To identify the genes underlying this economically important feature, we performed a whole-genome scan in a Romanov x Texel F2 population. We mapped a quantitative trait locus with a major effect on muscle mass to chromosome 2 and subsequently fine-mapped it to a chromosome interval encompassing the myostatin (GDF8) gene. We herein demonstrate that the GDF8 allele of Texel sheep is characterized by a G to A transition in the 3' UTR that creates a target site for mir1 and mir206, microRNAs (miRNAs) that are highly expressed in skeletal muscle. This causes translational inhibition of the myostatin gene and hence contributes to the muscular hypertrophy of Texel sheep. Analysis of SNP databases for humans and mice demonstrates that mutations creating or destroying putative miRNA target sites are abundant and might be important effectors of phenotypic variation.
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| Centronuclear myopathies under attack: A plethora of therapeutic targets. | Tasfaout H et al. | β | 2018 | β |
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| Copy number variation in the MSRB3 gene enlarges porcine ear size through a mechanism involving miR-584-5p. | Chen C et al. | β | 2018 | β |
| CRISPR/Cas9-mediated MSTN disruption and heritable mutagenesis in goats causes increased body mass. | Wang X et al. | β | 2018 | β |
| Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish. | Wang C et al. | β | 2018 | β |
| Detection of myostatin gene MSTN in some goat breeds (<i>Capra hircus</i>). | Dowidar YA et al. | β | 2018 | β |
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| Evolutionary epidemiology of schistosomiasis: linking parasite genetics with disease phenotype in humans. | Huyse T et al. | β | 2018 | β |
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| Genome Editing of Pigs for Agriculture and Biomedicine. | Yang H et al. | β | 2018 | β |
| Genome wide analyses uncover allele-specific RNA editing in human and mouse. | Zhou ZY et al. | β | 2018 | β |
| Hydrogen Sulfide Donor NaHS Improves Metabolism and Reduces Muscle Atrophy in Type 2 Diabetes: Implication for Understanding Sarcopenic Pathophysiology. | Bitar MS et al. | β | 2018 | β |
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| Incorporation of a skeletal muscle-specific enhancer in the regulatory region of Igf1 upregulates IGF1 expression and induces skeletal muscle hypertrophy. | Zou Y et al. | β | 2018 | β |
| Influence of physical exercise on microRNAs in skeletal muscle regeneration, aging and diseases. | Ultimo S et al. | β | 2018 | β |
| Inhibin Ξ²E (INHBE) is a possible insulin resistance-associated hepatokine identified by comprehensive gene expression analysis in human liver biopsy samples. | Sugiyama M et al. | β | 2018 | β |
| Livestock 2.0 - genome editing for fitter, healthier, and more productive farmed animals. | Tait-Burkard C et al. | β | 2018 | β |
| MicroRNA duplication accelerates the recruitment of new targets during vertebrate evolution. | Luo J et al. | β | 2018 | β |
| MiR-27b promotes sheep skeletal muscle satellite cell proliferation by targeting <i>myostatin gene</i>. | Zhang W et al. | β | 2018 | β |
| Myostatin is expressed in bovine ovarian follicles and modulates granulosal and thecal steroidogenesis | Cheewasopit W et al. | β | 2018 | β |
| Parallel comparative proteomics and phosphoproteomics reveal that cattle <i>myostatin</i> regulates phosphorylation of key enzymes in glycogen metabolism and glycolysis pathway. | Yang S et al. | β | 2018 | β |
| Past, Present, and Future Perspective of Targeting Myostatin and Related Signaling Pathways to Counteract Muscle Atrophy. | Hoogaars WMH et al. | β | 2018 | β |
| Peptidyl-prolyl cis-trans isomerase NIMA interacting 1 regulates skeletal muscle fusion through structural modification of Smad3 in the linker region. | Islam R et al. | β | 2018 | β |
| Short-hairpin Mediated Myostatin Knockdown Resulted in Altered Expression of Myogenic Regulatory Factors with Enhanced Myoblast Proliferation in Fetal Myoblast Cells of Goats. | Kumar R et al. | β | 2018 | β |
| The myostatin gene: an overview of mechanisms of action and its relevance to livestock animals. | Aiello D et al. | β | 2018 | β |
| The "speed gene" effect of myostatin arises in Thoroughbred horses due to a promoter proximal SINE insertion. | Rooney MF et al. | β | 2018 | β |
| Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation. | Le VQ et al. | β | 2018 | β |
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| Ammonia elicits a different myogenic response in avian and murine myotubes. | Stern RA et al. | β | 2017 | β |
| Chicken muscle mitochondrial content appears co-ordinately regulated and is associated with performance phenotypes. | Reverter A et al. | β | 2017 | β |
| CRISPR/Cas9-mediated knockout of myostatin in Chinese indigenous Erhualian pigs. | Wang K et al. | β | 2017 | β |
| Decreased myoblast differentiation in chronic binge alcohol-administered simian immunodeficiency virus-infected male macaques: role of decreased miR-206. | Simon L et al. | β | 2017 | β |
| Discovery of Cancer Driver Long Noncoding RNAs across 1112 Tumour Genomes: New Candidates and Distinguishing Features. | LanzΓ³s A et al. | β | 2017 | β |
| Enhancing Targeted Genomic DNA Editing in Chicken Cells Using the CRISPR/Cas9 System. | Wang L et al. | β | 2017 | β |
| Epigenetics of cancer-associated muscle catabolism. | Carr RM et al. | β | 2017 | β |
| Equine performance genes and the future of doping in horseracing. | Wilkin T et al. | β | 2017 | β |
| Evolution of flower color pattern through selection on regulatory small RNAs. | Bradley D et al. | β | 2017 | β |
| Expression Profiling of Activin type IIB Receptor During Ontogeny in Broiler and Indigenous Chicken. | Guru Vishnu PB et al. | β | 2017 | β |
| Fifteen years of quantitative trait loci studies in fish: challenges and future directions. | Ashton DT et al. | β | 2017 | β |
| Generation of Myostatin Gene-Edited Channel Catfish (Ictalurus punctatus) via Zygote Injection of CRISPR/Cas9 System. | Khalil K et al. | β | 2017 | β |
| Genome-Wide Analysis Reveals Extensive Changes in LncRNAs during Skeletal Muscle Development in Hu Sheep. | Ren C et al. | β | 2017 | β |
| Genome-Wide microRNA Binding Site Variation between Extinct Wild Aurochs and Modern Cattle Identifies Candidate microRNA-Regulated Domestication Genes. | Braud M et al. | β | 2017 | β |
| High-resolution melting analysis for detection of a single-nucleotide polymorphism and the genotype of the myostatin gene in warmblood horses. | Serpa PB et al. | β | 2017 | β |
| High-throughput sequencing of pituitary and hypothalamic microRNA transcriptome associated with high rate of egg production. | Wu N et al. | β | 2017 | β |
| Identification of genome-wide non-canonical spliced regions and analysis of biological functions for spliced sequences using Read-Split-Fly. | Bai Y et al. | β | 2017 | β |
| Loss-of-function myostatin mutation increases insulin sensitivity and browning of white fat in Meishan pigs. | Cai C et al. | β | 2017 | β |
