MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
paper
Cited
Public
Unavailable
- Authors
- Wu, L; Aster, J C; Blacklow, S C; Lake, R; Artavanis-Tsakonas, S; Griffin, J D
- Year
- 2000
- Journal
- Nature genetics
- PMID
- 11101851
- DOI
- 10.1038/82644
Notch receptors are involved in cell-fate determination in organisms as diverse as flies, frogs and humans. In Drosophila melanogaster , loss-of-function mutations of Notch produce a 'neurogenic' phenotype in which cells destined to become epidermis switch fate and differentiate to neural cells. Upon ligand activation, the intracellular domain of Notch (ICN) translocates to the nucleus, and interacts directly with the DNA-binding protein Suppressor of hairless (Su(H)) in flies, or recombination signal binding protein Jkappa (RBP-Jkappa) in mammals, to activate gene transcription. But the precise mechanisms of Notch-induced gene expression are not completely understood. The gene mastermind has been identified in multiple genetic screens for modifiers of Notch mutations in Drosophila. Here we clone MAML1, a human homologue of the Drosophila gene Mastermind, and show that it encodes a protein of 130 kD localizing to nuclear bodies. MAML1 binds to the ankyrin repeat domain of all four mammalian NOTCH receptors, forms a DNA-binding complex with ICN and RBP-Jkappa, and amplifies NOTCH-induced transcription of HES1. These studies provide a molecular mechanism to explain the genetic links between mastermind and Notch in Drosophila and indicate that MAML1 functions as a transcriptional co-activator for NOTCH signalling.
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External
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| Notch signaling pathway and human placenta. | Zhao WX et al. | β | 2012 | β |
| Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts. | Ito R et al. | β | 2012 | β |
| Role of adrenomedullin in the growth and differentiation of stem and progenitor cells. | Larrayoz IM et al. | β | 2012 | β |
| The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification. | Italiano A et al. | β | 2012 | β |
| Tumor stem cells: A new approach for tumor therapy (Review). | Meng M et al. | β | 2012 | β |
| Assembly of a Notch transcriptional activation complex requires multimerization. | Vasquez-Del Carpio R et al. | β | 2011 | β |
| Ataxin-1 and Brother of ataxin-1 are components of the Notch signalling pathway. | Tong X et al. | β | 2011 | β |
| Breast cancer subtypes: two decades of journey from cell culture to patients. | Zhao X et al. | β | 2011 | β |
| Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia. | Liu H et al. | β | 2011 | β |
| High-level expression of Mastermind-like 2 contributes to aberrant activation of the NOTCH signaling pathway in human lymphomas. | KΓΆchert K et al. | β | 2011 | β |
| Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo. | Oyama T et al. | β | 2011 | β |
| Mastermind mutations generate a unique constellation of midline cells within the Drosophila CNS. | Zhang Y et al. | β | 2011 | β |
| MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development. | Jin G et al. | β | 2011 | β |
| NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications. | Clementz AG et al. | β | 2011 | β |
| NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of rapamycin (mTOR) signaling in T-cell development and T-cell acute lymphoblastic leukemia. | Guo D et al. | β | 2011 | β |
| Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. | Nie L et al. | β | 2011 | β |
| Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis. | Chapman G et al. | β | 2011 | β |
| Notch pathway inhibition significantly reduces rhabdomyosarcoma invasiveness and mobility in vitro. | Roma J et al. | β | 2011 | β |
| Notch regulation of tumor angiogenesis. | Bridges E et al. | β | 2011 | β |
| Notch signaling and Notch signaling modifiers. | Wang MM | β | 2011 | β |
| Notch Signaling in T-Cell Development and T-ALL. | Li X et al. | β | 2011 | β |
| Notch signalling in cancer progression and bone metastasis. | Sethi N et al. | β | 2011 | β |
| Probing the druggability of protein-protein interactions: targeting the Notch1 receptor ankyrin domain using a fragment-based approach. | Abdel-Rahman N et al. | β | 2011 | β |
| RBP-J promotes the maturation of neuronal progenitors. | Komine O et al. | β | 2011 | β |
| RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. | Wacker SA et al. | β | 2011 | β |
| Self-renewal related signaling in myeloid leukemia stem cells. | Heidel FH et al. | β | 2011 | β |
| The Notch signaling pathway: molecular basis of cell context dependency. | Schwanbeck R et al. | β | 2011 | β |
| The repression of Notch signaling occurs via the destabilization of mastermind-like 1 by Mesp2 and is essential for somitogenesis. | Sasaki N et al. | β | 2011 | β |
| Trp53 regulates Notch 4 signaling through Mdm2. | Sun Y et al. | β | 2011 | β |
| Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1. | Popko-Scibor AE et al. | β | 2011 | β |
| UVRAG is required for organ rotation by regulating Notch endocytosis in Drosophila. | Lee G et al. | β | 2011 | β |
| Ξ³-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease. | Nakayama K et al. | β | 2011 | β |
| Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. | Aste-AmΓ©zaga M et al. | β | 2010 | β |
| Distinct roles for cell-autonomous Notch signaling in cardiomyocytes of the embryonic and adult heart. | Kratsios P et al. | β | 2010 | β |
| Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. | Chen J et al. | β | 2010 | β |
| Inhibition of notch signaling blocks growth of glioblastoma cell lines and tumor neurospheres. | Chen J et al. | β | 2010 | β |
| Linking model systems to cancer therapeutics: the case of Mastermind. | Yedvobnick B et al. | β | 2010 | β |
| Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. | Ma J et al. | β | 2010 | β |
| Mechanistic insights into Notch receptor signaling from structural and biochemical studies. | Kovall RA et al. | β | 2010 | β |
| Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex. | Ishitani T et al. | β | 2010 | β |
| Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. | Del Bianco C et al. | β | 2010 | β |
| Notch and the skeleton. | Zanotti S et al. | β | 2010 | β |
| Notch as a molecular switch in neural stem cells. | Zhou ZD et al. | β | 2010 | β |
| Notch: Implications of endogenous inhibitors for therapy. | Dikic I et al. | β | 2010 | β |
| Notch regulation of early thymocyte development. | Yashiro-Ohtani Y et al. | β | 2010 | β |
| Notch signaling and the bone marrow hematopoietic stem cell niche. | Weber JM et al. | β | 2010 | β |
| Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia. | Pancewicz J et al. | β | 2010 | β |
| Notch signaling maintains proliferation and survival of the HL60 human promyelocytic leukemia cell line and promotes the phosphorylation of the Rb protein. | Li GH et al. | β | 2010 | β |
| Notch target gene deregulation and maintenance of the leukemogenic phenotype do not require RBP-J kappa in Ikaros null mice. | Chari S et al. | β | 2010 | β |
| Role of glycans and glycosyltransferases in the regulation of Notch signaling. | Jafar-Nejad H et al. | β | 2010 | β |
| Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. | Arnett KL et al. | β | 2010 | β |
| SUMO modification regulates the transcriptional activity of MAML1. | Lindberg MJ et al. | β | 2010 | β |
| The mastermind-like 1 (MAML1) co-activator regulates constitutive NF-kappaB signaling and cell survival. | Jin B et al. | β | 2010 | β |
| ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression. | Masserdotti G et al. | β | 2010 | β |
| A link between the expression of the stem cell marker HMGA2, grading, and the fusion CRTC1-MAML2 in mucoepidermoid carcinoma. | Fehr A et al. | β | 2009 | β |
| Crosstalk of Notch with p53 and p63 in cancer growth control. | Dotto GP | β | 2009 | β |
| Direct inhibition of the NOTCH transcription factor complex. | Moellering RE et al. | β | 2009 | β |
| GSK3beta is a negative regulator of the transcriptional coactivator MAML1. | Saint Just Ribeiro M et al. | β | 2009 | β |
| Mucoepidermoid carcinoma of the cervix: another tumor with the t(11;19)-associated CRTC1-MAML2 gene fusion. | Lennerz JK et al. | β | 2009 | β |
| Notch activation induces Akt signaling via an autocrine loop to prevent apoptosis in breast epithelial cells. | Meurette O et al. | β | 2009 | β |
| Notch signaling in cardiac development and disease. | de la Pompa JL | β | 2009 | β |
| Notch signaling in the hematopoietic system. | Sandy AR et al. | β | 2009 | β |
| Notch signaling: the core pathway and its posttranslational regulation. | Fortini ME | β | 2009 | β |
