Association of GABRG3 with alcohol dependence.
paper
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Public
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- Authors
- Dick, Danielle M; Edenberg, Howard J; Xuei, Xiaoling; Goate, Alison; Kuperman, Sam; Schuckit, Marc; Crowe, Raymond; Smith, Tom L; Porjesz, Bernice; Begleiter, Henri; Foroud, Tatiana
- Year
- 2004
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 14745296
- DOI
- 10.1097/01.ALC.0000108645.54345.98
BACKGROUND: Evidence from human, animal, and in vitro cell models suggests that gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the human central nervous system, is involved in many of the neurochemical pathways that affect alcohol use, abuse, and dependence. Both linkage and association to the region on chromosome 15q that contains a cluster of GABAA receptor genes have previously been reported, but the role of these genes in alcoholism remains inconclusive. METHODS: We conducted family-based association analyses by using a large sample of multiplex alcoholic families collected as part of the Collaborative Study on the Genetics of Alcoholism, to test for an association between alcohol dependence and the GABAA receptor genes clustered on chromosome 15q. Multiple single-nucleotide polymorphisms were tested in each of the three chromosome 15q GABAA receptor genes: GABRA5, GABRB3, and GABRG3. RESULTS: Using both classic trio-based analyses and extended-family analyses, we found consistent evidence of association between alcohol dependence and GABRG3. Nearly all single-nucleotide polymorphisms across the gene yielded evidence of association, and haplotype analyses were highly significant. No consistent evidence of association was observed with either GABRA5 or GABRB3, nor was there evidence for parent-of-origin effects with any of the genes. CONCLUSIONS: These analyses suggest that GABRG3 may be involved in the risk for alcohol dependence. These findings support the theory that the predisposition to alcoholism may be inherited as a general state of central nervous system disinhibition/hyperexcitability that results from an altered responsiveness to GABA.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Theorizing The Role of Gama Type Endorphins in Schizophrenia and Alcoholism: Promoting Genetic Testing and Attempts at Inducing "Dopamine Homeostasis". | Blum K et al. | β | 2025 | β |
| GABA and its receptors' mechanisms in the treatment of insomnia. | Zhu W et al. | β | 2024 | β |
| GABAergic mechanisms in alcohol dependence. | Uusi-Oukari M et al. | β | 2024 | β |
| Paternal cocaine-seeking motivation defines offspring's vulnerability to addiction by down-regulating GABAergic GABRG3 in the ventral tegmental area. | Cui J et al. | β | 2024 | β |
| Paternal Cocaine-Seeking Motivation Defines Offspring's Vulnerability to Addiction by Down-Regulation of GABAergic GABRG3 in the Ventral Tegmental Area | Le Q et al. | β | 2023 | β |
| Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review. | White O et al. | β | 2022 | β |
| Targeting prefrontal cortex GABAergic microcircuits for the treatment of alcohol use disorder. | Fish KN et al. | β | 2022 | β |
| An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population. | Hou SJ et al. | β | 2021 | β |
| Traumatic events during childhood and its risks to substance use in adulthood: an observational and genome-wide by environment interaction study in UK Biobank. | Cheng S et al. | β | 2021 | β |
| The Methylation Pattern for Knee and Hip Osteoarthritis. | Wu Z et al. | β | 2020 | β |
| CIS-Acting Allele-Specific Expression Differences Induced by Alcohol and Impacted by Sex as Well as Parental Genotype of Origin. | Lo CL et al. | β | 2018 | β |
| GABA<sub>A</sub> receptor polymorphisms in alcohol use disorder in the GWAS era. | Koulentaki M et al. | β | 2018 | β |
| GABA<sub>A</sub> Receptor Subtype Mechanisms and the Abuse-Related Effects of Ethanol: Genetic and Pharmacological Evidence. | Chandler CM et al. | β | 2018 | β |
| Neural and psychological characteristics of college students with alcoholic parents differ depending on current alcohol use. | Brown-Rice KA et al. | β | 2018 | β |
| Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story. | Obed A et al. | β | 2018 | β |
| Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems. | Yeung EW et al. | β | 2017 | β |
| Guidelines for biological treatment of substance use and related disorders, part 1: Alcoholism, first revision. | Soyka M et al. | β | 2017 | β |
| Promising pharmacogenetic targets for treating alcohol use disorder: evidence from preclinical models. | Rinker JA et al. | β | 2017 | β |