| MicroRNA-based transcriptomic responses of Atlantic salmon during infection by the intracellular bacterium Piscirickettsia salmonis. | Valenzuela-Miranda D et al. | β | 2017 | β |
| MicroRNAs as biomarkers for psychiatric disorders with a focus on autism spectrum disorder: Current progress in genetic association studies, expression profiling, and translational research. | Hu Y et al. | β | 2017 | β |
| MicroRNAs as Important Regulators of Exercise Adaptation. | Silva GJJ et al. | β | 2017 | β |
| miR-195 Regulates Proliferation and Apoptosis through Inhibiting the mTOR/p70s6k Signaling Pathway by Targeting HMGA2 in Esophageal Carcinoma Cells. | Li Y et al. | β | 2017 | β |
| miR-361-3p regulates FSH by targeting FSHB in a porcine anterior pituitary cell model. | Ye RS et al. | β | 2017 | β |
| Muscle-specific microRNA-206 targets multiple components in dystrophic skeletal muscle representing beneficial adaptations. | Amirouche A et al. | β | 2017 | β |
| Myostatin deficiency is associated with lipidomic abnormalities in skeletal muscles. | Baati N et al. | β | 2017 | β |
| Myostatin propeptide mutation of the hypermuscular <i>Compact</i> mice decreases the formation of myostatin and improves insulin sensitivity. | Kocsis T et al. | β | 2017 | β |
| Pharmacological inhibition of myostatin improves skeletal muscle mass and function in a mouse model of stroke. | Desgeorges MM et al. | β | 2017 | β |
| Pou1f1, the key transcription factor related to somatic growth in tilapia (Orechromis niloticus), is regulated by two independent post-transcriptional regulation mechanisms. | Wang D et al. | β | 2017 | β |
| RNA-Seq reveals MicroRNA expression signature and genetic polymorphism associated with growth and muscle quality traits in rainbow trout. | Paneru BD et al. | β | 2017 | β |
| RNA sequencing reveals candidate genes and polymorphisms related to sperm DNA integrity in testis tissue from boars. | van Son M et al. | β | 2017 | β |
| The distribution of runs of homozygosity and selection signatures in six commercial meat sheep breeds. | Purfield DC et al. | β | 2017 | β |
| The Importance of Endophenotypes to Evaluate the Relationship between Genotype and External Phenotype. | Te Pas MF et al. | β | 2017 | β |
| Transcriptome analysis of comb and testis from Rose-comb Silky chicken (R1/R1) and Beijing Fatty wild type chicken (r/r). | Wang Y et al. | β | 2017 | β |
| Variants in the 3' untranslated region of the ovine acetyl-coenzyme A acyltransferase 2 gene are associated with dairy traits and exhibit differential allelic expression. | Miltiadou D et al. | β | 2017 | β |
| A 90-Day Feeding Study in Rats to Assess the Safety of Genetically Engineered Pork. | Xiao GJ et al. | β | 2016 | β |
| Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice. | Camporez JP et al. | β | 2016 | β |
| Apolipoprotein E Epsilon 4 Enhances the Association between the rs2910164 Polymorphism of miR-146a and Risk of Atherosclerotic Cerebral Infarction. | Zhong H et al. | β | 2016 | β |
| A short insertion mutation disrupts genesis of miR-16 and causes increased body weight in domesticated chicken. | Jia X et al. | β | 2016 | β |
| Association genetics in Populus reveals the interactions between Pto-miR160a and its target Pto-ARF16. | Tian J et al. | β | 2016 | β |
| Association of polymorphisms at the microRNA binding site of the caprine KITLG 3'-UTR with litter size. | An X et al. | β | 2016 | β |
| Characterization of an extensive rainbow trout miRNA transcriptome by next generation sequencing. | Juanchich A et al. | β | 2016 | β |
| Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation. | Hoffmann S et al. | β | 2016 | β |
| Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures. | Kornegay JN et al. | β | 2016 | β |
| Efficient Generation of Myostatin Gene Mutated Rabbit by CRISPR/Cas9. | Lv Q et al. | β | 2016 | β |
| Epigenetics and developmental programming of welfare and production traits in farm animals. | Sinclair KD et al. | β | 2016 | β |
| Expression of microRNA-30a-5p in drug-resistant and drug-sensitive ovarian cancer cell lines. | Liu J et al. | β | 2016 | β |
| Expression profiling and functional characterization of miR-192 throughout sheep skeletal muscle development. | Zhao Q et al. | β | 2016 | β |
| Generation and evaluation of Myostatin knock-out rabbits and goats using CRISPR/Cas9 system. | Guo R et al. | β | 2016 | β |
| Generation of biallelic knock-out sheep via gene-editing and somatic cell nuclear transfer. | Li H et al. | β | 2016 | β |
| Global investigation of the co-evolution of MIRNA genes and microRNA targets during soybean domestication. | Liu T et al. | β | 2016 | β |
| Identification and Expression Profiling of miRNAome in Goat longissimus dorsi Muscle from Prenatal Stages to a Neonatal Stage. | Guo J et al. | β | 2016 | β |
| Identification of a functional SNP in the 3'-UTR of caprine MTHFR gene that is associated with milk protein levels. | An X et al. | β | 2016 | β |
| Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues. | Dong J et al. | β | 2016 | β |
| Inhibition of the myostatin/Smad signaling pathway by short decorin-derived peptides. | El Shafey N et al. | β | 2016 | β |
| INVITED REVIEW: Inhibitors of myostatin as methods of enhancing muscle growth and development. | Chen PR et al. | β | 2016 | β |
| Knockout of Myostatin by Zinc-finger Nuclease in Sheep Fibroblasts and Embryos. | Zhang X et al. | β | 2016 | β |
| miR-762 promotes porcine immature Sertoli cell growth via the ring finger protein 4 (RNF4) gene. | Ma C et al. | β | 2016 | β |
| Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriers. | Benitez-Buelga C et al. | β | 2016 | β |
| Multiplex gene editing via CRISPR/Cas9 exhibits desirable muscle hypertrophy without detectable off-target effects in sheep. | Wang X et al. | β | 2016 | β |
| Mutation screening of MIR146A/B and BRCA1/2 3'-UTRs in the GENESIS study. | Garcia AI et al. | β | 2016 | β |
| Novel mutations in the TP63 gene are potentially associated with MΓΌllerian duct anomalies. | Wang X et al. | β | 2016 | β |
| Oocyte-somatic cell interactions in the human ovary-novel role of bone morphogenetic proteins and growth differentiation factors. | Chang HM et al. | β | 2016 | β |
| Paracrine and endocrine modes of myostatin action. | Lee YS et al. | β | 2016 | β |
| Pre-miRNA variants as predictors of clinical outcome in patients with squamous cell carcinomas of the nonoropharynx. | Wang C et al. | β | 2016 | β |
| RNA-seq analysis reveals new candidate genes for drip loss in a PietrainΒ ΓΒ DurocΒ ΓΒ LandraceΒ ΓΒ Yorkshire population. | Li B et al. | β | 2016 | β |
| Significance of microRNA-related variants in susceptibility to recurrence of oropharyngeal cancer patients after definitive radiotherapy. | Chen X et al. | β | 2016 | β |
| Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy. | Tando T et al. | β | 2016 | β |
| Structural and Dynamic Characterization of the C313Y Mutation in Myostatin Dimeric Protein, Responsible for the "Double Muscle" Phenotype in Piedmontese Cattle. | Bongiorni S et al. | β | 2016 | β |
