EEG phenotypes predict treatment outcome to stimulants in children with ADHD.
paper
Cited
Public
Unavailable
- Authors
- Arns, Martijn; Gunkelman, Jay; Breteler, Marinus; Spronk, Desirée
- Year
- 2008
- Journal
- Journal of integrative neuroscience
- PMID
- 18988300
- DOI
- 10.1142/s0219635208001897
This study demonstrates that the EEG phenotypes as described by Johnstone, Gunkelman & Lunt are identifiable EEG patterns with good inter-rater reliability. Furthermore, it was also demonstrated that these EEG phenotypes occurred in both ADHD subjects as well as healthy control subjects. The Frontal Slow and Slowed Alpha Peak Frequency and the Low Voltage EEG phenotype discriminated ADHD subjects best from controls (however the difference was not significant). The Frontal Slow group responded to a stimulant with a clinically relevant decreased number of false negative errors on the CPT. The Frontal Slow and Slowed Alpha Peak Frequency phenotypes have different etiologies as evidenced by the treatment response to stimulants. In previous research Slowed Alpha Peak Frequency has most likely erroneously shown up as a frontal theta sub-group. This implies that future research employing EEG measures in ADHD should avoid using traditional frequency bands, but dissociate Slowed Alpha Peak Frequency from frontal theta by taking the individual alpha peak frequency into account. Furthermore, the divergence from normal of the frequency bands pertaining to the various phenotypes is greater in the clinical group than in the controls. Investigating EEG phenotypes provides a promising new way to approach EEG data, explaining much of the variance in EEGs and thereby potentially leading to more specific prospective treatment outcomes.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Advances in Electrophysiological Research. | 2015 | 26259089 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Characterization of transient events during intermittent photic stimulation. | Oppermann H et al. | — | 2025 | → |
| Methylphenidate and P300 in attention deficit hyperactivity disorder: A systematic review and meta-analysis. | C R Barroso B et al. | — | 2025 | → |
| Peak Alpha Frequency Is Not Significantly Altered by Five Days of Experimental Pain and Repetitive Transcranial Stimulation of the Left Dorsolateral Prefrontal Cortex. | Millard SK et al. | — | 2025 | → |
| Theta/Beta Ratio Neurofeedback Effects on Resting and Task-Related Theta Activity in Children with ADHD. | Enriquez-Geppert S et al. | — | 2025 | → |
| Longitudinal Stability of Neural Correlates of Pediatric Attention Deficit Hyperactivity Disorder: A Pilot Study of Event Related Potentials and Electroencephalography. | Peisch V et al. | — | 2024 | → |
| Peak alpha frequency is not significantly altered by five days of experimental pain and repetitive transcranial stimulation of the left dorsolateral prefrontal cortex | Millard SK et al. | — | 2024 | — |
| Point of Care Testing (POCT) in Psychopathology Using Fractal Analysis and Hilbert Huang Transform of Electroencephalogram (EEG). | Khan MSI et al. | — | 2024 | → |
| The Importance of Low-frequency Alpha (8-10 Hz) Waves and Default Mode Network in Behavioral Inhibition. | Kim YW et al. | — | 2024 | → |
| Exploration of electroencephalogram response to MPH treatment in ADHD patients. | Takahara Y et al. | — | 2023 | → |
| Neural oscillation amplitude in the frontal cortex predicts esport results. | Minami S et al. | — | 2023 | → |
| Resting-state electroencephalography and magnetoencephalography as biomarkers of chronic pain: a systematic review. | Zebhauser PT et al. | — | 2023 | → |
| Isolated epileptiform activity in children and adolescents: prevalence, relevance, and implications for treatment. | Swatzyna RJ et al. | — | 2022 | → |
| Reduced Power in Fronto-Parietal Theta EEG Linked to Impaired Attention-Sampling in Adult ADHD. | Cowley BU et al. | — | 2022 | → |
| Stratified psychiatry: Tomorrow's precision psychiatry? | Arns M et al. | — | 2022 | → |
| Toward Precision Medicine in ADHD. | Buitelaar J et al. | — | 2022 | → |
| Treatment biomarkers for ADHD: Taking stock and moving forward. | Michelini G et al. | — | 2022 | → |
| What Has Been Learned from Using EEG Methods in Research of ADHD? | McLoughlin G et al. | — | 2022 | → |
| Individual Alpha Peak Frequency, an Important Biomarker for Live Z-Score Training Neurofeedback in Adolescents with Learning Disabilities. | Pérez-Elvira R et al. | — | 2021 | → |
| Individual alpha peak frequency is slower in schizophrenia and related to deficits in visual perception and cognition. | Ramsay IS et al. | — | 2021 | → |
| Precision Medicine Care in ADHD: The Case for Neural Excitation and Inhibition. | Mamiya PC et al. | — | 2021 | → |