| Prognostic significance of p27Kip1, Ki-67, and CRTC1-MAML2 fusion transcript in mucoepidermoid carcinoma: a molecular and clinicopathologic study of 101 cases. | Miyabe S et al. | β | 2009 | β |
| The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity. | Hansson ML et al. | β | 2009 | β |
| A new type of MAML2 fusion in mucoepidermoid carcinoma. | Fehr A et al. | β | 2008 | β |
| Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. | Maillard I et al. | β | 2008 | β |
| Ectopic notch activation in developing podocytes causes glomerulosclerosis. | Waters AM et al. | β | 2008 | β |
| ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes. | Salat D et al. | β | 2008 | β |
| Functional role of Notch signaling in the developing and postnatal heart. | Nemir M et al. | β | 2008 | β |
| Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea. | Hayashi T et al. | β | 2008 | β |
| Ikaros regulates Notch target gene expression in developing thymocytes. | Chari S et al. | β | 2008 | β |
| It's T-ALL about Notch. | Demarest RM et al. | β | 2008 | β |
| Mastermind-like domain-containing 1 (MAMLD1 or CXorf6) transactivates the Hes3 promoter, augments testosterone production, and contains the SF1 target sequence. | Fukami M et al. | β | 2008 | β |
| Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways. | McElhinny AS et al. | β | 2008 | β |
| Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. | Li K et al. | β | 2008 | β |
| Molecular separation of two signaling pathways for the receptor, Notch. | Le Gall M et al. | β | 2008 | β |
| More complicated than it looks: assembly of Notch pathway transcription complexes. | Kovall RA | β | 2008 | β |
| Mutational and energetic studies of Notch 1 transcription complexes. | Del Bianco C et al. | β | 2008 | β |
| Notch and vascular smooth muscle cell phenotype. | Morrow D et al. | β | 2008 | β |
| Notch inhibits expression of the KrΓΌppel-like factor 4 tumor suppressor in the intestinal epithelium. | Ghaleb AM et al. | β | 2008 | β |
| Notch, neural stem cells, and brain tumors. | Pierfelice TJ et al. | β | 2008 | β |
| Notch signaling and diseases: an evolutionary journey from a simple beginning to complex outcomes. | Talora C et al. | β | 2008 | β |
| Notch signaling in leukemia. | Aster JC et al. | β | 2008 | β |
| Notch signaling: its role in epidermal homeostasis and in the pathogenesis of skin diseases. | Okuyama R et al. | β | 2008 | β |
| Notch tumor suppressor function. | Dotto GP | β | 2008 | β |
| Oncogenic NOTCH1 control of MYC and PI3K: challenges and opportunities for anti-NOTCH1 therapy in T-cell acute lymphoblastic leukemias and lymphomas. | Palomero T et al. | β | 2008 | β |
| RAM-induced allostery facilitates assembly of a notch pathway active transcription complex. | Friedmann DR et al. | β | 2008 | β |
| The FoxO3a gene is a key negative target of canonical Notch signalling in the keratinocyte UVB response. | Mandinova A et al. | β | 2008 | β |
| The molecular logic of Notch signaling--a structural and biochemical perspective. | Gordon WR et al. | β | 2008 | β |
| TPO-independent megakaryocytopoiesis. | Zheng C et al. | β | 2008 | β |
| A proline repeat domain in the Notch co-activator MAML1 is important for the p300-mediated acetylation of MAML1. | Saint Just Ribeiro M et al. | β | 2007 | β |
| Contribution of Notch signaling activation to human glioblastoma multiforme. | Kanamori M et al. | β | 2007 | β |
| Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. | Nam Y et al. | β | 2007 | β |
| CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior. | Tirado Y et al. | β | 2007 | β |
| Early regionalization of the otic placode and its regulation by the Notch signaling pathway. | AbellΓ³ G et al. | β | 2007 | β |
| Ex vivo expansion of umbilical cord blood stem cells for transplantation: growing knowledge from the hematopoietic niche. | Hofmeister CC et al. | β | 2007 | β |
| Generation of pro-T cells in vitro: potential for immune reconstitution. | Awong G et al. | β | 2007 | β |
| Gene-specific targeting of the histone chaperone asf1 to mediate silencing. | Goodfellow H et al. | β | 2007 | β |
| Investigating the genetic circuitry of mastermind in Drosophila, a notch signal effector. | Kankel MW et al. | β | 2007 | β |
| Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo. | Oyama T et al. | β | 2007 | β |
| Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. | Lefort K et al. | β | 2007 | β |