| Study of bovine gene: the temporal-spatial expression patterns, polymorphism and association analysis with meat production traits. | Juszczuk-Kubiak E et al. | β | 2016 | β |
| Targeted Editing of Myostatin Gene in Sheep by Transcription Activator-like Effector Nucleases. | Zhao X et al. | β | 2016 | β |
| The role of microRNA-1 and microRNA-206 in the proliferation and differentiation of bovine skeletal muscle satellite cells. | Dai Y et al. | β | 2016 | β |
| Two single nucleotide polymorphisms in the promoter of the ovine myostatin gene (MSTN) and their effect on growth and carcass muscle traits in New Zealand Romney sheep. | Wang J et al. | β | 2016 | β |
| Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels. | Staley LA et al. | β | 2016 | β |
| Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels. | Ebbert MT et al. | β | 2016 | β |
| WFIKKN1 and WFIKKN2: "Companion" proteins regulating TGFB activity. | Monestier O et al. | β | 2016 | β |
| A comprehensive linkage map and QTL map for carcass traits in a cross between Giant Grey and New Zealand White rabbits. | Sternstein I et al. | β | 2015 | β |
| Adaptive potential of genomic structural variation in human and mammalian evolution. | Radke DW et al. | β | 2015 | β |
| Altered Gene Expression Associated with microRNA Binding Site Polymorphisms. | VΓ΅sa U et al. | β | 2015 | β |
| An insertion/deletion polymorphism at the microRNA-122 binding site in the interleukin-1Ξ± 3'-untranslated region is associated with a risk for osteoarthritis. | Yang F et al. | β | 2015 | β |
| A novel mechanism of myostatin regulation by its alternative splicing variant during myogenesis in avian species. | Shin S et al. | β | 2015 | β |
| A phase 1/2a follistatin gene therapy trial for becker muscular dystrophy. | Mendell JR et al. | β | 2015 | β |
| Association genetics in Populus reveals the interactions between Pt-miR397a and its target genes. | Chen J et al. | β | 2015 | β |
| Association of CYP450 single nucleotide polymorphisms with the efficacy of epidural ropivacaine during mastectomy. | Liu J et al. | β | 2015 | β |
| A toolbox for miRNA analysis. | Svoboda P | β | 2015 | β |
| BMPs and the muscle-bone connection. | Sartori R et al. | β | 2015 | β |
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| Candidate genes underlying heritable differences in reproductive seasonality between wild and domestic rabbits. | Carneiro M et al. | β | 2015 | β |
| Characterization of miRNAs from hydrothermal vent shrimp Rimicaris exoculata. | Zhou Y et al. | β | 2015 | β |
| Combined QTL and selective sweep mappings with coding SNP annotation and cis-eQTL analysis revealed PARK2 and JAG2 as new candidate genes for adiposity regulation. | Roux PF et al. | β | 2015 | β |
| Connecting Myokines and Metabolism. | Ahima RS et al. | β | 2015 | β |
| Coordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project. | Andersson L et al. | β | 2015 | β |
| Dystrophin induced cognitive impairment: mechanisms, models and therapeutic strategies. | Anand A et al. | β | 2015 | β |
| Effect of variation in ovine WFIKKN2 on growth traits appears to be gender-dependent. | Wang J et al. | β | 2015 | β |
| Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes. | Crispo M et al. | β | 2015 | β |
| Elevated insulin-like growth factor 2 expression may contribute to the hypermuscular phenotype of myostatin null mice. | Clark DL et al. | β | 2015 | β |
| Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy. | Sepulveda PV et al. | β | 2015 | β |
| Expression of myostatin in the spotted rose snapper Lutjanus guttatus during larval and juvenile development under cultured conditions. | Torres-Velarde J et al. | β | 2015 | β |
| Expression of the myostatin gene in the adductor muscle of the Pacific lion-paw scallop Nodipecten subnodosus in association with growth and environmental conditions. | Morelos RM et al. | β | 2015 | β |
| Expression of the SIRT2 gene and its relationship with body size traits in Qinchuan cattle (Bos taurus). | Gui LS et al. | β | 2015 | β |
| Functional Characterization of a Single Nucleotide Polymorphism in the 3' Untranslated Region of Sheep DLX3 Gene. | Rong E et al. | β | 2015 | β |
| Functional verification of a porcine myostatin propeptide mutant. | Ma D et al. | β | 2015 | β |
| Gene co-expression network analysis provides novel insights into myostatin regulation at three different mouse developmental timepoints. | Yang X et al. | β | 2015 | β |
| Genetic variability of microRNA regulome in human. | Obsteter J et al. | β | 2015 | β |
| Genome edited sheep and cattle. | Proudfoot C et al. | β | 2015 | β |
| Genome-scale identification of miRNA-mRNA and miRNA-lncRNA interactions in domestic animals. | Li A et al. | β | 2015 | β |
| Genome-wide evolutionary and functional analysis of the Equine Repetitive Element 1: an insertion in the myostatin promoter affects gene expression. | Santagostino M et al. | β | 2015 | β |
| Growth Differentiation Factor-8 Decreases StAR Expression Through ALK5-Mediated Smad3 and ERK1/2 Signaling Pathways in Luteinized Human Granulosa Cells. | Fang L et al. | β | 2015 | β |
| Haplotype distribution in the class I sirtuin genes and their associations with ultrasound carcass traits in Qinchuan cattle (Bos taurus). | Gui L et al. | β | 2015 | β |
| Harnessing cross-species alignment to discover SNPs and generate a draft genome sequence of a bighorn sheep (Ovis canadensis). | Miller JM et al. | β | 2015 | β |
| Identification and analysis of genetic variations in pri-miRNAs expressed specifically or at a high level in sheep skeletal muscle. | Zhang W et al. | β | 2015 | β |
| Identification of a functional SNP in the 3'UTR of CXCR2 that is associated with reduced risk of lung cancer. | Ryan BM et al. | β | 2015 | β |
| Identification of Reproduction-Related Gene Polymorphisms Using Whole Transcriptome Sequencing in the Large White Pig Population. | Fischer D et al. | β | 2015 | β |
| MicroRNA-128 targets myostatin at coding domain sequence to regulate myoblasts in skeletal muscle development. | Shi L et al. | β | 2015 | β |
| MicroRNA-133b inhibits proliferation and invasion of ovarian cancer cells through Akt and Erk1/2 inactivation by targeting epidermal growth factor receptor. | Liu X et al. | β | 2015 | β |
| MicroRNA and mRNA Expression Changes in Steroid NaΓ―ve and Steroid Treated DMD Patients. | Liu DZ et al. | β | 2015 | β |
| microRNAs as Developmental Regulators. | Ivey KN et al. | β | 2015 | β |
| MiR-206, a key modulator of skeletal muscle development and disease. | Ma G et al. | β | 2015 | β |
| miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival. | Yang Y et al. | β | 2015 | β |
| Molecular Characterization of Bovine SMO Gene and Effects of Its Genetic Variations on Body Size Traits in Qinchuan Cattle (Bos taurus). | Zhang YR et al. | β | 2015 | β |
| Muscle hypertrophy induced by myostatin inhibition accelerates degeneration in dysferlinopathy. | Lee YS et al. | β | 2015 | β |
| Myostatin: expanding horizons. | Sharma M et al. | β | 2015 | β |