| Quantitative EEG in Childhood Attention Deficit Hyperactivity Disorder and Learning Disabilities. | Chiarenza GA | — | 2021 | → |
| Quantitative Electroencephalogram Standardization: A Sex- and Age-Differentiated Normative Database. | Ko J et al. | — | 2021 | → |
| To spindle or not to spindle: A replication study into spindling excessive beta as a transdiagnostic EEG feature associated with impulse control. | Krepel N et al. | — | 2021 | → |
| Alleviation of ADHD symptoms by non-invasive right prefrontal stimulation is correlated with EEG activity. | Alyagon U et al. | — | 2020 | → |
| A multicenter effectiveness trial of QEEG-informed neurofeedback in ADHD: Replication and treatment prediction. | Krepel N et al. | — | 2020 | → |
| Excessive Daytime Sleepiness Measurements in Children With Attention Deficit Hyperactivity Disorder. | Bioulac S et al. | — | 2020 | → |
| Linking alpha oscillations, attention and inhibitory control in adult ADHD with EEG neurofeedback. | Deiber MP et al. | — | 2020 | → |
| Resting state EEG power research in Attention-Deficit/Hyperactivity Disorder: A review update. | Clarke AR et al. | — | 2020 | → |
| Vigilance, Inhibitory Control and Regional Cerebral Blood Oxygenation in the PFC - Differences in ADHD Types of Presentations. | Skalski S et al. | — | 2020 | → |
| EEG-vigilance regulation in Borderline Personality Disorder. | Kramer L et al. | — | 2019 | → |
| Measuring Treatment Response in Pharmacological and Lifestyle Interventions Using Electroencephalography in ADHD: A Review. | Kirkland AE et al. | — | 2019 | → |
| Normalization of EEG in depression after antidepressant treatment with sertraline? A preliminary report. | van der Vinne N et al. | — | 2019 | → |
| Predicting Clinical Gains and Side Effects of Stimulant Medication in Pediatric Attention-Deficit/Hyperactivity Disorder by Combining Measures From qEEG and ERPs in a Cued GO/NOGO Task. | Ogrim G et al. | — | 2019 | → |
| Probing the "Default Network Interference Hypothesis" With EEG: An RDoC Approach Focused on Attention. | Gerrits B et al. | — | 2019 | → |
| Stability of frontal alpha asymmetry in depressed patients during antidepressant treatment. | van der Vinne N et al. | — | 2019 | → |
| Abnormal Resting-State Quantitative Electroencephalogram in Children With Central Auditory Processing Disorder: A Pilot Study. | Milner R et al. | — | 2018 | → |
| Beyond Epilepsy: How Can Quantitative Electroencephalography Improve Conventional Electroencephalography Findings? A Systematic Review of Comparative EEG Studies. | Martins CHT et al. | — | 2018 | → |
| Electroencephalographic biomarkers as predictors of methylphenidate response in attention-deficit/hyperactivity disorder. | Arns M et al. | — | 2018 | → |
| Neuropsychological and Neurophysiological Indicators of General and Food-Specific Impulsivity in Children with Overweight and Obesity: A Pilot Study. | Schmidt R et al. | — | 2018 | → |
| Resting-State Neurophysiological Activity Patterns in Young People with ASD, ADHD, and ASD + ADHD. | Shephard E et al. | — | 2018 | → |
| Age-Related Changes in Resting-State EEG Activity in Attention Deficit/Hyperactivity Disorder: A Cross-Sectional Study. | Giertuga K et al. | — | 2017 | → |
| Closed-loop brain training: the science of neurofeedback. | Sitaram R et al. | — | 2017 | → |
| EEG Abnormalities Are Associated With Poorer Depressive Symptom Outcomes With Escitalopram and Venlafaxine-XR, but Not Sertraline: Results From the Multicenter Randomized iSPOT-D Study. | Arns M et al. | — | 2017 | → |
| Computer Enabled Neuroplasticity Treatment: A Clinical Trial of a Novel Design for Neurofeedback Therapy in Adult ADHD. | Cowley B et al. | — | 2016 | → |
| EEG alpha asymmetry as a gender-specific predictor of outcome to acute treatment with different antidepressant medications in the randomized iSPOT-D study. | Arns M et al. | — | 2016 | → |
| Epileptic Electroencephalography Profile Associates with Attention Problems in Children with Fragile X Syndrome: Review and Case Series. | Cowley B et al. | — | 2016 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Electroencephalographic activity before and after cognitive effort in children with attention deficit/hyperactivity disorder. | Buyck I et al. | — | 2015 | → |
| Frontal and rostral anterior cingulate (rACC) theta EEG in depression: implications for treatment outcome? | Arns M et al. | — | 2015 | → |
| How the Individual Alpha Peak Frequency Helps Unravel the Neurophysiologic Underpinnings of Behavioral Functioning in Children With Attention-Deficit/Hyperactivity Disorder. | Vollebregt MA et al. | — | 2015 | → |
| Neurofeedback as a nonpharmacological treatment for adults with attention-deficit/hyperactivity disorder (ADHD): study protocol for a randomized controlled trial. | Mayer K et al. | — | 2015 | → |
