Association analysis of polymorphisms in serotonin 1B receptor (HTR1B) gene with heroin addiction: a comparison of molecular and statistically estimated haplotypes.
- Authors
- Proudnikov, Dmitri; LaForge, K Steven; Hofflich, Heather; Levenstien, Mark; Gordon, Derek; Barral, Sandra; Ott, Jurg; Kreek, Mary Jeanne
- Year
- 2006
- Journal
- Pharmacogenetics and genomics
- PMID
- 16344719
- DOI
- 10.1097/01.fpc.0000182782.87932.d6
OBJECTIVES: 5-Hydroxytryptamine (serotonin)-1B receptors (HTR1B) may play an important role in psychiatric disorders and drug and alcohol dependence. In this study we report on genotype, molecular haplotype and statistically estimated haplotype analyses of previously identified polymorphisms in positions -261T>G, -161A>T, 129C>T, 861G>C and 1180A>G of the HTR1B gene in ethnically diverse populations (African-Americans, Caucasians, Hispanics and Asians) including 235 former heroin addicts and 161 control subjects from New York City. The objectives were to test for an association of molecular and statistically estimated haplotypes and genotypes in HTR1B gene with heroin addiction and to compare results provided by molecular and statistically estimated haplotyping methods. METHODS: Genotype analysis was performed using a standard TaqMan protocol. Molecular haplotype analysis of the subset of polymorphisms consisting of -261T>G, -161A>T and 129C>T was performed using a protocol specially designed by our group, using fluorescent PCR. This is based on use of allele-specific primers complementary to flanking polymorphisms and a fluorescently labeled sequence-specific TaqMan probe set complementary to an internal polymorphism of the haplotype region. Every individual's statistically inferred haplotype pair agreed with the individual's haplotype pair determined by molecular haplotyping. RESULTS AND CONCLUSION: A point-wise significant association of haplotype pairs containing allele G at position 1180 with protective effect from heroin addiction in Caucasians was found. A point-wise nominally significant association of allele 1180G with a protective effect from heroin addiction was found in Caucasians. Statistically significant differences across four ethnic groups in control subjects for allelic frequencies of -261T>G and -161A>T were found.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Opioid use and abuse in adolescents and young adults; dealing with science, laws and ethics: Charming the COBRAS. | Greydanus DE et al. | — | 2025 | → |
| An update: epigenetic mechanisms underlying methamphetamine addiction. | Liu M et al. | — | 2024 | → |
| Serotonin 1B receptor effects on response inhibition are independent of inhibitory learning. | Desrochers SS et al. | — | 2022 | → |
| The distinct roles of various neurotransmitters in modulating methamphetamine-induced conditioned place preference in relevant brain regions in mice. | Su H et al. | — | 2022 | → |
| The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers. | Mateu C et al. | — | 2021 | → |
| VMAT2 gene (<i>SLC18A2</i>) variants associated with a greater risk for developing opioid dependence. | Randesi M et al. | — | 2019 | → |
| Serotonin receptors in depression: from A to B | Nautiyal KM et al. | — | 2017 | — |
| Serotonin receptors in depression: from A to B. | Nautiyal KM et al. | — | 2017 | → |
| Regulation of nucleus accumbens transcript levels in mice by early-life social stress and cocaine. | Lo Iacono L et al. | — | 2016 | → |
| Distinct Circuits Underlie the Effects of 5-HT1B Receptors on Aggression and Impulsivity. | Nautiyal KM et al. | — | 2015 | → |
| Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry. | Levran O et al. | — | 2015 | → |
| The role of serotonin in drug use and addiction. | Müller CP et al. | — | 2015 | → |
| Dopamine D3 and 5-HT1B receptor dysregulation as a result of psychostimulant intake and forced abstinence: Implications for medications development. | Neisewander JL et al. | — | 2014 | → |
| Genetics of opiate addiction. | Reed B et al. | — | 2014 | → |
| Pharmacological evidence for an abstinence-induced switch in 5-HT1B receptor modulation of cocaine self-administration and cocaine-seeking behavior. | Pentkowski NS et al. | — | 2014 | → |
| Reductions in brain 5-HT1B receptor availability in primarily cocaine-dependent humans. | Matuskey D et al. | — | 2014 | → |
| Associations of the 5-hydroxytryptamine (serotonin) receptor 1B gene (HTR1B) with alcohol, cocaine, and heroin abuse. | Cao J et al. | — | 2013 | → |
| NCK2 is significantly associated with opiates addiction in African-origin men. | Liu Z et al. | — | 2013 | → |
| Shared and unique genetic contributions to attention deficit/hyperactivity disorder and substance use disorders: a pilot study of six candidate genes. | Carpentier PJ et al. | — | 2013 | → |
| A haplotype analysis is consistent with the role of functional HTR1B variants in alcohol dependence. | Contini V et al. | — | 2012 | → |
| Availability of dopamine and serotonin transporters in opioid-dependent users--a two-isotope SPECT study. | Yeh TL et al. | — | 2012 | → |
| Common and specific liability to addiction: approaches to association studies of opioid addiction. | Nielsen DA et al. | — | 2012 | → |
| Genome-wide association study of comorbid depressive syndrome and alcohol dependence. | Edwards AC et al. | — | 2012 | → |
| Protracted withdrawal from cocaine self-administration flips the switch on 5-HT(1B) receptor modulation of cocaine abuse-related behaviors. | Pentkowski NS et al. | — | 2012 | → |
| Association Between 5HT1b Receptor Gene and Methamphetamine Dependence. | Ujike H et al. | — | 2011 | → |
| Genetic variability of pain perception and treatment--clinical pharmacological implications. | Lötsch J | — | 2011 | → |
| Polymorphism G861C of 5-HT receptor subtype 1B is associated with heroin dependence in Han Chinese. | Gao F et al. | — | 2011 | → |
| Functional polymorphisms in the serotonin 1B receptor gene (HTR1B) predict self-reported anger and hostility among young men. | Conner TS et al. | — | 2010 | → |
| Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. | Yuferov V et al. | — | 2010 | → |
| A common polymorphism in serotonin receptor 1B mRNA moderates regulation by miR-96 and associates with aggressive human behaviors. | Jensen KP et al. | — | 2009 | → |
| Bidirectional translational research: Progress in understanding addictive diseases. | Kreek MJ et al. | — | 2009 | → |
| Heroin addiction in African Americans: a hypothesis-driven association study. | Levran O et al. | — | 2009 | → |
| Opiate and cocaine addiction: from bench to clinic and back to the bench. | Kreek MJ et al. | — | 2009 | → |
| Pairing mild stress with increased serotonin-1B receptor expression in the nucleus accumbens increases susceptibility to amphetamine. | Ferguson SM et al. | — | 2009 | → |
| Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction. | Proudnikov D et al. | — | 2008 | → |
| Genotype patterns that contribute to increased risk for or protection from developing heroin addiction. | Nielsen DA et al. | — | 2008 | → |
| TPH2 and TPH1: association of variants and interactions with heroin addiction. | Nielsen DA et al. | — | 2008 | → |
| Homovanillic acid (HVA) plasma levels inversely correlate with attention deficit-hyperactivity and childhood neglect measures in addicted patients. | Gerra G et al. | — | 2007 | → |
| Quantifying bias due to allele misclassification in case-control studies of haplotypes. | Govindarajulu US et al. | — | 2006 | → |