| Overlapping mouse subcongenic strains successfully separate two linked body fat QTL on distal MMU 2. | Gularte-MΓ©rida R et al. | β | 2015 | β |
| Plasma microRNA levels differ between endurance and strength athletes. | Wardle SL et al. | β | 2015 | β |
| Polymorphisms in DCDC2 and S100B associate with developmental dyslexia. | Matsson H et al. | β | 2015 | β |
| Prediction of MicroRNA-Disease Associations Based on Social Network Analysis Methods. | Zou Q et al. | β | 2015 | β |
| Regulation of skeletal muscle development and disease by microRNAs. | Liu N et al. | β | 2015 | β |
| RNA sequencing identifies upregulated kyphoscoliosis peptidase and phosphatidic acid signaling pathways in muscle hypertrophy generated by transgenic expression of myostatin propeptide. | Miao Y et al. | β | 2015 | β |
| Satellite cells in human skeletal muscle plasticity. | Snijders T et al. | β | 2015 | β |
| Signals of Ezh2, Src, and Akt Involve in myostatin-Pax7 pathways regulating the myogenic fate determination during the sheep myoblast proliferation and differentiation. | Wei C et al. | β | 2015 | β |
| Skeletal Muscle MicroRNAs: Their Diagnostic and Therapeutic Potential in Human Muscle Diseases. | Alexander MS et al. | β | 2015 | β |
| SNP in pre-miR-1666 decreases mature miRNA expression and is associated with chicken performance. | Wang SH et al. | β | 2015 | β |
| SNPs in APOBEC3 cytosine deaminases and their association with Visna/Maedi disease progression. | Esparza-Baquer A et al. | β | 2015 | β |
| Stable suppression of myostatin gene expression in goat fetal fibroblast cells by lentiviral vector-mediated RNAi. | Patel UA et al. | β | 2015 | β |
| Systems biology analysis merging phenotype, metabolomic and genomic data identifies Non-SMC Condensin I Complex, Subunit G (NCAPG) and cellular maintenance processes as major contributors to genetic variability in bovine feed efficiency. | Widmann P et al. | β | 2015 | β |
| Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs. | Qian L et al. | β | 2015 | β |
| The Extent of mRNA Editing Is Limited in Chicken Liver and Adipose, but Impacted by Tissular Context, Genotype, Age, and Feeding as Exemplified with a Conserved Edited Site in COG3. | Roux PF et al. | β | 2015 | β |
| The Genetic Architecture of Domestication in Animals. | Wright D | β | 2015 | β |
| The mesmiRizing complexity of microRNAs for striated muscle tissue engineering. | Quattrocelli M et al. | β | 2015 | β |
| The miR-149 rs2292832 T/C polymorphism may decrease digestive cancer susceptibility: an updated meta-analysis. | Li L et al. | β | 2015 | β |
| The miRNA Transcriptome Directly Reflects the Physiological and Biochemical Differences between Red, White, and Intermediate Muscle Fiber Types. | Ma J et al. | β | 2015 | β |
| Transcriptome analysis of post-hatch breast muscle in legacy and modern broiler chickens reveals enrichment of several regulators of myogenic growth. | Davis RV et al. | β | 2015 | β |
| Two Mutations in the Caprine MTHFR 3'UTR Regulated by MicroRNAs Are Associated with Milk Production Traits. | Hou J et al. | β | 2015 | β |
| Adaptive evolution of testis-specific, recently evolved, clustered miRNAs in Drosophila. | Mohammed J et al. | β | 2014 | β |
| Advancements in stem cells treatment of skeletal muscle wasting. | Meregalli M et al. | β | 2014 | β |
| A functional MiR-124 binding-site polymorphism in IQGAP1 affects human cognitive performance. | Yang L et al. | β | 2014 | β |
| A functional polymorphism in the promoter region of microRNA-146a is associated with the risk of Alzheimer disease and the rate of cognitive decline in patients. | Cui L et al. | β | 2014 | β |
| Allele-specific regulation of DISC1 expression by miR-135b-5p. | Rossi M et al. | β | 2014 | β |
| Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells. | Horiba T et al. | β | 2014 | β |
| An antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy. | Lach-Trifilieff E et al. | β | 2014 | β |
| A new single nucleotide polymorphism in the rabbit (Oryctolagus cuniculus) myostatin (MSTN) gene is associated with carcass composition traits. | Sternstein I et al. | β | 2014 | β |
| Application of <i>myostatin</i> in sheep breeding programs: A review. | Miar Y et al. | β | 2014 | β |
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| Association study of a common genetic variant in pre-miR-1596 with chicken performance traits. | Li H et al. | β | 2014 | β |
| CARP, a myostatin-downregulated gene in CFM Cells, is a novel essential positive regulator of myogenesis. | Ma G et al. | β | 2014 | β |
| Co-expression analysis of fetal weight-related genes in ovine skeletal muscle during mid and late fetal development stages. | Xu L et al. | β | 2014 | β |
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| Effects of genetic variations on microRNA: target interactions. | Liu C et al. | β | 2014 | β |
| Electrical stimulation counteracts muscle decline in seniors. | Kern H et al. | β | 2014 | β |
| Endocrine crosstalk between muscle and bone. | Brotto M et al. | β | 2014 | β |
| Enhanced skeletal muscle for effective glucose homeostasis. | Yang J | β | 2014 | β |
| Evaluation of Columbia, U.S. Meat Animal Research Center Composite, Suffolk, and Texel rams as terminal sires in an extensive rangeland production system: VI. Measurements of live-lamb and carcass shape and their relationship to carcass yield and value. | Notter DR et al. | β | 2014 | β |
| Extensive sequence variation in the 3' untranslated region of the KRAS gene in lung and ovarian cancer cases. | Kim M et al. | β | 2014 | β |
| Generation of myostatin B knockout yellow catfish (Tachysurus fulvidraco) using transcription activator-like effector nucleases. | Dong Z et al. | β | 2014 | β |
| Genome-wide scan reveals LEMD3 and WIF1 on SSC5 as the candidates for porcine ear size. | Zhang L et al. | β | 2014 | β |
| Genome-wide SNP scan in a porcine Large WhiteΓMinzhu intercross population reveals a locus influencing muscle mass on chromosome 2. | Liu X et al. | β | 2014 | β |
| Identification of a new target of miR-16, Vacuolar Protein Sorting 4a. | Adhikari N et al. | β | 2014 | β |
| Identification of QTLs for behavioral reactivity to social separation and humans in sheep using the OvineSNP50 BeadChip. | Hazard D et al. | β | 2014 | β |
| Identification of selection signatures in livestock species. | de Simoni Gouveia JJ et al. | β | 2014 | β |
| Knockdown of endogenous myostatin promotes sheep myoblast proliferation. | Liu C et al. | β | 2014 | β |
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| MicroRNA-146a and Ets-1 gene polymorphisms are associated with pediatric uveitis. | Wei L et al. | β | 2014 | β |
| MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome. | Zhou Q et al. | β | 2014 | β |
| MicroRNA-27a promotes porcine myoblast proliferation by downregulating myostatin expression. | Yang T et al. | β | 2014 | β |
| MicroRNA-7 inhibits tumor metastasis and reverses epithelial-mesenchymal transition through AKT/ERK1/2 inactivation by targeting EGFR in epithelial ovarian cancer. | Zhou X et al. | β | 2014 | β |