| Notch3 and the Notch3-upregulated RNA-binding protein HuD regulate Ikaros alternative splicing. | Bellavia D et al. | β | 2007 | β |
| Notch directly regulates Gata3 expression during T helper 2 cell differentiation. | Fang TC et al. | β | 2007 | β |
| Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-kappaB signaling. | Curry CL et al. | β | 2007 | β |
| Notch signaling in development and cancer. | BolΓ³s V et al. | β | 2007 | β |
| Notch signaling induces apoptosis in primary human CD34+ hematopoietic progenitor cells. | Chadwick N et al. | β | 2007 | β |
| The many faces of Notch signaling in skin-derived cells. | Pinnix CC et al. | β | 2007 | β |
| The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons. | Hooper C et al. | β | 2007 | β |
| The notch regulator MAML1 interacts with p53 and functions as a coactivator. | Zhao Y et al. | β | 2007 | β |
| The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development. | Wu L et al. | β | 2007 | β |
| Zebrafish Mib and Mib2 are mutual E3 ubiquitin ligases with common and specific delta substrates. | Zhang C et al. | β | 2007 | β |
| c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. | Weng AP et al. | β | 2006 | β |
| Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. | Nguyen BC et al. | β | 2006 | β |
| DNER as key molecule for cerebellar maturation. | Saito SY et al. | β | 2006 | β |
| Emerging biology of malignant salivary gland tumors offers new insights into the classification and treatment of mucoepidermoid cancer. | Kaye FJ | β | 2006 | β |
| Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells. | Duan L et al. | β | 2006 | β |
| HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding. | Yu X et al. | β | 2006 | β |
| Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. | Chiang MY et al. | β | 2006 | β |
| Impaired notch signaling promotes de novo squamous cell carcinoma formation. | Proweller A et al. | β | 2006 | β |
| Kaposi's Sarcoma-associated herpesvirus lytic switch protein stimulates DNA binding of RBP-Jk/CSL to activate the Notch pathway. | Carroll KD et al. | β | 2006 | β |
| Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. | Malecki MJ et al. | β | 2006 | β |
| MECT1-MAML2 fusion transcript defines a favorable subset of mucoepidermoid carcinoma. | Okabe M et al. | β | 2006 | β |
| Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation. | Maillard I et al. | β | 2006 | β |
| Notch signaling in stem cell systems. | Chiba S | β | 2006 | β |
| Notch signaling pathway. | Ehebauer M et al. | β | 2006 | β |
| Notch signalling: a simple pathway becomes complex. | Bray SJ | β | 2006 | β |
| Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk. | Doroquez DB et al. | β | 2006 | β |
| Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. | Nam Y et al. | β | 2006 | β |
| The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster. | Albrecht S et al. | β | 2006 | β |
| The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila. | Fuwa TJ et al. | β | 2006 | β |
| The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. | Shen H et al. | β | 2006 | β |
| XMam1, Xenopus Mastermind1, induces neural gene expression in a Notch-independent manner. | Katada T et al. | β | 2006 | β |
| Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression. | Balint K et al. | β | 2005 | β |
| Activation of the rat renin promoter by HOXD10.PBX1b.PREP1, Ets-1, and the intracellular domain of notch. | Pan L et al. | β | 2005 | β |
| A DNA transcription code for cell-specific gene activation by notch signaling. | Cave JW et al. | β | 2005 | β |
| Analyzing protein complexes in Drosophila with tandem affinity purification-mass spectrometry. | Veraksa A et al. | β | 2005 | β |
| Clear cell hidradenoma of the skin-a third tumor type with a t(11;19)--associated TORC1-MAML2 gene fusion. | Behboudi A et al. | β | 2005 | β |
| Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways. | Talora C et al. | β | 2005 | β |
| Defining 'stemness': Notch and Wnt join forces? | Jacobsen SE | β | 2005 | β |
| Deregulated NOTCH signaling in acute T-cell lymphoblastic leukemia/lymphoma: new insights, questions, and opportunities. | Aster JC | β | 2005 | β |
| Functional conservation of Notch1 and Notch2 intracellular domains. | Kraman M et al. | β | 2005 | β |
| Fusion oncogenes and tumor type specificity--insights from salivary gland tumors. | Stenman G | β | 2005 | β |
