Role of ERK in cocaine addiction.
paper
Cited
Public
Unavailable
- Authors
- Lu, Lin; Koya, Eisuke; Zhai, Haifeng; Hope, Bruce T; Shaham, Yavin
- Year
- 2006
- Journal
- Trends in neurosciences
- PMID
- 17084911
- DOI
- 10.1016/j.tins.2006.10.005
Cocaine addiction is characterized by compulsive drug-taking behavior and high rates of relapse. According to recent theories, this addiction is due to drug-induced adaptations in the cellular mechanisms that underlie normal learning and memory. Such mechanisms involve signaling by extracellular signal-regulated kinase (ERK). As we review here, evidence from rodent studies also implicates ERK in cocaine psychomotor sensitization, cocaine reward, consolidation and reconsolidation of memories for cocaine cues, and time-dependent increases in cocaine seeking after withdrawal (incubation of cocaine craving). The role of ERK in these behaviors involves long-term stable alterations in synaptic plasticity that result from repeated cocaine exposure, and also rapidly induced alterations in synaptic transmission events that acutely control cocaine-seeking behaviors. Pharmacological manipulations that decrease the extent to which cocaine and cocaine cues induce ERK activity might therefore be considered as potential treatments for cocaine addiction.
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