| MicroRNA binding site polymorphisms as biomarkers in cancer management and research. | Cipollini M et al. | β | 2014 | β |
| MicroRNA dysregulation as a prognostic biomarker in colorectal cancer. | Dong Y et al. | β | 2014 | β |
| MicroRNA in skeletal muscle development, growth, atrophy, and disease. | Kovanda A et al. | β | 2014 | β |
| MicroRNA in teleost fish. | Bizuayehu TT et al. | β | 2014 | β |
| MicroRNA-mediated myostatin silencing in caprine fetal fibroblasts. | Zhong B et al. | β | 2014 | β |
| MicroRNAs and human diseases: diagnostic and therapeutic potential. | Maqbool R et al. | β | 2014 | β |
| MicroRNAs: history, biogenesis, and their evolving role in animal development and disease. | Bhaskaran M et al. | β | 2014 | β |
| Mining the 3'UTR of autism-implicated genes for SNPs perturbing microRNA regulation. | Vaishnavi V et al. | β | 2014 | β |
| miRNAs as biomarkers of myocardial infarction: a step forward towards personalized medicine? | Goretti E et al. | β | 2014 | β |
| Molecular and cell-based therapies for muscle degenerations: a road under construction. | Berardi E et al. | β | 2014 | β |
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| Myostatin and the skeletal muscle atrophy and hypertrophy signaling pathways. | Rodriguez J et al. | β | 2014 | β |
| Myostatin signaling regulates Akt activity via the regulation of miR-486 expression. | Hitachi K et al. | β | 2014 | β |
| Negative auto-regulation of myostatin expression is mediated by Smad3 and microRNA-27. | McFarlane C et al. | β | 2014 | β |
| Polymorphism in 3' untranslated region of the pig PPARA gene influences its transcript level and is associated with adipose tissue accumulation. | Stachowiak M et al. | β | 2014 | β |
| Promoter polymorphisms in genes involved in porcine myogenesis influence their transcriptional activity. | Bongiorni S et al. | β | 2014 | β |
| Propeptide-mediated inhibition of myostatin increases muscle mass through inhibiting proteolytic pathways in aged mice. | Collins-Hooper H et al. | β | 2014 | β |
| Relationships among body composition, circulating concentrations of leptin and follistatin, and the onset of puberty and fertility in young female sheep. | Rosales Nieto CA et al. | β | 2014 | β |
| Re-sequencing data for refining candidate genes and polymorphisms in QTL regions affecting adiposity in chicken. | Roux PF et al. | β | 2014 | β |
| Selection in action: dissecting the molecular underpinnings of the increasing muscle mass of Belgian Blue Cattle. | Druet T et al. | β | 2014 | β |
| Selection signatures in worldwide sheep populations. | Fariello MI et al. | β | 2014 | β |
| Single nucleotide polymorphism-specific regulation of matrix metalloproteinase-9 by multiple miRNAs targeting the coding exon. | Duellman T et al. | β | 2014 | β |
| Small interfering RNA (siRNA)-mediated knockdown of myostatin influences the expression of myogenic regulatory factors in caprine foetal myoblasts. | Kumar R et al. | β | 2014 | β |
| TGFΞ² and BMP signaling in skeletal muscle: potential significance for muscle-related disease. | Sartori R et al. | β | 2014 | β |
| The A55T and K153R polymorphisms of MSTN gene are associated with the strength training-induced muscle hypertrophy among Han Chinese men. | Li X et al. | β | 2014 | β |
| The role of microRNAs in human diseases. | TΓΌfekci KU et al. | β | 2014 | β |
| The sheep genome illuminates biology of the rumen and lipid metabolism. | Jiang Y et al. | β | 2014 | β |
| Transcript level of the porcine ME1 gene is affected by SNP in its 3'UTR, which is also associated with subcutaneous fat thickness. | Bartz M et al. | β | 2014 | β |
| Validation of miRNA genes suitable as reference genes in qPCR analyses of miRNA gene expression in Atlantic salmon (Salmo salar). | Johansen I et al. | β | 2014 | β |
| Variation in the ovine WFIKKN2 gene. | Wang J et al. | β | 2014 | β |
| A miR-151 binding site polymorphism in the 3'-untranslated region of the cyclin E1 gene associated with nasopharyngeal carcinoma. | Liu Y et al. | β | 2013 | β |
| An EAV-HP insertion in 5' Flanking region of SLCO1B3 causes blue eggshell in the chicken. | Wang Z et al. | β | 2013 | β |
| Anti-microbial peptide (AMP): nucleotide variation, gene expression, and host resistance in the white pine blister rust (WPBR) pathosystem. | Liu JJ et al. | β | 2013 | β |
| Are differences in microRNA regulation implicated in species-dependent response to toxicological exposures? | Koufaris C et al. | β | 2013 | β |
| A single-nucleotide polymorphism in the 3' untranslated region of the LPIN1 gene and association analysis with performance traits in chicken. | Zhang SP et al. | β | 2013 | β |
| A SNP in the 5' flanking region of the myostatin-1b gene is associated with harvest traits in Atlantic salmon (Salmo salar). | PeΓ±aloza C et al. | β | 2013 | β |
| A systems biology approach using metabolomic data reveals genes and pathways interacting to modulate divergent growth in cattle. | Widmann P et al. | β | 2013 | β |
| CEBPG Exhibits Allele-Specific Expression in Human Bronchial Epithelial Cells. | Blomquist TM et al. | β | 2013 | β |
| Cellular and molecular mechanisms of muscle atrophy. | Bonaldo P et al. | β | 2013 | β |
| Combined microRNA in situ hybridization and immunohistochemical detection of protein markers. | Nielsen BS et al. | β | 2013 | β |
| Computational prediction of the localization of microRNAs within their pre-miRNA. | Leclercq M et al. | β | 2013 | β |
| Detecting regions of homozygosity to map the cause of recessively inherited disease. | Kijas JW | β | 2013 | β |
| Detecting signatures of selection through haplotype differentiation among hierarchically structured populations. | Fariello MI et al. | β | 2013 | β |
| Discovery and characterization of miRNA genes in Atlantic salmon (Salmo salar) by use of a deep sequencing approach. | Andreassen R et al. | β | 2013 | β |
| Effect of the myostatin locus on muscle mass and intramuscular fat content in a cross between mouse lines selected for hypermuscularity. | KΓ€rst S et al. | β | 2013 | β |
| EGFR 3'UTR 774T>C polymorphism contributes to bladder cancer risk. | Chu H et al. | β | 2013 | β |
| Evaluation of Columbia, USMARC-Composite, Suffolk, and Texel rams as terminal sires in an extensive rangeland production system: IV. Postfabrication carcass component weights. | Mousel MR et al. | β | 2013 | β |
| Expanding possibilities for intervention against small ruminant lentiviruses through genetic marker-assisted selective breeding. | White SN et al. | β | 2013 | β |
| Functional effect of mir-27b on myostatin expression: a relationship in Piedmontese cattle with double-muscled phenotype. | Miretti S et al. | β | 2013 | β |
| Gene-based single nucleotide polymorphism discovery in bovine muscle using next-generation transcriptomic sequencing. | Djari A et al. | β | 2013 | β |
| Genetic factors controlling wool shedding in a composite Easycare sheep flock. | Matika O et al. | β | 2013 | β |
| Genetic variations in the myostatin gene (MSTN) in New Zealand sheep breeds. | Han J et al. | β | 2013 | β |