| High-resolution crystal structure of the human Notch 1 ankyrin domain. | Ehebauer MT et al. | β | 2005 | β |
| Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. | Duncan AW et al. | β | 2005 | β |
| Mammary epithelial cell transformation: insights from cell culture and mouse models. | Dimri G et al. | β | 2005 | β |
| Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. | Coxon A et al. | β | 2005 | β |
| Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling. | Barsi JC et al. | β | 2005 | β |
| Notch signaling in T-cell acute lymphoblastic leukemia. | Weng AP et al. | β | 2005 | β |
| Notch signaling in the mammalian central nervous system: insights from mouse mutants. | Yoon K et al. | β | 2005 | β |
| Notch signaling is an important regulator of type 2 immunity. | Tu L et al. | β | 2005 | β |
| Paradigms of notch signaling in mammals. | Dumortier A et al. | β | 2005 | β |
| Regulation of expression of the Epstein-Barr virus BamHI-A rightward transcripts. | Chen H et al. | β | 2005 | β |
| [Significance of molecular-cytogenetic findings in mucoepidermoid carcinoma as an example of salivary gland tumors]. | RΓΆser K et al. | β | 2005 | β |
| Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression. | Beverly LJ et al. | β | 2005 | β |
| The love-hate relationship between Ras and Notch. | Sundaram MV | β | 2005 | β |
| The Notch pathway in cancer: differentiation gone awry. | SjΓΆlund J et al. | β | 2005 | β |
| Visualization of spatiotemporal activation of Notch signaling: live monitoring and significance in neural development. | Kohyama J et al. | β | 2005 | β |
| Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. | Enlund F et al. | β | 2004 | β |
| Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors. | HΓΆflinger S et al. | β | 2004 | β |
| Anchoring notch genetics and biochemistry; structural analysis of the ankyrin domain sheds light on existing data. | Lubman OY et al. | β | 2004 | β |
| Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene. | Wu L et al. | β | 2004 | β |
| Consequences of Notch-mediated induction of Jagged1. | Ross DA et al. | β | 2004 | β |
| Differential effects of Drosophila mastermind on asymmetric cell fate specification and neuroblast formation. | Yedvobnick B et al. | β | 2004 | β |
| Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling. | Hori K et al. | β | 2004 | β |
| Dual roles for the Notch target gene Hes-1 in the differentiation of 3T3-L1 preadipocytes. | Ross DA et al. | β | 2004 | β |
| Evidence that C promoter-binding factor 1 binding is required for Notch-1-mediated repression of activator protein-1. | Chu J et al. | β | 2004 | β |
| Founder myoblasts and fibre number during adult myogenesis in Drosophila. | Dutta D et al. | β | 2004 | β |
| Identification of two binding regions for the suppressor of hairless protein within the intracellular domain of Drosophila notch. | Le Gall M et al. | β | 2004 | β |
| Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. | Maillard I et al. | β | 2004 | β |
| Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis. | Wu L et al. | β | 2004 | β |
| Multiple niches for Notch in cancer: context is everything. | Weng AP et al. | β | 2004 | β |
| Notch and Schwann cell transformation. | Li Y et al. | β | 2004 | β |
| Notch regulation of lymphocyte development and function. | Radtke F et al. | β | 2004 | β |
| Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression. | Lefort K et al. | β | 2004 | β |
| Notch signaling: the demise of elegant simplicity. | Kadesch T | β | 2004 | β |
| sel-7, a positive regulator of lin-12 activity, encodes a novel nuclear protein in Caenorhabditis elegans. | Chen J et al. | β | 2004 | β |
| Stem cells and retinal repair. | Klassen H et al. | β | 2004 | β |
| Targeting promiscuous signaling pathways in cancer: another Notch in the bedpost. | Beverly LJ et al. | β | 2004 | β |
| T-cell development made simple. | ZΓΊΓ±iga-PflΓΌcker JC | β | 2004 | β |
| The ankyrin repeat as molecular architecture for protein recognition. | Mosavi LK et al. | β | 2004 | β |
| The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration. | Six EM et al. | β | 2004 | β |
| Viral interactions with the Notch pathway. | Hayward SD | β | 2004 | β |
| Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch. | Yeh TS et al. | β | 2003 | β |
| Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation. | Dahlqvist C et al. | β | 2003 | β |
| Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. | Weng AP et al. | β | 2003 | β |
| Modulation of notch signaling during somitogenesis. | Weinmaster G et al. | β | 2003 | β |
| neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. | Sasamura T et al. | β | 2003 | β |
| Notch and cancer: best to avoid the ups and downs. | Maillard I et al. | β | 2003 | β |
| Notch and the immune system. | Maillard I et al. | β | 2003 | β |
| Notch signaling as a therapeutic target in cancer: a new approach to the development of cell fate modifying agents. | Nickoloff BJ et al. | β | 2003 | β |
| Notch signaling in lymphopoiesis. | Pear WS et al. | β | 2003 | β |
| Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis. | Beverly LJ et al. | β | 2003 | β |
| Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathways. | Espinosa L et al. | β | 2003 | β |
| Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. | Nam Y et al. | β | 2003 | β |
| t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. | Tonon G et al. | β | 2003 | β |
| The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase. | Six E et al. | β | 2003 | β |
| A functional screening assay for the isolation of transcription factors. | Wiesner C et al. | β | 2002 | β |
| A naturally occurring alternative product of the mastermind locus that represses notch signalling. | GirΓ‘ldez AJ et al. | β | 2002 | β |
| Characterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line. | Jeffries S et al. | β | 2002 | β |
| Deciphering the role of Notch signaling in lymphopoiesis. | Izon DJ et al. | β | 2002 | β |
| Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. | Izon DJ et al. | β | 2002 | β |
| HERP1 is a cell type-specific primary target of Notch. | Iso T et al. | β | 2002 | β |
| Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. | Wu L et al. | β | 2002 | β |
| Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling. | Lin SE et al. | β | 2002 | β |
| Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins. | Lai EC | β | 2002 | β |
| Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. | Fryer CJ et al. | β | 2002 | β |
| NOTCH and the patterning of ommatidial founder cells in the developing Drosophila eye. | Baker NE | β | 2002 | β |
| Notch signaling as a therapeutic target. | Nam Y et al. | β | 2002 | β |
| Notch signaling in hematopoiesis and early lymphocyte development. | Allman D et al. | β | 2002 | β |
| Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation. | Ge W et al. | β | 2002 | β |
| p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. | Wallberg AE et al. | β | 2002 | β |
| Repression of activator protein-1-mediated transcriptional activation by the Notch-1 intracellular domain. | Chu J et al. | β | 2002 | β |
| SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. | Oswald F et al. | β | 2002 | β |
| Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans. | Jarriault S et al. | β | 2002 | β |
| The notch pathway: modulation of cell fate decisions in hematopoiesis. | Ohishi K et al. | β | 2002 | β |
| XNAP, a conserved ankyrin repeat-containing protein with a role in the Notch pathway during Xenopus primary neurogenesis. | Lahaye K et al. | β | 2002 | β |
| A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters. | Kitagawa M et al. | β | 2001 | β |
| EBNA2 and Notch signalling in Epstein-Barr virus mediated immortalization of B lymphocytes. | Zimber-Strobl U et al. | β | 2001 | β |
| Identification of a novel activation domain in the Notch-responsive transcription factor CSL. | Tang Z et al. | β | 2001 | β |
| Notch receptors and hematopoiesis. | Kojika S et al. | β | 2001 | β |
| Notch signaling in leukemia. | Aster JC et al. | β | 2001 | β |
| Nrarp is a novel intracellular component of the Notch signaling pathway. | Lamar E et al. | β | 2001 | β |
| Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. | Zhou S et al. | β | 2001 | β |
| p300 acts as a transcriptional coactivator for mammalian Notch-1. | Oswald F et al. | β | 2001 | β |
| Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells. | Allman D et al. | β | 2001 | β |
| The role of protein composition in specifying nuclear inclusion formation in polyglutamine disease. | Chai Y et al. | β | 2001 | β |
| Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila. | Morel V et al. | β | 2001 | β |