Decreased cocaine self-administration in Kir3 potassium channel subunit knockout mice.
paper
Cited
Public
Unavailable
- Authors
- Morgan, Andrew D; Carroll, Marilyn E; Loth, Annemarie K; Stoffel, Markus; Wickman, Kevin
- Year
- 2003
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 12637950
- DOI
- 10.1038/sj.npp.1300100
Multiple G protein-linked neurotransmitter systems have been implicated in the behavioral effects of cocaine. While actions of certain neurotransmitter receptor subtypes and transporters have been identified, the role of individual G protein-regulated enzymes and ion channels in the effects of cocaine remains unclear. Here, we assessed the contribution of G protein-gated, inwardly rectifying potassium (Kir3/GIRK) channels to the locomotor-stimulatory and reinforcing effects of cocaine using knockout mice lacking one or both of the key neuronal channel subunits, Kir3.2 and Kir3.3. Cocaine-stimulated increases in horizontal locomotor activity in wild-type, Kir3.2 knockout, Kir3.3 knockout, and Kir3.2/3.3 double knockout mice, with only minor differences observed between the mouse lines. In contrast, Kir3.2 and Kir3.3 knockout mice exhibited dramatically reduced intravenous self-administration of cocaine relative to wild-type mice over a range of cocaine doses. Paradoxically, Kir3.2/3.3 double knockout mice self-administered cocaine at levels significantly higher than either single knockout alone. These findings suggest that Kir3 channels play significant and complex roles in the reinforcing effect of cocaine.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| G protein-gated inwardly rectifying K<sup>+</sup> (GIRK/K<sub>ir</sub>3) channels: Molecular, cellular, and subcellular diversity. | MartΓn-Belmonte A et al. | β | 2025 | β |
| Direct modulation of G protein-gated inwardly rectifying potassium (GIRK) channels. | Nguyen H et al. | β | 2024 | β |
| GIRK Channels as Candidate Targets for the Treatment of Substance Use Disorders. | Kotajima-Murakami H et al. | β | 2022 | β |
| Neuronal G protein-gated K<sup>+</sup> channels. | Luo H et al. | β | 2022 | β |
| The Relevance of GIRK Channels in Heart Function. | Campos-RΓos A et al. | β | 2022 | β |
| Cocaine induces paradigm-specific changes to the transcriptome within the ventral tegmental area. | Campbell RR et al. | β | 2021 | β |
| Identification of Molecular Markers of Clozapine Action in Ketamine-Induced Cognitive Impairment: A GPCR Signaling PathwayFinder Study. | Korlatowicz A et al. | β | 2021 | β |
| Kir Channel Molecular Physiology, Pharmacology, and Therapeutic Implications. | Cui M et al. | β | 2021 | β |
| Potassium Channels and Their Potential Roles in Substance Use Disorders. | McCoy MT et al. | β | 2021 | β |
| Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system. | Jeremic D et al. | β | 2021 | β |
| Absence of methamphetamine-induced conditioned place preference in weaver mutant mice. | Ikekubo Y et al. | β | 2020 | β |
| A Single Prior Injection of Methamphetamine Enhances Methamphetamine Self-Administration (SA) and Blocks SA-Induced Changes in DNA Methylation and mRNA Expression of Potassium Channels in the Rat Nucleus Accumbens. | Jayanthi S et al. | β | 2020 | β |
| Identification of a G-Protein-Independent Activator of GIRK Channels. | Zhao Y et al. | β | 2020 | β |
| KCNJ6 variants modulate reward-related brain processes and impact executive functions in attention-deficit/hyperactivity disorder. | Ziegler GC et al. | β | 2020 | β |
| GIRK Channel Activity in Dopamine Neurons of the Ventral Tegmental Area Bidirectionally Regulates Behavioral Sensitivity to Cocaine. | McCall NM et al. | β | 2019 | β |
| Study of effects of ifenprodil in patients with methamphetamine dependence: Protocol for an exploratory, randomized, double-blind, placebo-controlled trial. | Kotajima-Murakami H et al. | β | 2019 | β |
| A KCNJ6 gene polymorphism modulates theta oscillations during reward processing. | Kamarajan C et al. | β | 2017 | β |
| G Protein-Gated Potassium Channels: A Link to Drug Addiction. | Rifkin RA et al. | β | 2017 | β |
| Selective Ablation of GIRK Channels in Dopamine Neurons Alters Behavioral Effects of Cocaine in Mice. | McCall NM et al. | β | 2017 | β |
| A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine Neurons. | Munoz MB et al. | β | 2016 | β |
| Methamphetamine addiction: involvement of CREB and neuroinflammatory signaling pathways. | Krasnova IN et al. | β | 2016 | β |
| A systems approach identifies networks and genes linking sleep and stress: implications for neuropsychiatric disorders. | Jiang P et al. | β | 2015 | β |
| Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction. | Mayfield J et al. | β | 2015 | β |
| GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol. | Herman MA et al. | β | 2015 | β |
| GIRK Channel Plasticity and Implications for Drug Addiction. | Marron Fernandez de Velasco E et al. | β | 2015 | β |
| GIRK Channels: A Potential Link Between Learning and Addiction. | Tipps ME et al. | β | 2015 | β |
| Localization and Targeting of GIRK Channels in Mammalian Central Neurons. | LujΓ‘n R et al. | β | 2015 | β |
| Tipepidine increases dopamine level in the nucleus accumbens without methamphetamine-like behavioral sensitization. | Hamao K et al. | β | 2015 | β |
| Alcohol modulation of G-protein-gated inwardly rectifying potassium channels: from binding to therapeutics. | Bodhinathan K et al. | β | 2014 | β |
| Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and post-operative analgesia, pain sensitivity, and nicotine dependence. | Nishizawa D et al. | β | 2014 | β |
| New insights into the therapeutic potential of Girk channels. | LujΓ‘n R et al. | β | 2014 | β |
| Sorting nexin 27 regulation of G protein-gated inwardly rectifying KβΊ channels attenuates in vivo cocaine response. | Munoz MB et al. | β | 2014 | β |
| Male mice that lack the G-protein-coupled receptor GPR41 have low energy expenditure and increased body fat content. | Bellahcene M et al. | β | 2013 | β |
| Role of GIRK channels on the noradrenergic transmission in vivo: an electrophysiological and neurochemical study on GIRK2 mutant mice. | Torrecilla M et al. | β | 2013 | β |
| Eag1, Eag2, and SK3 potassium channel expression in the rat hippocampus after global transient brain ischemia. | de Oliveira RM et al. | β | 2012 | β |
| Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. | Padgett CL et al. | β | 2012 | β |
| RGS proteins maintain robustness of GPCR-GIRK coupling by selective stimulation of the G protein subunit GΞ±o. | Chuang HH et al. | β | 2012 | β |
| Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice. | Cooper A et al. | β | 2012 | β |
| Identification of selective agonists and antagonists to g protein-activated inwardly rectifying potassium channels: candidate medicines for drug dependence and pain. | Nishizawa D et al. | β | 2011 | β |
| Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants. | Kobayashi T et al. | β | 2011 | β |
| The Selective Serotonin Reuptake Inhibitor Paroxetine, but not Fluvoxamine, Decreases Methamphetamine Conditioned Place Preference in Mice. | Takamatsu Y et al. | β | 2011 | β |
| Altered neurotransmission in the mesolimbic reward system of Girk mice. | Arora D et al. | β | 2010 | β |
| Eag 1, Eag 2 and Kcnn3 gene brain expression of isolated reared rats. | Martin S et al. | β | 2010 | β |
| Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. | LΓΌscher C et al. | β | 2010 | β |
| Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective norepinephrine reuptake inhibitors atomoxetine and reboxetine. | Kobayashi T et al. | β | 2010 | β |
| Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities. | Bhave G et al. | β | 2010 | β |
| The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels. | Zylbergold P et al. | β | 2010 | β |
| CRF enhancement of GIRK channel-mediated transmission in dopamine neurons. | Beckstead MJ et al. | β | 2009 | β |
| Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels. | Kobayashi T et al. | β | 2009 | β |
| Mouse model of relapse to the abuse of drugs: procedural considerations and characterizations. | Yan Y et al. | β | 2009 | β |
| Alterations in fos-related antigen 2 and sigma1 receptor gene and protein expression are associated with the development of cocaine-induced behavioral sensitization: time course and regional distribution studies. | Liu Y et al. | β | 2008 | β |
| Behavioral characterization of mice lacking GIRK/Kir3 channel subunits. | Pravetoni M et al. | β | 2008 | β |
| Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain. | Saenz del Burgo L et al. | β | 2008 | β |
| Pre- and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: a study of GIRK-knockout mice. | Torrecilla M et al. | β | 2008 | β |
| Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels. | Clancy SM et al. | β | 2007 | β |
| Heterogeneous distribution of kir3 potassium channel proteins within dopaminergic neurons in the mesencephalon of the rat brain. | Eulitz D et al. | β | 2007 | β |
| Fluoxetine as a potential pharmacotherapy for methamphetamine dependence: studies in mice. | Takamatsu Y et al. | β | 2006 | β |
| Gene expression profiling in the striatum of inbred mouse strains with distinct opioid-related phenotypes. | Korostynski M et al. | β | 2006 | β |
| G protein-activated inwardly rectifying K+ channel inhibition and rescue of weaver mouse motor functions by antidepressants. | Takahashi T et al. | β | 2006 | β |
| Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil. | Kobayashi T et al. | β | 2006 | β |
| Relapse of methamphetamine-seeking behavior in C57BL/6J mice demonstrated by a reinstatement procedure involving intravenous self-administration. | Yan Y et al. | β | 2006 | β |
| Complex genetics of interactions of alcohol and CNS function and behavior. | Matthews DB et al. | β | 2005 | β |
| Ion channels and intracellular signaling proteins as potential targets for novel therapeutics for addictive and depressive disorders. | Bonci A et al. | β | 2005 | β |
| Molecular and cellular diversity of neuronal G-protein-gated potassium channels. | Koyrakh L et al. | β | 2005 | β |
| Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking. | Bowers MS et al. | β | 2004 | β |
| Inhibition of G protein-activated inwardly rectifying K+ channels by various antidepressant drugs. | Kobayashi T et al. | β | 2004 | β |
| Modulators of G protein-activated inwardly rectifying K+ channels: potentially therapeutic agents for addictive drug users. | Kobayashi T et al. | β | 2004 | β |
| Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia. | Marker CL et al. | β | 2004 | β |
| Stimulant and reinforcing effects of cocaine in monoamine transporter knockout mice. | Rocha BA | β | 2003 | β |