| Genome-wide analysis reveals selection for important traits in domestic horse breeds. | Petersen JL et al. | β | 2013 | β |
| Genome-wide association studies for growth and meat production traits in sheep. | Zhang L et al. | β | 2013 | β |
| Genome-wide in silico screening for microRNA genetic variability in livestock species. | Jevsinek Skok D et al. | β | 2013 | β |
| Grafting of a single donor myofibre promotes hypertrophy in dystrophic mouse muscle. | Boldrin L et al. | β | 2013 | β |
| Human susceptibility to legionnaires' disease. | Berrington WR et al. | β | 2013 | β |
| Identification and characterization of the miRNA transcriptome of Ovis aries. | Zhang S et al. | β | 2013 | β |
| Identification of differences in microRNA transcriptomes between porcine oxidative and glycolytic skeletal muscles. | Liu Y et al. | β | 2013 | β |
| Inhibition of myostatin gene expression in skeletal muscle of fish by in vivo electrically mediated dsRNA and shRNAi delivery. | Terova G et al. | β | 2013 | β |
| Knockdown of myostatin expression by RNAi enhances muscle growth in transgenic sheep. | Hu S et al. | β | 2013 | β |
| Lack of association between allelic status and myostatin content in lambs with the myostatin g+6723G>A allele. | Haynes FE et al. | β | 2013 | β |
| Maternal and paternal genomes differentially affect myofibre characteristics and muscle weights of bovine fetuses at midgestation. | Xiang R et al. | β | 2013 | β |
| Meat science: From proteomics to integrated omics towards system biology. | D'Alessandro A et al. | β | 2013 | β |
| MicroRNAs in domestic livestock. | Fatima A et al. | β | 2013 | β |
| MicroRNAs in farm animals. | Wang X et al. | β | 2013 | β |
| MicroRNAs involved in skeletal muscle differentiation. | Luo W et al. | β | 2013 | β |
| miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4. | Winbanks CE et al. | β | 2013 | β |
| Molecular cloning and characterization of a cathepsin B gene from the Chinese shrimp Fenneropenaeus chinensis. | Li X et al. | β | 2013 | β |
| Molecular consequences of animal breeding. | Andersson L | β | 2013 | β |
| Muscle-specific transgenic expression of porcine myostatin propeptide enhances muscle growth in mice. | Wang K et al. | β | 2013 | β |
| Myostatin/activin pathway antagonism: molecular basis and therapeutic potential. | Han HQ et al. | β | 2013 | β |
| Myostatin acts as an autocrine/paracrine negative regulator in myoblast differentiation from human induced pluripotent stem cells. | Gao F et al. | β | 2013 | β |
| Numb-deficient satellite cells have regeneration and proliferation defects. | George RM et al. | β | 2013 | β |
| Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx. | Guan X et al. | β | 2013 | β |
| Prioritization of genetic variants in the microRNA regulome as functional candidates in genome-wide association studies. | Bulik-Sullivan B et al. | β | 2013 | β |
| REV3L 3'UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility. | Zhang S et al. | β | 2013 | β |
| RNA sequencing reveals small RNAs differentially expressed between incipient Japanese threespine sticklebacks. | Kitano J et al. | β | 2013 | β |
| Role of microRNAs in skeletal muscle hypertrophy. | Hitachi K et al. | β | 2013 | β |
| Short communication: a mutation in the 3' untranslated region diminishes microRNA binding and alters expression of the OLR1 gene. | Wang X et al. | β | 2013 | β |
| Single modification at position 14 of siRNA strand abolishes its gene-silencing activity by decreasing both RISC loading and target degradation. | Zheng J et al. | β | 2013 | β |
| Single nucleotide polymorphisms in the upstream regulatory region alter the expression of myostatin. | Hu W et al. | β | 2013 | β |
| SIRT1 gene polymorphisms are associated with growth traits in Nanyang cattle. | Li M et al. | β | 2013 | β |
| SNPing cancer in the bud: microRNA and microRNA-target site polymorphisms as diagnostic and prognostic biomarkers in cancer. | Salzman DW et al. | β | 2013 | β |
| SNPs of MYPN and TTN genes are associated to meat and carcass traits in Italian Large White and Italian Duroc pigs. | Braglia S et al. | β | 2013 | β |
| Systems biology and livestock production. | Headon D | β | 2013 | β |
| Targeted Myostatin Gene Editing in Multiple Mammalian Species Directed by a Single Pair of TALE Nucleases. | Xu L et al. | β | 2013 | β |
| The compact mutation of myostatin causes a glycolytic shift in the phenotype of fast skeletal muscles. | BaΓ‘n JA et al. | β | 2013 | β |
| The effect of myostatin silencing by lentiviral-mediated RNA interference on goat fetal fibroblasts. | Lu J et al. | β | 2013 | β |
| The effects of the myostatin g+6723G>A mutation on carcass and meat quality of lamb. | Hope M et al. | β | 2013 | β |
| The G32E functional variant reduces activity of PPARD by nuclear export and post-translational modification in pigs. | Duan Y et al. | β | 2013 | β |
| The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GALNT2 gene within the ovary. | Drouilhet L et al. | β | 2013 | β |
| Variants in the 3' UTR of general Transcription factor IIF, polypeptide 2 affect female calving efficiency in Japanese Black cattle. | Sasaki S et al. | β | 2013 | β |
| ACVR1, a therapeutic target of fibrodysplasia ossificans progressiva, is negatively regulated by miR-148a. | Song H et al. | β | 2012 | β |
| Analysis of multiple polymorphisms in the bovine neuropeptide Y5 receptor gene and structural modelling of the encoded protein. | Alam T et al. | β | 2012 | β |
| An asymmetric PCR-based, reliable and rapid single-tube native DNA engineering strategy. | Bi Y et al. | β | 2012 | β |
| A promoter polymorphism of MSTN g.-371T>A and its associations with carcass traits in Korean cattle. | Han SH et al. | β | 2012 | β |
| A single nucleotide polymorphism in the acetyl-coenzyme A acyltransferase 2 (ACAA2) gene is associated with milk yield in Chios sheep. | Orford M et al. | β | 2012 | β |
| Associations of fibroblast growth factor 21 gene 3' untranslated region single-nucleotide polymorphisms with metabolic syndrome, obesity, and diabetes in a Han Chinese population. | Zhang M et al. | β | 2012 | β |
| Cachexia and sarcopenia: emerging syndromes of importance in dogs and cats. | Freeman LM | β | 2012 | β |
| Cell-type specific regulation of myostatin signaling. | Kemaladewi DU et al. | β | 2012 | β |
| Characterization of a myostatin gene (MSTN1) from spotted halibut (Verasper variegatus) and association between its promoter polymorphism and individual growth performance. | Li H et al. | β | 2012 | β |
| Combined effect of AAV-U7-induced dystrophin exon skipping and soluble activin Type IIB receptor in mdx mice. | Hoogaars WM et al. | β | 2012 | β |
| Comprehensive exploration of the effects of miRNA SNPs on monocyte gene expression. | Greliche N et al. | β | 2012 | β |
| Effects of breed of sire on carcass composition and sensory traits of lamb. | Shackelford SD et al. | β | 2012 | β |
| Effects of polymorphisms in the porcine microRNA miR-1 locus on muscle fiber type composition and miR-1 expression. | Hong JS et al. | β | 2012 | β |