| A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. | Bell RL et al. | β | 2016 | β |
| More than Meets the Eye: Eye Color and Alcoholism. | Eissenberg JC | β | 2016 | β |
| Autonomic dysfunction determines stress-induced cardiovascular and immune complications in mice. | Batchu SN et al. | β | 2015 | β |
| CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers. | Chen J et al. | β | 2015 | β |
| Multivariate analysis of subjective responses to d-amphetamine in healthy volunteers finds novel genetic pathway associations. | Yarosh HL et al. | β | 2015 | β |
| GABAergic contributions to alcohol responsivity during adolescence: insights from preclinical and clinical studies. | Silveri MM | β | 2014 | β |
| Genetic and environmental interplay in risky drinking in adolescents: a literature review. | Guerrini I et al. | β | 2014 | β |
| Genetics of alcohol dependence: a review of clinical studies. | Samochowiec J et al. | β | 2014 | β |
| Genetics of alcoholism. | Iyer-Eimerbrink PA et al. | β | 2014 | β |
| Genetics of alcoholism. | Edenberg HJ et al. | β | 2014 | β |
| Genetic testing for the susceptibility to alcohol dependence: interest and concerns in an African American population. | Scott DM et al. | β | 2014 | β |
| Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior. | Blum K et al. | β | 2014 | β |
| Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence. | Yan J et al. | β | 2014 | β |
| Consensus paper of the WFSBP task force on biological markers: biological markers for alcoholism. | Hashimoto E et al. | β | 2013 | β |
| Expression of GABAA Ξ±2-, Ξ²1- and Ξ΅-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder. | Fatemi SH et al. | β | 2013 | β |
| Genetically selected alcohol preferring rats to model human alcoholism. | Ciccocioppo R | β | 2013 | β |
| NCK2 is significantly associated with opiates addiction in African-origin men. | Liu Z et al. | β | 2013 | β |
| Alcohol Dependence and Genes Encoding Ξ±2 and Ξ³1 GABAA Receptor Subunits: Insights from Humans and Mice. | Borghese CM et al. | β | 2012 | β |
| Gabra5-gene haplotype block associated with behavioral properties of the full agonist benzodiazepine chlordiazepoxide. | ClΓ©ment Y et al. | β | 2012 | β |
| Genetic epistasis in female suicide attempters. | FernΓ‘ndez-Navarro P et al. | β | 2012 | β |
| Genetics of GABAergic signaling in nicotine and alcohol dependence. | Cui WY et al. | β | 2012 | β |
| Large scale association analysis for drug addiction: results from SNP to gene. | Guo X et al. | β | 2012 | β |
| Zebrafish: a model for the study of addiction genetics. | Klee EW et al. | β | 2012 | β |
| Alcohol research: past, present, and future. | Gunzerath L et al. | β | 2011 | β |
| Genetic traits of avascular necrosis of the femoral head analyzed by array comparative genomic hybridization and real-time polymerase chain reaction. | Hwang JT et al. | β | 2011 | β |
| A cognitive model for the intergenerational transference of alcohol use behavior. | Campbell JM et al. | β | 2010 | β |
| A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality. | Verweij KJ et al. | β | 2010 | β |
| Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats. | Liang T et al. | β | 2010 | β |
| Emerging drugs to treat alcoholism. | Soyka M et al. | β | 2010 | β |
| GABRR1 and GABRR2, encoding the GABA-A receptor subunits rho1 and rho2, are associated with alcohol dependence. | Xuei X et al. | β | 2010 | β |
| Genetic research: who is at risk for alcoholism. | Foroud T et al. | β | 2010 | β |
| Genome-wide association study of alcohol dependence implicates a region on chromosome 11. | Edenberg HJ et al. | β | 2010 | β |
| Person-environment interaction in the prediction of alcohol abuse and alcohol dependence in adulthood. | Hill KG et al. | β | 2010 | β |
| Pharmacogenetics of alcohol and alcohol dependence treatment. | Kranzler HR et al. | β | 2010 | β |
| Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. | Chen AC et al. | β | 2010 | β |
| The role of microRNAs in drug addiction: a big lesson from tiny molecules. | Pietrzykowski AZ | β | 2010 | β |
| Addiction genetics and pleiotropic effects of common haplotypes that make polygenic contributions to vulnerability to substance dependence. | Uhl GR et al. | β | 2009 | β |
| Altering the relative abundance of GABA A receptor subunits changes GABA- and ethanol-responses in Xenopus oocytes. | Hurley JH et al. | β | 2009 | β |
| Dopamine D4 receptor gene exon III polymorphism associated with binge drinking attitudinal phenotype. | Vaughn MG et al. | β | 2009 | β |
| Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors. | Corl AB et al. | β | 2009 | β |
| Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART). | Blum K et al. | β | 2009 | β |
| Severity of alcohol dependence in decompensated alcoholic liver disease: comparison with heavy drinkers without liver disease and relationship to family drinking history. | Gleeson D et al. | β | 2009 | β |
| The role of GABA(A) receptors in the acute and chronic effects of ethanol: a decade of progress. | Kumar S et al. | β | 2009 | β |
| Addiction Reviews. Preface. | Uhl GR | β | 2008 | β |
| Approach to the genetics of alcoholism: a review based on pathophysiology. | KΓΆhnke MD | β | 2008 | β |
| GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. | Soyka M et al. | β | 2008 | β |
| GABA(A) receptors and alcohol. | Lobo IA et al. | β | 2008 | β |
| Genomic imprinting and human psychology: cognition, behavior and pathology. | Goos LM et al. | β | 2008 | β |
| "Higher order" addiction molecular genetics: convergent data from genome-wide association in humans and mice. | Uhl GR et al. | β | 2008 | β |
| Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene. | Covault J et al. | β | 2008 | β |
| Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects. | Uhl GR et al. | β | 2008 | β |
| Multiple-domain predictors of problematic alcohol use in young adulthood. | Kramer JR et al. | β | 2008 | β |
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | Wetherill L et al. | β | 2008 | β |
| The genetics of alcohol and other drug dependence. | Dick DM et al. | β | 2008 | β |
| The role of GABA(A) receptors in the development of alcoholism. | Enoch MA | β | 2008 | β |
| Will we ever find the genes for addiction? | Buckland PR | β | 2008 | β |
| Alcohol: effects on neurobehavioral functions and the brain. | Oscar-Berman M et al. | β | 2007 | β |
| Association of alcohol craving with alpha-synuclein (SNCA). | Foroud T et al. | β | 2007 | β |
| Lack of association of alcohol dependence and habitual smoking with catechol-O-methyltransferase. | Foroud T et al. | β | 2007 | β |
| Association of the kappa-opioid system with alcohol dependence. | Xuei X et al. | β | 2006 | β |
| Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism. | Dick DM et al. | β | 2006 | β |
| Female offspring of alcoholic individuals: recent findings on alcoholism and psychopathology risks: symposium presented at the Research Society on Alcoholism, 2004, Vancouver Aruna Gogineni, Chair. | Gogineni A et al. | β | 2006 | β |
| GABA(A) receptor subtypes as targets for neuropsychiatric drug development. | Korpi ER et al. | β | 2006 | β |
| New findings on the genetic influences on alcohol use and dependence. | Higuchi S et al. | β | 2006 | β |
| New pharmacological approaches for the treatment of alcoholism. | Soyka M et al. | β | 2006 | β |
| The genetics of alcohol dependence. | Dick DM et al. | β | 2006 | β |
| The genetics of alcoholism: identifying specific genes through family studies. | Edenberg HJ et al. | β | 2006 | β |
| The next challenge for psychiatric genetics: characterizing the risk associated with identified genes. | Dick DM et al. | β | 2006 | β |
| The polymorphism GABABR1 T1974C[rs29230] of the GABAB receptor gene is not associated with the diagnosis of alcoholism or alcohol withdrawal seizures. | KΓΆhnke M et al. | β | 2006 | β |
| Alcohol and gene interactions. | Whitfield JB | β | 2005 | β |
| Description of the data from the Collaborative Study on the Genetics of Alcoholism (COGA) and single-nucleotide polymorphism genotyping for Genetic Analysis Workshop 14. | Edenberg HJ et al. | β | 2005 | β |
| Development of medications for alcohol use disorders: recent advances and ongoing challenges. | Litten RZ et al. | β | 2005 | β |
| Expression profiling and QTL analysis: a powerful complementary strategy in drug abuse research. | Spence J et al. | β | 2005 | β |
| Genetic time-series analysis identifies a major QTL for in vivo alcohol metabolism not predicted by in vitro studies of structural protein polymorphism at the ADH1B or ADH1C loci. | Birley AJ et al. | β | 2005 | β |
| No association of the GABAA receptor genes on chromosome 5 with alcoholism in the collaborative study on the genetics of alcoholism sample. | Dick DM et al. | β | 2005 | β |
| The contribution of genetics to addiction therapy approaches. | Edenberg HJ et al. | β | 2005 | β |
| The development of alcohol use disorders. | Sher KJ et al. | β | 2005 | β |
| Drug addiction: the neurobiology of behaviour gone awry. | Volkow ND et al. | β | 2004 | β |
| The search for genes contributing to the low level of response to alcohol: patterns of findings across studies. | Schuckit MA et al. | β | 2004 | β |