| Personalized Medicine: Review and Perspectives of Promising Baseline EEG Biomarkers in Major Depressive Disorder and Attention Deficit Hyperactivity Disorder. | Olbrich S et al. | — | 2015 | → |
| Age dependent electroencephalographic changes in attention-deficit/hyperactivity disorder (ADHD). | Poil SS et al. | — | 2014 | → |
| Association between COMT Val158Met genotype and EEG alpha peak frequency tested in two independent cohorts. | Veth CP et al. | — | 2014 | → |
| Can quantitative EEG measures predict clinical outcome in subjects at Clinical High Risk for psychosis? A prospective multicenter study. | van Tricht MJ et al. | — | 2014 | → |
| Evaluation of neurofeedback in ADHD: the long and winding road. | Arns M et al. | — | 2014 | → |
| Interpreting EEG alpha activity. | Bazanova OM et al. | — | 2014 | → |
| Neurofeedback in ADHD and insomnia: vigilance stabilization through sleep spindles and circadian networks. | Arns M et al. | — | 2014 | → |
| Neurophysiologic predictors of response to atomoxetine in young adults with attention deficit hyperactivity disorder: a pilot project. | Leuchter AF et al. | — | 2014 | → |
| P300 development across the lifespan: a systematic review and meta-analysis. | van Dinteren R et al. | — | 2014 | → |
| Personalized Medicine in ADHD and Depression: Use of Pharmaco-EEG. | Arns M et al. | — | 2014 | → |
| Predicting the clinical outcome of stimulant medication in pediatric attention-deficit/hyperactivity disorder: data from quantitative electroencephalography, event-related potentials, and a go/no-go test. | Ogrim G et al. | — | 2014 | → |
| Resting electroencephalogram in attention deficit hyperactivity disorder: developmental course and diagnostic value. | Buyck I et al. | — | 2014 | → |
| The effects of individual upper alpha neurofeedback in ADHD: an open-label pilot study. | Escolano C et al. | — | 2014 | → |
| Tuning pathological brain oscillations with neurofeedback: a systems neuroscience framework. | Ros T et al. | — | 2014 | → |
| What future research should bring to help resolving the debate about the efficacy of EEG-neurofeedback in children with ADHD. | Vollebregt MA et al. | — | 2014 | → |
| A decade of EEG Theta/Beta Ratio Research in ADHD: a meta-analysis. | Arns M et al. | — | 2013 | → |
| A proposed multisite double-blind randomized clinical trial of neurofeedback for ADHD: need, rationale, and strategy. | Kerson C et al. | — | 2013 | → |
| Clinical advantages of quantitative electroencephalogram (QEEG)-electrical neuroimaging application in general neurology practice. | Koberda JL et al. | — | 2013 | → |
| Predicting acute side effects of stimulant medication in pediatric attention deficit/hyperactivity disorder: data from quantitative electroencephalography, event-related potentials, and a continuous-performance test. | Ogrim G et al. | — | 2013 | → |
| A brain-computer interface based attention training program for treating attention deficit hyperactivity disorder. | Lim CG et al. | — | 2012 | → |
| Clinical utility of EEG in attention-deficit/hyperactivity disorder: a research update. | Loo SK et al. | — | 2012 | → |
| Neurophysiological predictors of non-response to rTMS in depression. | Arns M et al. | — | 2012 | → |
| Nonlinear dynamics measures applied to EEG recordings of patients with attention deficit/hyperactivity disorder: quantifying the effects of a neurofeedback treatment. | Cerquera A et al. | — | 2012 | → |
| The effects of QEEG-informed neurofeedback in ADHD: an open-label pilot study. | Arns M et al. | — | 2012 | → |
| The quantitative EEG theta/beta ratio in attention deficit/hyperactivity disorder and normal controls: sensitivity, specificity, and behavioral correlates. | Ogrim G et al. | — | 2012 | → |
| ADHD and EEG-neurofeedback: a double-blind randomized placebo-controlled feasibility study. | Lansbergen MM et al. | — | 2011 | → |
| The increase in theta/beta ratio on resting-state EEG in boys with attention-deficit/hyperactivity disorder is mediated by slow alpha peak frequency. | Lansbergen MM et al. | — | 2011 | → |
| EEG-vigilance and response to stimulants in paediatric patients with attention deficit/hyperactivity disorder. | Sander C et al. | — | 2010 | → |
| Identifying phronotypes in psychiatry. | Kozel FA | — | 2010 | → |
| Efficacy of neurofeedback treatment in ADHD: the effects on inattention, impulsivity and hyperactivity: a meta-analysis. | Arns M et al. | — | 2009 | → |
| Resting state electroencephalographic correlates with red cell long-chain fatty acids, memory performance and age in adolescent boys with attention deficit hyperactivity disorder. | Sumich A et al. | — | 2009 | → |