| Evaluation of Columbia, USMARC-Composite, Suffolk, and Texel rams as terminal sires in an extensive rangeland production system: III. Prefabrication carcass traits and organ weights. | Mousel MR et al. | β | 2012 | β |
| Evaluation of Columbia, USMARC-Composite, Suffolk, and Texel rams as terminal sires in an extensive rangeland production system: II. Postweaning growth and ultrasonic measures of composition for lambs fed a high-energy feedlot diet. | Notter DR et al. | β | 2012 | β |
| Expression of small RNA in Aphis gossypii and its potential role in the resistance interaction with melon. | Sattar S et al. | β | 2012 | β |
| Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin. | Winbanks CE et al. | β | 2012 | β |
| Functional expression of an orchid fragrance gene in Lactococcus lactis. | Song AAL et al. | β | 2012 | β |
| Genes contributing to genetic variation of muscling in sheep. | Tellam RL et al. | β | 2012 | β |
| Genome-wide analysis of the world's sheep breeds reveals high levels of historic mixture and strong recent selection. | Kijas JW et al. | β | 2012 | β |
| Identification and comparative analysis of the Eriocheir sinensis microRNA transcriptome response to Spiroplasma eriocheiris infection using a deep sequencing approach. | Ou J et al. | β | 2012 | β |
| Identification of common carp (Cyprinus carpio) microRNAs and microRNA-related SNPs. | Zhu YP et al. | β | 2012 | β |
| Identification of decorin derived peptides with a zinc dependent anti-myostatin activity. | Guiraud S et al. | β | 2012 | β |
| Identification of fifteen novel germline variants in the BRCA1 3'UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site. | Brewster BL et al. | β | 2012 | β |
| Impact of microRNA regulation on variation in human gene expression. | Lu J et al. | β | 2012 | β |
| Induction of microRNA-155 is TLR- and type IV secretion system-dependent in macrophages and inhibits DNA-damage induced apoptosis. | Koch M et al. | β | 2012 | β |
| Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice. | Zhang C et al. | β | 2012 | β |
| Lack of association of miR-146a and Ets-1 gene polymorphisms with Fuchs uveitis syndrome in Chinese Han patients. | Zhou Q et al. | β | 2012 | β |
| Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens. | Lin S et al. | β | 2012 | β |
| Lost in translation: regulation of skeletal muscle protein synthesis. | Weigl LG | β | 2012 | β |
| Methods to detect selection on noncoding DNA. | Zhen Y et al. | β | 2012 | β |
| MicroRNA-182 regulates otocyst-derived cell differentiation and targets T-box1 gene. | Wang XR et al. | β | 2012 | β |
| MicroRNA-27a promotes myoblast proliferation by targeting myostatin. | Huang Z et al. | β | 2012 | β |
| MicroRNA-7 inhibits tumor growth and metastasis by targeting the phosphoinositide 3-kinase/Akt pathway in hepatocellular carcinoma. | Fang Y et al. | β | 2012 | β |
| MicroRNA-mediated regulation of gene expression is affected by disease-associated SNPs within the 3'-UTR via altered RNA structure. | Haas U et al. | β | 2012 | β |
| MicroRNAs in neurodegenerative diseases and their therapeutic potential. | Junn E et al. | β | 2012 | β |
| microRNAs in skeletal muscle differentiation and disease. | Goljanek-Whysall K et al. | β | 2012 | β |
| MicroRNAs in stress signaling and human disease. | Mendell JT et al. | β | 2012 | β |
| miR-421 and miR-30c inhibit SERPINE 1 gene expression in human endothelial cells. | Marchand A et al. | β | 2012 | β |
| miRNA, development and disease. | Amiel J et al. | β | 2012 | β |
| Modeling SNP mediated differential targeting of homologous 3'UTR by microRNA. | Ahluwalia JK et al. | β | 2012 | β |
| Molecular characterization of myostatin (MSTN) gene and association analysis with growth traits in the bighead carp (Aristichthys nobilis). | Liu L et al. | β | 2012 | β |
| Molecular genetic studies of gene identification for sarcopenia. | Tan LJ et al. | β | 2012 | β |
| Muscle function in COPD: a complex interplay. | Donaldson AV et al. | β | 2012 | β |
| Myostatin allelic status interacts with level of nutrition to affect growth, composition, and myofiber characteristics of lambs. | Haynes FE et al. | β | 2012 | β |
| Myostatin deficiency is associated with an increase in number of total axons and motor axons innervating mouse tibialis anterior muscle. | Gay S et al. | β | 2012 | β |
| Myostatin inhibition induces muscle fibre hypertrophy prior to satellite cell activation. | Wang Q et al. | β | 2012 | β |
| Next-generation sequencing of the porcine skeletal muscle transcriptome for computational prediction of microRNA gene targets. | McDaneld TG et al. | β | 2012 | β |
| Organization and functional analysis of the 5' flanking regions of myostatin-1 and 2 genes from Larimichthys crocea. | Xue L et al. | β | 2012 | β |
| Polymorphisms in the ovine myostatin gene are associated with birth weight but not with weight gain in Iranian Makoei sheep. | Farhadian M et al. | β | 2012 | β |
| Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease. | Zhi H et al. | β | 2012 | β |
| Prediction of altered 3'- UTR miRNA-binding sites from RNA-Seq data: the swine leukocyte antigen complex (SLA) as a model region. | Endale Ahanda ML et al. | β | 2012 | β |
| Production of transgenic calves expressing an shRNA targeting myostatin. | Tessanne K et al. | β | 2012 | β |
| QTL mapping for sexually dimorphic fitness-related traits in wild bighorn sheep. | Poissant J et al. | β | 2012 | β |
| RNA-Seq identifies SNP markers for growth traits in rainbow trout. | Salem M et al. | β | 2012 | β |
| Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway. | Lee SJ et al. | β | 2012 | β |
| Selection of an effective small interference RNA to silence myostatin gene expression in sheep fibroblast cells. | Lu J et al. | β | 2012 | β |
| Site-directed mutagenesis of the myostatin gene in ovine fetal myoblast cells in vitro. | Zheng YL et al. | β | 2012 | β |
| The association of genetic variations in the promoter region of myostatin gene with growth traits in Duroc pigs. | Tu PA et al. | β | 2012 | β |
| The critical role of myostatin in differentiation of sheep myoblasts. | Liu C et al. | β | 2012 | β |
| The paradox of muscle hypertrophy in muscular dystrophy. | Kornegay JN et al. | β | 2012 | β |
| A global view of porcine transcriptome in three tissues from a full-sib pair with extreme phenotypes in growth and fat deposition by paired-end RNA sequencing. | Chen C et al. | β | 2011 | β |
| A miRNA-492 binding-site polymorphism in BSG (basigin) confers risk to psoriasis in central south Chinese population. | Wu LS et al. | β | 2011 | β |
| A missense mutation in PPARD causes a major QTL effect on ear size in pigs. | Ren J et al. | β | 2011 | β |
| Analysis of the single-nucleotide polymorphism in the 5'UTR and part of intron I of the sheep MSTN gene. | Sjakste T et al. | β | 2011 | β |
| An SNP within the angiotensin-converting enzyme distinguishes between sprint and distance performing Alaskan sled dogs in a candidate gene analysis. | Huson HJ et al. | β | 2011 | β |
| A SNP in the miR-27a gene is associated with litter size in pigs. | Lei B et al. | β | 2011 | β |
| Cattle gain stature. | Visscher PM et al. | β | 2011 | β |
| Characterization of microRNAs from sheep (Ovis aries) using computational and experimental analyses. | Sheng X et al. | β | 2011 | β |
| Cryptic patterning of avian skin confers a developmental facility for loss of neck feathering. | Mou C et al. | β | 2011 | β |
| Deciphering the genetic basis of animal domestication. | Wiener P et al. | β | 2011 | β |
| Differential allelic expression of c.1568C > A at UGT2B15 is due to variation in a novel cis-regulatory element in the 3'UTR. | Sun C et al. | β | 2011 | β |
| Differential expression of microRNA-206 in skeletal muscle of female Piedmontese and Friesian cattle. | Miretti S et al. | β | 2011 | β |
| Dual exon skipping in myostatin and dystrophin for Duchenne muscular dystrophy. | Kemaladewi DU et al. | β | 2011 | β |
| Dysregulation of microRNAs in cancer: playing with fire. | Melo SA et al. | β | 2011 | β |
| Effects of microRNA-143 in the differentiation and proliferation of bovine intramuscular preadipocytes. | Li H et al. | β | 2011 | β |
| Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure. | Zamani N et al. | β | 2011 | β |
| Evolution of microRNA diversity and regulation in animals. | Berezikov E | β | 2011 | β |
| Evolution of microRNAs and the diversification of species. | Loh YH et al. | β | 2011 | β |
| Fine-mapping of quantitative trait loci for body weight and bone traits and positional cloning of the RB1 gene in chicken. | Zhang H et al. | β | 2011 | β |
| Follistatin-derived peptide expression in muscle decreases adipose tissue mass and prevents hepatic steatosis. | Nakatani M et al. | β | 2011 | β |
| Gene expression profiling of skeletal muscles treated with a soluble activin type IIB receptor. | Rahimov F et al. | β | 2011 | β |
| Genome-wide impact of a recently expanded microRNA cluster in mouse. | Zheng GX et al. | β | 2011 | β |
| Glutamine prevents myostatin hyperexpression and protein hypercatabolism induced in C2C12 myotubes by tumor necrosis factor-Ξ±. | Bonetto A et al. | β | 2011 | β |
| Heart failure: advances through genomics. | Creemers EE et al. | β | 2011 | β |
| Histological and transcriptome-wide level characteristics of fetal myofiber hyperplasia during the second half of gestation in Texel and Ujumqin sheep. | Ren H et al. | β | 2011 | β |
| Identification and genetic effect of haplotypes in the promoter region of porcine myostatin gene. | Liu D et al. | β | 2011 | β |
| Identification of polymorphisms in the rabbit (Oryctolagus cuniculus) myostatin (MSTN) gene and association analysis with finishing weight in a commercial rabbit population. | Fontanesi L et al. | β | 2011 | β |
| Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice. | Lawlor MW et al. | β | 2011 | β |
| Inhibition of miR-214 expression represses proliferation and differentiation of C2C12 myoblasts. | Feng Y et al. | β | 2011 | β |
| In silico identification of microRNAs predicted to regulate the drug metabolizing cytochrome P450 genes. | Ramamoorthy A et al. | β | 2011 | β |
| Localization of Magic-F1 transgene, involved in muscular hypertrophy, during early myogenesis. | Ronzoni F et al. | β | 2011 | β |
| Mapping genetic loci that interact with myostatin to affect growth traits. | Cheng Y et al. | β | 2011 | β |
| Mechanisms limiting body growth in mammals. | Lui JC et al. | β | 2011 | β |
| MicroRNAs: miRRORS of health and disease. | Montano M | β | 2011 | β |
| Mutations in the myostatin gene leading to hypermuscularity in mammals: indications for a similar mechanism in fish? | Stinckens A et al. | β | 2011 | β |
| Myostatin-2 gene structure and polymorphism of the promoter and first intron in the marine fish Sparus aurata: evidence for DNA duplications and/or translocations. | Nadjar-Boger E et al. | β | 2011 | β |
| Myostatin: a novel insight into its role in metabolism, signal pathways, and expression regulation. | Huang Z et al. | β | 2011 | β |
| Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway. | Zhang C et al. | β | 2011 | β |
| Myostatin inactivation increases myotube size through regulation of translational initiation machinery. | Rodriguez J et al. | β | 2011 | β |
| Myostatin promotes the wasting of human myoblast cultures through promoting ubiquitin-proteasome pathway-mediated loss of sarcomeric proteins. | Lokireddy S et al. | β | 2011 | β |
| Myostatin up-regulation is associated with the skeletal muscle response to hypoxic stimuli. | Hayot M et al. | β | 2011 | β |
| Non-coding RNAs as regulators of embryogenesis. | Pauli A et al. | β | 2011 | β |
| Non-coding RNAs in human disease. | Esteller M | β | 2011 | β |
| Pervasive roles of microRNAs in cardiovascular biology. | Small EM et al. | β | 2011 | β |
| Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease. | Zhang L et al. | β | 2011 | β |
| Posttranscriptional mechanisms involving microRNA-27a and b contribute to fast-specific and glucocorticoid-mediated myostatin expression in skeletal muscle. | Allen DL et al. | β | 2011 | β |
| Production of bioactive rockfish (Sebastes schlegeli) myostatin-1 prodomain in an Escherichia coli system. | Lee SB et al. | β | 2011 | β |
| Proteolysis in illness-associated skeletal muscle atrophy: from pathways to networks. | Wing SS et al. | β | 2011 | β |
| RNA surveillance-an emerging role for RNA regulatory networks in aging. | Montano M et al. | β | 2011 | β |
| Role of TGF-Ξ² signaling in inherited and acquired myopathies. | Burks TN et al. | β | 2011 | β |
| Selection based on progeny testing induces rapid changes in myostatin allele frequencies - a case study in sheep. | Boman IA et al. | β | 2011 | β |
| Selective inhibition of microRNA accessibility by RBM38 is required for p53 activity. | LΓ©veillΓ© N et al. | β | 2011 | β |
| Single Nucleotide Polymorphisms in the Insulin-Like Growth Factor 1 (IGF-1) Gene are Associated with Performance in Holstein-Friesian Dairy Cattle. | Mullen MP et al. | β | 2011 | β |
| Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. | Diouf B et al. | β | 2011 | β |
| Structural and functional characterisation of the ovine interferon gamma (IFNG) gene: its role in nematode resistance in Rasa Aragonesa ewes. | Dervishi E et al. | β | 2011 | β |
| Targeting the myostatin signaling pathway to treat muscle wasting diseases. | Han HQ et al. | β | 2011 | β |
| Temporal microRNA expression during in vitro myogenic progenitor cell proliferation and differentiation: regulation of proliferation by miR-682. | Chen Y et al. | β | 2011 | β |
| The 3q29 microdeletion syndrome: report of three new unrelated patients and in silico "RNA binding" analysis of the 3q29 region. | Dasouki MJ et al. | β | 2011 | β |
| The AVPR1A gene and substance use disorders: association, replication, and functional evidence. | Maher BS et al. | β | 2011 | β |
| The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs. | Schlesinger J et al. | β | 2011 | β |
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